|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
15-391 |
3.68e-72 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 230.96 E-value: 3.68e-72
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 15 IIIGTLFARFATSMSIPFLAIYLTTVKGVSAGMTGAIIGTSALVGVFASFIGGNLSDRFGRNMIIIWSMIAWVFVFIGFS 94
Cdd:cd17329 4 LLIGSFLNRLGFFMVWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLG 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 95 FANHVLSFFLLNALNGLCRSFFEPTSRALLSDLTKPEYRLLVYNLRYGAINVGVAIGPLVGLQIGSAKSTIPFLVAAGVY 174
Cdd:cd17329 84 FAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLYSFRLLFLAAAVLF 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 175 ILYTAILAFQFkkyPIEKKKVNTEKPVTMLNAVRILRKDVVFLVALVGIILSNCGFSHLTTTVSQYFANAHIFqdGVTLF 254
Cdd:cd17329 164 LLAALVLLFLL---PETRPKRRAAEKTEILRGYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGL--GESLL 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 255 SYMLALNAIVVVVIQYPVIQICKKYTPLTSIMVGTLFVSGGLFGFGIVESTLGAAVCTIIFTIGEVLMFSMTDVFIDDIA 334
Cdd:cd17329 239 GLLLALNALLIVLLQFPVARLVERFRLRKILMIGILLFAIGFAVLAFANTLAVLILAMIVLTLGEMLVFPAVQTLVAALA 318
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 1267255154 335 VSHLKGTYFG-AMGFSGIGAVIGPWFGGVLLDYYGYQNGFVVFSALAIFSTVAFPVLV 391
Cdd:cd17329 319 PPDKRGSYMGfYALAWGLGRAIGPLVGGLLLDLLGPGLPWLILAALGLIAAALLLGLQ 376
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
15-387 |
4.90e-37 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 138.48 E-value: 4.90e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 15 IIIGTLFARFATSMSIPFLAIYLTTVkGVSAGMTGAIIGTSALVGVFASFIGGNLSDRFGRNMIIIWSMIAWVFVFIGFS 94
Cdd:cd17325 1 LSLALFLDMLGYGIIIPILPLYAESL-GASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 95 FANHVLSFFLLNALNGLCRSFFEPTSRALLSDLTKPEYRLLVYNLRYGAINVGVAIGPLVGLQIGSAKS-TIPFLVAAGV 173
Cdd:cd17325 80 FATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGyRAPFLVCAAL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 174 YILyTAILAFQFKKYPIEKKKVNTEKPVTMLNAVRILRKDVVFLVALVGIILSNCGFSHLTTTVSQYFanAHIFQDGVTL 253
Cdd:cd17325 160 ALL-ALVLALLLLPEPRPPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYA--AELGGLSPAQ 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 254 FSYMLALNAIVVVVIQYPVIQICKKYTPLTSIMVGTLFVSGGLFGFGIVESTLGAAVCTIIFTIGEVLMFSMTDVFIDDI 333
Cdd:cd17325 237 IGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADI 316
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 1267255154 334 AVSHLKGTYFGAMG-FSGIGAVIGPWFGGVLLDYYGYQNGFVVFSALAIFSTVAF 387
Cdd:cd17325 317 VPPEGRGTAMGLFNtAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLF 371
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
17-372 |
2.66e-30 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 121.16 E-value: 2.66e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 17 IGTLFARFATSMSIPFLAIYLTTVKGVSAGMTGAIIGTSALVGVFASFIGGNLSD----RFGRNM-IIIWSMIAWVFVFI 91
Cdd:COG2211 17 LGDLGLNLAFGLLSAYLLYFYTDVLGLSAALVGLILLVARLWDAITDPLIGALSDrtrtRWGRRRpWILIGAIPLALSFV 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 92 ------GFSFANHVLSFFLLNALNGLCRSFFEPTSRALLSDLTK-PEYRLLVYNLRYGAINVGVAIGPLVGLQIGSAKS- 163
Cdd:COG2211 97 llftapDLSPTGKLIYALVTYLLLGLAYTLVNIPYSALGAELTPdYEERTRLSSWRFAFAGLGGLLASVLPPPLVAAFGg 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 164 ------TIPFLVAAGVYILYTAILAFQFKKYPIEKkkvntEKPVTMLNAVRILRKDVVFLVALVGIILSNCGFSHLTTTV 237
Cdd:COG2211 177 daalgyRLTALIFAVLGLLAFLLTFFGTKERPVPE-----EEKVSLKESLKALLKNRPFLLLLLAYLLFFLALALVAALL 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 238 SQYFanAHIFQDGVTLFSYMLALNAIVVVVIQYPVIQICKKYTPLTSIMVGTLFVSGGLFGFGIV--ESTLGAAVCTIIF 315
Cdd:COG2211 252 LYYF--KYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLgpGNLWLLLVLAALA 329
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1267255154 316 TIGEVLMFSMTDVFIDDIA-VSHLK------GTYFGAMGF-SGIGAVIGPWFGGVLLDYYGYQNG 372
Cdd:COG2211 330 GIGLGAILVLPWAMLADVVdYDEWKtgrrreGLYFGIFTFaIKLGQALAGALAGLLLALFGYVAG 394
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
15-350 |
1.41e-26 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 109.29 E-value: 1.41e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 15 IIIGTLFARFATSMSIPFLAIYLTTVkGVSAGMTGAIIGTSALVGVFASFIGGNLSDRFGRNMIIIWSMIAWVFVFIGFS 94
Cdd:COG2814 15 LALGAFLSGLGIGIVLPALPLIAADL-GASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCA 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 95 FANHVLSFFLLNALNGLCRSFFEPTSRALLSDLTKPEYRLLVYNLRYGAINVGVAIGPLVGLQIGSAKS-TIPFLVAAGV 173
Cdd:COG2814 94 LAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGwRWVFLVNAVL 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 174 YILYTAILAFQFKKYPIEKKKvntekpvTMLNAVRILRKDVVFLVALVGIILSNCGFSHLTTTVSQYFANAHIFqdGVTL 253
Cdd:COG2814 174 ALLALLLLLRLLPESRPAARA-------RLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGL--SASA 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 254 FSYMLALNAIVVVVIQYPVIQICKKYTPLTSIMVGTLFVSGGLFGFGIVESTLGAAVCTIIFTIGEVLMFSMTDVFIDDI 333
Cdd:COG2814 245 AGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAEL 324
|
330
....*....|....*..
gi 1267255154 334 AVSHLKGTYFGAMGFSG 350
Cdd:COG2814 325 APPEARGRASGLYNSAF 341
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
15-357 |
7.45e-26 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 107.12 E-value: 7.45e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 15 IIIGTLFARFATSMSIPFLAIYLTTVKGVSAGMTGAIIGTSALVGVFASFIGGNLSDRFGRNMIIIWSMIAWVFVFIGFS 94
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 95 FANHVLSFFLLNALNGLCRSFFEPTSRALLSDLTKPEYRLLVYNLRYGAINVGVAIGPLVGLQIGSAKS-TIPFLVAAGV 173
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGwRAAFLILAIL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 174 YILYTAILAFQFKKYPIEKKKVNTEKPVTMLNAVRILRKDVVFLVALVGIILSNCGFSHLTTTvsqyFANAHIFQDGVTL 253
Cdd:pfam07690 161 SLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYL----PLYQEVLGLSALL 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 254 FSYMLALNAIVVVVIQYPVIQICKKY---TPLTSIMVGTLFVSGGLFGFGIVESTLGAAVCTIIFTIGEVLMFSMTDVFI 330
Cdd:pfam07690 237 AGLLLGLGGLLGAIGRLLLGRLSDRLgrrRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALV 316
|
330 340
....*....|....*....|....*...
gi 1267255154 331 DDIAVSHLKGTYFGAMG-FSGIGAVIGP 357
Cdd:pfam07690 317 SDLAPKEERGTASGLYNtAGSLGGALGP 344
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
21-387 |
1.69e-21 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 95.19 E-value: 1.69e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 21 FARFATSMSIPFLAIYLTTVKGVSAGMTGAIIGTSALVGVFASFIGGNLSDRFGRNMIIIWSMIAWVFVFIGFSFANHVL 100
Cdd:cd06174 6 FLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFW 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 101 SFFLLNALNGLCRSFFEPTSRALLSDLTKPEYRLLVYNLRYGAINVGVAIGPLVGLQIGSAKST---IPFLVAAGVYILY 177
Cdd:cd06174 86 LLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFgwrAVFLIAAALALLA 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 178 TAILAFQFKKYPIEKKKVNT-EKPVTMLNAVRILRKDVVFLVALVGIILSNCGFSHLTTTVSQYFANahIFQDGVTLFSY 256
Cdd:cd06174 166 AILLLLVVPDPPESARAKNEeASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLD--LGGLSVAVAGL 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 257 MLALNAIVVVVIQYPVIQICKKYTPLTSIMVGTLFVSG-GLFGFGIVESTLGAAVCTIIFTIGEVLMFSMTDVFIDDIAV 335
Cdd:cd06174 244 LLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMAlGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFP 323
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 1267255154 336 SHLKGTYFGAMGFSG-IGAVIGPWFGGVLLD-YYGYQNGFVVFSALAIFSTVAF 387
Cdd:cd06174 324 PEIRGTAFGLLNTFGfLGGAIGPLLAGFLLAaTFGLTGAFLVLAVLLLLAAILL 377
|
|
| PRK10054 |
PRK10054 |
efflux MFS transporter YdeE; |
29-383 |
8.44e-21 |
|
efflux MFS transporter YdeE;
Pssm-ID: 182213 Cd Length: 395 Bit Score: 93.27 E-value: 8.44e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 29 SIPFLAIYLTTVKGVSAGMTGAIIGTSALVGVFASFIGGNLSDRFGRNMIIIWSMIAWVFVFIGFSFANHVLSFFLLNAL 108
Cdd:PRK10054 26 TLPFMTIYLSRQYSLSVDLIGYAMTIALTIGVVFSLGFGILADKFDKKRYMLLAITAFASGFIAIPLVNNVTLVVLFFAL 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 109 NGLCRSFFEPTSRALLSDLTKPEYRLLVYNLRYGAINVGVAIGPLVGLQIGSAKSTIPFLVAAgvyilYTAILAFQFKKY 188
Cdd:PRK10054 106 INCAYSVFSTVLKAWFADNLSSTSKTKIFSLNYTMLNIGWTVGPPLGTLLVMQSINLPFWLAA-----ICSAFPLVFIQI 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 189 PIEKKKVNTEKPVTMLNAVRILRKDVVFLVALVGIILSNCGFSHLTTTVSQY---FANAHIFQDGVTLfsyMLALNAIVV 265
Cdd:PRK10054 181 WVQRSEKAIATETGSVWSPSVLLQDKALLWFTCSGFLASFVSGAFASCISQYvmvVADSDFAEKVVAV---VLPVNAAMV 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 266 VVIQYPVIQICKKYTPLTSIMVGTLFVSGGLFGFGIVESTLGA-AVCTIIFTIGEVLMFSMTDVFIDDIAVSHLKGTYFG 344
Cdd:PRK10054 258 VSLQYSVGRRLNAANIRPLMTAGTLCFVIGLVGFIFSGNSLLLwGMSAAVFTVGEIIYAPGEYMLIDHIAPPGMKASYFS 337
|
330 340 350
....*....|....*....|....*....|....*....
