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Conserved domains on  [gi|1267444785|ref|WP_098266238|]
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MULTISPECIES: HAMP domain-containing histidine kinase [Bacillus cereus group]

Protein Classification

HAMP domain-containing histidine kinase( domain architecture ID 12788129)

HAMP domain-containing histidine kinase is part of a two-component regulatory system and functions as a protein kinase that phosphorylates a target protein in response to a signal

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HATPase_BceS-YxdK-YvcQ-like cd16948
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 233-345 1.37e-57

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.


:

Pssm-ID: 340424 [Multi-domain]  Cd Length: 109  Bit Score: 182.49  E-value: 1.37e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267444785 233 SDRKWLSIAIGQIVVNAIKYTKiseaEKKEIQFQIEEKDQKVLLHIRDNGIGIPEQDVKRIFDPFFTGVNGRKTREATGM 312
Cdd:cd16948     1 TDAKWLSFIIGQIVSNALKYSK----QGGKIEIYSETNEQGVVLSIKDFGIGIPEEDLPRVFDKGFTGENGRNFQESTGM 76

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1267444785 313 GLYITKEICDNLHHGIYVQSAEGEGTTFTFQFA 345
Cdd:cd16948    77 GLYLVKKLCDKLGHKIDVESEVGEGTTFTITFP 109
BaeS COG0642
Signal transduction histidine kinase [Signal transduction mechanisms];
23-344 5.07e-50

Signal transduction histidine kinase [Signal transduction mechanisms];


:

Pssm-ID: 440407 [Multi-domain]  Cd Length: 328  Bit Score: 170.47  E-value: 5.07e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267444785  23 LFGLVLQLQNLLEKRSIDWSTWLYGLLLGTVVFTVYLIYDYRKRSVFLKRIEKYVAGGNTLHDSLLIDTSYTSEQELIVE 102
Cdd:COG0642     8 LVLLLLLLLLLLLALLLLLLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLLLLLLLLL 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267444785 103 SFTLLRQQYMNEVHKQHTKEQQQMIFMNQWIHQMKTPVSVIELVLQKFGKEHR-EARETVESIREENNRILNGLDLALHM 181
Cdd:COG0642    88 LLLLLLLLLLALLLLLEEANEAKSRFLANVSHELRTPLTAIRGYLELLLEELDeEQREYLETILRSADRLLRLINDLLDL 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267444785 182 ARLEQFAKDYKVEVVNVIDVIRGIINENRKSFIQSSVFPKVMFEEDTCMVASDRKWLSIAIGQIVVNAIKYTkiseAEKK 261
Cdd:COG0642   168 SRLEAGKLELEPEPVDLAELLEEVVELFRPLAEEKGIELELDLPDDLPTVRGDPDRLRQVLLNLLSNAIKYT----PEGG 243

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267444785 262 EIQFQIEEKDQKVLLHIRDNGIGIPEQDVKRIFDPFFTGVNGRKTrEATGMGLYITKEICDNLHHGIYVQSAEGEGTTFT 341
Cdd:COG0642   244 TVTVSVRREGDRVRISVEDTGPGIPPEDLERIFEPFFRTDPSRRG-GGTGLGLAIVKRIVELHGGTIEVESEPGKGTTFT 322


                  ...
gi 1267444785 342 FQF 344
Cdd:COG0642   323 VTL 325
 
Name Accession Description Interval E-value
HATPase_BceS-YxdK-YvcQ-like cd16948
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 233-345 1.37e-57

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.


Pssm-ID: 340424 [Multi-domain]  Cd Length: 109  Bit Score: 182.49  E-value: 1.37e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267444785 233 SDRKWLSIAIGQIVVNAIKYTKiseaEKKEIQFQIEEKDQKVLLHIRDNGIGIPEQDVKRIFDPFFTGVNGRKTREATGM 312
Cdd:cd16948     1 TDAKWLSFIIGQIVSNALKYSK----QGGKIEIYSETNEQGVVLSIKDFGIGIPEEDLPRVFDKGFTGENGRNFQESTGM 76

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1267444785 313 GLYITKEICDNLHHGIYVQSAEGEGTTFTFQFA 345
Cdd:cd16948    77 GLYLVKKLCDKLGHKIDVESEVGEGTTFTITFP 109
BaeS COG0642
Signal transduction histidine kinase [Signal transduction mechanisms];
23-344 5.07e-50

Signal transduction histidine kinase [Signal transduction mechanisms];


Pssm-ID: 440407 [Multi-domain]  Cd Length: 328  Bit Score: 170.47  E-value: 5.07e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267444785  23 LFGLVLQLQNLLEKRSIDWSTWLYGLLLGTVVFTVYLIYDYRKRSVFLKRIEKYVAGGNTLHDSLLIDTSYTSEQELIVE 102
Cdd:COG0642     8 LVLLLLLLLLLLLALLLLLLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLLLLLLLLL 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267444785 103 SFTLLRQQYMNEVHKQHTKEQQQMIFMNQWIHQMKTPVSVIELVLQKFGKEHR-EARETVESIREENNRILNGLDLALHM 181
Cdd:COG0642    88 LLLLLLLLLLALLLLLEEANEAKSRFLANVSHELRTPLTAIRGYLELLLEELDeEQREYLETILRSADRLLRLINDLLDL 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267444785 182 ARLEQFAKDYKVEVVNVIDVIRGIINENRKSFIQSSVFPKVMFEEDTCMVASDRKWLSIAIGQIVVNAIKYTkiseAEKK 261
Cdd:COG0642   168 SRLEAGKLELEPEPVDLAELLEEVVELFRPLAEEKGIELELDLPDDLPTVRGDPDRLRQVLLNLLSNAIKYT----PEGG 243

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267444785 262 EIQFQIEEKDQKVLLHIRDNGIGIPEQDVKRIFDPFFTGVNGRKTrEATGMGLYITKEICDNLHHGIYVQSAEGEGTTFT 341
Cdd:COG0642   244 TVTVSVRREGDRVRISVEDTGPGIPPEDLERIFEPFFRTDPSRRG-GGTGLGLAIVKRIVELHGGTIEVESEPGKGTTFT 322


                  ...
gi 1267444785 342 FQF 344
Cdd:COG0642   323 VTL 325
NtrY COG5000
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ...
 134-349 8.11e-29

Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];


Pssm-ID: 444024 [Multi-domain]  Cd Length: 422  Bit Score: 115.44  E-value: 8.11e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267444785 134 HQMKTPVSVI----ELVLQKFGKEHREARETVESIREennRILNGLDlalhmaRLEQFAKDY---------KVEVVNVID 200
Cdd:COG5000   210 HEIKNPLTPIqlsaERLRRKLADKLEEDREDLERALD---TIIRQVD------RLKRIVDEFldfarlpepQLEPVDLNE 280

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267444785 201 VIRGIINENRKSFIQSSVFPKVMFEEDTCMVASDRKWLSIAIGQIVVNAIkytkisEA--EKKEIQFQIEEKDQKVLLHI 278
Cdd:COG5000   281 LLREVLALYEPALKEKDIRLELDLDPDLPEVLADRDQLEQVLINLLKNAI------EAieEGGEIEVSTRREDGRVRIEV 354

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1267444785 279 RDNGIGIPEQDVKRIFDPFFTgvngrkTREA-TGMGLYITKEICDNlHHG-IYVQSAEGEGTTFTFQFAKDEE 349
Cdd:COG5000   355 SDNGPGIPEEVLERIFEPFFT------TKPKgTGLGLAIVKKIVEE-HGGtIELESRPGGGTTFTIRLPLAEE 420
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 234-344 1.75e-28

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 106.96  E-value: 1.75e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267444785  234 DRKWLSIAIGQIVVNAIKYTKiseaEKKEIQFQIEEKDQKVLLHIRDNGIGIPEQDVKRIFDPFFTGVNGRKTREATGMG 313
Cdd:smart00387   2 DPDRLRQVLSNLLDNAIKYTP----EGGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDKRSRKIGGTGLG 77

                           90       100       110
                   ....*....|....*....|....*....|.
gi 1267444785  314 LYITKEICDNLHHGIYVQSAEGEGTTFTFQF 344
Cdd:smart00387  78 LSIVKKLVELHGGEISVESEPGGGTTFTITL 108
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 234-344 1.78e-23

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 93.59  E-value: 1.78e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267444785 234 DRKWLSIAIGQIVVNAIKYTkiseAEKKEIQFQIEEKDQkVLLHIRDNGIGIPEQDVKRIFDPFFTGvnGRKTREATGMG 313
Cdd:pfam02518   2 DELRLRQVLSNLLDNALKHA----AKAGEITVTLSEGGE-LTLTVEDNGIGIPPEDLPRIFEPFSTA--DKRGGGGTGLG 74

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1267444785 314 LYITKEICDNLHHGIYVQSAEGEGTTFTFQF 344
Cdd:pfam02518  75 LSIVRKLVELLGGTITVESEPGGGTTVTLTL 105
PRK11100 PRK11100
sensory histidine kinase CreC; Provisional
 134-345 2.96e-19

sensory histidine kinase CreC; Provisional


Pssm-ID: 236846 [Multi-domain]  Cd Length: 475  Bit Score: 88.75  E-value: 2.96e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267444785 134 HQMKTPVSVI----ELvLQKfGKEHREARETVESIREENNRILNGLDLALHMARLEQFAKDYKVEVVNVIDVIRGIINEN 209
Cdd:PRK11100  265 HELKSPLAAIrgaaEL-LQE-DPPPEDRARFTGNILTQSARLQQLIDRLLELARLEQRQELEVLEPVALAALLEELVEAR 342

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267444785 210 RKSFIQSSVfpKVMFEEDTCMVASDRKWLSIAIGQIVVNAIKYTkiseAEKKEIQFQIEEKDQKVLLHIRDNGIGIPEQD 289
Cdd:PRK11100  343 EAQAAAKGI--TLRLRPDDARVLGDPFLLRQALGNLLDNAIDFS----PEGGTITLSAEVDGEQVALSVEDQGPGIPDYA 416

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1267444785 290 VKRIFDPFFT---GVNGRKTreaTGMGLYITKEICDnLHHG-IYVQSAEGEGT--TFTFQFA 345
Cdd:PRK11100  417 LPRIFERFYSlprPANGRKS---TGLGLAFVREVAR-LHGGeVTLRNRPEGGVlaTLTLPRH 474
T2SS_HK NF038348
histidine kinase;
278-341 2.52e-09

histidine kinase;


Pssm-ID: 439642 [Multi-domain]  Cd Length: 574  Bit Score: 58.42  E-value: 2.52e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1267444785 278 IRDNGIGIPEQDVKRIFDPFFTgvnGRKTREATGMGLYITKEICDnlHHG--IYVQSAEGEGTTFT 341
Cdd:NF038348  508 ISDTGKGIPPDVMGRIFDPFFT---TKPVGQGTGLGLSISHGIVE--HHRgrIDVASEPGRGSTFT 568
nifL_nitrog TIGR02938
nitrogen fixation negative regulator NifL; NifL is a modulator of the nitrogen fixation ...
 242-344 8.36e-08

nitrogen fixation negative regulator NifL; NifL is a modulator of the nitrogen fixation positive regulator protein NifA, and is therefore a negative regulator. It binds NifA. NifA and NifL are encoded by adjacent genes. [Central intermediary metabolism, Nitrogen fixation, Regulatory functions, Protein interactions]


