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peptidoglycan D,D-transpeptidase FtsI family protein
Protein Classification
peptidoglycan D,D-transpeptidase FtsI family protein ( domain architecture ID 11433609 )
peptidoglycan D,D-transpeptidase FtsI (penicillin-binding protein (PBP) 2) family protein is a membrane-associated enzyme that is most likely involved in the synthesis of cross-linked peptidoglycan
List of domain hits
Name
Accession
Description
Interval
E-value
FtsI
COG0768 Cell division protein FtsI, peptidoglycan transpeptidase (Penicillin-binding protein 2) [Cell ...
39-576
2.40e-119
Cell division protein FtsI, peptidoglycan transpeptidase (Penicillin-binding protein 2) [Cell cycle control, cell division, chromosome partitioning, Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440531 [Multi-domain]
Cd Length: 568
Bit Score: 364.92
E-value: 2.40e-119
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1264319612 39 E RG K I F D Q NG VI LATN KK V K S I Y ct LND E KLSNQD tsntl AFFNQFSNEF qh DISA E DIKSQ L qqsc KK QTMNDIP L YSD 118
Cdd:COG0768 60 P RG L I Y D R NG NV LATN VP V Y S L Y -- ADP E EVKDPE ----- ETAEKLAKLL -- GLDP E ELRKK L ---- KK KSRFPVY L KRN 126
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1264319612 119 INES E LTF I NKN K PNN V IIKD E WI RYYP KH E IGSQLI GYV en DLNSKYGPV GKSG V E LQ YED D L K G K PGK TLIFKMNNKK 198
Cdd:COG0768 127 LSPE E AAR I RAL K LPG V YVEA E YK RYYP YG E LAAHVL GYV -- GEINGGDGI GKSG L E KA YED L L R G T PGK RRVEVDARGR 204
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1264319612 199 --- FSWNIQKVQR GKD VR L AL DS K LQ QKT EEAL RSQIKK t HD AK A G YA VV T D V KTG A IL T MA NSAV F N PN T lythvs F RN 275
Cdd:COG0768 205 vir DLGEEKPPVP GKD LV L TI DS D LQ KIA EEAL KKAVEE - YK AK S G AV VV M D P KTG E IL A MA SYPS F D PN L ------ F VG 277
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1264319612 276 ENIKS L s Q N K A I Q klky G E Y Y vn MA ST I KP L T ILIG L N E KLFQ P ED T YLDK G TFQYDNQN n I TNAPGTPT G EI T PRQ A II 355
Cdd:COG0768 278 GPDEP L - R N R A V Q ---- G T Y E -- PG ST F KP F T AAAA L E E GVIT P DT T FDCP G YYRVGGRT - I RDWDRGGH G TL T LTE A LA 349
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1264319612 356 N SSN TFM t A K V AL P L fnqnng N I E K vahi WT DYL MQ FGL RS KTGIDLP F E ED G QY efh PS N K FENGIS a LLNA S W G - G NE 434
Cdd:COG0768 350 K SSN VGF - Y K L AL R L ------ G I D K ---- LY DYL KK FGL GQ KTGIDLP G E AS G LL --- PS P K RWYPGE - TATM S I G q G LS 414
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1264319612 435 V h TPLQLAQ YA A TL A SK G DKY KP QI V SA I MS PDG KET K KFKPI L ES -- S NRY pmkf WSV V QG GM SQNIE E ------- IKN 505
Cdd:COG0768 415 V - TPLQLAQ AY A AI A NG G VLV KP HL V KE I VD PDG EVV K EEPEV L RR vi S PET ---- AET V RE GM EGVVN E pggtarr AAI 489
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1264319612 506 LPFH VAGKTG ---- ITGFPNEQE K MINHSL F IAY AP TED P QI A IS VV IPGSNSEKN --- I AA L V TS EI LDSWHT L QKE 576
Cdd:COG0768 490 PGYR VAGKTG taqv VDIGNGGYY K GRHIAS F VGF AP ADN P RY A VA VV VENPGGGAY ggt V AA P V FR EI MEAYLR L LGP 567
Name
Accession
Description
Interval
E-value
FtsI
COG0768 Cell division protein FtsI, peptidoglycan transpeptidase (Penicillin-binding protein 2) [Cell ...