gi 1267255154 345 AMGFSGIGAVIGPWFGGVLLDYYGYQNGFVVFSALAIFS 383
Cdd:PRK10054 338 AQSLGWLGAAINPLVSGVILTTLPPWSLFVILALAIVAA 376
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
15-387 |
2.85e-20 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 91.50 E-value: 2.85e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 15 IIIGTLFARFATSMSIPFLAIYLTTvKGVSAGMTGAIIGTSALVGVFASFIGGNLSDRFGRNMIIIWSMIAWVFVFIGFS 94
Cdd:cd17489 1 ILLANFFFFLSFYLLLPVLPLYAHD-LGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 95 FANHVLSFFLLNALNGLCRSFFEPTSRALLSDLTKPEYRLLVYNLRYGAINVGVAIGPLVGLQIGSAKS-TIPFLVAAGv 173
Cdd:cd17489 80 LATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGfAVLFIVAAV- 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 174 yILYTAILAFQFKKYPIEKKKvnTEKPVTMLNAVRILRKDVvfLVALVGIILSNCGFSHLTTTVSQYFanAHIFQDGVTL 253
Cdd:cd17489 159 -LALLALLLVFLVKDPPPVAA--EEAEAGTRAFRRLVEKKV--LPPALILFLASIAYGAISTFLPLYA--AERGISNAGL 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 254 FsymLALNAIVVVVIQYPVIQICKKYTPLTSIMVGTLFVSGGLFGFGIVESTLGAAVCTIIFTIGEVLMFSMTDVFIDDI 333
Cdd:cd17489 232 F---FTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDL 308
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 1267255154 334 AVSHLKGTYFGAM-GFSGIGAVIGPWFGGVLLDYYGYQNGFVVFSALAIFSTVAF 387
Cdd:cd17489 309 VPPHRRGAANGTFfIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLALVLY 363
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
14-183 |
3.03e-18 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 85.71 E-value: 3.03e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 14 TIIIGTLFARFATSMSIPFLAIYLTTVKGVSAGMTGAIIGTSALVGVFASFIGGNLSDRFGRNMIIIWSMIAWVFVFIGF 93
Cdd:cd17325 203 ALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLL 282
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 94 SFANHVLSFFLLNALNGLCRSFFEPTSRALLSDLTKPEYRLLVYNLRYGAINVGVAIGPLVGLQIGSAKS-TIPFLVAAG 172
Cdd:cd17325 283 PLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGfATPFLAAAA 362
|
170
....*....|.
gi 1267255154 173 VYILYTAILAF 183
Cdd:cd17325 363 LLLLAAVLFLL 373
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
15-391 |
4.66e-18 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 84.92 E-value: 4.66e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 15 IIIGTLFArFATSMSIPFLAIYLTTVKGVSAGMTGAIIGTSALVGVFASFIGGNLSDRFGRNMIIIWSMIAWVFVFIGFS 94
Cdd:COG2271 15 LFLAYFLN-YLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFG 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 95 FANHVLSFFLLNALNGLCRSFFEPTSRALLSDLTKPEYRLLVYNLRYGAINVGVAIGPLVGLQIGSAKS-TIPFLVAAGV 173
Cdd:COG2271 94 FATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGwRAAFLILGLP 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 174 YILYTAilafqfkkypiekkkvntekpvtmlnavrilrkdVVFLVALVGIILSNCGFSHLTTTVSQYFANAHIFqdGVTL 253
Cdd:COG2271 174 GLLLAL----------------------------------LRFWLLALAYFLVYFALYGFLTWLPTYLVEVRGL--SLAQ 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 254 FSYMLALNAIVVVVIQYPVIQICKKY--TPLTSIMVGTLFVSGGLFGFGIVESTLGAAVCTIIFTIGEVLMFSMTDVFID 331
Cdd:COG2271 218 AGLLLSLPFLAGIVGSLLGGWLSDRLgrRRKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAA 297
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1267255154 332 DIAVSHLKGTYFGAMGFSG-IGAVIGPWFGGVLLDYYGYQNGFVVFSALAIFSTVAFPVLV 391
Cdd:COG2271 298 ELFPKKARGTASGLVNTFGfLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLL 358
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
17-388 |
5.19e-17 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 81.82 E-value: 5.19e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 17 IGTLFARFATSMSIPFLAIYLTTVkGVSAGMTGAIIGTSALVGVFASFIGGNLSDRFG-RNMIIIWSMIAWVFVFIGFSF 95
Cdd:cd17370 6 LVSLFADISYEMARSILPLFLVVL-GASAAAVGLIEGLAEALGSLLRLFSGYLSDRTGkRKPLVILGYGLSALAKPLLAL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 96 ANHVLSFFLLNALNGLCRSFFEPTSRALLSDLTKPEYRLLVYNLRYGAINVGVAIGPLVG---LQIGSAKSTIPFLVAAG 172
Cdd:cd17370 85 AGSWQLVLLLRILERLGKGIRTPPRDALLADATPPSGRGKAFGLHRALDTLGAVLGPLLAallLYLLGGNYRTIFLLAAI 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 173 VYILYTAILAFQFKKYPIEKKKVNTEKPVtmlnavRILRKDVVFLVALVGIILSNCGFSHltttVSQYFANAHIFQDGVT 252
Cdd:cd17370 165 PALLALLILLFVVKEYPRPPKLRKKSKKT------SLKKLPKAFWLYLLAVALFALGNFS----FAFLILRAQELGLSAA 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 253 LFSYMLALNAIVVVVIQYPVIQICKKYTPLTSIMVGTLFVSGGLFGFGIVESTLGAAVCTIIFTIGEVLMFSMTDVFIDD 332
Cdd:cd17370 235 LIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQESIERAAVAD 314
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 1267255154 333 IAVSHLKGTYFGAMGFS-GIGAVIGPWFGGVLLDYYGYQNGFVVFSALAIFSTVAFP 388
Cdd:cd17370 315 LVPAELRGTAYGLFNTVvGIGWLLASLIAGYLWDLISPSAAFLFSAVLALIALLLLL 371
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
20-386 |
1.74e-16 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 80.31 E-value: 1.74e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 20 LFARFATSMSIPFLAIYLTTVKGVSAGMTGAIIGTSALVGVFASFIGGNLSDRFGRNMIIIWSMIAWVFVFIGFSFANHV 99
Cdd:COG2223 14 FFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAVSY 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 100 LSFFLLNALNGLCRSFFEPTSRALLSDLTKPEYRLLVYNLRYGAINVGVAIGPLVGLQIGSAKS-TIPFLVAAGVYILYT 178
Cdd:COG2223 94 WLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGwRNAFLILGILLLVVA 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 179 AILAFQFKKYPIEKKKVNTEKPVTMLNAVRilrkDVVFLVALVGIILSNCGFSHLTTTVSQYFANAhiFQDGVTLFSYML 258
Cdd:COG2223 174 VLAWLFLRDPPAGAAAAAKASLRDQLEALR----DPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQ--FGLSAATAGLLA 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 259 ALNAIVVVVIQYPVIQICKKYTPLTSIMVGTLFVSGGLFGFGIVESTLGAA-VCTIIFTIGEVLMFSMTDVFIDDIAVSH 337
Cdd:COG2223 248 ALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALGSLWLFlVLFLLLGLALGGGNGAVFALVPDIFPTK 327
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 1267255154 338 LKGTYFGAMGFSG-IGAVIGPWFGGVLLDYYG-YQNGFVVFSALAIFSTVA 386
Cdd:COG2223 328 NAGAVYGLVGAAGgLGGFLGPLLFGALLDATGsYTAAFLVFAVLALVALVL 378
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
15-390 |
5.30e-16 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 78.81 E-value: 5.30e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 15 IIIGTLFARFATSMSIPFLAIYLTTVKGvSAGMTGAIIGTSALVGVFASFIGGNLSDRFGRNMIIIWSMIAWVFVFIGFS 94
Cdd:cd06173 4 LWLAQLLSALGDWIFTVALPWLVLQLTG-SALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 95 FANHVLSF-----FLLNALNGLCRSFFEPTSRALLSDLTKPEYRLLVYNLRYGAINVGVAIGPLV-GLQIGSAKSTIPFL 168
Cdd:cd06173 83 LLALLGSLslwllLVLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALgGLLVALLGPGGAFA 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 169 VAAGVYILYTAILAFQFKKYPIEKKKVNTEKPVTMLNAVRILRKDVVFLVALVGIILSNCGFShLTTTVSQYFAnAHIFQ 248
Cdd:cd06173 163 INALSFLLSALLLLFIRRPPPAAPGESSSLLLRDLREGLRYLRRSPLLRLLLLALALFALLGG-ALTVLLPLLA-KEVLG 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 249 DGVTLFSYMLALNAIVVVVIQYPVIQICKKYTPLTSIMVGTLFVSGGLFGFGIVESTLGAAVCTIIFTIGEVLMFSMTDV 328
Cdd:cd06173 241 GGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNT 320
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1267255154 329 FIDDIAVSHLKGTYFGAMG-FSGIGAVIGPWFGGVLLDYYGYQNGFVVFSALAIFSTVAFPVL 390
Cdd:cd06173 321 LLQLRVPDELRGRVFSVYNaLNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLLLL 383
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
24-392 |
8.00e-16 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 78.00 E-value: 8.00e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 24 FATSMSIPFLAIYLT--TVKGVSAGMTGAIIGTSALVGVFASFIGGNLSDRFGRNMIIIWSMIAWVFVFIGFSFANHVLS 101
Cdd:cd17330 10 LGFGIVFPVLPFYVRefNKLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNLWL 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 102 FFLLNALNGLCRSFFePTSRALLSDLTKPEYRLLVYNLRYGAINVGVAIGPLVGLQIGSAKS-TIPFLVAAGvyilytai 180
Cdd:cd17330 90 LFLARFLDGLTGGNV-SVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGyALPFLVAAA-------- 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 181 lafqfkkypiekkkvntekpVTMLNAVRILRKDVVFLVALVGIILSNCGFSHLTTTVSQYFANAhiFQDGVTLFSYMLAL 260
Cdd:cd17330 161 --------------------LALLNLVLVLFFLPPLRRLLLVYFLIALAFAGLESVFSLFLKDR--FGFSPSQIGLLLAL 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 261 NAIVVVVIQYPVI-QICKKYTPLTSIMVGTLFVSGGLFGFGIVESTLGAAVCTIIFTIGEVLMFSMTDVFIDDIAVSHLK 339
Cdd:cd17330 219 VGIAGILAQLLLIpRLAKRLGERKLLRLGLLLAIIGLLLLPFASSVPLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQ 298
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 1267255154 340 GTYFG-AMGFSGIGAVIGPWFGGVLLDYYGYQngfVVFSALAIFSTVAFPVLVV 392
Cdd:cd17330 299 GKAQGiIQSLQSLARIIGPLLAGPLYSFLGPG---VPFLLAAGLLLIALFLLSL 349
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
42-381 |
7.79e-15 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 75.30 E-value: 7.79e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 42 GVSAGMTGAIIGTSALVGVFASFIGGNLSDRFGRNMIIIWSMIAWVFVFIGFSFANHVLSFFLLNALNGLCRSFFEPTSR 121
Cdd:cd17474 30 GASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAGRALQGIGAAGLGPLAL 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 122 ALLSDLTKPEYRLLVYNLRYGAINVGVAIGPLVGLQIGSAKSTIPFLVAAGVYILYTAILAFqfkkYPIEKKKVNTEKPV 201
Cdd:cd17474 110 TLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAAISWRYPFFLLAALIPVAFLAILF----LLPEPKEKAKSSSA 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 202 TMLNAVRILRKDVVFLVALVGIILSNCGFSHLTTTVSQ-----YFANAHIFQDGVTLFSYMLALNAIVVVVIqypviqIC 276
Cdd:cd17474 186 TKLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFllellYGISPIIIGLLFAGWSVLLALGSLFVGRL------LK 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 277 KKYTPLTSIMVGTLFVSGGLFGFGIVESTLGAAVCTIIFTIGEVLMFSMTDVFIDDIAVSHLKGTYFGAMGFSG-IGAVI 355
Cdd:cd17474 260 KRFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRfLGQAV 339
|
330 340
....*....|....*....|....*.
