|
Name |
Accession |
Description |
Interval |
E-value |
| KdpD |
COG2205 |
K+-sensing histidine kinase KdpD [Signal transduction mechanisms]; |
232-470 |
5.45e-65 |
|
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
Pssm-ID: 441807 [Multi-domain] Cd Length: 239 Bit Score: 209.76 E-value: 5.45e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267689820 232 ELKTSLYLQWKLEQERRDMVASIAHDLRTPLTIILSHVEVLMDPSLNGQKRLPQYLQTIKNNTQRVLHLTEEMKRVSEVD 311
Cdd:COG2205 1 ELEEALEELEELERLKSEFLANVSHELRTPLTSILGAAELLLDEEDLSPEERRELLEIIRESAERLLRLIEDLLDLSRLE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267689820 312 NPDFTLDIEGVIPIEMLPEMLEEFKKWAEDEEIKFTYSLNrkpgEGNSEFALDPKRLHQILTNLISNSIRFTPVNGSIDV 391
Cdd:COG2205 81 SGKLSLELEPVDLAELLEEAVEELRPLAEEKGIRLELDLP----PELPLVYADPELLEQVLANLLDNAIKYSPPGGTITI 156
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1267689820 392 QVQIEKDMMSFSICDTGKGFDTKDLPFLFSKFYQGDPSRNDQlHHGLGLYIVKELVIKHGGEIHARNNEPQGACIEFTI 470
Cdd:COG2205 157 SARREGDGVRISVSDNGPGIPEEELERIFERFYRGDNSRGEG-GTGLGLAIVKRIVEAHGGTIWVESEPGGGTTFTVTL 234
|
|
| WalK |
COG5002 |
Sensor histidine kinase WalK [Signal transduction mechanisms]; |
143-470 |
1.47e-64 |
|
Sensor histidine kinase WalK [Signal transduction mechanisms];
Pssm-ID: 444026 [Multi-domain] Cd Length: 390 Bit Score: 213.65 E-value: 1.47e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267689820 143 VLAVRYVLASSIDYYIKYIFLIILLIPFLFLTLYSYVFARRFGKELNKPIKELSAASQKIKNQDLDFEIKYESENEIGVL 222
Cdd:COG5002 61 LLLLLLALLLLLLLLLLLLALALLLLALLLLLLLLLLLLALLILLLLLALLILLAALLLLLSELLLLLLLLGRLSLRLSA 140
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267689820 223 IDSFNSMKEELKTSLYLQWKLEQERRDMVASIAHDLRTPLTIILSHVEVLMDPSLNGQKRLPQYLQTIKNNTQRVLHLTE 302
Cdd:COG5002 141 LLLGLLLLAAVERDITELERLEQMRREFVANVSHELRTPLTSIRGYLELLLDGAADDPEERREYLEIILEEAERLSRLVN 220
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267689820 303 EMKRVSEVDNPDFTLDIEGVIPIEMLPEMLEEFKKWAEDEEIKFTYSLNrkpgEGNSEFALDPKRLHQILTNLISNSIRF 382
Cdd:COG5002 221 DLLDLSRLESGELKLEKEPVDLAELLEEVVEELRPLAEEKGIELELDLP----EDPLLVLGDPDRLEQVLTNLLDNAIKY 296
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267689820 383 TPVNGSIDVQVQIEKDMMSFSICDTGKGFDTKDLPFLFSKFYQGDPSRNDQLH-HGLGLYIVKELVIKHGGEIHARNNEP 461
Cdd:COG5002 297 TPEGGTITVSLREEDDQVRISVRDTGIGIPEEDLPRIFERFYRVDKSRSRETGgTGLGLAIVKHIVEAHGGRIWVESEPG 376
|
....*....
gi 1267689820 462 QGACIEFTI 470
Cdd:COG5002 377 KGTTFTITL 385
|
|
| BaeS |
COG0642 |
Signal transduction histidine kinase [Signal transduction mechanisms]; |
242-470 |
1.23e-60 |
|
Signal transduction histidine kinase [Signal transduction mechanisms];
Pssm-ID: 440407 [Multi-domain] Cd Length: 328 Bit Score: 201.29 E-value: 1.23e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267689820 242 KLEQERRDMVASIAHDLRTPLTIILSHVEVLMDpslNGQKRLPQYLQTIKNNTQRVLHLTEEMKRVSEVDNPDFTLDIEG 321
Cdd:COG0642 105 EANEAKSRFLANVSHELRTPLTAIRGYLELLLE---ELDEEQREYLETILRSADRLLRLINDLLDLSRLEAGKLELEPEP 181
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267689820 322 VIPIEMLPEMLEEFKKWAEDEEIKFTYSLNRKPGEGNSefalDPKRLHQILTNLISNSIRFTPVNGSIDVQVQIEKDMMS 401
Cdd:COG0642 182 VDLAELLEEVVELFRPLAEEKGIELELDLPDDLPTVRG----DPDRLRQVLLNLLSNAIKYTPEGGTVTVSVRREGDRVR 257
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1267689820 402 FSICDTGKGFDTKDLPFLFSKFYQGDPSRNDQlHHGLGLYIVKELVIKHGGEIHARNNEPQGACIEFTI 470
Cdd:COG0642 258 ISVEDTGPGIPPEDLERIFEPFFRTDPSRRGG-GTGLGLAIVKRIVELHGGTIEVESEPGKGTTFTVTL 325
|
|
| NtrY |
COG5000 |
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ... |
156-471 |
1.49e-39 |
|
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];
Pssm-ID: 444024 [Multi-domain] Cd Length: 422 Bit Score: 147.80 E-value: 1.49e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267689820 156 YYIKYIFLIILLIPFLFLTLYSYVFARRFGKELNKPIKELSAASQKIKNQDLDFEIKYESENEIGVLIDSFNSMKEELKT 235
Cdd:COG5000 1 SGLQILFLLLLLLIALLLLLLALWLALLLARRLTRPLRRLAEATRAVAAGDLSVRLPVTGDDEIGELARAFNRMTDQLKE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267689820 236 S--------LYLQWKLE--------------------------------------------------------------- 244
Cdd:COG5000 81 QreeleerrRYLETILEnlpagvivldadgritlanpaaerllgipleeligkpleellpeldlaellrealergwqeei 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267689820 245 ----------------------------------QER----RDMVASIAHDLRTPLTIILSHVEVLM----DPSLNGQKR 282
Cdd:COG5000 161 eltrdgrrtllvrasplrddgyvivfdditellrAERlaawGELARRIAHEIKNPLTPIQLSAERLRrklaDKLEEDRED 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267689820 283 LPQYLQTIKNNTQRVLHLTEEMKRVSEVDNPDFT-LDIEgvipiEMLPEMLEEFKKWAEDEEIKFTYSLNrkpgEGNSEF 361
Cdd:COG5000 241 LERALDTIIRQVDRLKRIVDEFLDFARLPEPQLEpVDLN-----ELLREVLALYEPALKEKDIRLELDLD----PDLPEV 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267689820 362 ALDPKRLHQILTNLISNSIRFTPVNGSIDVQVQIEKDMMSFSICDTGKGFDTKDLPFLFSKFY----QGdpsrndqlhHG 437
Cdd:COG5000 312 LADRDQLEQVLINLLKNAIEAIEEGGEIEVSTRREDGRVRIEVSDNGPGIPEEVLERIFEPFFttkpKG---------TG 382
|
410 420 430
....*....|....*....|....*....|....
gi 1267689820 438 LGLYIVKELVIKHGGEIHARNNEPQGACieFTIS 471
Cdd:COG5000 383 LGLAIVKKIVEEHGGTIELESRPGGGTT--FTIR 414
|
|
| cztS_silS_copS |
TIGR01386 |
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ... |
85-471 |
4.34e-36 |
|
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.
Pssm-ID: 273593 [Multi-domain] Cd Length: 457 Bit Score: 138.67 E-value: 4.34e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267689820 85 EGITYQVINLRGNKIYGTLDD----QLIENNKSIYEkvnrSDQKGKVITKYLPILDKN----RMEGVLAVRYVLASSIDY 156
Cdd:TIGR01386 79 SDLALSILNPDGRLLFERAQGaalvPAVAANDALLE----LDQADAKMTHYRSILRSVaalpGGKGRKPVQITVALDINA 154
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267689820 157 -------YIKYIFLIILLIpFLFLTLYSYVFARRfgkELnKPIKELSAASQKIKNQDLDFEIKYE-SENEIGVLIDSFNS 228
Cdd:TIGR01386 155 hthlldaLRKWLILIAVLL-VLLTALLGWWITRL---GL-EPLRRLSAVAARISPESLDQRLDPSrAPAELRELAQSFNA 229
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267689820 229 MKEELKTSLYlqwKLEQerrdMVASIAHDLRTPLTIILSHVEVLmdpsLNGQKRLPQYLQTIKNNT---QRVLHLTEEMK 305
Cdd:TIGR01386 230 MLGRLEDAFQ---RLSQ----FSADLAHELRTPLTNLLGQTQVA----LSQPRTGEEYREVLESNLeelERLSRMVSDML 298
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267689820 306 RVSEVDNPDFTLDIEGVIPIEMLPEMLEEFKKWAEDEEIKFTYslnrkpgEGNSEFALDPKRLHQILTNLISNSIRFTPV 385
Cdd:TIGR01386 299 FLARADNGQLALERVRLDLAAELAKVAEYFEPLAEERGVRIRV-------EGEGLVRGDPQMFRRAISNLLSNALRHTPD 371
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267689820 386 NGSIDVQVQIEKDMMSFSICDTGKGFDTKDLPFLFSKFYQGDPSR-NDQLHHGLGLYIVKELVIKHGGEIHArnnEPQGA 464
Cdd:TIGR01386 372 GGTITVRIERRSDEVRVSVSNPGPGIPPEHLSRLFDRFYRVDPARsNSGEGTGLGLAIVRSIMEAHGGRASA---ESPDG 448
|
....*..
gi 1267689820 465 CIEFTIS 471
Cdd:TIGR01386 449 KTRFILR 455
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
364-470 |
2.70e-35 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 126.99 E-value: 2.70e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267689820 364 DPKRLHQILTNLISNSIRFTPVNGSIDVQVQIEKDMMSFSICDTGKGFDTKDLPFLFSKFYQGDPSRNDQLHHGLGLYIV 443
Cdd:smart00387 2 DPDRLRQVLSNLLDNAIKYTPEGGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDKRSRKIGGTGLGLSIV 81
|
90 100
....*....|....*....|....*..
gi 1267689820 444 KELVIKHGGEIHARNNEPQGACIEFTI 470
Cdd:smart00387 82 KKLVELHGGEISVESEPGGGTTFTITL 108
|
|
| COG4191 |
COG4191 |
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ... |
138-470 |
1.65e-31 |
|
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];
Pssm-ID: 443345 [Multi-domain] Cd Length: 361 Bit Score: 124.14 E-value: 1.65e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267689820 138 NRMEGVLAVRYVLASSIDYYIKYIFLIILLIPFLFLTLYSYVFARRFGKELNKPIKELSAASQKIKNQDLDFEIKYESEN 217
Cdd:COG4191 17 ALALALALLLLLLLLLLALLLLLLALLLALLALLLLLLLLLLLLLLELLLLLLALLGGLLRLLLLLGLLLLLLLEALLLL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267689820 218 EIGVLIDSFNSMKEELKTSLYLQWKLEQERRD----------------MVASIAHDLRTPLTIILSHVEVLMD--PSLNG 279
Cdd:COG4191 97 LLAALDAEENAELEELERDITELERAEEELRElqeqlvqseklaalgeLAAGIAHEINNPLAAILGNAELLRRrlEDEPD 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267689820 280 QKRLPQYLQTIKNNTQRVLHLTEEMKRVSEVDNPDFT-LDIEGVIPiEMLpEMLE-EFKKwaedEEIKFTYSLnrkpGEG 357
Cdd:COG4191 177 PEELREALERILEGAERAAEIVRSLRAFSRRDEEEREpVDLNELID-EAL-ELLRpRLKA----RGIEVELDL----PPD 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267689820 358 NSEFALDPKRLHQILTNLISNSIRFTP--VNGSIDVQVQIEKDMMSFSICDTGKGFDTKDLPFLFSKFY------QGdps 429
Cdd:COG4191 247 LPPVLGDPGQLEQVLLNLLINAIDAMEegEGGRITISTRREGDYVVISVRDNGPGIPPEVLERIFEPFFttkpvgKG--- 323
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 1267689820 430 rndqlhHGLGLYIVKELVIKHGGEIHARNNEPQGACIEFTI 470
Cdd:COG4191 324 ------TGLGLSISYGIVEKHGGRIEVESEPGGGTTFTITL 358
|
|
| HATPase |
cd00075 |
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ... |
368-470 |
5.27e-30 |
|
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.