Pssm-ID: 131984 [Multi-domain]  Cd Length: 494  Bit Score: 53.75  E-value: 8.36e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267444785 242 IGQIVVNAIKYTKISEAEKKEIQFQIEEKDQKVLLHIRDNGIGIPEQDVKRIFDPFFTGVNGrkTREATGMGLYITKEIC 321
Cdd:TIGR02938 392 FKALVDNAIEAMNIKGWKRRELSITTALNGDLIVVSILDSGPGIPQDLRYKVFEPFFTTKGG--SRKHIGMGLSVAQEIV 469

                          90       100
                  ....*....|....*....|....
gi 1267444785 322 dNLHHG-IYVQSAEGEGTTFTFQF 344
Cdd:TIGR02938 470 -ADHGGiIDLDDDYSEGCRIIVEF 492
PRK10490 PRK10490
sensor protein KdpD; Provisional
 96-342 1.21e-07

sensor protein KdpD; Provisional


Pssm-ID: 236701 [Multi-domain]  Cd Length: 895  Bit Score: 53.50  E-value: 1.21e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267444785  96 EQELIVESFTLLRQQYMNEVHKQHTKEQQQMIFMNQWI---------HQMKTPVSVI----ELVLQKFGKEHREARETVE 162
Cdd:PRK10490  626 EQQRLLETFTLLIANALERLTLTASEEQARLASEREQLrnallaalsHDLRTPLTVLfgqaEILTLDLASEGSPHARQAS 705

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267444785 163 SIREE---NNRILNGLdlaLHMARLEQFAKDYKVEVVNVIDVIRGIINENRKSFIQSSVfpKVMFEEDTCMVASDRKWLS 239
Cdd:PRK10490  706 EIRQQvlnTTRLVNNL---LDMARIQSGGFNLRKEWLTLEEVVGSALQMLEPGLSGHPI--NLSLPEPLTLIHVDGPLFE 780

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267444785 240 IAIGQIVVNAIKYTkiseAEKKEIQFQIEEKDQKVLLHIRDNGIGIPEQDVKRIFDPFftgvnGRKTREAT----GMGLY 315
Cdd:PRK10490  781 RVLINLLENAVKYA----GAQAEIGIDAHVEGERLQLDVWDNGPGIPPGQEQLIFDKF-----ARGNKESAipgvGLGLA 851

                         250       260
                  ....*....|....*....|....*...
gi 1267444785 316 ITKEICDnLHHG-IYVQSAEGEGTTFTF 342
Cdd:PRK10490  852 ICRAIVE-VHGGtIWAENRPEGGACFRV 878
HisKA smart00388
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ...
 128-186 4.17e-03

His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.


Pssm-ID: 214644 [Multi-domain]  Cd Length: 66  Bit Score: 35.23  E-value: 4.17e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1267444785  128 FMNQWIHQMKTPVSVIELVLQKFGKEHR--EARETVESIREENNRILNGLDLALHMARLEQ 186
Cdd:smart00388   5 FLANLSHELRTPLTAIRGYLELLLDTELseEQREYLETILREAERLLRLINDLLDLSRIEA 65
HisKA pfam00512
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ...
 134-186 4.51e-03

His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.


Pssm-ID: 459839 [Multi-domain]  Cd Length: 66  Bit Score: 35.26  E-value: 4.51e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1267444785 134 HQMKTPVSVIELVLQKFGKEHR--EARETVESIREENNRILNGLDLALHMARLEQ 186
Cdd:pfam00512  11 HELRTPLTAIRGYLELLRDEKLdeEQREYLETILRSAERLLRLINDLLDLSRIEA 65
 
Name Accession Description Interval E-value
HATPase_BceS-YxdK-YvcQ-like cd16948
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 233-345 1.37e-57

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.


Pssm-ID: 340424 [Multi-domain]  Cd Length: 109  Bit Score: 182.49  E-value: 1.37e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267444785 233 SDRKWLSIAIGQIVVNAIKYTKiseaEKKEIQFQIEEKDQKVLLHIRDNGIGIPEQDVKRIFDPFFTGVNGRKTREATGM 312
Cdd:cd16948     1 TDAKWLSFIIGQIVSNALKYSK----QGGKIEIYSETNEQGVVLSIKDFGIGIPEEDLPRVFDKGFTGENGRNFQESTGM 76

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1267444785 313 GLYITKEICDNLHHGIYVQSAEGEGTTFTFQFA 345
Cdd:cd16948    77 GLYLVKKLCDKLGHKIDVESEVGEGTTFTITFP 109
BaeS COG0642
Signal transduction histidine kinase [Signal transduction mechanisms];
23-344 5.07e-50

Signal transduction histidine kinase [Signal transduction mechanisms];


Pssm-ID: 440407 [Multi-domain]  Cd Length: 328  Bit Score: 170.47  E-value: 5.07e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267444785  23 LFGLVLQLQNLLEKRSIDWSTWLYGLLLGTVVFTVYLIYDYRKRSVFLKRIEKYVAGGNTLHDSLLIDTSYTSEQELIVE 102
Cdd:COG0642     8 LVLLLLLLLLLLLALLLLLLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLLLLLLLLL 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267444785 103 SFTLLRQQYMNEVHKQHTKEQQQMIFMNQWIHQMKTPVSVIELVLQKFGKEHR-EARETVESIREENNRILNGLDLALHM 181
Cdd:COG0642    88 LLLLLLLLLLALLLLLEEANEAKSRFLANVSHELRTPLTAIRGYLELLLEELDeEQREYLETILRSADRLLRLINDLLDL 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267444785 182 ARLEQFAKDYKVEVVNVIDVIRGIINENRKSFIQSSVFPKVMFEEDTCMVASDRKWLSIAIGQIVVNAIKYTkiseAEKK 261
Cdd:COG0642   168 SRLEAGKLELEPEPVDLAELLEEVVELFRPLAEEKGIELELDLPDDLPTVRGDPDRLRQVLLNLLSNAIKYT----PEGG 243

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267444785 262 EIQFQIEEKDQKVLLHIRDNGIGIPEQDVKRIFDPFFTGVNGRKTrEATGMGLYITKEICDNLHHGIYVQSAEGEGTTFT 341
Cdd:COG0642   244 TVTVSVRREGDRVRISVEDTGPGIPPEDLERIFEPFFRTDPSRRG-GGTGLGLAIVKRIVELHGGTIEVESEPGKGTTFT 322


                  ...
gi 1267444785 342 FQF 344
Cdd:COG0642   323 VTL 325
KdpD COG2205
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
114-349 1.51e-47

K+-sensing histidine kinase KdpD [Signal transduction mechanisms];


Pssm-ID: 441807 [Multi-domain]  Cd Length: 239  Bit Score: 161.23  E-value: 1.51e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267444785 114 EVHKQHTKEQQQMIFMNQWI----HQMKTPVSVI----ELVLQKFGKEHREARETVESIREENNRILNGLDLALHMARLE 185
Cdd:COG2205     1 ELEEALEELEELERLKSEFLanvsHELRTPLTSIlgaaELLLDEEDLSPEERRELLEIIRESAERLLRLIEDLLDLSRLE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267444785 186 QFAKDYKVEVVNVIDVIRGIINENRKSFIQSSVFPKVMFEEDTCMVASDRKWLSIAIGQIVVNAIKYTKiseaEKKEIQF 265
Cdd:COG2205    81 SGKLSLELEPVDLAELLEEAVEELRPLAEEKGIRLELDLPPELPLVYADPELLEQVLANLLDNAIKYSP----PGGTITI 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267444785 266 QIEEKDQKVLLHIRDNGIGIPEQDVKRIFDPFFTGVNGRKTReATGMGLYITKEICDnLHHG-IYVQSAEGEGTTFTFQF 344
Cdd:COG2205   157 SARREGDGVRISVSDNGPGIPEEELERIFERFYRGDNSRGEG-GTGLGLAIVKRIVE-AHGGtIWVESEPGGGTTFTVTL 234


                  ....*
gi 1267444785 345 AKDEE 349
Cdd:COG2205   235 PLAES 239
WalK COG5002
Sensor histidine kinase WalK [Signal transduction mechanisms];
5-349 1.77e-44

Sensor histidine kinase WalK [Signal transduction mechanisms];


Pssm-ID: 444026 [Multi-domain]  Cd Length: 390  Bit Score: 157.41  E-value: 1.77e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267444785   5 NYLIDRFSLLLSYIVSLCLFGLVLQLQNLLEKRSIDWSTWLYGLLLGTVVFTVYLIYDYRKRSVFLKRIEKYVAGGNTLH 84
Cdd:COG5002    45 LLLLLLLLALLLLLLLLLLLLLALLLLLLLLLLLLALALLLLALLLLLLLLLLLLALLILLLLLALLILLAALLLLLSEL 124

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267444785  85 DSLLIDTSYTSEQELIVESFTLLRQQYMNEVHKQHTKEQQQmifmNQWI----HQMKTPVSVI----ELVLQKFGKEHRE 156
Cdd:COG5002   125 LLLLLLLGRLSLRLSALLLGLLLLAAVERDITELERLEQMR----REFVanvsHELRTPLTSIrgylELLLDGAADDPEE 200

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267444785 157 ARETVESIREENNRiLNGL--DLaLHMARLEQFAKDYKVEVVNVIDVIRGIINENRKSFIQSSVFPKVMFEEDTCMVASD 234
Cdd:COG5002   201 RREYLEIILEEAER-LSRLvnDL-LDLSRLESGELKLEKEPVDLAELLEEVVEELRPLAEEKGIELELDLPEDPLLVLGD 278

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267444785 235 RKWLSIAIGQIVVNAIKYTKiseaEKKEIQFQIEEKDQKVLLHIRDNGIGIPEQDVKRIFDPFFTGVNGRkTREA--TGM 312
Cdd:COG5002   279 PDRLEQVLTNLLDNAIKYTP----EGGTITVSLREEDDQVRISVRDTGIGIPEEDLPRIFERFYRVDKSR-SRETggTGL 353

                         330       340       350
                  ....*....|....*....|....*....|....*...
gi 1267444785 313 GLYITKEICDnLHHG-IYVQSAEGEGTTFTFQFAKDEE 349
Cdd:COG5002   354 GLAIVKHIVE-AHGGrIWVESEPGKGTTFTITLPLARE 390
NtrY COG5000
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ...
 134-349 8.11e-29

Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];


Pssm-ID: 444024 [Multi-domain]  Cd Length: 422  Bit Score: 115.44  E-value: 8.11e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267444785 134 HQMKTPVSVI----ELVLQKFGKEHREARETVESIREennRILNGLDlalhmaRLEQFAKDY---------KVEVVNVID 200
Cdd:COG5000   210 HEIKNPLTPIqlsaERLRRKLADKLEEDREDLERALD---TIIRQVD------RLKRIVDEFldfarlpepQLEPVDLNE 280

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267444785 201 VIRGIINENRKSFIQSSVFPKVMFEEDTCMVASDRKWLSIAIGQIVVNAIkytkisEA--EKKEIQFQIEEKDQKVLLHI 278
Cdd:COG5000   281 LLREVLALYEPALKEKDIRLELDLDPDLPEVLADRDQLEQVLINLLKNAI------EAieEGGEIEVSTRREDGRVRIEV 354

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1267444785 279 RDNGIGIPEQDVKRIFDPFFTgvngrkTREA-TGMGLYITKEICDNlHHG-IYVQSAEGEGTTFTFQFAKDEE 349
Cdd:COG5000   355 SDNGPGIPEEVLERIFEPFFT------TKPKgTGLGLAIVKKIVEE-HGGtIELESRPGGGTTFTIRLPLAEE 420
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 234-344 1.75e-28

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 106.96  E-value: 1.75e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267444785  234 DRKWLSIAIGQIVVNAIKYTKiseaEKKEIQFQIEEKDQKVLLHIRDNGIGIPEQDVKRIFDPFFTGVNGRKTREATGMG 313
Cdd:smart00387   2 DPDRLRQVLSNLLDNAIKYTP----EGGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDKRSRKIGGTGLG 77

                           90       100       110
                   ....*....|....*....|....*....|.
gi 1267444785  314 LYITKEICDNLHHGIYVQSAEGEGTTFTFQF 344
Cdd:smart00387  78 LSIVKKLVELHGGEISVESEPGGGTTFTITL 108
HATPase cd00075
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ...
 238-344 2.04e-28

Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.