gi 1267255154 356 GPWFGGVLLDYYGYQNGFVVFSALAI 381
Cdd:cd17474 340 GPLLFGLLLEIFGLSAPFLVGAAIAL 365
|
|
| MFS_MFSD6 |
cd17335 |
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ... |
24-387 |
4.44e-13 |
|
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 69.92 E-value: 4.44e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 24 FATSMSIPFLAIYLTTVkGVSAGMTGAIIGTSALVGVFASFIGGNLSDRFGRNMIIIW-SMIAWVFVFIGFSFANHvlSF 102
Cdd:cd17335 11 AALGSLLPFLSVYLKQL-GLSPTQIGILIGIRPFVRFLSAPLWGALADRFGKRKALLLlSLLAAVLFFLSLFFVAQ--IF 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 103 FLLNALNGLCRSFFEPTSrALLSDLTKpeYRLLVYNLRYGAINVGVAIG-----PLVGL---QIGSAKSTIPFLVAAGVY 174
Cdd:cd17335 88 WLLLLLVILGAFFSAPVV-PLVDSITL--QYLGEERERYGKQRLWGSIGfgiaaLLVGIlidRSSTYKNYTIAFYVFAVL 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 175 ILYTAILAFQFK-KYPIEKKKVNTEKPVTMLNAVRILrkdVVFLVALVgiilsnCGFSHLTTTVSQYFanaHIFQDG--V 251
Cdd:cd17335 165 MLLALLLALKFPfRPKHPEPNENTGGLLALLRNPRVL---AFLLVAFL------MGFGHGLIYSFLFW---HLQDLGgsK 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 252 TLFSYMLALNAIVVVVIQYPVIQICKKYTPLTSIMVGTLFVSGGLFGFGIVESTLGAAVCTII--FTIGEVLMFSMTdvF 329
Cdd:cd17335 233 TLIGLLWTVGVVSEIPFFFFSSRLIQRFGHVGLLYLGLLAYVVRWLLYSFLENPWLVLPIELLhgLTFALVWAAAVS--Y 310
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 330 IDDIAVSHLKGTYFGAMG--FSGIGAVIGPWFGGVLLDYYGYQNGFVVFSALAIFSTVAF 387
Cdd:cd17335 311 ASAAAPPGLRATAQGLLQglYFGLGGGLGSLIGGYLYEAFGARTTFRFFAIAALAGLLAF 370
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
17-385 |
2.29e-12 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 68.06 E-value: 2.29e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 17 IGTLFARFATSMSIPFLAIYLTTVKGVSAGM----TGAIIGTSALVGVFASFIGGNLSDRFGRNMIIIWSMIAWVFVFIG 92
Cdd:cd17391 3 LGNFFTGIGFSLIAPFLPLYIEQLGVTSGGLvelwSGLAFSSTFLVSAIFSPIWGRLADRYGRKPMLLRASLGMAIVIGL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 93 FSFANHVLSFFLLNALNGLCrSFFEPTSRALLSDLTKPEYRLLVYNLRYGAINVGVAIGPLVGLQIGSAKSTIPFLVAAG 172
Cdd:cd17391 83 MAFVTNVWQLLILRLLQGVF-SGYVPNATALIASQTPKEKSGWALGTLSTGVVAGTLIGPLLGGFLADLFGIRNVFFITG 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 173 VYILYTAILAFQFKK---YPIEKKKVNTEKPVTMlnavRILRKDVVFLVALVGIILSNCGFShLTTTVSQYFANAHIFQD 249
Cdd:cd17391 162 GLLFLAFLLTLFFVKedfKPVEKKKMVSTKEVWN----SVPNPSLLISLFVTTFIIQLANQS-IEPILTLYIRQLMGDAS 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 250 GVTLFSYMLALNAIVVVVIQYPVI-QICKKYTPLTSIMVGTLFVSGGLFGFGIVESTLGAAVCTIIFTIGEVLMFSMTDV 328
Cdd:cd17391 237 NLAFISGLVFSATGVSSLLSAPRLgKLGDRIGHHRILLGALLASALLYIPQAFVQTPWQLGILRFLLGLATGGLLPAINS 316
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 1267255154 329 FIDDIAVSHLKGTYFG-AMGFSGIGAVIGPWFGGVLLDYYGYQNGFVVFSALAIFSTV 385
Cdd:cd17391 317 LLAKITPKEVAGRIFGyNQSFQYLGNVAGPLLGSAIAAHFGYRAVFVVTALLVLLNAI 374
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
49-390 |
4.06e-12 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 67.26 E-value: 4.06e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 49 GAIIGTS-ALVGVFASFIGGNLSDRFGRNMIIIWSMIAWVFVFIGFSFANHVLSFFLLNALNGLCRSFFEPTSRALLSDL 127
Cdd:cd17328 36 AGLLQTVfIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQLLLFRALVGIGEASYSPIAPTIIADL 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 128 TKPEYRLLVYNLRYGAINVGVAIGPLVGLQIGSAKST--IPFLVAAGVYILyTAILAFQFKKYP----IEKKKVNTEKPV 201
Cdd:cd17328 116 FPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQATGGwrWAFRVTGVLGVL-LAILLLLFVREPprgaAEGGVMAKSTAT 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 202 TMLNAVRILRKDVVFLVALVGIILSNCGFSHLTTTVSQYFANAHIFQDG-----VTLFSYMLALNAIVVVVIQYPVIQIC 276
Cdd:cd17328 195 SFLADLKALAKNPSFILSTLGFTAVSFVTGALAFWAPTFFLRAFGVGDLssadvGLIFGAITCIAGVLGVLLGGILADRL 274
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 277 KKYTPLTSIMVG--TLFVSGGLFGFGIVESTLGAAVCTIIFTIGEVLMFsMTDVFIDDIAVSHLKGTYFG-AMGFSG--- 350
Cdd:cd17328 275 RRKTPRADPLVCavGLLAAAPFLFLALVLALSNLLLAWVLLFLGEFLLS-LNWAPVFAILLYVVIPTRRStASAIQIlls 353
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 1267255154 351 --IGAVIGPWFGGVLLDYYGYQNGFVVFSAL----AIFSTVAFPVL 390
Cdd:cd17328 354 hlLGDAGSPYLIGLISDLLRQNKDSPLAEAAslqyALLLCSFVLVL 399
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
14-392 |
4.37e-12 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 66.83 E-value: 4.37e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 14 TIIIGTLFARFATSMSIPFLAIYLTTVKGVSAGMTGAIIGTSALVGVFASFIGGNLSDRFGRNMIIIWSMIAWVFVFIGF 93
Cdd:cd17473 3 TLLLASTLTVMAGAAIAPALPAIAQHFVPNSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAG 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 94 SFANHVLSFFLLNALNGLCRSFFEPTSRALLSDLTKPEYRLLVYNLRYGAINVGVAIGPLVGLQIGSAKSTIPFLVAAGV 173
Cdd:cd17473 83 LFLDSLYALLASRALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALAEIGWRAPFLVYLLA 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 174 YILytAILAFQFKKYPIEKKKVNTEKPVTMLNAVRILRKDVVFLVALVGIILsncgFSHLTTTVSQYFANAHIFqdGVTL 253
Cdd:cd17473 163 LPV--LILVLLFLPEPARKSKSAASPGAATAAALPWKRVLPIYFLAFLAMLL----FYVIPIQLPFLLQERGGG--SAAL 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 254 FSYMLALNAIVVVVIQYPVIQICKKYTPLTSIMVGTLFVSGGLFGFGIVESTLGAAVCTIIFTIGEVLMFSMTDVFIDDI 333
Cdd:cd17473 235 IGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSL 314
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1267255154 334 AVSHLKG---TYFGAMGFsgIGAVIGPWFGGVLLDYYGyqNGFVVFSALAIFSTVAFPVLVV 392
Cdd:cd17473 315 VPPELRGramGIVTSAFF--LGQFLSPLVLGPLVNLTG--GLSGAFLILGVLALVLAIVLLL 372
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
15-387 |
9.83e-12 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 65.66 E-value: 9.83e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 15 IIIGTLFARFATSMSIPFLAIYLTTvKGVSAGMTGAIIGTSALVGVFASFIGGNLSDRFGRNMIIIWSMIAWVFVFIGFS 94
Cdd:cd17477 1 LLLSVALLGLGSGLLLPLLSLRLER-EGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 95 FANHVLSFFLLNALNGLCRSFFEPTSRALLSDLTKPEYRLLVYNLRYGAINVGVAIGPLVGLQIGSAKSTiPFLVAAGVY 174
Cdd:cd17477 80 LTDSPWVWFLLRFVMGIGLAGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFALGPLLLALVGTAGAL-PFLIAAVLL 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 175 ILYTAILAFQFKKYPIEKKkvntEKPVTMLNAVRILRkdvvflVALVGIILSNCGFSHLTTTVSQYFANAHIFQDGVtlf 254
Cdd:cd17477 159 LLALVPLLLTRRAAPEIEE----AESISLRRLLRIAP------LALLGAFVAGFLEGAFYSLLPLYGLRLGLSVAQA--- 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 255 SYMLALNAIVVVVIQYPVIQICKKYTPLTSIMVGTLFVSGGLFGFGIVESTLGA-AVCTIIFTIGEVLMFSMTDVFIDDI 333
Cdd:cd17477 226 ALLLAAFVLGGLLLQWPLGWLADRFDRRRVLLGCALLGALAALLLPLVPGLPLAlLVLLFLWGGAAGPLYTLALALAGDR 305
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 1267255154 334 AVSHLKGTYFGAMGFS-GIGAVIGPWFGGVLLDYYGYQNGFVVFSALAIFSTVAF 387
Cdd:cd17477 306 LPGDELVAANAALLLLyGLGSVIGPLLAGALMDAFGPHGLFLFLAAVALLFLLFL 360
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
42-387 |
4.78e-11 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 63.72 E-value: 4.78e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 42 GVSAGMTGAIIGTSALVGVFASFIGGNLSDRFGRNMIIIWSMIAWVFVFIGFSFANHVLSFFLLNALNGLCRSFFEPTSR 121
Cdd:cd17324 30 GVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHGGFWAIAA 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 122 ALLSDLTKPEYRLLVYNLRYGAINVGVAIGPLVGLQIGSAKS-TIPFLVAAGVYILYTAILAFQFKKYPIEKKkvnteKP 200
Cdd:cd17324 110 AYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGwRAAFLAIAVLALLAALLLWRLLPSLPPKKP-----GS 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 201 VTMLNAVRILRKDVVFLVALVGIILSNCGFSHLTTTVSQYFANAHIFQDGVTLFSYML--ALNAIVVVVIQYPViqicKK 278
Cdd:cd17324 185 LGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLfgVAGVVGSPLAGRLA----DR 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 279 YTPLTSIMVGTLFVSGGLFGFGIVESTLGAAVCTIIFTIGEVLMFSMTDVFIDDIAVSHlKGTYFGAMGFSG-IGAVIGP 357
Cdd:cd17324 261 GGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPEA-RGLASSLYLAAYnLGGALGA 339
|
330 340 350
....*....|....*....|....*....|
gi 1267255154 358 WFGGVLLDYYGYQNGFVVFSALAIFSTVAF 387
Cdd:cd17324 340 ALGGLVLDHGGWAGVGWVGAALLLLALLLA 369
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
9-150 |
6.29e-11 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 63.45 E-value: 6.29e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 9 HPLGMTIIIGTLFARFATSMSIPFLAIYLTTVKGVSAGMTGAIIGTSALVGVFASFIGGNLSDRFGRNMIIIWSMIAWVF 88
Cdd:COG2814 206 RPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLAL 285
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1267255154 89 VFIGFSFANHVLSFFLLNALNGLCRSFFEPTSRALLSDLTKPEYRLLVYNLRYGAINVGVAI 150
Cdd:COG2814 286 GLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPL 347
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
15-387 |
2.01e-10 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 61.79 E-value: 2.01e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 15 IIIGTLFARFATSMSIPFLAIYLTTVKGVSAGMTGAIIGTSALVGVFASFIGGNLSDR-FGRNMIIIWSMIAWVFVFIGF 93