39-576
2.40e-119
Cell division protein FtsI, peptidoglycan transpeptidase (Penicillin-binding protein 2) [Cell cycle control, cell division, chromosome partitioning, Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440531 [Multi-domain]
Cd Length: 568
Bit Score: 364.92
E-value: 2.40e-119
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1264319612 39 E RG K I F D Q NG VI LATN KK V K S I Y ct LND E KLSNQD tsntl AFFNQFSNEF qh DISA E DIKSQ L qqsc KK QTMNDIP L YSD 118
Cdd:COG0768 60 P RG L I Y D R NG NV LATN VP V Y S L Y -- ADP E EVKDPE ----- ETAEKLAKLL -- GLDP E ELRKK L ---- KK KSRFPVY L KRN 126
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1264319612 119 INES E LTF I NKN K PNN V IIKD E WI RYYP KH E IGSQLI GYV en DLNSKYGPV GKSG V E LQ YED D L K G K PGK TLIFKMNNKK 198
Cdd:COG0768 127 LSPE E AAR I RAL K LPG V YVEA E YK RYYP YG E LAAHVL GYV -- GEINGGDGI GKSG L E KA YED L L R G T PGK RRVEVDARGR 204
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1264319612 199 --- FSWNIQKVQR GKD VR L AL DS K LQ QKT EEAL RSQIKK t HD AK A G YA VV T D V KTG A IL T MA NSAV F N PN T lythvs F RN 275
Cdd:COG0768 205 vir DLGEEKPPVP GKD LV L TI DS D LQ KIA EEAL KKAVEE - YK AK S G AV VV M D P KTG E IL A MA SYPS F D PN L ------ F VG 277
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1264319612 276 ENIKS L s Q N K A I Q klky G E Y Y vn MA ST I KP L T ILIG L N E KLFQ P ED T YLDK G TFQYDNQN n I TNAPGTPT G EI T PRQ A II 355
Cdd:COG0768 278 GPDEP L - R N R A V Q ---- G T Y E -- PG ST F KP F T AAAA L E E GVIT P DT T FDCP G YYRVGGRT - I RDWDRGGH G TL T LTE A LA 349
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1264319612 356 N SSN TFM t A K V AL P L fnqnng N I E K vahi WT DYL MQ FGL RS KTGIDLP F E ED G QY efh PS N K FENGIS a LLNA S W G - G NE 434
Cdd:COG0768 350 K SSN VGF - Y K L AL R L ------ G I D K ---- LY DYL KK FGL GQ KTGIDLP G E AS G LL --- PS P K RWYPGE - TATM S I G q G LS 414
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1264319612 435 V h TPLQLAQ YA A TL A SK G DKY KP QI V SA I MS PDG KET K KFKPI L ES -- S NRY pmkf WSV V QG GM SQNIE E ------- IKN 505
Cdd:COG0768 415 V - TPLQLAQ AY A AI A NG G VLV KP HL V KE I VD PDG EVV K EEPEV L RR vi S PET ---- AET V RE GM EGVVN E pggtarr AAI 489
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1264319612 506 LPFH VAGKTG ---- ITGFPNEQE K MINHSL F IAY AP TED P QI A IS VV IPGSNSEKN --- I AA L V TS EI LDSWHT L QKE 576
Cdd:COG0768 490 PGYR VAGKTG taqv VDIGNGGYY K GRHIAS F VGF AP ADN P RY A VA VV VENPGGGAY ggt V AA P V FR EI MEAYLR L LGP 567
pbp2_mrdA
TIGR03423 penicillin-binding protein 2; Members of this protein family are penicillin-binding protein 2 ...
27-570
1.10e-83
penicillin-binding protein 2; Members of this protein family are penicillin-binding protein 2 (PBP-2), a protein whose gene (designated pbpA or mrdA) generally is found next to the gene for RodA, a protein required for rod (bacillus) shape in many bacteria. PBP-2 acts as a transpeptidase for cell elongation (hence, rod-shape). [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 274573 [Multi-domain]
Cd Length: 592
Bit Score: 272.86
E-value: 1.10e-83
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1264319612 27 N F I SITIATSS te RG K I F D Q NGV I LA T N KKVK S I yc TLND EK LSNQ D tsntl A FFNQFSNEF qh D ISA EDI KSQ L QQSCK 106
Cdd:TIGR03423 39 N R I RLVPIPPP -- RG L I L D R NGV L LA D N RPSF S L -- EIVP EK VDDL D ----- A TLDRLAKLL -- D LDP EDI ARF L KELKR 107
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1264319612 107 KQTMND IPL Y SD IN E S E LTFINK N KPN -- N V I I KDEWI RYYP KH E IGSQLI GYV ---- E N DL ---- NSK Y GP --- V GKSG 173