Pssm-ID: 340391 [Multi-domain]  Cd Length: 102  Bit Score: 106.53  E-value: 2.04e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267444785 238 LSIAIGQIVVNAIKYTKiseaEKKEIQFQIEEKDQKVLLHIRDNGIGIPEQDVKRIFDPFFTGVNGRkTREATGMGLYIT 317
Cdd:cd00075     1 LEQVLSNLLDNALKYSP----PGGTIEISLRQEGDGVVLEVEDNGPGIPEEDLERIFERFYRGDKSR-EGGGTGLGLAIV 75

                          90       100
                  ....*....|....*....|....*..
gi 1267444785 318 KEICDNLHHGIYVQSAEGEGTTFTFQF 344
Cdd:cd00075    76 RRIVEAHGGRITVESEPGGGTTFTVTL 102
COG4191 COG4191
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ...
 134-344 2.44e-27

Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];


Pssm-ID: 443345 [Multi-domain]  Cd Length: 361  Bit Score: 110.66  E-value: 2.44e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267444785 134 HQMKTPVSVI----ELVLQKFGKEHR--EARETVESIREENNRIlngldlALHMARLEQFAK--DYKVEVVNVIDVIRGI 205
Cdd:COG4191   151 HEINNPLAAIlgnaELLRRRLEDEPDpeELREALERILEGAERA------AEIVRSLRAFSRrdEEEREPVDLNELIDEA 224

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267444785 206 INENRKSFIQSSVFPKVMFEEDTCMVASDRkwlsIAIGQIVVN-------AIKytkisEAEKKEIQFQIEEKDQKVLLHI 278
Cdd:COG4191   225 LELLRPRLKARGIEVELDLPPDLPPVLGDP----GQLEQVLLNllinaidAME-----EGEGGRITISTRREGDYVVISV 295

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267444785 279 RDNGIGIPEQDVKRIFDPFFTgvngrkTREA---TGMGLYITKEICDNlHHG-IYVQSAEGEGTTFTFQF 344
Cdd:COG4191   296 RDNGPGIPPEVLERIFEPFFT------TKPVgkgTGLGLSISYGIVEK-HGGrIEVESEPGGGTTFTITL 358
COG4251 COG4251
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ...
 134-349 1.48e-25

Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];


Pssm-ID: 443393 [Multi-domain]  Cd Length: 503  Bit Score: 107.18  E-value: 1.48e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267444785 134 HQMKTPVSVIELVLQKFGKEHR-----EARETVESIREENNR---ILNGLdlaLHMARLEQfaKDYKVEVVNVIDVIRGI 205
Cdd:COG4251   291 HDLREPLRKISGFSQLLEEDYGdkldeEGREYLERIRDAAERmqaLIDDL---LAYSRVGR--QELEFEPVDLNELLEEV 365

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267444785 206 INENRKSFIQSSVfpKVMFEEDtCMVASDRKWLSIAIGQIVVNAIKYTKisEAEKKEIQFQIEEKDQKVLLHIRDNGIGI 285
Cdd:COG4251   366 LEDLEPRIEERGA--EIEVGPL-PTVRGDPTLLRQVFQNLISNAIKYSR--PGEPPRIEIGAEREGGEWVFSVRDNGIGI 440

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1267444785 286 PEQDVKRIFDPFFTgVNGRKTREATGMGLYITKEICDNlHHG-IYVQSAEGEGTTFTFQFAKDEE 349
Cdd:COG4251   441 DPEYAEKIFEIFQR-LHSRDEYEGTGIGLAIVKKIVER-HGGrIWVESEPGEGATFYFTLPKAPA 503
NtrB COG3852
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
134-341 1.66e-23

Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];


Pssm-ID: 443061 [Multi-domain]  Cd Length: 361  Bit Score: 99.92  E-value: 1.66e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267444785 134 HQMKTPVSVIELVLQKFGKE--HREARETVESIREENNRIlNGLdlalhMARLEQFAK--DYKVEVVNVIDVIRGIInen 209
Cdd:COG3852   144 HEIRNPLTGIRGAAQLLERElpDDELREYTQLIIEEADRL-NNL-----VDRLLSFSRprPPEREPVNLHEVLERVL--- 214

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267444785 210 rkSFIQSSVFPKVMFEED----TCMVASDRKWLSIAIGQIVVNAIkytkisEA--EKKEI--------QFQIEEKDQK-- 273
Cdd:COG3852   215 --ELLRAEAPKNIRIVRDydpsLPEVLGDPDQLIQVLLNLVRNAA------EAmpEGGTItirtrverQVTLGGLRPRly 286

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267444785 274 VLLHIRDNGIGIPEQDVKRIFDPFFTgvngrkTREA-TGMGLYITKEICDNlHHG-IYVQSAEGEGTTFT 341
Cdd:COG3852   287 VRIEVIDNGPGIPEEILDRIFEPFFT------TKEKgTGLGLAIVQKIVEQ-HGGtIEVESEPGKGTTFR 349
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 234-344 1.78e-23

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 93.59  E-value: 1.78e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267444785 234 DRKWLSIAIGQIVVNAIKYTkiseAEKKEIQFQIEEKDQkVLLHIRDNGIGIPEQDVKRIFDPFFTGvnGRKTREATGMG 313
Cdd:pfam02518   2 DELRLRQVLSNLLDNALKHA----AKAGEITVTLSEGGE-LTLTVEDNGIGIPPEDLPRIFEPFSTA--DKRGGGGTGLG 74

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1267444785 314 LYITKEICDNLHHGIYVQSAEGEGTTFTFQF 344
Cdd:pfam02518  75 LSIVRKLVELLGGTITVESEPGGGTTVTLTL 105
KinD COG5808
Sporulation sensor histidine kinase D [Cell cycle control, cell division, chromosome ...
 106-344 2.61e-21

Sporulation sensor histidine kinase D [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444510 [Multi-domain]  Cd Length: 454  Bit Score: 94.43  E-value: 2.61e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267444785 106 LLRQQYMNEVHKQHTKEQQQMI---FMNQWIHQMKTPVSVIE--LVLQKFGKEHREARETVESIREENNRILNGLDLALH 180
Cdd:COG5808   219 LLKRKTLLERVIQEINTQKLELigtFAASTAHEIRNPLTSIKgfIQLLQEKYPELEDQKYFDIIQEEIQRINQIVSEFLV 298

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267444785 181 MARLEqfakDYKVEVVNVIDVIRGIInenrkSFIQSSVFPK-----VMFEEDTCMVASDRKWLSIAIGQIVVNAIKYTKi 255
Cdd:COG5808   299 LGKPT----AKKLELDDLNELIEEIL-----SIIDSEANLKnirveKQSLDEPLHIKCDKDRIKQVLLNLIKNAIEAMK- 368

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267444785 256 seaEKKEIQFQIEEKDQKVLLHIRDNGIGIPEQDVKRIFDPFFTgvngrKTREATGMGLYITKEICDNLHHGIYVQSAEG 335
Cdd:COG5808   369 ---EGGKLTISIENDDEKAVIEVIDNGEGIPEDIIDEIFEPFVT-----TKEGGTGLGLSVCKRIVEMHGGEIDIESEEG 440


                  ....*....
gi 1267444785 336 EGTTFTFQF 344
Cdd:COG5808   441 KGTTFTIRL 449
PRK11100 PRK11100
sensory histidine kinase CreC; Provisional
 134-345 2.96e-19

sensory histidine kinase CreC; Provisional


Pssm-ID: 236846 [Multi-domain]  Cd Length: 475  Bit Score: 88.75  E-value: 2.96e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267444785 134 HQMKTPVSVI----ELvLQKfGKEHREARETVESIREENNRILNGLDLALHMARLEQFAKDYKVEVVNVIDVIRGIINEN 209
Cdd:PRK11100  265 HELKSPLAAIrgaaEL-LQE-DPPPEDRARFTGNILTQSARLQQLIDRLLELARLEQRQELEVLEPVALAALLEELVEAR 342

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267444785 210 RKSFIQSSVfpKVMFEEDTCMVASDRKWLSIAIGQIVVNAIKYTkiseAEKKEIQFQIEEKDQKVLLHIRDNGIGIPEQD 289
Cdd:PRK11100  343 EAQAAAKGI--TLRLRPDDARVLGDPFLLRQALGNLLDNAIDFS----PEGGTITLSAEVDGEQVALSVEDQGPGIPDYA 416

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1267444785 290 VKRIFDPFFT---GVNGRKTreaTGMGLYITKEICDnLHHG-IYVQSAEGEGT--TFTFQFA 345
Cdd:PRK11100  417 LPRIFERFYSlprPANGRKS---TGLGLAFVREVAR-LHGGeVTLRNRPEGGVlaTLTLPRH 474
HATPase_EvgS-ArcB-TorS-like cd16922
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ...
 242-342 8.24e-18

Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340399 [Multi-domain]  Cd Length: 110  Bit Score: 77.92  E-value: 8.24e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267444785 242 IGQIVV----NAIKYTkiseaEKKEIQFQI---EEKDQKVLLH--IRDNGIGIPEQDVKRIFDPFF-TGVNGRKTREATG 311
Cdd:cd16922     1 LRQILLnllgNAIKFT-----EEGEVTLRVsleEEEEDGVQLRfsVEDTGIGIPEEQQARLFEPFSqADSSTTRKYGGTG 75

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1267444785 312 MGLYITKEICdNLHHG-IYVQSAEGEGTTFTF 342
Cdd:cd16922    76 LGLAISKKLV-ELMGGdISVESEPGQGSTFTF 106
PRK11360 PRK11360
two-component system sensor histidine kinase AtoS;
134-349 8.26e-18

two-component system sensor histidine kinase AtoS;


Pssm-ID: 236901 [Multi-domain]  Cd Length: 607  Bit Score: 84.63  E-value: 8.26e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267444785 134 HQMKTPVSVIE-----LVLQKFGKEHREARETvesIREENNRILNGLDLALHMARLEQfakdYKVEVVNVIDVIRGIINE 208
Cdd:PRK11360  399 HEIRNPLTAIRgyvqiWRQQTSDPPSQEYLSV---VLREVDRLNKVIDQLLEFSRPRE----SQWQPVSLNALVEEVLQL 471