Cdd:cd17471 1 LLLATLLTGLAGAFVLPYLSLFLTEELGASPLQIGIFMTLSALSGIVVSQWLGRLSDRgGDRKPLILLALLAGALGYLLF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 94 SFANH----VLSFFLLNALNGLCRSFFEPTSRALLSDLTKPEYRLLVYNLRyGAINVGVAIGPLVGLQIGSAKS-TIPFL 168
Cdd:cd17471 81 AFLRNywvlLLVGVVLLSLGAAAFPQLFALAREYADRSSGRDATLFNSVLR-AAFSLAWVIGPPLAFLLLDVLGfTGLFL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 169 VAAGVYILYTAILAFQFKKYPIEKkkVNTEKPVTMLNAVRILRkdvvFLVALVGIILSNCGFSHLTTTVSQYFANAhiFQ 248
Cdd:cd17471 160 LAALLYLVVALLVLFLLPSVKPPA--QKATPASSLVKAPVNRR----LLLLFAAFTLLFAANSMYIIAMPLYVTNE--LG 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 249 DGVTLFSYMLALNAIVVVVIQYPVIQICKKYTPLTSIMVGtlFVSGGLFGFGIVEST----------LGAAVCTIIFTIG 318
Cdd:cd17471 232 GSESWVGLLFGLAAALEIPIMLLAGLLAKRFGKRRLLLAG--FLAGVLFYLGLALATslwqlialqlLNAIFIGITAGLG 309
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1267255154 319 evlMFSMTDVFIDDIAVShlkGTYFGAMgfSGIGAVIGPWFGGVLLDYYGYQNGFVVFSALAIFSTVAF 387
Cdd:cd17471 310 ---ISYFQDLMPGQPGLA---TTLYSNA--SRIGSLLGGLLAGVIAQYFGYRAVFLVCAVLALLALVLL 370
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
11-390 |
3.82e-10 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 61.02 E-value: 3.82e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 11 LGMTIIIGTLFarFATSMSIPFLAIYLTTVK---GVSAGMTGAIIGTSALVGVFASFIGGNLSDRFGRNMIIIWSMIAWV 87
Cdd:COG0738 7 RRALIAIYLLF--FLWGFATALWGPLIPALKdafGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMA 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 88 FVFIGFSFANHVLSFFLLNALNGLCRSFFEPTSRALLSDLTkPEYRLLVYNLRYGAINVGVAIGPLVG----LQIGSAKS 163
Cdd:COG0738 85 LGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALG-PETAASRLNLLHAFFSLGALLGPLLGglliLLGLSLSW 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 164 TIPFLVAAGVYILYTAILAFqfkkYPIEKKKVNTEKPVTMLNAVRILRKDVVFLVALVGIILSNCGFSHLTTTVSQYFAN 243
Cdd:COG0738 164 HLPYLILAVLLLLLALLFLR----SKLPEIEEEEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKD 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 244 AHIFqdGVTLFSYMLALNAIVVVVIQYPVIQICKKYTPLTSIMVGTLFVSGGLFGFGIVESTLGAAVCTIIFTIGEVLMF 323
Cdd:COG0738 240 VLGL--SEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLSLMF 317
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1267255154 324 SMTDVFIDDIAVSHLKGTYFGAMGFSGIGAVIGPWFGGVLLDYYGYQNGFVVFSALAIFSTVAFPVL 390
Cdd:COG0738 318 PTIFSLALDGLGKRTAAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLVPLVCYLLILLLALAL 384
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
13-158 |
8.92e-10 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 60.30 E-value: 8.92e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 13 MTIIIGTLFARFATSMSIPFLAIYLTTVKGVSAGMTGAIIGTSALVGVFASFIGGNLSDRFGRNMIIIWSMIAWVFVFIG 92
Cdd:COG2211 231 LLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLL 310
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1267255154 93 FSFA--NHVLSFFLLNALNGLCRSFFEPTSRALLSDLTKPEYRL-------LVYNLRYGAINVGVAIGPLVGLQI 158
Cdd:COG2211 311 LFFLgpGNLWLLLVLAALAGIGLGAILVLPWAMLADVVDYDEWKtgrrregLYFGIFTFAIKLGQALAGALAGLL 385
|
|
| MFS_MelB_like |
cd17332 |
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ... |
32-382 |
2.25e-09 |
|
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 58.77 E-value: 2.25e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 32 FLAIYLTTVKGVSAGMTGAIIGTSALVGVFASFIGGNLSDRFGRNM---------IIIWSMIAWVFVFIGFSFANHVLS- 101
Cdd:cd17332 21 YLLFFYTDVLGLSAAAAGTIFLVARIIDAINDPLMGYLIDRTRSRWgrfrpwllwGAIPLALLFVLLFTTPDGSGTGKLi 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 102 -FFLLNALNGLCRSFFEPTSRALLSDLTK-PEYRLLVYNLRY-----GAINVGVAIGPLVGLQIGSAKSTIPFLVAAGVY 174
Cdd:cd17332 101 yALITYILLDLLYTLVNIPYTALIPELTDdPEERTSLTSWRMffatiGGLLVTVLPPPLVAYFGGGNASRGYFLTALIIG 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 175 ILYTAILAFQFKK-YPIEKKKVNTEKPVTMLNAVRILRKDVVFLVALVGIILSNCGFShLTTTVSQYFA--NAHIFQDGV 251
Cdd:cd17332 181 IIGIILLLICFFGtRERVVPPEEEKSKLPLLKSLKALLKNRPFLILLLAYLLYFLAFN-IVNTVLVYYFkyVLGGRAELV 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 252 TLFSYMLALnAIVVVVIQYPVIQICKKYTPLTSIMVGTLFVSGGLF---GFGIVESTLGAAVCTIIFTIGEVLMFSMTDV 328
Cdd:cd17332 260 LLLLLILSG-ALLALLPWPPLKKRFGKKKAFFIGLLLAILGLLLLFflpPGNLVLILVLAVLAGIGYGGANLLPWAMLAD 338
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 1267255154 329 FIDDIAVSHLK---GTYFGAMGFSG-IGAVIGPWFGGVLLDYYGYQNGFVVFSALAIF 382
Cdd:cd17332 339 VIDYGELKTGKrreGIFYSVMTFFRkLGLALAGALVGLILSLAGYVANAAAQSASALN 396
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
15-183 |
3.60e-09 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 57.94 E-value: 3.60e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 15 IIIGTLFArfATSMSIPFLAIYLTTVkGVSAGMTGAIIGTSALVGVFASFIGGNLSDRFGRNMIIIWSMIAWVFVFIGFS 94
Cdd:cd17370 206 LLAVALFA--LGNFSFAFLILRAQEL-GLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFA 282
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 95 FANHVLSFFLLNALNGLCRSFFEPTSRALLSDLTKPEYRLLVYNLRYGAINVGVAIGPLV-GLQIGSAKSTIPFLVAAGV 173
Cdd:cd17370 283 LGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPAELRGTAYGLFNTVVGIGWLLASLIaGYLWDLISPSAAFLFSAVL 362
|
170
....*....|
gi 1267255154 174 YILytAILAF 183
Cdd:cd17370 363 ALI--ALLLL 370
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
9-185 |
9.89e-09 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 56.50 E-value: 9.89e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 9 HPLGMTIIIGTLFARFATSMSIPFLAIY---LTTVKGVSAGMTGAIIGTSALVGVFASFIGGNLSDRFGRNMIIIWSMIA 85
Cdd:cd17391 200 PSLLISLFVTTFIIQLANQSIEPILTLYirqLMGDASNLAFISGLVFSATGVSSLLSAPRLGKLGDRIGHHRILLGALLA 279
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 86 WVFVFIGFSFANHVLSFFLLNALNGLCRSFFEPTSRALLSDLTKPEYRLLVYNLRYGAINVGVAIGPLVGLQIGSAKST- 164
Cdd:cd17391 280 SALLYIPQAFVQTPWQLGILRFLLGLATGGLLPAINSLLAKITPKEVAGRIFGYNQSFQYLGNVAGPLLGSAIAAHFGYr 359
|
170 180
....*....|....*....|.
gi 1267255154 165 IPFLVAAGVYILYTAILAFQF 185
Cdd:cd17391 360 AVFVVTALLVLLNAIWSFIFL 380
|
|
| MFS_SLC45_SUC |
cd17313 |
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ... |
24-387 |
1.64e-08 |
|
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340871 [Multi-domain] Cd Length: 421 Bit Score: 56.10 E-value: 1.64e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 24 FATSMSIPFLAIYLTTVkGVSAGMTGAIIGTSALVGVFASFIGGNLSDR----FGRNM--IIIWSMIAWVFVF------- 90
Cdd:cd17313 13 FGWALENSYVPPILQTL-GLSHALIGFVWTLGPILGLFVQPLVGSLSDRcnsrIGRRRpfILVGAPLAALGLIlipnaad 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 91 IGFSFANH---------VLSFFLLNALNGLCRSffePTsRALLSDLTKPEYRLLVYNLRYGAINVGVAIGPLVGLQIGS- 160
Cdd:cd17313 92 IGLALGDGprtwalvlfVLGIVLLDFAMNVCQG---PV-RALLPDLVPPEQRSKANGIINFMGGLGGVLGYLLGAILWDh 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 161 --------AKSTIPFLVAAGVYILYTAILAFQFKKYPI----EKKKVNTEKPVTMLNAVR-ILRKDVVFLVALVGIILSN 227
Cdd:cd17313 168 nwfgfalgGNLKVPFYIGAIILLVCVLVTLFFVKEPPLspeaGEHSENPSLGEVLKSLLKlLKIMPRSLLRLLLVIFFWW 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 228 CGFSHLTTTVSQYFANAH---------IFQDGVTLFSYMLALNAIVVVVIQYPVIQICKKYTPLTSIMVGTLFVSGGLFG 298
Cdd:cd17313 248 IAFFPFELFFTDYMGEEVyhgtsaassHYGAGVRMGAWGLLIFSLAFLIFSLPIGKLGKKIGRKKVYLIGLVLFAVGMAL 327
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 299 FGIVESTLGAAVCTIIFTIGEVLMFSMTDVFIDDIAVSHLK--GTYFGAM-GFSGIGAVIGPWFGGVLLDYYGYQNGFVV 375
Cdd:cd17313 328 MALVHNVTVALVLFALGGIGWATININPYPLVSDYHSESGRgqGTDTGLLnLAISLAQILVSLLAGPIIDVKGYGTVFPV 407
|
410
....*....|..
gi 1267255154 376 fsaLAIFSTVAF 387
Cdd:cd17313 408 ---AAVASFLSL 416
|
|
| MFS_TetA |
cd17388 |
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ... |
45-357 |
3.72e-08 |
|
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340946 [Multi-domain] Cd Length: 385 Bit Score: 54.95 E-value: 3.72e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 45 AGMTGAIIGTSALVGVFASFIGGNLSDRFGRNMIIIWSMIAWVFVFIGFSFANHVLSFFLLNALNGLCRSFFEpTSRALL 124
Cdd:cd17388 37 ATHYGVLLALYALMQFIFAPILGALSDRFGRRPVLLLSLAGAALDYLLMAFAPTLWWLYLGRIIAGITGATGA-VAAAYI 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 125 SDLTKPEYRLLVYNLRYGAINVGVAIGPLVGLQIGSAKSTIPFLVAAGVYILyTAILAFQF--------KKYPIEKKKVN 196
Cdd:cd17388 116 ADVTPPEQRARNFGLLGAAFGLGFIAGPALGGLLGEISPRAPFLVAAGLNGL-NFLLGLFVlpeslppeRRRAFRWRRAN 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 197 TEKPVTMLNAVRILRK--DVVFLVALVGiilsncgfsHLTTTVSQYFANAHIFQDGVTLfSYMLALNAIVVVVIQYPVIQ 274
Cdd:cd17388 195 PFGSLRWLTGFPGLLGllAVFFLIQLIG---------QVPATTWVLFTEDRFDWSPTMV-GLSLAVFGLLHALFQAFVTG 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 275 -ICKKYTPLTSIMVGTLFVSGGLFGFGIVESTLGAAVCTIIFTIGEVLMFSMTDVF---IDDIAVSHLKGTYFGAMgfsG 350
Cdd:cd17388 265 pIAKRLGEKRAILLGLAADALGFLLLAFATQGWMVFPILILLALGGIAGPALQGLLsrqVPENEQGELQGVLTSLT---S 341
|
....*..