Cdd:TIGR03423 108 SRRFEP IPL K SD LT E E E VARFAV N QYR lp G V E I EARLK RYYP YG E LAAHVL GYV gein E E DL erle PAN Y AG gdy I GKSG 187
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1264319612 174 V E LQ YED D L K GKPG KTLI f KM N NK - KFSWNIQK V -- QR GKD VR L AL D SK LQQ KT E E AL rsqikkth DAKA G YA VV T D VK T 250
Cdd:TIGR03423 188 I E KY YED E L R GKPG YREV - EV N AR g RVIRTLSR V pp VP GKD LV L TI D AR LQQ AA E K AL -------- GGRR G AV VV M D PR T 258
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1264319612 251 G A IL T M ANSAV F N PN TLYTHV S fr NENI K S L SQ ------- N K AIQ klky G E Y yv NMA ST I KP LTI L IG L N E KLFQ PE DTY 323
Cdd:TIGR03423 259 G E IL A M VSTPS F D PN LFVDGI S -- SKDY K A L LN dpdrpll N R AIQ ---- G V Y -- PPG ST F KP VVA L AA L E E GVIT PE TRI 330
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1264319612 324 LDK G T FQ YDNQN - NITNAP G tp T G EITP R Q AI IN S SNTFMT a KV AL P L fnqnn G n I E K V A hiwt D Y LMQ FG LRS KTGIDL 402
Cdd:TIGR03423 331 YCP G Y FQ LGGRR f RCWKRG G -- H G RVDL R K AI EE S CDVYFY - QL AL R L ----- G - I D K I A ---- E Y AKR FG FGQ KTGIDL 397
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1264319612 403 P F E ED G qye FH PS ----- NK F ENG -- ISAL LN A S W G - G NEVH TPLQLA QYA A T LA SK G DK YKP QI V SA I MS PDG KETKKF 474
Cdd:TIGR03423 398 P G E KS G --- LV PS rewkr KR F GQP wy PGDT LN V S I G q G YVLV TPLQLA VAT A A LA NG G KL YKP HL V KS I ED PDG GVVRRT 474
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1264319612 475 K P ILESSNRYPMKFWS VV QG GM SQNIEE -------- IKN LP FHV AGKTG --- ITGFPNEQ -------- E KMIN H S LF I A Y 535
Cdd:TIGR03423 475 E P EVLRPLPISPENLD VV RE GM RDVVNG pggtarra RLG LP YKM AGKTG taq VVSLKQGE kydaeqip E RLRD H A LF V A F 554
570 580 590
....*....|....*....|....*....|....*
gi 1264319612 536 AP TED P Q IA IS V VIPGSNSEKNI AA LVTSE I L D SW 570
Cdd:TIGR03423 555 AP YDN P K IA VA V IVEHGGGGSSA AA PIARK I M D AY 589
Transpeptidase
pfam00905 Penicillin binding protein transpeptidase domain; The active site serine (residue 337 in Swiss: ...
241-568
1.22e-38
Penicillin binding protein transpeptidase domain; The active site serine (residue 337 in Swiss:P14677) is conserved in all members of this family.
Pssm-ID: 425939 [Multi-domain]
Cd Length: 296
Bit Score: 143.71
E-value: 1.22e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1264319612 241 G Y AVV T D V KTG AI L T M ANSAVFN PN TLYTHV sfrneniksls Q N K A IQKL kygey Y V n MA ST I KP L T I L IG L NEKLFQ P E 320
Cdd:pfam00905 1 G S AVV L D P KTG EV L A M VGKPSYD PN GFIGPL ----------- R N R A VTSR ----- Y E - PG ST F KP F T A L AA L DNGVLK P D 63
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1264319612 321 D T YL D KGTF Q YDNQ n N I TNAPGTPT G EI T P RQA IIN SSN TF M t A K V A LP L fnqnng NIE K vahi WTD YL MQ FG LRS KTGI 400
Cdd:pfam00905 64 E T IF D WPGK Q QGGK - S I GDWNQDQV G IG T L RQA LEY SSN WY M - Q K L A QK L ------ GAD K ---- LRS YL KK FG YGN KTGI 131
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1264319612 401 D LP F E ED G Q yefhpsn KFENGISALLNASWG G NEV h TPLQ L AQ YA A TL A SK G DKYK P QI V SA I MSPDGKETKKFK PI LE S 480
Cdd:pfam00905 132 G LP G E NA G Y ------- LTPYWLEGATASFGI G LTI - TPLQ Q AQ AY A AI A NG G KLVP P HL V KS I EDKVDPKVLNKL PI SK S 203
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1264319612 481 SN --- RYPMK fw S VV QG G MSQNIEEI kn LPFH VAGKTG ---- ITGFPNEQEKMINHSL F IA YAP TED P QI A IS V V I -- P G 551
Cdd:pfam00905 204 TA ekv KDMLR -- L VV ND G TGTGTAAV -- PGYK VAGKTG taqv AGPKGGGYYDGAQIGW F VG YAP ADN P KY A FA V L I dd P K 279
330
....*....|....*..
