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Conserved domains on  [gi|1261316951|ref|WP_097842681.1|]
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transcriptional regulator

Protein Classification

transcriptional regulator( domain architecture ID 10012759)

winged-helix type HTH-containing transcriptional regulator

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK06474 PRK06474
hypothetical protein; Provisional
 1-180 4.54e-93

hypothetical protein; Provisional


:

Pssm-ID: 235811  Cd Length: 178  Bit Score: 268.54  E-value: 4.54e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1261316951   1 MSNKVEVLMHPVRMKICQVLMRNKEdGLTPLEMVKIIENVPQATLYRHLQTMVDSGIVHVIKEKKVKSVSEKYYAINEED 80
Cdd:PRK06474    1 MSNKAEILMHPVRMKICQVLMRNKE-GLTPLELVKILKDVPQATLYRHLQTMVDSGILHVVKEKKVRSVSEKYYAINEED 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1261316951  81 AKIEGSEWKGLSNKEKLNYISYYQLSLMIQYQSYLKKLDEQNSQEDNASFSVVELKLDEEHFINFQNELNELMTKYYHVQ 160
Cdd:PRK06474   80 AKIEGSEWTGLSDDEKLNYISYYQLSLLQQYQSYLKSLEEQNSKEDKATFSVVELKLDEEEFEEFQSELNELMIKYYNSQ 159

                         170       180
                  ....*....|....*....|
gi 1261316951 161 SKGNTIEdpVRTIAITIIPE 180
Cdd:PRK06474  160 PKSDEIE--TRTVAITIIPE 177
 
Name Accession Description Interval E-value
PRK06474 PRK06474
hypothetical protein; Provisional
 1-180 4.54e-93

hypothetical protein; Provisional


Pssm-ID: 235811  Cd Length: 178  Bit Score: 268.54  E-value: 4.54e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1261316951   1 MSNKVEVLMHPVRMKICQVLMRNKEdGLTPLEMVKIIENVPQATLYRHLQTMVDSGIVHVIKEKKVKSVSEKYYAINEED 80
Cdd:PRK06474    1 MSNKAEILMHPVRMKICQVLMRNKE-GLTPLELVKILKDVPQATLYRHLQTMVDSGILHVVKEKKVRSVSEKYYAINEED 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1261316951  81 AKIEGSEWKGLSNKEKLNYISYYQLSLMIQYQSYLKKLDEQNSQEDNASFSVVELKLDEEHFINFQNELNELMTKYYHVQ 160
Cdd:PRK06474   80 AKIEGSEWTGLSDDEKLNYISYYQLSLLQQYQSYLKSLEEQNSKEDKATFSVVELKLDEEEFEEFQSELNELMIKYYNSQ 159

                         170       180
                  ....*....|....*....|
gi 1261316951 161 SKGNTIEdpVRTIAITIIPE 180
Cdd:PRK06474  160 PKSDEIE--TRTVAITIIPE 177
HTH_20 pfam12840
Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in ...
 6-65 1.08e-12

Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in transcriptional regulatory proteins.


Pssm-ID: 432824 [Multi-domain]  Cd Length: 61  Bit Score: 59.86  E-value: 1.08e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1261316951   6 EVLMHPVRMKICQVLMRnkEDGLTPLEMVKIIEnVPQATLYRHLQTMVDSGIVHVIKEKK 65
Cdd:pfam12840   5 EALADPTRLRILRALVG--DEPLTASELARRLD-ISRNTLSYHLRKLEEAGLVEVVREGR 61
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
7-82 1.71e-08

DNA-binding transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 49.50  E-value: 1.71e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1261316951   7 VLMHPVRMKICQVLMrnkEDGLTPLEMVKIIeNVPQATLYRHLQTMVDSGIVHVIKEKKvksvsEKYYAINEEDAK 82
Cdd:COG0640    16 ALADPTRLRILRLLA---EGELCVGELAEAL-GLSQSTVSHHLKVLREAGLVTSRREGR-----WVYYRLADEALA 82
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 10-80 5.66e-08

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 48.06  E-value: 5.66e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1261316951  10 HPVRMKICQVLMrnkEDGLTPLEMVKIIeNVPQATLYRHLQTMVDSGIVHVIKEKKvksvsEKYYAINEED 80
Cdd:cd00090     6 DPTRLRILRLLL---EGPLTVSELAERL-GLSQSTVSRHLKKLEEAGLVESRREGR-----RVYYSLTDAE 67
HTH_metalloreg NF033788
metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense ...
 7-82 3.79e-05

metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense toxic heavy metals such as arsenic or cadmium, and are released from DNA so that resistance factors will be expressed, include ArsR, SmtB, ZiaR, CadC, CadX, KmtR, etc. However, some members of this family, including the sporulation delaying system autorepressor SdpR and its family (see NF033789), may lack metal-binding cites and instead regulate other cellular processes.