gi 1267255154 351 IGAVIGP 357
Cdd:cd17388 342 LTSIIGP 348
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
9-183 |
3.99e-08 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 54.86 E-value: 3.99e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 9 HPLGMTIIIGTLFARFATSMSIPFLAIYLTTVKGVSAGMTGAIIGTSALVGVFASFIGGNLSDRFGRNMIIIWSMIAWVF 88
Cdd:cd17324 197 NPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAA 276
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 89 VFIGFSFANHVLSFFLLNALNGLCRSFFEPTSRALLSDLTkPEYRLLVYNLRYGAINVGVAIGPLVGLQIGSAKSTIPFL 168
Cdd:cd17324 277 LLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLA-PEARGLASSLYLAAYNLGGALGAALGGLVLDHGGWAGVG 355
|
170
....*....|....*
gi 1267255154 169 VAAGVYILYTAILAF 183
Cdd:cd17324 356 WVGAALLLLALLLAL 370
|
|
| MFS_MFSD9 |
cd17390 |
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ... |
24-389 |
4.26e-08 |
|
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340948 [Multi-domain] Cd Length: 350 Bit Score: 54.54 E-value: 4.26e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 24 FATSMSIPFLAIYLTTVkGVSAGMTGAIIGTSALVGVFASFIGGNLSDRFGRNMIIIWSMIAWVFVFIGFSFANHVLSFF 103
Cdd:cd17390 10 FGVSMILPLLSTHIRSL-GASPTVIGLIGSVYGALQLFSSPLVGSWSDVVGRRPVLLICLLLTALGYVLLGFSTSLALLF 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 104 LLNALNGLcrsfFEPT---SRALLSDLTKPEYRLLVYNLRYGAINVGVAIGPLVGLQIGSAKS--TIPFLVAAGVYILYT 178
Cdd:cd17390 89 LSRIPLGI----FKHTqslCKAYLSDLVSEQERSRVLGRFNAASSLGFILGPVVGGHLAETDGgfYYVALLCSAIFILNA 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 179 AILAFQFKKYPIekkkvntekpvtmLNAVRilrkdvvFLVALVGIILsncgFSHLTTTVSQyfanahIFQDGVTLFSYML 258
Cdd:cd17390 165 GLVWFLLSKLWD-------------LLLVR-------FLMGFSVLLF----RSNFSLYLEE------RFDLSPKTIGYLI 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 259 ALNAIVVVVIQYPVIQICKKYT--PLTSIMVGTLFVSGGLFGFGIVESTLGAAVCTIIFTIGEvlmfSMTDVFIDDIAVS 336
Cdd:cd17390 215 SYSGVLGALSGFLVGRILKLYKnnEYLLLLHSFILLALSLLGLALAPSIWLLVLCLTPLSISS----AVLRTCSTSLLLS 290
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 337 HLKGTYFGA-MGFS----GIGAVIGPWFGGVLLDYYGYQNGFV--VFSALAIFSTVAFPV 389
Cdd:cd17390 291 RGKSKERGTlLGVGqsvtSLARILAPLLSGLLQEFSVSGPGLLgaVLALAAILLMLARQR 350
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
12-105 |
4.84e-08 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 54.48 E-value: 4.84e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 12 GMTIIIGTLFARFATSMSIP-FLAIYLTTvKGVSAGMTGAIIGTSALVGVFASFIGGNLSDRFGRNMIIIWSMIAWVFVF 90
Cdd:cd17478 196 ALLLLLIIVFLRSWVLSSLTtFLPFYLVQ-RGYSLVFAGLLLSLFLFAGAIGTLIGGPLSDRFGRRRVIIASLLLAAPFL 274
|
90
....*....|....*
gi 1267255154 91 IGFSFANHVLSFFLL 105
Cdd:cd17478 275 LLFLLTPGIWSYILL 289
|
|
| PRK11646 |
PRK11646 |
multidrug efflux MFS transporter MdtH; |
31-366 |
7.14e-08 |
|
multidrug efflux MFS transporter MdtH;
Pssm-ID: 183255 Cd Length: 400 Bit Score: 53.91 E-value: 7.14e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 31 PFLAIYLTTVKGVSAGMTGAIIGTSALVGVFASFIGGNLSDRFGRNMIIIWSMIAWVFVFIGFSFANHVLSFFLLNALNG 110
Cdd:PRK11646 31 PLISIRFVDQLGWAAVMVGIALGLRQFIQQGLGIFGGAIADRFGAKPMIVTGMLMRAAGFATMAIAHEPWLLWLSCILSG 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 111 LCRSFFEPTSRALLSDLTKPEYRLLVYNLRYGAINVGVAIGPLVGLQIGSAKSTIPFLVAAGVYILYTAILAFQFKKYPI 190
Cdd:PRK11646 111 LGGTLFDPPRTALVIKLIRPHQRGRFFSLLMMQDSAGAVIGALLGSWLLQYDFRLVCATGAVLFVLAAAFNAWLLPAYKL 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 191 ekkkvnTEKPVTMLNAVRILRKDVVFLValvgIILSNCGFSHLTTTVSQYFA-NAHIFQDGVTLFSYMLALNAIVVVVIQ 269
Cdd:PRK11646 191 ------STVRTPVREGMTRVLRDKRFVT----YVLTLTGYYMLAVQVMLMLPiMVNDIAGSPSAVKWMYAIEACLSLTLL 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 270 YPVIQICKKYTPL-TSIMVGTLFVSGGLFGFGIVESTLGAAVCTIIFTIG--------EVLMFSMTDvfiddiavSHLKG 340
Cdd:PRK11646 261 YPIARWSEKRFRLeHRLMAGLLIMSLSMFPIGMVSNLQQLFTLICLFYIGsiiaeparETLSASLAD--------ARARG 332
|
330 340 350
....*....|....*....|....*....|
gi 1267255154 341 TYfgaMGFS----GIGAVIGPWFGGVLLDY 366
Cdd:PRK11646 333 SY---MGFSrlglALGGAIGYIGGGWLFDL 359
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
9-183 |
8.74e-08 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 53.77 E-value: 8.74e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 9 HPLGMTIIIGTLFARFATSMSIPFLAIYLTTVKGVSAGMTGAIIGTSALVGVFASFIGGNLSDRFGRNMIIIWSMIAWVF 88
Cdd:cd06173 207 SPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGL 286
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 89 VFIGFSFANHVLSFFLLNALNGLCRSFFEPTSRALLSDLTKPEYRLLVYNLRYGAINVGVAIGPLVGLQIGSAKSTIPFL 168
Cdd:cd06173 287 ALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVF 366
|
170
....*....|....*
gi 1267255154 169 VAAGVYILYTAILAF 183
Cdd:cd06173 367 LLAGALLLLAALLLL 381
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
4-183 |
5.29e-07 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 51.42 E-value: 5.29e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 4 KLQNIHPLGMTIIIGTLFARFATSMSIP-FLAIYLTTVKGVSAGMTGAIIGTSALVGVFASFIGGNLSDRFGRNMIIIWS 82
Cdd:cd17473 190 TAAALPWKRVLPIYFLAFLAMLLFYVIPiQLPFLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIG 269
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 83 MIAWVFVFIGFSFANHVLSFFLLNALNGLCRSFFEPTSRALLSDLTKPEYRLLVYNLRYGAINVGVAIGPLVGLQIGSAK 162
Cdd:cd17473 270 FALMALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLVLGPLVNLT 349
|
170 180
....*....|....*....|...
gi 1267255154 163 STI--PFLVAAGVYILYTAILAF 183
Cdd:cd17473 350 GGLsgAFLILGVLALVLAIVLLL 372
|
|
| PRK09874 |
PRK09874 |
multidrug efflux MFS transporter MdtG; |
17-385 |
6.88e-07 |
|
multidrug efflux MFS transporter MdtG;
Pssm-ID: 182127 [Multi-domain] Cd Length: 408 Bit Score: 51.07 E-value: 6.88e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 17 IGTLFARFATSMSIPFLAIYLTT--VKGVSA--GMTGAIIGTSALVGVFASFIGGNLSDRFGRNMIIIWSMIAWVFVFIG 92
Cdd:PRK09874 21 LGCFLTGAAFSLVMPFLPLYVEQlgVTGHSAlnMWSGLVFSITFLFSAIASPFWGGLADRKGRKIMLLRSALGMGIVMVL 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 93 FSFANHVLSFFLLNALNGLCRSFFEPTSRALLSDLTKPEYRLLVYNLRYGAINvGVAIGPLVGLQIGSAKSTIP--FLVA 170
Cdd:PRK09874 101 MGLAQNIWQFLILRALLGLLGGFVPNANALIATQVPRNKSGWALGTLSTGGVS-GALLGPLAGGLLADSYGLRPvfFITA 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 171 AGVYILYTAILAFQFKKY-PIEKKK-VNTEKPVTMLNAVRILRKdvVFLVALVGIILSNCGFSHLTTTVSQYFANAhifq 248
Cdd:PRK09874 180 SVLFLCFLVTLFCIRENFqPVSKKEmLHMREVVTSLKNPKLVLS--LFVTTLIIQVATGSIAPILTLYVRELAGNV---- 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 249 DGVTLFSYMLALNAIVVVVIQYPVIQICKKYTPLTSIMVGTLFVSGGL----------FGFGIVESTLGAAVCTIIFTIG 318
Cdd:PRK09874 254 SNIAFISGMIASVPGVAALLSAPRLGKLGDRIGPEKILITALIFSVLLlipmsfvqtpLQLGILRFLLGAADGALLPAVQ 333
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1267255154 319 EVLMFSMTdvfiddiavSHLKGTYFG-AMGFSGIGAVIGPWFGGVLLDYYGYQNGFVVFSALAIFSTV 385
Cdd:PRK09874 334 TLLVYNSS---------NQIAGRIFSyNQSFRDIGNVTGPLMGAAISANYGFRAVFLVTAGVVLFNAV 392
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
13-155 |
9.20e-07 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 50.65 E-value: 9.20e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 13 MTIIIGTLFARFATSMSIPFLAIyLTTVKGVSAGMTGAIIGTSALVGVFASFIGGNLSDRFGRNMIIIWSMIAWVFVFIG 92
Cdd:cd17323 2 FIISFLTFVVTFGSSIYSPALPQ-IAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIG 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1267255154 93 FSFANHVLSFFLLNALNGLCRSFFEPTSRALLSDLTKPEYRLLVYNLRYGAINVGVAIGPLVG 155
Cdd:cd17323 81 CALAPNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIG 143
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
16-132 |
1.28e-06 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 50.27 E-value: 1.28e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 16 IIGTLFARFATSMSIPFLAIYLTTVKGVSAGMTGAIIGTSALVGVFASFIGGNLSDRFGRNMIIIWSMIAWVFVFIGFSF 95
Cdd:cd17503 184 LLLSFLLGLGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAGLLLLALGTLLLAF 263
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 1267255154 96 ANH---VLSFFLLNALNGLCRSF-FEPTSRALLSDLTKPEY 132
Cdd:cd17503 264 LTPdtsLWLIILPLFIRGLGMGLvFMPLNTLALNSLPPEQI 304
|
|
| MFS_2 |
pfam13347 |
MFS/sugar transport protein; This family is part of the major facilitator superfamily of ... |
32-383 |
1.63e-06 |
|
MFS/sugar transport protein; This family is part of the major facilitator superfamily of membrane transport proteins.
Pssm-ID: 433134 [Multi-domain] Cd Length: 427 Bit Score: 50.00 E-value: 1.63e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 32 FLAIYLTTVKGVSAGMTGAIIGTSALVGVFASFIGGNLSD----RFGR-------NMIIIWSMIAWVFVFIGFSFANHVL 100
Cdd:pfam13347 19 YLLYFYTDVLGLSAAAVGLVLLVARLVDAFTDPIVGHIIDrtrtRWGRrrpwlllSAIILAVSFILLFTPPELGRAPLFI 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 101 SFFLLNALNGLCRSFFEPTSRALLSDLTK-PEYRLLVYNLR-----YGAINVGVAIGPLVGLQIGSAKSTIPFLVAAGVY 174
Cdd:pfam13347 99 WLLATYILLRIAYTFFEIPYWSLGPELTRdYDERTSLTSYRsffsvGGGLLAAALAFPLVLILGGTGLERKGYRIFALIG 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 175 -ILYTA---ILAFQFKKYPIEKKKVNTE--KPVTMLNAVRILRKDVVFLVALVGIILSNCGFShLTTTVSQYFANAHIFQ 248
Cdd:pfam13347 179 aVLMLLgviITAAGTKERVSMRSKEDTGqkEAGSLLDMLKEVFRNRAFLILLASFLLAALAMG-VLNGLLLYYFRYVLGN 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 249 DGVTLFSYMLA--LNAIVVVVIQYPVIQICKKYTPLTSIMVGTLFVSGGLFgFGIVESTLGAAVCTIIFTIGEVLMFSMT 326
Cdd:pfam13347 258 GFAASAFPLVFtiGALLGIPLWPPLAKRIGKKNTYILGALITIAGFALALL-LGPNNTLLFLVLYIIIGFGYGSSFFLPW 336
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1267255154 327 DVFIDDIAVSHLK------GTYFGAMGF-SGIGAVIGPWFGGVLLDYYGYQNGFVVFSALAIFS 383
Cdd:pfam13347 337 SMLADVVDYGELRtgkrreGTFFAMWSFiSKLATGVGLGVSGLLLSAFGYNAGDSVQSPQAVTA 400
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
15-183 |
1.76e-06 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 49.42 E-value: 1.76e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 15 IIIGTLFARFATSMSIPFLAIyLTTVKGVSAGMTGAIIGTSALVGVFASFIGGNLSDRFGRNMIIIWSMIAWVFVFIGFS 94
Cdd:COG0477 19 LALGTFLEGLDFTIVNVALPS-IAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCG 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 95 FANHVLSFFLLNALNGLCRSFFEPTSRALLSDLTKPEYRLLVYNLRYGAINVGVAIGPLVGLQIGSAKS-TIPFLVAAGV 173
Cdd:COG0477 98 LAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGwRWIFLINAPL 177
|
170
....*....|
gi 1267255154 174 YILYTAILAF 183
Cdd:COG0477 178 GLLALVLRLR 187
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
32-189 |
1.96e-06 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 49.49 E-value: 1.96e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 32 FLAIYLTTVKGVSAGMTGAIIGTSALVGVFASFIGGNLSDRFGRNMIIIWSMIAWVFVFIGFSFANH-VLSFFLLNALNG 110
Cdd:COG2223 227 WLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALGsLWLFLVLFLLLG 306
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 111 LCRSFFEPTSRALLSDLTKPEYRLLVYNLRYGAINVGVAIGP-LVGLQIGSAKS-TIPFLVAAGVYILYTAILAFQFKKY 188
Cdd:COG2223 307 LALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPlLFGALLDATGSyTAAFLVFAVLALVALVLTLLLYRRP 386
|
.