gi 1264319612 552 SNSEKNI AA LVTSE IL D 568
Cdd:pfam00905 280 RYYGGKV AA PIFKD IL E 296
PRK10795
PRK10795 penicillin-binding protein 2; Provisional
31-579
2.61e-28
penicillin-binding protein 2; Provisional
Pssm-ID: 236761 [Multi-domain]
Cd Length: 634
Bit Score: 119.87
E-value: 2.61e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1264319612 31 IT IA T S ste RG K I F D Q NG VI LA T N K kvk S IY - CTLND EK LS N - Q D T SNT L AFFN qfsnefqh D ISAE DI KSQLQQSCKKQ 108
Cdd:PRK10795 63 VP IA P S --- RG I I Y D R NG TP LA L N R --- T IY q LEMMP EK VD N l Q Q T LDA L RSVV -------- D LTDD DI AAFRKERARSR 128
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1264319612 109 TMND IP LYSDIN E SELT -- FI N KNKPNN V II K DEWI RYYP KHEIGSQL IGYV E -- ND LN ---------- SK Y GP --- V GK 171
Cdd:PRK10795 129 RFTS IP VKTNLT E VQVA rf AV N QYRFPG V EV K GYQR RYYP YGSALTHV IGYV S ki ND KD verldkegkl AN Y AA thd I GK 208
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1264319612 172 S G V E LQ YED D L K GK P G KTLI f KM NN KKF --- SWNI Q KV Q R G K D VR L A LD S KLQQ KT E EA L RS qikkthd AK A G y A VVTD V 248
Cdd:PRK10795 209 L G I E RY YED V L H GK T G YEEV - EV NN RGR vir QLHE Q PP Q A G H D IY L T LD L KLQQ YI E TL L AG ------- SR A A - V VVTD P 279
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1264319612 249 K TG A IL TMANSAVFN PN TLYTHV S fr NENIKS L SQ ------- N K A I Q klky G E Y yv NM AST I KP LTILIG L NEKLFQPED 321
Cdd:PRK10795 280 R TG G IL ALVSTPSYD PN LFVDGI S -- SKDYSG L LN dpnrpli N R A T Q ---- G V Y -- PP AST V KP YVAVSA L SAGVITRNT 351
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1264319612 322 TYL D K G TF Q Y dnqnnitna PG TPT ---------- G EITPRQAIIN S SN TF MT a K VA LPL fnqnng N I EKVA hiwt DYLMQ 391
Cdd:PRK10795 352 SLF D P G WW Q L --------- PG SEK ryrdwkkwgh G RLNVTKSLEE S AD TF FY - Q VA YDM ------ G I DRLS ---- EWMGK 411
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1264319612 392 FG LRSK TGIDL PF E ED G -------- Q YE F H ---- PSNKFEN GI SA llnaswg G NEVH TP L Q LAQYAA TL ASK G DKYK P QI 459
Cdd:PRK10795 412 FG YGHY TGIDL AE E RS G nmptrewk Q KR F K kpwy QGDTIPV GI GQ ------- G YWTA TP I Q MSKALM TL IND G IVKV P HL 484
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1264319612 460 VSAIMS p DGK ETKKFK P ILESSNRYPMKF W SVVQG GM -------- SQNIEEIKNL P FHV A G K T G --- IT G F - P NE Q ---- 523
Cdd:PRK10795 485 LMSTAE - DGK QVPWVQ P HEPPVGDIHSGY W EIAKD GM ygvanrpn GTAHKYFASA P YKI A A K S G taq VF G L k A NE T ynah 563
570 580 590 600 610
....*....|....*....|....*....|....*....|....*....|....*....
gi 1264319612 524 --- E KMIN H S L FI A Y AP TED PQ I A ISVVIPGSNSEKNIAA l VTSE ILD sw H TLQKE NN S 579
Cdd:PRK10795 564 kia E RLRD H K L MT A F AP YNN PQ V A VAIILENGGAGPAVGT - IMRQ ILD -- H IMLGD NN T 619
Name
Accession
Description
Interval
E-value
FtsI
COG0768 Cell division protein FtsI, peptidoglycan transpeptidase (Penicillin-binding protein 2) [Cell ...
39-576
2.40e-119
Cell division protein FtsI, peptidoglycan transpeptidase (Penicillin-binding protein 2) [Cell cycle control, cell division, chromosome partitioning, Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440531 [Multi-domain]
Cd Length: 568
Bit Score: 364.92
E-value: 2.40e-119
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1264319612 39 E RG K I F D Q NG VI LATN KK V K S I Y ct LND E KLSNQD tsntl AFFNQFSNEF qh DISA E DIKSQ L qqsc KK QTMNDIP L YSD 118
Cdd:COG0768 60 P RG L I Y D R NG NV LATN VP V Y S L Y -- ADP E EVKDPE ----- ETAEKLAKLL -- GLDP E ELRKK L ---- KK KSRFPVY L KRN 126
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1264319612 119 INES E LTF I NKN K PNN V IIKD E WI RYYP KH E IGSQLI GYV en DLNSKYGPV GKSG V E LQ YED D L K G K PGK TLIFKMNNKK 198
Cdd:COG0768 127 LSPE E AAR I RAL K LPG V YVEA E YK RYYP YG E LAAHVL GYV -- GEINGGDGI GKSG L E KA YED L L R G T PGK RRVEVDARGR 204
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1264319612 199 --- FSWNIQKVQR GKD VR L AL DS K LQ QKT EEAL RSQIKK t HD AK A G YA VV T D V KTG A IL T MA NSAV F N PN T lythvs F RN 275
Cdd:COG0768 205 vir DLGEEKPPVP GKD LV L TI DS D LQ KIA EEAL KKAVEE - YK AK S G AV VV M D P KTG E IL A MA SYPS F D PN L ------ F VG 277
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1264319612 276 ENIKS L s Q N K A I Q klky G E Y Y vn MA ST I KP L T ILIG L N E KLFQ P ED T YLDK G TFQYDNQN n I TNAPGTPT G EI T PRQ A II 355
