|
Name |
Accession |
Description |
Interval |
E-value |
| AKR_EcYajO-like |
cd19079 |
Escherichia coli YajO and similar proteins; Escherichia coli YajO is the prototype of this ... |
2-314 |
0e+00 |
|
Escherichia coli YajO and similar proteins; Escherichia coli YajO is the prototype of this family. It is an uncharacterized aldo/keto reductase family oxidoreductase.
Pssm-ID: 381305 [Multi-domain] Cd Length: 312 Bit Score: 586.09 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 2 KYVKLGNTGLDVSRLCLGCMGFGDANKWlhQWVLNEDDSRIVIKEALDLGINFFDTANVYSLGTSEEYLGRALKDYANRD 81
Cdd:cd19079 1 EYVRLGNSGLKVSRLCLGCMSFGDPKWR--PWVLDEEESRPIIKRALDLGINFFDTANVYSGGASEEILGRALKEFAPRD 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 82 EVVIATKVHGQMHKGPNGSGLSRKAIMSEIDKSLKRLETDYVDLYIIHRWDYDTPIEETMEALHDVVKAGKARYIGASAM 161
Cdd:cd19079 79 EVVIATKVYFPMGDGPNGRGLSRKHIMAEVDASLKRLGTDYIDLYQIHRWDYETPIEETLEALHDVVKSGKVRYIGASSM 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 162 YAWQFQKALHVAEKNGWTKFVSMQNHLNLIYREGEREMLPLCKEEKIGVTPYSPLASGRLTRDWSVTTHR-SETDQIQKS 240
Cdd:cd19079 159 YAWQFAKALHLAEKNGWTKFVSMQNHYNLLYREEEREMIPLCEEEGIGVIPWSPLARGRLARPWGDTTERrRSTTDTAKL 238
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1267806617 241 KYDATADSDRLVVERVASIAEKHGIPRTHIALAWLLQKEPVTAPIIGATKTSHLENAVDALSIKLTPEEIAFLE 314
Cdd:cd19079 239 KYDYFTEADKEIVDRVEEVAKERGVSMAQVALAWLLSKPGVTAPIVGATKLEHLEDAVAALDIKLSEEEIKYLE 312
|
|
| PdxI |
COG0667 |
Pyridoxal reductase PdxI or related oxidoreductase, aldo/keto reductase family [Coenzyme ... |
1-321 |
5.09e-143 |
|
Pyridoxal reductase PdxI or related oxidoreductase, aldo/keto reductase family [Coenzyme transport and metabolism, General function prediction only];
Pssm-ID: 440431 [Multi-domain] Cd Length: 316 Bit Score: 406.10 E-value: 5.09e-143
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 1 MKYVKLGNTGLDVSRLCLGCMGFGDAnkwlhQWVLNEDDSRIVIKEALDLGINFFDTANVYSLGTSEEYLGRALKDYaNR 80
Cdd:COG0667 1 MEYRRLGRSGLKVSRLGLGTMTFGGP-----WGGVDEAEAIAILDAALDAGINFFDTADVYGPGRSEELLGEALKGR-PR 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 81 DEVVIATKVHGQMHKGPNGSGLSRKAIMSEIDKSLKRLETDYVDLYIIHRWDYDTPIEETMEALHDVVKAGKARYIGASA 160
Cdd:COG0667 75 DDVVIATKVGRRMGPGPNGRGLSREHIRRAVEASLRRLGTDYIDLYQLHRPDPDTPIEETLGALDELVREGKIRYIGVSN 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 161 MYAWQFQKALHVAEknGWTKFVSMQNHLNLIYREGEREMLPLCKEEKIGVTPYSPLASGRLTRDWSVTTHRSETDQIqKS 240
Cdd:COG0667 155 YSAEQLRRALAIAE--GLPPIVAVQNEYSLLDRSAEEELLPAARELGVGVLAYSPLAGGLLTGKYRRGATFPEGDRA-AT 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 241 KYDATADSDRL--VVERVASIAEKHGIPRTHIALAWLLQKEPVTAPIIGATKTSHLENAVDALSIKLTPEEIAFLEDPYV 318
Cdd:COG0667 232 NFVQGYLTERNlaLVDALRAIAAEHGVTPAQLALAWLLAQPGVTSVIPGARSPEQLEENLAAADLELSAEDLAALDAALA 311
|
...
gi 1267806617 319 PHP 321
Cdd:COG0667 312 AVP 314
|
|
| AKR_AKR12A1_B1_C1 |
cd19087 |
AKR12A, AKR12B, AKR12C families of aldo-keto reductase (AKR); Streptomyces fradiae TylCII, ... |
1-315 |
1.75e-125 |
|
AKR12A, AKR12B, AKR12C families of aldo-keto reductase (AKR); Streptomyces fradiae TylCII, Saccharopolyspora erythraea EryBII, and Streptomyces avermitilis aveBVIII are founding members of aldo-keto reductase family 12 member A1 (AKR12A1), B1 (AKR12B1), and C1(AKR12C1), respectively. TylCII acts as a NDP-hexose 2,3-enoyl reductase. EryBII is a mycarose/desosamine reductase involved in L-mycarose and D-desosamine production. aveBVIII functions as a dTDP-4-keto-6-deoxy-L-hexose-2,3-reductase.
Pssm-ID: 381313 [Multi-domain] Cd Length: 310 Bit Score: 361.50 E-value: 1.75e-125
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 1 MKYVKLGNTGLDVSRLCLGCMGFGDANkwlhqwvlNEDDSRIVIKEALDLGINFFDTANVYSLGTSEEYLGRALKDyaNR 80
Cdd:cd19087 1 MEYRTLGRTGLKVSRLCLGTMNFGGRT--------DEETSFAIMDRALDAGINFFDTADVYGGGRSEEIIGRWIAG--RR 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 81 DEVVIATKVHGQMHKGPNGSGLSRKAIMSEIDKSLKRLETDYVDLYIIHRWDYDTPIEETMEALHDVVKAGKARYIGASA 160
Cdd:cd19087 71 DDIVLATKVFGPMGDDPNDRGLSRRHIRRAVEASLRRLQTDYIDLYQMHHFDRDTPLEETLRALDDLVRQGKIRYIGVSN 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 161 MYAWQFQKALHVAEKNGWTKFVSMQNHLNLIYREGEREMLPLCKEEKIGVTPYSPLASGRLTRDWSVtTHRSETDQIQKS 240
Cdd:cd19087 151 FAAWQIAKAQGIAARRGLLRFVSEQPMYNLLKRQAELEILPAARAYGLGVIPYSPLAGGLLTGKYGK-GKRPESGRLVER 229
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1267806617 241 K-YDATA--DSDRLVVERVASIAEKHGIPRTHIALAWLLQKEPVTAPIIGATKTSHLENAVDALSIKLTPEEIAFLED 315
Cdd:cd19087 230 ArYQARYglEEYRDIAERFEALAAEAGLTPASLALAWVLSHPAVTSPIIGPRTLEQLEDSLAALEITLTPELLAEIDE 307
|
|
| AKR_PsAKR |
cd19091 |
Polaromonas Sp. aldo-keto reductase and similar proteins; The prototype of this family is an ... |
1-315 |
5.10e-124 |
|
Polaromonas Sp. aldo-keto reductase and similar proteins; The prototype of this family is an uncharacterized aldo-keto reductase from Polaromonas sp.
Pssm-ID: 381317 [Multi-domain] Cd Length: 319 Bit Score: 358.08 E-value: 5.10e-124
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 1 MKYVKLGNTGLDVSRLCLGCMGFGDANKWLHQW-VLNEDDSRIVIKEALDLGINFFDTANVYSLGTSEEYLGRALKDYan 79
Cdd:cd19091 1 MEYRTLGRSGLKVSELALGTMTFGGGGGFFGAWgGVDQEEADRLVDIALDAGINFFDTADVYSEGESEEILGKALKGR-- 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 80 RDEVVIATKVHGQMHKGPNGSGLSRKAIMSEIDKSLKRLETDYVDLYIIHRWDYDTPIEETMEALHDVVKAGKARYIGAS 159
Cdd:cd19091 79 RDDVLIATKVRGRMGEGPNDVGLSRHHIIRAVEASLKRLGTDYIDLYQLHGFDALTPLEETLRALDDLVRQGKVRYIGVS 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 160 AMYAWQFQKALHVAEKNGWTKFVSMQNHLNLIYREGEREMLPLCKEEKIGVTPYSPLASGRLTRDWSVTTHRSETDQIQK 239
Cdd:cd19091 159 NFSAWQIMKALGISERRGLARFVALQAYYSLLGRDLEHELMPLALDQGVGLLVWSPLAGGLLSGKYRRGQPAPEGSRLRR 238
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1267806617 240 SKYDA-TADSDRL--VVERVASIAEKHGIPRTHIALAWLLQKEPVTAPIIGATKTSHLENAVDALSIKLTPEEIAFLED 315
Cdd:cd19091 239 TGFDFpPVDRERGydVVDALREIAKETGATPAQVALAWLLSRPTVSSVIIGARNEEQLEDNLGAAGLSLTPEEIARLDK 317
|
|
| AKR_AKR9A_9B |
cd19080 |
AKR9A and AKR9B families of aldo-keto reductase (AKR); The AKR9A family includes Aspergillus ... |
6-314 |
4.54e-110 |
|
AKR9A and AKR9B families of aldo-keto reductase (AKR); The AKR9A family includes Aspergillus nidulans sterigmatocystin biosynthesis dehydrogenase StcV, Aspergillus flavus norsolorinic acid reductase (NOR), and Phanerochaete chrysosporium aryl-alcohol dehydrogenase [NADP(+)] (AAD), are founding members of aldo-keto reductase family 9 member A1-3 (AKR9A1-3), respectively. StcV may be involved in the dehydration of 5'-hydroxyaverantin to form averufin. NOR is involved in aflatoxin biosynthesis. AAD (EC1.1.1.91) is involved in lignin degradation and reduces aromatic benzaldehydes to their respective alcohols in the presence of NADP(H). The AKR9B family includes Saccharomyces cerevisiae aryl-alcohol dehydrogenases AAD14p, AAD3p, AAD4p, and AAD10p, which are founding members of aldo-keto reductase family 9 member B1-4 (AKR9B1-4), respectively.
Pssm-ID: 381306 [Multi-domain] Cd Length: 307 Bit Score: 322.25 E-value: 4.54e-110
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 6 LGNTGLDVSRLCLGCMGFGdaNKWlhQWVLNEDDSRIVIKEALDLGINFFDTANVYSLGTSEEYLGRALKDyaNRDEVVI 85
Cdd:cd19080 3 LGRSGLRVSPLALGTMTFG--TEW--GWGADREEARAMFDAYVEAGGNFIDTANNYTNGTSERLLGEFIAG--NRDRIVL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 86 ATKVHGQMHKG-PNGSGLSRKAIMSEIDKSLKRLETDYVDLYIIHRWDYDTPIEETMEALHDVVKAGKARYIGASAMYAW 164
Cdd:cd19080 77 ATKYTMNRRPGdPNAGGNHRKNLRRSVEASLRRLQTDYIDLLYVHAWDFTTPVEEVMRALDDLVRAGKVLYVGISDTPAW 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 165 QFQKALHVAEKNGWTKFVSMQNHLNLIYREGEREMLPLCKEEKIGVTPYSPLASGRLTRDWSvtthRSETDQIQKSKyDA 244
Cdd:cd19080 157 VVARANTLAELRGWSPFVALQIEYSLLERTPERELLPMARALGLGVTPWSPLGGGLLTGKYQ----RGEEGRAGEAK-GV 231
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1267806617 245 TADSDRL------VVERVASIAEKHGIPRTHIALAWLLQKEPVTAPIIGATKTSHLENAVDALSIKLTPEEIAFLE 314
Cdd:cd19080 232 TVGFGKLternwaIVDVVAAVAEELGRSAAQVALAWVRQKPGVVIPIIGARTLEQLKDNLGALDLTLSPEQLARLD 307
|
|
| AKR_AKR9C1 |
cd19081 |
AKR9C family of aldo-keto reductase (AKR); Haloferax volcanii aldo-keto reductase is a ... |
5-313 |
3.21e-109 |
|
AKR9C family of aldo-keto reductase (AKR); Haloferax volcanii aldo-keto reductase is a founding member of aldo-keto reductase family 9 member C1 (AKR9C1).
Pssm-ID: 381307 [Multi-domain] Cd Length: 308 Bit Score: 320.32 E-value: 3.21e-109
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 5 KLGNTGLDVSRLCLGCMGFGdankwlhqWVLNEDDSRIVIKEALDLGINFFDTANVYSL-------GTSEEYLGRALKDY 77
Cdd:cd19081 1 PLGRTGLSVSPLCLGTMVFG--------WTADEETSFALLDAFVDAGGNFIDTADVYSAwvpgnagGESETIIGRWLKSR 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 78 ANRDEVVIATKVHGQMhkGPNGSGLSRKAIMSEIDKSLKRLETDYVDLYIIHRWDYDTPIEETMEALHDVVKAGKARYIG 157
Cdd:cd19081 73 GKRDRVVIATKVGFPM--GPNGPGLSRKHIRRAVEASLRRLQTDYIDLYQAHWDDPATPLEETLGALNDLIRQGKVRYIG 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 158 ASAMYAWQFQKALHVAEKNGWTKFVSMQNHLNLIYREG-EREMLPLCKEEKIGVTPYSPLASGRLTrdwsvTTHRSETDq 236
Cdd:cd19081 151 ASNYSAWRLQEALELSRQHGLPRYVSLQPEYNLVDRESfEGELLPLCREEGIGVIPYSPLAGGFLT-----GKYRSEAD- 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 237 IQKSKYDATADSDRL------VVERVASIAEKHGIPRTHIALAWLLQKEPVTAPIIGATKTSHLENAVDALSIKLTPEEI 310
Cdd:cd19081 225 LPGSTRRGEAAKRYLnerglrILDALDEVAAEHGATPAQVALAWLLARPGVTAPIAGARTVEQLEDLLAAAGLRLTDEEV 304
|
...
gi 1267806617 311 AFL 313
Cdd:cd19081 305 ARL 307
|
|
| Aldo_ket_red_shaker-like |
cd19074 |
Shaker potassium channel beta subunit family and similar proteins; This family includes ... |
10-308 |
1.10e-103 |
|
Shaker potassium channel beta subunit family and similar proteins; This family includes voltage-gated potassium channel subunits, beta-1 (KCAB1B), beta-2 (KCAB2B) and beta-3 (KCAB3B). KCAB1B and KCAB2B are cytoplasmic potassium channel subunits that modulate the characteristics of the channel-forming alpha-subunits. KCAB3B is an accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. The family also includes Drosophila melanogaster Hk protein, a founding member of aldo-keto reductase family 6 member B1 (AKR6B1), as well as voltage-gated potassium channel subunit beta (KCAB) from Arabidopsis thaliana and Egeria densa, founding members of AKR6C1and AKR6C2, respectively. Hk protein, also called hyperkinetic, is a beta subunit of Shaker (Sh) K+ channels and shows high sequence homology to aldoketoreductase. KCAB, also called Shaker channel b-subunit, or K(+) channel subunit beta, or potassium voltage beta 1, or KV-beta1, or KAB1, is a probable accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit.
Pssm-ID: 381300 [Multi-domain] Cd Length: 297 Bit Score: 305.67 E-value: 1.10e-103
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 10 GLDVSRLCLGcmgfgdanKWL-HQWVLNEDDSRIVIKEALDLGINFFDTANVYSLGTSEEYLGRALKDYaNRDEVVIATK 88
Cdd:cd19074 1 GLKVSELSLG--------TWLtFGGQVDDEDAKACVRKAYDLGINFFDTADVYAAGQAEEVLGKALKGW-PRESYVISTK 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 89 VHGQMHKGPNGSGLSRKAIMSEIDKSLKRLETDYVDLYIIHRWDYDTPIEETMEALHDVVKAGKARYIGASAMYAWQFQK 168
Cdd:cd19074 72 VFWPTGPGPNDRGLSRKHIFESIHASLKRLQLDYVDIYYCHRYDPETPLEETVRAMDDLIRQGKILYWGTSEWSAEQIAE 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 169 ALHVAEKNGWTKFVSMQNHLNLIYREGEREMLPLCKEEKIGVTPYSPLASGRLT---RDWSVTTHRSeTDQIQKSKYDAT 245
Cdd:cd19074 152 AHDLARQFGLIPPVVEQPQYNMLWREIEEEVIPLCEKNGIGLVVWSPLAQGLLTgkyRDGIPPPSRS-RATDEDNRDKKR 230
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1267806617 246 ADSDRLVVERV---ASIAEKHGIPRTHIALAWLLQKEPVTAPIIGATKTSHLENAVDALSIKLTPE 308
Cdd:cd19074 231 RLLTDENLEKVkklKPIADELGLTLAQLALAWCLRNPAVSSAIIGASRPEQLEENVKASGVKLSPE 296
|
|
| AKR_AKR11B1-like |
cd19084 |
AKR11B1/AKR11B2 subfamily of aldo-keto reductase (AKR); Bacillus subtilis YhdN, also called ... |
10-314 |
1.01e-101 |
|
AKR11B1/AKR11B2 subfamily of aldo-keto reductase (AKR); Bacillus subtilis YhdN, also called general stress protein 69 (GSP69), is a founding member of aldo-keto reductase family 11 member B1 (AKR11B1). It acts as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor. Escherichia coli YdjG is a founding member of aldo-keto reductase family 11 member B2 (AKR11B2). It catalyzes the NADH-dependent reduction of methylglyoxal (2-oxopropanal) in vitro. It may play some role in intestinal colonization.
Pssm-ID: 381310 [Multi-domain] Cd Length: 296 Bit Score: 300.60 E-value: 1.01e-101
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 10 GLDVSRLCLGCMGFGDANkWLHQwvlNEDDSRIVIKEALDLGINFFDTANVYSLGTSEEYLGRALKDYanRDEVVIATKV 89
Cdd:cd19084 1 DLKVSRIGLGTWAIGGTW-WGEV---DDQESIEAIKAAIDLGINFFDTAPVYGFGHSEEILGKALKGR--RDDVVIATKC 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 90 HGQMHKGPNGS-GLSRKAIMSEIDKSLKRLETDYVDLYIIHRWDYDTPIEETMEALHDVVKAGKARYIGASAMYAWQFQK 168
Cdd:cd19084 75 GLRWDGGKGVTkDLSPESIRKEVEQSLRRLQTDYIDLYQIHWPDPNTPIEETAEALEKLKKEGKIRYIGVSNFSVEQLEE 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 169 ALHVAEkngwtkFVSMQNHLNLIYREGEREMLPLCKEEKIGVTPYSPLASGRLT------RDWSVTTHRSETDQIQKSKY 242
Cdd:cd19084 155 ARKYGP------IVSLQPPYSMLEREIEEELLPYCRENGIGVLPYGPLAQGLLTgkykkePTFPPDDRRSRFPFFRGENF 228
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1267806617 243 DATADsdrlVVERVASIAEKHGIPRTHIALAWLLQKEPVTAPIIGATKTSHLENAVDALSIKLTPEEIAFLE 314
Cdd:cd19084 229 EKNLE----IVDKLKEIAEKYGKSLAQLAIAWTLAQPGVTSAIVGAKNPEQLEENAGALDWELTEEELKEID 296
|
|
| AKR_SF |
cd06660 |
Aldo-keto reductase (AKR) superfamily; Aldo-keto reductases (AKRs) are a superfamily of ... |
14-299 |
1.51e-95 |
|
Aldo-keto reductase (AKR) superfamily; Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications. Members have very distinct functions and include the prokaryotic 2,5-diketo-D-gluconic acid reductases and beta-keto ester reductases, the eukaryotic aldose reductases, aldehyde reductases, hydroxysteroid dehydrogenases, steroid 5beta-reductases, potassium channel beta-subunits, and aflatoxin aldehyde reductases, among others.
Pssm-ID: 381296 [Multi-domain] Cd Length: 232 Bit Score: 282.49 E-value: 1.51e-95
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 14 SRLCLGCMGFGDANkwlhqwvlNEDDSRIVIKEALDLGINFFDTANVYSLGTSEEYLGRALKDYANRDEVVIATKVHGQM 93
Cdd:cd06660 1 SRLGLGTMTFGGDG--------DEEEAFALLDAALEAGGNFFDTADVYGDGRSERLLGRWLKGRGNRDDVVIATKGGHPP 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 94 HKGPNGSGLSRKAIMSEIDKSLKRLETDYVDLYIIHRWDYDTPIEETMEALHDVVKAGKARYIGASAMYAWQFQKALHVA 173
Cdd:cd06660 73 GGDPSRSRLSPEHIRRDLEESLRRLGTDYIDLYYLHRDDPSTPVEETLEALNELVREGKIRYIGVSNWSAERLAEALAYA 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 174 EKNGWTKFVSMQNHLNLIYR-EGEREMLPLCKEEKIGVTPYSPLASGrltrdwsvtthrsetdqiqkskydatadsdrlv 252
Cdd:cd06660 153 KAHGLPGFAAVQPQYSLLDRsPMEEELLDWAEENGLPLLAYSPLARG--------------------------------- 199
|
250 260 270 280
....*....|....*....|....*....|....*....|....*..
gi 1267806617 253 vervasiaekhgipRTHIALAWLLQKEPVTAPIIGATKTSHLENAVD 299
Cdd:cd06660 200 --------------PAQLALAWLLSQPFVTVPIVGARSPEQLEENLA 232
|
|
| Aldo_ket_red |
pfam00248 |
Aldo/keto reductase family; This family includes a number of K+ ion channel beta chain ... |
16-314 |
1.07e-89 |
|
Aldo/keto reductase family; This family includes a number of K+ ion channel beta chain regulatory domains - these are reported to have oxidoreductase activity.
Pssm-ID: 425554 [Multi-domain] Cd Length: 290 Bit Score: 269.95 E-value: 1.07e-89
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 16 LCLGCMGFGDANkwlhqWVLNEDDSRIVIKEALDLGINFFDTANVYSLGTSEEYLGRALKDYAN-RDEVVIATKVhgQMH 94
Cdd:pfam00248 1 IGLGTWQLGGGW-----GPISKEEALEALRAALEAGINFIDTAEVYGDGKSEELLGEALKDYPVkRDKVVIATKV--PDG 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 95 KGPNGSGLSRKAIMSEIDKSLKRLETDYVDLYIIHRWDYDTPIEETMEALHDVVKAGKARYIGASAMYAWQFQKALhvae 174
Cdd:pfam00248 74 DGPWPSGGSKENIRKSLEESLKRLGTDYIDLYYLHWPDPDTPIEETWDALEELKKEGKIRAIGVSNFDAEQIEKAL---- 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 175 KNGWTKFVSMQNHLNLIYREGEREMLPLCKEEKIGVTPYSPLASGRLTRdWSVTTHRSETDqIQKSKYDATADSDRLVVE 254
Cdd:pfam00248 150 TKGKIPIVAVQVEYNLLRRRQEEELLEYCKKNGIPLIAYSPLGGGLLTG-KYTRDPDKGPG-ERRRLLKKGTPLNLEALE 227
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 255 RVASIAEKHGIPRTHIALAWLLQKEPVTAPIIGATKTSHLENAVDALSIKLTPEEIAFLE 314
Cdd:pfam00248 228 ALEEIAKEHGVSPAQVALRWALSKPGVTIPIPGASNPEQLEDNLGALEFPLSDEEVARID 287
|
|
| AKR_AKR11B3 |
cd19085 |
Synechococcus sp. aldo-keto reductase (SakR1) and similar proteins; Synechococcus sp. SakR1 is ... |
13-315 |
1.59e-85 |
|
Synechococcus sp. aldo-keto reductase (SakR1) and similar proteins; Synechococcus sp. SakR1 is a founding member of aldo-keto reductase family 11 member B3(AKR11B3). It is responsible for methylglyoxal detoxification.
Pssm-ID: 381311 [Multi-domain] Cd Length: 292 Bit Score: 259.06 E-value: 1.59e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 13 VSRLCLGCMGFGDANKWLHQwvlNEDDSRIVIKEALDLGINFFDTANVYSLGTSEEYLGRALKDyaNRDEVVIATKVhgq 92
Cdd:cd19085 1 VSRLGLGCWQFGGGYWWGDQ---DDEESIATIHAALDAGINFFDTAEAYGDGHSEEVLGKALKG--RRDDVVIATKV--- 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 93 mhkgpNGSGLSRKAIMSEIDKSLKRLETDYVDLYIIHrW-DYDTPIEETMEALHDVVKAGKARYIGASAMYAWQFQKALH 171
Cdd:cd19085 73 -----SPDNLTPEDVRKSCERSLKRLGTDYIDLYQIH-WpSSDVPLEETMEALEKLKEEGKIRAIGVSNFGPAQLEEALD 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 172 VAekngwtKFVSMQNHLNLIYREGEREMLPLCKEEKIGVTPYSPLASGRLT------RDWSVTTHRSETDQIQKSKYDAT 245
Cdd:cd19085 147 AG------RIDSNQLPYNLLWRAIEYEILPFCREHGIGVLAYSPLAQGLLTgkfssaEDFPPGDARTRLFRHFEPGAEEE 220
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 246 ADSdrlVVERVASIAEKHGIPRTHIALAWLLQKEPVTAPIIGATKTSHLENAVDALSIKLTPEEIAFLED 315
Cdd:cd19085 221 TFE---ALEKLKEIADELGVTMAQLALAWVLQQPGVTSVIVGARNPEQLEENAAAVDLELSPSVLERLDE 287
|
|
| AKR_AKR13A_13D |
cd19076 |
AKR13A and AKR13D families of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto ... |
2-311 |
9.16e-83 |
|
AKR13A and AKR13D families of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto reductase YakC is a founding member of aldo-keto reductase family 13 member A1 (AKR13A1). It catalyzes the reversible reduction of ketones to the respective alcohols using NADP(+) as a hydride donor. Rauvolfia serpentina PR is a founding member of aldo-keto reductase family 13 member D1 (AKR13D1). It catalyzes the NADPH-dependent reduction of the aldehyde perakine to yield the alcohol raucaffrinoline in the biosynthetic pathway of ajmaline in Rauvolfia, a key step in indole alkaloid biosynthesis. This family also includes Arabidopsis thaliana aldo-keto reductases, ALKR1-6.