Pssm-ID: 340391 [Multi-domain] Cd Length: 102 Bit Score: 112.31 E-value: 5.27e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267689820 368 LHQILTNLISNSIRFTPVNGSIDVQVQIEKDMMSFSICDTGKGFDTKDLPFLFSKFYQGDPSRNDQlHHGLGLYIVKELV 447
Cdd:cd00075 1 LEQVLSNLLDNALKYSPPGGTIEISLRQEGDGVVLEVEDNGPGIPEEDLERIFERFYRGDKSREGG-GTGLGLAIVRRIV 79
|
90 100
....*....|....*....|...
gi 1267689820 448 IKHGGEIHARNNEPQGACIEFTI 470
Cdd:cd00075 80 EAHGGRITVESEPGGGTTFTVTL 102
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
364-470 |
4.91e-28 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 107.45 E-value: 4.91e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267689820 364 DPKRLHQILTNLISNSIRFTPVNGSIDVQVQiEKDMMSFSICDTGKGFDTKDLPFLFSKFYQGDpsRNDQLHHGLGLYIV 443
Cdd:pfam02518 2 DELRLRQVLSNLLDNALKHAAKAGEITVTLS-EGGELTLTVEDNGIGIPPEDLPRIFEPFSTAD--KRGGGGTGLGLSIV 78
|
90 100
....*....|....*....|....*..
gi 1267689820 444 KELVIKHGGEIHARNNEPQGACIEFTI 470
Cdd:pfam02518 79 RKLVELLGGTITVESEPGGGTTVTLTL 105
|
|
| COG4251 |
COG4251 |
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ... |
134-470 |
7.95e-27 |
|
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];
Pssm-ID: 443393 [Multi-domain] Cd Length: 503 Bit Score: 112.96 E-value: 7.95e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267689820 134 ILDKNRMEGVLAVRYVLASSIDYYIKYIFLIILLIPFLFLTLYSYVFARRFGKELNKPIKELSAASQKIKNQDLDFEIKY 213
Cdd:COG4251 155 LLLLLLLLLLALILALLLAALAELELLLLLLLVLLLLLLLLLLLLLLLLRLLLELLLLLEAELLLSLGGGLGLLLLLLLL 234
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267689820 214 ESENEIGVLIDSFNSMKEELKTSLYLQWKLEQERRDMVA--------------SIAHDLRTPLTIILSHVEVL---MDPS 276
Cdd:COG4251 235 LVLLLLLILLLLLLILVLELLELRLELEELEEELEERTAelersneeleqfayVASHDLREPLRKISGFSQLLeedYGDK 314
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267689820 277 LNGQKRlpQYLQTIKNNTQRVLHLTE---EMKRVSEVDNPDFTLDIEgvipiEMLPEMLEEFKKWAEDEEIKFTYslnrk 353
Cdd:COG4251 315 LDEEGR--EYLERIRDAAERMQALIDdllAYSRVGRQELEFEPVDLN-----ELLEEVLEDLEPRIEERGAEIEV----- 382
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267689820 354 pgEGNSEFALDPKRLHQILTNLISNSIRFTP--VNGSIDVQVQIEKDMMSFSICDTGKGFDTKDLPFLFSKFYQGDpSRN 431
Cdd:COG4251 383 --GPLPTVRGDPTLLRQVFQNLISNAIKYSRpgEPPRIEIGAEREGGEWVFSVRDNGIGIDPEYAEKIFEIFQRLH-SRD 459
|
330 340 350
....*....|....*....|....*....|....*....
gi 1267689820 432 DQLHHGLGLYIVKELVIKHGGEIHARNNEPQGACIEFTI 470
Cdd:COG4251 460 EYEGTGIGLAIVKKIVERHGGRIWVESEPGEGATFYFTL 498
|
|
| PRK09835 |
PRK09835 |
Cu(+)/Ag(+) sensor histidine kinase; |
148-454 |
1.59e-26 |
|
Cu(+)/Ag(+) sensor histidine kinase;
Pssm-ID: 182101 [Multi-domain] Cd Length: 482 Bit Score: 111.79 E-value: 1.59e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267689820 148 YVL--ASSIDYYIKYI-----------FLIILLIPFLFLtlysyvFARRFGkelNKPIKELSAASQKIKNQDLDFEIKYE 214
Cdd:PRK09835 165 YTLliALSIDFHLHYIndlknklimtaSVISLLIVFIVL------LAVHKG---HAPIRSVSRQIQNITSKDLDVRLDPQ 235
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267689820 215 S-ENEIGVLIDSFNSMKEELKTSLYLQwkleqerRDMVASIAHDLRTPLTIILSHVEVLMDPSlNGQKRLPQYLQTIKNN 293
Cdd:PRK09835 236 TvPIELEQLVLSFNHMIERIEDVFTRQ-------SNFSADIAHEIRTPITNLITQTEIALSQS-RSQKELEDVLYSNLEE 307
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267689820 294 TQRVLHLTEEMKRVSEVDNPDFTLDiegVIPIEMLPEML---EEFKKWAEDEEIkfTYSLNRKPgegnSEFALDPKRLHQ 370
Cdd:PRK09835 308 LTRMAKMVSDMLFLAQADNNQLIPE---KKMLDLADEVGkvfDFFEAWAEERGV--ELRFVGDP----CQVAGDPLMLRR 378
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267689820 371 ILTNLISNSIRFTPVNGSIDVQVQIEKDMMSFSICDTGKGFDTKDLPFLFSKFYQGDPSRNDQLH-HGLGLYIVKELVIK 449
Cdd:PRK09835 379 AISNLLSNALRYTPAGEAITVRCQEVDHQVQLVVENPGTPIAPEHLPRLFDRFYRVDPSRQRKGEgSGIGLAIVKSIVVA 458
|
....*
gi 1267689820 450 HGGEI 454
Cdd:PRK09835 459 HKGTV 463
|
|
| HATPase_SpaK_NisK-like |
cd16975 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
364-470 |
2.55e-26 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.
Pssm-ID: 340434 [Multi-domain] Cd Length: 107 Bit Score: 102.54 E-value: 2.55e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267689820 364 DPKRLHQILTNLISNSIRFTPVNGSIDVQVQIEKDMMSFSICDTGKGFDTKDLPFLFSKFYQGDPSRNDQLHHGLGLYIV 443
Cdd:cd16975 1 DTLLLSRALINIISNACQYAPEGGTVSISIYDEEEYLYFEIWDNGHGFSEQDLKKALELFYRDDTSRRSGGHYGMGLYIA 80
|
90 100
....*....|....*....|....*..
gi 1267689820 444 KELVIKHGGEIHARNNEPQGACIEFTI 470
Cdd:cd16975 81 KNLVEKHGGSLIIENSQKGGAEVTVKI 107
|
|
| HATPase_EvgS-ArcB-TorS-like |
cd16922 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ... |
368-470 |
9.10e-24 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340399 [Multi-domain] Cd Length: 110 Bit Score: 95.64 E-value: 9.10e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267689820 368 LHQILTNLISNSIRFTPvNGSIDVQVQIEKD-----MMSFSICDTGKGFDTKDLPFLFSKFYQGDPSRNDQlhH---GLG 439
Cdd:cd16922 1 LRQILLNLLGNAIKFTE-EGEVTLRVSLEEEeedgvQLRFSVEDTGIGIPEEQQARLFEPFSQADSSTTRK--YggtGLG 77
|
90 100 110
....*....|....*....|....*....|.
gi 1267689820 440 LYIVKELVIKHGGEIHARNNEPQGACIEFTI 470
Cdd:cd16922 78 LAISKKLVELMGGDISVESEPGQGSTFTFTL 108
|
|
| PRK11100 |
PRK11100 |
sensory histidine kinase CreC; Provisional |
133-470 |
2.12e-23 |
|
sensory histidine kinase CreC; Provisional
Pssm-ID: 236846 [Multi-domain] Cd Length: 475 Bit Score: 102.62 E-value: 2.12e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267689820 133 PILDKNRMEGVLAVryvlA---SSIDYYIK-----------YIFLIILLIpFLFLTLYsyvfarrfgkeLNKPIKELSAA 198
Cdd:PRK11100 153 PIRDGGRIIGVLSV----GkpnSSMAPFIKrserrilwagaLLLGIALLI-GAGVVWW-----------LNRSIRRLTRY 216
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267689820 199 SQKIKNQDlDFEIKYESENEIGVLIDSFNSMKEELKTSLYLQwkleqerrDMVASIAHDLRTPLTIILSHVEvLMDPSLN 278
Cdd:PRK11100 217 ADAVTEGK-PVPLPKLGSSELRELAQALESMRVKLEGKAYVE--------QYVQTLTHELKSPLAAIRGAAE-LLQEDPP 286
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267689820 279 GQKRLpQYLQTIKNNTQRVLHLTEEMKRVSEVDNPDFTLDIEGVIPIEMLPEMLEEFKKWAEDEEIKFTYSLNRKPGEGN 358
Cdd:PRK11100 287 PEDRA-RFTGNILTQSARLQQLIDRLLELARLEQRQELEVLEPVALAALLEELVEAREAQAAAKGITLRLRPDDARVLGD 365
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267689820 359 SEFaldpkrLHQILTNLISNSIRFTPVNGSIDVQVQIEKDMMSFSICDTGKGFDTKDLPFLFSKFY------QGDPSRnd 432
Cdd:PRK11100 366 PFL------LRQALGNLLDNAIDFSPEGGTITLSAEVDGEQVALSVEDQGPGIPDYALPRIFERFYslprpaNGRKST-- 437
|
330 340 350
....*....|....*....|....*....|....*...
gi 1267689820 433 qlhhGLGLYIVKELVIKHGGEIHARNNEPQGACIEFTI 470
Cdd:PRK11100 438 ----GLGLAFVREVARLHGGEVTLRNRPEGGVLATLTL 471
|
|
| AdeS_HK |
NF012226 |
two-component sensor histidine kinase AdeS; Mutations in this component of the two-component ... |
160-471 |
2.76e-23 |
|
two-component sensor histidine kinase AdeS; Mutations in this component of the two-component regulatory system for the AdeABC efflux pump can confer adaptive resistance to certain antibiotics, including tigecycline.
Pssm-ID: 411090 [Multi-domain] Cd Length: 353 Bit Score: 100.84 E-value: 2.76e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267689820 160 YIFLIILlipflFLTLYSYVFARRFGKELNKPIKELSAASQKIKNQDLDFEIK--YESENEIGVLIDSFNSMKEELKTSL 237
Cdd:NF012226 61 WLFTVIL-----CGSVISLIIGMKLAQRFIVPINFLADAAKKISQGDLSARAEdsQIHSAEISELMHNFNDMAQKLESSV 135
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267689820 238 Y--LQWKleqerrdmvASIAHDLRTPLTIILSHVEVLMDPSLNGQKRLpqyLQTIKNNTQRVLHLTEEMKRVSEVDNPDF 315
Cdd:NF012226 136 KnaQVWN---------AAIAHELRTPITILQGRLQGILDGVFEPDPAL---FKSLLNQVEGLSHLVEDLRTLSLVENQQL 203
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267689820 316 TLDIEGVIPIEMLPEMLEEFKKWAEDEEIKFTYSLNrkpgegNSEFALDPKRLHQILTNLISNSIRFTPVnGSIDVQVQI 395
Cdd:NF012226 204 RLNYESVDLKDSIEKVLKMFEDRLEQAQLTIVLNLT------ATPVFCDRRRIEQVLIALIDNAIRYANA-GKLKISSSV 276
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1267689820 396 EKDMMSFSICDTGKGFDTKDLPFLFSKFYQGDPSRNDQL-HHGLGLYIVKELVIKHGGEIHARNnePQGACIeFTIS 471
Cdd:NF012226 277 IQDDWILQIEDEGPGIAEEYQQDLFNPFFRLEQSRNKEFgGTGLGLAVVHAIVIAHKGSIEYSN--SQGNSV-FTIK 350
|
|
| PRK10549 |
PRK10549 |
two-component system sensor histidine kinase BaeS; |
190-456 |
4.39e-23 |
|
two-component system sensor histidine kinase BaeS;
Pssm-ID: 182539 [Multi-domain] Cd Length: 466 Bit Score: 101.63 E-value: 4.39e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267689820 190 KPIKELSAASQKIKNQDLDFEIKYESENEIGVLIDSFNsmkeELKTSLYlqwKLEQERRDMVASIAHDLRTPLTIILSHV 269
Cdd:PRK10549 190 APVKRLVEGTHKLAAGDFTTRVTPTSRDELGRLAQDFN----QLASTLE---KNEQMRRDFMADISHELRTPLAVLRGEL 262
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267689820 270 EVLMDpslnGQKRL-PQYLQTIKNNTQRVLHLTEEMKRVSEVDNPDFTLDIEGVIPIEMLPEMLEEFKKWAEDEEIKFTY 348
Cdd:PRK10549 263 EAIQD----GVRKFtPESVASLQAEVGTLTKLVDDLHQLSLSDEGALAYRKTPVDLVPLLEVAGGAFRERFASRGLTLQL 338
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267689820 349 SLnrkpGEGNSEFAlDPKRLHQILTNLISNSIRFTPVNGSIDVQVQIEKDMMSFSICDTGKGFDTKDLPFLFSKFYQGDP 428
Cdd:PRK10549 339 SL----PDSATVFG-DPDRLMQLFNNLLENSLRYTDSGGSLHISAEQRDKTLRLTFADSAPGVSDEQLQKLFERFYRTEG 413
|
250 260
....*....|....*....|....*....