Cdd:COG0768 278 GPDEP L - R N R A V Q ---- G T Y E -- PG ST F KP F T AAAA L E E GVIT P DT T FDCP G YYRVGGRT - I RDWDRGGH G TL T LTE A LA 349
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1264319612 356 N SSN TFM t A K V AL P L fnqnng N I E K vahi WT DYL MQ FGL RS KTGIDLP F E ED G QY efh PS N K FENGIS a LLNA S W G - G NE 434
Cdd:COG0768 350 K SSN VGF - Y K L AL R L ------ G I D K ---- LY DYL KK FGL GQ KTGIDLP G E AS G LL --- PS P K RWYPGE - TATM S I G q G LS 414
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1264319612 435 V h TPLQLAQ YA A TL A SK G DKY KP QI V SA I MS PDG KET K KFKPI L ES -- S NRY pmkf WSV V QG GM SQNIE E ------- IKN 505
Cdd:COG0768 415 V - TPLQLAQ AY A AI A NG G VLV KP HL V KE I VD PDG EVV K EEPEV L RR vi S PET ---- AET V RE GM EGVVN E pggtarr AAI 489
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1264319612 506 LPFH VAGKTG ---- ITGFPNEQE K MINHSL F IAY AP TED P QI A IS VV IPGSNSEKN --- I AA L V TS EI LDSWHT L QKE 576
Cdd:COG0768 490 PGYR VAGKTG taqv VDIGNGGYY K GRHIAS F VGF AP ADN P RY A VA VV VENPGGGAY ggt V AA P V FR EI MEAYLR L LGP 567
pbp2_mrdA
TIGR03423 penicillin-binding protein 2; Members of this protein family are penicillin-binding protein 2 ...
27-570
1.10e-83
penicillin-binding protein 2; Members of this protein family are penicillin-binding protein 2 (PBP-2), a protein whose gene (designated pbpA or mrdA) generally is found next to the gene for RodA, a protein required for rod (bacillus) shape in many bacteria. PBP-2 acts as a transpeptidase for cell elongation (hence, rod-shape). [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 274573 [Multi-domain]
Cd Length: 592
Bit Score: 272.86
E-value: 1.10e-83
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1264319612 27 N F I SITIATSS te RG K I F D Q NGV I LA T N KKVK S I yc TLND EK LSNQ D tsntl A FFNQFSNEF qh D ISA EDI KSQ L QQSCK 106
Cdd:TIGR03423 39 N R I RLVPIPPP -- RG L I L D R NGV L LA D N RPSF S L -- EIVP EK VDDL D ----- A TLDRLAKLL -- D LDP EDI ARF L KELKR 107
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1264319612 107 KQTMND IPL Y SD IN E S E LTFINK N KPN -- N V I I KDEWI RYYP KH E IGSQLI GYV ---- E N DL ---- NSK Y GP --- V GKSG 173
Cdd:TIGR03423 108 SRRFEP IPL K SD LT E E E VARFAV N QYR lp G V E I EARLK RYYP YG E LAAHVL GYV gein E E DL erle PAN Y AG gdy I GKSG 187
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1264319612 174 V E LQ YED D L K GKPG KTLI f KM N NK - KFSWNIQK V -- QR GKD VR L AL D SK LQQ KT E E AL rsqikkth DAKA G YA VV T D VK T 250
Cdd:TIGR03423 188 I E KY YED E L R GKPG YREV - EV N AR g RVIRTLSR V pp VP GKD LV L TI D AR LQQ AA E K AL -------- GGRR G AV VV M D PR T 258
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1264319612 251 G A IL T M ANSAV F N PN TLYTHV S fr NENI K S L SQ ------- N K AIQ klky G E Y yv NMA ST I KP LTI L IG L N E KLFQ PE DTY 323
Cdd:TIGR03423 259 G E IL A M VSTPS F D PN LFVDGI S -- SKDY K A L LN dpdrpll N R AIQ ---- G V Y -- PPG ST F KP VVA L AA L E E GVIT PE TRI 330
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1264319612 324 LDK G T FQ YDNQN - NITNAP G tp T G EITP R Q AI IN S SNTFMT a KV AL P L fnqnn G n I E K V A hiwt D Y LMQ FG LRS KTGIDL 402
Cdd:TIGR03423 331 YCP G Y FQ LGGRR f RCWKRG G -- H G RVDL R K AI EE S CDVYFY - QL AL R L ----- G - I D K I A ---- E Y AKR FG FGQ KTGIDL 397
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1264319612 403 P F E ED G qye FH PS ----- NK F ENG -- ISAL LN A S W G - G NEVH TPLQLA QYA A T LA SK G DK YKP QI V SA I MS PDG KETKKF 474
Cdd:TIGR03423 398 P G E KS G --- LV PS rewkr KR F GQP wy PGDT LN V S I G q G YVLV TPLQLA VAT A A LA NG G KL YKP HL V KS I ED PDG GVVRRT 474
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1264319612 475 K P ILESSNRYPMKFWS VV QG GM SQNIEE -------- IKN LP FHV AGKTG --- ITGFPNEQ -------- E KMIN H S LF I A Y 535
Cdd:TIGR03423 475 E P EVLRPLPISPENLD VV RE GM RDVVNG pggtarra RLG LP YKM AGKTG taq VVSLKQGE kydaeqip E RLRD H A LF V A F 554
570 580 590
....*....|....*....|....*....|....*
gi 1264319612 536 AP TED P Q IA IS V VIPGSNSEKNI AA LVTSE I L D SW 570
Cdd:TIGR03423 555 AP YDN P K IA VA V IVEHGGGGSSA AA PIARK I M D AY 589
Transpeptidase
pfam00905 Penicillin binding protein transpeptidase domain; The active site serine (residue 337 in Swiss: ...