gi 1267255154 189 P 189
Cdd:COG2223 387 R 387
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
15-385 |
2.60e-06 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 49.14 E-value: 2.60e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 15 IIIGTLFARFATSMSIPFLAIYLTTVkGVSAGMTGAIIGTSALVGVFASFIGGNLSDRFGRNMIII-----WSMIAWVFV 89
Cdd:cd17490 1 FLIIVFLFWFSQYVYVPFLSPYAESL-GASLSMIGIILGAYGISQMLLRIPLGILSDRIGKRKLFIiigllFTVLASLIM 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 90 FigfsFANHVLSFFLLNALNG-----------LCRSFFEPtsrallSDLTKPEYRLLVYNlrygaiNVGVAIGPLVGLQI 158
Cdd:cd17490 80 I----LFPSPWGLLIARFLSGiaaatwvsftvLYASYFPP------DEAAKAMGLINLVN------NLGQLIAFLIGGLI 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 159 GSAKS-TIPFLVAAGVYILyTAILAFQFKKYPIEKKKVNTEKPvtmlNAVRILRKDVVFLVALVGIILSNCGFSHLTTTV 237
Cdd:cd17490 144 AEHFGmRAPFLLAALAGVL-GFILSLFIKEERREKKPVLTELK----ELLSVLKDKKLLFFSLLAILQQMITFSTTFGFT 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 238 SQYFAN--AHIFQDGVTLFSYMLalnaIVVVVIQYPVIQICKKYTPLTSIMVGTLFVSGGLFGFGIVESTLGAAVCTIIF 315
Cdd:cd17490 219 PLIAKQlgASSFQLGLLSIIYLL----PNALASLLSGTLFYKKLGERNTIIIGFLLLGAYCFLIPFAPNLTLLYLLQALN 294
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1267255154 316 TIGEVLMFSMTDVFIDDIAVSHLKGTyfgAMGF----SGIGAVIGPWFGGVLLDYYGYQNGFVVFSALAIFSTV 385
Cdd:cd17490 295 GFGTGILFPLLMSLSIEGVPAEQRST---AMGFfqaiYALGMFLGPVLVGIISEAFGLQTGFFVIGVIALLAAI 365
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
10-185 |
5.28e-06 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 47.97 E-value: 5.28e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 10 PLGMTIIIGTLFARFATSMSIPFLAIYLTTVKGVSAGMtgaIIGTSALVGVFASFIGGNLSDRFGRNMIIIWSMIAWVFV 89
Cdd:cd17489 194 KKVLPPALILFLASIAYGAISTFLPLYAAERGISNAGL---FFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALG 270
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 90 FIGFSFANHVLSFFLLNALNGLCRSFFEPTSRALLSDLTKPEYRLLVYNLRYGAINVGVAIGPLV-GLQIGSAKSTIPFL 168
Cdd:cd17489 271 LLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLlGLVAELFGYRAMFL 350
|
170
....*....|....*..
gi 1267255154 169 VAAGVYILYTAILAFQF 185
Cdd:cd17489 351 LAAVVVLLALVLYIFLL 367
|
|
| PRK08633 |
PRK08633 |
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated |
7-393 |
6.41e-06 |
|
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated
Pssm-ID: 236315 [Multi-domain] Cd Length: 1146 Bit Score: 48.38 E-value: 6.41e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 7 NIHPLgmtIIIGTLFARFATSMSIPFLAIylttvkgVSAGMTgaiigtsaLVGVFASFIGGNLSDRFGRNMIIIWSMIAW 86
Cdd:PRK08633 26 LGHKI---LIQNTLIKAYDGSEQVILTAI-------VNALFL--------LPFLLLSSPAGFLADKFSKNRVIRIVKLFE 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 87 VFV----FIGFSFANHVLSFFLLnALNGLCRSFFEPTSRALLSDLTKPEyRL-----LVYNLRYGAINVGVAIGPLVgLQ 157
Cdd:PRK08633 88 VGLtlliVLAYYLGWFWLAFAVT-FLLGAQSAIYSPAKYGIIPELVGKE-NLsrangLLEAFTIVAILAGTALFSFL-FE 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 158 IGSAKSTIPFLVA---AGVYILYTAIL----AFQFKK----YPIEKKKVNTEKPVTMLNAVRILRKDVVFLVALVGIILS 226
Cdd:PRK08633 165 SVNGNTPSEILGRiapAGLVLLAVAVLglifAYRLPKvpaaAPEVFDKKKYLFPKLLWRNLKLLRSDRVLWLAIIGLSYF 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 227 nCGFSHLTTTVSQYFANAHIFQDGVTLFSYMLALNAIVVVVIQYPVIQICKKYTPLTSIMVGTLFVSGGLFGFGIVESTL 306
Cdd:PRK08633 245 -WFISQLAQANFPAYAKEVLGLDNTFQVQYLLAASAIGIGIGSLLAGRLSGRHIELGLVPLGALGLALSLFLLPTAPSLA 323
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 307 GAAVCTIIFTIGEVLMFSMTDVFIDDIAVSHLKGT---------YFGAMGFSGIgavigpwfgGVLLDYYGyqngfvvFS 377
Cdd:PRK08633 324 SVLVLFFLFGFSAGLFIVPLNALIQFRAPEKELGKvlaannflqNVGMLLFLAL---------TTLFSGLG-------LS 387
|
410
....*....|....*.
gi 1267255154 378 ALAIFSTVAFPVLVVT 393
Cdd:PRK08633 388 PAGLFYLIALVTLIGT 403
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
42-390 |
8.68e-06 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 47.58 E-value: 8.68e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 42 GVSAGMTGAIiGTSALVGV-FASFIGGNLSDRFGRNMIIIWSMIAWVFVFIGFSFANHVLSFFLLNALNGLCRSFFEPTS 120
Cdd:cd17365 30 GLSPAQLGPV-GSAALFGMaIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRFLTGLGLGAAMPNA 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 121 RALLSDLTKPEYRLLVYNLRYGAINVGVAIGPLVGLQIGSAKSTIPFLVAAGVYILYTAILAFqfkkypiekkkvntekp 200
Cdd:cd17365 109 ITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLLGGVPPLILLPLLR----------------- 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 201 VTMLNAvrilrkdVVFLVALVGIILSNCGFSHLTTTVSQYFANAHIFqdgVTLFSYMLALNAIVVVVIQypviqicKKYT 280
Cdd:cd17365 172 GTLLLW-------VTFFMGLLLVYLLNSWLPKLMVEAGYSLSQALTI---TLLLNIGGVIGSLLLGWLA-------DRFG 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 281 PLTSIMVGTLFVSGGLFGFGiVESTLGAAVCTIIFTIG------EVLMFSMTDVFIDdiavSHLKGTYFGAMGFSG-IGA 353
Cdd:cd17365 235 PKRVLALFFALGAVSLALLG-VSPASLVLLYVLVFLAGacvngaQVGLYALAARFYP----TEVRATGVGWALGVGrLGA 309
|
330 340 350
....*....|....*....|....*....|....*...
gi 1267255154 354 VIGPWFGGVLLDY-YGYQNGFVVFSALAIFSTVAFPVL 390
Cdd:cd17365 310 ILGPLLGGLLLAAgLGPESVFLALAIPAALGALAVLLL 347
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
42-386 |
1.06e-05 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 47.18 E-value: 1.06e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 42 GVSAGMTGAIIGTSALVGVFASFIGGNLSDRFGRNMIIIWSMIAWVFVFIGFSFANHVLSFFLLNALNGLCRSFFEPTSR 121
Cdd:cd17319 34 GLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFLLGVAEAGFFPGAI 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 122 ALLSDLTKPEYRLLVYNLRYGAINVGVAIGPLVGLQIGSAKSTIP-FLVAAGVYILYTAILAFQFKKypiekkkvntekp 200
Cdd:cd17319 114 KALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWaFIIEGLLGLLLAVLWWFYLRQ------------- 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 201 vtmlnavrilrkdvvFLVALVGIILSNCGFSHLTTTVSQYFANAHIFQD-GVTLFSYMLALNAIVVVVIQYPVIQICKKY 279
Cdd:cd17319 181 ---------------VWGLALGYFGINYALYGLLTWLPTYLKQARGFSLkQVGLLAAIPFLAGAIGMILGGRLSDRLLRG 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 280 TPLTSIMVGTLFVSGGLFGFGIVESTLGAAVCTIIFTIGEVLMFSMTDVFIDDIAVSHLKGTYFGAMGFSG-IGAVIGPW 358
Cdd:cd17319 246 ARRLVIIIGLLLAAVGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGnLGGFVAPL 325
|
330 340
....*....|....*....|....*....
gi 1267255154 359 FGGVLLDY-YGYQNGFVVFSALAIFSTVA 386
Cdd:cd17319 326 LIGYLVDAtGSYTAAFLFLAAVALLAALL 354
|
|
| BtlA |
COG2270 |
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ... |
30-131 |
1.22e-05 |
|
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];
Pssm-ID: 441871 [Multi-domain] Cd Length: 424 Bit Score: 47.07 E-value: 1.22e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 30 IPFLAIYLTTVKGVSAGMTGAIIGTSALVGVFASFIGGNLSDRFGRNMIIIWSMIAWVFVFIGFSFANHVLSFFLLNALN 109
Cdd:COG2270 258 IAFAGIYAAGVLGFSTTELIVFGLLVQIVAALGALLFGRLDDRIGPKRVILVSLVIWIVVCLAAYFLTTALAFWILGLLI 337
|
90 100
....*....|....*....|....*
gi 1267255154 110 GLcrsFFEPT---SRALLSDLTKPE 131
Cdd:COG2270 338 GL---VMGGIqalSRSLLARLIPPG 359
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
32-183 |
1.75e-05 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 46.41 E-value: 1.75e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 32 FLAIYLTTVKGVSAGMTGAIIGTSALVGVFASFIGGNLSD-RFGRNMIIIWSMIAWVFVFIGFSFANHVLSFFLLNALNG 110
Cdd:cd17474 220 YLPFLLELLYGISPIIIGLLFAGWSVLLALGSLFVGRLLKkRFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFG 299
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1267255154 111 LCRSFFEPTSRALLSDLTKPEYRLLVYNLRYGAINVGVAIGPLV-GLQIGSAKSTIPFLVAAGVYILYTAILAF 183
Cdd:cd17474 300 LGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLfGLLLEIFGLSAPFLVGAAIALAAAVLLAL 373
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
9-183 |
1.88e-05 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 46.37 E-value: 1.88e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 9 HPLGMTIIIGTLFARFATS-MSIPFLAIYLTTVKGVSAGMTGAIIGTSALVGVFASFIGGNLSDRFGRNMIIIWSMIAW- 86
Cdd:cd17369 226 HWRALLLAIGLRLAENVLFyLFTTFALSYATQTLGVDRSTVLLAVLIASVVAAITIPLFGWLSDRVGRRPVYLAGALLAa 305
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 87 VFVFIGFSF----ANHVLSFFLLNALNGLCRSFFEPTSrALLSDLTKPEYRL----LVYNLryGAInVGVAIGPLVGLQI 158
Cdd:cd17369 306 LFAFPFFWLldtgSTWLIVLAAVVVLGVLHGMMYGPQA-AFLAELFPTRVRYtgasLGYQL--GAI-LGGGFAPLIATAL 381
|
170 180
....*....|....*....|....*
gi 1267255154 159 GSAKSTIpflVAAGVYILYTAILAF 183
Cdd:cd17369 382 VAATGSW---WPVALYLAALAVISL 403
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
211-387 |
5.83e-05 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 44.96 E-value: 5.83e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 211 RKDVVFLVALVGIILSNCGFSHLTTTVSQYfanAHIFQDGVTLFSYMLALNAIVVVVIQYPVIQICKKYTPLTSIMVGTL 290
Cdd:COG2814 7 RRWLALLALALGAFLSGLGIGIVLPALPLI---AADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 291 FVSGGLFGFGIVESTLGAAVCTIIFTIGEVLMFSMTDVFIDDIAVSHLKGTYFGAMGFS-GIGAVIGPWFGGVLLDYYGY 369
Cdd:COG2814 84 LFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGlGLGPALGPLLGGLLADLFGW 163
|
170
....*....|....*...