Pssm-ID: 381302 [Multi-domain] Cd Length: 303 Bit Score: 252.52 E-value: 9.16e-83
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 2 KYVKLGNTGLDVSRLCLGCMG----FGDANkwlhqwvlnEDDSRIVIKEALDLGINFFDTANVYSLGTSEEYLGRALKDy 77
Cdd:cd19076 1 PTRKLGTQGLEVSALGLGCMGmsafYGPAD---------EEESIATLHRALELGVTFLDTADMYGPGTNEELLGKALKD- 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 78 aNRDEVVIATK-----VHGQMHKGPNGSglsRKAIMSEIDKSLKRLETDYVDLYIIHRWDYDTPIEETMEALHDVVKAGK 152
Cdd:cd19076 71 -RRDEVVIATKfgivrDPGSGFRGVDGR---PEYVRAACEASLKRLGTDVIDLYYQHRVDPNVPIEETVGAMAELVEEGK 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 153 ARYIGASAMYAWQFQKALHVAekngwtKFVSMQNHLNLIYREGEREMLPLCKEEKIGVTPYSPLASGRLT------RDWS 226
Cdd:cd19076 147 VRYIGLSEASADTIRRAHAVH------PITAVQSEYSLWTRDIEDEVLPTCRELGIGFVAYSPLGRGFLTgaikspEDLP 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 227 VTTHRSETDQIQKSKYDATADsdrlVVERVASIAEKHGIPRTHIALAWLLQKEPVTAPIIGATKTSHLENAVDALSIKLT 306
Cdd:cd19076 221 EDDFRRNNPRFQGENFDKNLK----LVEKLEAIAAEKGCTPAQLALAWVLAQGDDIVPIPGTKRIKYLEENVGALDVVLT 296
|
....*
gi 1267806617 307 PEEIA 311
Cdd:cd19076 297 PEELA 301
|
|
| AKR_AKR11A1_11D1 |
cd19083 |
AKR11A and AKR11D families of aldo-keto reductase (AKR); Bacillus subtilis aldo-keto ... |
4-315 |
9.49e-79 |
|
AKR11A and AKR11D families of aldo-keto reductase (AKR); Bacillus subtilis aldo-keto reductase IolS, also called vegetative protein 147 (VEG147), is a founding member of aldo-keto reductase family 11 member A1 (AKR11A1). It is able to reduce the standard aldo-keto reductase (AKR) substrates DL-glyceraldehyde, D-erythrose, and methylglyoxal in the presence of NADPH, albeit with poor efficiency in vitro. Bacillus aryabhattai aldo keto reductase is a founding member of aldo-keto reductase family 11 member D1 (AKR11D1).
Pssm-ID: 381309 [Multi-domain] Cd Length: 307 Bit Score: 242.32 E-value: 9.49e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 4 VKLGNTGLDVSRLCLGCMGFGDANKWLHqwvLNEDDSRIVIKEALDLGINFFDTANVYSLGTSEEYLGRALKDYaNRDEV 83
Cdd:cd19083 2 VKLGKSDIDVNPIGLGTNAVGGHNLYPN---LDEEEGKDLVREALDNGVNLLDTAFIYGLGRSEELVGEVLKEY-NRNEV 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 84 VIATKvhGQMHKGPNGSGL--SRKAIMSEIDKSLKRLETDYVDLYIIHRWDYDTPIEETMEALHDVVKAGKARYIGASAM 161
Cdd:cd19083 78 VIATK--GAHKFGGDGSVLnnSPEFLRSAVEKSLKRLNTDYIDLYYIHFPDGETPKAEAVGALQELKDEGKIRAIGVSNF 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 162 YAWQFQKalhvAEKNGWTKFVsmQNHLNLIYREGEREMLPLCKEEKIGVTPYSPLASGRLT----RDWSVTTH--RSETD 235
Cdd:cd19083 156 SLEQLKE----ANKDGYVDVL--QGEYNLLQREAEEDILPYCVENNISFIPYFPLASGLLAgkytKDTKFPDNdlRNDKP 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 236 QIQKSKYDATADSdrlvVERVASIAEKHGIPRTHIALAWLLQKEPVTAPIIGATKTSHLENAVDALSIKLTPEEIAFLED 315
Cdd:cd19083 230 LFKGERFSENLDK----VDKLKSIADEKGVTVAHLALAWYLTRPAIDVVIPGAKRAEQVIDNLKALDVTLTEEEIAFIDA 305
|
|
| AKR_AKR14A1_2 |
cd19089 |
AKR14A family of aldo-keto reductase (AKR); Escherichia coli L-glyceraldehyde 3-phosphate ... |
3-311 |
2.42e-78 |
|
AKR14A family of aldo-keto reductase (AKR); Escherichia coli L-glyceraldehyde 3-phosphate reductase (GPR/YghZ), also called GAP reductase, is a founding member of aldo-keto reductase family 14 member A1 (AKR14A1). It catalyzes the stereospecific, NADPH-dependent reduction of L-glyceraldehyde 3-phosphate (L-GAP). It is also involved in the stress response as a methylglyoxal reductase which converts the toxic metabolite methylglyoxal to acetol in vitro and in vivo. Salmonella enterica AKR is a founding member of aldo-keto reductase family 14 member A2 (AKR14A2). It catalyzes the conversion of 3-hydroxybutanal (3-HB) to 1,3-butanediol (1,3-BDO) by using NADPH as a cofactor.
Pssm-ID: 381315 [Multi-domain] Cd Length: 308 Bit Score: 241.39 E-value: 2.42e-78
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 3 YVKLGNTGLDVSRLCLGC-MGFGDANKWLHQwvlneddsRIVIKEALDLGINFFDTANVYSL--GTSEEYLGRALKD--Y 77
Cdd:cd19089 1 YRRCGRSGLHLPAISLGLwHNFGDYTSPEEA--------RELLRTAFDLGITHFDLANNYGPppGSAEENFGRILKRdlR 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 78 ANRDEVVIATKVHGQMHKGPNGSGLSRKAIMSEIDKSLKRLETDYVDLYIIHRWDYDTPIEETMEALHDVVKAGKARYIG 157
Cdd:cd19089 73 PYRDELVISTKAGYGMWPGPYGDGGSRKYLLASLDQSLKRMGLDYVDIFYHHRYDPDTPLEETMTALADAVRSGKALYVG 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 158 ASAMYAWQFQKALHVAEKNGwTKFVSMQNHLNLIYREGEREMLPLCKEEKIGVTPYSPLASGRLTRDWSVTTHR-SETDQ 236
Cdd:cd19089 153 ISNYPGAKARRAIALLRELG-VPLIIHQPRYSLLDRWAEDGLLEVLEEAGIGFIAFSPLAQGLLTDKYLNGIPPdSRRAA 231
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1267806617 237 IQKSKYDATADSDRL-VVERVASIAEKHGIPRTHIALAWLLQKEPVTAPIIGATKTSHLENAVDAL-SIKLTPEEIA 311
Cdd:cd19089 232 ESKFLTEEALTPEKLeQLRKLNKIAAKRGQSLAQLALSWVLRDPRVTSVLIGASSPSQLEDNVAALkNLDFSEEELA 308
|
|
| AKR_AKR9A1-2 |
cd19146 |
Aspergillus nidulans sterigmatocystin biosynthesis dehydrogenase StcV, Aspergillus flavus ... |
10-317 |
1.19e-77 |
|
Aspergillus nidulans sterigmatocystin biosynthesis dehydrogenase StcV, Aspergillus flavus norsolorinic acid reductase (NOR), and similar proteins; Aspergillus nidulans sterigmatocystin biosynthesis dehydrogenase StcV and Aspergillus flavus norsolorinic acid reductase (NOR), are founding members of aldo-keto reductase family 9 member A1-2 (AKR9A1-2), respectively. StcV may be involved in the dehydration of 5'-hydroxyaverantin to form averufin. NOR is involved in aflatoxin biosynthesis.
Pssm-ID: 381372 [Multi-domain] Cd Length: 326 Bit Score: 240.40 E-value: 1.19e-77
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 10 GLDVSRLCLGCMGFGDANKWLHQwVLNEDDSRIVIKEALDLGINFFDTANVYSLGTSEEYLGRALKDYANRDEVVIATK- 88
Cdd:cd19146 8 GVRVSPLCLGAMSFGEAWKSMMG-ECDKETAFKLLDAFYEQGGNFIDTANNYQGEESERWVGEWMASRGNRDEMVLATKy 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 89 -----VHGQMHKGPNGSGLSRKAIMSEIDKSLKRLETDYVDLYIIHRWDYDTPIEETMEALHDVVKAGKARYIGASAMYA 163
Cdd:cd19146 87 ttgyrRGGPIKIKSNYQGNHAKSLRLSVEASLKKLQTSYIDILYVHWWDYTTSIPELMQSLNHLVAAGKVLYLGVSDTPA 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 164 WQFQKALHVAEKNGWTKFVSMQNHLNLIYREGEREMLPLCKEEKIGVTPYSPLASGRLTRDwsvtTHRSETDQIQKSKYD 243
Cdd:cd19146 167 WVVSKANAYARAHGLTQFVVYQGHWSAAFRDFERDILPMCEAEGMALAPWGVLGQGQFRTE----EEFKRRGRSGRKGGP 242
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1267806617 244 ATaDSDRLVVERVASIAEKHGIPRTHIALAWLLQKEPVTAPIIGATKTSHLENAVDALSIKLTPEEIAFLEDPY 317
Cdd:cd19146 243 QT-EKERKVSEKLEKVAEEKGTAITSVALAYVMHKAPYVFPIVGGRKVEHLKGNIEALGISLSDEEIQEIEDAY 315
|
|
| AKR_AKR6C1_2 |
cd19143 |
AKR6C family of aldo-keto reductase (AKR); Voltage-gated potassium channel subunit beta (KCAB) ... |
1-308 |
8.54e-77 |
|
AKR6C family of aldo-keto reductase (AKR); Voltage-gated potassium channel subunit beta (KCAB) from Arabidopsis thaliana and Egeria densa are founding members of aldo-keto reductase family 6 member C1 (AKR6C1) and C2 (AKR6C2), respectively. KCAB, also called Shaker channel b-subunit, or K(+) channel subunit beta, or potassium voltage beta 1, or KV-beta1, or KAB1, is a probable accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit.
Pssm-ID: 381369 [Multi-domain] Cd Length: 319 Bit Score: 237.88 E-value: 8.54e-77
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 1 MKYVKLGNTGLDVSRLCLGcmgfgdankwlhQWV-----LNEDDSRIVIKEALDLGINFFDTANVYSLGTSEEYLGRALK 75
Cdd:cd19143 1 MEYRRLGRSGLKVSALSFG------------SWVtfgnqVDVDEAKECMKAAYDAGVNFFDNAEVYANGQSEEIMGQAIK 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 76 DYA-NRDEVVIATKVH-GQMHKGPNGSGLSRKAIMSEIDKSLKRLETDYVDLYIIHRWDYDTPIEETMEALHDVVKAGKA 153
Cdd:cd19143 69 ELGwPRSDYVVSTKIFwGGGGPPPNDRGLSRKHIVEGTKASLKRLQLDYVDLVFCHRPDPATPIEETVRAMNDLIDQGKA 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 154 RYIGASAMYAWQFQKALHVAEKNGWTKFVSMQNHLNLIYREG-EREMLPLCKEEKIGVTPYSPLASGRLTRDWS------ 226
Cdd:cd19143 149 FYWGTSEWSAQQIEEAHEIADRLGLIPPVMEQPQYNLFHRERvEVEYAPLYEKYGLGTTTWSPLASGLLTGKYNngipeg 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 227 --VTTHRSEtdqIQKSKYDATADSDRLVVERVASIAEKHGIPRTHIALAWLLQKEPVTAPIIGATKTSHLENAVDALSI- 303
Cdd:cd19143 229 srLALPGYE---WLKDRKEELGQEKIEKVRKLKPIAEELGCSLAQLAIAWCLKNPNVSTVITGATKVEQLEENLKALEVl 305
|
....*.
gi 1267806617 304 -KLTPE 308
Cdd:cd19143 306 pKLTPE 311
|
|
| AKR_Tas-like |
cd19094 |
Escherichia coli Tas protein and similar proteins; Escherichia coli Tas protein is the ... |
13-308 |
2.22e-75 |
|
Escherichia coli Tas protein and similar proteins; Escherichia coli Tas protein is the prototype of this family. It is an NADP(H)-dependent aldo-keto reductase that catalyzes the reversible reduction of ketones to the respective alcohols using NADP(H) as a hydride donor.
Pssm-ID: 381320 [Multi-domain] Cd Length: 328 Bit Score: 234.38 E-value: 2.22e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 13 VSRLCLGCMGFGDANkwlhqwvlNEDDSRIVIKEALDLGINFFDTANVYSL-------GTSEEYLGRALKDYANRDEVVI 85
Cdd:cd19094 1 VSEICLGTMTWGEQN--------TEAEAHEQLDYAFDEGVNFIDTAEMYPVppspetqGRTEEIIGSWLKKKGNRDKVVL 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 86 ATKV----HGQMHKGPNGSGLSRKAIMSEIDKSLKRLETDYVDLYIIHRWDYDTP------------------IEETMEA 143
Cdd:cd19094 73 ATKVagpgEGITWPRGGGTRLDRENIREAVEGSLKRLGTDYIDLYQLHWPDRYTPlfgggyytepseeedsvsFEEQLEA 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 144 LHDVVKAGKARYIGASAMYAWQFQKALHVAEKNGWTKFVSMQNHLNLIYREGEREMLPLCKEEKIGVTPYSPLASGRLT- 222
Cdd:cd19094 153 LGELVKAGKIRHIGLSNETPWGVMKFLELAEQLGLPRIVSIQNPYSLLNRNFEEGLAEACHRENVGLLAYSPLAGGVLTg 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 223 --RDWSVTTHRSETDQIQKSKYDATADSDRLVVERVASIAEKHGIPRTHIALAWLLQKEPVTAPIIGATKTSHLENAVDA 300
Cdd:cd19094 233 kyLDGAARPEGGRLNLFPGYMARYRSPQALEAVAEYVKLARKHGLSPAQLALAWVRSRPFVTSTIIGATTLEQLKENIDA 312
|
....*...
gi 1267806617 301 LSIKLTPE 308
Cdd:cd19094 313 FDVPLSDE 320
|
|
| AKR_AKR11B2 |
cd19149 |
Escherichia coli NADH-specific methylglyoxal reductase (YdjG) and similar proteins; ... |
3-315 |
3.60e-75 |
|
Escherichia coli NADH-specific methylglyoxal reductase (YdjG) and similar proteins; Escherichia coli YdjG is a founding member of aldo-keto reductase family 11 member B2 (AKR11B2). It catalyzes the NADH-dependent reduction of methylglyoxal (2-oxopropanal) in vitro. It may play some role in intestinal colonization.
Pssm-ID: 381375 [Multi-domain] Cd Length: 315 Bit Score: 233.70 E-value: 3.60e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 3 YVKLGNTGLDVSRLCLGCMGFGDankWLHQWVLNEDDSRIVIKEALDLGINFFDTANVYSLGTSEEYLGRALKDYanRDE 82
Cdd:cd19149 1 YRKLGKSGIEASVIGLGTWAIGG---GPWWGGSDDNESIRTIHAALDLGINLIDTAPAYGFGHSEEIVGKAIKGR--RDK 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 83 VVIATKVhGQMHKGPNGSG------------LSRKAIMSEIDKSLKRLETDYVDLYIIHRWDYDTPIEETMEALHDVVKA 150
Cdd:cd19149 76 VVLATKC-GLRWDREGGSFffvrdgvtvyknLSPESIREEVEQSLKRLGTDYIDLYQTHWQDVETPIEETMEALEELKRQ 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 151 GKARYIGASAMYAWQFQKALHVAEKNgwtkfvSMQNHLNLIYREGEREMLPLCKEEKIGVTPYSPLASGRLT------RD 224
Cdd:cd19149 155 GKIRAIGASNVSVEQIKEYVKAGQLD------IIQEKYSMLDRGIEKELLPYCKKNNIAFQAYSPLEQGLLTgkitpdRE 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 225 WSVTTHRSETDQIQKSKYDATADsdrlVVERVASIAEKHGIPRTHIALAWLLQKEPVTAPIIGATKTSHLENAVDALSIK 304
Cdd:cd19149 229 FDAGDARSGIPWFSPENREKVLA----LLEKWKPLCEKYGCTLAQLVIAWTLAQPGITSALCGARKPEQAEENAKAGDIR 304
|
330
....*....|.
gi 1267806617 305 LTPEEIAFLED 315
Cdd:cd19149 305 LSAEDIATMRS 315
|
|
| AKR_unchar |
cd19752 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
14-302 |
6.11e-74 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381391 [Multi-domain] Cd Length: 291 Bit Score: 229.53 E-value: 6.11e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 14 SRLCLGCMGFGDANkwlhqwvlNEDDSRIVIKEALDLGINFFDTANVYSL-------GTSEEYLGRALKDYANRDEVVIA 86
Cdd:cd19752 1 SELCLGTMYFGTRT--------DEETSFAILDRYVAAGGNFLDTANNYAFwteggvgGESERLIGRWLKDRGNRDDVVIA 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 87 TKVhGQMHKGPNGS-----GLSRKAIMSEIDKSLKRLETDYVDLYIIHRWDYDTPIEETMEALHDVVKAGKARYIGASAM 161
Cdd:cd19752 73 TKV-GAGPRDPDGGpespeGLSAETIEQEIDKSLRRLGTDYIDLYYAHVDDRDTPLEETLEAFNELVKAGKVRAIGASNF 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 162 YAWQFQKALHVAEKNGWTKFVSMQNHLNLIYRE------GER----EMLPLCKEEK-IGVTPYSPLASGRLTRDWsvtth 230
Cdd:cd19752 152 AAWRLERARQIARQQGWAEFSAIQQRHSYLRPRpgadfgVQRivtdELLDYASSRPdLTLLAYSPLLSGAYTRPD----- 226
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1267806617 231 rsetdqIQKSKYDATADSDRlVVERVASIAEKHGIPRTHIALAWLLQKEPVTAPIIGATKTSHLENAVDALS 302
Cdd:cd19752 227 ------RPLPEQYDGPDSDA-RLAVLEEVAGELGATPNQVVLAWLLHRTPAIIPLLGASTVEQLEENLAALD 291
|
|
| AKR_AKR13C1_2 |
cd19078 |
AKR13C family of aldo-keto reductase (AKR); The AKR13C family includes Helicobacter pyroli ... |
10-315 |
6.56e-74 |
|
AKR13C family of aldo-keto reductase (AKR); The AKR13C family includes Helicobacter pyroli aldehyde reductase (AKR13C1) and Thermotoga maritima aldo-keto reductase (AKR13C2). Aldehyde reductase (EC 1.1.1.21), also called aldose reductase, is a cytosolic NADPH-dependent oxidoreductase that catalyzes the reduction of a variety of aldehydes and carbonyls, including monosaccharides.
Pssm-ID: 381304 [Multi-domain] Cd Length: 301 Bit Score: 229.81 E-value: 6.56e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 10 GLDVSRLCLGCMGFGDAnkwlHQWVLNEDDSRIVIKEALDLGINFFDTANVYSLGTSEEYLGRALKDYanRDEVVIATK- 88
Cdd:cd19078 1 GLEVSAIGLGCMGMSHG----YGPPPDKEEMIELIRKAVELGITFFDTAEVYGPYTNEELVGEALKPF--RDQVVIATKf 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 89 VHGQMHKGPNGSGL--SRKAIMSEIDKSLKRLETDYVDLYIIHRWDYDTPIEETMEALHDVVKAGKARYIGASAMYAWQF 166
Cdd:cd19078 75 GFKIDGGKPGPLGLdsRPEHIRKAVEGSLKRLQTDYIDLYYQHRVDPNVPIEEVAGTMKELIKEGKIRHWGLSEAGVETI 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 167 QKALHVaekngwTKFVSMQNHLNLIYREGEREMLPLCKEEKIGVTPYSPLASGRLT------RDWSVTTHRSETDQIQKS 240
Cdd:cd19078 155 RRAHAV------CPVTAVQSEYSMMWREPEKEVLPTLEELGIGFVPFSPLGKGFLTgkidenTKFDEGDDRASLPRFTPE 228
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1267806617 241 KYDATADsdrlVVERVASIAEKHGIPRTHIALAWLLQKEPVTAPIIGATKTSHLENAVDALSIKLTPEEIAFLED 315
Cdd:cd19078 229 ALEANQA----LVDLLKEFAEEKGATPAQIALAWLLAKKPWIVPIPGTTKLSRLEENIGAADIELTPEELREIED 299
|
|
| AKR_AtPLR-like |
cd19093 |
Arabidopsis thaliana pyridoxal reductase (PLR) and similar proteins; Arabidopsis thaliana PLR ... |
13-314 |
8.01e-71 |
|
Arabidopsis thaliana pyridoxal reductase (PLR) and similar proteins; Arabidopsis thaliana PLR (EC 1.1.1.65) is the prototype of this family. It catalyzes the reduction of pyridoxal (PL) with NADPH and oxidation of pyridoxine (PN) with NADP(+), and is involved in the PLP salvage pathway.
Pssm-ID: 381319 [Multi-domain] Cd Length: 293 Bit Score: 221.72 E-value: 8.01e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 13 VSRLCLGCMGFGDaNKWLHQWVLNEDDSRIVIKEALDLGINFFDTANVYSLGTSEEYLGRALKDYANRDEVVIATKVHGQ 92
Cdd:cd19093 2 VSPLGLGTWQWGD-RLWWGYGEYGDEDLQAAFDAALEAGVNLFDTAEVYGTGRSERLLGRFLKELGDRDEVVIATKFAPL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 93 MHKgpngsgLSRKAIMSEIDKSLKRLETDYVDLYIIHrW--DYDTPIEETMEALHDVVKAGKARYIGASAMYAWQFQKAL 170
Cdd:cd19093 81 PWR------LTRRSVVKALKASLERLGLDSIDLYQLH-WpgPWYSQIEALMDGLADAVEEGLVRAVGVSNYSADQLRRAH 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 171 HVAEKNGwTKFVSMQNHLNLIYREGER-EMLPLCKEEKIGVTPYSPLASGRLTRDWSVTTHRSETDQIQKSKYDATADSD 249
Cdd:cd19093 154 KALKERG-VPLASNQVEYSLLYRDPEQnGLLPACDELGITLIAYSPLAQGLLTGKYSPENPPPGGRRRLFGRKNLEKVQP 232
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1267806617 250 rlVVERVASIAEKHGIPRTHIALAWLLQKEPVtaPIIGATKTSHLENAVDALSIKLTPEEIAFLE 314
Cdd:cd19093 233 --LLDALEEIAEKYGKTPAQVALNWLIAKGVV--PIPGAKNAEQAEENAGALGWRLSEEEVAELD 293
|
|
| AKR_unchar |
cd19102 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
36-314 |
3.73e-69 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381328 [Multi-domain] Cd Length: 302 Bit Score: 217.93 E-value: 3.73e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 36 NEDDSRIVIKEALDLGINFFDTANVYSLGTSEEYLGRALKDYanRDEVVIATKVhG--QMHKGPNGSGLSRKAIMSEIDK 113
Cdd:cd19102 24 DDRDSIAAIRAALDLGINWIDTAAVYGLGHSEEVVGRALKGL--RDRPIVATKC-GllWDEEGRIRRSLKPASIRAECEA 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 114 SLKRLETDYVDLYIIHRWDYDTPIEETMEALHDVVKAGKARYIGASAMYAWQFQKAL---HVAekngwtkfvSMQNHLNL 190
Cdd:cd19102 101 SLRRLGVDVIDLYQIHWPDPDEPIEEAWGALAELKEEGKVRAIGVSNFSVDQMKRCQaihPIA---------SLQPPYSL 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 191 IYREGEREMLPLCKEEKIGVTPYSPLASGRLT----RDWSVT----THRSETDQIQKSKYDATADsdrlVVERVASIAEK 262
Cdd:cd19102 172 LRRGIEAEILPFCAEHGIGVIVYSPMQSGLLTgkmtPERVASlpadDWRRRSPFFQEPNLARNLA----LVDALRPIAER 247
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 1267806617 263 HGIPRTHIALAWLLQKEPVTAPIIGATKTSHLENAVDALSIKLTPEEIAFLE 314
Cdd:cd19102 248 HGRTVAQLAIAWVLRRPEVTSAIVGARRPDQIDETVGAADLRLTPEELAEIE 299
|
|
| YdhF |
COG4989 |
Predicted oxidoreductase YdhF [General function prediction only]; |
1-309 |
4.16e-67 |
|
Predicted oxidoreductase YdhF [General function prediction only];
Pssm-ID: 444013 [Multi-domain] Cd Length: 299 Bit Score: 212.32 E-value: 4.16e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 1 MKYVKLGNTGLDVSRLCLGCMGFGDANkwlhqwvLNEDDSRIVIKEALDLGINFFDTANVYSLGTSEEYLGRALK-DYAN 79
Cdd:COG4989 1 MKRIKLGASGLSVSRIVLGCMRLGEWD-------LSPAEAAALIEAALELGITTFDHADIYGGYTCEALFGEALKlSPSL 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 80 RDEVVIATK-----VHGQMHKGPNGSGLSRKAIMSEIDKSLKRLETDYVDLYIIHRWDYDTPIEETMEALHDVVKAGKAR 154
Cdd:COG4989 74 REKIELQTKcgirlPSEARDNRVKHYDTSKEHIIASVEGSLRRLGTDYLDLLLLHRPDPLMDPEEVAEAFDELKASGKVR 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 155 YIGASAMYAWQF---QKALHvaekngwTKFVSMQNHLNLIYREG-EREMLPLCKEEKIGVTPYSPLASGRLTRDwsvtth 230
Cdd:COG4989 154 HFGVSNFTPSQFellQSALD-------QPLVTNQIELSLLHTDAfDDGTLDYCQLNGITPMAWSPLAGGRLFGG------ 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 231 rsETDQIQKskydatadsdrlVVERVASIAEKHGIPRTHIALAWLLqKEPVTA-PIIGATKTSHLENAVDALSIKLTPEE 309
Cdd:COG4989 221 --FDEQFPR------------LRAALDELAEKYGVSPEAIALAWLL-RHPAGIqPVIGTTNPERIKAAAAALDIELTREE 285
|
|
| AKR_AKR10A1_2 |
cd19082 |
AKR10A family of aldo-keto reductase (AKR); Streptomyces bluensis aldo-keto reductase (BlmT) ... |
14-302 |
1.35e-66 |
|
AKR10A family of aldo-keto reductase (AKR); Streptomyces bluensis aldo-keto reductase (BlmT) and Streptomyces glaucescens aldo-keto reductase (StrT) are founding members of aldo-keto reductase family 10 member A1 (AKR10A1) and A2 (AKR10A2). BlmT is bluensomycin aldo-keto reductase (AKR) and StrT is streptomycin AKR.