241-568
1.22e-38
Penicillin binding protein transpeptidase domain; The active site serine (residue 337 in Swiss:P14677) is conserved in all members of this family.
Pssm-ID: 425939 [Multi-domain]
Cd Length: 296
Bit Score: 143.71
E-value: 1.22e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1264319612 241 G Y AVV T D V KTG AI L T M ANSAVFN PN TLYTHV sfrneniksls Q N K A IQKL kygey Y V n MA ST I KP L T I L IG L NEKLFQ P E 320
Cdd:pfam00905 1 G S AVV L D P KTG EV L A M VGKPSYD PN GFIGPL ----------- R N R A VTSR ----- Y E - PG ST F KP F T A L AA L DNGVLK P D 63
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1264319612 321 D T YL D KGTF Q YDNQ n N I TNAPGTPT G EI T P RQA IIN SSN TF M t A K V A LP L fnqnng NIE K vahi WTD YL MQ FG LRS KTGI 400
Cdd:pfam00905 64 E T IF D WPGK Q QGGK - S I GDWNQDQV G IG T L RQA LEY SSN WY M - Q K L A QK L ------ GAD K ---- LRS YL KK FG YGN KTGI 131
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1264319612 401 D LP F E ED G Q yefhpsn KFENGISALLNASWG G NEV h TPLQ L AQ YA A TL A SK G DKYK P QI V SA I MSPDGKETKKFK PI LE S 480
Cdd:pfam00905 132 G LP G E NA G Y ------- LTPYWLEGATASFGI G LTI - TPLQ Q AQ AY A AI A NG G KLVP P HL V KS I EDKVDPKVLNKL PI SK S 203
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1264319612 481 SN --- RYPMK fw S VV QG G MSQNIEEI kn LPFH VAGKTG ---- ITGFPNEQEKMINHSL F IA YAP TED P QI A IS V V I -- P G 551
Cdd:pfam00905 204 TA ekv KDMLR -- L VV ND G TGTGTAAV -- PGYK VAGKTG taqv AGPKGGGYYDGAQIGW F VG YAP ADN P KY A FA V L I dd P K 279
330
....*....|....*..
gi 1264319612 552 SNSEKNI AA LVTSE IL D 568
Cdd:pfam00905 280 RYYGGKV AA PIFKD IL E 296
PBP_dimer
pfam03717 Penicillin-binding Protein dimerization domain; This domain is found at the N terminus of ...
39-191
9.28e-36
Penicillin-binding Protein dimerization domain; This domain is found at the N terminus of Class B High Molecular Weight Penicillin-Binding Proteins. Its function has not been precisely defined, but is strongly implicated in PBP polymerization. The domain forms a largely disordered 'sugar tongs' structure.
Pssm-ID: 427460 [Multi-domain]
Cd Length: 178
Bit Score: 132.06
E-value: 9.28e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1264319612 39 E RG K I F D Q NGV I LATNK K V K S I yc T LNDE KL SNQ D TSN T LAFFNQFSN e FQH D ISA ED IKSQLQQSCKKQTMNDIPLYSD 118
Cdd:pfam03717 5 P RG E I Y D R NGV V LATNK P V Y S L -- T ITPS KL KKA D ALK T ALKLAKLLS - NYE D LDD ED LTERFLKMNSYKSYYPVVIKKN 81
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1264319612 119 IN E S E LTF I NK N KPN -- N V I I KDEWI RYYP KH E IGSQ L I GYV -------- E ND L NSK Y GP --- VGKSG V E L QYE DD L K GK 185
Cdd:pfam03717 82 LS E E E VAR I EE N LLE lp G V S I ETDPV RYYP YG E LAAH L L GYV geiteeel E KY L DKG Y SR gdl VGKSG L E K QYE SV L R GK 161
....*.