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267444785 209 NRKSFIQSSVFPKVMFEEDTCMVASDRKWLSIAIGQIVVNAIkytkisEAEKKEIQFQIE---EKDQKVLLHIRDNGIGI 285
Cdd:PRK11360  472 FQTAGVQARVDFETELDNELPPIWADPELLKQVLLNILINAV------QAISARGKIRIRtwqYSDGQVAVSIEDNGCGI 545

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1267444785 286 PEQDVKRIFDPFFTgvngrkTREA-TGMGLYITKEICdNLHHG-IYVQSAEGEGTTFTFQFAKDEE 349
Cdd:PRK11360  546 DPELLKKIFDPFFT------TKAKgTGLGLALSQRII-NAHGGdIEVESEPGVGTTFTLYLPINPQ 604
CitA COG3290
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ...
 152-349 1.23e-16

Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];


Pssm-ID: 442519 [Multi-domain]  Cd Length: 389  Bit Score: 80.28  E-value: 1.23e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267444785 152 KEHREARETVESIREENNRILNGLDLALhmarleqfakdyKVEVVNVIdvIRGIINENRKSFIQSSVFPKVMFEeDTCMV 231
Cdd:COG3290   214 GEYDEALEYIDEISEELQELIDSLLSRI------------GNPVLAAL--LLGKAARARERGIDLTIDIDSDLP-DLPLS 278

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267444785 232 ASDrkwLSIAIGQIVVNAIKYTKISEAEKKEIQFQIEEKDQKVLLHIRDNGIGIPEQDVKRIFDP-FFTgvngrKTREAT 310
Cdd:COG3290   279 DTD---LVTILGNLLDNAIEAVEKLPEEERRVELSIRDDGDELVIEVEDSGPGIPEELLEKIFERgFST-----KLGEGR 350

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1267444785 311 GMGLYITKEICDNLHHGIYVQSAEGEGTTFTFQFAKDEE 349
Cdd:COG3290   351 GLGLALVKQIVEKYGGTIEVESEEGEGTVFTVRLPKEGE 389
HATPase_AtoS-like cd16943
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 245-341 4.30e-16

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.


Pssm-ID: 340419 [Multi-domain]  Cd Length: 105  Bit Score: 73.23  E-value: 4.30e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267444785 245 IVVNAIKytkiSEAEKKEIQFQIEEKDQKVLLHIRDNGIGIPEQDVKRIFDPFFTgvnGRKTREATGMGLYITKEICdNL 324
Cdd:cd16943    11 LLVNAAQ----AMEGRGRITIRTWAHVDQVLIEVEDTGSGIDPEILGRIFDPFFT---TKPVGEGTGLGLSLSYRII-QK 82

                          90
                  ....*....|....*...
gi 1267444785 325 HHG-IYVQSAEGEGTTFT 341
Cdd:cd16943    83 HGGtIRVASVPGGGTRFT 100
KinE COG5809
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ...
 134-344 9.59e-16

Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444511 [Multi-domain]  Cd Length: 489  Bit Score: 78.09  E-value: 9.59e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267444785 134 HQMKTPVSVIELVLQKF-GKEHREARETVESIREENNRILNGLDLALHMARleqfAKDYKVEVVNVIDVIRGIInenrkS 212
Cdd:COG5809   279 HEIRNPLTSLKGFIQLLkDTIDEEQKTYLDIMLSELDRIESIISEFLVLAK----PQAIKYEPKDLNTLIEEVI-----P 349

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267444785 213 FIQS-----SVFPKVMFEEDTCMVASDRKWLSIAIGQIVVNAIKYTkiseAEKKEIQFQIEEKDQ-KVLLHIRDNGIGIP 286
Cdd:COG5809   350 LLQPqallkNVQIELELEDDIPDILGDENQLKQVFINLLKNAIEAM----PEGGNITIETKAEDDdKVVISVTDEGCGIP 425

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267444785 287 EQDVKRIFDPFFTgvngrkTRE-ATGMGLYITKEICDNlHHG-IYVQSAEGEGTTFTFQF 344
Cdd:COG5809   426 EERLKKLGEPFYT------TKEkGTGLGLMVSYKIIEE-HGGkITVESEVGKGTTFSITL 478
HATPase_FilI-like cd16921
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 238-342 1.16e-14

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340398 [Multi-domain]  Cd Length: 105  Bit Score: 69.28  E-value: 1.16e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267444785 238 LSIAIGQIVVNAIKYTKISEAEKKEIQFQIEEKDQkvLLHIRDNGIGIPEQDVKRIFDpFFTGVNGRKTREATGMGLYIT 317
Cdd:cd16921     1 LGQVLTNLLGNAIKFRRPRRPPRIEVGAEDVGEEW--TFYVRDNGIGIDPEYAEKVFG-IFQRLHSREEYEGTGVGLAIV 77

                          90       100
                  ....*....|....*....|....*..
gi 1267444785 318 KEICDnlHHG--IYVQSAEGEGTTFTF 342
Cdd:cd16921    78 RKIIE--RHGgrIWLESEPGEGTTFYF 102
KinA COG5805
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ...
 134-346 6.82e-14

Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444507 [Multi-domain]  Cd Length: 496  Bit Score: 72.46  E-value: 6.82e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267444785 134 HQMKTPVSVIELVLQKFGKEHREARETVESIREENNRILNGLDLALHMARleqfAKDYKVEVVNVIDVIRGIINENRKSF 213
Cdd:COG5805   296 HEIRNPLTSIKGFLQLLQPGIEDKEEYFDIMLSELDRIESIISEFLALAK----PQAVNKEKENINELIQDVVTLLETEA 371

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267444785 214 IQSSVFPKVMFEEDTCMVASDRKWLSIAIGQIVVNAIkytkisEAEKK--EIQFQIEEKDQKVLLHIRDNGIGIPEQDVK 291
Cdd:COG5805   372 ILHNIQIRLELLDEDPFIYCDENQIKQVFINLIKNAI------EAMPNggTITIHTEEEDNSVIIRVIDEGIGIPEERLK 445

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1267444785 292 RIFDPFFTgvngrkTRE-ATGMGLYITKEICDNlHHG-IYVQSAEGEGTTFTFQFAK 346
Cdd:COG5805   446 KLGEPFFT------TKEkGTGLGLMVSYKIIEN-HNGtIDIDSKVGKGTTFTITLPL 495
HATPase_HupT_MifS-like cd16976
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 242-342 5.64e-13

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.


Pssm-ID: 340435 [Multi-domain]  Cd Length: 102  Bit Score: 64.40  E-value: 5.64e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267444785 242 IGQIVVNAIK--YTKISEAEKKEIQFQIEEKDQKVLLHIRDNGIGIPEQDVKRIFDPFFTgvnGRKTREATGMGLYITKE 319
Cdd:cd16976     1 IQQVLMNLLQnaLDAMGKVENPRIRIAARRLGGRLVLVVRDNGPGIAEEHLSRVFDPFFT---TKPVGKGTGLGLSISYG 77

                          90       100
                  ....*....|....*....|....*
gi 1267444785 320 ICDnlHHG--IYVQSAEGEGTTFTF 342
Cdd:cd16976    78 IVE--EHGgrLSVANEEGAGARFTF 100
HATPase_SpaK_NisK-like cd16975
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 234-344 7.69e-13

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.


Pssm-ID: 340434 [Multi-domain]  Cd Length: 107  Bit Score: 64.02  E-value: 7.69e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267444785 234 DRKWLSIAIGQIVVNAIKYTKiseaEKKEIQFQIEEKDQKVLLHIRDNGIGIPEQDVKRIFDPFFTGVNGRKTREATGMG 313
Cdd:cd16975     1 DTLLLSRALINIISNACQYAP----EGGTVSISIYDEEEYLYFEIWDNGHGFSEQDLKKALELFYRDDTSRRSGGHYGMG 76

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1267444785 314 LYITKEICdNLHHG-IYVQSAEGEGTTFTFQF 344
Cdd:cd16975    77 LYIAKNLV-EKHGGsLIIENSQKGGAEVTVKI 107
PRK09835 PRK09835
Cu(+)/Ag(+) sensor histidine kinase;
134-342 9.18e-13

Cu(+)/Ag(+) sensor histidine kinase;


Pssm-ID: 182101 [Multi-domain]  Cd Length: 482  Bit Score: 69.03  E-value: 9.18e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267444785 134 HQMKTP----VSVIELVLQKfGKEHREARETVESIREENNRILNGLDLALHMA-------RLEQFAKDYKVEVVNVIDVI 202
Cdd:PRK09835  271 HEIRTPitnlITQTEIALSQ-SRSQKELEDVLYSNLEELTRMAKMVSDMLFLAqadnnqlIPEKKMLDLADEVGKVFDFF 349

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267444785 203 RGIInENRKSFIQssvfpkvmFEEDTCMVASDRKWLSIAIGQIVVNAIKYTKISEAekkeIQFQIEEKDQKVLLHIRDNG 282
Cdd:PRK09835  350 EAWA-EERGVELR--------FVGDPCQVAGDPLMLRRAISNLLSNALRYTPAGEA----ITVRCQEVDHQVQLVVENPG 416

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1267444785 283 IGIPEQDVKRIFDPFFTgVNGRKTR--EATGMGLYITKEICDnLHHG-IYVQSaEGEGTTFTF 342
Cdd:PRK09835  417 TPIAPEHLPRLFDRFYR-VDPSRQRkgEGSGIGLAIVKSIVV-AHKGtVAVTS-DARGTRFVI 476
HATPase_DpiB-CitA-like cd16915
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 237-341 9.80e-13

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.


Pssm-ID: 340392 [Multi-domain]  Cd Length: 104  Bit Score: 63.85  E-value: 9.80e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267444785 237 WLSIaIGQIVVNAIKYTKISEAEKKEIQFQIEEKDQKVLLHIRDNGIGIPEQDVKRIFDpffTGVNGRKTREaTGMGLYI 316
Cdd:cd16915     1 LITI-VGNLIDNALDALAATGAPNKQVEVFLRDEGDDLVIEVRDTGPGIAPELRDKVFE---RGVSTKGQGE-RGIGLAL 75

                          90       100
                  ....*....|....*....|....*
gi 1267444785 317 TKEICDNLHHGIYVQSAEGEGTTFT 341
Cdd:cd16915    76 VRQSVERLGGSITVESEPGGGTTFS 100
HATPase_BasS-like cd16940
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 225-344 1.17e-12

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.