Pssm-ID: 381308 [Multi-domain] Cd Length: 291 Bit Score: 210.87 E-value: 1.35e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 14 SRLCLGCMGFGDAnkwlhqwvLNEDDSRIVIKEALDLGINFFDTANVYS----LGTSEEYLGRALKDYANRDEVVIATKv 89
Cdd:cd19082 1 SRIVLGTADFGTR--------IDEEEAFALLDAFVELGGNFIDTARVYGdwveRGASERVIGEWLKSRGNRDKVVIATK- 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 90 hGQMHKGPNGSG--LSRKAIMSEIDKSLKRLETDYVDLYIIHRWDYDTPIEETMEALHDVVKAGKARYIGASAMYAWQFQ 167
Cdd:cd19082 72 -GGHPDLEDMSRsrLSPEDIRADLEESLERLGTDYIDLYFLHRDDPSVPVGEIVDTLNELVRAGKIRAFGASNWSTERIA 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 168 KALHVAEKNGWTKFVSMQNHLNLIYREGER-----------EMLPLCKEEKIGVTPYSPLASGRLTRdwsVTTHRSETDQ 236
Cdd:cd19082 151 EANAYAKAHGLPGFAASSPQWSLARPNEPPwpgptlvamdeEMRAWHEENQLPVFAYSSQARGFFSK---RAAGGAEDDS 227
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1267806617 237 IQKSKYDATADSDRLvvERVASIAEKHGIPRTHIALAWLLQKEPVTAPIIGATKTSHLENAVDALS 302
Cdd:cd19082 228 ELRRVYYSEENFERL--ERAKELAEEKGVSPTQIALAYVLNQPFPTVPIIGPRTPEQLRDSLAAAD 291
|
|
| AKR_AKR3F1-like |
cd19072 |
Thermotoga maritime Tm1743, Escherichia coli YeaE and similar proteins; Thermotoga maritime ... |
10-314 |
3.54e-64 |
|
Thermotoga maritime Tm1743, Escherichia coli YeaE and similar proteins; Thermotoga maritime Tm1743 is a founding member of aldo-keto reductase family 3 member F1 (AKR3F1). It is a aldo/keto reductase family oxidoreductase. Escherichia coli YeaE may act as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.
Pssm-ID: 381298 [Multi-domain] Cd Length: 263 Bit Score: 203.61 E-value: 3.54e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 10 GLDVSRLCLGCMGFGdaNKWLHQwvlNEDDSRIV--IKEALDLGINFFDTANVYSLGTSEEYLGRALKDYaNRDEVVIAT 87
Cdd:cd19072 1 GEEVPVLGLGTWGIG--GGMSKD---YSDDKKAIeaLRYAIELGINLIDTAEMYGGGHAEELVGKAIKGF-DREDLFITT 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 88 KVhgqmhkgpNGSGLSRKAIMSEIDKSLKRLETDYVDLYIIHRWDYDTPIEETMEALHDVVKAGKARYIGASAMYAWQFQ 167
Cdd:cd19072 75 KV--------SPDHLKYDDVIKAAKESLKRLGTDYIDLYLIHWPNPSIPIEETLRAMEELVEEGKIRYIGVSNFSLEELE 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 168 KALHVAEKNgwtKFVSMQNHLNLIYREGEREMLPLCKEEKIGVTPYSPLASGRLTRDwsvttHRSETdqiqkskydatad 247
Cdd:cd19072 147 EAQSYLKKG---PIVANQVEYNLFDREEESGLLPYCQKNGIAIIAYSPLEKGKLSNA-----KGSPL------------- 205
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1267806617 248 sdrlvverVASIAEKHGIPRTHIALAWLLQKePVTAPIIGATKTSHLENAVDALSIKLTPEEIAFLE 314
Cdd:cd19072 206 --------LDEIAKKYGKTPAQIALNWLISK-PNVIAIPKASNIEHLEENAGALGWELSEEDLQRLD 263
|
|
| AKR_AKR11C1 |
cd19086 |
AKR11C family of aldo-keto reductase (AKR); Bacillus subtilis uncharacterized oxidoreductase ... |
11-300 |
1.47e-63 |
|
AKR11C family of aldo-keto reductase (AKR); Bacillus subtilis uncharacterized oxidoreductase YqkF is a founding member of aldo-keto reductase family 11 member C1 (AKR11C1). It may function as oxidoreductase. This family also includes Bacillus halodurans AKR11C1, an NADPH-dependent 4-hydroxy-2,3-trans-nonenal reductase.
Pssm-ID: 381312 [Multi-domain] Cd Length: 238 Bit Score: 201.17 E-value: 1.47e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 11 LDVSRLCLGCMGFGdaNKWLHqwVLNEDDSRIVIKEALDLGINFFDTANVYSLGTSEEYLGRALKDyaNRDEVVIATKV- 89
Cdd:cd19086 1 LEVSEIGFGTWGLG--GDWWG--DVDDAEAIRALRAALDLGINFFDTADVYGDGHSERLLGKALKG--RRDKVVIATKFg 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 90 HGQMHKGPNGSGLSRKAIMSEIDKSLKRLETDYVDLYIIHRWDYD-TPIEETMEALHDVVKAGKARYIGASAMYAWQFQK 168
Cdd:cd19086 75 NRFDGGPERPQDFSPEYIREAVEASLKRLGTDYIDLYQLHNPPDEvLDNDELFEALEKLKQEGKIRAYGVSVGDPEEALA 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 169 ALhvaeKNGWTKFVSMQnhLNLIYREGEREMLPLCKEEKIGVTPYSPLASGRLTrdwsvtthrsetdqiqkskydatads 248
Cdd:cd19086 155 AL----RRGGIDVVQVI--YNLLDQRPEEELFPLAEEHGVGVIARVPLASGLLT-------------------------- 202
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 1267806617 249 DRLVvervasiaekhgiprtHIALAWLLQKEPVTAPIIGATKTSHLENAVDA 300
Cdd:cd19086 203 GKLA----------------QAALRFILSHPAVSTVIPGARSPEQVEENAAA 238
|
|
| AKR_AKR9A3_9B1-4 |
cd19147 |
Phanerochaete chrysosporium aryl-alcohol dehydrogenase [NADP(+)] (AAD) and similar proteins; ... |
10-314 |
1.80e-62 |
|
Phanerochaete chrysosporium aryl-alcohol dehydrogenase [NADP(+)] (AAD) and similar proteins; Phanerochaete chrysosporium ADD (EC1.1.1.91) is a founding member of aldo-keto reductase family 9 member A3. It is involved in lignin degradation and reduces aromatic benzaldehydes to their respective alcohols in the presence of NADP(H). This family also includes Saccharomyces cerevisiae aryl-alcohol dehydrogenases AAD14p, AAD3p, AAD4p, and AAD10p, which are founding members of aldo-keto reductase family 9 member B1-4 (AKR9B1-4), respectively.
Pssm-ID: 381373 [Multi-domain] Cd Length: 319 Bit Score: 201.21 E-value: 1.80e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 10 GLDVSRLCLGCMGFGDAnkwlhqW-----VLNEDDSRIVIKEALDLGINFFDTANVYSLGTSEEYLGRALKDYANRDEVV 84
Cdd:cd19147 7 GIRVSPLILGAMSIGDA------WsgfmgSMDKEQAFELLDAFYEAGGNFIDTANNYQDEQSETWIGEWMKSRKNRDQIV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 85 IATKVHGQMHKGPNGSGLS-------RKAIMSEIDKSLKRLETDYVDLYIIHRWDYDTPIEETMEALHDVVKAGKARYIG 157
Cdd:cd19147 81 IATKFTTDYKAYEVGKGKAvnycgnhKRSLHVSVRDSLRKLQTDWIDILYVHWWDYTTSIEEVMDSLHILVQQGKVLYLG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 158 ASAMYAWQFQKALHVAEKNGWTKFVSMQNHLNLIYREGEREMLPLCKEEKIGVTPYSPLASGRLTRDWSVtTHRSETDQI 237
Cdd:cd19147 161 VSDTPAWVVSAANYYATAHGKTPFSVYQGRWNVLNRDFERDIIPMARHFGMALAPWDVLGGGKFQSKKAV-EERKKNGEG 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 238 QKSKYDATADSDRLVV--ERVASIAEKHGIPR-THIALAWLLQKEPVTAPIIGATKTSHLENAVDALSIKLTPEEIAFLE 314
Cdd:cd19147 240 LRSFVGGTEQTPEEVKisEALEKVAEEHGTESvTAIALAYVRSKAPNVFPLVGGRKIEHLKDNIEALSIKLTPEEIEYLE 319
|
|
| AKR_AKR14A2 |
cd19151 |
Salmonella enterica aldo-keto reductase (AKR) and similar protein; Salmonella enterica AKR is ... |
2-311 |
2.06e-62 |
|
Salmonella enterica aldo-keto reductase (AKR) and similar protein; Salmonella enterica AKR is a founding member of aldo-keto reductase family 14 member A2 (AKR14A2).
Pssm-ID: 381377 [Multi-domain] Cd Length: 309 Bit Score: 200.71 E-value: 2.06e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 2 KYVKLGNTGLDVSRLCLGCM-GFGDANKWlhqwvlneDDSRIVIKEALDLGINFFDTANVYS--LGTSEEYLGRALKD-- 76
Cdd:cd19151 1 KYNRCGRSGLKLPAISLGLWhNFGDVDRY--------ENSRAMLRRAFDLGITHFDLANNYGppPGSAEENFGRILKEdl 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 77 YANRDEVVIATKVHGQMHKGPNGSGLSRKAIMSEIDKSLKRLETDYVDLYIIHRWDYDTPIEETMEALHDVVKAGKARYI 156
Cdd:cd19151 73 KPYRDELIISTKAGYTMWPGPYGDWGSKKYLIASLDQSLKRMGLDYVDIFYHHRPDPETPLEETMGALDQIVRQGKALYV 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 157 GASAMYAWQFQKALHVAEKNGwTKFVSMQNHLNLIYREGEREMLPLCKEEKIGVTPYSPLASGRLT--------RDWSVT 228
Cdd:cd19151 153 GISNYPPEEAREAAAILKDLG-TPCLIHQPKYSMFNRWVEEGLLDVLEEEGIGCIAFSPLAQGLLTdrylngipEDSRAA 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 229 THRS--ETDQIQKSKYDAtadsdrlvVERVASIAEKHGIPRTHIALAWLLQKEPVTAPIIGATKTSHLENAVDALS-IKL 305
Cdd:cd19151 232 KGSSflKPEQITEEKLAK--------VRRLNEIAQARGQKLAQMALAWVLRNKRVTSVLIGASKPSQIEDAVGALDnREF 303
|
....*.
gi 1267806617 306 TPEEIA 311
Cdd:cd19151 304 SEEELA 309
|
|
| AKR_AKR13D1 |
cd19145 |
AKR13D family of aldo-keto reductase (AKR); Rauvolfia serpentina PR is a founding member of ... |
4-311 |
2.48e-61 |
|
AKR13D family of aldo-keto reductase (AKR); Rauvolfia serpentina PR is a founding member of aldo-keto reductase family 13 member D1 (AKR13D1). It catalyzes the NADPH-dependent reduction of the aldehyde perakine to yield the alcohol raucaffrinoline in the biosynthetic pathway of ajmaline in Rauvolfia, a key step in indole alkaloid biosynthesis. This family also includes Arabidopsis thaliana aldo-keto reductases, ALKR1-6.
Pssm-ID: 381371 [Multi-domain] Cd Length: 304 Bit Score: 197.65 E-value: 2.48e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 4 VKLGNTGLDVSRLCLGCMGfgdankwLHQWV---LNEDDSRIVIKEALDLGINFFDTANVYSLGTSEEYLGRALKDyANR 80
Cdd:cd19145 3 VKLGSQGLEVSAQGLGCMG-------LSGDYgapKPEEEGIALIHHAFNSGVTFLDTSDIYGPNTNEVLLGKALKD-GPR 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 81 DEVVIATKVHgqmHKGPNGSGLSRKA----IMSEIDKSLKRLETDYVDLYIIHRWDYDTPIEETMEALHDVVKAGKARYI 156
Cdd:cd19145 75 EKVQLATKFG---IHEIGGSGVEVRGdpayVRAACEASLKRLDVDYIDLYYQHRIDTTVPIEITMGELKKLVEEGKIKYI 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 157 GASAMYAWQFQKALHVAekngwtKFVSMQNHLNLIYREGEREMLPLCKEEKIGVTPYSPLASG------RLTRDWSVTTH 230
Cdd:cd19145 152 GLSEASADTIRRAHAVH------PITAVQLEWSLWTRDIEEEIIPTCRELGIGIVPYSPLGRGffagkaKLEELLENSDV 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 231 RSETDQIQKSkydaTADSDRLVVERVASIAEKHGIPRTHIALAWLLQKEPVTAPIIGATKTSHLENAVDALSIKLTPEEI 310
Cdd:cd19145 226 RKSHPRFQGE----NLEKNKVLYERVEALAKKKGCTPAQLALAWVLHQGEDVVPIPGTTKIKNLNQNIGALSVKLTKEDL 301
|
.
gi 1267806617 311 A 311
Cdd:cd19145 302 K 302
|
|
| AKR_BsYcsN_EcYdhF-like |
cd19092 |
Bacillus subtilis YcsN, Escherichia coli YdhF and similar proteins; Bacillus subtilis YcsN and ... |
8-309 |
3.32e-59 |
|
Bacillus subtilis YcsN, Escherichia coli YdhF and similar proteins; Bacillus subtilis YcsN and Escherichia coli YdhF are prototypes of this family. They are uncharacterized aldo/keto reductase family oxidoreductases.
Pssm-ID: 381318 [Multi-domain] Cd Length: 287 Bit Score: 191.62 E-value: 3.32e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 8 NTGLDVSRLCLGCMGFGDankwlhqwvLNEDDSRI--VIKEALDLGINFFDTANVYSLGTSEEYLGRALKDYAN-RDEVV 84
Cdd:cd19092 1 PEGLEVSRLVLGCMRLAD---------WGESAEELlsLIEAALELGITTFDHADIYGGGKCEELFGEALALNPGlREKIE 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 85 IATKVhGQMHKGPNGSG------LSRKAIMSEIDKSLKRLETDYVDLYIIHRWDYDTPIEETMEALHDVVKAGKARYIGA 158
Cdd:cd19092 72 IQTKC-GIRLGDDPRPGrikhydTSKEHILASVEGSLKRLGTDYLDLLLLHRPDPLMDPEEVAEAFDELVKSGKVRYFGV 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 159 SAMYAWQF---QKALHVaekngwtKFVSMQNHLNLIYREG-EREMLPLCKEEKIGVTPYSPLASGRLTRDwsvtthrsET 234
Cdd:cd19092 151 SNFTPSQIellQSYLDQ-------PLVTNQIELSLLHTEAiDDGTLDYCQLLDITPMAWSPLGGGRLFGG--------FD 215
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1267806617 235 DQIQKskydatadsdrlVVERVASIAEKHGIPRTHIALAWLLqKEPVTA-PIIGATKTSHLENAVDALSIKLTPEE 309
Cdd:cd19092 216 ERFQR------------LRAALEELAEEYGVTIEAIALAWLL-RHPARIqPILGTTNPERIRSAVKALDIELTREE 278
|
|
| AKR_AKR13B1 |
cd19088 |
AKR13B family of aldo-keto reductase (AKR); Xylella fastidiosa phenylacetaldehyde ... |
13-306 |
8.70e-59 |
|
AKR13B family of aldo-keto reductase (AKR); Xylella fastidiosa phenylacetaldehyde dehydrogenase is a founding member of aldo-keto reductase family 13 member B1 (AKR13B1). phenylacetaldehyde dehydrogenase (EC 1.2.1.39) catalyzes the NAD+-dependent oxidation of phenylactealdehyde to phenylacetic acid.
Pssm-ID: 381314 [Multi-domain] Cd Length: 256 Bit Score: 189.74 E-value: 8.70e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 13 VSRLCLGCMGFGdankWLHQWVL--NEDDSRIVIKEALDLGINFFDTANVYSLGTSEEYLGRALKDYanRDEVVIATKV- 89
Cdd:cd19088 1 VSRLGYGAMRLT----GPGIWGPpaDREEAIAVLRRALELGVNFIDTADSYGPDVNERLIAEALHPY--PDDVVIATKGg 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 90 ---HGQMHKGPNGSglsRKAIMSEIDKSLKRLETDYVDLYIIHRWDYDTPIEETMEALHDVVKAGKARYIGASAMYAWQF 166
Cdd:cd19088 75 lvrTGPGWWGPDGS---PEYLRQAVEASLRRLGLDRIDLYQLHRIDPKVPFEEQLGALAELQDEGLIRHIGLSNVTVAQI 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 167 QKALHVAEkngwtkFVSMQNHLNLIYREGErEMLPLCKEEKIGVTPYSPLASGRLTRDwsvtthrsetdqiqkskydata 246
Cdd:cd19088 152 EEARAIVR------IVSVQNRYNLANRDDE-GVLDYCEAAGIAFIPWFPLGGGDLAQP---------------------- 202
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 247 dsdrlvVERVASIAEKHGIPRTHIALAWLLQKEPVTAPIIGATKTSHLENAVDALSIKLT 306
Cdd:cd19088 203 ------GGLLAEVAARLGATPAQVALAWLLARSPVMLPIPGTSSVEHLEENLAAAGLRLS 256
|
|
| AKR_AKR11B1 |
cd19148 |
Bacillus subtilis aldo-keto reductase YhdN and similar proteins; Bacillus subtilis YhdN, also ... |
10-309 |
6.94e-57 |
|
Bacillus subtilis aldo-keto reductase YhdN and similar proteins; Bacillus subtilis YhdN, also called general stress protein 69 (GSP69), is a founding member of aldo-keto reductase family 11 member B1 (AKR11B1). It acts as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.
Pssm-ID: 381374 [Multi-domain] Cd Length: 302 Bit Score: 186.36 E-value: 6.94e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 10 GLDVSRLCLGCMGFGDankWLhqW-VLNEDDSRIVIKEALDLGINFFDTANVYSLGTSEEYLGRALKDYANRDEVVIATK 88
Cdd:cd19148 1 DLPVSRIALGTWAIGG---WM--WgGTDEKEAIETIHKALDLGINLIDTAPVYGFGLSEEIVGKALKEYGKRDRVVIATK 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 89 VHGQMHKGPNGSGLSRKA-IMSEIDKSLKRLETDYVDLYIIHRWDYDTPIEETMEALHDVVKAGKARYIGASAMYAWQ-- 165
Cdd:cd19148 76 VGLEWDEGGEVVRNSSPArIRKEVEDSLRRLQTDYIDLYQVHWPDPLVPIEETAEALKELLDEGKIRAIGVSNFSPEQme 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 166 -FQKA--LHVaekngwtkfvsMQNHLNLIYREGEREMLPLCKEEKIGVTPYSPLA----SGRLTRDWSVTTH--RSETDQ 236
Cdd:cd19148 156 tFRKVapLHT-----------VQPPYNLFEREIEKDVLPYARKHNIVTLAYGALCrgllSGKMTKDTKFEGDdlRRTDPK 224
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1267806617 237 IQKSKYDATADSdrlvVERVASIA-EKHGIPRTHIALAWLLQKEPVTAPIIGATKTSHLENAVDALSIKLTPEE 309
Cdd:cd19148 225 FQEPRFSQYLAA----VEELDKLAqERYGKSVIHLAVRWLLDQPGVSIALWGARKPEQLDAVDEVFGWSLNDED 294
|
|
| AKR_unchar |
cd19105 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
1-301 |
4.94e-55 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381331 [Multi-domain] Cd Length: 250 Bit Score: 179.70 E-value: 4.94e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 1 MKYVKLGNTGLDVSRLCLGCMGFGDANKwlhqwvlneddsrIVIKEALDLGINFFDTANVYSLGTSEEYLGRALKDYaNR 80
Cdd:cd19105 1 MPYRTLGKTGLKVSRLGFGGGGLPRESP-------------ELLRRALDLGINYFDTAEGYGNGNSEEIIGEALKGL-RR 66
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 81 DEVVIATKVHGQMHKGpngsglSRKAIMSEIDKSLKRLETDYVDLYIIHRWDYDTPI---EETMEALHDVVKAGKARYIG 157
Cdd:cd19105 67 DKVFLATKASPRLDKK------DKAELLKSVEESLKRLQTDYIDIYQLHGVDTPEERllnEELLEALEKLKKEGKVRFIG 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 158 ASAMYAwQFQKALHVAEKNGWTKFVSMQNHLNliYREGEREMLPLCKEEKIGVTPYSPLASGRLtRDWSVTTHRSEtdqi 237
Cdd:cd19105 141 FSTHDN-MAEVLQAAIESGWFDVIMVAYNFLN--QPAELEEALAAAAEKGIGVVAMKTLAGGYL-QPALLSVLKAK---- 212
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1267806617 238 qkskydatadsdrlvvervasiaekhGIPRTHIALAWLLQKEPVTAPIIGATKTSHLENAVDAL 301
Cdd:cd19105 213 --------------------------GFSLPQAALKWVLSNPRVDTVVPGMRNFAELEENLAAA 250
|
|
| AKR_AKR7A1-5 |
cd19075 |
AKR7A family of aldo-keto reductase (AKR); Aflatoxin B1 aldehyde reductase member 1/3 (AKR7A1 ... |
15-302 |
1.51e-54 |
|
AKR7A family of aldo-keto reductase (AKR); Aflatoxin B1 aldehyde reductase member 1/3 (AKR7A1/AKR7A3/AFAR) from Rattus norvegicus, aflatoxin B1 aldehyde reductase member 2 (AKR7A2/AFAR1/AFAR) and aflatoxin B1 aldehyde reductase member 3 (AKR7A3/AFAR2) from Homo sapiens, aflatoxin B1 aldehyde reductase member 2 (AKR7A2/AFAR2) from Rattus norvegicus, and aflatoxin B1 aldehyde reductase member 2 (AKR7A2/AKR7A5/AFAR) from Mus musculus, are founding members of aldo-keto reductase family 7 member A1-5 (AKR7A1-5), respectively. AKR7A2 (EC 1.1.1.n11), also called AFB1 aldehyde reductase 1, or AFB1-AR 1, or aldoketoreductase 7, or succinic semialdehyde reductase, or SSA reductase, catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate (GHB). It has NADPH-dependent aldehyde reductase activity towards 2-carboxybenzaldehyde, 2-nitrobenzaldehyde and pyridine-2-aldehyde (in vitro). AKR7A2, AKR7A3 (also called AFB1 aldehyde reductase 2 or AFB1-AR 2), and AKR7A4 (also called AFB1 aldehyde reductase 3, or AFB1-AR 3, or aldoketoreductase 7-like), may be involved in protection of liver against the toxic and carcinogenic effects of aflatoxin B1 (AFB1), a potent hepatocarcinogen. They can reduce the dialdehyde protein-binding form of AFB1 to the non-binding AFB1 dialcohol.
