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Conserved domains on  [gi|1267378129|ref|WP_098209187|]
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MULTISPECIES: helix-turn-helix transcriptional regulator [Bacillus cereus group]

Protein Classification

ArsR/SmtB family transcription factor( domain architecture ID 10001925)

ArsR (Arsenical Resistance Operon Repressor)/SmtB family transcription factor is a winged-helix-turn-helix transcriptional regulator that may be metal-sensing and modulate the expression of genes associated with metal homeostasis

Gene Ontology:  GO:0003700|GO:0006355|GO:0003677
PubMed:  10473770|28436329|12829264|28512703|30191942|15808743

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
2-87 8.10e-23

DNA-binding transcriptional regulator, ArsR family [Transcription];


:

Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 83.40  E-value: 8.10e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267378129  2 KEMYEEITEVLKVLAHPVRLSLVKiMLAKGPINVTTMYETLQMPQSTISQHLSKLKATKVVTGTRKGLEIYYEVTDKRTK 81
Cdd:COG0640    4 TKELEELAELFKALADPTRLRILR-LLAEGELCVGELAEALGLSQSTVSHHLKVLREAGLVTSRREGRWVYYRLADEALA 82


                 ....*.
gi 1267378129 82 SILACL 87
Cdd:COG0640   83 ELLEWL 88
 
Name Accession Description Interval E-value
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
2-87 8.10e-23

DNA-binding transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 83.40  E-value: 8.10e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267378129  2 KEMYEEITEVLKVLAHPVRLSLVKiMLAKGPINVTTMYETLQMPQSTISQHLSKLKATKVVTGTRKGLEIYYEVTDKRTK 81
Cdd:COG0640    4 TKELEELAELFKALADPTRLRILR-LLAEGELCVGELAEALGLSQSTVSHHLKVLREAGLVTSRREGRWVYYRLADEALA 82


                 ....*.
gi 1267378129 82 SILACL 87
Cdd:COG0640   83 ELLEWL 88
HTH_metalloreg NF033788
metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense ...
 10-84 8.81e-21

metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense toxic heavy metals such as arsenic or cadmium, and are released from DNA so that resistance factors will be expressed, include ArsR, SmtB, ZiaR, CadC, CadX, KmtR, etc. However, some members of this family, including the sporulation delaying system autorepressor SdpR and its family (see NF033789), may lack metal-binding cites and instead regulate other cellular processes.


Pssm-ID: 411368 [Multi-domain]  Cd Length: 76  Bit Score: 77.89  E-value: 8.81e-21
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1267378129 10 EVLKVLAHPVRLSLVKiMLAKGPINVTTMYETLQMPQSTISQHLSKLKATKVVTGTRKGLEIYYEVTDKRTKSIL 84
Cdd:NF033788   3 ELFKALADPTRLRILE-LLAEGELCVCELAEALGLSQSAVSQHLKVLRDAGLVTSRREGRWVYYRLADEHVAELL 76
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 12-80 5.69e-12

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 55.77  E-value: 5.69e-12
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1267378129 12 LKVLAHPVRLSLVKImLAKGPINVTTMYETLQMPQSTISQHLSKLKATKVVTGTRKGLEIYYEVTDKRT 80
Cdd:cd00090    1 LKALSDPTRLRILRL-LLEGPLTVSELAERLGLSQSTVSRHLKKLEEAGLVESRREGRRVYYSLTDAER 68
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
27-85 3.01e-10

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 51.06  E-value: 3.01e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1267378129  27 MLAKGPINVTTMYETLQMPQSTISQHLSKLKATKVVTGTRKGLEIYYEVTDKRTKSILA 85
Cdd:smart00418  5 LLAEGELCVCELAEILGLSQSTVSHHLKKLREAGLVESRREGKRVYYSLTDEKVADLLE 63
HTH_20 pfam12840
Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in ...
 10-68 6.31e-10

Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in transcriptional regulatory proteins.


Pssm-ID: 432824 [Multi-domain]  Cd Length: 61  Bit Score: 49.85  E-value: 6.31e-10
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 1267378129 10 EVLKVLAHPVRLSLVKIMLAKGPINVTTMYETLQMPQSTISQHLSKLKATKVVTGTRKG 68
Cdd:pfam12840  2 DVAEALADPTRLRILRALVGDEPLTASELARRLDISRNTLSYHLRKLEEAGLVEVVREG 60
repress_SdpR NF033789
autorepressor SdpR family transcription factor; Transcription factors in the family of the ...
 11-74 3.68e-09

autorepressor SdpR family transcription factor; Transcription factors in the family of the sporulation delaying system autorepressor SdpR (of Bacillus subtilis) resemble metalloregulatory transcriptional repressors such as ArsR, SmtB, CadX, ZiaR, etc., but may lack the key metal-binding residues.