Pssm-ID: 411368 [Multi-domain]  Cd Length: 76  Bit Score: 40.14  E-value: 3.79e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1261316951   7 VLMHPVRMKICQVLMrnkEDGLTPLEMVKIIEnVPQATLYRHLQTMVDSGIVHVIKEKKvksvsEKYYAINEEDAK 82
Cdd:NF033788    7 ALADPTRLRILELLA---EGELCVCELAEALG-LSQSAVSQHLKVLRDAGLVTSRREGR-----WVYYRLADEHVA 73
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
15-82 7.23e-05

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 39.12  E-value: 7.23e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1261316951   15 KICQVLMrnkEDGLTPLEMVKIIeNVPQATLYRHLQTMVDSGIVHVIKEKKvksvsEKYYAINEEDAK 82
Cdd:smart00418   1 KILKLLA---EGELCVCELAEIL-GLSQSTVSHHLKKLREAGLVESRREGK-----RVYYSLTDEKVA 59
 
Name Accession Description Interval E-value
PRK06474 PRK06474
hypothetical protein; Provisional
 1-180 4.54e-93

hypothetical protein; Provisional


Pssm-ID: 235811  Cd Length: 178  Bit Score: 268.54  E-value: 4.54e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1261316951   1 MSNKVEVLMHPVRMKICQVLMRNKEdGLTPLEMVKIIENVPQATLYRHLQTMVDSGIVHVIKEKKVKSVSEKYYAINEED 80
Cdd:PRK06474    1 MSNKAEILMHPVRMKICQVLMRNKE-GLTPLELVKILKDVPQATLYRHLQTMVDSGILHVVKEKKVRSVSEKYYAINEED 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1261316951  81 AKIEGSEWKGLSNKEKLNYISYYQLSLMIQYQSYLKKLDEQNSQEDNASFSVVELKLDEEHFINFQNELNELMTKYYHVQ 160
Cdd:PRK06474   80 AKIEGSEWTGLSDDEKLNYISYYQLSLLQQYQSYLKSLEEQNSKEDKATFSVVELKLDEEEFEEFQSELNELMIKYYNSQ 159

                         170       180
                  ....*....|....*....|
gi 1261316951 161 SKGNTIEdpVRTIAITIIPE 180
Cdd:PRK06474  160 PKSDEIE--TRTVAITIIPE 177
HTH_20 pfam12840
Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in ...
 6-65 1.08e-12

Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in transcriptional regulatory proteins.


Pssm-ID: 432824 [Multi-domain]  Cd Length: 61  Bit Score: 59.86  E-value: 1.08e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1261316951   6 EVLMHPVRMKICQVLMRnkEDGLTPLEMVKIIEnVPQATLYRHLQTMVDSGIVHVIKEKK 65
Cdd:pfam12840   5 EALADPTRLRILRALVG--DEPLTASELARRLD-ISRNTLSYHLRKLEEAGLVEVVREGR 61
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
7-82 1.71e-08

DNA-binding transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 49.50  E-value: 1.71e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1261316951   7 VLMHPVRMKICQVLMrnkEDGLTPLEMVKIIeNVPQATLYRHLQTMVDSGIVHVIKEKKvksvsEKYYAINEEDAK 82
Cdd:COG0640    16 ALADPTRLRILRLLA---EGELCVGELAEAL-GLSQSTVSHHLKVLREAGLVTSRREGR-----WVYYRLADEALA 82
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 10-80 5.66e-08

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 48.06  E-value: 5.66e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1261316951  10 HPVRMKICQVLMrnkEDGLTPLEMVKIIeNVPQATLYRHLQTMVDSGIVHVIKEKKvksvsEKYYAINEED 80
Cdd:cd00090     6 DPTRLRILRLLL---EGPLTVSELAERL-GLSQSTVSRHLKKLEEAGLVESRREGR-----RVYYSLTDAE 67
HTH_metalloreg NF033788
metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense ...
 7-82 3.79e-05

metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense toxic heavy metals such as arsenic or cadmium, and are released from DNA so that resistance factors will be expressed, include ArsR, SmtB, ZiaR, CadC, CadX, KmtR, etc. However, some members of this family, including the sporulation delaying system autorepressor SdpR and its family (see NF033789), may lack metal-binding cites and instead regulate other cellular processes.