Pssm-ID: 381301 [Multi-domain] Cd Length: 304 Bit Score: 180.06 E-value: 1.51e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 15 RLCLGCMGFGDANKwlhqwVLNEDDSRIVIKEALDLGINFFDTANVYSLGTSEEYLGRAlkDYANRDeVVIATKVHGqmh 94
Cdd:cd19075 2 KIILGTMTFGSQGR-----FTTAEAAAELLDAFLERGHTEIDTARVYPDGTSEELLGEL--GLGERG-FKIDTKANP--- 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 95 kGPNGsGLSRKAIMSEIDKSLKRLETDYVDLYIIHRWDYDTPIEETMEALHDVVKAGKARYIGASAMYAWQFQKALHVAE 174
Cdd:cd19075 71 -GVGG-GLSPENVRKQLETSLKRLKVDKVDVFYLHAPDRSTPLEETLAAIDELYKEGKFKEFGLSNYSAWEVAEIVEICK 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 175 KNGWTKFVSMQNHLNLIYREGEREMLPLCKEEKIGVTPYSPLASGRLTRdwsvtTHRSETDQIQKSKYDATA-------- 246
Cdd:cd19075 149 ENGWVLPTVYQGMYNAITRQVETELFPCLRKLGIRFYAYSPLAGGFLTG-----KYKYSEDKAGGGRFDPNNalgklyrd 223
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1267806617 247 --DSDRLV--VERVASIAEKHGIPRTHIALAWL-----LQKEPVTAPIIGATKTSHLENAVDALS 302
Cdd:cd19075 224 ryWKPSYFeaLEKVEEAAEKEGISLAEAALRWLyhhsaLDGEKGDGVILGASSLEQLEENLAALE 288
|
|
| COG1453 |
COG1453 |
Predicted oxidoreductase of the aldo/keto reductase family [General function prediction only]; |
1-315 |
2.36e-54 |
|
Predicted oxidoreductase of the aldo/keto reductase family [General function prediction only];
Pssm-ID: 441062 [Multi-domain] Cd Length: 365 Bit Score: 181.56 E-value: 2.36e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 1 MKYVKLGNTGLDVSRLCLGCMGFGdankwlhqwVLNEDDSRIVIKEALDLGINFFDTANVYslGTSEEYLGRALKDYanR 80
Cdd:COG1453 1 MQYRRLGKTGLEVSVLGFGGMRLP---------RKDEEEAEALIRRAIDNGINYIDTARGY--GDSEEFLGKALKGP--R 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 81 DEVVIATKVHGQMHkgpngsglSRKAIMSEIDKSLKRLETDYVDLYIIH----RWDYDTPIEET--MEALHDVVKAGKAR 154
Cdd:COG1453 68 DKVILATKLPPWVR--------DPEDMRKDLEESLKRLQTDYIDLYLIHglntEEDLEKVLKPGgaLEALEKAKAEGKIR 139
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 155 YIGASA-MYAWQFQKALhvaEKNGWTkFVsmQNHLNLIYRE--GEREMLPLCKEEKIGVTPYSPLASGRLTRdwsvtthr 231
Cdd:COG1453 140 HIGFSThGSLEVIKEAI---DTGDFD-FV--QLQYNYLDQDnqAGEEALEAAAEKGIGVIIMKPLKGGRLAN-------- 205
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 232 sETDQIQKskydatadsdrlVVERVASIAEkhgiprthIALAWLLQKEPVTAPIIGATKTSHLENAVDALS--IKLTPEE 309
Cdd:COG1453 206 -PPEKLVE------------LLCPPLSPAE--------WALRFLLSHPEVTTVLSGMSTPEQLDENLKTADnlEPLTEEE 264
|
....*.
gi 1267806617 310 IAFLED 315
Cdd:COG1453 265 LAILER 270
|
|
| tas |
PRK10625 |
putative aldo-keto reductase; Provisional |
1-315 |
3.10e-53 |
|
putative aldo-keto reductase; Provisional
Pssm-ID: 236727 [Multi-domain] Cd Length: 346 Bit Score: 178.12 E-value: 3.10e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 1 MKYVKLGNTGLDVSRLCLGCMGFGDANkwlhqwvlNEDDSRIVIKEALDLGINFFDTANVYSL-------GTSEEYLGRA 73
Cdd:PRK10625 1 MQYHRIPHSSLEVSTLGLGTMTFGEQN--------SEADAHAQLDYAVAQGINLIDVAEMYPVpprpetqGLTETYIGNW 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 74 LKDYANRDEVVIATKVHGQMHKGPNG----SGLSRKAIMSEIDKSLKRLETDYVDLYIIH--------------RWDYDT 135
Cdd:PRK10625 73 LAKRGSREKLIIASKVSGPSRNNDKGirpnQALDRKNIREALHDSLKRLQTDYLDLYQVHwpqrptncfgklgySWTDSA 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 136 PIE---ETMEALHDVVKAGKARYIGASAMYAWQFQKALHVAEKNGWTKFVSMQNHLNLIYREGEREMLPLCKEEKIGVTP 212
Cdd:PRK10625 153 PAVsllETLDALAEQQRAGKIRYIGVSNETAFGVMRYLHLAEKHDLPRIVTIQNPYSLLNRSFEVGLAEVSQYEGVELLA 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 213 YSPLASGRLTRDWSVTTHRSETDQIQKSKYDA-TADSDRLVVERVASIAEKHGIPRTHIALAWLLQKEPVTAPIIGATKT 291
Cdd:PRK10625 233 YSCLAFGTLTGKYLNGAKPAGARNTLFSRFTRySGEQTQKAVAAYVDIAKRHGLDPAQMALAFVRRQPFVASTLLGATTM 312
|
330 340
....*....|....*....|....
gi 1267806617 292 SHLENAVDALSIKLTPEEIAFLED 315
Cdd:PRK10625 313 EQLKTNIESLHLTLSEEVLAEIEA 336
|
|
| AKR_unchar |
cd19100 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
3-299 |
9.99e-53 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381326 [Multi-domain] Cd Length: 238 Bit Score: 173.44 E-value: 9.99e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 3 YVKLGNTGLDVSRLCLGCMGFGDankwlhqwvLNEDDSRIVIKEALDLGINFFDTANVYslGTSEEYLGRALKDYanRDE 82
Cdd:cd19100 1 YRRLGRTGLKVSRLGFGGGPLGR---------LSQEEAAAIIRRALDLGINYFDTAPSY--GDSEEKIGKALKGR--RDK 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 83 VVIATKVHGQmhkgpngsglSRKAIMSEIDKSLKRLETDYVDLYIIH----RWDYDTPIEE--TMEALHDVVKAGKARYI 156
Cdd:cd19100 68 VFLATKTGAR----------DYEGAKRDLERSLKRLGTDYIDLYQLHavdtEEDLDQVFGPggALEALLEAKEEGKIRFI 137
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 157 GASAMYAWQFQKALhvaeKNGWtkFVSMQNHLNLIYREGEREM---LPLCKEEKIGVTPYSPLASGRLTRDwsvtthrse 233
Cdd:cd19100 138 GISGHSPEVLLRAL----ETGE--FDVVLFPINPAGDHIDSFReelLPLAREKGVGVIAMKVLAGGRLLSG--------- 202
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1267806617 234 tdqiqkskydatadsdrlvveRVASIAEkhgiprthiALAWLLQKEPVTAPIIGATKTSHLENAVD 299
Cdd:cd19100 203 ---------------------DPLDPEQ---------ALRYALSLPPVDVVIVGMDSPEELDENLA 238
|
|
| AKR_AKR13A1 |
cd19144 |
AKR13A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto reductase YakC ... |
1-324 |
3.12e-51 |
|
AKR13A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto reductase YakC is a founding member of aldo-keto reductase family 13 member A1 (AKR13A1). It catalyzes the reversible reduction of ketones to the respective alcohols using NADP(+) as a hydride donor.
Pssm-ID: 381370 [Multi-domain] Cd Length: 323 Bit Score: 172.24 E-value: 3.12e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 1 MKYVKLGNTGLDVSRLCLGCMGFGDankwLHQWVLNEDDSRIVIKEALDLGINFFDTANVYslGTSEEYLGRALK-DYAN 79
Cdd:cd19144 1 IPTRTLGRNGPSVPALGFGAMGLSA----FYGPPKPDEERFAVLDAAFELGCTFWDTADIY--GDSEELIGRWFKqNPGK 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 80 RDEVVIATKVHGQMhKGPNGSGLSRKA---IMSEIDKSLKRLETDYVDLYIIHRWDYDTPIEETMEALHDVVKAGKARYI 156
Cdd:cd19144 75 REKIFLATKFGIEK-NVETGEYSVDGSpeyVKKACETSLKRLGVDYIDLYYQHRVDGKTPIEKTVAAMAELVQEGKIKHI 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 157 GASAMYAWQFQKALHV-------AEKNGWTkfvsmqnhlnLIYREGEREMLPLCKEEKIGVTPYSPLASGRLTRDWSVTT 229
Cdd:cd19144 154 GLSECSAETLRRAHAVhpiaavqIEYSPFS----------LDIERPEIGVLDTCRELGVAIVAYSPLGRGFLTGAIRSPD 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 230 HRSETD-QIQKSKYDATADSDRL-VVERVASIAEKHGIPRTHIALAWLLQKEPVTAPIIGATKTSHLENAVDALSIKLTP 307
Cdd:cd19144 224 DFEEGDfRRMAPRFQAENFPKNLeLVDKIKAIAKKKNVTAGQLTLAWLLAQGDDIIPIPGTTKLKRLEENLGALKVKLTE 303
|
330
....*....|....*..
gi 1267806617 308 EEIAFLEDPYVPHPIVG 324
Cdd:cd19144 304 EEEKEIREIAEEAEVVG 320
|
|
| AKR_AKR14A1 |
cd19150 |
Escherichia coli L-glyceraldehyde 3-phosphate reductase (GPR/YghZ/AKR14A1) and similar ... |
2-311 |
5.60e-51 |
|
Escherichia coli L-glyceraldehyde 3-phosphate reductase (GPR/YghZ/AKR14A1) and similar proteins; Escherichia coli L-glyceraldehyde 3-phosphate reductase (GPR/YghZ), also called GAP reductase, is a founding member of aldo-keto reductase family 14 member A1 (AKR14A1). It catalyzes the stereospecific, NADPH-dependent reduction of L-glyceraldehyde 3-phosphate (L-GAP). It is also involved in the stress response as a methylglyoxal reductase which converts the toxic metabolite methylglyoxal to acetol in vitro and in vivo.
Pssm-ID: 381376 [Multi-domain] Cd Length: 309 Bit Score: 171.10 E-value: 5.60e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 2 KYVKLGNTGLDVSRLCLGCM-GFGDANKWLHQwvlneddsRIVIKEALDLGINFFDTANVYS--LGTSEEYLGRALK-DY 77
Cdd:cd19150 1 QYRRCGKSGLKLPALSLGLWhNFGDDTPLETQ--------RAILRTAFDLGITHFDLANNYGppPGSAEENFGRILReDF 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 78 AN-RDEVVIATKVHGQMHKGPNGSGLSRKAIMSEIDKSLKRLETDYVDLYIIHRWDYDTPIEETMEALHDVVKAGKARYI 156
Cdd:cd19150 73 AGyRDELIISTKAGYDMWPGPYGEWGSRKYLLASLDQSLKRMGLDYVDIFYSHRFDPDTPLEETMGALDHAVRSGKALYV 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 157 GASAMYAWQFQKALHVAEKNGwTKFVSMQNHLNLIYREGER-EMLPLCKEEKIGVTPYSPLASGRLTRDW-----SVTTH 230
Cdd:cd19150 153 GISSYSPERTREAAAILRELG-TPLLIHQPSYNMLNRWVEEsGLLDTLQELGVGCIAFTPLAQGLLTDKYlngipEGSRA 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 231 RSETDQIQKSKYDATADSDRLVVErvasIAEKHGIPRTHIALAWLLQKEPVTAPIIGATKTSHLENAVDAL-SIKLTPEE 309
Cdd:cd19150 232 SKERSLSPKMLTEANLNSIRALNE----IAQKRGQSLAQMALAWVLRDGRVTSALIGASRPEQLEENVGALdNLTFSADE 307
|
..
gi 1267806617 310 IA 311
Cdd:cd19150 308 LA 309
|
|
| PRK09912 |
PRK09912 |
L-glyceraldehyde 3-phosphate reductase; Provisional |
1-311 |
2.37e-50 |
|
L-glyceraldehyde 3-phosphate reductase; Provisional
Pssm-ID: 182140 [Multi-domain] Cd Length: 346 Bit Score: 170.56 E-value: 2.37e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 1 MKYVKLGNTGLDVSRLCLGCM-GFGDANKWlhqwvlneDDSRIVIKEALDLGINFFDTANVYS--LGTSEEYLGRALKD- 76
Cdd:PRK09912 13 MQYRYCGKSGLRLPALSLGLWhNFGHVNAL--------ESQRAILRKAFDLGITHFDLANNYGppPGSAEENFGRLLREd 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 77 -YANRDEVVIATKVHGQMHKGPNGSGLSRKAIMSEIDKSLKRLETDYVDLYIIHRWDYDTPIEETMEALHDVVKAGKARY 155
Cdd:PRK09912 85 fAAYRDELIISTKAGYDMWPGPYGSGGSRKYLLASLDQSLKRMGLEYVDIFYSHRVDENTPMEETASALAHAVQSGKALY 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 156 IGASAMYAWQFQKALHVAEKngWT-KFVSMQNHLNLIYREGERE-MLPLCKEEKIGVTPYSPLASGRLTRDW-----SVT 228
Cdd:PRK09912 165 VGISSYSPERTQKMVELLRE--WKiPLLIHQPSYNLLNRWVDKSgLLDTLQNNGVGCIAFTPLAQGLLTGKYlngipQDS 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 229 THRSETDQI----QKSKYDATADSDRLVVErvasIAEKHGIPRTHIALAWLLQKEPVTAPIIGATKTSHLENAVDALS-I 303
Cdd:PRK09912 243 RMHREGNKVrgltPKMLTEANLNSLRLLNE----MAQQRGQSMAQMALSWLLKDERVTSVLIGASRAEQLEENVQALNnL 318
|
....*...
gi 1267806617 304 KLTPEEIA 311
Cdd:PRK09912 319 TFSTEELA 326
|
|
| AKR_galDH |
cd19163 |
L-galactose dehydrogenase (L-galDH) and similar proteins; L-galDH (EC 1.1.1.316), also called ... |
1-311 |
6.72e-50 |
|
L-galactose dehydrogenase (L-galDH) and similar proteins; L-galDH (EC 1.1.1.316), also called L-galactose 1-dehydrogenase, catalyzes the oxidation of L-galactose to L-galactono-1,4-lactone in the presence of NAD(+). It uses NAD(+) as a hydrogen acceptor much more efficiently than NADP(+).
Pssm-ID: 381389 [Multi-domain] Cd Length: 293 Bit Score: 167.73 E-value: 6.72e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 1 MKYVKLGNTGLDVSRLCLGCMGFGDAnkwlhQWVLNEDDSRIVIKEALDLGINFFDTANVYSLGTSEEYLGRALKDyANR 80
Cdd:cd19163 1 MKYRKLGKTGLKVSKLGFGASPLGGV-----FGPVDEEEAIRTVHEALDSGINYIDTAPWYGQGRSETVLGKALKG-IPR 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 81 DEVVIATKVhGQMhkGPNGSGL---SRKAIMSEIDKSLKRLETDYVDLYIIHRWDY----DTPIEETMEALHDVVKAGKA 153
Cdd:cd19163 75 DSYYLATKV-GRY--GLDPDKMfdfSAERITKSVEESLKRLGLDYIDIIQVHDIEFapslDQILNETLPALQKLKEEGKV 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 154 RYIGASAmYAWQFQKAlhVAEKNGWTKFVSMQ-NHLNLIYREgEREMLPLCKEEKIGVTPYSPLASGRLT----RDWsvt 228
Cdd:cd19163 152 RFIGITG-YPLDVLKE--VLERSPVKIDTVLSyCHYTLNDTS-LLELLPFFKEKGVGVINASPLSMGLLTergpPDW--- 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 229 tHRSeTDQIQKskydatadsdrlVVERVASIAEKHGIPRTHIALAWLLQKEPVTAPIIGATKTSHLENAVDALSIKLTPE 308
Cdd:cd19163 225 -HPA-SPEIKE------------ACAKAAAYCKSRGVDISKLALQFALSNPDIATTLVGTASPENLRKNLEAAEEPLDAH 290
|
...
gi 1267806617 309 EIA 311
Cdd:cd19163 291 LLA 293
|
|
| AKR_unchar |
cd19103 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
35-315 |
1.24e-49 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381329 [Multi-domain] Cd Length: 299 Bit Score: 167.13 E-value: 1.24e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 35 LNEDDSRIVIKEALDLGINFFDTANVYSLGTSEEYLGRALKDYAnRDEVVIATKVhgqmhkGPNGSGLSRKAIMSEIDKS 114
Cdd:cd19103 29 LDEDTLKAVFDKAMAAGLNLWDTAAVYGMGASEKILGEFLKRYP-REDYIISTKF------TPQIAGQSADPVADMLEGS 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 115 LKRLETDYVDLYIIHRwdyDTPIEETMEALHDVVKAGKARYIGASAMYAWQFQKALHVAEKNGWtKFVSMQNHLNLIYRE 194
Cdd:cd19103 102 LARLGTDYIDIYWIHN---PADVERWTPELIPLLKSGKVKHVGVSNHNLAEIKRANEILAKAGV-SLSAVQNHYSLLYRS 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 195 GERE-MLPLCKEEKIGVTPYSPLASGRLTrDWSVTTHRSETDQIQKSKYDATADSDRLVVERVASIAEKHGIPRTHIALA 273
Cdd:cd19103 178 SEEAgILDYCKENGITFFAYMVLEQGALS-GKYDTKHPLPEGSGRAETYNPLLPQLEELTAVMAEIGAKHGASIAQVAIA 256
|
250 260 270 280
....*....|....*....|....*....|....*....|..
gi 1267806617 274 WLLQKEpvTAPIIGATKTSHLENAVDALSIKLTPEEIAFLED 315
Cdd:cd19103 257 WAIAKG--TTPIIGVTKPHHVEDAARAASITLTDDEIKELEQ 296
|
|
| ARA1 |
COG0656 |
Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, ... |
33-311 |
2.37e-48 |
|
Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism];
Pssm-ID: 440421 [Multi-domain] Cd Length: 259 Bit Score: 162.53 E-value: 2.37e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 33 WVLNEDDSRIVIKEALDLGINFFDTANVYSlgtSEEYLGRALKDY-ANRDEVVIATKVHGQMHkgpngsglSRKAIMSEI 111
Cdd:COG0656 13 WQLPGEEAAAAVRTALEAGYRHIDTAAMYG---NEEGVGEAIAASgVPREELFVTTKVWNDNH--------GYDDTLAAF 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 112 DKSLKRLETDYVDLYIIHrWDYDTPIEETMEALHDVVKAGKARYIGASAMYAWQFQKALHVAEkngwTKFVSMQNHLNLI 191
Cdd:COG0656 82 EESLERLGLDYLDLYLIH-WPGPGPYVETWRALEELYEEGLIRAIGVSNFDPEHLEELLAETG----VKPAVNQVELHPY 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 192 YRegEREMLPLCKEEKIGVTPYSPLASGRLTRDwsvtthrsetdqiqkskydatadsdrlvvERVASIAEKHGIPRTHIA 271
Cdd:COG0656 157 LQ--QRELLAFCREHGIVVEAYSPLGRGKLLDD-----------------------------PVLAEIAEKHGKTPAQVV 205
|
250 260 270 280
....*....|....*....|....*....|....*....|.
gi 1267806617 272 LAWLLQKEpvTAPIIGATKTSHL-ENAvDALSIKLTPEEIA 311
Cdd:COG0656 206 LRWHLQRG--VVVIPKSVTPERIrENL-DAFDFELSDEDMA 243
|
|
| AKR_AKR8A1-2 |
cd19077 |
AKR8A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe PLR and PLR2 are founding ... |
9-311 |
2.24e-47 |
|
AKR8A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe PLR and PLR2 are founding members of aldo-keto reductase family 8 member A1-2 (AKR8A1-2), respectively. PLR (EC 1.1.1.65), also called PL reductase (PL-red), catalyzes the reduction of pyridoxal (PL) with NADPH and oxidation of pyridoxine (PN) with NADP(+).
Pssm-ID: 381303 [Multi-domain] Cd Length: 302 Bit Score: 161.64 E-value: 2.24e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 9 TGLDVSRLCLGCMGF-GDANKwlhqwvlnEDDSRI--VIKEALDLGINFFDTANVYSLGT---SEEYLGRALKDY-ANRD 81
Cdd:cd19077 1 NGKLVGPIGLGLMGLtWRPNP--------TPDEEAfeTMKAALDAGSNLWNGGEFYGPPDphaNLKLLARFFRKYpEYAD 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 82 EVVIATKvhGQMHKGPNGSGLSRKAIMSEIDKSLKRL-ETDYVDLYIIHRWDYDTPIEETMEALHDVVKAGKARYIGASA 160
Cdd:cd19077 73 KVVLSVK--GGLDPDTLRPDGSPEAVRKSIENILRALgGTKKIDIFEPARVDPNVPIEETIKALKELVKEGKIRGIGLSE 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 161 MYAWQFQKALHVAekngwtKFVSMQNHLNLIYRE-GEREMLPLCKEEKIGVTPYSPLASGRLTRDWSVTT------HRSE 233
Cdd:cd19077 151 VSAETIRRAHAVH------PIAAVEVEYSLFSREiEENGVLETCAELGIPIIAYSPLGRGLLTGRIKSLAdipegdFRRH 224
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1267806617 234 TDQIQKSKYDATADsdrlVVERVASIAEKHGIPRTHIALAWLL-QKEPVTAPIIGATKTSHLENAVDALSIKLTPEEIA 311
Cdd:cd19077 225 LDRFNGENFEKNLK----LVDALQELAEKKGCTPAQLALAWILaQSGPKIIPIPGSTTLERVEENLKAANVELTDEELK 299
|
|
| AKR_unchar |
cd19104 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
2-317 |
3.68e-47 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381330 [Multi-domain] Cd Length: 321 Bit Score: 161.66 E-value: 3.68e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 2 KYVKLGNTGLDVSRLCLGCMGFGDAnkWLHQwvlNEDDSRIVIKEALDLGINFFDTANVYSLGTSEEYLGRALKDyaNRD 81
Cdd:cd19104 1 KYRRFGRTGLKVSELTFGGGGIGGL--MGRT---TREEQIAAVRRALDLGINFFDTAPSYGDGKSEENLGRALKG--LPA 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 82 EVVIATKVH-GQMHKGPNGSGLSRKaimseIDKSLKRLETDYVDLYIIH-------RWDYDTPIE--------ETMEALH 145
Cdd:cd19104 74 GPYITTKVRlDPDDLGDIGGQIERS-----VEKSLKRLKRDSVDLLQLHnrigderDKPVGGTLSttdvlglgGVADAFE 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 146 DVVKAGKARYIGASamyAWQFQKALHVAEKNGwtKFVSMQNHLNLI--------YREGE----REMLPLCKEEKIGVTPY 213
Cdd:cd19104 149 RLRSEGKIRFIGIT---GLGNPPAIRELLDSG--KFDAVQVYYNLLnpsaaearPRGWSaqdyGGIIDAAAEHGVGVMGI 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 214 SPLASGRLTRdwSVTTHRSETDQIQKskyDATADSDRlvVERVASIAEKHGIPRTHIALAWLLQKEPVTAPIIGATKTSH 293
Cdd:cd19104 224 RVLAAGALTT--SLDRGREAPPTSDS---DVAIDFRR--AAAFRALAREWGETLAQLAHRFALSNPGVSTVLVGVKNREE 296
|
330 340
....*....|....*....|....*
gi 1267806617 294 LENAVDALSI-KLTPEEIAFLEDPY 317
Cdd:cd19104 297 LEEAVAAEAAgPLPAENLARLEALW 321
|
|
| AKR_AKR15A-like |
cd19090 |
AKR15A family of aldo-keto reductase and similar proteins; The AKR15 family includes ... |
14-310 |
7.17e-47 |
|
AKR15A family of aldo-keto reductase and similar proteins; The AKR15 family includes Microbacterium luteolum pyridoxal 4-dehydrogenase (PLD), Pseudomonas sp. D-threo-aldose 1-dehydrogenase (FDH) and similar proteins. PLD (EC1.1.1.107) catalyzes irreversible oxidation of pyridoxal. FDH (EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose and, to a much lesser degree, D-arabinose. FDH (EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose and, to a much lesser degree, D-arabinose. The family also includes L-galactose dehydrogenase (L-galDH) and D-arabinose 1-dehydrogenase (ARA2). L-galDH (EC 1.1.1.316), also called L-galactose 1-dehydrogenase, catalyzes the oxidation of L-galactose to L-galactono-1,4-lactone in the presence of NAD(+). It uses NAD(+) as a hydrogen acceptor much more efficiently than NADP(+). ARA2 (EC1.1.1.116), also called NAD(+)-specific D-arabinose dehydrogenase, catalyzes the the oxidation of D-arabinose to D-arabinono-1,4-lactone in the presence of NAD(+).
Pssm-ID: 381316 [Multi-domain] Cd Length: 278 Bit Score: 159.64 E-value: 7.17e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 14 SRLCLGCMGFGDANKwlhqwVLNEDDSRIVIKEALDLGINFFDTANVYslGTSEEYLGRALKDYAnRDEVVIATKVhgqm 93
Cdd:cd19090 1 SALGLGTAGLGGVFG-----GVDDDEAVATIRAALDLGINYIDTAPAY--GDSEERLGLALAELP-REPLVLSTKV---- 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 94 hkGPNGSGL---SRKAIMSEIDKSLKRLETDYVDLYIIHR-----WDYDTPIEETMEALHDVVKAGKARYIGASAMYAWQ 165
Cdd:cd19090 69 --GRLPEDTadySADRVRRSVEESLERLGRDRIDLLMIHDpervpWVDILAPGGALEALLELKEEGLIKHIGLGGGPPDL 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 166 FQKALhvaeKNGWTKFVSMQNHLNLIYREGEREMLPLCKEEKIGVTPYSPLASGRLTRDwsvtthrsETDQIQKSKYDAT 245
Cdd:cd19090 147 LRRAI----ETGDFDVVLTANRYTLLDQSAADELLPAAARHGVGVINASPLGMGLLAGR--------PPERVRYTYRWLS 214
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1267806617 246 ADS-DRLvvERVASIAEKHGIPRTHIALAWLLQKEPVTAPIIGATKTSHLENAVDALSIKLtPEEI 310
Cdd:cd19090 215 PELlDRA--KRLYELCDEHGVPLPALALRFLLRDPRISTVLVGASSPEELEQNVAAAEGPL-PEEL 277
|
|
| AKR_AKR3F2_3 |
cd19073 |
Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB), Sinorhizobium meliloti ... |
33-311 |
9.44e-46 |
|
Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB), Sinorhizobium meliloti isatin reductase and similar proteins; Escherichia coli DkgB/YafB (EC 1.1.1.346), also called 2,5-didehydrogluconate reductase (2-dehydro-L-gulonate-forming), or 2,5-DKG reductase B, or 2,5-DKGR B, or 25DKGR-B, is a founding member of aldo-keto reductase family 3 member F2 (AKR3F2). It catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG). Sinorhizobium meliloti isatin reductase is a founding member of aldo-keto reductase family 3 member F3 (AKR3F3). It is a aldo/keto reductase family oxidoreductase.
Pssm-ID: 381299 [Multi-domain] Cd Length: 243 Bit Score: 155.51 E-value: 9.44e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 33 WVLNEDDSRIVIKEALDLGINFFDTANVYSlgtSEEYLGRALKDY-ANRDEVVIATKVhgqmhkgpNGSGLSRKAIMSEI 111
Cdd:cd19073 9 WQLRGDDCANAVKEALELGYRHIDTAEIYN---NEAEVGEAIAESgVPREDLFITTKV--------WRDHLRPEDLKKSV 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 112 DKSLKRLETDYVDLYIIHRWDYDTPIEETMEALHDVVKAGKARYIGASAMYAWQFQKALHVAEKNGWTKFVSMQNHLNli 191
Cdd:cd19073 78 DRSLEKLGTDYVDLLLIHWPNPTVPLEETLGALKELKEAGKVKSIGVSNFTIELLEEALDISPLPIAVNQVEFHPFLY-- 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 192 yregEREMLPLCKEEKIGVTPYSPLASGrltrdwsvtthrsetdqiqkskydatadsDRLVVERVASIAEKHGIPRTHIA 271
Cdd:cd19073 156 ----QAELLEYCRENDIVITAYSPLARG-----------------------------EVLRDPVIQEIAEKYDKTPAQVA 202
|
250 260 270 280
....*....|....*....|....*....|....*....|
gi 1267806617 272 LAWLLQKEPVTAPiiGATKTSHLENAVDALSIKLTPEEIA 311
Cdd:cd19073 203 LRWLVQKGIVVIP--KASSEDHLKENLAIFDWELTSEDVA 240
|
|
| AKR_YeaE |
cd19138 |
Escherichia coli YeaE and similar proteins; Escherichia coli YeaE is the prototype of this ... |
2-314 |
2.89e-45 |
|
Escherichia coli YeaE and similar proteins; Escherichia coli YeaE is the prototype of this family. It acts as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.
