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Conserved domains on  [gi|1264340914|ref|WP_097955032.1|]
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DUF3991 and TOPRIM domain-containing protein

Protein Classification

DUF3991 and TOPRIM domain-containing protein( domain architecture ID 10586973)

DUF3991 and toprim (topoisomerase-primase) domain-containing protein may function as a bifunctional DNA primase/helicase

Gene Ontology:  GO:0006260|GO:0003677

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DUF3991 pfam13154
Protein of unknown function (DUF3991); This family of proteins is often associated with family ...
 122-193 3.84e-10

Protein of unknown function (DUF3991); This family of proteins is often associated with family Toprim, pfam01751.


:

Pssm-ID: 432999  Cd Length: 74  Bit Score: 55.36  E-value: 3.84e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1264340914 122 YLIDERKIDPRLVNWLIKKDLIAQDKKNNVVFKWREEggKGQVIGMNRQGTVKmenkrGSFKQIVPNYEKIN 193
Cdd:pfam13154   2 YLTKQRGIPPEIVRAFIRQDLLYEDPYGNAVFVHYDE--NGKVTGAEERGTYG-----KSFKGFVSGGSKVL 66
Toprim_2 super family cl48160
Toprim-like; This is a family or Toprim-like proteins.
 210-296 4.54e-07

Toprim-like; This is a family or Toprim-like proteins.


The actual alignment was detected with superfamily member pfam13155:

Pssm-ID: 463793 [Multi-domain]  Cd Length: 88  Bit Score: 47.17  E-value: 4.54e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1264340914 210 EDPIDMLSHWsikQNKIQNARLVSMHGLK-SKTVIQSLMDAKKEghdikeVIMAVDNDKAGKDFIQTMR-----CFVDLK 283
Cdd:pfam13155   4 EGYIDALSLA---QAGIKNVLYVATLGTAlTEAQIKLLKRYPKE------VILAFDNDEAGRKAAKRLAellkeAGVDVK 74

                          90
                  ....*....|...
gi 1264340914 284 EDIPMNEKDWNDV 296
Cdd:pfam13155  75 IRLLPDGKDWNEY 87
 
Name Accession Description Interval E-value
DUF3991 pfam13154
Protein of unknown function (DUF3991); This family of proteins is often associated with family ...
 122-193 3.84e-10

Protein of unknown function (DUF3991); This family of proteins is often associated with family Toprim, pfam01751.


Pssm-ID: 432999  Cd Length: 74  Bit Score: 55.36  E-value: 3.84e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1264340914 122 YLIDERKIDPRLVNWLIKKDLIAQDKKNNVVFKWREEggKGQVIGMNRQGTVKmenkrGSFKQIVPNYEKIN 193
Cdd:pfam13154   2 YLTKQRGIPPEIVRAFIRQDLLYEDPYGNAVFVHYDE--NGKVTGAEERGTYG-----KSFKGFVSGGSKVL 66
Toprim_2 pfam13155
Toprim-like; This is a family or Toprim-like proteins.
 210-296 4.54e-07

Toprim-like; This is a family or Toprim-like proteins.


Pssm-ID: 463793 [Multi-domain]  Cd Length: 88  Bit Score: 47.17  E-value: 4.54e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1264340914 210 EDPIDMLSHWsikQNKIQNARLVSMHGLK-SKTVIQSLMDAKKEghdikeVIMAVDNDKAGKDFIQTMR-----CFVDLK 283
Cdd:pfam13155   4 EGYIDALSLA---QAGIKNVLYVATLGTAlTEAQIKLLKRYPKE------VILAFDNDEAGRKAAKRLAellkeAGVDVK 74

                          90
                  ....*....|...
gi 1264340914 284 EDIPMNEKDWNDV 296
Cdd:pfam13155  75 IRLLPDGKDWNEY 87
 
Name Accession Description Interval E-value
DUF3991 pfam13154
Protein of unknown function (DUF3991); This family of proteins is often associated with family ...
 122-193 3.84e-10

Protein of unknown function (DUF3991); This family of proteins is often associated with family Toprim, pfam01751.


Pssm-ID: 432999  Cd Length: 74  Bit Score: 55.36  E-value: 3.84e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1264340914 122 YLIDERKIDPRLVNWLIKKDLIAQDKKNNVVFKWREEggKGQVIGMNRQGTVKmenkrGSFKQIVPNYEKIN 193
Cdd:pfam13154   2 YLTKQRGIPPEIVRAFIRQDLLYEDPYGNAVFVHYDE--NGKVTGAEERGTYG-----KSFKGFVSGGSKVL 66
Toprim_2 pfam13155
Toprim-like; This is a family or Toprim-like proteins.
 210-296 4.54e-07

Toprim-like; This is a family or Toprim-like proteins.


Pssm-ID: 463793 [Multi-domain]  Cd Length: 88  Bit Score: 47.17  E-value: 4.54e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1264340914 210 EDPIDMLSHWsikQNKIQNARLVSMHGLK-SKTVIQSLMDAKKEghdikeVIMAVDNDKAGKDFIQTMR-----CFVDLK 283
Cdd:pfam13155   4 EGYIDALSLA---QAGIKNVLYVATLGTAlTEAQIKLLKRYPKE------VILAFDNDEAGRKAAKRLAellkeAGVDVK 74

                          90
                  ....*....|...
gi 1264340914 284 EDIPMNEKDWNDV 296
Cdd:pfam13155  75 IRLLPDGKDWNEY 87
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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