gi 1264319612 186 P G KTLI 191
Cdd:pfam03717 162 D G VRQV 167
PRK10795
PRK10795 penicillin-binding protein 2; Provisional
31-579
2.61e-28
penicillin-binding protein 2; Provisional
Pssm-ID: 236761 [Multi-domain]
Cd Length: 634
Bit Score: 119.87
E-value: 2.61e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1264319612 31 IT IA T S ste RG K I F D Q NG VI LA T N K kvk S IY - CTLND EK LS N - Q D T SNT L AFFN qfsnefqh D ISAE DI KSQLQQSCKKQ 108
Cdd:PRK10795 63 VP IA P S --- RG I I Y D R NG TP LA L N R --- T IY q LEMMP EK VD N l Q Q T LDA L RSVV -------- D LTDD DI AAFRKERARSR 128
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1264319612 109 TMND IP LYSDIN E SELT -- FI N KNKPNN V II K DEWI RYYP KHEIGSQL IGYV E -- ND LN ---------- SK Y GP --- V GK 171
Cdd:PRK10795 129 RFTS IP VKTNLT E VQVA rf AV N QYRFPG V EV K GYQR RYYP YGSALTHV IGYV S ki ND KD verldkegkl AN Y AA thd I GK 208
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1264319612 172 S G V E LQ YED D L K GK P G KTLI f KM NN KKF --- SWNI Q KV Q R G K D VR L A LD S KLQQ KT E EA L RS qikkthd AK A G y A VVTD V 248
Cdd:PRK10795 209 L G I E RY YED V L H GK T G YEEV - EV NN RGR vir QLHE Q PP Q A G H D IY L T LD L KLQQ YI E TL L AG ------- SR A A - V VVTD P 279
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1264319612 249 K TG A IL TMANSAVFN PN TLYTHV S fr NENIKS L SQ ------- N K A I Q klky G E Y yv NM AST I KP LTILIG L NEKLFQPED 321
Cdd:PRK10795 280 R TG G IL ALVSTPSYD PN LFVDGI S -- SKDYSG L LN dpnrpli N R A T Q ---- G V Y -- PP AST V KP YVAVSA L SAGVITRNT 351
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1264319612 322 TYL D K G TF Q Y dnqnnitna PG TPT ---------- G EITPRQAIIN S SN TF MT a K VA LPL fnqnng N I EKVA hiwt DYLMQ 391
Cdd:PRK10795 352 SLF D P G WW Q L --------- PG SEK ryrdwkkwgh G RLNVTKSLEE S AD TF FY - Q VA YDM ------ G I DRLS ---- EWMGK 411
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1264319612 392 FG LRSK TGIDL PF E ED G -------- Q YE F H ---- PSNKFEN GI SA llnaswg G NEVH TP L Q LAQYAA TL ASK G DKYK P QI 459
Cdd:PRK10795 412 FG YGHY TGIDL AE E RS G nmptrewk Q KR F K kpwy QGDTIPV GI GQ ------- G YWTA TP I Q MSKALM TL IND G IVKV P HL 484
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1264319612 460 VSAIMS p DGK ETKKFK P ILESSNRYPMKF W SVVQG GM -------- SQNIEEIKNL P FHV A G K T G --- IT G F - P NE Q ---- 523
Cdd:PRK10795 485 LMSTAE - DGK QVPWVQ P HEPPVGDIHSGY W EIAKD GM ygvanrpn GTAHKYFASA P YKI A A K S G taq VF G L k A NE T ynah 563
570 580 590 600 610
....*....|....*....|....*....|....*....|....*....|....*....
gi 1264319612 524 --- E KMIN H S L FI A Y AP TED PQ I A ISVVIPGSNSEKNIAA l VTSE ILD sw H TLQKE NN S 579
Cdd:PRK10795 564 kia E RLRD H K L MT A F AP YNN PQ V A VAIILENGGAGPAVGT - IMRQ ILD -- H IMLGD NN T 619
MrcB
COG0744 Penicillin-binding protein 1B/1F, peptidoglycan transglycosylase/transpeptidase [Cell wall ...