Pssm-ID: 381364 [Multi-domain] Cd Length: 266 Bit Score: 155.10 E-value: 2.89e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 2 KYVKLGnTGLDVSRLCLGCMGFG-DANKWlhqwvlneDDSRIVIKEALDLGINFFDTANVYSLGTSEEYLGRALKDYanR 80
Cdd:cd19138 1 RTVTLP-DGTKVPALGQGTWYMGeDPAKR--------AQEIEALRAGIDLGMTLIDTAEMYGDGGSEELVGEAIRGR--R 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 81 DEVVIATKVHgqmhkgPngSGLSRKAIMSEIDKSLKRLETDYVDLYIIHrWDYDTPIEETMEALHDVVKAGKARYIGASA 160
Cdd:cd19138 70 DKVFLVSKVL------P--SNASRQGTVRACERSLRRLGTDYLDLYLLH-WRGGVPLAETVAAMEELKKEGKIRAWGVSN 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 161 MYAWQFQKALHVAEKNgwtKFVSMQNHLNLIYREGEREMLPLCKEEKIGVTPYSPLASGRLTRdwsvtthrsetdqiqks 240
Cdd:cd19138 141 FDTDDMEELWAVPGGG---NCAANQVLYNLGSRGIEYDLLPWCREHGVPVMAYSPLAQGGLLR----------------- 200
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1267806617 241 kydatadSDRLVVERVASIAEKHGIPRTHIALAWLLQKEPVTApIIGATKTSHLENAVDALSIKLTPEEIAFLE 314
Cdd:cd19138 201 -------RGLLENPTLKEIAARHGATPAQVALAWVLRDGNVIA-IPKSGSPEHARENAAAADLELTEEDLAELD 266
|
|
| AKR_PA4992-like |
cd19095 |
Pseudomona aeruginosa PA4992 and similar proteins; Pseudomona aeruginosa PA4992 is the ... |
14-300 |
7.36e-45 |
|
Pseudomona aeruginosa PA4992 and similar proteins; Pseudomona aeruginosa PA4992 is the prototype of this family. It is a putative aldo-keto reductase that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.
Pssm-ID: 381321 [Multi-domain] Cd Length: 253 Bit Score: 153.54 E-value: 7.36e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 14 SRLCLGCMGFGDankwlHQWVLNEDDSRIVIKEALDLGINFFDTANVYslGTSEEYLGRALKDYAnRDEVVIATKVHGQM 93
Cdd:cd19095 1 SVLGLGTSGIGR-----VWGVPSEAEAARLLNTALDLGINLIDTAPAY--GRSEERLGRALAGLR-RDDLFIATKVGTHG 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 94 HKGPNGSGLSRKAIMSEIDKSLKRLETDYVDLYIIHRWDYDTPIEETMEALHDVVKAGKARYIGASAMYAwqfqKALHVA 173
Cdd:cd19095 73 EGGRDRKDFSPAAIRASIERSLRRLGTDYIDLLQLHGPSDDELTGEVLETLEDLKAAGKVRYIGVSGDGE----ELEAAI 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 174 EKNGwtkFVSMQNHLNLIYREgEREMLPLCKEEKIGVTPYSPLASGRLTRDWSVTTHRSETDQIQKSKYDATADSdrlvv 253
Cdd:cd19095 149 ASGV---FDVVQLPYNVLDRE-EEELLPLAAEAGLGVIVNRPLANGRLRRRVRRRPLYADYARRPEFAAEIGGAT----- 219
|
250 260 270 280
....*....|....*....|....*....|....*....|....*..
gi 1267806617 254 ervasiaekhgipRTHIALAWLLQKEPVTAPIIGATKTSHLENAVDA 300
Cdd:cd19095 220 -------------WAQAALRFVLSHPGVSSAIVGTTNPEHLEENLAA 253
|
|
| AKR_AKR3F1 |
cd19137 |
Thermotoga maritime Tm1743 and similar proteins; Thermotoga maritime Tm1743 is a founding ... |
36-314 |
8.72e-40 |
|
Thermotoga maritime Tm1743 and similar proteins; Thermotoga maritime Tm1743 is a founding member of aldo-keto reductase family 3 member F1 (AKR3F1). It is a aldo/keto reductase family oxidoreductase.
Pssm-ID: 381363 [Multi-domain] Cd Length: 260 Bit Score: 140.40 E-value: 8.72e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 36 NEDDSRI-VIKEALDLGINFFDTANVYSLGTSEEYLGRALKDYAnRDEVVIATKVhgqMHkgpngSGLSRKAIMSEIDKS 114
Cdd:cd19137 23 SRDEEMVeLLKTAIELGYTHIDTAEMYGGGHTEELVGKAIKDFP-REDLFIVTKV---WP-----TNLRYDDLLRSLQNS 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 115 LKRLETDYVDLYIIHRWDYDTPIEETMEALHDVVKAGKARYIGASAMYAWQFQKALHVAEkngwTKFVSMQNHLNLIYRE 194
Cdd:cd19137 94 LRRLDTDYIDLYLIHWPNPNIPLEETLSAMAEGVRQGLIRYIGVSNFNRRLLEEAISKSQ----TPIVCNQVKYNLEDRD 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 195 -GEREMLPLCKEEKIGVTPYSPLASGRLtrdwsvtthrsetdqiqkskydatadsdrLVVERVASIAEKHGIPRTHIALA 273
Cdd:cd19137 170 pERDGLLEYCQKNGITVVAYSPLRRGLE-----------------------------KTNRTLEEIAKNYGKTIAQIALA 220
|
250 260 270 280
....*....|....*....|....*....|....*....|.
gi 1267806617 274 WLLQKEPVTApIIGATKTSHLENAVDALSIKLTPEEIAFLE 314
Cdd:cd19137 221 WLIQKPNVVA-IPKAGRVEHLKENLKATEIKLSEEEMKLLD 260
|
|
| AKR_AKR3F3 |
cd19140 |
Sinorhizobium meliloti isatin reductase and similar proteins; Sinorhizobium meliloti isatin ... |
20-311 |
1.01e-39 |
|
Sinorhizobium meliloti isatin reductase and similar proteins; Sinorhizobium meliloti isatin reductase is a founding member of aldo-keto reductase family 3 member F3 (AKR3F3). It is a aldo/keto reductase family oxidoreductase.
Pssm-ID: 381366 [Multi-domain] Cd Length: 253 Bit Score: 140.09 E-value: 1.01e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 20 CMGFGdankwlhQWVLNEDDSRIVIKEALDLGINFFDTANVYSlgtSEEYLGRALKDY-ANRDEVVIATKVHgqmhkgPN 98
Cdd:cd19140 10 ALGLG-------TYPLTGEECTRAVEHALELGYRHIDTAQMYG---NEAQVGEAIAASgVPRDELFLTTKVW------PD 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 99 GsgLSRKAIMSEIDKSLKRLETDYVDLYIIHRWDYDTPIEETMEALHDVVKAGKARYIGASAMYAWQFQKALHVAEkngw 178
Cdd:cd19140 74 N--YSPDDFLASVEESLRKLRTDYVDLLLLHWPNKDVPLAETLGALNEAQEAGLARHIGVSNFTVALLREAVELSE---- 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 179 TKFVSMQ--NHLNLiyreGEREMLPLCKEEKIGVTPYSPLASGRLTRDwsvtthrsetdqiqkskydatadsdrlvvERV 256
Cdd:cd19140 148 APLFTNQveYHPYL----DQRKLLDAAREHGIALTAYSPLARGEVLKD-----------------------------PVL 194
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*
gi 1267806617 257 ASIAEKHGIPRTHIALAWLLQKEPVTApIIGATKTSHLENAVDALSIKLTPEEIA 311
Cdd:cd19140 195 QEIGRKHGKTPAQVALRWLLQQEGVAA-IPKATNPERLEENLDIFDFTLSDEEMA 248
|
|
| AKR_AKR1-5-like |
cd19071 |
AKR1/2/3/4/5 family of aldo-keto reductase (AKR) and similar proteins; Aldo-keto reductases ... |
33-314 |
1.66e-38 |
|
AKR1/2/3/4/5 family of aldo-keto reductase (AKR) and similar proteins; Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. The family includes AKR1A/B/C/D/E/G/I, AKR2A/B/C/D/E, AKR3A/B/C/D/E/G, AKR4A/B/C, AKR5A/B/C/D/E/F/G/H, and similar proteins.
Pssm-ID: 381297 [Multi-domain] Cd Length: 251 Bit Score: 136.84 E-value: 1.66e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 33 WVLNEDDSRIVIKEALDLGINFFDTANVYSlgtSEEYLGRALKDYA-NRDEVVIATKVHGQMHkgpngsglSRKAIMSEI 111
Cdd:cd19071 9 YKLKPEETAEAVLAALEAGYRHIDTAAAYG---NEAEVGEAIRESGvPREELFITTKLWPTDH--------GYERVREAL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 112 DKSLKRLETDYVDLYIIH------RWDYDTPIEETMEALHDVVKAGKARYIGASAMYAWQFQKALHVAEkngwTKFVSMQ 185
Cdd:cd19071 78 EESLKDLGLDYLDLYLIHwpvpgkEGGSKEARLETWRALEELVDEGLVRSIGVSNFNVEHLEELLAAAR----IKPAVNQ 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 186 NHLNLIYRegEREMLPLCKEEKIGVTPYSPLASGRltrdwsvtthrsetdqiqkskydatadSDRLVVERVASIAEKHGI 265
Cdd:cd19071 154 IELHPYLQ--QKELVEFCKEHGIVVQAYSPLGRGR---------------------------RPLLDDPVLKEIAKKYGK 204
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 1267806617 266 PRTHIALAWLLQKEpvTAPIIGATKTSHLENAVDALSIKLTPEEIAFLE 314
Cdd:cd19071 205 TPAQVLLRWALQRG--VVVIPKSSNPERIKENLDVFDFELSEEDMAAID 251
|
|
| AKR_AKR6B1 |
cd19142 |
AKR6B family of aldo-keto reductase (AKR); Drosophila melanogaster Hk protein is a founding ... |
1-314 |
2.97e-38 |
|
AKR6B family of aldo-keto reductase (AKR); Drosophila melanogaster Hk protein is a founding member of aldo-keto reductase family 6 member B1 (AKR6B1). Hk protein, also called hyperkinetic, is a beta subunit of Shaker (Sh) K+ channels and shows high sequence homology to aldoketoreductase.
Pssm-ID: 381368 [Multi-domain] Cd Length: 325 Bit Score: 138.37 E-value: 2.97e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 1 MKYVKLGNTGLDVSRLCLGCM-GFGDAnkwlhqwvLNEDDSRIVIKEALDLGINFFDTANVYSLGTSEEYLGRALKDYA- 78
Cdd:cd19142 1 LKYRNLGKSGLRVSNVGLGTWsTFSTA--------ISEEQAEEIVTLAYENGINYFDTSDAFTSGQAETELGRILKKKGw 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 79 NRDEVVIATKVHgqMHKGPNGSGLSRKAIMSEIDKSLKRLETDYVDLYIIHRWDYDTPIEETMEALHDVVKAGKARYIGA 158
Cdd:cd19142 73 KRSSYIVSTKIY--WSYGSEERGLSRKHIIESVRASLRRLQLDYIDIVIIHKADPMCPMEEVVRAMSYLIDNGLIMYWGT 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 159 S--------AMY--AWQFQKALHVAEKngwtkfvsMQNHLNliYREG-EREMLPLCKEEKIGVTPYSPLASG-------- 219
Cdd:cd19142 151 SrwspveimEAFsiARQFNCPTPICEQ--------SEYHMF--CREKmELYMPELYNKVGVGLITWSPLSLGldpgisee 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 220 --RLTRDWSVTTHRSETDQIQKSKYDATADSDRLVVErVASIAEKHGIPRTHIALAWLLQKEPVTAPIIGATKTSHLENA 297
Cdd:cd19142 221 trRLVTKLSFKSSKYKVGSDGNGIHEETRRASHKLRE-LSLIAERLGCDLTQLLIAWSLKNENVQCVLIGASSLEQLYSQ 299
|
330
....*....|....*....
gi 1267806617 298 VDALSI--KLTPEEIAFLE 314
Cdd:cd19142 300 LNSLQLlpKLNSAVMEELE 318
|
|
| AKR_unchar |
cd19101 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
31-311 |
3.01e-37 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381327 [Multi-domain] Cd Length: 304 Bit Score: 135.03 E-value: 3.01e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 31 HQWVLNEDDSRIVIKEALDLGINFFDTANVYslGTSEEYLGRALKDYANRDEVVIATKVHGQMHKGPNGSGLSRKAIMSE 110
Cdd:cd19101 16 HGGIRDEDAAVRAMAAYVDAGLTTFDCADIY--GPAEELIGEFRKRLRRERDAADDVQIHTKWVPDPGELTMTRAYVEAA 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 111 IDKSLKRLETDYVDLYIIHRWDYDTP-IEETMEALHDVVKAGKARYIGASAMYAWQFQKALhvaeKNGwTKFVSMQNHLN 189
Cdd:cd19101 94 IDRSLKRLGVDRLDLVQFHWWDYSDPgYLDAAKHLAELQEEGKIRHLGLTNFDTERLREIL----DAG-VPIVSNQVQYS 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 190 LIYREGEREMLPLCKEEKIGVTPYSPLASGRLTRDW----SVTTHRSETDQIQKSK--YDATADSDRL--VVERVASIAE 261
Cdd:cd19101 169 LLDRRPENGMAALCEDHGIKLLAYGTLAGGLLSEKYlgvpEPTGPALETRSLQKYKlmIDEWGGWDLFqeLLRTLKAIAD 248
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 1267806617 262 KHGIPRTHIALAWLLQKEPVTAPIIGATKTSHLENAVDALSIKLTPEEIA 311
Cdd:cd19101 249 KHGVSIANVAVRWVLDQPGVAGVIVGARNSEHIDDNVRAFSFRLDDEDRA 298
|
|
| AKR_FDH |
cd19162 |
D-threo-aldose 1-dehydrogenase (FDH) and similar proteins; FDH (EC1.1.1.122), also called (2S, ... |
14-308 |
5.86e-37 |
|
D-threo-aldose 1-dehydrogenase (FDH) and similar proteins; FDH (EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose, and to a much lesser degree, D-arabinose.
Pssm-ID: 381388 [Multi-domain] Cd Length: 290 Bit Score: 134.02 E-value: 5.86e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 14 SRLCLGCMGFGDANKwlhqwvLNEDDSRIVIKEALDLGINFFDTANVYSLGTSEEYLGRALKDYAnRDEVVIATKVHGQM 93
Cdd:cd19162 1 PRLGLGAASLGNLAR------AGEDEAAATLDAAWDAGIRYFDTAPLYGLGLSERRLGAALARHP-RAEYVVSTKVGRLL 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 94 HKGPNGSG--------LSRKAIMSEIDKSLKRLETDYVDLYIIHRWD--YDTPIEETMEALHDVVKAGKARYIGASAMya 163
Cdd:cd19162 74 EPGAAGRPagadrrfdFSADGIRRSIEASLERLGLDRLDLVFLHDPDrhLLQALTDAFPALEELRAEGVVGAIGVGVT-- 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 164 wQFQKALHVAEKNGWtKFVSMQNHLNLIYREGEREMLPLCKEEKIGVTPYSPLASGRLTRDwSVTTHRSEtdqiqkskYD 243
Cdd:cd19162 152 -DWAALLRAARRADV-DVVMVAGRYTLLDRRAATELLPLCAAKGVAVVAAGVFNSGILATD-DPAGDRYD--------YR 220
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1267806617 244 ATADSDRLVVERVASIAEKHGIPRTHIALAWLLQKEPVTAPIIGATKTSHLENAVDALSIKLTPE 308
Cdd:cd19162 221 PATPEVLARARRLAAVCRRYGVPLPAAALQFPLRHPAVASVVVGAASPAELRDNLALLRTPIPAE 285
|
|
| Aldo_ket_red_shaker |
cd19141 |
Shaker potassium channel beta subunit (AKR6A) family of aldo-keto reductase (AKR); This family ... |
2-309 |
5.80e-36 |
|
Shaker potassium channel beta subunit (AKR6A) family of aldo-keto reductase (AKR); This family includes voltage-gated potassium channel subunits, beta-1 (KCAB1B), beta-2 (KCAB2B) and beta-3 (KCAB3B). KCAB1B and KCAB2B are cytoplasmic potassium channel subunits that modulate the characteristics of the channel-forming alpha-subunits. KCAB3B is an accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit.
Pssm-ID: 381367 [Multi-domain] Cd Length: 310 Bit Score: 131.80 E-value: 5.80e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 2 KYVKLGNTGLDVSrlclgCMGFGdankwlhQWV-----LNEDDSRIVIKEALDLGINFFDTANVYSLGTSEEYLGRALKD 76
Cdd:cd19141 1 PYRNLGKSGLRVS-----CLGLG-------TWVtfgsqISDEVAEELVTLAYENGINLFDTAEVYAAGKAEIVLGKILKK 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 77 YA-NRDEVVIATKVH--GqmhKGPNGSGLSRKAIMSEIDKSLKRLETDYVDLYIIHRWDYDTPIEETMEALHDVVKAGKA 153
Cdd:cd19141 69 KGwRRSSYVITTKIFwgG---KAETERGLSRKHIIEGLKASLERLQLEYVDIVFANRPDPNTPMEEIVRAFTHVINQGMA 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 154 RYIGASAMYAWQFQKALHVAEKNGWTKFVSMQNHLNLIYREGEREMLP-LCKEEKIGVTPYSPLASGRLTRDWSVTTH-- 230
Cdd:cd19141 146 MYWGTSRWSAMEIMEAYSVARQFNLIPPIVEQAEYHLFQREKVEMQLPeLFHKIGVGAMTWSPLACGILSGKYDDGVPey 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 231 -RSETDQIQKSKYDATADSDR---LVVERVASIAEKHGIPRTHIALAWLLQKEPVTAPIIGATKTSHLENAVDALSI--K 304
Cdd:cd19141 226 sRASLKGYQWLKEKILSEEGRrqqAKLKELQIIADRLGCTLPQLAIAWCLKNEGVSSVLLGASSTEQLYENLQAIQVlpK 305
|
....*
gi 1267806617 305 LTPEE 309
Cdd:cd19141 306 LTPNI 310
|
|
| AKR_KCAB3B_AKR6A9-like |
cd19160 |
voltage-gated potassium channel subunit beta-3 (KCAB3B) and similar proteins; KCAB3B from Homo ... |
1-310 |
2.15e-35 |
|
voltage-gated potassium channel subunit beta-3 (KCAB3B) and similar proteins; KCAB3B from Homo sapiens, Rattus norvegicus, and Mus musculus, are founding members of aldo-keto reductase family 6 member A9 (AKR6A9), A12 (AKR6A12), A14 (AKR6A14), respectively. KCAB3B, also called Shaker channel b-subunit 3 (Kvb3), K(+) channel subunit beta-3, or Kv-beta-3, is an accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. It alters the functional properties of Kv1.5.
Pssm-ID: 381386 [Multi-domain] Cd Length: 325 Bit Score: 130.88 E-value: 2.15e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 1 MKYVKLGNTGLDVSrlclgCMGFGdankwlhQWV-----LNEDDSRIVIKEALDLGINFFDTANVYSLGTSEEYLGRALK 75
Cdd:cd19160 3 MKYRNLGKSGLRVS-----CLGLG-------TWVtfgsqISDETAEDLLTVAYEHGVNLFDTAEVYAAGKAERTLGNILK 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 76 DYA-NRDEVVIATKVH--GQmhkGPNGSGLSRKAIMSEIDKSLKRLETDYVDLYIIHRWDYDTPIEETMEALHDVVKAGK 152
Cdd:cd19160 71 SKGwRRSSYVVTTKIYwgGQ---AETERGLSRKHIIEGLRGSLDRLQLEYVDIVFANRSDPNSPMEEIVRAMTYVINQGM 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 153 ARYIGASAMYAWQFQKALHVAEKNGWTKFVSMQNHLNLIYREGEREMLP-LCKEEKIGVTPYSPLASGRLTR-------- 223
Cdd:cd19160 148 AMYWGTSRWSAMEIMEAYSVARQFNLIPPVCEQAEYHLFQREKVEMQLPeLYHKIGVGSVTWSPLACGLITGkydgrvpd 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 224 ---------DWSVTTHRSETDQIQKSKydatadsdrlvVERVASIAEKHGIPRTHIALAWLLQKEPVTAPIIGATKTSHL 294
Cdd:cd19160 228 tcraavkgyQWLKEKVQSEEGKKQQAK-----------VKELHPIADRLGCTVAQLAIAWCLRSEGVSSVLLGVSSAEQL 296
|
330
....*....|....*...
gi 1267806617 295 ENAVDALSI--KLTPEEI 310
Cdd:cd19160 297 IENLGSIQVlsQLTPQTV 314
|
|
| AKR_AKR3C2-3 |
cd19120 |
Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase, Candida parapsilosis ... |
22-311 |
4.84e-35 |
|
Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase, Candida parapsilosis NADPH-dependent conjugated polyketone reductase C2 (CPR), and similar proteins; Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase (EC 1.1.1.190/EC 1.1.1.191) and Candida parapsilosis NADPH-dependent CPR (EC 1.1.1.358/EC 1.1.1.168) are founding members of aldo-keto reductase family 3 member C2 (AKR3C2) and C3 (AKR3C3), respectively. Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase catalyzes the conversion from (Indol-3-yl)ethanol to (indol-3-yl)acetaldehyde in a NAD/NADP-dependent manner. CPR, also called 2-dehydropantolactone reductase, or 2-dehydropantolactone reductase (A-specific), or ketopantoyl-lactone reductase, acts as a NADPH-dependent conjugated polyketone reductase with broad substrate specificity and strict stereospecificity. It reduces ketopantoyl lactone and isatin.
Pssm-ID: 381346 [Multi-domain] Cd Length: 269 Bit Score: 128.12 E-value: 4.84e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 22 GFGDANKWLhQWVLNEDDSRIV--IKEALDLGINFFDTANVYSlgtSEEYLGRALKDY-ANRDEVVIATKVHGQMhkgpn 98
Cdd:cd19120 8 AFGTGTAWY-KSGDDDIQRDLVdsVKLALKAGFRHIDTAEMYG---NEKEVGEALKESgVPREDLFITTKVSPGI----- 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 99 gsglsrKAIMSEIDKSLKRLETDYVDLYIIH--RWDY--DTPIEETMEALHDVVKAGKARYIGASAMYAWQFQKALHVAe 174
Cdd:cd19120 79 ------KDPREALRKSLAKLGVDYVDLYLIHspFFAKegGPTLAEAWAELEALKDAGLVRSIGVSNFRIEDLEELLDTA- 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 175 kngwtKFVSMQNHLNL---IYREGErEMLPLCKEEKIGVTPYSPLASgrLTRdwsvtthrsetdqiqkskydataDSDRL 251
Cdd:cd19120 152 -----KIKPAVNQIEFhpyLYPQQP-ALLEYCREHGIVVSAYSPLSP--LTR-----------------------DAGGP 200
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 252 VVERVASIAEKHGIPRTHIALAWLLQKEpvTAPIIGATKTSHLENAVDALSIKLTPEEIA 311
Cdd:cd19120 201 LDPVLEKIAEKYGVTPAQVLLRWALQKG--IVVVTTSSKEERMKEYLEAFDFELTEEEVE 258
|
|
| AKR_KCAB2B_AKR6A1-like |
cd19158 |
voltage-gated potassium channel subunit beta-2 (KCAB2B) and similar proteins; KCAB2B from Bos ... |
1-303 |
4.02e-34 |
|
voltage-gated potassium channel subunit beta-2 (KCAB2B) and similar proteins; KCAB2B from Bos taurus, Rattus norvegicus, Mus musculus, Homo sapiens, and Oryctolagus cuniculus, are founding members of aldo-keto reductase family 6 member A1 (AKR6A1), A2 (AKR6A2), A4 (AKR6A4), A5 (AKR6A5), and A6 (AKR6A6), respectively. KCAB2B, also called Shaker channel b-subunit 2 (Kvb2), or K(+) channel subunit beta-2, or Kv-beta-2, or Kvbeta2, is a cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits. It may be involved in the regulation of nerve signaling, and prevents neuronal hyperexcitability.