Pssm-ID: 340417 [Multi-domain]  Cd Length: 113  Bit Score: 63.96  E-value: 1.17e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267444785 225 EEDTCMVASDRKWLSIAIGQIVVNAIKYTkiseAEKKEIQFQIEEKDQKVLLhIRDNGIGIPEQDVKRIFDPFF--TGVN 302
Cdd:cd16940     1 SAADIQVQGDALLLFLLLRNLVDNAVRYS----PQGSRVEIKLSADDGAVIR-VEDNGPGIDEEELEALFERFYrsDGQN 75

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1267444785 303 GrktrEATGMGLYITKEICDnLHHG-IYVQSAEGEGTTFTFQF 344
Cdd:cd16940    76 Y----GGSGLGLSIVKRIVE-LHGGqIFLGNAQGGGLEAWVRL 113
HATPase_TmoS-FixL-DctS-like cd16920
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 245-342 2.06e-12

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340397 [Multi-domain]  Cd Length: 104  Bit Score: 62.80  E-value: 2.06e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267444785 245 IVVNAIKYTKISEAEKKE--IQFQIEEKDQkVLLHIRDNGIGIPEQDVKRIFDPFFTgvngrkTR-EATGMGLYITKEIC 321
Cdd:cd16920     8 LVRNGIEAMSEGGCERREltIRTSPADDRA-VTISVKDTGPGIAEEVAGQLFDPFYT------TKsEGLGMGLSICRSII 80

                          90       100
                  ....*....|....*....|..
gi 1267444785 322 DnLHHG-IYVQSAEGEGTTFTF 342
Cdd:cd16920    81 E-AHGGrLSVESPAGGGATFQF 101
PRK13837 PRK13837
two-component system VirA-like sensor kinase;
274-340 1.82e-11

two-component system VirA-like sensor kinase;


Pssm-ID: 237526 [Multi-domain]  Cd Length: 828  Bit Score: 65.47  E-value: 1.82e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1267444785 274 VLLHIRDNGIGIPEQDVKRIFDPFFTgvngrkTREA-TGMGLYITKEICDNLHHGIYVQSAEGEGTTF 340
Cdd:PRK13837  608 VLLRVSDTGAGIDEAVLPHIFEPFFT------TRAGgTGLGLATVHGIVSAHAGYIDVQSTVGRGTRF 669
PRK11091 PRK11091
aerobic respiration control sensor protein ArcB; Provisional
 248-341 1.07e-10

aerobic respiration control sensor protein ArcB; Provisional


Pssm-ID: 236842 [Multi-domain]  Cd Length: 779  Bit Score: 63.04  E-value: 1.07e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267444785 248 NAIKYTKiseaeKKEIQFQIE-EKDQKVLLHIRDNGIGIPEQDVKRIFDPFFTGVNGRKTREA--TGMGLYITKEICDNL 324
Cdd:PRK11091  409 NAVKFTQ-----QGGVTVRVRyEEGDMLTFEVEDSGIGIPEDELDKIFAMYYQVKDSHGGKPAtgTGIGLAVSKRLAQAM 483

                          90
                  ....*....|....*..
gi 1267444785 325 HHGIYVQSAEGEGTTFT 341
Cdd:PRK11091  484 GGDITVTSEEGKGSCFT 500
HATPase_EcPhoR-like cd16952
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 238-345 1.51e-10

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.


Pssm-ID: 340428 [Multi-domain]  Cd Length: 108  Bit Score: 57.60  E-value: 1.51e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267444785 238 LSIAIGQIVVNAIKYTKiseaEKKEIQFQIEEKDQKVLLHIRDNGIGIPEQDVKRIFDPFF-TGVNGRKTREATGMGLYI 316
Cdd:cd16952     1 LRSAFSNLVSNAVKYTP----PSDTITVRWSQEESGARLSVEDTGPGIPPEHIPRLTERFYrVDIERCRNTGGTGLGLAI 76

                          90       100
                  ....*....|....*....|....*....
gi 1267444785 317 TKEICDNLHHGIYVQSAEGEGTTFTFQFA 345
Cdd:cd16952    77 VKHVMSRHDARLLIASELGKGSRFTCLFP 105
HATPase_CpxA-like cd16949
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 238-328 1.66e-10

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.


Pssm-ID: 340425 [Multi-domain]  Cd Length: 104  Bit Score: 57.34  E-value: 1.66e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267444785 238 LSIAIGQIVVNAIKYTKiseaekKEIQFQIEEKDQKVLLHIRDNGIGIPEQDVKRIFDPFFTgVNGRKTREA--TGMGLY 315
Cdd:cd16949     1 LARALENVLRNALRYSP------SKILLDISQDGDQWTITITDDGPGVPEDQLEQIFLPFYR-VDSARDRESggTGLGLA 73

                          90
                  ....*....|...
gi 1267444785 316 ITKEICDnLHHGI 328
Cdd:cd16949    74 IAERAIE-QHGGK 85
envZ PRK09467
osmolarity sensor protein; Provisional
 241-327 2.08e-10

osmolarity sensor protein; Provisional


Pssm-ID: 236531 [Multi-domain]  Cd Length: 435  Bit Score: 61.85  E-value: 2.08e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267444785 241 AIGQIVVNAIKYT----KISEA-EKKEIQFQIEekdqkvllhirDNGIGIPEQDVKRIFDPFFTGVNGRKTrEATGMGLY 315
Cdd:PRK09467  335 ALANLVVNAARYGngwiKVSSGtEGKRAWFQVE-----------DDGPGIPPEQLKHLFQPFTRGDSARGS-SGTGLGLA 402

                          90
                  ....*....|..
gi 1267444785 316 ITKEICDNlHHG 327
Cdd:PRK09467  403 IVKRIVDQ-HNG 413
cpxA PRK09470
envelope stress sensor histidine kinase CpxA;
234-327 5.24e-10

envelope stress sensor histidine kinase CpxA;


Pssm-ID: 236532 [Multi-domain]  Cd Length: 461  Bit Score: 60.33  E-value: 5.24e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267444785 234 DRKWLSIAIGQIVVNAIKYTKiseaekKEIQFQIEEKDQKVLLHIRDNGIGIPEQDVKRIFDPFFTgVNGRKTREA--TG 311
Cdd:PRK09470  350 NPNALASALENIVRNALRYSH------TKIEVAFSVDKDGLTITVDDDGPGVPEEEREQIFRPFYR-VDEARDRESggTG 422

                          90
                  ....*....|....*.
gi 1267444785 312 MGLYITkEICDNLHHG 327
Cdd:PRK09470  423 LGLAIV-ENAIQQHRG 437
PRK10364 PRK10364
two-component system sensor histidine kinase ZraS;
134-341 5.42e-10

two-component system sensor histidine kinase ZraS;


Pssm-ID: 236674 [Multi-domain]  Cd Length: 457  Bit Score: 60.57  E-value: 5.42e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267444785 134 HQMKTPVSVIELVLQKFG---KEHREARETVESIREEN---NRILNGLDLALHMARLeqfakdyKVEVVNVIDVIRGIIN 207
Cdd:PRK10364  246 HEIRNPLSSIKGLAKYFAeraPAGGEAHQLAQVMAKEAdrlNRVVSELLELVKPTHL-------ALQAVDLNDLINHSLQ 318

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267444785 208 ------ENRKSFIQSSVFPKVmfeeDTCMVASDRkwLSIAIGQIVVNAIKytkiSEAEKKEIQFQIEEKDQKVLLHIRDN 281
Cdd:PRK10364  319 lvsqdaNSREIQLRFTANDTL----PEIQADPDR--LTQVLLNLYLNAIQ----AIGQHGVISVTASESGAGVKISVTDS 388

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1267444785 282 GIGIPEQDVKRIFDPFFTGVNgrktrEATGMGLYITKEICDNlHHG-IYVQSAEGEGTTFT 341
Cdd:PRK10364  389 GKGIAADQLEAIFTPYFTTKA-----EGTGLGLAVVHNIVEQ-HGGtIQVASQEGKGATFT 443
YesM COG2972
Sensor histidine kinase YesM [Signal transduction mechanisms];
244-349 1.67e-09

Sensor histidine kinase YesM [Signal transduction mechanisms];


Pssm-ID: 442211 [Multi-domain]  Cd Length: 445  Bit Score: 58.88  E-value: 1.67e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267444785 244 QIVV-NAIKYTKISEAEKKEIQFQIEEKDQKVLLHIRDNGIGIPEQDVKRIFDPFFTGVNGRktreatGMGLYITKEICD 322
Cdd:COG2972   342 QPLVeNAIEHGIEPKEGGGTIRISIRKEGDRLVITVEDNGVGMPEEKLEKLLEELSSKGEGR------GIGLRNVRERLK 415

                          90       100       110
                  ....*....|....*....|....*....|
gi 1267444785 323 NLH---HGIYVQSAEGEGTTFTFQFAKDEE 349
Cdd:COG2972   416 LYYgeeYGLEIESEPGEGTTVTIRIPLEEE 445
HATPase_CreC-like cd16945
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 234-340 1.84e-09

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.


Pssm-ID: 340421 [Multi-domain]  Cd Length: 106  Bit Score: 54.77  E-value: 1.84e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267444785 234 DRKWLSIAIGQIVVNAIKYTkiseAEKKEIQFQIEEKDQKVLLHIRDNGIGIPEQDVKRIFDPFFTGVNGRKTREATGMG 313
Cdd:cd16945     1 DPFLLRQAINNLLDNAIDFS----PEGGLIALQLEADTEGIELLVFDEGSGIPDYALNRVFERFYSLPRPHSGQKSTGLG 76

                          90       100
                  ....*....|....*....|....*...
gi 1267444785 314 LYITKEICdNLHHG-IYVQSAEGEGTTF 340
Cdd:cd16945    77 LAFVQEVA-QLHGGrITLRNRPDGVLAF 103
PRK10841 PRK10841
two-component system sensor histidine kinase RcsC;
248-341 1.85e-09

two-component system sensor histidine kinase RcsC;


Pssm-ID: 182772 [Multi-domain]  Cd Length: 924  Bit Score: 59.22  E-value: 1.85e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267444785 248 NAIKYTKISEaekkeIQFQIEEKDQKVLLHIRDNGIGIPEQDVKRIFDPFF-TGVNGRKTREATGMGLyitkEICD---N 323
Cdd:PRK10841  573 NAIKFTDTGC-----IVLHVRVDGDYLSFRVRDTGVGIPAKEVVRLFDPFFqVGTGVQRNFQGTGLGL----AICEkliN 643

                          90
                  ....*....|....*....
gi 1267444785 324 LHHG-IYVQSAEGEGTTFT 341
Cdd:PRK10841  644 MMDGdISVDSEPGMGSQFT 662
PRK11107 PRK11107
hybrid sensory histidine kinase BarA; Provisional
 242-342 1.91e-09

hybrid sensory histidine kinase BarA; Provisional


Pssm-ID: 236848 [Multi-domain]  Cd Length: 919  Bit Score: 59.09  E-value: 1.91e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267444785 242 IGQIVVN----AIKYTkiseaEKKEIQFQIEEK---DQKVLLH--IRDNGIGIPEQDVKRIFDPFftgvngrktREA--- 309
Cdd:PRK11107  409 LQQIITNlvgnAIKFT-----ESGNIDILVELRalsNTKVQLEvqIRDTGIGISERQQSQLFQAF---------RQAdas 474

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1267444785 310 -------TGMGLYITKEICDNLHHGIYVQSAEGEGTTFTF 342
Cdd:PRK11107  475 isrrhggTGLGLVITQKLVNEMGGDISFHSQPNRGSTFWF 514
HATPase_CckA-like cd16919
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ...
 274-340 1.96e-09

Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).