Pssm-ID: 411369 [Multi-domain]  Cd Length: 79  Bit Score: 48.56  E-value: 3.68e-09
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1267378129 11 VLKVLAHPVRLSLVKiMLAKGPINVTTMYETLQMPQSTISQHLSKLKATKVVTGTRKGLEIYYE 74
Cdd:NF033789   1 TFKALSDPTRREILE-LLKEGDMTAGEIAEHFDMSKPSISHHLNILKQADLVTDERKGQFIYYS 63
 
Name Accession Description Interval E-value
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
2-87 8.10e-23

DNA-binding transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 83.40  E-value: 8.10e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267378129  2 KEMYEEITEVLKVLAHPVRLSLVKiMLAKGPINVTTMYETLQMPQSTISQHLSKLKATKVVTGTRKGLEIYYEVTDKRTK 81
Cdd:COG0640    4 TKELEELAELFKALADPTRLRILR-LLAEGELCVGELAEALGLSQSTVSHHLKVLREAGLVTSRREGRWVYYRLADEALA 82


                 ....*.
gi 1267378129 82 SILACL 87
Cdd:COG0640   83 ELLEWL 88
HTH_metalloreg NF033788
metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense ...
 10-84 8.81e-21

metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense toxic heavy metals such as arsenic or cadmium, and are released from DNA so that resistance factors will be expressed, include ArsR, SmtB, ZiaR, CadC, CadX, KmtR, etc. However, some members of this family, including the sporulation delaying system autorepressor SdpR and its family (see NF033789), may lack metal-binding cites and instead regulate other cellular processes.


Pssm-ID: 411368 [Multi-domain]  Cd Length: 76  Bit Score: 77.89  E-value: 8.81e-21
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1267378129 10 EVLKVLAHPVRLSLVKiMLAKGPINVTTMYETLQMPQSTISQHLSKLKATKVVTGTRKGLEIYYEVTDKRTKSIL 84
Cdd:NF033788   3 ELFKALADPTRLRILE-LLAEGELCVCELAEALGLSQSAVSQHLKVLRDAGLVTSRREGRWVYYRLADEHVAELL 76
COG4189 COG4189
Predicted transcriptional regulator, ArsR family [Transcription];
6-78 2.98e-12

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 443343 [Multi-domain]  Cd Length: 97  Bit Score: 56.89  E-value: 2.98e-12
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1267378129  6 EEITEVLKVLAHPVRLSLVKImLAKGPINVTTMYETLQMPQSTISQHLSKLKATKVVTGT----RKGLE-IYYEVTDK 78
Cdd:COG4189    7 EESLEVLKALASETRLRILRL-LAEEPLNVNELAEALGLPKSTVSYHIRKLEEAGLIRTEykpgKRGRQkICYLRVDK 83
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 12-80 5.69e-12

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 55.77  E-value: 5.69e-12
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1267378129 12 LKVLAHPVRLSLVKImLAKGPINVTTMYETLQMPQSTISQHLSKLKATKVVTGTRKGLEIYYEVTDKRT 80
Cdd:cd00090    1 LKALSDPTRLRILRL-LLEGPLTVSELAERLGLSQSTVSRHLKKLEEAGLVESRREGRRVYYSLTDAER 68
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
27-85 3.01e-10

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 51.06  E-value: 3.01e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1267378129  27 MLAKGPINVTTMYETLQMPQSTISQHLSKLKATKVVTGTRKGLEIYYEVTDKRTKSILA 85
Cdd:smart00418  5 LLAEGELCVCELAEILGLSQSTVSHHLKKLREAGLVESRREGKRVYYSLTDEKVADLLE 63
HTH_20 pfam12840
Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in ...
 10-68 6.31e-10

Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in transcriptional regulatory proteins.


Pssm-ID: 432824 [Multi-domain]  Cd Length: 61  Bit Score: 49.85  E-value: 6.31e-10
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 1267378129 10 EVLKVLAHPVRLSLVKIMLAKGPINVTTMYETLQMPQSTISQHLSKLKATKVVTGTRKG 68
Cdd:pfam12840  2 DVAEALADPTRLRILRALVGDEPLTASELARRLDISRNTLSYHLRKLEEAGLVEVVREG 60
repress_SdpR NF033789
autorepressor SdpR family transcription factor; Transcription factors in the family of the ...
 11-74 3.68e-09

autorepressor SdpR family transcription factor; Transcription factors in the family of the sporulation delaying system autorepressor SdpR (of Bacillus subtilis) resemble metalloregulatory transcriptional repressors such as ArsR, SmtB, CadX, ZiaR, etc., but may lack the key metal-binding residues.


Pssm-ID: 411369 [Multi-domain]  Cd Length: 79  Bit Score: 48.56  E-value: 3.68e-09
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1267378129 11 VLKVLAHPVRLSLVKiMLAKGPINVTTMYETLQMPQSTISQHLSKLKATKVVTGTRKGLEIYYE 74
Cdd:NF033789   1 TFKALSDPTRREILE-LLKEGDMTAGEIAEHFDMSKPSISHHLNILKQADLVTDERKGQFIYYS 63
COG3398 COG3398
Predicted transcriptional regulator, contains two HTH domains [Transcription];
11-78 6.74e-06

Predicted transcriptional regulator, contains two HTH domains [Transcription];


Pssm-ID: 442625 [Multi-domain]  Cd Length: 159  Bit Score: 41.40  E-value: 6.74e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1267378129  11 VLKVLAHPVRLSLVKIMLAKGPINVTTMYETLQMPQSTISQHLSKLKATKVVTGTRKGLEIYYEVTDK 78
Cdd:COG3398    90 ILAYLRRETPRRILLYLLENPGATNKELAEELGISRSTVSWHLKRLEEDGLVERERDGRNVRYYLNPP 157
HTH_5 pfam01022
Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding ...
 17-57 6.48e-05

Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding 'helix-turn-helix' motif. This family includes other proteins which are not included in the Prosite definition.


Pssm-ID: 425993 [Multi-domain]  Cd Length: 45  Bit Score: 36.65  E-value: 6.48e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 1267378129 17 HPVRLSLVKiMLAKGPINVTTMYETLQMPQSTISQHLSKLK 57
Cdd:pfam01022  1 DPTRLKILK-LLAEGELCVCELAEELGLSQSTVSHHLKKLR 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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