Pssm-ID: 381384 [Multi-domain] Cd Length: 324 Bit Score: 127.51 E-value: 4.02e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 1 MKYVKLGNTGLDVSrlclgCMGFGdankwlhQWV-----LNEDDSRIVIKEALDLGINFFDTANVYSLGTSEEYLGRALK 75
Cdd:cd19158 1 QFYRNLGKSGLRVS-----CLGLG-------TWVtfggqITDEMAEHLMTLAYDNGINLFDTAEVYAAGKAEVVLGNIIK 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 76 DYA-NRDEVVIATKVHGQmHKGPNGSGLSRKAIMSEIDKSLKRLETDYVDLYIIHRWDYDTPIEETMEALHDVVKAGKAR 154
Cdd:cd19158 69 KKGwRRSSLVITTKIFWG-GKAETERGLSRKHIIEGLKASLERLQLEYVDVVFANRPDPNTPMEETVRAMTHVINQGMAM 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 155 YIGASAMYAWQFQKALHVAEKNGWTKFVSMQNHLNLIYREGEREMLP-LCKEEKIGVTPYSPLASGRLTRDWSVTT---H 230
Cdd:cd19158 148 YWGTSRWSSMEIMEAYSVARQFNLIPPICEQAEYHMFQREKVEVQLPeLFHKIGVGAMTWSPLACGIVSGKYDSGIppyS 227
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1267806617 231 RSETDQIQKSKYDATADSDR---LVVERVASIAEKHGIPRTHIALAWLLQKEPVTAPIIGATKTSHLENAVDALSI 303
Cdd:cd19158 228 RASLKGYQWLKDKILSEEGRrqqAKLKELQAIAERLGCTLPQLAIAWCLRNEGVSSVLLGASNAEQLMENIGAIQV 303
|
|
| AKR_KCAB1B_AKR6A3-like |
cd19159 |
voltage-gated potassium channel subunit beta-1 (KCAB1B) and similar proteins; KCAB1B from Homo ... |
1-303 |
1.10e-33 |
|
voltage-gated potassium channel subunit beta-1 (KCAB1B) and similar proteins; KCAB1B from Homo sapiens, Mus musculus, Mustela putorius, Rattus norvegicus, and Kvb1.1, Kvb1.2 from Oryctolagus cuniculus, are founding members of aldo-keto reductase family 6 member A3 (AKR6A3), A8 (AKR6A8), A10a (AKR6A10a), A13 (AKR6A13), A7 (AKR6A7) and A10b (AKR6A10b), respectively. KCAB1B, also called Shaker channel b-subunit 1(Kvb1), K(+) channel subunit beta-1, or Kv-beta-1, is a cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits. It modulates action potentials via its effect on the pore-forming alpha subunits.
Pssm-ID: 381385 [Multi-domain] Cd Length: 323 Bit Score: 126.31 E-value: 1.10e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 1 MKYVKLGNTGLDVSrlclgCMGFGdankwlhQWV-----LNEDDSRIVIKEALDLGINFFDTANVYSLGTSEEYLGRALK 75
Cdd:cd19159 1 MKYRNLGKSGLRVS-----CLGLG-------TWVtfggqISDEVAERLMTIAYESGVNLFDTAEVYAAGKAEVILGSIIK 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 76 DYA-NRDEVVIATKVHGQmHKGPNGSGLSRKAIMSEIDKSLKRLETDYVDLYIIHRWDYDTPIEETMEALHDVVKAGKAR 154
Cdd:cd19159 69 KKGwRRSSLVITTKLYWG-GKAETERGLSRKHIIEGLKGSLQRLQLEYVDVVFANRPDSNTPMEEIVRAMTHVINQGMAM 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 155 YIGASAMYAWQFQKALHVAEKNGWTKFVSMQNHLNLIYREGEREMLP-LCKEEKIGVTPYSPLASGRLTRDWS---VTTH 230
Cdd:cd19159 148 YWGTSRWSAMEIMEAYSVARQFNMIPPVCEQAEYHLFQREKVEVQLPeLYHKIGVGAMTWSPLACGIISGKYGngvPESS 227
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1267806617 231 RSETDQIQKSKYDATADSDR---LVVERVASIAEKHGIPRTHIALAWLLQKEPVTAPIIGATKTSHLENAVDALSI 303
Cdd:cd19159 228 RASLKCYQWLKERIVSEEGRkqqNKLKDLSPIAERLGCTLPQLAVAWCLRNEGVSSVLLGSSTPEQLIENLGAIQV 303
|
|
| AKR_AKR15A |
cd19152 |
AKR15A family of aldo-keto reductase; The AKR15 family includes Microbacterium luteolum ... |
37-308 |
7.87e-33 |
|
AKR15A family of aldo-keto reductase; The AKR15 family includes Microbacterium luteolum pyridoxal 4-dehydrogenase (PLD), Pseudomonas sp. D-threo-aldose 1-dehydrogenase (FDH), and similar proteins. PLD (EC1.1.1.107) catalyzes irreversible oxidation of pyridoxal. FDH(EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose, and to a much lesser degree, D-arabinose. FDH (EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose, and to a much lesser degree, D-arabinose.
Pssm-ID: 381378 [Multi-domain] Cd Length: 308 Bit Score: 123.49 E-value: 7.87e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 37 EDDSRIVIKEALDLGINFFDTANVYSLGTSEEYLGRALKDYaNRDEVVIATKV----------HGQMHKGP-NGSGL--- 102
Cdd:cd19152 19 DEEAKATLVAAWDLGIRYFDTAPWYGAGLSEERLGAALREL-GREDYVISTKVgrllvplqevEPTFEPGFwNPLPFdav 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 103 ---SRKAIMSEIDKSLKRLETDYVDLYIIHRWDYDTPIEETME-----------ALHDVVKAGKARYIGAsAMYAWQF-Q 167
Cdd:cd19152 98 fdySYDGILRSIEDSLQRLGLSRIDLLSIHDPDEDLAGAESDEhfaqaikgafrALEELREEGVIKAIGL-GVNDWEViL 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 168 KALHVAEKNgwtkFVSMQNHLNLIYREGEREMLPLCKEEKIGVTPYSPLASGRLT-RDWSvtthrsetdqiqKSKYDATA 246
Cdd:cd19152 177 RILEEADLD----WVMLAGRYTLLDHSAARELLPECEKRGVKVVNAGPFNSGFLAgGDNF------------DYYEYGPA 240
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1267806617 247 DSDRLV-VERVASIAEKHGIPRTHIALAWLLQKEPVTAPIIGATKTSHLENAVDALSIKLTPE 308
Cdd:cd19152 241 PPELIArRDRIEALCEQHGVSLAAAALQFALAPPAVASVAPGASSPERVEENVALLATEIPAA 303
|
|
| AKR_AKR3F2 |
cd19139 |
Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB) and similar proteins; ... |
33-311 |
2.85e-31 |
|
Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB) and similar proteins; Escherichia coli DkgB/YafB (EC 1.1.1.346), also called 2,5-didehydrogluconate reductase (2-dehydro-L-gulonate-forming), or 2,5-DKG reductase B, or 2,5-DKGR B, or 25DKGR-B, is a founding member of aldo-keto reductase family 3 member F2 (AKR3F2). It catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG).
Pssm-ID: 381365 [Multi-domain] Cd Length: 248 Bit Score: 117.84 E-value: 2.85e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 33 WVLNEDDSRIVIKEALDLGINFFDTANVYSlgtSEEYLGRALKDYA-NRDEVVIATKVHGqmhkgpngSGLSRKAIMSEI 111
Cdd:cd19139 9 FRLKDDVVIDSVRTALELGYRHIDTAQIYD---NEAAVGQAIAESGvPRDELFITTKIWI--------DNLSKDKLLPSL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 112 DKSLKRLETDYVDLYIIHrW---DYDTPIEETMEALHDVVKAGKARYIGASAMYAWQFQKALHVAeknGWTKFVSMQNHL 188
Cdd:cd19139 78 EESLEKLRTDYVDLTLIH-WpspNDEVPVEEYIGALAEAKEQGLTRHIGVSNFTIALLDEAIAVV---GAGAIATNQIEL 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 189 NLIYRegEREMLPLCKEEKIGVTPYSPLASGRLTRDwsvtthrsetdqiqkskydatadsdrlvvERVASIAEKHGIPRT 268
Cdd:cd19139 154 SPYLQ--NRKLVAHCKQHGIHVTSYMTLAYGKVLDD-----------------------------PVLAAIAERHGATPA 202
|
250 260 270 280
....*....|....*....|....*....|....*....|...
gi 1267806617 269 HIALAWLLQKEPVTAPiiGATKTSHLENAVDALSIKLTPEEIA 311
Cdd:cd19139 203 QIALAWAMARGYAVIP--SSTKREHLRSNLLALDLTLDADDMA 243
|
|
| AKR_Fe-S_oxidoreductase |
cd19096 |
Fe-S oxidoreductase and similar proteins; The family includes a group of uncharacterized Fe-S ... |
14-302 |
2.16e-29 |
|
Fe-S oxidoreductase and similar proteins; The family includes a group of uncharacterized Fe-S oxidoreductase that belongs to aldo-keto reductase (AKR) superfamily. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381322 [Multi-domain] Cd Length: 255 Bit Score: 113.04 E-value: 2.16e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 14 SRLCLGCMGFgdANKWLHQwvLNEDDSRIVIKEALDLGINFFDTANVYSLGTSEEYLGRALKDYaNRDEVVIATKVhgqm 93
Cdd:cd19096 1 SVLGFGTMRL--PESDDDS--IDEEKAIEMIRYAIDAGINYFDTAYGYGGGKSEEILGEALKEG-PREKFYLATKL---- 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 94 hkgPNGSGLSRKAIMSEIDKSLKRLETDYVDLYIIH-----RWDYDTPIEETMEALHDVVKAGKARYIGASA-MYAWQFQ 167
Cdd:cd19096 72 ---PPWSVKSAEDFRRILEESLKRLGVDYIDFYLLHglnspEWLEKARKGGLLEFLEKAKKEGLIRHIGFSFhDSPELLK 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 168 KALhvaEKNGWTkFVSMQ-NHLNLIYREGeREMLPLCKEEKIGVTPYSPLASGRLTRDwsvtthrsetdqiQKSKYDATA 246
Cdd:cd19096 149 EIL---DSYDFD-FVQLQyNYLDQENQAG-RPGIEYAAKKGMGVIIMEPLKGGGLANN-------------PPEALAILC 210
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*.
gi 1267806617 247 DSDRLVVErvasiaekhgiprthIALAWLLQKEPVTAPIIGATKTSHLENAVDALS 302
Cdd:cd19096 211 GAPLSPAE---------------WALRFLLSHPEVTTVLSGMSTPEQLDENIAAAD 251
|
|
| PLN02587 |
PLN02587 |
L-galactose dehydrogenase |
3-222 |
3.32e-28 |
|
L-galactose dehydrogenase
Pssm-ID: 178198 [Multi-domain] Cd Length: 314 Bit Score: 111.02 E-value: 3.32e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 3 YVKLGNTGLDVSrlclgCMGFGDANKWLHQWVLNEDDSRIVIKEALDLGINFFDTANVYSLGTSEEYLGRALKDYA-NRD 81
Cdd:PLN02587 1 LRELGSTGLKVS-----SVGFGASPLGSVFGPVSEEDAIASVREAFRLGINFFDTSPYYGGTLSEKVLGKALKALGiPRE 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 82 EVVIATKVhgqmhkGPNGSG--LSRKAIMSEIDKSLKRLETDYVDLYIIHRWDY---DTPIEETMEALHDVVKAGKARYI 156
Cdd:PLN02587 76 KYVVSTKC------GRYGEGfdFSAERVTKSVDESLARLQLDYVDILHCHDIEFgslDQIVNETIPALQKLKESGKVRFI 149
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1267806617 157 GASAMYAWQFQKALHVAEKNGWTKFVSMQNH-LNLIYREgerEMLPLCKEEKIGVTPYSPLASGRLT 222
Cdd:PLN02587 150 GITGLPLAIFTYVLDRVPPGTVDVILSYCHYsLNDSSLE---DLLPYLKSKGVGVISASPLAMGLLT 213
|
|
| AKR_AKR15A1 |
cd19161 |
Microbacterium luteolum pyridoxal 4-dehydrogenase (PLD) and similar proteins; Microbacterium ... |
14-309 |
8.76e-28 |
|
Microbacterium luteolum pyridoxal 4-dehydrogenase (PLD) and similar proteins; Microbacterium luteolum PLD (EC1.1.1.107) is a founding member of aldo-keto reductase family 15 member A1 (AKR15A1). It catalyzes irreversible oxidation of pyridoxal.
Pssm-ID: 381387 [Multi-domain] Cd Length: 310 Bit Score: 110.11 E-value: 8.76e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 14 SRLCLGCMGFGDANKwlhqwVLNEDDSRIVIKEALDLGINFFDTANVYSLGTSEEYLGRALKDYaNRDEVVIATKVhGQM 93
Cdd:cd19161 1 SELGLGTAGLGNLYT-----AVSNADADATLDAAWDSGIRYFDTAPMYGHGLAEHRLGDFLREK-PRDEFVLSTKV-GRL 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 94 HKGPNGSGL------------------SRKAIMSEIDKSLKRLETDYVDLYIIH-------------RWDYDTpIEETME 142
Cdd:cd19161 74 LKPAREGSVpdpngfvdplpfeivydySYDGIMRSFEDSLQRLGLNRIDILYVHdigvythgdrkerHHFAQL-MSGGFK 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 143 ALHDVVKAGkarYIGASAMYAWQFQKALHVAEKNGWTKFVsMQNHLNLIYREGEREMLPLCKEEKIGVTPYSPLASGRLT 222
Cdd:cd19161 153 ALEELKKAG---VIKAFGLGVNEVQICLEALDEADLDCFL-LAGRYSLLDQSAEEEFLPRCEQRGTSLVIGGVFNSGILA 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 223 rdwsvtthrseTDQIQKSKYDATaDSDRLVVERVASI---AEKHGIPRTHIALAWLLQKEPVTAPIIGATKTSHLENAVD 299
Cdd:cd19161 229 -----------TGTKSGAKFNYG-DAPAEIISRVMEIekiCDAYNVPLAAAALQFPLRHPAVASVLTGARNPAQLRQNVE 296
|
330
....*....|
gi 1267806617 300 ALSIKLtPEE 309
Cdd:cd19161 297 AFQTDI-PEE 305
|
|
| AKR_unchar |
cd19099 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
11-299 |
3.35e-27 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381325 [Multi-domain] Cd Length: 316 Bit Score: 108.56 E-value: 3.35e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 11 LDVSRLCLGC--MGFGDANKWLHqwvlneddsRIVIKEALDLGINFFDTANVYSLGTSEEYLGRALKDYAN-----RDEV 83
Cdd:cd19099 1 LTLSSLGLGTyrGDSDDETDEEY---------REALKAALDSGINVIDTAINYRGGRSERLIGKALRELIEkggikRDEV 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 84 VIATK---VHG----------QMHKGPNGSGLSRKAI------MS------EIDKSLKRLETDYVDLYIIH--------- 129
Cdd:cd19099 72 VIVTKagyIPGdgdeplrplkYLEEKLGRGLIDVADSaglrhcISpayledQIERSLKRLGLDTIDLYLLHnpeeqllel 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 130 -RWDYDTPIEETMEALHDVVKAGKARYIGASamyAWQFQKA-------LHVAEKNGWTKFVSMQNH--------LNLIYR 193
Cdd:cd19099 152 gEEEFYDRLEEAFEALEEAVAEGKIRYYGIS---TWDGFRAppalpghLSLEKLVAAAEEVGGDNHhfkviqlpLNLLEP 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 194 EGEREM----------LPLCKEEKIGVTPYSPLASGRLTRdwsvtthrsetdqiqkskydatadsdrlVVERVASIAEKH 263
Cdd:cd19099 229 EALTEKntvkgealslLEAAKELGLGVIASRPLNQGQLLG----------------------------ELRLADLLALPG 280
|
330 340 350
....*....|....*....|....*....|....*.
gi 1267806617 264 GIPRTHIALAWLLQKEPVTAPIIGATKTSHLENAVD 299
Cdd:cd19099 281 GATLAQRALQFARSTPGVDSALVGMRRPEHVDENLA 316
|
|
| AKR_unchar |
cd19097 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
14-304 |
5.92e-27 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381323 [Multi-domain] Cd Length: 267 Bit Score: 106.84 E-value: 5.92e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 14 SRLCLGC----MGFGDANKwlhQWVLNEDDSRIVIKEALDLGINFFDTANVYslGTSEEYLGRALKdyaNRDEVVIATKV 89
Cdd:cd19097 1 SKLALGTaqfgLDYGIANK---SGKPSEKEAKKILEYALKAGINTLDTAPAY--GDSEKVLGKFLK---RLDKFKIITKL 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 90 HgqmhKGPNGSGLSRKAIMSEIDKSLKRLETDYVDLYIIHRW-DYDTPIEETMEALHDVVKAGKARYIGASAmYAWqfQK 168
Cdd:cd19097 73 P----PLKEDKKEDEAAIEASVEASLKRLKVDSLDGLLLHNPdDLLKHGGKLVEALLELKKEGLIRKIGVSV-YSP--EE 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 169 ALHVAEKNgwtKFVSMQNHLNLI-YREGEREMLPLCKEEKIGVtpysplasgrltrdwsvttH-RS---------ETDQI 237
Cdd:cd19097 146 LEKALESF---KIDIIQLPFNILdQRFLKSGLLAKLKKKGIEI-------------------HaRSvflqglllmEPDKL 203
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1267806617 238 QKSKYDAtadsdRLVVERVASIAEKHGIPRTHIALAWLLQKEPVTAPIIGATKTSHLENAVDALSIK 304
Cdd:cd19097 204 PAKFAPA-----KPLLKKLHELAKKLGLSPLELALGFVLSLPEIDKIVVGVDSLEQLKEIIAAFKKP 265
|
|
| AKR_AKR2E1-5 |
cd19116 |
AKR2E family of aldo-keto reductase (AKR); Bombyx mori 3-dehydroecdysone reductase is a ... |
33-314 |
2.94e-26 |
|
AKR2E family of aldo-keto reductase (AKR); Bombyx mori 3-dehydroecdysone reductase is a founding member of aldo-keto reductase family 2 member E4 (AKR2E4). It is a NADP-dependent oxidoreductase with high 3-dehydroecdysone reductase activity. It may play a role in the regulation of molting and has lower activity with phenylglyoxal and isatin (in vitro). This family also includes 3-dehydroecdysone 3b-reductase from Spodoptera littoralis and Trichoplusia ni, DL-glyceraldehyde reductase from Drosophila melanogaster, aldo-keto reductase from Bombyx mori, which correspond to aldo-keto reductase family 2 member E1, E2, E3 and E5 (AKR2E1/2/3/5), respectively.
Pssm-ID: 381342 [Multi-domain] Cd Length: 292 Bit Score: 105.44 E-value: 2.94e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 33 WVLNEDDS-RIVIKEALDLGINFFDTANVYSlgtSEEYLGRALKDYAN-----RDEVVIATKVHGQMHkgpngsglSRKA 106
Cdd:cd19116 19 WKLKDDEGvRQAVKHAIEAGYRHIDTAYLYG---NEAEVGEAIREKIAegvvkREDLFITTKLWNSYH--------EREQ 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 107 IMSEIDKSLKRLETDYVDLYIIH-------RWDYDTPIE---------ETMEALHDVVKAGKARYIGASAMYAWQFQKAL 170
Cdd:cd19116 88 VEPALRESLKRLGLDYVDLYLIHwpvafkeNNDSESNGDgslsdidylETWRGMEDLVKLGLTRSIGVSNFNSEQINRLL 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 171 hvaeKNGWTKFVSMQ--NHLNLIyregEREMLPLCKEEKIGVTPYSPLasGRLTRDwsvtthrsetdqiqkskyDATADS 248
Cdd:cd19116 168 ----SNCNIKPAVNQieVHPTLT----QEKLVAYCQSNGIVVMAYSPF--GRLVPR------------------GQTNPP 219
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1267806617 249 DRLVVERVASIAEKHGIPRTHIALAWLLQKEPVtaPIIGATKTSHLENAVDALSIKLTPEEIAFLE 314
Cdd:cd19116 220 PRLDDPTLVAIAKKYGKTTAQIVLRYLIDRGVV--PIPKSSNKKRIKENIDIFDFQLTPEEVAALN 283
|
|
| AKR_AKR1G1_CeAKR |
cd19154 |
Caenorhabditis elegans aldo-keto reductase (CeAKR) and similar proteins; CeAKR is a founding ... |
33-314 |
1.03e-24 |
|
Caenorhabditis elegans aldo-keto reductase (CeAKR) and similar proteins; CeAKR is a founding member of aldo-keto reductase family 1 member G1 (AKR1G1). It may catalyze the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.
Pssm-ID: 381380 [Multi-domain] Cd Length: 303 Bit Score: 101.33 E-value: 1.03e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 33 WVLNEDDSRIVIKEALDLGINFFDTANVYSlgtSEEYLGRALKDYAN-----RDEVVIATKVHGQMHKgpngsglsRKAI 107
Cdd:cd19154 20 WQSKGAEGITAVRTALKAGYRLIDTAFLYQ---NEEAIGEALAELLEegvvkREDLFITTKLWTHEHA--------PEDV 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 108 MSEIDKSLKRLETDYVDLYIIHR-W------------------DYDTPIEETMEALHDVVKAGKARYIGASAMYAWQFQK 168
Cdd:cd19154 89 EEALRESLKKLQLEYVDLYLIHApAafkddegesgtmengmsiHDAVDVEDVWRGMEKVYDEGLTKAIGVSNFNNDQIQR 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 169 ALHVAEkngwTKFVSMQNHLNLIYRegEREMLPLCKEEKIGVTPYSPLAS-GRLTRDWSVTTHRSET---DQIqkskyda 244
Cdd:cd19154 169 ILDNAR----VKPHNNQVECHLYFP--QKELVEFCKKHNISVTSYATLGSpGRANFTKSTGVSPAPNllqDPI------- 235
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 245 tadsdrlvverVASIAEKHGIPRTHIALAWLLQKEPVTAPiiGATKTSHLENAVDALSIKLTPEEIAFLE 314
Cdd:cd19154 236 -----------VKAIAEKHGKTPAQVLLRYLLQRGIAVIP--KSATPSRIKENFNIFDFSLSEEDMATLE 292
|
|
| AKR_AKR1G1_1I |
cd19111 |
Caenorhabditis elegans aldo-keto reductase (CeAKR), Coptotermes gestroi aldo-keto reductase ... |
30-315 |
3.52e-24 |
|
Caenorhabditis elegans aldo-keto reductase (CeAKR), Coptotermes gestroi aldo-keto reductase (CgAKR-1) and similar proteins; CeAKR is a founding member of aldo-keto reductase family 1 member G1 (AKR1G1). It may catalyze the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor. Coptotermes gestroi aldo-keto reductase (CgAKR-1) is a founding member of aldo-keto reductase family 1 member I (AKR1I). It is a multipurpose enzyme with potential biotechnological applications.
Pssm-ID: 381337 [Multi-domain] Cd Length: 286 Bit Score: 99.49 E-value: 3.52e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 30 LHQWVLNEDDSRIVIKEALDLGINFFDTANVYSlgtSEEYLGRALKDYAN-----RDEVVIATKVHGQmhkgpngsGLSR 104
Cdd:cd19111 9 LGTYQSPPEEVRAAVDYALFVGYRHIDTALSYQ---NEKAIGEALKWWLKngklkREEVFITTKLPPV--------YLEF 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 105 KAIMSEIDKSLKRLETDYVDLYIIH-------------RWDYDTPIEETMEALHDVVKAGKARYIGASAMYAWQFQKALh 171
Cdd:cd19111 78 KDTEKSLEKSLENLKLPYVDLYLIHhpcgfvnkkdkgeRELASSDVTSVWRAMEALVSEGKVKSIGLSNFNPRQINKIL- 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 172 vaeKNGWTKFVSMQNHLNLIYRegEREMLPLCKEEKIGVTPYSPLAS-GRLtrdwsvtthrsetdqiqkSKYDATADSDR 250
Cdd:cd19111 157 ---AYAKVKPSNLQLECHAYLQ--QRELRKFCNKKNIVVTAYAPLGSpGRA------------------NQSLWPDQPDL 213
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1267806617 251 LVVERVASIAEKHGIPRTHIALAWLLQKEpvTAPIIGATKTSHLENAVDALSIKLTPEEIAFLED 315
Cdd:cd19111 214 LEDPTVLAIAKELDKTPAQVLLRFVLQRG--TGVLPKSTNKERIEENFEVFDFELTEEHFKKLKT 276
|
|
| AKR_DrGR-like |
cd19136 |
Danio rerio glyoxal reductase-like (GR-like) protein and similar proteins; Danio rerio GR-like ... |
36-313 |
1.77e-23 |
|
Danio rerio glyoxal reductase-like (GR-like) protein and similar proteins; Danio rerio GR-like protein is the prototype of this family. It is an uncharacterized aldo/keto reductase family oxidoreductase similar to Bacillus subtilis glyoxal reductase (YvgN) that reduces glyoxal and methylglyoxal (2-oxopropanal).
Pssm-ID: 381362 [Multi-domain] Cd Length: 262 Bit Score: 97.32 E-value: 1.77e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 36 NEDDSRIVIKEALDLGINFFDTANVYSlgtSEEYLGRALKD-----YANRDEVVIATKVhgqmhkGPN--GSGLSRKAIM 108
Cdd:cd19136 13 GEEEVRQAVDAALKAGYRLIDTASVYR---NEADIGKALRDllpkyGLSREDIFITSKL------APKdqGYEKARAACL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 109 seidKSLKRLETDYVDLYIIH-----RWDYDTPIE-----ETMEALHDVVKAGKARYIGASamyawQFQKAlHVAEKNGW 178
Cdd:cd19136 84 ----GSLERLGTDYLDLYLIHwpgvqGLKPSDPRNaelrrESWRALEDLYKEGKLRAIGVS-----NYTVR-HLEELLKY 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 179 TKFVSMQNHLNLIYREGEREMLPLCKEEKIGVTPYSPLASGRLtrdwSVTTHrsetdqiqkskydatadsdrlvvERVAS 258
Cdd:cd19136 154 CEVPPAVNQVEFHPHLVQKELLKFCKDHGIHLQAYSSLGSGDL----RLLED-----------------------PTVLA 206
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*
gi 1267806617 259 IAEKHGIPRTHIALAWLLQKEPVTAPiiGATKTSHLENAVDALSIKLTPEEIAFL 313
Cdd:cd19136 207 IAKKYGRTPAQVLLRWALQQGIGVIP--KSTNPERIAENIKVFDFELSEEDMAEL 259
|
|
| dkgB |
PRK11172 |
2,5-didehydrogluconate reductase DkgB; |
44-314 |
4.57e-23 |
|
2,5-didehydrogluconate reductase DkgB;
Pssm-ID: 183012 [Multi-domain] Cd Length: 267 Bit Score: 96.25 E-value: 4.57e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 44 IKEALDLGINFFDTANVYSlgtSEEYLGRALKDYA-NRDEVVIATKVHGqmhkgpngSGLSRKAIMSEIDKSLKRLETDY 122
Cdd:PRK11172 22 VKTALELGYRAIDTAQIYD---NEAAVGQAIAESGvPRDELFITTKIWI--------DNLAKDKLIPSLKESLQKLRTDY 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 123 VDLYIIHrW---DYDTPIEETMEALHDVVKAGKARYIGASAMYAWQFQKALH-VAEKNGWTKFVSMQNHLNliyregERE 198
Cdd:PRK11172 91 VDLTLIH-WpspNDEVSVEEFMQALLEAKKQGLTREIGISNFTIALMKQAIAaVGAENIATNQIELSPYLQ------NRK 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 199 MLPLCKEEKIGVTPYSPLASGRLTRDwsvtthrsetdqiqkskydatadsdrlvvERVASIAEKHGIPRTHIALAWLLQK 278
Cdd:PRK11172 164 VVAFAKEHGIHVTSYMTLAYGKVLKD-----------------------------PVIARIAAKHNATPAQVILAWAMQL 214
|
250 260 270
....*....|....*....|....*....|....*....
gi 1267806617 279 EpvTAPIIGATKTSHLENAVDALSIKLTPEE---IAFLE 314
Cdd:PRK11172 215 G--YSVIPSSTKRENLASNLLAQDLQLDAEDmaaIAALD 251
|
|
| AKR_AKR5G1-3 |
cd19157 |
AKR5G family of aldo-keto reductase (AKR); Bacillus subtilis glyoxal reductase (GR), ... |
37-311 |
6.94e-23 |
|
AKR5G family of aldo-keto reductase (AKR); Bacillus subtilis glyoxal reductase (GR), uncharacterized oxidoreductase YtbE, and Bacillus aryabhattai aldo-keto reductase are founding members of aldo-keto reductase family 5 member G1-3 (AKR5G1-3), respectively. GR (YvgN, EC 1.1.1.283), also called methylglyoxal reductase, reduces glyoxal and methylglyoxal (2-oxopropanal). It is not involved in vitamin B6 biosynthesis.