Pssm-ID: 340396 [Multi-domain]  Cd Length: 116  Bit Score: 54.69  E-value: 1.96e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267444785 274 VLLHIRDNGIGIPEQDVKRIFDPFFTgvngrkTRE---ATGMGLYITKEICDNLHHGIYVQSAEGEGTTF 340
Cdd:cd16919    48 VCLEVSDTGSGMPAEVLRRAFEPFFT------TKEvgkGTGLGLSMVYGFVKQSGGHLRIYSEPGVGTTV 111
PRK15347 PRK15347
two component system sensor kinase;
244-343 2.31e-09

two component system sensor kinase;


Pssm-ID: 237951 [Multi-domain]  Cd Length: 921  Bit Score: 58.89  E-value: 2.31e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267444785 244 QIVVN----AIKYTkiseaEKKEIQFQIEEKDQKVLLHIRDNGIGIPEQDVKRIFDPFF-TGVNgrktREATGMGLYITK 318
Cdd:PRK15347  516 QILVNllgnAVKFT-----ETGGIRLRVKRHEQQLCFTVEDTGCGIDIQQQQQIFTPFYqADTH----SQGTGLGLTIAS 586

                          90       100
                  ....*....|....*....|....*
gi 1267444785 319 EICDNLHHGIYVQSAEGEGTTFTFQ 343
Cdd:PRK15347  587 SLAKMMGGELTLFSTPGVGSCFSLV 611
RsbW COG2172
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
238-344 2.37e-09

Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];


Pssm-ID: 441775 [Multi-domain]  Cd Length: 127  Bit Score: 54.92  E-value: 2.37e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267444785 238 LSIAIGQIVVNAIKYTKiSEAEKKEIQFQIEEKDQKVLLHIRDNGIGIPEQDVKRIFDPFFTGvngrktreatGMGLYIT 317
Cdd:COG2172    35 LVLAVSEAVTNAVRHAY-GGDPDGPVEVELELDPDGLEIEVRDEGPGFDPEDLPDPYSTLAEG----------GRGLFLI 103

                          90       100
                  ....*....|....*....|....*..
gi 1267444785 318 KEICDNLHhgiyVQSAEGeGTTFTFQF 344
Cdd:COG2172   104 RRLMDEVE----YESDPG-GTTVRLVK 125
T2SS_HK NF038348
histidine kinase;
278-341 2.52e-09

histidine kinase;


Pssm-ID: 439642 [Multi-domain]  Cd Length: 574  Bit Score: 58.42  E-value: 2.52e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1267444785 278 IRDNGIGIPEQDVKRIFDPFFTgvnGRKTREATGMGLYITKEICDnlHHG--IYVQSAEGEGTTFT 341
Cdd:NF038348  508 ISDTGKGIPPDVMGRIFDPFFT---TKPVGQGTGLGLSISHGIVE--HHRgrIDVASEPGRGSTFT 568
HATPase_EnvZ-like cd16950
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 241-337 3.39e-09

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.


Pssm-ID: 340426 [Multi-domain]  Cd Length: 101  Bit Score: 53.61  E-value: 3.39e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267444785 241 AIGQIVVNAIKYTKI-----SEAEKKEIQFQIEekdqkvllhirDNGIGIPEQDVKRIFDPFFTGVNGRKTReATGMGLY 315
Cdd:cd16950     4 VLSNLVDNALRYGGGwvevsSDGEGNRTRIQVL-----------DNGPGIAPEEVDELFQPFYRGDNARGTS-GTGLGLA 71

                          90       100
                  ....*....|....*....|..
gi 1267444785 316 ITKEICDNLHHGIYVQSAEGEG 337
Cdd:cd16950    72 IVQRISDAHGGSLTLANRAGGG 93
phoR PRK11006
phosphate regulon sensor histidine kinase PhoR;
134-346 4.16e-09

phosphate regulon sensor histidine kinase PhoR;


Pssm-ID: 182895 [Multi-domain]  Cd Length: 430  Bit Score: 57.71  E-value: 4.16e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267444785 134 HQMKTPVSVIELVLQKFGKEHREAR---ETVESIREENNRiLNGL-DLALHMARLEQFAKDYKVEVVNVIDVIRGIINE- 208
Cdd:PRK11006  213 HELRTPLTVLQGYLEMMQDQPLEGAlreKALHTMREQTQR-MEGLvKQLLTLSKIEAAPTIDLNEKVDVPMMLRVLEREa 291

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267444785 209 ----NRKSFIQSSVFP--KVMFEEDTcmvasdrkwLSIAIGQIVVNAIKYTkiseAEKKEIQFQIEEKDQKVLLHIRDNG 282
Cdd:PRK11006  292 qtlsQGKHTITFEVDNslKVFGNEDQ---------LRSAISNLVYNAVNHT----PEGTHITVRWQRVPQGAEFSVEDNG 358

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1267444785 283 IGIPEQDVKRIFDPFFTgVNGRKTRE--ATGMGLYITKEICDNLHHGIYVQSAEGEGTTFTFQFAK 346
Cdd:PRK11006  359 PGIAPEHIPRLTERFYR-VDKARSRQtgGSGLGLAIVKHALSHHDSRLEIESEVGKGTRFSFVLPE 423
PRK11086 PRK11086
sensory histidine kinase DcuS; Provisional
 242-353 1.64e-08

sensory histidine kinase DcuS; Provisional


Pssm-ID: 236839 [Multi-domain]  Cd Length: 542  Bit Score: 56.07  E-value: 1.64e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267444785 242 IGQIVVNAIKytKISEAEKKEIQFQIEEKDQKVLLHIRDNGIGIPEQDVKRIFDP-FFTGVNGRktreatGMGLYITKEI 320
Cdd:PRK11086  438 LGNLIENALE--AVGGEEGGEISVSLHYRNGWLHCEVSDDGPGIAPDEIDAIFDKgYSTKGSNR------GVGLYLVKQS 509

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1267444785 321 CDNLHHGIYVQSAEGEGTTFTFQFAKDEEYHTL 353
Cdd:PRK11086  510 VENLGGSIAVESEPGVGTQFFVQIPWDGERSNR 542
HATPase_YcbM-like cd16947
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 245-341 1.94e-08

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).


Pssm-ID: 340423 [Multi-domain]  Cd Length: 125  Bit Score: 52.13  E-value: 1.94e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267444785 245 IVVNAIKYTkiseAEKKEIQFQIEEKDQKVLLHIRDNGIGIPEQDVKRIFDPFFTGVNGRKTR-EATGMGLYITKEICDN 323
Cdd:cd16947    28 LISNAIKYG----SDGKFLGMTLREDEKHVYIDIWDKGKGISETEKDHVFERLYTLEDSRNSAkQGNGLGLTITKRLAES 103

                          90
                  ....*....|....*...
gi 1267444785 324 LHHGIYVQSAEGEGTTFT 341
Cdd:cd16947   104 MGGSIYVNSKPYEKTVFT 121
PRK09959 PRK09959
acid-sensing system histidine kinase EvgS;
128-341 4.30e-08

acid-sensing system histidine kinase EvgS;


Pssm-ID: 182169 [Multi-domain]  Cd Length: 1197  Bit Score: 55.13  E-value: 4.30e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267444785  128 FMNQWIHQMKTPVSVIELVLQKFGKEHREARETVESIR---EENNRILNGLDLALHMARLEQFAKDYKVEVVNVIDVIR- 203
Cdd:PRK09959   715 FLATMSHEIRTPISSIMGFLELLSGSGLSKEQRVEAISlayATGQSLLGLIGEILDVDKIESGNYQLQPQWVDIPTLVQn 794

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267444785  204 -----GIINENRKSFIQ-SSVFPkvmfeeDTCMVASDRKWLSIAIGQIVVNAIKYTKISEAEKKEIQFQIEEKDQKVLLH 277
Cdd:PRK09959   795 tchsfGAIAASKSIALScSSTFP------DHYLVKIDPQAFKQVLSNLLSNALKFTTEGAVKITTSLGHIDDNHAVIKMT 868

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1267444785  278 IRDNGIGIPEQDVKRIFDPFFTGVNGRKtREATGMGLYITKEICDNLHHGIYVQSAEGEGTTFT 341
Cdd:PRK09959   869 IMDSGSGLSQEEQQQLFKRYSQTSAGRQ-QTGSGLGLMICKELIKNMQGDLSLESHPGIGTTFT 931
HATPase_VanS-like cd16923
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 245-340 4.77e-08

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.


Pssm-ID: 340400 [Multi-domain]  Cd Length: 102  Bit Score: 50.46  E-value: 4.77e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267444785 245 IVVNAIKYTKiseaEKKEIQFQIEEKDQKVLLHIRDNGIGIPEQDVKRIFDPFFTGVNGRKTrEATGMGLYITKEICDnL 324
Cdd:cd16923     8 LLSNAIKYSP----ENTRIYITSFLTDDVVNIMFKNPSSHPLDFKLEKLFERFYRGDNSRNT-EGAGLGLSIAKAIIE-L 81

                          90
                  ....*....|....*.
gi 1267444785 325 HHGIYVQSAEGEGTTF 340
Cdd:cd16923    82 HGGSASAEYDDNHDLF 97
PRK09303 PRK09303
histidine kinase;
248-342 8.13e-08

histidine kinase;


Pssm-ID: 236462 [Multi-domain]  Cd Length: 380  Bit Score: 53.42  E-value: 8.13e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267444785 248 NAIKYTKiseaEKKEIQFQIEEK-DQKVLLHIRDNGIGIPEQDVKRIFDPFFtgvngRKTR----EATGMGLYITKEICD 322
Cdd:PRK09303  283 NAIKYTP----EGGTITLSMLHRtTQKVQVSICDTGPGIPEEEQERIFEDRV-----RLPRdegtEGYGIGLSVCRRIVR 353

                          90       100
                  ....*....|....*....|.
gi 1267444785 323 NlHHG-IYVQSAEGEGTTFTF 342
Cdd:PRK09303  354 V-HYGqIWVDSEPGQGSCFHF 373
nifL_nitrog TIGR02938
nitrogen fixation negative regulator NifL; NifL is a modulator of the nitrogen fixation ...
 242-344 8.36e-08

nitrogen fixation negative regulator NifL; NifL is a modulator of the nitrogen fixation positive regulator protein NifA, and is therefore a negative regulator. It binds NifA. NifA and NifL are encoded by adjacent genes. [Central intermediary metabolism, Nitrogen fixation, Regulatory functions, Protein interactions]


Pssm-ID: 131984 [Multi-domain]  Cd Length: 494  Bit Score: 53.75  E-value: 8.36e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267444785 242 IGQIVVNAIKYTKISEAEKKEIQFQIEEKDQKVLLHIRDNGIGIPEQDVKRIFDPFFTGVNGrkTREATGMGLYITKEIC 321
Cdd:TIGR02938 392 FKALVDNAIEAMNIKGWKRRELSITTALNGDLIVVSILDSGPGIPQDLRYKVFEPFFTTKGG--SRKHIGMGLSVAQEIV 469

                          90       100
                  ....*....|....*....|....
gi 1267444785 322 dNLHHG-IYVQSAEGEGTTFTFQF 344
Cdd:TIGR02938 470 -ADHGGiIDLDDDYSEGCRIIVEF 492
PRK10490 PRK10490
sensor protein KdpD; Provisional
 96-342 1.21e-07

sensor protein KdpD; Provisional


Pssm-ID: 236701 [Multi-domain]  Cd Length: 895  Bit Score: 53.50  E-value: 1.21e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267444785  96 EQELIVESFTLLRQQYMNEVHKQHTKEQQQMIFMNQWI---------HQMKTPVSVI----ELVLQKFGKEHREARETVE 162
Cdd:PRK10490  626 EQQRLLETFTLLIANALERLTLTASEEQARLASEREQLrnallaalsHDLRTPLTVLfgqaEILTLDLASEGSPHARQAS 705

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267444785 163 SIREE---NNRILNGLdlaLHMARLEQFAKDYKVEVVNVIDVIRGIINENRKSFIQSSVfpKVMFEEDTCMVASDRKWLS 239
Cdd:PRK10490  706 EIRQQvlnTTRLVNNL---LDMARIQSGGFNLRKEWLTLEEVVGSALQMLEPGLSGHPI--NLSLPEPLTLIHVDGPLFE 780

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267444785 240 IAIGQIVVNAIKYTkiseAEKKEIQFQIEEKDQKVLLHIRDNGIGIPEQDVKRIFDPFftgvnGRKTREAT----GMGLY 315
Cdd:PRK10490  781 RVLINLLENAVKYA----GAQAEIGIDAHVEGERLQLDVWDNGPGIPPGQEQLIFDKF-----ARGNKESAipgvGLGLA 851

                         250       260
                  ....*....|....*....|....*...
gi 1267444785 316 ITKEICDnLHHG-IYVQSAEGEGTTFTF 342
Cdd:PRK10490  852 ICRAIVE-VHGGtIWAENRPEGGACFRV 878
HATPase_NtrY-like cd16944
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 234-337 8.69e-07

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.