gi 1267689820 429 SRNDQL-HHGLGLYIVKELVIKHGGEIHA 456
Cdd:PRK10549 414 SRNRASgGSGLGLAICLNIVEAHNGRIIA 442
|
|
| phoR |
PRK11006 |
phosphate regulon sensor histidine kinase PhoR; |
242-470 |
2.49e-21 |
|
phosphate regulon sensor histidine kinase PhoR;
Pssm-ID: 182895 [Multi-domain] Cd Length: 430 Bit Score: 95.85 E-value: 2.49e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267689820 242 KLEQERRDMVASIAHDLRTPLTIILSHVEVLMDPSLNGQKRlPQYLQTIKNNTQRVLHLTEEMKRVSEVD-NPdfTLDIE 320
Cdd:PRK11006 199 QLEGARRNFFANVSHELRTPLTVLQGYLEMMQDQPLEGALR-EKALHTMREQTQRMEGLVKQLLTLSKIEaAP--TIDLN 275
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267689820 321 GVIPIEMLPEMLEEFKKWAEDEEIKFTYSLNRKPG-EGNSEfaldpkRLHQILTNLISNSIRFTPVNGSIDVQVQIEKDM 399
Cdd:PRK11006 276 EKVDVPMMLRVLEREAQTLSQGKHTITFEVDNSLKvFGNED------QLRSAISNLVYNAVNHTPEGTHITVRWQRVPQG 349
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1267689820 400 MSFSICDTGKGFDTKDLPFLFSKFYQGDPSRNDQL-HHGLGLYIVKELVIKHGGEIHARNNEPQGACIEFTI 470
Cdd:PRK11006 350 AEFSVEDNGPGIAPEHIPRLTERFYRVDKARSRQTgGSGLGLAIVKHALSHHDSRLEIESEVGKGTRFSFVL 421
|
|
| envZ |
PRK09467 |
osmolarity sensor protein; Provisional |
170-470 |
8.12e-21 |
|
osmolarity sensor protein; Provisional
Pssm-ID: 236531 [Multi-domain] Cd Length: 435 Bit Score: 94.59 E-value: 8.12e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267689820 170 FLFLTLYSYV-----------FARRfgkeLNKPIKELSAASQKIKNQDLDFEIKYESENEIGVLIDSFNSMKEELKtsly 238
Cdd:PRK09467 152 FSPLFRYTLAigllsvaggwlFIRI----QNRPLVALEHAALQVGKGEIPPPLREYGASEVRSVTRAFNQMAAGIK---- 223
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267689820 239 lqwKLEQERRDMVASIAHDLRTPLTIILSHVEvLMDPSlngqkrlPQYL-QTIKNNTQRV----------LHLTEEMKRV 307
Cdd:PRK09467 224 ---QLEDDRTLLMAGVSHDLRTPLTRIRLATE-MMSEE-------DGYLaESINKDIEECnaiieqfidyLRTGQEMPME 292
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267689820 308 SEvdnpDFTLDIEGVIPIEMlpemleefkkwAEDEEIKFTYSLNRKPGEGNsefALDPKRlhqILTNLISNSIRFTpvNG 387
Cdd:PRK09467 293 MA----DLNALLGEVIAAES-----------GYEREIETALQPGPIEVPMN---PIAIKR---ALANLVVNAARYG--NG 349
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267689820 388 SIDVQVQIEKDMMSFSICDTGKGFDTKDLPFLFSKFYQGDPSRNdQLHHGLGLYIVKELVIKHGGEIHARNNEPQGACIE 467
Cdd:PRK09467 350 WIKVSSGTEGKRAWFQVEDDGPGIPPEQLKHLFQPFTRGDSARG-SSGTGLGLAIVKRIVDQHNGKVELGNSEEGGLSAR 428
|
...
gi 1267689820 468 FTI 470
Cdd:PRK09467 429 AWL 431
|
|
| NtrB |
COG3852 |
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms]; |
240-471 |
2.05e-20 |
|
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
Pssm-ID: 443061 [Multi-domain] Cd Length: 361 Bit Score: 92.22 E-value: 2.05e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267689820 240 QWKLEQERR---------DMVASIAHDLRTPLTIILSHVEVLMDpSLNGQKrLPQYLQTIKNNTQRVLHLTEEMKRVSEV 310
Cdd:COG3852 119 RKRLERELRraeklaavgELAAGLAHEIRNPLTGIRGAAQLLER-ELPDDE-LREYTQLIIEEADRLNNLVDRLLSFSRP 196
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267689820 311 DNPDFT-LDIEGVIpIEMLPEMLEEFKKwaedeEIKFTYSLNrkpgEGNSEFALDPKRLHQILTNLISNSIRFTPVNGSI 389
Cdd:COG3852 197 RPPEREpVNLHEVL-ERVLELLRAEAPK-----NIRIVRDYD----PSLPEVLGDPDQLIQVLLNLVRNAAEAMPEGGTI 266
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267689820 390 DVQVQIE----------KDMMSFSICDTGKGFDTKDLPFLFSKFYQGDPSrndqlHHGLGLYIVKELVIKHGGEIHARNN 459
Cdd:COG3852 267 TIRTRVErqvtlgglrpRLYVRIEVIDNGPGIPEEILDRIFEPFFTTKEK-----GTGLGLAIVQKIVEQHGGTIEVESE 341
|
250
....*....|..
gi 1267689820 460 EPQGACieFTIS 471
Cdd:COG3852 342 PGKGTT--FRIY 351
|
|
| PRK10490 |
PRK10490 |
sensor protein KdpD; Provisional |
244-470 |
9.94e-20 |
|
sensor protein KdpD; Provisional
Pssm-ID: 236701 [Multi-domain] Cd Length: 895 Bit Score: 92.41 E-value: 9.94e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267689820 244 EQERRDMVASIAHDLRTPLTIILSHVEVLM-DPSLNGQKRLPQ---YLQTIKNNTQRVLHLTEeMKRVSevdNPDFTLDi 319
Cdd:PRK10490 661 EQLRNALLAALSHDLRTPLTVLFGQAEILTlDLASEGSPHARQaseIRQQVLNTTRLVNNLLD-MARIQ---SGGFNLR- 735
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267689820 320 egvipiemlpemleefKKWAEDEEI------KFTYSLNRKPGEGN--SEFAL---DPKRLHQILTNLISNSIRFTPVNGS 388
Cdd:PRK10490 736 ----------------KEWLTLEEVvgsalqMLEPGLSGHPINLSlpEPLTLihvDGPLFERVLINLLENAVKYAGAQAE 799
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267689820 389 IDVQVQIEKDMMSFSICDTGKGFDTKDLPFLFSKFYQGD-----PSRndqlhhGLGLYIVKELVIKHGGEIHARNNEPQG 463
Cdd:PRK10490 800 IGIDAHVEGERLQLDVWDNGPGIPPGQEQLIFDKFARGNkesaiPGV------GLGLAICRAIVEVHGGTIWAENRPEGG 873
|
....*..
gi 1267689820 464 ACIEFTI 470
Cdd:PRK10490 874 ACFRVTL 880
|
|
| PRK15347 |
PRK15347 |
two component system sensor kinase; |
252-468 |
1.69e-19 |
|
two component system sensor kinase;
Pssm-ID: 237951 [Multi-domain] Cd Length: 921 Bit Score: 92.01 E-value: 1.69e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267689820 252 ASIAHDLRTPLTIILSHVEVLMDPSLNGQKRlpQYLQTIKNNTQRVLHLTEEMKRVSEVDNPDFTLDIEGVIPIEMLPEM 331
Cdd:PRK15347 403 TTISHEIRTPLNGVLGALELLQNTPLTAEQM--DLADTARQCTLSLLAIINNLLDFSRIESGQMTLSLEETALLPLLDQA 480
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267689820 332 LEEFKKWAEDEEIKFTYSLNRKPGEgnsEFALDPKRLHQILTNLISNSIRFTPvNGSIDVQVQIEKDMMSFSICDTGKGF 411
Cdd:PRK15347 481 MLTIQGPAQSKSLTLRTFVGAHVPL---YLHLDSLRLRQILVNLLGNAVKFTE-TGGIRLRVKRHEQQLCFTVEDTGCGI 556
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1267689820 412 DTKDLPFLFSKFYQGDpsrndqlHH----GLGLYIVKELVIKHGGEIHARNNEPQGACIEF 468
Cdd:PRK15347 557 DIQQQQQIFTPFYQAD-------THsqgtGLGLTIASSLAKMMGGELTLFSTPGVGSCFSL 610
|
|
| HATPase_BaeS-like |
cd16946 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
364-456 |
9.90e-19 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.
Pssm-ID: 340422 [Multi-domain] Cd Length: 109 Bit Score: 81.36 E-value: 9.90e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267689820 364 DPKRLHQILTNLISNSIRFTPVNGSIDVQVQIEKDMMSFSICDTGKGFDTKDLPFLFSKFYQGDPSRNDQL-HHGLGLYI 442
Cdd:cd16946 1 DRDRLQQLFVNLLENSLRYTDTGGKLRIRAAQTPQEVRLDVEDSAPGVSDDQLARLFERFYRVESSRNRASgGSGLGLAI 80
|
90
....*....|....
gi 1267689820 443 VKELVIKHGGEIHA 456
Cdd:cd16946 81 CHNIALAHGGTISA 94
|
|
| PRK10604 |
PRK10604 |
sensor protein RstB; Provisional |
148-468 |
1.81e-18 |
|
sensor protein RstB; Provisional
Pssm-ID: 236724 [Multi-domain] Cd Length: 433 Bit Score: 87.35 E-value: 1.81e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267689820 148 YVLASSIDYYIKYI----FLIILLIPFLFLTLYSYVF--ARRFGKELNKpikeLSAASQKIKNQDLDFEIKYESENEIGV 221
Cdd:PRK10604 118 YVLAVGPVPYLYYLhqmrLLDIALLALIGLSLAFPVFlwMRPHWQDMLK----LEAAAQRLGDGHLAERIHFDEGSSLER 193
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267689820 222 LIDSFNSMKEELKTslylqwkLEQERRDMVASIAHDLRTPLTIILSHVEVLMDPSLNGQkrlpqylQTIKNNTQRVLHLT 301
Cdd:PRK10604 194 LGVAFNQMADNINA-------LIASKKQLIDGIAHELRTPLVRLRYRLEMSDNLSAAES-------QALNRDIGQLEALI 259
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267689820 302 EEMKRVSEVDNPDFTLDIEGVIPIEMLPEMLEEFKKWAEDEEIKFTyslnrKPGEGNSeFALDPKRLHQILTNLISNSIR 381
Cdd:PRK10604 260 EELLTYARLDRPQNELHLSEPDLPAWLSTHLADIQAVTPEKTVRLD-----TPHQGDY-GALDMRLMERVLDNLLNNALR 333
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267689820 382 FTpvNGSIDVQVQIEKDMMSFSICDTGKGFDTKDLPFLFSKFYQGDPSRNDQLH-HGLGLYIVKELVIKHGGEIHARNNE 460
Cdd:PRK10604 334 YA--HSRVRVSLLLDGNQACLIVEDDGPGIPPEERERVFEPFVRLDPSRDRATGgCGLGLAIVHSIALAMGGSVNCDESE 411
|
....*...
