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Conserved domains on  [gi|1267416347|ref|WP_098239722|]
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MULTISPECIES: TetR/AcrR family transcriptional regulator [Priestia]

Protein Classification

TetR/AcrR family transcriptional regulator( domain architecture ID 11442015)

TetR/AcrR family transcriptional regulator may control genes involved in one of a variety of processes including antibiotic production, osmotic stress response, efflux pump expression, and multidrug resistance

CATH:  1.10.10.60|1.10.357.10
Gene Ontology:  GO:0003700|GO:0003677|GO:0006355
PubMed:  23602932
SCOP:  4000333

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AcrR COG1309
DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];
4-168 1.12e-21

DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];


:

Pssm-ID: 440920 [Multi-domain]  Cd Length: 156  Bit Score: 86.49  E-value: 1.12e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267416347   4 RKGEQTKALILEKASKLFNSQGYRASSISDIMHETGLRKGGIYNHFENKEEIMLSAFSFSIDTMSHFFSEAMAGKQGcME 83
Cdd:COG1309     2 RRREATRERILDAALELFAEKGYEGTSVRDIAARAGVSKGTLYRHFGSKEELLLAVLERLLEELLAALEEALAAEDP-RE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267416347  84 RLLSIVSVFEGMAEKELFpGGCPIMNAAIEADDadpllqekVREAMDSLLGMVRNLVQEGIKKGEVKQGVDPDFVATVFI 163
Cdd:COG1309    81 RLRALLRAYLEFLAENPA-LARLLLAEAAELPE--------LRAALRALLRRLRALLAELLRAGGLLADVDPDALARALL 151


                  ....*
gi 1267416347 164 STLEG 168
Cdd:COG1309   152 ALLDG 156
 
Name Accession Description Interval E-value
AcrR COG1309
DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];
4-168 1.12e-21

DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];


Pssm-ID: 440920 [Multi-domain]  Cd Length: 156  Bit Score: 86.49  E-value: 1.12e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267416347   4 RKGEQTKALILEKASKLFNSQGYRASSISDIMHETGLRKGGIYNHFENKEEIMLSAFSFSIDTMSHFFSEAMAGKQGcME 83
Cdd:COG1309     2 RRREATRERILDAALELFAEKGYEGTSVRDIAARAGVSKGTLYRHFGSKEELLLAVLERLLEELLAALEEALAAEDP-RE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267416347  84 RLLSIVSVFEGMAEKELFpGGCPIMNAAIEADDadpllqekVREAMDSLLGMVRNLVQEGIKKGEVKQGVDPDFVATVFI 163
Cdd:COG1309    81 RLRALLRAYLEFLAENPA-LARLLLAEAAELPE--------LRAALRALLRRLRALLAELLRAGGLLADVDPDALARALL 151


                  ....*
gi 1267416347 164 STLEG 168
Cdd:COG1309   152 ALLDG 156
ScbR_bind_reg NF041196
ScbR family autoregulator-binding transcription factor;
7-173 2.53e-18

ScbR family autoregulator-binding transcription factor;


Pssm-ID: 469100 [Multi-domain]  Cd Length: 191  Bit Score: 78.41  E-value: 2.53e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267416347   7 EQTKALILEKASKLFNSQGYRASSISDIMHETGLRKGGIYNHFENKEE----IMLSAFSFsidtmSHFFSEAMAGKQGC- 81
Cdd:NF041196    5 IRTRRAILEAAAEVFDERGYAAATISDILERAGVTKGALYFHFSSKEAlaraVLEEQVAR-----LREAVEPQRAGGGSk 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267416347  82 MERLLSIVSVfegMAekELFPGGcPIMNA----AIEADDADPLLQEKVREAMDsllgMVRNLVQEGIKKGEVKQGVDPDF 157
Cdd:NF041196   80 LQELVDLTHV---LA--RRLRTD-PVVRAgvrlSIEQAAIGAGLPTPYREWID----LVAELLAEARAAGELLPGVDPEE 149