Pssm-ID: 340420 [Multi-domain]  Cd Length: 108  Bit Score: 47.15  E-value: 8.69e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267444785 234 DRKWLSIAIGQIVVNAIKYTKISEAEKKEIQFQIE-EKDQKVLLHIRDNGIGIPEQDVKRIFDPFFTgvngrkTREA-TG 311
Cdd:cd16944     1 DTTQISQVLTNILKNAAEAIEGRPSDVGEVRIRVEaDQDGRIVLIVCDNGKGFPREMRHRATEPYVT------TRPKgTG 74

                          90       100
                  ....*....|....*....|....*.
gi 1267444785 312 MGLYITKEICDNLHHGIYVQSAEGEG 337
Cdd:cd16944    75 LGLAIVKKIMEEHGGRISLSNREAGG 100
HATPase_Glnl-NtrB-like cd16918
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 275-340 2.25e-06

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).


Pssm-ID: 340395 [Multi-domain]  Cd Length: 109  Bit Score: 45.85  E-value: 2.25e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1267444785 275 LLHIRDNGIGIPEQDVKRIFDPFFTG-VNGrktreaTGMGLYITKEICDnLHHG-IYVQSAEGEgTTF 340
Cdd:cd16918    45 RVSVIDNGPGIPPDLQDTIFYPMVSGrENG------TGLGLAIAQNIVS-QHGGvIECDSQPGH-TVF 104
PRK13557 PRK13557
histidine kinase; Provisional
 274-350 5.22e-06

histidine kinase; Provisional


Pssm-ID: 237425 [Multi-domain]  Cd Length: 540  Bit Score: 48.13  E-value: 5.22e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267444785 274 VLLHIRDNGIGIPEQDVKRIFDPFFTgvngrkTRE---ATGMGLYITKEICDNLHHGIYVQSAEGEGTTFTFQFAKDEEY 350
Cdd:PRK13557  325 VSIAVTDTGSGMPPEILARVMDPFFT------TKEegkGTGLGLSMVYGFAKQSGGAVRIYSEVGEGTTVRLYFPASDQA 398
HATPase_TutC-TodS-like cd16925
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ...
 273-343 7.07e-06

Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.


Pssm-ID: 340402 [Multi-domain]  Cd Length: 110  Bit Score: 44.41  E-value: 7.07e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1267444785 273 KVLLHIRDNGIGIPEQDVKRIFDPFFTG--VNGRKTReATGMGLYITKEICDnLHHG-IYVQSAEGEGTTFTFQ 343
Cdd:cd16925    37 RFLLTVSDSGPGIPPNLREEIFERFRQGdgSSTRAHG-GTGLGLSIVKEFVE-LHGGtVTVSDAPGGGALFQVE 108
HATPase_SpoIIAB-like cd16942
Histidine kinase-like ATPase domain of SpoIIAB, an anti sigma-F factor and serine-protein ...
 241-342 8.67e-06

Histidine kinase-like ATPase domain of SpoIIAB, an anti sigma-F factor and serine-protein kinase involved in regulating sigma-F during sporulation in Bacilli, and related domains; This family includes histidine kinase-like ATPase (HATPase) domain of SpoIIAB, an anti sigma-F factor and a serine-protein kinase involved in regulating sigma-F during sporulation in Bacilli where, early in sporulation, the cell divides into two unequal compartments: a larger mother cell and a smaller forespore. Sigma-F transcription factor is activated in the forespore directly after the asymmetric septum forms, and its spatial and temporal activation is required for sporulation. Free sigma-F can associate with the RNA polymerase core and activate transcription of the sigma-F regulon, its regulation may comprise a partner-switching mechanism involving SpoIIAB, SpoIIAA, and sigma-F as follows: SpoIIAB can form alternative complexes with either: i) sigma-F, holding it in an inactive form and preventing its association with RNA polymerase, or ii) unphosphorylated SpoIIAA and a nucleotide, either ATP or ADP. In the presence of ATP, SpoIIAB acts as a kinase to specifically phosphorylate a serine residue of SpoIIAA; this phosphorylated form has low affinity for SpoIIAB and dissociates, making SpoIIAB available to capture sigma-F. SpoIIAA may then be dephosphorylated by a SpoIIE serine phosphatase and be free to attack the SpoIIAB sigma-F complex to induce the release of sigma-F.


Pssm-ID: 340418 [Multi-domain]  Cd Length: 135  Bit Score: 44.84  E-value: 8.67e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267444785 241 AIGQIVVNAIKYTkISEAEKKEIQFQIEEKDQKVLLHIRDNGIGIPeqDVKRIFDPFFTgvnGRKTREATGMGLYITKEI 320
Cdd:cd16942    42 VVSEAVTNAIIHG-YNNDPNGIVSISVIIEDGVVHLTVRDEGVGIP--DIEEARQPLFT---TKPELERSGMGFTIMENF 115

                          90       100
                  ....*....|....*....|..
gi 1267444785 321 CDNLHhgiyVQSAEGEGTTFTF 342
Cdd:cd16942   116 MDEVI----VESEVNKGTTVYL 133
LytS COG3275
Sensor histidine kinase, LytS/YehU family [Signal transduction mechanisms];
248-344 1.09e-05

Sensor histidine kinase, LytS/YehU family [Signal transduction mechanisms];


Pssm-ID: 442506 [Multi-domain]  Cd Length: 352  Bit Score: 46.79  E-value: 1.09e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267444785 248 NAIKYTKISEAEKKEIQFQIEEKDQKVLLHIRDNGIGIPEqdvkrifdpfftgvngRKTREATGMGLYITKEICDNL--- 324
Cdd:COG3275   264 NAIKHGISSKEGGGTISISIEVEGDRLVIEVENNGVGIQP----------------KKKKKGSGIGLKNVRERLELLygd 327

                          90       100
                  ....*....|....*....|
gi 1267444785 325 HHGIYVQSAEGEGTTFTFQF 344
Cdd:COG3275   328 KYSLEIESTDGGGTKVTLKI 347
COG4192 COG4192
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ...
 130-333 1.21e-05

Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];


Pssm-ID: 443346 [Multi-domain]  Cd Length: 640  Bit Score: 46.99  E-value: 1.21e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267444785 130 NQWIHQMKTPVSVIELVLQKFGKEH-REARETVESIREENNRILNGLdlalhmarlEQFAK--DYKVEVVNVIDVIRG-- 204
Cdd:COG4192   445 NQPLNAMSMYLFSAKKALEQENYAQlPTSLDKIEGLIERMDKIIKSL---------RQFSRksDTPLQPVDLRQVIEQaw 515

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267444785 205 IINENRKSFIQSSvfpkvMFEEDTCMVASDrkwlSIAIGQIVVNAIKYTKISEAEKKEIQFQIEEKDQKVLLHIRDNGIG 284
Cdd:COG4192   516 ELVESRAKPQQIT-----LHIPDDLMVQGD----QVLLEQVLVNLLVNALDAVATQPQISVDLLSNAENLRVAISDNGNG 586

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 1267444785 285 IPeqDVKRIFDPFFTgvngrkTRE-ATGMGLYITKEICDNLHHGIYVQSA 333
Cdd:COG4192   587 WP--LVDKLFTPFTT------TKEvGLGLGLSICRSIMQQFGGDLYLAST 628
PRK10604 PRK10604
sensor protein RstB; Provisional
 232-342 3.14e-05

sensor protein RstB; Provisional


Pssm-ID: 236724 [Multi-domain]  Cd Length: 433  Bit Score: 45.36  E-value: 3.14e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267444785 232 ASDRKWLSIAIGQIVVNAIKYTKiseaekKEIQFQIEEKDQKVLLHIRDNGIGIPEQDVKRIFDPFftgVNGRKTRE-AT 310
Cdd:PRK10604  314 ALDMRLMERVLDNLLNNALRYAH------SRVRVSLLLDGNQACLIVEDDGPGIPPEERERVFEPF---VRLDPSRDrAT 384

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1267444785 311 ---GMGLYITKEICdnLHHG--IYVQSAEGEGTTFTF 342
Cdd:PRK10604  385 ggcGLGLAIVHSIA--LAMGgsVNCDESELGGARFSF 419
HATPase_BaeS-like cd16946
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 234-327 3.44e-05

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.


Pssm-ID: 340422 [Multi-domain]  Cd Length: 109  Bit Score: 42.45  E-value: 3.44e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267444785 234 DRKWLSIAIGQIVVNAIKYTKiseaEKKEIQFQIEEKDQKVLLHIRDNGIGIPEQDVKRIFDPFFTgVNGRKTREA--TG 311
Cdd:cd16946     1 DRDRLQQLFVNLLENSLRYTD----TGGKLRIRAAQTPQEVRLDVEDSAPGVSDDQLARLFERFYR-VESSRNRASggSG 75

                          90
                  ....*....|....*.
gi 1267444785 312 MGLYITKEICDnLHHG 327
Cdd:cd16946    76 LGLAICHNIAL-AHGG 90
COG3920 COG3920
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ...
 153-348 3.84e-05

Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];


Pssm-ID: 443125 [Multi-domain]  Cd Length: 495  Bit Score: 45.28  E-value: 3.84e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267444785 153 EHREARETVESIReenNRILngldlAlhMARL-EQFAKDYKVEVVNVIDVIRGIINENRKSFIQSSV-----FPKVMFEE 226
Cdd:COG3920   325 DDPEAREALEESQ---NRIQ-----A--LALVhELLYQSEDWEGVDLRDYLRELLEPLRDSYGGRGIrieldGPDVELPA 394

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267444785 227 DTCMVasdrkwLSIAIGQIVVNAIKYTkISEAEKKEIQFQIEEKDQKVLLHIRDNGIGIPEQdvkriFDPfftgvngrkt 306
Cdd:COG3920   395 DAAVP------LGLILNELVTNALKHA-FLSGEGGRIRVSWRREDGRLRLTVSDNGVGLPED-----VDP---------- 452

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 1267444785 307 REATGMGLYITKEICDNLHHGIyvQSAEGEGTTFTFQFAKDE 348
Cdd:COG3920   453 PARKGLGLRLIRALVRQLGGTL--ELDRPEGTRVRITFPLAE 492
HATPase_YpdA-YehU-LytS-like cd16924
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 245-343 5.25e-05