gi 1267689820 461 PQGACIEF 468
Cdd:PRK10604 412 LGGARFSF 419
|
|
| PRK11091 |
PRK11091 |
aerobic respiration control sensor protein ArcB; Provisional |
240-471 |
2.54e-17 |
|
aerobic respiration control sensor protein ArcB; Provisional
Pssm-ID: 236842 [Multi-domain] Cd Length: 779 Bit Score: 84.99 E-value: 2.54e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267689820 240 QWKLEQERRD---MVASIAHDLRTPLTII--LSHVevLMDPSLNGQKRlpQYLQTIK-------NNTQRVLHLTEEMKRV 307
Cdd:PRK11091 273 QDALEKASRDkttFISTISHELRTPLNGIvgLSRI--LLDTELTAEQR--KYLKTIHvsaitlgNIFNDIIDMDKMERRK 348
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267689820 308 SEVDN-----PDFTLDIEGVIPIEmlpemleefkkwAEDEEIKFTYSLNrkpGEGNSEFALDPKRLHQILTNLISNSIRF 382
Cdd:PRK11091 349 LQLDNqpidfTDFLADLENLSGLQ------------AEQKGLRFDLEPL---LPLPHKVITDGTRLRQILWNLISNAVKF 413
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267689820 383 TPvNGSIDVQVQIE-KDMMSFSICDTGKGFDTKDLPFLFSKFYQGdPSRNDQLH---HGLGLYIVKELVIKHGGEIHARN 458
Cdd:PRK11091 414 TQ-QGGVTVRVRYEeGDMLTFEVEDSGIGIPEDELDKIFAMYYQV-KDSHGGKPatgTGIGLAVSKRLAQAMGGDITVTS 491
|
250
....*....|...
gi 1267689820 459 NEPQGACieFTIS 471
Cdd:PRK11091 492 EEGKGSC--FTLT 502
|
|
| PRK11107 |
PRK11107 |
hybrid sensory histidine kinase BarA; Provisional |
364-471 |
1.36e-16 |
|
hybrid sensory histidine kinase BarA; Provisional
Pssm-ID: 236848 [Multi-domain] Cd Length: 919 Bit Score: 82.59 E-value: 1.36e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267689820 364 DPKRLHQILTNLISNSIRFTPvNGSIDVQVQ---IEKDMMS--FSICDTGKGFDTKDLPFLFSKFYQGDPS---Rndqlh 435
Cdd:PRK11107 405 DPLRLQQIITNLVGNAIKFTE-SGNIDILVElraLSNTKVQleVQIRDTGIGISERQQSQLFQAFRQADASisrR----- 478
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 1267689820 436 H---GLGLYIVKELVIKHGGEI--HARNNepQGACIEFTIS 471
Cdd:PRK11107 479 HggtGLGLVITQKLVNEMGGDIsfHSQPN--RGSTFWFHLP 517
|
|
| HATPase_CpxA-like |
cd16949 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
368-470 |
5.33e-16 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.
Pssm-ID: 340425 [Multi-domain] Cd Length: 104 Bit Score: 73.51 E-value: 5.33e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267689820 368 LHQILTNLISNSIRFTPvnGSIDVQVQIEKDMMSFSICDTGKGFDTKDLPFLFSKFYQGDPSRN-DQLHHGLGLYIVKEL 446
Cdd:cd16949 1 LARALENVLRNALRYSP--SKILLDISQDGDQWTITITDDGPGVPEDQLEQIFLPFYRVDSARDrESGGTGLGLAIAERA 78
|
90 100
....*....|....*....|....
gi 1267689820 447 VIKHGGEIHARNNEPQGACIEFTI 470
Cdd:cd16949 79 IEQHGGKIKASNRKPGGLRVRIWL 102
|
|
| COG4192 |
COG4192 |
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ... |
101-469 |
2.74e-15 |
|
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];
Pssm-ID: 443346 [Multi-domain] Cd Length: 640 Bit Score: 78.19 E-value: 2.74e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267689820 101 GTLDDQLIENNKSIYEKVNRSDQKGKVITKYLPILDK---NRMEGVLAVRYVLASSIDYYiKYIFLIILLIPFLFLTLYS 177
Cdd:COG4192 265 GGLPSLRRDELAAQATLEALAEENNSILEQLRTQISGlvgNSREQLVALNQETAQLVQQS-GILLLAIALLSLLLAVLIN 343
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267689820 178 YVFA-RRFGKELNKpikeLSAASQKIKNQDLDFEIKYESENEIG-------VLIDSFNSMKEELKTSLYLQWKLEQERRD 249
Cdd:COG4192 344 YFYVrRRLVKRLNA----LSDAMAAIAAGDLDVPIPVDGNDEIGriarllrVFRDQAIEKTQELETEIEERKRIEKNLRQ 419
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267689820 250 M----------------VASIAHDLRTPLTIILSHVEVL-MDPSLNGQKRLPQYLQTIKNNTQRVLHLTEEMKRVS-EVD 311
Cdd:COG4192 420 TqdeliqaakmavvgqtMTSLAHELNQPLNAMSMYLFSAkKALEQENYAQLPTSLDKIEGLIERMDKIIKSLRQFSrKSD 499
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267689820 312 NPDFTLDIEGVIPIEMlpEMLEEFKKwaeDEEIKFTYslnrkPGEGNseFALDPKRLHQILTNLISNSIRFTPVNGSIDV 391
Cdd:COG4192 500 TPLQPVDLRQVIEQAW--ELVESRAK---PQQITLHI-----PDDLM--VQGDQVLLEQVLVNLLVNALDAVATQPQISV 567
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267689820 392 QVQIEKDMMSFSICDTGKGFDtkDLPFLFSKFYQgdpsrNDQLHHGLGLYIVKELVIKHGGEIHARNNEPQGACI--EFT 469
Cdd:COG4192 568 DLLSNAENLRVAISDNGNGWP--LVDKLFTPFTT-----TKEVGLGLGLSICRSIMQQFGGDLYLASTLERGAMVilEFN 640
|
|
| HATPase_EnvZ-like |
cd16950 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
368-466 |
8.60e-15 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.
Pssm-ID: 340426 [Multi-domain] Cd Length: 101 Bit Score: 70.17 E-value: 8.60e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267689820 368 LHQILTNLISNSIRFTpvNGSIDVQVQIEKDMMSFSICDTGKGFDTKDLPFLFSKFYQGDPSRnDQLHHGLGLYIVKELV 447
Cdd:cd16950 1 LKRVLSNLVDNALRYG--GGWVEVSSDGEGNRTRIQVLDNGPGIAPEEVDELFQPFYRGDNAR-GTSGTGLGLAIVQRIS 77
|
90
....*....|....*....
gi 1267689820 448 IKHGGEIHARNNEPQGACI 466
Cdd:cd16950 78 DAHGGSLTLANRAGGGLCA 96
|
|
| HATPase_BvrS-ChvG-like |
cd16953 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
368-470 |
9.35e-15 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.
Pssm-ID: 340429 [Multi-domain] Cd Length: 110 Bit Score: 70.29 E-value: 9.35e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267689820 368 LHQILTNLISNSIRFTP-VNGSIDVQVQIEKDMMSFSICDTGKGFDTKDLPFLFSKFYQGDP-SRNDQLHHGLGLYIVKE 445
Cdd:cd16953 1 LGQVLRNLIGNAISFSPpDTGRITVSAMPTGKMVTISVEDEGPGIPQEKLESIFDRFYTERPaNEAFGQHSGLGLSISRQ 80
|
90 100
....*....|....*....|....*....
gi 1267689820 446 LVIKHGGEIHARNNEP----QGACieFTI 470
Cdd:cd16953 81 IIEAHGGISVAENHNQpgqvIGAR--FTV 107
|
|
| HAMP |
COG2770 |
HAMP domain [Signal transduction mechanisms]; |
131-274 |
1.48e-14 |
|
HAMP domain [Signal transduction mechanisms];
Pssm-ID: 442051 [Multi-domain] Cd Length: 631 Bit Score: 76.31 E-value: 1.48e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267689820 131 YLPILDKNRMEGVLAVRYVLASSIDYYIKYIFLIILLIPFLFLTLYSYVFARRfgkeLNKPIKELSAASQKIKNQDLDFE 210
Cdd:COG2770 183 IAALLAALLLLLLGGLLLVVLLEAALAALLLLLLLALLALLLALLLALLLARR----ITRPLRRLAEAARRIAAGDLDVR 258
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1267689820 211 IKYESENEIGVLIDSFNSMKEELKTSLYLQWKLEQERRDMVASIAHDLRTPLTIILSHVEVLMD 274
Cdd:COG2770 259 IPVSRKDEIGELARAFNRMADSLRESIEEAEEEEELAEAELARLLEALLELLLALLLLLLALLL 322
|
|
| HATPase_BceS-YxdK-YvcQ-like |
cd16948 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
364-471 |
2.16e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.
Pssm-ID: 340424 [Multi-domain] Cd Length: 109 Bit Score: 69.24 E-value: 2.16e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267689820 364 DPKRLHQILTNLISNSIRFTPVNGSIDVQVQIEKDMMSFSICDTGKGFDTKDLPFLFSKFYQGDPSRNDQLHHGLGLYIV 443
Cdd:cd16948 2 DAKWLSFIIGQIVSNALKYSKQGGKIEIYSETNEQGVVLSIKDFGIGIPEEDLPRVFDKGFTGENGRNFQESTGMGLYLV 81
|
90 100
....*....|....*....|....*...
gi 1267689820 444 KELVIKHGGEIHARNNEPQGAciEFTIS 471
Cdd:cd16948 82 KKLCDKLGHKIDVESEVGEGT--TFTIT 107
|
|
| KinC |
COG5807 |
Sporulation sensor histidine kinase C [Cell cycle control, cell division, chromosome ... |
206-471 |
2.67e-14 |
|
Sporulation sensor histidine kinase C [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444509 [Multi-domain] Cd Length: 358 Bit Score: 74.05 E-value: 2.67e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267689820 206 DLDFEIKYESENEIG-VLIDSFNSMKEELKTSLYLQWKLEQERRdMVASIAHDLRTPLTIILSHVEVLMDPSlnGQKRLP 284
Cdd:COG5807 106 EIIYPIYYKDGVILGlITVYRDITKRKEAEDKLLRSEKLSVAGE-LAAGIAHEIRNPLTSIKGFLQLLQESR--EDSERE 182
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267689820 285 QYLQTIKNNTQRVLHLTEEMKRVSevdNPDfTLDIEGVIPIEMLPEMLEEFKKWAEDEEIKFTYSLNrkpgEGNSEFALD 364
Cdd:COG5807 183 EYFNIIISEIDRINTIITELLVLS---KPK-KFNFKKLNLNDVLEDVIALLSTEAILKNISIKYDLA----DDEPVINGD 254
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267689820 365 PKRLHQILTNLISNSIRFTPVNGSIDVQVQIEKDMMSFSICDTGKGFDTKDLPFLFSKFYQgdpsrNDQLHHGLGLYIVK 444
Cdd:COG5807 255 KNQLKQVFINLIKNAIEAMETGGNITIKTYVEGDFVVISVKDEGIGIPEEVLEKIGEPFFT-----TKEEGTGLGLSICK 329
|
250 260
....*....|....*....|....*..
gi 1267689820 445 ELVIKHGGEIHARNNEPQGAciEFTIS 471
Cdd:COG5807 330 KIIEEHNGTIEVESKPGKGT--TFTIY 354
|
|
| PRK11466 |
PRK11466 |
hybrid sensory histidine kinase TorS; Provisional |
165-465 |
4.89e-14 |
|
hybrid sensory histidine kinase TorS; Provisional
Pssm-ID: 236914 [Multi-domain] Cd Length: 914 Bit Score: 74.56 E-value: 4.89e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267689820 165 ILLIPFLFLTLYSYVFARRFGKELNKPIKELSAASQKIKNQDLDF---EIKYESE-NEIGVLIDSF-------NSMKEEL 233
Cdd:PRK11466 333 LLLLGMVSLCALILILWRVVYRSVTRPLAEQTQALQRLLDGDIDSpfpETAGVRElDTIGRLMDAFrsnvhalNRHREQL 412
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267689820 234 KTSL-------------YLQWKLEQERRD-----MVASIAHDLRTPLTIILSHVEVLMDPSLNGQKRlpQYLQTIKNNTQ 295
Cdd:PRK11466 413 AAQVkartaelqelvieHRQARAEAEKASqaksaFLAAMSHEIRTPLYGILGTAQLLADNPALNAQR--DDLRAITDSGE 490
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267689820 296 RVLHLTEEMKRVS--EVDNPDFTLDIEGVIPIEMLPEMLEEFKKWAEDEEIKFTYSLNRK-PgegnSEFALDPKRLHQIL 372
Cdd:PRK11466 491 SLLTILNDILDYSaiEAGGKNVSVSDEPFEPRPLLESTLQLMSGRVKGRPIRLATDIADDlP----TALMGDPRRIRQVI 566
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267689820 373 TNLISNSIRFTPvNGSIDVQVQIEKDMMSFSICDTGKGFDTKDLPFLFSKFYQGDPSRNDQlhhGLGLYIVKELVIKHGG 452
Cdd:PRK11466 567 TNLLSNALRFTD-EGSIVLRSRTDGEQWLVEVEDSGCGIDPAKLAEIFQPFVQVSGKRGGT---GLGLTISSRLAQAMGG 642
|
330
....*....|...