207-547
5.30e-23
Penicillin-binding protein 1B/1F, peptidoglycan transglycosylase/transpeptidase [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440507 [Multi-domain]
Cd Length: 630
Bit Score: 103.46
E-value: 5.30e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1264319612 207 QR G KDVRLA LD S KLQ QKT E E A LRSQI - KKTHDAKAGYA VV T D V KTG AI L T M A nsavfnpntlythvsfrneniksls QNK 285
Cdd:COG0744 292 RG G LKIYTT LD P KLQ KAA E K A VKNVL p EGKPGGLQAAL VV V D P KTG EV L A M V ------------------------- GGR 346
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1264319612 286 aiqkl K YG EYYV N M A -------- ST I KP LTILIG L NEK l FQ P ED T YL D KGTFQYDNQNNIT N AP G TPT G EI T P R Q A II NS 357
Cdd:COG0744 347 ----- D YG KSQF N R A tqakrqpg ST F KP FVYAAA L EQG - YT P AT T VD D EPVTFPGGGWSPK N YD G RYR G PV T L R E A LA NS 420
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1264319612 358 S NT fmtak V A LP L FNQNN gn IE KV A hiwt D YLMQF G LR S K tgidlpfeedgqyefhpsnk FENGI S AL L nasw G GN EV h T 437
Cdd:COG0744 421 L NT ----- P A VR L AQEVG -- LD KV V ---- D TARRL G IT S P -------------------- LDPNP S LA L ---- G TS EV - S 464
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1264319612 438 PL QL A QYA AT L A SK G DKYK P QIVSAIMSP DGK ETKKF KP IL E --- S SN ----- RYPMK fw S VV QG G MSQNI e EIKNL P fh 509
Cdd:COG0744 465 PL EM A SAY AT F A NG G VYVE P HAITKVTDA DGK VLYEA KP KC E qvi S PE vaylm TDMLQ -- D VV TS G TGRAA - RLPGR P -- 539
330 340 350
....*....|....*....|....*....|....*...
gi 1264319612 510 VAGKTG I T gfpn EQEK min HSL F IA Y apte D PQ IAIS V 547
Cdd:COG0744 540 VAGKTG T T ---- NDNR --- DAW F VG Y ---- T PQ LVTA V 566
PRK15105
PRK15105 peptidoglycan synthase FtsI; Provisional
30-549
6.28e-23
peptidoglycan synthase FtsI; Provisional
Pssm-ID: 185060 [Multi-domain]
Cd Length: 578
Bit Score: 102.98
E-value: 6.28e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1264319612 30 S ITIATS ST E RG K I F D QN G VI LA TNKK VK S I YC tln D E K LSNQDTSNTL affnqfsn EFQHDIS A EDIKSQ L Q Q SCKKQT 109
Cdd:PRK15105 60 S LRVQEV ST S RG M I T D RS G RP LA VSVP VK A I WA --- D P K EVHDAGGISV -------- DDRWKAL A DALNIP L D Q LSARIN 128
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1264319612 110 M N D ---- I P L YSDI N ESELTF I N K N K PNNVIIKD E WI RYYP KH E IGSQ LIG YVEN D LN skygpv G KS GVE LQYEDD L K G K 185
Cdd:PRK15105 129 A N P kgrf I Y L ARQV N PDMADY I K K L K LPGIHLRE E SR RYYP SG E VTAH LIG FTNV D SQ ------ G IE GVE KSFDKW L T G Q 202
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1264319612 186 PG KTLIF K MNNKKFSWN I QKV -- Q RGKDVR L AL D SK LQ QKTEEA L RSQIK k THD A KA G Y AV VT DV K TG AI L T MANS AVF N 263
Cdd:PRK15105 203 PG ERIVR K DRYGRVIED I SST ds Q AAHNLA L SI D ER LQ ALVYRE L NNAVA - FNK A ES G S AV LV DV N TG EV L A MANS PSY N 281
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1264319612 264 PN T L ythvsfr NENI K SLSQ N K AI QKL kygeyy VNMA ST I KP LTILIG L NEKLFQ p E DTY L DKGTF q YD N QNN I TNAPGT 343
Cdd:PRK15105 282 PN N L ------- SGTP K DAMR N R AI TDV ------ FEPG ST V KP MVVMTA L QRGVVK - E NSV L NTVPY - RI N GHE I KDVARY 346
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1264319612 344 PTGEI T prq AIINS S NTFMTA K V AL PL fnqnngniek VAHIWT D YLMQ FGL RSK T GID L PF E ED G Q Y efh P SNKFENG I S 423
Cdd:PRK15105 347 SELTL T --- GVLQK S SNVGVS K L AL AM ---------- PSSALV D TYSR FGL GKA T NLG L VG E RS G L Y --- P QKQRWSD I E 410
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1264319612 424 A l LNA S W G GNEVH TPLQLA QYA AT LA S K G d K Y K P QIVSAIMS P DGK E t KK F KPILESSNRYP M KFWSVVQ GG MSQ ni EE I 503
Cdd:PRK15105 411 R - ATF S F G YGLMV TPLQLA RVY AT IG S Y G - I Y R P LSITKVDP P VPG E - RV F PESIVRTVVHM M ESVALPG GG GVK -- AA I 485
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|
gi 1264319612 504 K N lp FHV A G KTG ITGFPNEQEKM IN H sl F IAY ---- AP TED P QI A IS VVI 549
Cdd:PRK15105 486 K G -- YRI A I KTG TAKKVGPDGRY IN K -- Y IAY tagv AP ASQ P RF A LV VVI 531
Blast search parameters
Data Source:
Precalculated data, version = cdd.v.3.21
Preset Options: Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