                         170
                  ....*....|....*.
gi 1267416347 158 VATVFISTLEGALALS 173
Cdd:NF041196  150 AARLLVGAFTGVQMLS 165
TetR_N pfam00440
Bacterial regulatory proteins, tetR family;
13-59 2.25e-08

Bacterial regulatory proteins, tetR family;


Pssm-ID: 425684 [Multi-domain]  Cd Length: 47  Bit Score: 48.56  E-value: 2.25e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1267416347  13 ILEKASKLFNSQGYRASSISDIMHETGLRKGGIYNHFENKEEIMLSA 59
Cdd:pfam00440   1 ILDAARELFAERGYDATTVREIAKRAGVSKGALYRYFGSKEELLEAL 47
PRK10668 PRK10668
DNA-binding transcriptional repressor AcrR; Provisional
 4-55 4.47e-07

DNA-binding transcriptional repressor AcrR; Provisional


Pssm-ID: 182632 [Multi-domain]  Cd Length: 215  Bit Score: 48.46  E-value: 4.47e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1267416347   4 RKGEQTKALILEKASKLFNSQGYRASSISDIMHETGLRKGGIYNHFENKEEI 55
Cdd:PRK10668    7 QQAQETRQHILDAALRLFSQQGVSATSLADIAKAAGVTRGAIYWHFKNKSDL 58
DHAK_reg TIGR02366
probable dihydroxyacetone kinase regulator; The seed alignment for this family was built from ...
 9-56 8.44e-06

probable dihydroxyacetone kinase regulator; The seed alignment for this family was built from a set of closely related uncharacterized proteins associated with operons for the type of bacterial dihydroxyacetone kinase that transfers PEP-derived phosphate from a phosphoprotein, as in phosphotransferase system transport, rather than from ATP. Members have a TetR transcriptional regulator domain (pfam00440) at the N-terminus and sequence homology throughout.


Pssm-ID: 274100 [Multi-domain]  Cd Length: 176  Bit Score: 44.37  E-value: 8.44e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1267416347   9 TKALILEKASKLFNSQGYRASSISDIMHETGLRKGGIYNHFENKEEIM 56
Cdd:TIGR02366   4 TKKKIAKAFKDLMEVQAFHKISVSDIMQTAQIRRQTFYNHFQDKYELL 51
 
Name Accession Description Interval E-value
AcrR COG1309
DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];
4-168 1.12e-21

DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];


Pssm-ID: 440920 [Multi-domain]  Cd Length: 156  Bit Score: 86.49  E-value: 1.12e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267416347   4 RKGEQTKALILEKASKLFNSQGYRASSISDIMHETGLRKGGIYNHFENKEEIMLSAFSFSIDTMSHFFSEAMAGKQGcME 83
Cdd:COG1309     2 RRREATRERILDAALELFAEKGYEGTSVRDIAARAGVSKGTLYRHFGSKEELLLAVLERLLEELLAALEEALAAEDP-RE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267416347  84 RLLSIVSVFEGMAEKELFpGGCPIMNAAIEADDadpllqekVREAMDSLLGMVRNLVQEGIKKGEVKQGVDPDFVATVFI 163
Cdd:COG1309    81 RLRALLRAYLEFLAENPA-LARLLLAEAAELPE--------LRAALRALLRRLRALLAELLRAGGLLADVDPDALARALL 151


                  ....*
gi 1267416347 164 STLEG 168
Cdd:COG1309   152 ALLDG 156
ScbR_bind_reg NF041196
ScbR family autoregulator-binding transcription factor;
7-173 2.53e-18

ScbR family autoregulator-binding transcription factor;