gi 1267689820 453 EIHARNNEPQGAC 465
Cdd:PRK11466 643 ELSATSTPEVGSC 655
|
|
| PRK11360 |
PRK11360 |
two-component system sensor histidine kinase AtoS; |
194-470 |
8.76e-14 |
|
two-component system sensor histidine kinase AtoS;
Pssm-ID: 236901 [Multi-domain] Cd Length: 607 Bit Score: 73.46 E-value: 8.76e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267689820 194 ELSAASQKIKNQDldfeikyesENEIGVLIdSFNSMKEELKTSLYLQwklEQERR----DMVASIAHDLRTPLTIILSHV 269
Cdd:PRK11360 346 ELSVSTSLLHNTH---------GEMIGALV-IFSDLTERKRLQRRVA---RQERLaalgELVAGVAHEIRNPLTAIRGYV 412
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267689820 270 EVLMDPSLNgqKRLPQYLQTIKNNTQRVLHLTEEM---KRVSEVDNPDFTLDiegvipiEMLPEMLEEFKKWAEDEEIKF 346
Cdd:PRK11360 413 QIWRQQTSD--PPSQEYLSVVLREVDRLNKVIDQLlefSRPRESQWQPVSLN-------ALVEEVLQLFQTAGVQARVDF 483
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267689820 347 TYSLNrkpgEGNSEFALDPKRLHQILTNLISNSIRFTPVNGSIDVQVQIEKD-MMSFSICDTGKGFDTKDLPFLFSKFYQ 425
Cdd:PRK11360 484 ETELD----NELPPIWADPELLKQVLLNILINAVQAISARGKIRIRTWQYSDgQVAVSIEDNGCGIDPELLKKIFDPFFT 559
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 1267689820 426 GDPSRNdqlhhGLGLYIVKELVIKHGGEIHARNNEPQGACieFTI 470
Cdd:PRK11360 560 TKAKGT-----GLGLALSQRIINAHGGDIEVESEPGVGTT--FTL 597
|
|
| PRK10364 |
PRK10364 |
two-component system sensor histidine kinase ZraS; |
343-470 |
1.53e-13 |
|
two-component system sensor histidine kinase ZraS;
Pssm-ID: 236674 [Multi-domain] Cd Length: 457 Bit Score: 72.51 E-value: 1.53e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267689820 343 EIKFTyslnrkPGEGNSEFALDPKRLHQILTNLISNSIRFTPVNGSIDVQVQIEKDMMSFSICDTGKGFDTKDLPFLFSK 422
Cdd:PRK10364 330 QLRFT------ANDTLPEIQADPDRLTQVLLNLYLNAIQAIGQHGVISVTASESGAGVKISVTDSGKGIAADQLEAIFTP 403
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 1267689820 423 FYQgdpSRNDQLhhGLGLYIVKELVIKHGGEIHARNNEPQGAciEFTI 470
Cdd:PRK10364 404 YFT---TKAEGT--GLGLAVVHNIVEQHGGTIQVASQEGKGA--TFTL 444
|
|
| HATPase_EcPhoR-like |
cd16952 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
368-472 |
2.23e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.
Pssm-ID: 340428 [Multi-domain] Cd Length: 108 Bit Score: 66.07 E-value: 2.23e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267689820 368 LHQILTNLISNSIRFTPVNGSIDVQVQIEKDMMSFSICDTGKGFDTKDLPFLFSKFYQGDPSRNDQLH-HGLGLYIVKEL 446
Cdd:cd16952 1 LRSAFSNLVSNAVKYTPPSDTITVRWSQEESGARLSVEDTGPGIPPEHIPRLTERFYRVDIERCRNTGgTGLGLAIVKHV 80
|
90 100
....*....|....*....|....*.
gi 1267689820 447 VIKHGGEIHARNNEPQGACIEFTISS 472
Cdd:cd16952 81 MSRHDARLLIASELGKGSRFTCLFPS 106
|
|
| HATPase_BasS-like |
cd16940 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
364-463 |
2.81e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.
Pssm-ID: 340417 [Multi-domain] Cd Length: 113 Bit Score: 65.89 E-value: 2.81e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267689820 364 DPKRLHQILTNLISNSIRFTPVNGSIDVQVQiEKDMMSFSICDTGKGFDTKDLPFLFSKFYQGDPSRNDQLhhGLGLYIV 443
Cdd:cd16940 10 DALLLFLLLRNLVDNAVRYSPQGSRVEIKLS-ADDGAVIRVEDNGPGIDEEELEALFERFYRSDGQNYGGS--GLGLSIV 86
|
90 100
....*....|....*....|
gi 1267689820 444 KELVIKHGGEIHARNNEPQG 463
Cdd:cd16940 87 KRIVELHGGQIFLGNAQGGG 106
|
|
| PRK09303 |
PRK09303 |
histidine kinase; |
239-470 |
2.84e-13 |
|
histidine kinase;
Pssm-ID: 236462 [Multi-domain] Cd Length: 380 Bit Score: 71.14 E-value: 2.84e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267689820 239 LQWKLE-QERrdMVASIAHDLRTPLTIILSHVEVLmdpSLNGQKRLPQYLQTIKNNTQRVLH-LTEEMKRVS----EVD- 311
Cdd:PRK09303 144 LLEQLKfKDR--VLAMLAHDLRTPLTAASLALETL---ELGQIDEDTELKPALIEQLQDQARrQLEEIERLItdllEVGr 218
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267689820 312 NPDFTLDIEgviPIEM-LP----EMLEEFKKWAEDEEIKFTYSLnrkPGEGNSEFAlDPKRLHQILTNLISNSIRFTPVN 386
Cdd:PRK09303 219 TRWEALRFN---PQKLdLGslcqEVILELEKRWLAKSLEIQTDI---PSDLPSVYA-DQERIRQVLLNLLDNAIKYTPEG 291
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267689820 387 GSIDV--------QVQIekdmmsfSICDTGKGFDTKDLPFLFSKFYQGDPSRnDQLHHGLGLYIVKELVIKHGGEIHARN 458
Cdd:PRK09303 292 GTITLsmlhrttqKVQV-------SICDTGPGIPEEEQERIFEDRVRLPRDE-GTEGYGIGLSVCRRIVRVHYGQIWVDS 363
|
250
....*....|..
gi 1267689820 459 NEPQGACIEFTI 470
Cdd:PRK09303 364 EPGQGSCFHFTL 375
|
|
| HATPase_FilI-like |
cd16921 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
368-470 |
4.21e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340398 [Multi-domain] Cd Length: 105 Bit Score: 65.43 E-value: 4.21e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267689820 368 LHQILTNLISNSIRFT--PVNGSIDVQVQIEKDMMSFSICDTGKGFDTKDLPFLFSKFYQGDPsRNDQLHHGLGLYIVKE 445
Cdd:cd16921 1 LGQVLTNLLGNAIKFRrpRRPPRIEVGAEDVGEEWTFYVRDNGIGIDPEYAEKVFGIFQRLHS-REEYEGTGVGLAIVRK 79
|
90 100
....*....|....*....|....*
gi 1267689820 446 LVIKHGGEIHARNNEPQGACIEFTI 470
Cdd:cd16921 80 IIERHGGRIWLESEPGEGTTFYFTL 104
|
|
| PRK09959 |
PRK09959 |
acid-sensing system histidine kinase EvgS; |
247-470 |
4.32e-13 |
|
acid-sensing system histidine kinase EvgS;
Pssm-ID: 182169 [Multi-domain] Cd Length: 1197 Bit Score: 71.69 E-value: 4.32e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267689820 247 RRDMVASIAHDLRTPLTIILSHVEVLMDPSLNGQKRLpQYLQTIKNNTQRVLHLTEEMKRVSEVDNPDFTLDIEGVIPIE 326
Cdd:PRK09959 712 KSQFLATMSHEIRTPISSIMGFLELLSGSGLSKEQRV-EAISLAYATGQSLLGLIGEILDVDKIESGNYQLQPQWVDIPT 790
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267689820 327 MLPEMLEEFKKWAEDEEIKFTYSlnrKPGEGNSEFALDPKRLHQILTNLISNSIRFTpVNGSIDVQ---VQIEKD--MMS 401
Cdd:PRK09959 791 LVQNTCHSFGAIAASKSIALSCS---STFPDHYLVKIDPQAFKQVLSNLLSNALKFT-TEGAVKITtslGHIDDNhaVIK 866
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1267689820 402 FSICDTGKGFDTKDLPFLFSKFYQGDPSRNdQLHHGLGLYIVKELVIKHGGEIHARNNEPQGACIEFTI 470
Cdd:PRK09959 867 MTIMDSGSGLSQEEQQQLFKRYSQTSAGRQ-QTGSGLGLMICKELIKNMQGDLSLESHPGIGTTFTITI 934
|
|
| HisKA |
pfam00512 |
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ... |
246-313 |
4.38e-13 |
|
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.
Pssm-ID: 459839 [Multi-domain] Cd Length: 66 Bit Score: 64.15 E-value: 4.38e-13
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1267689820 246 ERRDMVASIAHDLRTPLTIILSHVEVLMDPSLNGQKRlpQYLQTIKNNTQRVLHLTEEMKRVSEVDNP 313
Cdd:pfam00512 1 AKSEFLANLSHELRTPLTAIRGYLELLRDEKLDEEQR--EYLETILRSAERLLRLINDLLDLSRIEAG 66
|
|
| CitA |
COG3290 |
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ... |
239-470 |
4.99e-13 |
|
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];
Pssm-ID: 442519 [Multi-domain] Cd Length: 389 Bit Score: 70.26 E-value: 4.99e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267689820 239 LQWKLEQERR--DMVASIAHDLRTPLTIILSHVEvlmdpsLNGQKRLPQYLQTIKNNTQRVLHlteemKRVSEVDNPDft 316
Cdd:COG3290 179 LEEELEGVKElaEALRAQRHDFRNHLHTISGLLQ------LGEYDEALEYIDEISEELQELID-----SLLSRIGNPV-- 245
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267689820 317 ldIEGVipiemlpemLEEFKKWAEDEEIKFTYSLNRKPgegnSEFALDPKRLHQILTNLISNSI----RFTPVNGSIDVQ 392
Cdd:COG3290 246 --LAAL---------LLGKAARARERGIDLTIDIDSDL----PDLPLSDTDLVTILGNLLDNAIeaveKLPEEERRVELS 310
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1267689820 393 VQIEKDMMSFSICDTGKGFDTKDLPFLFSKfyqGDPSRNDQlHHGLGLYIVKELVIKHGGEIHARNNEPQGACIEFTI 470
Cdd:COG3290 311 IRDDGDELVIEVEDSGPGIPEELLEKIFER---GFSTKLGE-GRGLGLALVKQIVEKYGGTIEVESEEGEGTVFTVRL 384
|
|
| YesM |
COG2972 |
Sensor histidine kinase YesM [Signal transduction mechanisms]; |
7-470 |
6.44e-13 |
|
Sensor histidine kinase YesM [Signal transduction mechanisms];
Pssm-ID: 442211 [Multi-domain] Cd Length: 445 Bit Score: 70.43 E-value: 6.44e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267689820 7 LKNQFILTFASVIFLSLISTICSLVLLYYFLSVYNEKSVQPANYYEKKVPSIEKFVELKGEKILEVSFQKNLEKVIPMEG 86
Cdd:COG2972 2 SKSLSLLSIVLLLLILLLLVLLILLLSLLLIILLLLLLLILLLLLLILLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267689820 87 ITYQVINLRGNKIYGTLDDQLIENNKSIYEKVNRSDQKGKVITKYLPILDkNRMEGVLAVRYVLASSIDYYIKYIFLIIL 166
Cdd:COG2972 82 ILLLLLLLLLLLILLLSLLLLLALILLLALLLLLSILLLILGLLLIILLL-LSLLGWTLVSLIPKSELFRGLFSLRRLIL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267689820 167 LIpFLFLTLYSYVFARRFGKELNKPIKELSAASQKIKNQDLdFEIKYESENEIGVLIDSFNSMKEELKTSLYLQWKLEQE 246
Cdd:COG2972 161 LI-ILLLLLLALLLSYLLSRSITRPIKRLKKAMKKVEKGDL-VRLEVSGNDEIGILARSFNEMVERIKELIEEVYELELE 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267689820 247 RRDMVASI------AHDLRTPLTIILSHVEvlmdpsLNGQKRLPQYLQtiknntqrvlHLTEEMKRVSEVDNPDFTLDIE 320
Cdd:COG2972 239 KKEAELKAlqaqinPHFLFNTLNSIRWLAE------LEDPEEAEEMLE----------ALSKLLRYSLSKGDELVTLEEE 302
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267689820 321 gvipIEMLPEMLEEFKKWAEDeeiKFTYSLNRKPGEGNsefALDPKRLHQILT-NLISNSIRFTPVNGSIDVQVQIEKDM 399
Cdd:COG2972 303 ----LELIKSYLEIQKLRFGD---RLEVEIEIDEELLD---LLIPKLILQPLVeNAIEHGIEPKEGGGTIRISIRKEGDR 372
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1267689820 400 MSFSICDTGKGFDTKDLPFLFSKFYQGDPsrndqlHHGLGLYIVKELVIKHGGE---IHARNNEPQGACIEFTI 470
Cdd:COG2972 373 LVITVEDNGVGMPEEKLEKLLEELSSKGE------GRGIGLRNVRERLKLYYGEeygLEIESEPGEGTTVTIRI 440
|
|
| HisKA |
smart00388 |
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ... |
246-313 |
9.04e-13 |
|
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.