Pssm-ID: 381383 [Multi-domain] Cd Length: 265 Bit Score: 95.54 E-value: 6.94e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 37 EDDSRIV--IKEALDLGINFFDTANVYSlgtSEEYLGRALKDY-ANRDEVVIATKVHGqmhkgpngSGLSRKAIMSEIDK 113
Cdd:cd19157 21 EEGSEVVnaVKTALKNGYRSIDTAAIYG---NEEGVGKGIKESgIPREELFITSKVWN--------ADQGYDSTLKAFEA 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 114 SLKRLETDYVDLYIIHrWDYDTPIEETMEALHDVVKAGKARYIGASAMYAWQFQKALHVAEkngwtkFVSMQNHLNLIYR 193
Cdd:cd19157 90 SLERLGLDYLDLYLIH-WPVKGKYKETWKALEKLYKDGRVRAIGVSNFQVHHLEDLLADAE------IVPMVNQVEFHPR 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 194 EGEREMLPLCKEEKIGVTPYSPLASGRLtrdwsvtthrsetdqiqkskydatadsdrLVVERVASIAEKHGIPRTHIALA 273
Cdd:cd19157 163 LTQKELRDYCKKQGIQLEAWSPLMQGQL-----------------------------LDNPVLKEIAEKYNKSVAQVILR 213
|
250 260 270 280
....*....|....*....|....*....|....*....|..
gi 1267806617 274 WLLQKEPVTAPiigatKTSH----LENAvDALSIKLTPEEIA 311
Cdd:cd19157 214 WDLQNGVVTIP-----KSIKehriIENA-DVFDFELSQEDMD 249
|
|
| AKR_AKR5A_5G |
cd19126 |
AKR5A and AKR5G families of aldo-keto reductase (AKR); The AKR5A family of AKR includes ... |
36-315 |
1.10e-22 |
|
AKR5A and AKR5G families of aldo-keto reductase (AKR); The AKR5A family of AKR includes prostaglandin F2-alpha synthase (PGFS) from Leishmania major (AKR5A1) and Trypanosoma brucei (AKR5A2). PGFS, also called 9,11-endoperoxide prostaglandin H2 reductase, catalyzes the NADP-dependent formation of prostaglandin F2-alpha from prostaglandin H2. It has also aldo/ketoreductase activity for synthetic substrates 9,10-phenanthrenequinone and p-nitrobenzaldehyde. The AKR5G family of AKR includes Bacillus subtilis glyoxal reductase (GR), uncharacterized oxidoreductase YtbE, and Bacillus aryabhattai aldo-keto reductase, which corresponds to aldo-keto reductase family 5 member G1-3 (AKR5G1-3), respectively. GR (YvgN, EC 1.1.1.283), also called methylglyoxal reductase, reduces glyoxal and methylglyoxal (2-oxopropanal). It is not involved in vitamin B6 biosynthesis.
Pssm-ID: 381352 [Multi-domain] Cd Length: 254 Bit Score: 94.81 E-value: 1.10e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 36 NEDDSRIVIKEALDLGINFFDTANVYSlgtSEEYLGRALKDYA-NRDEVVIATKVHGQMHKGPNGSglsrkaimSEIDKS 114
Cdd:cd19126 21 DGDETERAVQTALENGYRSIDTAAIYK---NEEGVGEAIRESGvPREELFVTTKLWNDDQRARRTE--------DAFQES 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 115 LKRLETDYVDLYIIHrWDYDTPIEETMEALHDVVKAGKARYIGASamyawQFQKAlHVAEKNGWTKFVSMQNHLNLIYRE 194
Cdd:cd19126 90 LDRLGLDYVDLYLIH-WPGKDKFIDTWKALEKLYASGKVKAIGVS-----NFQEH-HLEELLAHADVVPAVNQVEFHPYL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 195 GEREMLPLCKEEKIGVTPYSPLASGRLTRDwsvtthrsetdqiqkskydatadsdrlvvERVASIAEKHGIPRTHIALAW 274
Cdd:cd19126 163 TQKELRGYCKSKGIVVEAWSPLGQGGLLSN-----------------------------PVLAAIGEKYGKSAAQVVLRW 213
|
250 260 270 280
....*....|....*....|....*....|....*....|.
gi 1267806617 275 LLQKEPVTAPiiGATKTSHLENAVDALSIKLTPEEIAFLED 315
Cdd:cd19126 214 DIQHGVVTIP--KSVHASRIKENADIFDFELSEDDMTAIDA 252
|
|
| AKR_galDH-like |
cd19153 |
L-galactose dehydrogenase (L-galDH), D-arabinose 1-dehydrogenase (ARA2) and similar proteins; ... |
5-265 |
2.02e-22 |
|
L-galactose dehydrogenase (L-galDH), D-arabinose 1-dehydrogenase (ARA2) and similar proteins; L-galDH (EC 1.1.1.316), also called L-galactose 1-dehydrogenase, catalyzes the oxidation of L-galactose to L-galactono-1,4-lactone in the presence of NAD(+). It uses NAD(+) as a hydrogen acceptor much more efficiently than NADP(+). ARA2 (EC1.1.1.116), also called NAD(+)-specific D-arabinose dehydrogenase, catalyzes the the oxidation of D-arabinose to D-arabinono-1,4-lactone in the presence of NAD(+).
Pssm-ID: 381379 [Multi-domain] Cd Length: 294 Bit Score: 94.91 E-value: 2.02e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 5 KLGNTGLDVSRLCLGCMGFGDankwLHQWVLNEDDSRIVIKEALDLGINFFDTANVYSLGTSEEYLGRALKDYAN-RDEV 83
Cdd:cd19153 4 TLEIALGNVSPVGLGTAALGG----VYGDGLEQDEAVAIVAEAFAAGINHFDTSPYYGAESSEAVLGKALAALQVpRSSY 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 84 VIATKVhGQMHKGpnGSGLSRKAIMSEIDKSLKRLETDYVDLYIIHR---WDYDTPIEETMEALHDVVKAGKARYIGASA 160
Cdd:cd19153 80 TVATKV-GRYRDS--EFDYSAERVRASVATSLERLHTTYLDVVYLHDiefVDYDTLVDEALPALRTLKDEGVIKRIGIAG 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 161 ----MYAWQFQKAlhvaeKNGWTKFVSMQNHLNLIYREGEREMLPLCKEEKIGVTPYSPLASGRLT----RDWSVTTHRS 232
Cdd:cd19153 157 ypldTLTRATRRC-----SPGSLDAVLSYCHLTLQDARLESDAPGLVRGAGPHVINASPLSMGLLTsqgpPPWHPASGEL 231
|
250 260 270
....*....|....*....|....*....|....*.
gi 1267806617 233 ETDQIQKSKYDATADSDrlvVERVA---SIAEKHGI 265
Cdd:cd19153 232 RHYAAAADAVCASVEAS---LPDLAlqySLAAHAGV 264
|
|
| AKR_AKR5C2 |
cd19131 |
Escherichia coli 2,5-diketo-D-gluconic acid reductase A (DkgA/YqhE) and similar proteins; ... |
33-284 |
5.88e-22 |
|
Escherichia coli 2,5-diketo-D-gluconic acid reductase A (DkgA/YqhE) and similar proteins; Escherichia coli DkgA/YqhE is a founding member of aldo-keto reductase family 5 member C2 (AKR5C2). DkgA/YqhE (EC 1.1.1.274), also called 2,5-DKG reductase A, or 2,5-DKGR A, or 25DKGR-A, or AKR5C, catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG). It is also capable of stereoselective -keto ester reductions on ethyl acetoacetate and other 2-substituted derivatives.
Pssm-ID: 381357 [Multi-domain] Cd Length: 256 Bit Score: 92.82 E-value: 5.88e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 33 WVLNEDDSRIVIKEALDLGINFFDTANVYSlgtSEEYLGRALKDYA-NRDEVVIATKVHGQMHkgpnGSGLSRKAImsei 111
Cdd:cd19131 18 WQVSNDEAASAVREALEVGYRSIDTAAIYG---NEEGVGKAIRASGvPREELFITTKLWNSDQ----GYDSTLRAF---- 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 112 DKSLKRLETDYVDLYIIHrWdyDTPIE----ETMEALHDVVKAGKARYIGASamyawQFQKAlHVAEKNGWTKFVSMQNH 187
Cdd:cd19131 87 DESLRKLGLDYVDLYLIH-W--PVPAQdkyvETWKALIELKKEGRVKSIGVS-----NFTIE-HLQRLIDETGVVPVVNQ 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 188 LNLIYREGEREMLPLCKEEKIGVTPYSPLASGRLTRDwsvtthrsetdqiqkskydatadsdrlvvERVASIAEKHGIPR 267
Cdd:cd19131 158 IELHPRFQQRELRAFHAKHGIQTESWSPLGQGGLLSD-----------------------------PVIGEIAEKHGKTP 208
|
250
....*....|....*..
gi 1267806617 268 THIALAWLLQKEPVTAP 284
Cdd:cd19131 209 AQVVIRWHLQNGLVVIP 225
|
|
| AKR_AKR5F1 |
cd19133 |
the AKR5F family of aldo-keto reductase (AKR); Klebsiella sp. 2,5-diketo-D-gluconic acid ... |
44-311 |
1.95e-21 |
|
the AKR5F family of aldo-keto reductase (AKR); Klebsiella sp. 2,5-diketo-D-gluconic acid reductase (2,5-DKG reductase) is a founding member of aldo-keto reductase family 5 member F1 (AKR5F1). It catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG).
Pssm-ID: 381359 [Multi-domain] Cd Length: 255 Bit Score: 91.48 E-value: 1.95e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 44 IKEALDLGINFFDTANVYSlgtSEEYLGRALKDYA-NRDEVVIATKVhgqmhkgpNGSGLSRKAIMSEIDKSLKRLETDY 122
Cdd:cd19133 29 VLEAIKAGYRLIDTAAAYG---NEEAVGRAIKKSGiPREELFITTKL--------WIQDAGYEKAKKAFERSLKRLGLDY 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 123 VDLYIIHRWDYDtpIEETMEALHDVVKAGKARYIGASAMYAWQFQKALHVAEkngwTKFVSMQNHLNLIY-REGEREMLp 201
Cdd:cd19133 98 LDLYLIHQPFGD--VYGAWRAMEELYKEGKIRAIGVSNFYPDRLVDLILHNE----VKPAVNQIETHPFNqQIEAVEFL- 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 202 lcKEEKIGVTPYSPLASGRltrdwsvtthrsetdqiqkskydatadSDRLVVERVASIAEKHGIPRTHIALAWLLQKEPV 281
Cdd:cd19133 171 --KKYGVQIEAWGPFAEGR---------------------------NNLFENPVLTEIAEKYGKSVAQVILRWLIQRGIV 221
|
250 260 270
....*....|....*....|....*....|...
gi 1267806617 282 TAPiigatKTSHLENAVDALSI---KLTPEEIA 311
Cdd:cd19133 222 VIP-----KSVRPERIAENFDIfdfELSDEDME 249
|
|
| AKR_AKR5A1_2 |
cd19156 |
AKR5A family of aldo-keto reductase (AKR); Prostaglandin F2-alpha synthase (PGFS) from ... |
44-311 |
5.09e-21 |
|
AKR5A family of aldo-keto reductase (AKR); Prostaglandin F2-alpha synthase (PGFS) from Leishmania major and Trypanosoma brucei are founding members of aldo-keto reductase family 5 member A1 (AKR5A1) and A2 (AKR5A2), respectively. PGFS, also called 9,11-endoperoxide prostaglandin H2 reductase, catalyzes the NADP-dependent formation of prostaglandin F2-alpha from prostaglandin H2. It has also aldo/ketoreductase activity toward the synthetic substrates 9,10-phenanthrenequinone and p-nitrobenzaldehyde.
Pssm-ID: 381382 [Multi-domain] Cd Length: 266 Bit Score: 90.65 E-value: 5.09e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 44 IKEALDLGINFFDTANVYSlgtSEEYLGRALKDYA-NRDEVVIATKVHGqmhkgpngSGLSRKAIMSEIDKSLKRLETDY 122
Cdd:cd19156 29 VKWAIEAGYRHIDTAAIYK---NEEGVGQGIRESGvPREEVFVTTKLWN--------SDQGYESTLAAFEESLEKLGLDY 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 123 VDLYIIHrWDYDTPIEETMEALHDVVKAGKARYIGASAMYAWQFQKALHVAekngwtKFVSMQNHLNLIYREGEREMLPL 202
Cdd:cd19156 98 VDLYLIH-WPVKGKFKDTWKAFEKLYKEKKVRAIGVSNFHEHHLEELLKSC------KVAPMVNQIELHPLLTQEPLRKF 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 203 CKEEKIGVTPYSPLASGRLTRDwsvtthrsetdqiqkskydatadsdrlvvERVASIAEKHGIPRTHIALAWLLQKEPVT 282
Cdd:cd19156 171 CKEKNIAVEAWSPLGQGKLLSN-----------------------------PVLKAIGKKYGKSAAQVIIRWDIQHGIIT 221
|
250 260 270
....*....|....*....|....*....|...
gi 1267806617 283 APiigatKTSH----LENAvDALSIKLTPEEIA 311
Cdd:cd19156 222 IP-----KSVHeeriQENF-DVFDFELTAEEIR 248
|
|
| AKR_GlAR-like |
cd19128 |
Giardia lamblia aldose reductase (AR) and similar proteins; Giardia lamblia AR (EC 1.1.1.21), ... |
20-313 |
1.02e-20 |
|
Giardia lamblia aldose reductase (AR) and similar proteins; Giardia lamblia AR (EC 1.1.1.21), also called aldehyde reductase, is the prototype of this family. It catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.
Pssm-ID: 381354 [Multi-domain] Cd Length: 277 Bit Score: 89.89 E-value: 1.02e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 20 CMGFGdankwlhQWVLNEDDSRIVIKEALDLGINFFDTANVYSlgtSEEYLGRALK-----DYANRDEVVIATKVHGQMH 94
Cdd:cd19128 3 RLGFG-------TYKITESESKEAVKNAIKAGYRHIDCAYYYG---NEAFIGIAFSeifkdGGVKREDLFITSKLWPTMH 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 95 KGPNgsglsrkaIMSEIDKSLKRLETDYVDLYIIH---RWDYDT----------------PIEETMEALHDVVKAGKARY 155
Cdd:cd19128 73 QPEN--------VKEQLLITLQDLQLEYLDLFLIHwplAFDMDTdgdprddnqiqslskkPLEDTWRAMEQCVDEKLTKN 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 156 IGASAMYAWQFQKALHvaekngwtkFVSMQNHLNLI----YREGEReMLPLCKEEKIGVTPYSPLasGRLTRDWSVTThr 231
Cdd:cd19128 145 IGVSNYSTKLLTDLLN---------YCKIKPFMNQIechpYFQNDK-LIKFCIENNIHVTAYRPL--GGSYGDGNLTF-- 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 232 SETDQIQkskydatadsdrlvvervaSIAEKHGIPRTHIALAWLLQKEPVTAPIIGATKT-SHLENAVDALSIKLTPEEI 310
Cdd:cd19128 211 LNDSELK-------------------ALATKYNTTPPQVIIAWHLQKWPKNYSVIPKSANkSRCQQNFDINDLALTKEDM 271
|
...
gi 1267806617 311 AFL 313
Cdd:cd19128 272 DAI 274
|
|
| AKR_AKR1I_CgAKR1 |
cd19155 |
Coptotermes gestroi aldo-keto reductase (CgAKR-1) and similar proteins; Coptotermes gestroi ... |
44-313 |
3.53e-20 |
|
Coptotermes gestroi aldo-keto reductase (CgAKR-1) and similar proteins; Coptotermes gestroi aldo-keto reductase (CgAKR-1) is a founding member of aldo-keto reductase family 1 member I (AKR1I). It is a multipurpose enzyme with potential biotechnological applications.
Pssm-ID: 381381 [Multi-domain] Cd Length: 307 Bit Score: 89.12 E-value: 3.53e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 44 IKEALDLGINFFDTANVYSlgtSEEYLGRALKDY-----ANRDEVVIATKVhgqmhkgPNGSGLSRKaIMSEIDKSLKRL 118
Cdd:cd19155 31 VDTALEAGYRHIDTAYVYR---NEAAIGNVLKKWidsgkVKREELFIVTKL-------PPGGNRREK-VEKFLLKSLEKL 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 119 ETDYVDLYIIH---------------------RWDYDTPIEETMEALHDVVKAGKARYIGASAMYAWQFQKALhvaeKNG 177
Cdd:cd19155 100 QLDYVDLYLIHfpvgslskeddsgkldptgehKQDYTTDLLDIWKAMEAQVDQGLTRSIGLSNFNREQMARIL----KNA 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 178 WTKFVSMQNHLNLIYRegEREMLPLCKEEKIGVTPYSPLASGRLTRdWSVTTHRSETDQiqkskydatadSDRLVVERVA 257
Cdd:cd19155 176 RIKPANLQVELHVYLQ--QKDLVDFCSTHSITVTAYAPLGSPGAAH-FSPGTGSPSGSS-----------PDLLQDPVVK 241
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*.
gi 1267806617 258 SIAEKHGIPRTHIALAWLLQKEPVTAPiiGATKTSHLENAVDALSIKLTPEEIAFL 313
Cdd:cd19155 242 AIAERHGKSPAQVLLRWLMQRGVVVIP--KSTNAARIKENFQVFDFELTEADMAKL 295
|
|
| AKR_AKR3G1 |
cd19123 |
AKR3G family of aldo-keto reductase (AKR); Synechocystis sp. aldo/keto reductase slr0942 is a ... |
44-315 |
1.18e-19 |
|
AKR3G family of aldo-keto reductase (AKR); Synechocystis sp. aldo/keto reductase slr0942 is a founding member of aldo-keto reductase family 3 member G1 (AKR3G1). It is an aldo/keto reductase that catalyzes the NADPH-dependent reduction of aldehyde- and ketone-groups of different classes of carbonyl compounds to the corresponding alcohols.
Pssm-ID: 381349 [Multi-domain] Cd Length: 297 Bit Score: 87.47 E-value: 1.18e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 44 IKEALDLGINFFDTANVYSlgtSEEYLGRALKDYAN-----RDEVVIATKVHGQMHKgpngsglsRKAIMSEIDKSLKRL 118
Cdd:cd19123 31 VKQALEAGYRHIDCAAIYG---NEAEIGAALAEVFKegkvkREDLWITSKLWNNSHA--------PEDVLPALEKTLADL 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 119 ETDYVDLYIIHrW---------------DY----DTPIEETMEALHDVVKAGKARYIGASAMYAWQFQK----ALHVAEK 175
Cdd:cd19123 100 QLDYLDLYLMH-WpvalkkgvgfpesgeDLlslsPIPLEDTWRAMEELVDKGLCRHIGVSNFSVKKLEDllatARIKPAV 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 176 NGwtkfVSMQNHLNliyregEREMLPLCKEEKIGVTPYSPLASGrltrdwsvtthrsetdqiQKSKYDATADSDRLVVER 255
Cdd:cd19123 179 NQ----VELHPYLQ------QPELLAFCRDNGIHLTAYSPLGSG------------------DRPAAMKAEGEPVLLEDP 230
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1267806617 256 V-ASIAEKHGIPRTHIALAWLLQKEPVTAPiiGATKTSHLENAVDALSIKLTPEEIAFLED 315
Cdd:cd19123 231 ViNKIAEKHGASPAQVLIAWAIQRGTVVIP--KSVNPERIQQNLEAAEVELDASDMATIAA 289
|
|
| AKR_AKR3A1-2 |
cd19117 |
AKR3A family of aldo-keto reductase (AKR); Saccharomyces cerevisiae Gcy1p and Ypr1p are ... |
30-284 |
2.43e-19 |
|
AKR3A family of aldo-keto reductase (AKR); Saccharomyces cerevisiae Gcy1p and Ypr1p are founding members of aldo-keto reductase family 3 member A1 (AKR3A1) and A2 (AKR3A2), respectively. Gcy1p, also called galactose-inducible crystallin-like protein 1, is a glycerol dehydrogenase involved in glycerol catabolism under microaerobic conditions. It has mRNA binding activity. Ypr1p acts as a 2-methylbutyraldehyde reductase that displays high specific activity towards 2-methylbutyraldehyde, as well as other aldehydes such as hexanal.
Pssm-ID: 381343 [Multi-domain] Cd Length: 284 Bit Score: 86.40 E-value: 2.43e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 30 LHQWVLNEDDSRIVIKEALDLGINFFDTANVYSlgtSEEYLGRALKDYA-NRDEVVIATKVHGQMHKGPNGSglsrkaim 108
Cdd:cd19117 19 LGTWQSKPNEVAKAVEAALKAGYRHIDTAAIYG---NEEEVGQGIKDSGvPREEIFITTKLWCTWHRRVEEA-------- 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 109 seIDKSLKRLETDYVDLYIIHrW------DYDTPI----------------EETMEALHDVVKAGKARYIGASAMYAWQF 166
Cdd:cd19117 88 --LDQSLKKLGLDYVDLYLMH-WpvpldpDGNDFLfkkddgtkdhepdwdfIKTWELMQKLPATGKVKAIGVSNFSIKNL 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 167 QKALhvaeKNGWTKFVSMQNHLNLIYREGEREMLPLCKEEKIGVTPYSPLASgrltrdwsvtthrsetdqiqkskydatA 246
Cdd:cd19117 165 EKLL----ASPSAKIVPAVNQIELHPLLPQPKLVDFCKSKGIHATAYSPLGS---------------------------T 213
|
250 260 270
....*....|....*....|....*....|....*...
gi 1267806617 247 DSDRLVVERVASIAEKHGIPRTHIALAWLLQKEPVTAP 284
Cdd:cd19117 214 NAPLLKEPVIIKIAKKHGKTPAQVIISWGLQRGYSVLP 251
|
|
| PRK10376 |
PRK10376 |
putative oxidoreductase; Provisional |
1-315 |
6.44e-19 |
|
putative oxidoreductase; Provisional
Pssm-ID: 236676 [Multi-domain] Cd Length: 290 Bit Score: 85.02 E-value: 6.44e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 1 MKYVKLGNT----GLDVSRlclgcMGFGdANKWLHQWVL----NEDDSRIVIKEALDLGINFFDTANVYSLGTSEEYLGR 72
Cdd:PRK10376 1 MSTIMSSGTftlgGRSVNR-----LGYG-AMQLAGPGVFgppkDRDAAIAVLREAVALGVNHIDTSDFYGPHVTNQLIRE 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 73 ALKDYanRDEVVIATKVHGQmhKGPNGS---GLSRKAIMSEIDKSLKRLETDYVDLYIIHRW-DYDTP----IEETMEAL 144
Cdd:PRK10376 75 ALHPY--PDDLTIVTKVGAR--RGEDGSwlpAFSPAELRRAVHDNLRNLGLDVLDVVNLRLMgDGHGPaegsIEEPLTVL 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 145 HDVVKAGKARYIGASAMYAWQfqkalhVAEKNGWTKFVSMQNHLNLIYReGEREMLPLCKEEKIGVTPYSPLasGRLTrd 224
Cdd:PRK10376 151 AELQRQGLVRHIGLSNVTPTQ------VAEARKIAEIVCVQNHYNLAHR-ADDALIDALARDGIAYVPFFPL--GGFT-- 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 225 wsvtthrsetdQIQKSKYDAtadsdrlvvervasIAEKHGIPRTHIALAWLLQKEPVTAPIIGATKTSHLENAVDALSIK 304
Cdd:PRK10376 220 -----------PLQSSTLSD--------------VAASLGATPMQVALAWLLQRSPNILLIPGTSSVAHLRENLAAAELV 274
|
330
....*....|.
gi 1267806617 305 LTPEEIAFLED 315
Cdd:PRK10376 275 LSEEVLAELDG 285
|
|
| AKR_AKR1A1-4 |
cd19106 |
AKR1A family of aldo-keto reductase (AKR); The AKR1A family of AKR includes alcohol ... |
44-314 |
4.39e-17 |
|
AKR1A family of aldo-keto reductase (AKR); The AKR1A family of AKR includes alcohol dehydrogenase [NADP(+)] (ALR, EC 1.1.1.2) from Homo sapiens (AKR1A1), Sus scrofa (AKR1A2), Rattus norvegicus (liver, AKR1A3), and Mus musculus (AKR1A4). ALR, also known as aldehyde reductase, or ALDR1, catalyzes the NADPH-dependent reduction of a variety of aromatic and aliphatic aldehydes to their corresponding alcohols. In vitro substrates include succinic semialdehyde, 4-nitrobenzaldehyde, 1,2-naphthoquinone, methylglyoxal, and D-glucuronic acid.