Pssm-ID: 469100 [Multi-domain]  Cd Length: 191  Bit Score: 78.41  E-value: 2.53e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267416347   7 EQTKALILEKASKLFNSQGYRASSISDIMHETGLRKGGIYNHFENKEE----IMLSAFSFsidtmSHFFSEAMAGKQGC- 81
Cdd:NF041196    5 IRTRRAILEAAAEVFDERGYAAATISDILERAGVTKGALYFHFSSKEAlaraVLEEQVAR-----LREAVEPQRAGGGSk 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267416347  82 MERLLSIVSVfegMAekELFPGGcPIMNA----AIEADDADPLLQEKVREAMDsllgMVRNLVQEGIKKGEVKQGVDPDF 157
Cdd:NF041196   80 LQELVDLTHV---LA--RRLRTD-PVVRAgvrlSIEQAAIGAGLPTPYREWID----LVAELLAEARAAGELLPGVDPEE 149

                         170
                  ....*....|....*.
gi 1267416347 158 VATVFISTLEGALALS 173
Cdd:NF041196  150 AARLLVGAFTGVQMLS 165
TetR_N pfam00440
Bacterial regulatory proteins, tetR family;
13-59 2.25e-08

Bacterial regulatory proteins, tetR family;


Pssm-ID: 425684 [Multi-domain]  Cd Length: 47  Bit Score: 48.56  E-value: 2.25e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1267416347  13 ILEKASKLFNSQGYRASSISDIMHETGLRKGGIYNHFENKEEIMLSA 59
Cdd:pfam00440   1 ILDAARELFAERGYDATTVREIAKRAGVSKGALYRYFGSKEELLEAL 47
PRK10668 PRK10668
DNA-binding transcriptional repressor AcrR; Provisional
 4-55 4.47e-07

DNA-binding transcriptional repressor AcrR; Provisional


Pssm-ID: 182632 [Multi-domain]  Cd Length: 215  Bit Score: 48.46  E-value: 4.47e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1267416347   4 RKGEQTKALILEKASKLFNSQGYRASSISDIMHETGLRKGGIYNHFENKEEI 55
Cdd:PRK10668    7 QQAQETRQHILDAALRLFSQQGVSATSLADIAKAAGVTRGAIYWHFKNKSDL 58
DHAK_reg TIGR02366
probable dihydroxyacetone kinase regulator; The seed alignment for this family was built from ...
 9-56 8.44e-06

probable dihydroxyacetone kinase regulator; The seed alignment for this family was built from a set of closely related uncharacterized proteins associated with operons for the type of bacterial dihydroxyacetone kinase that transfers PEP-derived phosphate from a phosphoprotein, as in phosphotransferase system transport, rather than from ATP. Members have a TetR transcriptional regulator domain (pfam00440) at the N-terminus and sequence homology throughout.


Pssm-ID: 274100 [Multi-domain]  Cd Length: 176  Bit Score: 44.37  E-value: 8.44e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1267416347   9 TKALILEKASKLFNSQGYRASSISDIMHETGLRKGGIYNHFENKEEIM 56
Cdd:TIGR02366   4 TKKKIAKAFKDLMEVQAFHKISVSDIMQTAQIRRQTFYNHFQDKYELL 51
YbjK COG3226
DNA-binding transcriptional regulator YbjK [Transcription];
4-170 1.98e-05

DNA-binding transcriptional regulator YbjK [Transcription];


Pssm-ID: 442459 [Multi-domain]  Cd Length: 191  Bit Score: 43.39  E-value: 1.98e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267416347   4 RKGEQTKALILEKASKLFNSQGYRASSISDIMHETGLRKGGIYNHFENKEEIMLSAFSFSIDTMSHFFSEAMAGKQGCME 83
Cdd:COG3226     4 RRGEERRERILEAALRVIARDGVRGVTHRAVAAEAGVPLGSTTYYFRTRDELLAAAFERLAEREAARLRALLAAADDLED 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267416347  84 RLLSIVSVFEGM---------AEKELFpggcpiMNAAieaddADPLLQEKVREAMDSLLGMVRNLVQEGikkgevkQGVD 154
Cdd:COG3226    84 AAEALADLLAELlpadrdrllARYELY------LEAL-----RDPELRALLRRWRDRLREALARLLAAL-------GSPD 145