Pssm-ID: 214644 [Multi-domain] Cd Length: 66 Bit Score: 62.97 E-value: 9.04e-13
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1267689820 246 ERRDMVASIAHDLRTPLTIILSHVEVLMDPSLNGQKRlpQYLQTIKNNTQRVLHLTEEMKRVSEVDNP 313
Cdd:smart00388 1 AKREFLANLSHELRTPLTAIRGYLELLLDTELSEEQR--EYLETILREAERLLRLINDLLDLSRIEAG 66
|
|
| HATPase_CreC-like |
cd16945 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
364-458 |
1.03e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.
Pssm-ID: 340421 [Multi-domain] Cd Length: 106 Bit Score: 64.40 E-value: 1.03e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267689820 364 DPKRLHQILTNLISNSIRFTPVNGSIDVQVQIEKDMMSFSICDTGKGFDTKDLPFLFSKFYQGDPSRNDQLHHGLGLYIV 443
Cdd:cd16945 1 DPFLLRQAINNLLDNAIDFSPEGGLIALQLEADTEGIELLVFDEGSGIPDYALNRVFERFYSLPRPHSGQKSTGLGLAFV 80
|
90
....*....|....*
gi 1267689820 444 KELVIKHGGEIHARN 458
Cdd:cd16945 81 QEVAQLHGGRITLRN 95
|
|
| PRK10841 |
PRK10841 |
two-component system sensor histidine kinase RcsC; |
364-447 |
1.12e-12 |
|
two-component system sensor histidine kinase RcsC;
Pssm-ID: 182772 [Multi-domain] Cd Length: 924 Bit Score: 70.39 E-value: 1.12e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267689820 364 DPKRLHQILTNLISNSIRFTPVnGSIDVQVQIEKDMMSFSICDTGKGFDTKDLPFLFSKFYQGDPS--RNDQlHHGLGLY 441
Cdd:PRK10841 559 DPMRLQQVISNLLSNAIKFTDT-GCIVLHVRVDGDYLSFRVRDTGVGIPAKEVVRLFDPFFQVGTGvqRNFQ-GTGLGLA 636
|
....*.
gi 1267689820 442 IVKELV 447
Cdd:PRK10841 637 ICEKLI 642
|
|
| HisKA |
cd00082 |
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ... |
244-308 |
1.39e-12 |
|
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.
Pssm-ID: 119399 [Multi-domain] Cd Length: 65 Bit Score: 62.62 E-value: 1.39e-12
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1267689820 244 EQERRDMVASIAHDLRTPLTIILSHVEVLMDpSLNGQKRLPQYLQTIKNNTQRVLHLTEEMKRVS 308
Cdd:cd00082 1 LQAKGEFLANVSHELRTPLTAIRGALELLEE-ELLDDEEQREYLERIREEAERLLRLINDLLDLS 64
|
|
| HATPase_TutC-TodS-like |
cd16925 |
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ... |
364-464 |
3.81e-12 |
|
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.
Pssm-ID: 340402 [Multi-domain] Cd Length: 110 Bit Score: 62.90 E-value: 3.81e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267689820 364 DPKRLHQILTNLISNSIRFTPVNGSIDVQVQIEK-DMMSFSICDTGKGFDTKDLPFLFSKFYQGDPSRNDQLH-HGLGLY 441
Cdd:cd16925 1 DAEKYERVVLNLLSNAFKFTPDGGRIRCILEKFRlNRFLLTVSDSGPGIPPNLREEIFERFRQGDGSSTRAHGgTGLGLS 80
|
90 100
....*....|....*....|...
gi 1267689820 442 IVKELVIKHGGEIHARNNEPQGA 464
Cdd:cd16925 81 IVKEFVELHGGTVTVSDAPGGGA 103
|
|
| HATPase_VanS-like |
cd16923 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
368-457 |
7.73e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.
Pssm-ID: 340400 [Multi-domain] Cd Length: 102 Bit Score: 61.63 E-value: 7.73e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267689820 368 LHQILTNLISNSIRFTPVNGSIDVQVQIEKDMMSFSICDTGKGFDTKDLPFLFSKFYQGDPSRNDQlHHGLGLYIVKELV 447
Cdd:cd16923 1 LQRVFSNLLSNAIKYSPENTRIYITSFLTDDVVNIMFKNPSSHPLDFKLEKLFERFYRGDNSRNTE-GAGLGLSIAKAII 79
|
90
....*....|
gi 1267689820 448 IKHGGEIHAR 457
Cdd:cd16923 80 ELHGGSASAE 89
|
|
| KinE |
COG5809 |
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ... |
250-470 |
7.77e-12 |
|
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444511 [Multi-domain] Cd Length: 489 Bit Score: 67.31 E-value: 7.77e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267689820 250 MVASIAHDLRTPLTIILSHVEvLMDPSLNGQKRlpQYLQTIKNNTQRVLHLTEE--------MKRVSEVDNPDFtldIEG 321
Cdd:COG5809 273 LAAGIAHEIRNPLTSLKGFIQ-LLKDTIDEEQK--TYLDIMLSELDRIESIISEflvlakpqAIKYEPKDLNTL---IEE 346
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267689820 322 VIPIeMLPEMLEEfkkwaeDEEIKFTYSLNRKPGEGnsefalDPKRLHQILTNLISNSIRFTPVNGSIDVQVQI-EKDMM 400
Cdd:COG5809 347 VIPL-LQPQALLK------NVQIELELEDDIPDILG------DENQLKQVFINLLKNAIEAMPEGGNITIETKAeDDDKV 413
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1267689820 401 SFSICDTGKGFDTKDLPFLFSKFY----QGDpsrndqlhhGLGLYIVKELVIKHGGEIHARNNEPQGACIEFTI 470
Cdd:COG5809 414 VISVTDEGCGIPEERLKKLGEPFYttkeKGT---------GLGLMVSYKIIEEHGGKITVESEVGKGTTFSITL 478
|
|
| NarQ |
COG3850 |
Signal transduction histidine kinase NarQ, nitrate/nitrite-specific [Signal transduction ... |
139-268 |
1.92e-11 |
|
Signal transduction histidine kinase NarQ, nitrate/nitrite-specific [Signal transduction mechanisms];
Pssm-ID: 443059 [Multi-domain] Cd Length: 448 Bit Score: 66.06 E-value: 1.92e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267689820 139 RMEGVLAVRYVLASSIDYYIKYIFLIILLIPFLFLTLYSYVFARRFGKELNKPIKELSAASQKIKNQDLDFEIKYESENE 218
Cdd:COG3850 93 LLLLLLLLLLLLLLLLLLLAAAINRKLALLRLLLALLLALLLAYLLRRRIVRPLRRLTQAAERIARGDFDARVPVSGRDE 172
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 1267689820 219 IGVLIDSFNSMKEELKTslyLQWKLEQERRDMVASIAHDLRTPLTIILSH 268
Cdd:COG3850 173 LGTLARAFNRMADELQE---LYAELEEEEELEAELELLALLDELLLLAAL 219
|
|
| HATPase_AtoS-like |
cd16943 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
365-471 |
4.47e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.
Pssm-ID: 340419 [Multi-domain] Cd Length: 105 Bit Score: 59.74 E-value: 4.47e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267689820 365 PKRLHQILTNLISNSIRFTPVNGSIDVQVQIEKDMMSFSICDTGKGFDTKDLPFLFSKFYQGDPSRNDQlhhGLGLYIVK 444
Cdd:cd16943 1 PSQLNQVLLNLLVNAAQAMEGRGRITIRTWAHVDQVLIEVEDTGSGIDPEILGRIFDPFFTTKPVGEGT---GLGLSLSY 77
|
90 100
....*....|....*....|....*..
gi 1267689820 445 ELVIKHGGEIHARNNEPQGAciEFTIS 471
Cdd:cd16943 78 RIIQKHGGTIRVASVPGGGT--RFTII 102
|
|
| PRK10337 |
PRK10337 |
sensor protein QseC; Provisional |
168-463 |
9.88e-11 |
|
sensor protein QseC; Provisional
Pssm-ID: 182388 [Multi-domain] Cd Length: 449 Bit Score: 63.51 E-value: 9.88e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267689820 168 IPFLFLTLYSYVfarrfGKELnKPIKELSAASQKiknQDLDFEIKYESEN---EIGVLIDSFNSMKEELKTSLYlqwkle 244
Cdd:PRK10337 171 LPIMLIILMVLL-----GREL-APLKKLALALRM---RDPDSETPLNATGvpsEVRPLVEALNQLFARTHAMMV------ 235
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267689820 245 QERRdMVASIAHDLRTPLTIILSHVEVLM----DPSLNgQKRLPQYLQTIKNNTQRVLHLTEeMKRVSEVDNPDftlDIE 320
Cdd:PRK10337 236 RERR-FTSDAAHELRSPLAALKVQTEVAQlsddDPQAR-KKALLQLHAGIDRATRLVDQLLT-LSRLDSLDNLQ---DVA 309
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267689820 321 GVIPIEMLPEMLEEFKKWAEDEEIKFTYSLNRKPGEGNSEfaldPKRLHQILTNLISNSIRFTPVNGSIDVQVqiekDMM 400
Cdd:PRK10337 310 EIPLEDLLQSAVMDIYHTAQQAGIDVRLTLNAHPVIRTGQ----PLLLSLLVRNLLDNAIRYSPQGSVVDVTL----NAR 381
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1267689820 401 SFSICDTGKGFDTKDLPFLFSKFYQgdPSRNDQLHHGLGLYIVKELVIKHGGEIHArNNEPQG 463
Cdd:PRK10337 382 NFTVRDNGPGVTPEALARIGERFYR--PPGQEATGSGLGLSIVRRIAKLHGMNVSF-GNAPEG 441
|
|
| cpxA |
PRK09470 |
envelope stress sensor histidine kinase CpxA; |
157-470 |
1.29e-10 |
|
envelope stress sensor histidine kinase CpxA;
Pssm-ID: 236532 [Multi-domain] Cd Length: 461 Bit Score: 63.41 E-value: 1.29e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267689820 157 YIKYIF-------LIILLI--PFLFLTLYSyvfarrfgkeLNKPIKELSAASQKIKNQDldFEIKYESEN------EIGV 221
Cdd:PRK09470 160 FINLLFdrpllllLVTMLVstPLLLWLAWS----------LAKPARKLKNAADEVAQGN--LRQHPELETgpqefrQAGA 227
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267689820 222 lidSFNSMKEELKTSLYLQWKLeqerrdmVASIAHDLRTPLTIiLSHVEVLMdpslngQKRLPQY--LQTIKNNTQR--- 296
Cdd:PRK09470 228 ---SFNQMVTALERMMTSQQRL-------LSDISHELRTPLTR-LQLATALL------RRRQGESkeLERIETEAQRlds 290
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267689820 297 ------VL-------HLTEEmkrvsevdnpdftldiegVIPIEML-PEMLEEFKKWAEDEEIKFTYS--LNRKPGEGNse 360
Cdd:PRK09470 291 mindllVLsrnqqknHLERE------------------TFKANSLwSEVLEDAKFEAEQMGKSLTVSapPGPWPINGN-- 350
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267689820 361 faldPKRLHQILTNLISNSIRFTpvNGSIDVQVQIEKDMMSFSICDTGKGFDTKDLPFLFSKFYQGDPSRNDQL-HHGLG 439
Cdd:PRK09470 351 ----PNALASALENIVRNALRYS--HTKIEVAFSVDKDGLTITVDDDGPGVPEEEREQIFRPFYRVDEARDRESgGTGLG 424
|
330 340 350
....*....|....*....|....*....|.
gi 1267689820 440 LYIVKELVIKHGGEIHARNNEPQGACIEFTI 470
Cdd:PRK09470 425 LAIVENAIQQHRGWVKAEDSPLGGLRLTIWL 455
|
|
| HATPase_NtrY-like |
cd16944 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
364-470 |
2.03e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.