gi 1267255154 370 QNGFVVFSALAIFSTVAF 387
Cdd:COG2814 164 RWVFLVNAVLALLALLLL 181
|
|
| MFS_SLC22A18 |
cd17331 |
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ... |
36-385 |
8.24e-05 |
|
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 44.52 E-value: 8.24e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 36 YLTTVKGVSAGMTGAIIGTSALVGVFASFIGGNLSDRFGRNMIIIWSMIAWVFVFIGFSFANHVLSFFL----LNALNGL 111
Cdd:cd17331 25 YLTKKLGVDSVVFGYLQTTFSVLQLVGGPLFGRFGDLFGPRAALVLSFLSSALSYLLLAFASSVPMLFLsrlpSVFMHAM 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 112 crsffePTSRALLSDLTKPEYR---LLVYNLRYGainVGVAIGPLVGLQIGSAKST-IPFLVAAGVYILyTAILAFQF-- 185
Cdd:cd17331 105 ------QAAQMVVTDLTDPGERaaaLGRLGLSYG---IGMVVGSFLGGLLTKKFGEqAAALVAAVGSLL-SIVLVILLip 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 186 -KKYPIEKKKVNTEKPV----TMLNAVRILRKDVVFLVALVgIILSNCGFSHLTTTVSQYFANahIFQDGVTLFSYMLAL 260
Cdd:cd17331 175 sNTKSKREKEAKESASPpsvfNLKEILRLLRLPGVAFLLLV-KLLSGLPIGMFQSMFSLVAMD--FFGLTPEENGYLMSY 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 261 NAIVVVVIQYPVIQI-CKKYTPLTSIMVGTLFVSGGLFGFGIVESTLGAAVCTIIFTIGEVLMFSMTDVFIDDIAVSHLK 339
Cdd:cd17331 252 AGVLGMVVQGLLVGPlTKRFGERSLLKLSVALLAIGYLLLAFVTTVWQLLVLLLPLVIGGSVLYTVITSLLTKAVPPEDT 331
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 1267255154 340 GTYFG-AMGFSGIGAVIGPWFGGVLLDYYGYQN----GFVVFSALAIFSTV 385
Cdd:cd17331 332 GTALGlSHALFSLVRTVSPTIGGALLQAYGFPSfgllGAAINGLLTVYLLL 382
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
42-386 |
8.34e-05 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 44.48 E-value: 8.34e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 42 GVSAGMTGAIIGTSALVGVFASFIGGNLSDRFGRNMIIIWSMIAWVFVFIGFSFANHVLSFFLLNALNGLCRSFFEPTSR 121
Cdd:COG2807 49 GLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGIAVGNVLLP 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 122 ALLSDLTkPEYRLLVYNLRYGAINVGVAIGPLVGLQIGSAKS-TIPFLVAAGVYILYTAILAFQFKKYPIEKKKVNTEKP 200
Cdd:COG2807 129 GLIKRWF-PDRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGwRGALAVWALLALLALLLWLPLLRRRPAAAAAAPAAAS 207
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 201 VtmlnaVRILRKDVVFLVALVGiILSNCGFSHLTTTVSQYFANAHIfqdGVTLFSYMLALNAIVVVVIQYPVIQICKKYT 280
Cdd:COG2807 208 L-----RSLWRSPLAWLLTLFF-GLQSLLYYAVVAWLPPILRDAGL---SAATAGLLLSLFQLAGIPGSLLVPLLADRLG 278
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 281 PLTSIMVGTLFVSGGLFGFGIVESTLGAAVCTIIFTIGEVLMFSMTDVFIDDIA-----VSHLKGTyfgAMGFSGIGAVI 355
Cdd:COG2807 279 DRRPLLLLLGLLGLAGLLGLLLAPGSLPWLWAVLLGLGQGGLFPLALTLIGLRArtpaeAAALSGM---AQSVGYLLAAL 355
|
330 340 350
....*....|....*....|....*....|..
gi 1267255154 356 GPWFGGVLLDYYG-YQNGFVVFSALAIFSTVA 386
Cdd:COG2807 356 GPLLVGALHDATGsWTAALLLLAALAVLMLVA 387
|
|
| MFS_DtpA_like |
cd17346 |
Dipeptide and tripeptide permease A (DtpA)-like subfamily of the Major Facilitator Superfamily ... |
33-386 |
1.04e-04 |
|
Dipeptide and tripeptide permease A (DtpA)-like subfamily of the Major Facilitator Superfamily of transporters; The DtpA-like subfamily includes four Escherichia coli proteins: dipeptide and tripeptide permeases A (DtpA, TppB or YdgR), B (DtpB or YhiP), C (DtpC or YjdL), and D (DtpD or YbgH). They are proton-dependent permeases that transport di- and tripeptides. DtpA and DtpB display a preference for di- and tripeptides composed of L-amino acids. DtpC shows higher specificity for dipeptides compared to tripeptides, and prefers dipeptides containing a C-terminal lysine residue. The DtpA-like subfamily belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340904 [Multi-domain] Cd Length: 399 Bit Score: 44.10 E-value: 1.04e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 33 LAIYLTT--VKGVSAGMTGAIIGTSALVGVFASFIGGNLSDRF-GRNMIIIWSMIAWVF-VFIGFSFANHVLSFFLLNAL 108
Cdd:cd17346 25 LILYLTAqlGDGFSEADAASIYGAYTALVYLTPIIGGWLADKVlGARRTVFIGGILMALgYLLLALSPFSVSMLYLGLAL 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 109 NGLCRSFFEPTSRALLSDLTKPEYRLL--VYNLRYGAINVGVAIGPLVGLQIGSAKS-TIPFLVAAGVYILYTAILAFQF 185
Cdd:cd17346 105 IIVGNGLFKPNISSLVGKLYDENDPRRdsGFSIFYMGINLGAFLAPLLCGTLGDNYGyHYGFGLAAVGMLLGLLIFLLGR 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 186 KKYPiEKKKVntekpvtmlnavrilrkdVVFLVALVGIILSNCGFSHLTTTVSQYFA-NAHIFQDGVTL-FSYMLALNAI 263
Cdd:cd17346 185 KKLL-ERKKM------------------LAIIILFLFAVVFWAIYEQAGTSLALFADeNVDRLLGGFTIpPSWFQSLNPL 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 264 VVVVIQYPVIQI-----CKKYTP-----------LTSIMVGTLFVSGGLFGFGIVESTLGAAVCTIIFTIGEVLMFSMTD 327
Cdd:cd17346 246 FIILLAPILAALwtklgKRGKDPsiptkfalgllLLGLSFLLMVLAASFAGGSGKVSALWLVLSYFLQTLGELCLSPVGL 325
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1267255154 328 VFIDDIAVSHLKGTYFGAMGFS-GIGAVIGPWFGGVLLDYY-------GYQNGFVVFSALAIFSTVA 386
Cdd:cd17346 326 SMITKLAPAKFAGFMMGLWFLAsALGNILAGYLAGFYAQPKdplasalVYTDYFGLIGVIALVAGII 392
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
32-373 |
1.18e-04 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 43.90 E-value: 1.18e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 32 FLAIYLTTVKGVSAGMTGAIIGTSALVGVFASFIGGNLSDRFGRNMIIIWSMIAWVFVFIGFSFANHVLSFFLLNALNGL 111
Cdd:TIGR00881 16 LAMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLWVMAALWALNGI 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 112 CRSFFEPTSRALLSDLTKPEYRLLVYNLRYGAINVGVAIGPLVGL----QIGSAKSTipFLVAAGVYILYtAILAFQFKK 187
Cdd:TIGR00881 96 FQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLVLfgiaELYSWHWV--FIVPGIIAIIV-SLICFLLLR 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 188 -------------YPIEKKKVNTEKPVTMLNAVRILRKDVVFLVALVGIILSNCGFSHLTTTVSQYFANAHIFQDGVTL- 253
Cdd:TIGR00881 173 dspqscglppaeeMPNEEPDGDAEKKEEELTKKQIFLQYVLLNKVLWYISLGYVFVYVVRTGILDWSPLYLTQEKGFSKe 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 254 ----FSYMLALNAIVVVVIQYPVIQICKKYT--PLTSIMVGTLFVSGGLFGFGIVESTLGAAVCTII---FTIGEVLMFS 324
Cdd:TIGR00881 253 kaswAFTLYELGGLVGTLLAGWLSDKLFNGRrgPLAVFFMALIIVSLLVYWLNPAANPLMDLICLFAlgfLVYGPQMLIG 332
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 1267255154 325 MTDVfidDIAVSHLKGTYFGAMGF-SGIGAVIGPWFGGVLLDYYGYQNGF 373
Cdd:TIGR00881 333 VIAS---ELAPKKAAGTAAGFVGFfAYLGGILAGLPLGYLADGFGWAGAF 379
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
13-382 |
1.21e-04 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 43.74 E-value: 1.21e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 13 MTIIIGTLFARFATSMSIPFLAIYLTTV--KGVSAGMTGAIIGTSALVGVFASFIGGNLSDRFGRNMIIIWSMIAWVFVF 90
Cdd:cd17316 1 LLLAGLGWFFDAYDFFLIGFVAPVLAAEfsLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLAT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 91 IGFSFANHVLSFFLLNALNGLCRSFFEPTSRALLSDLTKPEYRllvyNLRYGAINVGVAIGPLVGLQIGSAKSTIPFLVA 170
Cdd:cd17316 81 LLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRR----GFALGLLQSGWALGALLAALVASLLIPLLSGDW 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 171 AGVYILYTAILafqfkkypiekkkvntekpvtMLNAVRILRKDVVFLVALVGIILSNcgfSHLTTTVSQYFANAHIFQDG 250
Cdd:cd17316 157 GWRILFLIGAL---------------------PALLALLLRRRTLLLILLWFFISFG---YYGLTTFLPTYLQTVLGLSP 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 251 VTLFSYMLALNAIVVVVIqYPVIQICKKYTPLTSIMVGTL--FVSGGLFGFGIVESTLGAAVCTIIFTIGEVLMFSMTDV 328
Cdd:cd17316 213 ATSSLYLLLISLGALVGA-LIAGLLSDRIGRKKTLVIGLIlsGILALPLFYLLSGSPTLLLLLLFILSFFVGGVWGALYA 291
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 1267255154 329 FIDDIAVSHLKGTYFG-AMGFSGIGAVIGPWFGGVLLDYYGYQNGFVVFSALAIF 382
Cdd:cd17316 292 YLAELFPTEVRATGVGlSYNLGRLGGGGAPPLIALLLASTGGTGVPALILALLAI 346
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
24-226 |
1.31e-04 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 43.77 E-value: 1.31e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 24 FATSMSIPFLAIYLTTVKGVSAGMTGAIIGTSALVGVFASFIGGNLSDRFGRNMIIIWSMIAWVFVFIGFSFANHVLSFF 103
Cdd:cd17475 9 SLVAQGIPALAPFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLL 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 104 LLNALNGLCRSFFEPTSRALLSDLTKPEYRLLVYNLRYGAINVGVAIGPLVGLQIGSAKSTIPFLVAAGVYILYTAILAF 183
Cdd:cd17475 89 VLLFLVGAGYGSVQPGGGRAIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVVAGLVSILAAVLFW 168
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 1267255154 184 QFKKYPIEKKKVNTEKPVTMLNAVRILRKDVVFLVALVGIILS 226
Cdd:cd17475 169 LFYREPPAASAATESASTLLRSLKEVLRNRDVWLIAIAGALLV 211
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
220-387 |
2.21e-04 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 43.18 E-value: 2.21e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 220 LVGIILSNCGFSHLTTTVSQYFAnaHIFQDGVTLFSYMLALNAIVVVVIQYPVIQICKKYTPLTSIMVGTLFVSGGLFGF 299
Cdd:pfam07690 2 FLAAFLAALGRSLLGPALPLLLA--EDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 300 GIVESTLGAAVCTIIFTIGEVLMFSMTDVFIDDIAVSHLKGTYFG-AMGFSGIGAVIGPWFGGVLLDYYGYQNGFVVFSA 378
Cdd:pfam07690 80 LFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGlVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAI 159
|
....*....