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YpdA, YehU, Bacillus subtilis LytS, and some hybrid sensor histidine kinases; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis LytS, a HK of the two-component system (TCS) LytS-LytR needed for growth on pyruvate, and Staphylococcus aureus LytS-LytR TCS involved in the adaptation of S. aureus to cationic antimicrobial peptides. It also includes the HATPase domains of Escherichia coli YpdA and YehU, HKs of YpdA-YpdB and YehU-YehTCSs, which are involved together in a nutrient sensing regulatory network. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), some having accessory sensor domain(s) such as Cache, HAMP or GAF; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340401 [Multi-domain]  Cd Length: 103  Bit Score: 41.66  E-value: 5.25e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267444785 245 IVVNAIKYTKISEAEKKEIQFQIEEKDQKVLLHIRDNGIGIpeqdvkrifDPFFTGVNGRKTREATGMGLYitkeicdNL 324
Cdd:cd16924     9 LVENAIQHGLSPLTDKGVVTISALKEDNHVMIEVEDNGRGI---------DPKVLNILGKKPKEGNGIGLY-------NV 72

                          90       100
                  ....*....|....*....|....*....
gi 1267444785 325 HH----------GIYVQSAEGEGTTFTFQ 343
Cdd:cd16924    73 HQrlillfgedyGIHIASEPDKGTRITFT 101
PRK11466 PRK11466
hybrid sensory histidine kinase TorS; Provisional
 242-343 8.46e-05

hybrid sensory histidine kinase TorS; Provisional


Pssm-ID: 236914 [Multi-domain]  Cd Length: 914  Bit Score: 44.51  E-value: 8.46e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267444785 242 IGQIVVN----AIKYTkiseaEKKEIQFQIEEKDQKVLLHIRDNGIGIPEQDVKRIFDPFFTgVNGRktREATGMGLYIT 317
Cdd:PRK11466  562 IRQVITNllsnALRFT-----DEGSIVLRSRTDGEQWLVEVEDSGCGIDPAKLAEIFQPFVQ-VSGK--RGGTGLGLTIS 633

                          90       100
                  ....*....|....*....|....*.
gi 1267444785 318 KEICDNLHHGIYVQSAEGEGTTFTFQ 343
Cdd:PRK11466  634 SRLAQAMGGELSATSTPEVGSCFCLR 659
HATPase_LytS-like cd16957
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 244-343 2.02e-04

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis LytS and Staphylococcus aureus LytS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis LytS, a HK of the two-component system (TCS) LytS-LytR needed for growth on pyruvate, and Staphylococcus aureus LytS-LytR TCS involved in the adaptation of S. aureus to cationic antimicrobial peptides. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), and a GAF sensor domain; most contain a DUF3816 domain.


Pssm-ID: 340433 [Multi-domain]  Cd Length: 106  Bit Score: 40.10  E-value: 2.02e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267444785 244 QIVV-NAIKYTKISEAEKKEIQFQIEEKDQKVLLHIRDNGIGIPEQDVKRIfdpfftgvnGRKT---REATGMGLYITKE 319
Cdd:cd16957     7 QVLVeNAIRHAFPKRKENNEVRVVVKKDQHKVHVSVSDNGQGIPEERLDLL---------GKTTvtsEKGTGTALENLNR 77

                          90       100
                  ....*....|....*....|....*..
gi 1267444785 320 ICDNLH---HGIYVQSAEGEGTTFTFQ 343
Cdd:cd16957    78 RLIGLFgseACLHIESEVHGGTEVWFV 104
HATPase_BvrS-ChvG-like cd16953
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 242-343 2.29e-04

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.


Pssm-ID: 340429 [Multi-domain]  Cd Length: 110  Bit Score: 40.25  E-value: 2.29e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267444785 242 IGQIVVNAIKYTK-ISEAEKKEIQFQIEEKDQKVLLHIRDNGIGIPEQDVKRIFDPFFTgvnGRKTREA----TGMGLYI 316
Cdd:cd16953     1 LGQVLRNLIGNAIsFSPPDTGRITVSAMPTGKMVTISVEDEGPGIPQEKLESIFDRFYT---ERPANEAfgqhSGLGLSI 77

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1267444785 317 TKEICDnLHHGIYV-----QSAEGEGTTFTFQ 343
Cdd:cd16953    78 SRQIIE-AHGGISVaenhnQPGQVIGARFTVQ 108
HATPase_c_2 pfam13581
Histidine kinase-like ATPase domain;
240-344 5.30e-04

Histidine kinase-like ATPase domain;


Pssm-ID: 433327 [Multi-domain]  Cd Length: 127  Bit Score: 39.58  E-value: 5.30e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267444785 240 IAIGQIVVNAIKYTKiSEAEKKEIQFQIEEKDQKVLLHIRDNGIG-----IPEQDVKRIFDPFFTGvngrktreatGMGL 314
Cdd:pfam13581  34 LAVGEACTNAVEHAY-REGPEGPVEVRLTSDGGGLVVTVADSGPPfdpltLPPPDLEEPDEDRKEG----------GRGL 102

                          90       100       110
                  ....*....|....*....|....*....|
gi 1267444785 315 YITKEICDNLHhgiYVqsAEGEGTTFTFQF 344
Cdd:pfam13581 103 ALIRGLMDDVE---YT--RGGEGNTVRMRK 127
spIIAB TIGR01925
anti-sigma F factor; This model describes the SpoIIAB anti-sigma F factor. Sigma F regulates ...
 238-339 7.65e-04

anti-sigma F factor; This model describes the SpoIIAB anti-sigma F factor. Sigma F regulates spore development in B subtilis. SpoIIAB binds to sigma F, preventing formation of the transcription complex at the promoter. SpoIIAA (anti-anti-sigma F factor) binds to SpoIIAB to inhibit association with sigma F, however SpoIIAB can phosphorylate SpoIIAA, causing disassociation of the SpoIIAA/B complex. The SpoIIE phosphatase dephosphorylates SpoIIAA. [Regulatory functions, Protein interactions, Cellular processes, Sporulation and germination]


Pssm-ID: 130980 [Multi-domain]  Cd Length: 137  Bit Score: 39.14  E-value: 7.65e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267444785 238 LSIAIGQIVVNAIKYtKISEAEKKEIQFQIEEKDQKVLLHIRDNGIGIpeQDVKRIFDPFFTgvnGRKTREATGMGLYIT 317
Cdd:TIGR01925  40 IKTAVSEAVTNAIIH-GYEENCEGVVYISATIEDHEVYITVRDEGIGI--ENLEEAREPLYT---SKPELERSGMGFTVM 113

                          90       100
                  ....*....|....*....|..
gi 1267444785 318 KEICDNLHhgiyVQSAEGEGTT 339
Cdd:TIGR01925 114 ENFMDDVS----VDSEKEKGTK 131
HATPase_RstB-like cd16939
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 238-342 1.15e-03

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.


Pssm-ID: 340416 [Multi-domain]  Cd Length: 104  Bit Score: 38.18  E-value: 1.15e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267444785 238 LSIAIGQIVVNAIKYTKiseaekKEIQFQIEEKDQKVLLHIRDNGIGIPEQDVKRIFDPFFTGVNGR-KTREATGMGLYI 316
Cdd:cd16939     1 MARALDNLLRNALRYAH------RTVRIALLVSGGRLTLIVEDDGPGIPAAARERVFEPFVRLDPSRdRATGGFGLGLAI 74

                          90       100
                  ....*....|....*....|....*...
gi 1267444785 317 TKEICdnLHHGIYVQSAEGE--GTTFTF 342
Cdd:cd16939    75 VHRVA--LWHGGHVECDDSElgGACFRL 100
PRK10935 PRK10935
nitrate/nitrite two-component system sensor histidine kinase NarQ;
246-344 1.25e-03

nitrate/nitrite two-component system sensor histidine kinase NarQ;


Pssm-ID: 236800 [Multi-domain]  Cd Length: 565  Bit Score: 40.61  E-value: 1.25e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267444785 246 VVNAIKYtkiSEAEKKEIQFQIEEkDQKVLLHIRDNGIGIPEQDvkrifdpfftgvngrktrEATG-MGLYITKEICDNL 324
Cdd:PRK10935  480 TLNAIKH---ANASEIAVSCVTNP-DGEHTVSIRDDGIGIGELK------------------EPEGhYGLNIMQERAERL 537

                          90       100
                  ....*....|....*....|
gi 1267444785 325 HHGIYVQSAEGEGTTFTFQF 344
Cdd:PRK10935  538 GGTLTISQPPGGGTTVSLTF 557
PRK11644 PRK11644
signal transduction histidine-protein kinase/phosphatase UhpB;
248-307 3.21e-03

signal transduction histidine-protein kinase/phosphatase UhpB;


Pssm-ID: 236945 [Multi-domain]  Cd Length: 495  Bit Score: 39.19  E-value: 3.21e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267444785 248 NAIKYtkiSEAEKKEIQFQIEekDQKVLLHIRDNGIGIPEQDVKRIFdpfftGVNGRKTR 307
Cdd:PRK11644  421 NIVKH---ADASAVTLQGWQQ--DERLMLVIEDDGSGLPPGSGQQGF-----GLRGMRER 470
ComP COG4585
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
246-344 3.68e-03

Signal transduction histidine kinase ComP [Signal transduction mechanisms];


Pssm-ID: 443642 [Multi-domain]  Cd Length: 252  Bit Score: 38.45  E-value: 3.68e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267444785 246 VVNAIKYtkiSEAekKEIQFQIEEKDQKVLLHIRDNGIGIPEQDVKRifdpfftgvngrktreaTGMGLYITKEICDNLH 325
Cdd:COG4585   171 LTNALKH---AGA--TRVTVTLEVDDGELTLTVRDDGVGFDPEAAPG-----------------GGLGLRGMRERAEALG 228

                          90
                  ....*....|....*....
gi 1267444785 326 HGIYVQSAEGEGTTFTFQF 344
Cdd:COG4585   229 GTLTIGSAPGGGTRVRATL 247
HisKA smart00388
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ...
 128-186 4.17e-03

His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.


Pssm-ID: 214644 [Multi-domain]  Cd Length: 66  Bit Score: 35.23  E-value: 4.17e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1267444785  128 FMNQWIHQMKTPVSVIELVLQKFGKEHR--EARETVESIREENNRILNGLDLALHMARLEQ 186
Cdd:smart00388   5 FLANLSHELRTPLTAIRGYLELLLDTELseEQREYLETILREAERLLRLINDLLDLSRIEA 65
HisKA pfam00512
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ...
 134-186 4.51e-03

His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.


Pssm-ID: 459839 [Multi-domain]  Cd Length: 66  Bit Score: 35.26  E-value: 4.51e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1267444785 134 HQMKTPVSVIELVLQKFGKEHR--EARETVESIREENNRILNGLDLALHMARLEQ 186
Cdd:pfam00512  11 HELRTPLTAIRGYLELLRDEKLdeEQREYLETILRSAERLLRLINDLLDLSRIEA 65
glnL PRK11073
nitrogen regulation protein NR(II);
278-341 4.77e-03

nitrogen regulation protein NR(II);


Pssm-ID: 182947 [Multi-domain]  Cd Length: 348  Bit Score: 38.52  E-value: 4.77e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1267444785 278 IRDNGIGIPEQDVKRIFDPFFTGVNGrktreATGMGLYITKEICDNlHHG-IYVQSAEGEgTTFT 341
Cdd:PRK11073  285 IEDNGPGIPPHLQDTLFYPMVSGREG-----GTGLGLSIARNLIDQ-HSGkIEFTSWPGH-TEFS 342
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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