Pssm-ID: 411368 [Multi-domain]  Cd Length: 76  Bit Score: 40.14  E-value: 3.79e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1261316951   7 VLMHPVRMKICQVLMrnkEDGLTPLEMVKIIEnVPQATLYRHLQTMVDSGIVHVIKEKKvksvsEKYYAINEEDAK 82
Cdd:NF033788    7 ALADPTRLRILELLA---EGELCVCELAEALG-LSQSAVSQHLKVLRDAGLVTSRREGR-----WVYYRLADEHVA 73
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
15-82 7.23e-05

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 39.12  E-value: 7.23e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1261316951   15 KICQVLMrnkEDGLTPLEMVKIIeNVPQATLYRHLQTMVDSGIVHVIKEKKvksvsEKYYAINEEDAK 82
Cdd:smart00418   1 KILKLLA---EGELCVCELAEIL-GLSQSTVSHHLKKLREAGLVESRREGK-----RVYYSLTDEKVA 59
COG1777 COG1777
Predicted transcriptional regulator, ArsR family [Transcription];
6-87 1.06e-04

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 441383  Cd Length: 113  Bit Score: 40.02  E-value: 1.06e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1261316951   6 EVLMHPVRMKICQVLmrnKEDGLTPLEMVKIIEnVPQATLYRHLQTMVDSGIVHVIKEKKVKSVSEKYYAINEEDAKIEG 85
Cdd:COG1777    12 DALGNPTRRRILALL---SEEPAYVSELARELG-VSRQAVYKHLRKLEEAGLVESYREGREDGRARKYYRLSAFRLEVTL 87


                  ..
gi 1261316951  86 SE 87
Cdd:COG1777    88 TP 89
COG4189 COG4189
Predicted transcriptional regulator, ArsR family [Transcription];
6-75 1.14e-04

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 443343 [Multi-domain]  Cd Length: 97  Bit Score: 39.56  E-value: 1.14e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1261316951   6 EVLMHPVRMKICQVLMRNkedgltPLEMVKIIE--NVPQATLYRHLQTMVDSGIVHVIKEKKVKSVSEKYYA 75
Cdd:COG4189    14 KALASETRLRILRLLAEE------PLNVNELAEalGLPKSTVSYHIRKLEEAGLIRTEYKPGKRGRQKICYL 79
COG3398 COG3398
Predicted transcriptional regulator, contains two HTH domains [Transcription];
15-80 1.03e-03

Predicted transcriptional regulator, contains two HTH domains [Transcription];


Pssm-ID: 442625 [Multi-domain]  Cd Length: 159  Bit Score: 37.94  E-value: 1.03e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1261316951  15 KICQVLMRNkeDGLTPLEMVKIIeNVPQATLYRHLQTMVDSGIVHVIKEKKvksvsEKYYAINEED 80
Cdd:COG3398   101 RILLYLLEN--PGATNKELAEEL-GISRSTVSWHLKRLEEDGLVERERDGR-----NVRYYLNPPE 158
COG3355 COG3355
Predicted transcriptional regulator [Transcription];
14-84 4.03e-03

Predicted transcriptional regulator [Transcription];


Pssm-ID: 442583 [Multi-domain]  Cd Length: 131  Bit Score: 35.71  E-value: 4.03e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1261316951  14 MKICQVLMRNKEdGLTPLEMVKIIeNVPQATLYRHLQTMVDSGIVhvikeKKVKSVSEK------YYAINEEDAKIE 84
Cdd:COG3355    30 AEVYLILLENGE-PLTVEELAEAL-DRSRSTVYRSLQKLLEAGLV-----EREKRNLEGggypyvYYAIDPEELKEK 99
Fur COG0735
Fe2+ or Zn2+ uptake regulation protein Fur/Zur [Inorganic ion transport and metabolism];
11-61 6.79e-03

Fe2+ or Zn2+ uptake regulation protein Fur/Zur [Inorganic ion transport and metabolism];


Pssm-ID: 440498  Cd Length: 140  Bit Score: 35.31  E-value: 6.79e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1261316951  11 PVRMKICQVLMrNKEDGLTP---LEMVK-IIENVPQATLYRHLQTMVDSGIVHVI 61
Cdd:COG0735    20 PQRLAILELLL-ESDRHLSAeeiYEALRkKGPSISLATVYRTLDLLVEAGLVHRI 73
FUR pfam01475
Ferric uptake regulator family; This family includes metal ion uptake regulator proteins, that ...
 11-71 9.72e-03

Ferric uptake regulator family; This family includes metal ion uptake regulator proteins, that bind to the operator DNA and controls transcription of metal ion-responsive genes. This family is also known as the FUR family.


Pssm-ID: 426280  Cd Length: 121  Bit Score: 34.53  E-value: 9.72e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1261316951  11 PVRMKICQVLMRNKEDGLTPLEMVKII----ENVPQATLYRHLQTMVDSGIVHVIKEKKVKSVSE 71
Cdd:pfam01475   8 PQRLKILEVLQKSDKEHLSAEEIYKELreedPNISLATVYRTLNLLEEAGLVKRLEFDGGESRFE 72
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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