gi 1267255154 379 LAIFSTVAF 387
Cdd:pfam07690 160 LSLLAAVLL 168
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
244-391 |
2.25e-04 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 43.18 E-value: 2.25e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 244 AHIFQDGVTLFSYMLALNAIVVVVIQYPVIQICKKYTPLTSIMVGTLFVSGGLFGFGIVESTLGAAVCTIIFTIGEVLMF 323
Cdd:cd06174 23 LQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFWLLLLGRFLLGLGSGLID 102
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1267255154 324 SMTDVFIDDIAVSHLKGTYFGAM-GFSGIGAVIGPWFGGVLLDY--YGYQNGFVVFSALAIFSTVAFPVLV 391
Cdd:cd06174 103 PAVLALIADLFPERERGRALGLLqAFGSVGGILGPLLGGILASSlgFGWRAVFLIAAALALLAAILLLLVV 173
|
|
| PRK09874 |
PRK09874 |
multidrug efflux MFS transporter MdtG; |
11-196 |
3.11e-04 |
|
multidrug efflux MFS transporter MdtG;
Pssm-ID: 182127 [Multi-domain] Cd Length: 408 Bit Score: 42.60 E-value: 3.11e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 11 LGMTIIIGTLFARFATSMSIPFLAIYLTTVKG-VS--AGMTGAIIGTSALVGVFASFIGGNLSDRFGRNMIIIWSMIAWV 87
Cdd:PRK09874 220 LVLSLFVTTLIIQVATGSIAPILTLYVRELAGnVSniAFISGMIASVPGVAALLSAPRLGKLGDRIGPEKILITALIFSV 299
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 88 FVFIGFSFANHVLSFFLLNALNGLCRSFFEPTSRALL--SDLTKPEYRLLVYNLRYGaiNVGVAIGPLVGLQIGSAKS-T 164
Cdd:PRK09874 300 LLLIPMSFVQTPLQLGILRFLLGAADGALLPAVQTLLvyNSSNQIAGRIFSYNQSFR--DIGNVTGPLMGAAISANYGfR 377
|
170 180 190
....*....|....*....|....*....|..
gi 1267255154 165 IPFLVAAGVyILYTAILAFQFKKYPIEKKKVN 196
Cdd:PRK09874 378 AVFLVTAGV-VLFNAVYSWNSLRRRRIPQVSN 408
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
13-181 |
4.13e-04 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 42.41 E-value: 4.13e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 13 MTIIIGTLFARFATSMSIPFLAIYLTTVKGVSAGMTGAIIGTSALVGVFASFIGGNLSDR-FGRNMIIIWSMIAWVFVFI 91
Cdd:cd06174 206 WLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRlIGRKPLLLIGLLLMALGLA 285
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 92 GFSFANHVLSFFLLNALNGLCRSFFEPTSRALLSDLTKPEYRLLVYNLRYGAINVGVAIGPLVG--LQIGSAKSTIPFLV 169
Cdd:cd06174 286 LLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAgfLLAATFGLTGAFLV 365
|
170
....*....|..
gi 1267255154 170 AAGVYILYTAIL 181
Cdd:cd06174 366 LAVLLLLAAILL 377
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
47-155 |
6.08e-04 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 41.57 E-value: 6.08e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 47 MTGAIIGTSALVG-VFASFIGGNLSDRFGRNMIIIWSMIAWVFVFIGFSFANHVLSFFLLNALNGLCRSFFEPTSRALLS 125
Cdd:TIGR00895 52 VQLGFLFSAGLIGmAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVS 131
|
90 100 110
....*....|....*....|....*....|
gi 1267255154 126 DLTKPEYRLLVYNLRYGAINVGVAIGPLVG 155
Cdd:TIGR00895 132 EYAPKRFRGTAVGLMFCGYPIGAAVGGFLA 161
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
13-364 |
6.12e-04 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 41.79 E-value: 6.12e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 13 MTIIIGTLFARFATSMSIPFLAiYLTTVKGVSAGMTGAIIGTSALVGVFASFIGGNLSDRFGRNMIIIWSMIAWVFVFIG 92
Cdd:cd17320 2 LLLALLVALGPLAIDMYLPALP-AIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 93 FSFANHVLSFFLLNALNGLCRSFFEPTSRALLSDLTKPEYRLLVYNLRYGAINVGVAIGPLVGLQIGSAKS-TIPFLVAA 171
Cdd:cd17320 81 CALASSIEQLLIARFLQGLGAAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGwRAIFVFLA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 172 GVYILYTAILAFQFKKYPIEKKKvnTEKPVTMLNAVRILRKDVVFLVALVGIILSNCGFShltttvSQYFANAHIFQDGV 251
Cdd:cd17320 161 LLGLLLLLLVLLFLPETLPEEKR--KPLLSSLLRAYKRVLKNRRFLGYALALGLSFAGLF------AYLAAAPFIYIEQL 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 252 ----TLFSYMLALNAIVVVVIQYPVIQICKKYTPLTSIMVG-TLFVSGGLFGFGIVESTLGAAVCTIIFTIGEVLMFSMT 326
Cdd:cd17320 233 glspAQFGLLFALNAIALILGSLLNGRLVRRFGPRRLLRLGlLLLLAAALVLLLAALLGGLSLWPLVAPLFLIFFGFGLI 312
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 1267255154 327 DVFIDDIAVS---HLKGTYFGAMGF------SGIGAVIGPWFGGVLL 364
Cdd:cd17320 313 FPNATSLALEpfpHVAGTASALLGFlqfligALAGALVGLLPNGTAL 359
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
24-382 |
9.13e-04 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 41.05 E-value: 9.13e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 24 FATSMSIPFLAIYLTTVKGVSAGMTGAIIGTSALVGVFASFIGGNLSDRFGRNMIIIWSMIAWVFVFIGFSFANHVLSFF 103
Cdd:cd17472 10 LGMFLVLPVLSVYAKSLPGATPTLIGLALGIYGLTQAIFQIPFGLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLI 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 104 LLNALNGLCRsfFEPTSRALLSDLTKPEYRLLVYNLRYGAIN----VGVAIGPLVGLQIGSAKStipFLVAAGVYILYTA 179
Cdd:cd17472 90 LGRALQGSGA--ISSVVMALLADLTREENRTKAMALIGASIGiafaISMVLGPLLAAHLGVSGL---FLITAILSLVSLL 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 180 ILAFqFKKYPiekKKVNTEKPVTMLNAVRILRKDVVFLVALVGIILS---NCGFSHLTTTVSQYFANAHifqdgvtlFSY 256
Cdd:cd17472 165 ILLF-FVPDP---PKIVQISEKEKKKLKKLLKNKRLLRLDFSIFILHfvlMAFFYILPLLLTQLGGGKG--------QLW 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 257 MLALNAIVV-VVIQYPVIQICKKYTPLTSIMVG--TLFVSGGLFGFGIVESTLGAAVCTIIFTIGEVLMFSMTDVFIDDI 333
Cdd:cd17472 233 KVYLPAILIgFILMVPFVIYAEKKGKMKQVFVSsiLLIAVGFLLLLFAATSLWLLIIGLIIFFIGFNLLEALLPSLVSKI 312
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 1267255154 334 AVSHLKGTYFGAMGFSG-IGAVIGPWFGGVLLDYYGYQNGFVVFSALAIF 382
Cdd:cd17472 313 APKEYRGTAMGIYNTSQfLGSFLGGALGGLLWGLLGYSSVFLTILILALL 362
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
32-183 |
1.36e-03 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 40.66 E-value: 1.36e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 32 FLAIYLTTVKGVSAGMTGAIIGTSALVGVFASFIGGNLSDRFGRNMIIIWSMIAWVF--VFIGFSFANHVLSFFLLNALN 109
Cdd:cd17316 199 FLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGIlaLPLFYLLSGSPTLLLLLLFIL 278
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1267255154 110 GLCRSFFEPTSRALLSDLTKPEYRLLVYNLRYGAINVGVAIGP-LVGLQIGSAKSTIPFLVAAGVYILYTAILAF 183
Cdd:cd17316 279 SFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPpLIALLLASTGGTGVPALILALLAIVALIVAL 353
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
50-136 |
1.72e-03 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 40.26 E-value: 1.72e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 50 AIIGTSALVGVFA-SFIGGNLSDRFGRNMIIIWSMIAWVFVFIGFSFANHVLSFFLLNALNGLCRSFFEPTSRALLSDLT 128
Cdd:cd17317 28 ALVQTIFFLGVLIgSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGIFTVGFVLGMEIV 107
|
....*...
gi 1267255154 129 KPEYRLLV 136
Cdd:cd17317 108 GPKYRSFV 115
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
30-388 |
1.90e-03 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 40.23 E-value: 1.90e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 30 IPFLAIYLttvkGVSAGMTGAIIGTSALVGVFASFIGGNLSDRFGRNMIIIWSMIAWVFVFIGFSFANHVLSFFLLNALN 109
Cdd:cd17478 19 LPLLIAKL----GLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALA 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 110 GLCRSFFEPTSRALLSDLTkPEYRLLVYNLRYGAINVGVAIGPLVGLQIGSAKSTIPFLVAAGVYILYTAILAFQFKKYP 189
Cdd:cd17478 95 GIGSAAFHPEGARLASQAA-GGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLIIPGLAVALLLLRLRPLK 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 190 IEKKKVNTEKPVTMLNAVRILRkdvVFLVALVGIILSNCGFSHLTTTVSQYFAnaHIFQDGVTlFSYMLALNAIVVVVIQ 269
Cdd:cd17478 174 KPEAKKAAAKSSARSTLKGVWR---ALLLLLIIVFLRSWVLSSLTTFLPFYLV--QRGYSLVF-AGLLLSLFLFAGAIGT 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 270 YPVIQICKKYTPLTSIMVGTLfvsGGLFGFGIVESTLGAAVCTIIFTIGEVLM--FSMTDVFIDDIAVSHLkGTYFG-AM 346
Cdd:cd17478 248 LIGGPLSDRFGRRRVIIASLL---LAAPFLLLFLLTPGIWSYILLVLAGFLLFasFPVTVVLAQELLPGNV-GLASGlMM 323
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 1267255154 347 GFSGIGAVIGPWFGGVLLDYYGYQNGFVVFSALAIFSTVAFP 388
Cdd:cd17478 324 GLSFGLGGIGAPVLGALADAFGLESVLLILALLPLLGALLAF 365
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
16-105 |
2.92e-03 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 39.46 E-value: 2.92e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 16 IIGTLFARFATSMSIPFLAIYLTTVKGVSAGMTGAIIGTSALVGVFASFIGGNLSDRFGRNMIIIWSMIAWVFVFIGFSF 95
Cdd:cd17321 174 VLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVGLLLLAL 253
|
90
....*....|
gi 1267255154 96 ANHVLSFFLL 105
Cdd:cd17321 254 LGADSSVWLL 263
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
254-387 |
6.41e-03 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 38.32 E-value: 6.41e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 254 FSYMLALNAIVVVVIQYPVIQICKKYTPLTSIMVGTLFVSGGLFGFGIVESTLGAAVCTIIFTIGEVLMFSMTDVFIDDI 333
Cdd:COG2223 42 LGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKW 121
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 1267255154 334 AVSHLKGTYFG-AMGFSGIGAVIGPWFGGVLLDYYGYQNGFVVFSALAIFSTVAF 387
Cdd:COG2223 122 FPPDRRGLALGlAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILGILLLVVAVLA 176
|
|
| MFS_SLC18B1 |
cd17385 |
Solute carrier family 18 member B1 of the Major Facilitator Superfamily of transporters; ... |
287-385 |
8.29e-03 |
|
Solute carrier family 18 member B1 of the Major Facilitator Superfamily of transporters; Solute carrier family 18 member B1 (SLC18B1) is the fourth member of the SLC18 transporter family, which includes vesicular monoamine transporters and vesicular acetylcholine transporter. It is predominantly expressed in the hippocampus and is associated with vesicles in astrocytes. It actively transports spermine and spermidine by exchange of H(+), and has been suggested to be a vesicular polyamine transporter (VPAT). SLC18B1 belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340943 [Multi-domain] Cd Length: 390 Bit Score: 37.97 E-value: 8.29e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267255154 287 VGTLFVSGG---LFGF-----------------GIVESTLGAAVCTIIFTIgevlmfsMTDVFIDDIAvshlkgTYFGAM 346
Cdd:cd17385 68 VAGMFVSGGctiLFGFldrvpdgtvfialcflvRIVEAVGFAAFITASFAI-------IAKEFPNNIA------TVLGTL 134
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 1267255154 347 G-FSGIGAVIGPWFGGVLLDYYGYQNGFVVFSALAIFSTV 385
Cdd:cd17385 135 EtFSGLGLMLGPPLGGFLYQAGGYELPFLVLGCLLLLTVP 174
|
|
| |