Pssm-ID: 340420 [Multi-domain] Cd Length: 108 Bit Score: 57.93 E-value: 2.03e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267689820 364 DPKRLHQILTNLISN---SIRFTPvNGSIDVQVQIEKDM---MSFSICDTGKGFDTKDLPFLFSKFYQGDPSRNdqlhhG 437
Cdd:cd16944 1 DTTQISQVLTNILKNaaeAIEGRP-SDVGEVRIRVEADQdgrIVLIVCDNGKGFPREMRHRATEPYVTTRPKGT-----G 74
|
90 100 110
....*....|....*....|....*....|...
gi 1267689820 438 LGLYIVKELVIKHGGEIHARNNEPQGACIEFTI 470
Cdd:cd16944 75 LGLAIVKKIMEEHGGRISLSNREAGGACIRIIL 107
|
|
| HAMP |
cd06225 |
Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; ... |
190-233 |
6.90e-10 |
|
Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The structure of the Af1503 HAMP dimer from Archaeoglobus fulgidus has been solved using nuclear magnetic resonance, revealing a parallel four-helix bundle; this structure has been confirmed by cross-linking analysis of HAMP domains from the Escherichia coli aerotaxis receptor Aer. It has been suggested that the four-helix arrangement can rotate between the unusually packed conformation observed in the NMR structure and a canonical coiled-coil arrangement. Such rotation may coincide with signal transduction, but a common mechanism by which HAMP domains relay a variety of input signals has yet to be established.
Pssm-ID: 381743 [Multi-domain] Cd Length: 45 Bit Score: 54.37 E-value: 6.90e-10
10 20 30 40
....*....|....*....|....*....|....*....|....
gi 1267689820 190 KPIKELSAASQKIKNQDLDFEIKYESENEIGVLIDSFNSMKEEL 233
Cdd:cd06225 2 RPLRRLTEAARRIAEGDLDVRVPVRSKDEIGELARAFNQMAERL 45
|
|
| PRK10755 |
PRK10755 |
two-component system sensor histidine kinase PmrB; |
166-468 |
7.22e-10 |
|
two-component system sensor histidine kinase PmrB;
Pssm-ID: 236751 [Multi-domain] Cd Length: 356 Bit Score: 60.37 E-value: 7.22e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267689820 166 LLIPFLF---LTLY-SYVFARRFGKELNKPIKELSAASQkiknQDLDFEIKYESENEIGVLIDSFNSMKEELKTSLylqw 241
Cdd:PRK10755 63 LLVPSLVmvsLTLLiCFQAVRWITRPLAELQKELEARTA----DNLTPIAIHSSTLEIEAVTSALNQLVSRLTSTL---- 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267689820 242 klEQERRdMVASIAHDLRTPLTIILSHVEvLMDPSLNGQ-----KRLPQYLQTIknntQRVLHLTeemkRVSE------V 310
Cdd:PRK10755 135 --DQERL-FTADVAHELRTPLAGIRLHLE-LLEKQHHIDvapliARLDQMMHTV----EQLLQLA----RAGQsfssghY 202
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267689820 311 DNPDFTLDIegVIPIEM-LPEMLEEFK---KWAEDEeikftySLNRKPGegnsefalDPKRLHQILTNLISNSIRFTPVN 386
Cdd:PRK10755 203 QTVKLLEDV--ILPSQDeLSEMLEQRQqtlLLPESA------ADITVQG--------DATLLRLLLRNLVENAHRYSPEG 266
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267689820 387 GSIDVQVQIEKDMMSFSICDTGKGFDTKDLPFLFSKFYqgdpsRNDQLHHG--LGLYIVKELVIKHGGEIHARNNEPQG- 463
Cdd:PRK10755 267 STITIKLSQEDGGAVLAVEDEGPGIDESKCGELSKAFV-----RMDSRYGGigLGLSIVSRITQLHHGQFFLQNRQERSg 341
|
....*..
gi 1267689820 464 --ACIEF 468
Cdd:PRK10755 342 trAWVWL 348
|
|
| KinA |
COG5805 |
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ... |
250-471 |
7.83e-10 |
|
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444507 [Multi-domain] Cd Length: 496 Bit Score: 60.90 E-value: 7.83e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267689820 250 MVASIAHDLRTPLTIILSHVEvLMDPSLNGQKrlpQYLQTIKNNTQRVLHLTEEMKRVSEVDNPDFTLdiegvipiEMLP 329
Cdd:COG5805 290 LAAGIAHEIRNPLTSIKGFLQ-LLQPGIEDKE---EYFDIMLSELDRIESIISEFLALAKPQAVNKEK--------ENIN 357
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267689820 330 EMLEEFKKWAEDEEIKFTYSLNRKPGEGNSEFALDPKRLHQILTNLISNSIRFTPVNGSIDVQVQIEKDMMSFSICDTGK 409
Cdd:COG5805 358 ELIQDVVTLLETEAILHNIQIRLELLDEDPFIYCDENQIKQVFINLIKNAIEAMPNGGTITIHTEEEDNSVIIRVIDEGI 437
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1267689820 410 GFDTKDLPFLFSKFY----QGDpsrndqlhhGLGLYIVKELVIKHGGEIHARNNEPQGA--CIEFTIS 471
Cdd:COG5805 438 GIPEERLKKLGEPFFttkeKGT---------GLGLMVSYKIIENHNGTIDIDSKVGKGTtfTITLPLS 496
|
|
| HATPase_TmoS-FixL-DctS-like |
cd16920 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
368-470 |
1.95e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340397 [Multi-domain] Cd Length: 104 Bit Score: 54.71 E-value: 1.95e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267689820 368 LHQILTNLISNSIR----FTPVNGSIDVQVQI-EKDMMSFSICDTGKGFDTKDLPFLFSKFYQgdpSRNDQLhhGLGLYI 442
Cdd:cd16920 1 IQQVLINLVRNGIEamseGGCERRELTIRTSPaDDRAVTISVKDTGPGIAEEVAGQLFDPFYT---TKSEGL--GMGLSI 75
|
90 100
....*....|....*....|....*...
gi 1267689820 443 VKELVIKHGGEIHARNNEPQGACIEFTI 470
Cdd:cd16920 76 CRSIIEAHGGRLSVESPAGGGATFQFTL 103
|
|
| HAMP |
smart00304 |
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; |
186-237 |
3.46e-09 |
|
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain;
Pssm-ID: 197640 [Multi-domain] Cd Length: 53 Bit Score: 52.64 E-value: 3.46e-09
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|..
gi 1267689820 186 KELNKPIKELSAASQKIKNQDLDFEIKYESENEIGVLIDSFNSMKEELKTSL 237
Cdd:smart00304 1 RRLLRPLRRLAEAAQRIADGDLTVRLPVDGRDEIGELARAFNEMADRLEETI 52
|
|
| HATPase_RstB-like |
cd16939 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
368-469 |
5.52e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.
Pssm-ID: 340416 [Multi-domain] Cd Length: 104 Bit Score: 53.59 E-value: 5.52e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267689820 368 LHQILTNLISNSIRFTPVNGSIDVQVQIEKdmMSFSICDTGKGFDTKDLPFLFSKFYQGDPSRNDQL-HHGLGLYIVKEL 446
Cdd:cd16939 1 MARALDNLLRNALRYAHRTVRIALLVSGGR--LTLIVEDDGPGIPAAARERVFEPFVRLDPSRDRATgGFGLGLAIVHRV 78
|
90 100
....*....|....*....|...
gi 1267689820 447 VIKHGGEIHARNNEPQGACIEFT 469
Cdd:cd16939 79 ALWHGGHVECDDSELGGACFRLT 101
|
|
| HATPase_YcbM-like |
cd16947 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
368-471 |
2.40e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).
Pssm-ID: 340423 [Multi-domain] Cd Length: 125 Bit Score: 52.52 E-value: 2.40e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267689820 368 LHQILTNLISNSIRFTPVNGSIDVQVQIEKDMMSFSICDTGKGFDTKDLPFLFSKFYQGDPSRNDQLH-HGLGLYIVKEL 446
Cdd:cd16947 21 LQRILKNLISNAIKYGSDGKFLGMTLREDEKHVYIDIWDKGKGISETEKDHVFERLYTLEDSRNSAKQgNGLGLTITKRL 100
|
90 100
....*....|....*....|....*
gi 1267689820 447 VIKHGGEIHArNNEPQGACIeFTIS 471
Cdd:cd16947 101 AESMGGSIYV-NSKPYEKTV-FTVT 123
|
|
| HAMP |
pfam00672 |
HAMP domain; |
179-235 |
2.44e-08 |
|
HAMP domain;
Pssm-ID: 459898 [Multi-domain] Cd Length: 53 Bit Score: 50.32 E-value: 2.44e-08
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*..
gi 1267689820 179 VFARRfgkeLNKPIKELSAASQKIKNQDLDFEIKYESENEIGVLIDSFNSMKEELKT 235
Cdd:pfam00672 1 LLARR----ILRPLRRLAEAARRIASGDLDVRLPVSGRDEIGELARAFNQMAERLRE 53
|
|
| HATPase_DpiB-CitA-like |
cd16915 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
371-470 |
3.38e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.
Pssm-ID: 340392 [Multi-domain] Cd Length: 104 Bit Score: 51.13 E-value: 3.38e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267689820 371 ILTNLISNSI----RFTPVNGSIDVQVQIEKDMMSFSICDTGKGFDTKDLPFLFSKFYqgdpSRNDQLHHGLGLYIVKEL 446
Cdd:cd16915 4 IVGNLIDNALdalaATGAPNKQVEVFLRDEGDDLVIEVRDTGPGIAPELRDKVFERGV----STKGQGERGIGLALVRQS 79
|
90 100
....*....|....*....|....
gi 1267689820 447 VIKHGGEIHARNNEPQGACIEFTI 470
Cdd:cd16915 80 VERLGGSITVESEPGGGTTFSIRI 103
|
|
| ComP |
COG4585 |
Signal transduction histidine kinase ComP [Signal transduction mechanisms]; |
244-470 |
5.36e-08 |
|
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
Pssm-ID: 443642 [Multi-domain] Cd Length: 252 Bit Score: 53.85 E-value: 5.36e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267689820 244 EQER----RDMVASIAHDLrtplTIILSHVEVLMDPSLNGQKRLPQYLQTIKNNTQRVLhltEEMKRVSEVDNPDfTLDI 319
Cdd:COG4585 51 EEERrriaRELHDGVGQSL----SAIKLQLEAARRLLDADPEAAREELEEIRELAREAL---AELRRLVRGLRPP-ALDD 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267689820 320 EGVIpiEMLPEMLEEFkkwAEDEEIKFTYSLNRKPGEGNSEFALDpkrLHQILTNLISNSIRFTPVNgSIDVQVQIEKDM 399
Cdd:COG4585 123 LGLA--AALEELAERL---LRAAGIRVELDVDGDPDRLPPEVELA---LYRIVQEALTNALKHAGAT-RVTVTLEVDDGE 193
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1267689820 400 MSFSICDTGKGFDTKDLPflfskfyqgdpsrndqlHHGLGLYIVKELVIKHGGEIHARNNEPQGACIEFTI 470
Cdd:COG4585 194 LTLTVRDDGVGFDPEAAP-----------------GGGLGLRGMRERAEALGGTLTIGSAPGGGTRVRATL 247
|
|
| HATPase_HupT_MifS-like |
cd16976 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
368-468 |
8.60e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.