                         170
                  ....*....|....*.
gi 1267416347 155 PDFVATVFISTLEGAL 170
Cdd:COG3226   146 PPETARALVALIDGLT 161
TetR_C_13 pfam16925
Tetracyclin repressor-like, C-terminal domain; This domain is found in TetR-type regulators ...
 82-194 3.18e-04

Tetracyclin repressor-like, C-terminal domain; This domain is found in TetR-type regulators such as AcuR, acrylate-responsive repressor of acuR-acuI-dddL operons involved in acrylate catabolism.


Pssm-ID: 435659  Cd Length: 113  Bit Score: 38.81  E-value: 3.18e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267416347  82 MERLLSIV-SVFEGMaEKELFPGGCPIMNAAIEAddadPLLQEKVREAMDSLLGMVRNLV----QEGIKKGEVKQGVDPD 156
Cdd:pfam16925   3 LQRLRAFVaDAKAGM-ERYGYRRGCLVGNLGQEL----GDLPEGFRQRLESVLTDWQARVaaclREAQAAGEIAPDADCE 77

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1267416347 157 FVATVFISTLEGALALSKLYknqeymkRAVHHLRLFLD 194
Cdd:pfam16925  78 RLAEFFWIGWEGAVLRAKLE-------RSPQPLRLFID 108
TetR_C_17 pfam17922
Tetracyclin repressor-like, C-terminal domain; TetR family regulators are involved in the ...
 116-180 6.36e-03

Tetracyclin repressor-like, C-terminal domain; TetR family regulators are involved in the transcriptional control of multidrug efflux pumps, pathways for the biosynthesis of antibiotics, response to osmotic stress and toxic chemicals, control of catabolic pathways, differentiation processes, and pathogenicity. The TetR proteins identified in overm ultiple genera of bacteria and archaea share a common helix-turn-helix (HTH) structure in their DNA-binding domain. However, TetR proteins can work in different ways: they can bind a target operator directly to exert their effect (e.g. TetR binds Tet(A) gene to repress it in the absence of tetracycline), or they can be involved in complex regulatory cascades in which the TetR protein can either be modulated by another regulator or TetR can trigger the cellular response. This entry represents the C-terminal domain present in Yfir transcription regulator proteins found in Bacillus subtilus. TetR regulates the expression of the membrane-associated tetracycline resistance protein, TetA, which exports the tetracycline antibiotic out of the cell before it can attach to the ribosomes and inhibit protein synthesis. TetR blocks transcription from the genes encoding both TetA and TetR in the absence of antibiotic. The C-terminal domain is multi-helical and is interlocked in the homodimer with the helix-turn-helix (HTH) DNA-binding domain.


Pssm-ID: 436144  Cd Length: 100  Bit Score: 34.95  E-value: 6.36e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1267416347 116 DADPLLQEKVREAMDSLLGmvrnLVQEGIKKGEVKQGVDPDFVATVFISTLEGaLALSKLYKNQE 180
Cdd:pfam17922  36 ERRAYLQNRYERAVKVFKA----FLQKGVDRGEFKPVLPLESIARFFISFIDG-LILNALVLGPE 95
PRK09975 PRK09975
DNA-binding transcriptional regulator EnvR; Provisional
 8-55 7.11e-03

DNA-binding transcriptional regulator EnvR; Provisional


Pssm-ID: 182177 [Multi-domain]  Cd Length: 213  Bit Score: 36.25  E-value: 7.11e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1267416347   8 QTKALILEKASKLFNSQGYRASSISDIMHETGLRKGGIYNHFENKEEI 55
Cdd:PRK09975   11 KTRQELIETAIAQFALRGVSNTTLNDIADAANVTRGAIYWHFENKTQL 58
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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