Pssm-ID: 340435 [Multi-domain] Cd Length: 102 Bit Score: 50.15 E-value: 8.60e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267689820 368 LHQILTNLISNSIRFTP--VNGSIDVQVQIEKDMMSFSICDTGKGFDTKDLPFLFSKFYQGDPSRNDQlhhGLGLYIVKE 445
Cdd:cd16976 1 IQQVLMNLLQNALDAMGkvENPRIRIAARRLGGRLVLVVRDNGPGIAEEHLSRVFDPFFTTKPVGKGT---GLGLSISYG 77
|
90 100
....*....|....*....|...
gi 1267689820 446 LVIKHGGEIHARNNEPQGACIEF 468
Cdd:cd16976 78 IVEEHGGRLSVANEEGAGARFTF 100
|
|
| Tar |
COG0840 |
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms]; |
134-237 |
2.64e-07 |
|
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];
Pssm-ID: 440602 [Multi-domain] Cd Length: 533 Bit Score: 53.10 E-value: 2.64e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267689820 134 ILDKNRMEGVLAVRYVLASSIDYYIKYIFLIILLIPFLFLTLYSYVFARRFGKELNKPIKELSAASQKIKNQDLDFEIKY 213
Cdd:COG0840 152 LLAAAAAAAAALAALLEAAALALAAAALALALLAAALLALVALAIILALLLSRSITRPLRELLEVLERIAEGDLTVRIDV 231
|
90 100
....*....|....*....|....
gi 1267689820 214 ESENEIGVLIDSFNSMKEELKTSL 237
Cdd:COG0840 232 DSKDEIGQLADAFNRMIENLRELV 255
|
|
| RsbW |
COG2172 |
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; |
359-447 |
1.57e-06 |
|
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
Pssm-ID: 441775 [Multi-domain] Cd Length: 127 Bit Score: 47.22 E-value: 1.57e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267689820 359 SEFALDPKRLHQI---LTNLISNSIRFT---PVNGSIDVQVQIEKDMMSFSICDTGKGFDTKDLPflfskfyqgDPSRND 432
Cdd:COG2172 23 RELGLDEDDADDLvlaVSEAVTNAVRHAyggDPDGPVEVELELDPDGLEIEVRDEGPGFDPEDLP---------DPYSTL 93
|
90
....*....|....*
gi 1267689820 433 QLhHGLGLYIVKELV 447
Cdd:COG2172 94 AE-GGRGLFLIRRLM 107
|
|
| PRK13837 |
PRK13837 |
two-component system VirA-like sensor kinase; |
239-454 |
8.33e-05 |
|
two-component system VirA-like sensor kinase;
Pssm-ID: 237526 [Multi-domain] Cd Length: 828 Bit Score: 45.05 E-value: 8.33e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267689820 239 LQWKLEQERR-----DMVASIAHDLRTPLTIILSHVEVLMDpSLNGQKRLPQYLQTIKNNTQRVLHLTEEM---KRVSEV 310
Cdd:PRK13837 437 LERRLEHARRleavgTLASGIAHNFNNILGAILGYAEMALN-KLARHSRAARYIDEIISAGARARLIIDQIlafGRKGER 515
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267689820 311 DNPDFTLD--IEGVIPI--EMLPEMLE-EFKKWAEDEEIkftyslnrkpgEGNsefaldPKRLHQILTNLISNSIRFTPV 385
Cdd:PRK13837 516 NTKPFDLSelVTEIAPLlrVSLPPGVElDFDQDQEPAVV-----------EGN------PAELQQVLMNLCSNAAQAMDG 578
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267689820 386 NGSIDVQVQIEK---------------DMMSFSICDTGKGFDTKDLPFLFSKFYQGDPSRNdqlhhGLGLYIVKELVIKH 450
Cdd:PRK13837 579 AGRVDISLSRAKlrapkvlshgvlppgRYVLLRVSDTGAGIDEAVLPHIFEPFFTTRAGGT-----GLGLATVHGIVSAH 653
|
....
gi 1267689820 451 GGEI 454
Cdd:PRK13837 654 AGYI 657
|
|
| COG3920 |
COG3920 |
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ... |
371-470 |
8.71e-05 |
|
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];
Pssm-ID: 443125 [Multi-domain] Cd Length: 495 Bit Score: 44.90 E-value: 8.71e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267689820 371 ILTNLISNSIR--FTPV-NGSIDVQVQIEKDMMSFSICDTGKGFDTkdlpflfskfyQGDPSRndqlHHGLGLYIVKELV 447
Cdd:COG3920 403 ILNELVTNALKhaFLSGeGGRIRVSWRREDGRLRLTVSDNGVGLPE-----------DVDPPA----RKGLGLRLIRALV 467
|
90 100
....*....|....*....|...
gi 1267689820 448 IKHGGEIHARNnePQGACIEFTI 470
Cdd:COG3920 468 RQLGGTLELDR--PEGTRVRITF 488
|
|
| PRK10935 |
PRK10935 |
nitrate/nitrite two-component system sensor histidine kinase NarQ; |
164-238 |
1.08e-04 |
|
nitrate/nitrite two-component system sensor histidine kinase NarQ;
Pssm-ID: 236800 [Multi-domain] Cd Length: 565 Bit Score: 44.84 E-value: 1.08e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1267689820 164 IILLIPFLFLTLYSYVFARRfgkELNKPIKELSAASQKIKNQDLDF-EIKYESENEIGVLIDSFNSMKEELKTsLY 238
Cdd:PRK10935 155 LLGLILILTLVFFTVRFTRR---QVVAPLNQLVTASQQIEKGQFDHiPLDTTLPNELGLLAKAFNQMSSELHK-LY 226
|
|
| dpiB |
PRK15053 |
sensor histidine kinase DpiB; Provisional |
354-475 |
2.10e-04 |
|
sensor histidine kinase DpiB; Provisional
Pssm-ID: 185013 [Multi-domain] Cd Length: 545 Bit Score: 43.67 E-value: 2.10e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267689820 354 PGEGNSEFAldpkrlhQILTNLISN----SIRFTPVNGSIDVQVQIEKDMMSFSICDTGKGFDtkdlPFLFSK-FYQGDP 428
Cdd:PRK15053 426 PGLDSTEFA-------AIVGNLLDNafeaSLRSDEGNKIVELFLSDEGDDVVIEVADQGCGVP----ESLRDKiFEQGVS 494
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 1267689820 429 SRNDQL-HHGLGLYIVKELVIKHGGEIHARNNEPQGACIEFTISSINK 475
Cdd:PRK15053 495 TRADEPgEHGIGLYLIASYVTRCGGVITLEDNDPCGTLFSIFIPKVKP 542
|
|
| HATPase_RsbW-like |
cd16936 |
Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase ... |
375-447 |
3.30e-04 |
|
Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase involved in regulating sigma-B during stress in Bacilli, and related domains; This family includes histidine kinase-like ATPase (HATPase) domain of RsbW, an anti sigma-B factor as well as a serine-protein kinase involved in regulating sigma-B during stress in Bacilli. The alternative sigma factor sigma-B is an important regulator of the general stress response of Bacillus cereus and B. subtilis. RsbW is an anti-sigma factor while RsbV is an anti-sigma factor antagonist (anti-anti-sigma factor). RsbW can also act as a kinase on RsbV. In a partner-switching mechanism, RsbW, RsbV, and sigma-B participate as follows: in non-stressed cells, sigma-B is present in an inactive form complexed with RsbW; in this form, sigma-B is unable to bind to RNA polymerase. Under stress, RsbV binds to RsbW, forming an RsbV-RsbW complex, and sigma-B is released to bind to RNA polymerase. RsbW may then act as a kinase on RsbV, phosphorylating a serine residue; RsbW is then released to bind to sigma-B, hence blocking its ability to bind RNA polymerase. A phosphatase then dephosphorylates RsbV so that it can again form a complex with RsbW, leading to the release of sigma-B.
Pssm-ID: 340413 [Multi-domain] Cd Length: 91 Bit Score: 39.56 E-value: 3.30e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1267689820 375 LISNSIRFT---PVNGSIDVQVQIEKDMMSFSICDTGKGFDTKDLPflfskfyqgDPSRNDQLhHGLGLYIVKELV 447
Cdd:cd16936 8 AVTNAVRHAyrhDGPGPVRLELDLDPDRLRVEVTDSGPGFDPLRPA---------DPDAGLRE-GGRGLALIRALM 73
|
|
| PRK10618 |
PRK10618 |
phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional |
245-457 |
3.81e-04 |
|
phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional
Pssm-ID: 236726 [Multi-domain] Cd Length: 894 Bit Score: 43.00 E-value: 3.81e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267689820 245 QERRDMVASIAHDLRTPLTIILSHVEVLMDPSLNGQKRlpQYLQTIKNNTQRVLHLTEEMKRVSEVDNPDFTLDIEGVIP 324
Cdd:PRK10618 448 QARKAFLQNIGDELKQPLQSLAQLAAQLRQTSDEEQQQ--PELDQLAEQSDVLVRLVDNIQLLNMLETQDWKPEQELFSL 525
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267689820 325 IEMLPEMLEEFKKWAEDEEIKFTYSLNRKPgegNSEFALDPKRLHQILTNLISNSIRFTPVnGSIDVQVQIEK---DMMS 401
Cdd:PRK10618 526 QDLIDEVLPEVLPAIKRKGLQLLIHNHLKA---EQLRIGDRDALRKILLLLLNYAITTTAY-GKITLEVDQDEsspDRLT 601
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1267689820 402 FSICDTGKGFDTKDL-----PFL----FSKFYQGDpsrndqlhhGLGLYIVKELVIKHGG--EIHAR 457
Cdd:PRK10618 602 IRILDTGAGVSIKELdnlhfPFLnqtqGDRYGKAS---------GLTFFLCNQLCRKLGGhlTIKSR 659
|
|
| HATPase_PhoQ-like |
cd16954 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
361-470 |
1.31e-03 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.
Pssm-ID: 340430 [Multi-domain] Cd Length: 135 Bit Score: 38.77 E-value: 1.31e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267689820 361 FALDPKRLHQILTNLISNSIRFTpvNGSIDVQVQIEKDMMSFSICDTGKGFDTKDLPFLFSKFYQGDPSRNDqlhHGLGL 440
Cdd:cd16954 31 FPGERNDLMELLGNLLDNACKWC--LEFVEVTARQTDGGLHLIVDDDGPGVPESQRSKIFQRGQRLDEQRPG---QGLGL 105
|
90 100 110
....*....|....*....|....*....|
gi 1267689820 441 YIVKELVIKHGGEIHARNNEPQGACIEFTI 470
Cdd:cd16954 106 AIAKEIVEQYGGELSLSDSPLGGARFEVVF 135
|
|
| HATPase_c_2 |
pfam13581 |
Histidine kinase-like ATPase domain; |
363-447 |
3.66e-03 |
|
Histidine kinase-like ATPase domain;
Pssm-ID: 433327 [Multi-domain] Cd Length: 127 Bit Score: 37.65 E-value: 3.66e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267689820 363 LDPKRLHQI---LTNLISNSIRF---TPVNGSIDVQVQIEKDMMSFSICDTGKGFDTKDLPFLfskfyQGDPSRNDQLHH 436
Cdd:pfam13581 24 LPEELLDEVelaVGEACTNAVEHayrEGPEGPVEVRLTSDGGGLVVTVADSGPPFDPLTLPPP-----DLEEPDEDRKEG 98
|
90
....*....|.
gi 1267689820 437 GLGLYIVKELV 447
Cdd:pfam13581 99 GRGLALIRGLM 109
|
|
| HATPase_Phy-like |
cd16932 |
Histidine kinase-like ATPase domain of plant phytochromes similar to Arabidopsis thaliana ... |
364-455 |
5.52e-03 |
|
Histidine kinase-like ATPase domain of plant phytochromes similar to Arabidopsis thaliana Phytochrome A, B, C, D and E; This family includes the histidine kinase-like ATPase (HATPase) domains of plant red/far-red photoreceptors, the phytochromes, and includes the Arabidopsis thaliana phytochrome family phyA-phyE. Following red light absorption, biologically inactive forms of phytochromes convert to active forms, which rapidly convert back to inactive forms upon far-red light irradiation. Phytochromes can be considered as having an N-terminal photosensory region to which a bilin chromophore is bound, and a C-terminal output region, which includes the HATPase domain represented here, and is involved in dimerization and presumably contributes to relaying the light signal to downstream signaling events.
Pssm-ID: 340409 [Multi-domain] Cd Length: 113 Bit Score: 36.48 E-value: 5.52e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267689820 364 DPKRLHQILTNLISNSIRFTPV-NGSIDVQV-----QIEKDM----MSFSICDTGKGfdtkdLP-FLFSKFYQGDPsrnD 432
Cdd:cd16932 3 DQIRLQQVLADFLLNAVRFTPSpGGWVEIKVsptkkQIGDGVhvihLEFRITHPGQG-----LPeELVQEMFEENQ---W 74
|
90 100
....*....|....*....|...
gi 1267689820 433 QLHHGLGLYIVKELVIKHGGEIH 455
Cdd:cd16932 75 TTQEGLGLSISRKLVKLMNGDVR 97
|
|
| |