Pssm-ID: 381332 [Multi-domain] Cd Length: 305 Bit Score: 80.12 E-value: 4.39e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 44 IKEALDLGINFFDTANVYSlgtSEEYLGRALKD------YANRDEVVIATKVHGQMHKGPNGSGLSRKaimseidkSLKR 117
Cdd:cd19106 26 VKYALDAGYRHIDCAAVYG---NEQEVGEALKEkvgpgkAVPREDLFVTSKLWNTKHHPEDVEPALRK--------TLKD 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 118 LETDYVDLYIIHrWDY--------------------DTPIEETMEALHDVVKAGKARYIGASAMYAWQFQKALHVAEKNG 177
Cdd:cd19106 95 LQLDYLDLYLIH-WPYafergdnpfpknpdgtirydSTHYKETWKAMEKLVDKGLVKAIGLSNFNSRQIDDILSVARIKP 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 178 WTKFVSMQNHLNliyregEREMLPLCKEEKIGVTPYSPLASGrlTRDWsvtthrsetdqiqkskydATADSDRLVVE-RV 256
Cdd:cd19106 174 AVLQVECHPYLA------QNELIAHCKARGLVVTAYSPLGSP--DRPW------------------AKPDEPVLLEEpKV 227
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 1267806617 257 ASIAEKHGIPRTHIALAWLLQKEPVTAPiIGATKTSHLENaVDALSIKLTPEEIAFLE 314
Cdd:cd19106 228 KALAKKYNKSPAQILLRWQVQRGVVVIP-KSVTPSRIKQN-IQVFDFTLSPEEMKQLD 283
|
|
| AKR_ARA2 |
cd19164 |
D-arabinose 1-dehydrogenase (ARA2) and similar proteins; ARA2 (EC1.1.1.116), also called NAD(+) ... |
11-160 |
4.84e-16 |
|
D-arabinose 1-dehydrogenase (ARA2) and similar proteins; ARA2 (EC1.1.1.116), also called NAD(+)-specific D-arabinose dehydrogenase, catalyzes the the oxidation of D-arabinose to D-arabinono-1,4-lactone in the presence of NAD(+).
Pssm-ID: 381390 [Multi-domain] Cd Length: 298 Bit Score: 76.93 E-value: 4.84e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 11 LDVSRLCLGCMGFGdankwlHQWvlNEDDSRI----VIKEALDLGINFFDTANVYslGTSEEYLGRALKDYAN---RDEV 83
Cdd:cd19164 11 AGLPPLIFGAATFS------YQY--TTDPESIppvdIVRRALELGIRAFDTSPYY--GPSEIILGRALKALRDefpRDTY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 84 VIATKVhGqmHKGPNGSGLSRKAIMSEIDKSLKRLETDYVDLYIIHRWDYDTPiEETMEALHDVVK---AGKARYIGASA 160
Cdd:cd19164 81 FIITKV-G--RYGPDDFDYSPEWIRASVERSLRRLHTDYLDLVYLHDVEFVAD-EEVLEALKELFKlkdEGKIRNVGISG 156
|
|
| AKR_AKR3D1 |
cd19121 |
AKR3D family of aldo-keto reductase (AKR); Trichoderma reesei D-galacturonate reductase (GAR1, ... |
1-315 |
4.96e-16 |
|
AKR3D family of aldo-keto reductase (AKR); Trichoderma reesei D-galacturonate reductase (GAR1, EC 1.1.1.365), also called D-galacturonic acid reductase, or GalUR, is a founding member of aldo-keto reductase family 3 member D1 (AKR3D1). It mediates the reduction of D-galacturonate to L-galactonate, the first step in D-galacturonate catabolic process. It also has activity with D-glucuronate and DL-glyceraldehyde. Its activity is seen only with NADPH and not with NADH.
Pssm-ID: 381347 [Multi-domain] Cd Length: 279 Bit Score: 76.80 E-value: 4.96e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 1 MKYVKLgNTGLDVSRLCLGcmgfgdankwlhQWVLNEDDSRIVIKEALDLGINFFDTANVYSlgtSEEYLGRALKDYAN- 79
Cdd:cd19121 1 MTSFKL-NTGASIPAVGLG------------TWQAKAGEVKAAVAHALKIGYRHIDGALCYQ---NEDEVGEGIKEAIAg 64
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 80 ---RDEVVIATKVHGQMHKGPNGSglsrkaimseIDKSLKRLETDYVDLYIIHrW-----------------------DY 133
Cdd:cd19121 65 gvkREDLFVTTKLWSTYHRRVELC----------LDRSLKSLGLDYVDLYLVH-WpvllnpngnhdlfptlpdgsrdlDW 133
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 134 DTPIEETMEALHDVVKAGKARYIGASAMYAWQFQKALHVAekngwtKFVSMQNHLNLIYREGEREMLPLCKEEKIGVTPY 213
Cdd:cd19121 134 DWNHVDTWKQMEKVLKTGKTKAIGVSNYSIPYLEELLKHA------TVVPAVNQVENHPYLPQQELVDFCKEKGILIEAY 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 214 SPLASgrltrdwsvtthrsetdqiqkskydatADSDRLVVERVASIAEKHGIPRTHIALAWLLQKEPVTAPiigatKTSH 293
Cdd:cd19121 208 SPLGS---------------------------TGSPLISDEPVVEIAKKHNVGPGTVLISYQVARGAVVLP-----KSVT 255
|
330 340
....*....|....*....|...
gi 1267806617 294 LENAVDALS-IKLTPEEIAFLED 315
Cdd:cd19121 256 PDRIKSNLEiIDLDDEDMNKLND 278
|
|
| AKR_AKR4A_4B |
cd19124 |
AKR4A and AKR4B families of aldo-keto reductase (AKR); The AKR4A family of AKR includes ... |
38-309 |
9.36e-16 |
|
AKR4A and AKR4B families of aldo-keto reductase (AKR); The AKR4A family of AKR includes Glycine max NAD(P)H-dependent 6'-deoxychalcone synthase (6DCS, EC 3.1.170), chalcone reductase (CHR, EC 2.3.1.74) from Medicago sativa, Glycyrrhiza echinate, and Glycyrrhiza glabra, which are founding members of aldo-keto reductase family 4 member A1 (AKR4A1), A2 (AKR4A2), A3 (AKR4A3), and A4 (AKR4A4), respectively. NAD(P)H-6DCS co-acts with chalcone synthase in formation of 4,2',4'-trihydroxychalcone, involved in the biosynthesis of glyceollin type phytoalexins. CHR, also called chalcone polyketide reductase, is a key enzyme of the flavonoid/isoflavonoid biosynthesis pathway. The AKR4B family of AKR includes Sesbania rostrate chalcone reductase (CHR, AKR4B1), Papaver somniferum codeinone reductase (COR, AKR4B2/ AKR4B3), Fragaria x ananassa D-galacturonate reductase (GalUR, AKR4B4), deoxymugineic acid synthase 1 (DMAS1) from Zea mays (AKR4B5), Oryza sativa (AKR4B6), Hordeum vulgare (AKR4B7), Triticum aestivum (AKR4B8), and Erythroxylum coca methylecgonone reductase (MecgoR, AKR4B10). CHR, also called chalcone polyketide reductase, is a key enzyme of the flavonoid/isoflavonoid biosynthesis pathway. NADPH-dependent COR and non-functional NADPH-dependent COR from Papaver somniferum are founding members of aldo-keto reductase family 4 member B2 (AKR4B2) and B3 (AKR4B3), respectively. NADPH-dependent COR (EC 1.1.1.247) reduces codeinone to codeine in the penultimate step in morphine biosynthesis. It can use morphinone, hydrocodone, and hydromorphone as substrates during reductive reaction with NADPH as cofactor, and morphine and dihydrocodeine as substrates during oxidative reaction with NADP as cofactor. GalUR (EC 1.1.1.365), also called aldo-keto reductase 2 (AKR2), is involved in ascorbic acid (vitamin C) biosynthesis by catalyzing the conversion from L-galactonate and NADP(+) to D-galacturonate and NADPH. DMAS1 (EC 1.1.1.285) catalyzes the reduction of a 3''-keto intermediate during the biosynthesis of 2'-deoxymugineic acid (DMA) from L-Met. It is involved in the formation of phytosiderophores (MAs) belonging to the mugineic acid family and required to acquire iron. MecgoR catalyzes the stereospecific reduction of methylecgonone to methylecgonine, the penultimate step in cocaine biosynthesis.
Pssm-ID: 381350 [Multi-domain] Cd Length: 281 Bit Score: 76.15 E-value: 9.36e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 38 DDSRIVIKEALDLGINFFDTANVYSlgtSEEYLGRALKD------YANRDEVVIATKVHGqmhkgpngSGLSRKAIMSEI 111
Cdd:cd19124 20 EDIKAAVLEAIEVGYRHFDTAAAYG---TEEALGEALAEalrlglVKSRDELFVTSKLWC--------SDAHPDLVLPAL 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 112 DKSLKRLETDYVDLYIIHrW-------DYDTPIEE----------TMEALHDVVKAGKARYIGASAMYAWQFQKALHVAE 174
Cdd:cd19124 89 KKSLRNLQLEYVDLYLIH-WpvslkpgKFSFPIEEedflpfdikgVWEAMEECQRLGLTKAIGVSNFSCKKLQELLSFAT 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 175 ----KNgwtkfvsmQNHLNLIYRegEREMLPLCKEEKIGVTPYSPLASGRltrdwsvtthrsetdqiQKSKYDATADSDR 250
Cdd:cd19124 168 ippaVN--------QVEMNPAWQ--QKKLREFCKANGIHVTAYSPLGAPG-----------------TKWGSNAVMESDV 220
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*....
gi 1267806617 251 LvvervASIAEKHGIPRTHIALAWLLQKEpVTApIIGATKTSHLENAVDALSIKLTPEE 309
Cdd:cd19124 221 L-----KEIAAAKGKTVAQVSLRWVYEQG-VSL-VVKSFNKERMKQNLDIFDWELTEED 272
|
|
| AKR_AKR5C1 |
cd19130 |
Corynebacterium sp. 2,5-diketo-D-gluconic acid reductase A (DkgA) and similar proteins; ... |
39-311 |
1.67e-15 |
|
Corynebacterium sp. 2,5-diketo-D-gluconic acid reductase A (DkgA) and similar proteins; Corynebacterium sp. DkgA is a founding member of aldo-keto reductase family 5 member C1 (AKR5C1). DkgA (EC 1.1.1.346), also called 2,5-DKG reductase A, or 2,5-DKGR A, or 25DKGR-A, or AKR5C, catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG). 5-keto-D-fructose and dihydroxyacetone can also serve as substrates.
Pssm-ID: 381356 [Multi-domain] Cd Length: 256 Bit Score: 74.95 E-value: 1.67e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 39 DSRIVIKEALDLGINFFDTANVYSlgtSEEYLGRAL--KDYAnRDEVVIATKVHGQMHKGPNgsglsrkaIMSEIDKSLK 116
Cdd:cd19130 24 DTQRAVATALEVGYRHIDTAAIYG---NEEGVGAAIaaSGIP-RDELFVTTKLWNDRHDGDE--------PAAAFAESLA 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 117 RLETDYVDLYIIHrwdYDTPIE----ETMEALHDVVKAGKARYIGASamyawQFQKAlHVAEKNGWTKFVSMQNHLNLIY 192
Cdd:cd19130 92 KLGLDQVDLYLVH---WPTPAAgnyvHTWEAMIELRAAGRTRSIGVS-----NFLPP-HLERIVAATGVVPAVNQIELHP 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 193 REGEREMLPLCKEEKIGVTPYSPLASGRLTRDwsvtthrsetdqiqkskydatadsdrlvvERVASIAEKHGIPRTHIAL 272
Cdd:cd19130 163 AYQQRTIRDWAQAHDVKIEAWSPLGQGKLLGD-----------------------------PPVGAIAAAHGKTPAQIVL 213
|
250 260 270
....*....|....*....|....*....|....*....
gi 1267806617 273 AWLLQKEPVTAPiiGATKTSHLENAVDALSIKLTPEEIA 311
Cdd:cd19130 214 RWHLQKGHVVFP--KSVRRERMEDNLDVFDFDLTDTEIA 250
|
|
| AKR_AKR4C1-15 |
cd19125 |
AKR4C family of aldo-keto reductase (AKR); The AKR4C family of AKR includes aldose reductase ... |
44-277 |
3.80e-15 |
|
AKR4C family of aldo-keto reductase (AKR); The AKR4C family of AKR includes aldose reductase (ALR) from Hordeum vulgare (AKR4C1), Bromus inermis (AKR4C2), Avena fatua (AKR4C3), and Xerophyta viscosa (AKR4C4), two aldose reductases, DpAR1 (AKR4C5) and DpAR2(AKR4C6), from Digitalis purpurea, aldehyde reductase from Zea mays (AKR4C7), four aldo-keto reductases from Arabidopsis thaliana (AKR4C8-11), and another three aldo-keto reductases from Aloe arborescens (AKR4C12) and Oryza sativa (AKR4C14/15). ALR (EC 1.1.1.21), also called AR, aldehyde reductase, or polyol dehydrogenase (NADP(+)), is a cytosolic NADPH-dependent oxidoreductase that catalyzes the reduction of a variety of aldehydes and carbonyls, including monosaccharides. Both DpAR1 and DpAR2 reduce the ketone group of steroid structures. They may be involved in plant steroid metabolism in general and in cardenolide biosynthesis in particular. Plant aldo-keto reductases of the AKR4C subfamily play key roles during stress and are attractive targets for developing stress-tolerant crops.
Pssm-ID: 381351 [Multi-domain] Cd Length: 287 Bit Score: 74.30 E-value: 3.80e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 44 IKEALDLGINFFDTANVYSlgtSEEYLGRALKD-----YANRDEVVIATKVHGQMHkgpngsglSRKAIMSEIDKSLKRL 118
Cdd:cd19125 30 VKTAIKEGYRHIDCAAIYG---NEKEIGKALKKlfedgVVKREDLFITSKLWCTDH--------APEDVPPALEKTLKDL 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 119 ETDYVDLYIIHrWDY---------------DTPIEETMEALHDVVKAGKARYIGASAMYAWQFQKALHVAE--------- 174
Cdd:cd19125 99 QLDYLDLYLIH-WPVrlkkgahmpepeevlPPDIPSTWKAMEKLVDSGKVRAIGVSNFSVKKLEDLLAVARvppavnqve 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 175 -KNGWtkfvsmQNHlnliyregerEMLPLCKEEKIGVTPYSPLASGRLTrdwsvtthrsetdqiqkskydaTADSDRLVV 253
Cdd:cd19125 178 cHPGW------QQD----------KLHEFCKSKGIHLSAYSPLGSPGTT----------------------WVKKNVLKD 219
|
250 260
....*....|....*....|....
gi 1267806617 254 ERVASIAEKHGIPRTHIALAWLLQ 277
Cdd:cd19125 220 PIVTKVAEKLGKTPAQVALRWGLQ 243
|
|
| AKR_AKR2A1-2 |
cd19112 |
AKR2A family of aldo-keto reductase (AKR); The AKR2A family of AKR includes AKR2A1 ... |
33-310 |
4.91e-15 |
|
AKR2A family of aldo-keto reductase (AKR); The AKR2A family of AKR includes AKR2A1 (NADP-dependent D-sorbitol-6-phosphate dehydrogenase or NADP-S6PDH) from Malus domestica, and AKR2A2 (NADPH-dependent mannose-6-phosphate reductase or NADPH-M6PR) from Apium graveolens. NADP-S6PDH (EC 1.1.1.200), also called aldose-6-phosphate reductase [NADPH], synthesizes sorbitol-6-phosphate, a key intermediate in the synthesis of sorbitol which is a major photosynthetic product in many members of the Rosaceae family. NADPH-M6PR (EC 1.1.1.224), also called NADPH-dependent M6P reductase, is a key enzyme involved in mannitol biosynthesis.
Pssm-ID: 381338 [Multi-domain] Cd Length: 308 Bit Score: 74.44 E-value: 4.91e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 33 WVLNEDDSRIVIKEALDLGINFFDTANVYSlgtSEEYLGRALKD-----YANRDEVVIATKVHGQMHkgpngsGLSRKAI 107
Cdd:cd19112 19 WRMEPGEIKELILNAIKIGYRHFDCAADYK---NEKEVGEALAEafktgLVKREDLFITTKLWNSDH------GHVIEAC 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 108 MSeidkSLKRLETDYVDLYIIH-------------RW----------DYDTPIEETMEALHDVVKAGKARYIGASAMYAW 164
Cdd:cd19112 90 KD----SLKKLQLDYLDLYLVHfpvatkhtgvgttGSalgedgvldiDVTISLETTWHAMEKLVSAGLVRSIGISNYDIF 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 165 QFQKALhvaeknGWTKFVSMQNHLNlIYREGEREML-PLCKEEKIGVTPYSPLASGRLTRDWsvtthrsetdqiqkskYD 243
Cdd:cd19112 166 LTRDCL------AYSKIKPAVNQIE-THPYFQRDSLvKFCQKHGISVTAHTPLGGAAANAEW----------------FG 222
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1267806617 244 ATADSDRLVVErvaSIAEKHGIPRTHIALAWLLQKEpvTAPIIGATKTSHLENAVDALSIKLTPEEI 310
Cdd:cd19112 223 SVSPLDDPVLK---DLAKKYGKSAAQIVLRWGIQRN--TAVIPKSSKPERLKENIDVFDFQLSKEDM 284
|
|
| AKR_AKR5D1_E1 |
cd19132 |
AKR5D and AKR5E families of aldo-keto reductase (AKR); 2,5-diketo-D-gluconic acid reductase B ... |
33-311 |
9.85e-15 |
|
AKR5D and AKR5E families of aldo-keto reductase (AKR); 2,5-diketo-D-gluconic acid reductase B (DkgB) from Corynebacterium sp. and 2,5-diketo-D-gluconic acid reductase Zymomonas mobilis are founding members of aldo-keto reductase family 5 member D1 (AKR5D1) and E1 (AKR5E1), respectively. DkgB (EC 1.1.1.274), also called 2,5-didehydrogluconate reductase (2-dehydro-D-gluconate-forming), or 2,5-DKG reductase B, or 2,5-DKGR B, or 25DKGR-B, catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG).
Pssm-ID: 381358 [Multi-domain] Cd Length: 255 Bit Score: 72.69 E-value: 9.85e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 33 WVLNEDDSRIVIKEALDLGINFFDTANVYSlgtSEEYLGRALKDYA-NRDEVVIATKVHGQMHKgpngsglsRKAIMSEI 111
Cdd:cd19132 15 YPLKGDEGVEAVVAALQAGYRLLDTAFNYE---NEGAVGEAVRRSGvPREELFVTTKLPGRHHG--------YEEALRTI 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 112 DKSLKRLETDYVDLYIIHrWdydtPIE------ETMEALHDVVKAGKARYIGASAMYAWQFQkalHVAEKNGWTKFVSmQ 185
Cdd:cd19132 84 EESLYRLGLDYVDLYLIH-W----PNPsrdlyvEAWQALIEAREEGLVRSIGVSNFLPEHLD---RLIDETGVTPAVN-Q 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 186 NHLNLIYreGEREMLPLCKEEKIGVTPYSPLasGRltrdwsvtthrsetdqiqkskydataDSDRLVVERVASIAEKHGI 265
Cdd:cd19132 155 IELHPYF--PQAEQRAYHREHGIVTQSWSPL--GR--------------------------GSGLLDEPVIKAIAEKHGK 204
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 1267806617 266 PRTHIALAWLLQKEPVtaPIIGATKTSHLENAVDALSIKLTPEEIA 311
Cdd:cd19132 205 TPAQVVLRWHVQLGVV--PIPKSANPERQRENLAIFDFELSDEDMA 248
|
|
| AKR_AKR2D1 |
cd19115 |
AKR2D family of aldo-keto reductase (AKR); Aspergillus niger NAD(P)H-dependent D-xylose ... |
4-315 |
4.36e-13 |
|
AKR2D family of aldo-keto reductase (AKR); Aspergillus niger NAD(P)H-dependent D-xylose reductase xyl1 (XR, EC 1.1.1.307) is a founding member of aldo-keto reductase family 2 member D1 (AKR2D1). It catalyzes the initial reaction in the xylose utilization pathway by reducing D-xylose into xylitol in a NAD(P)H dependent manner.
Pssm-ID: 381341 [Multi-domain] Cd Length: 311 Bit Score: 68.60 E-value: 4.36e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 4 VKLgNTGLDVSRLclgcmGFGdankwlhQWVLNEDDSRIVIKEALDLGINFFDTANVYslGTSEEY---LGRALKD-YAN 79
Cdd:cd19115 5 VKL-NSGYDMPLV-----GFG-------LWKVNNDTCADQVYNAIKAGYRLFDGACDY--GNEVEAgqgVARAIKEgIVK 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 80 RDEVVIATKVHGQMHKGPNGSGLSRKaimseidkSLKRLETDYVDLYIIH----------------RWDYD--------T 135
Cdd:cd19115 70 REDLFIVSKLWNTFHDGERVEPICRK--------QLADWGIDYFDLFLIHfpialkyvdpavryppGWFYDgkkvefsnA 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 136 PIEETMEALHDVVKAGKARYIGASAMYAWQFQKALHVAEKNGWTkfVSMQNHLNLIyregEREMLPLCKEEKIGVTPYSP 215
Cdd:cd19115 142 PIQETWTAMEKLVDKGLARSIGVSNFSAQLLMDLLRYARIRPAT--LQIEHHPYLT----QPRLVKYAQKEGIAVTAYSS 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 216 LASgrltrdwsvtthrseTDQIQKSKYDATADSDRLVVERVASIAEKHGIPRTHIALAWLLQKEpvTAPIIGATKTSHLE 295
Cdd:cd19115 216 FGP---------------QSFLELDLPGAKDTPPLFEHDVIKSIAEKHGKTPAQVLLRWATQRG--IAVIPKSNNPKRLA 278
|
330 340
....*....|....*....|
gi 1267806617 296 NAVDALSIKLTPEEIAFLED 315
Cdd:cd19115 279 QNLDVTGFDLEAEEIKAISA 298
|
|
| AKR_AKR5H1 |
cd19134 |
AKR5H family of aldo-keto reductase (AKR); Mycobacterium smegmatis MSMEG_2407 is a founding ... |
33-313 |
6.92e-13 |
|
AKR5H family of aldo-keto reductase (AKR); Mycobacterium smegmatis MSMEG_2407 is a founding member of aldo-keto reductase family 5 member H1 (AKR5H1). It is a NADPH-dependent aldo-keto reductase that reduces methylglyoxal and phenylglyoxal.
Pssm-ID: 381360 [Multi-domain] Cd Length: 263 Bit Score: 67.57 E-value: 6.92e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 33 WVLNEDDSRIVIKEALDLGINFFDTANVYSlgtSEEYLGRAL-KDYANRDEVVIATKVHGQMHkgpnGSGLSRKAIMSei 111
Cdd:cd19134 19 GELSDDEAERSVSAALEAGYRLIDTAAAYG---NEAAVGRAIaASGIPRGELFVTTKLATPDQ----GFTASQAACRA-- 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 112 dkSLKRLETDYVDLYIIHrwdYDTPIE----ETMEALHDVVKAGKARYIGASAMyawqfqKALHVAEKNGWTKFVSMQNH 187
Cdd:cd19134 90 --SLERLGLDYVDLYLIH---WPAGREgkyvDSWGGLMKLREEGLARSIGVSNF------TAEHLENLIDLTFFTPAVNQ 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 188 LNLIYREGEREMLPLCKEEKIGVTPYSPLASGRLTRDWSVTthrsetdqiqkskydatadsdrlvvervaSIAEKHGIPR 267
Cdd:cd19134 159 IELHPLLNQAELRKVNAQHGIVTQAYSPLGVGRLLDNPAVT-----------------------------AIAAAHGRTP 209
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 1267806617 268 THIALAWLLQKEpvTAPIIGATKTSHLENAVDALSIKLTPEEIAFL 313
Cdd:cd19134 210 AQVLLRWSLQLG--NVVISRSSNPERIASNLDVFDFELTADHMDAL 253
|
|
| AKR_CeZK1290-like |
cd19135 |
Caenorhabditis elegans ZK1290.5 and similar proteins; Caenorhabditis elegans ZK1290.5 is the ... |
49-315 |
1.18e-12 |
|
Caenorhabditis elegans ZK1290.5 and similar proteins; Caenorhabditis elegans ZK1290.5 is the prototype of this family. It is an uncharacterized aldo/keto reductase family oxidoreductase.
Pssm-ID: 381361 [Multi-domain] Cd Length: 265 Bit Score: 66.96 E-value: 1.18e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 49 DLGINFFDTANVYSlgtSEEYLGRALKDYA-NRDEVVIATKvhgqMHKGPNGSGLSRKAIMSeidkSLKRLETDYVDLYI 127
Cdd:cd19135 37 ECGYRHIDTAKRYG---CEELLGKAIKESGvPREDLFLTTK----LWPSDYGYESTKQAFEA----SLKRLGVDYLDLYL 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 128 IHrWDyDTP---------IEETMEALHDVVKAGKARYIGASamyawQFQkalhVAEKNGWTKFVSMQNHLNL----IYRE 194
Cdd:cd19135 106 LH-WP-DCPssgknvketRAETWRALEELYDEGLCRAIGVS-----NFL----IEHLEQLLEDCSVVPHVNQvefhPFQN 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 195 gEREMLPLCKEEKIGVTPYSPLASGRLTRDwsvtthrsetdqiqkskydatadsdrlvvERVASIAEKHGIPRTHIALAW 274
Cdd:cd19135 175 -PVELIEYCRDNNIVFEGYCPLAKGKALEE-----------------------------PTVTELAKKYQKTPAQILIRW 224
|
250 260 270 280
....*....|....*....|....*....|....*....|.
gi 1267806617 275 LLQKEPVTAPiiGATKTSHLENAVDALSIKLTPEEIAFLED 315
Cdd:cd19135 225 SIQNGVVTIP--KSTKEERIKENCQVFDFSLSEEDMATLDS 263
|
|
| AKR_BaDH-like |
cd19129 |
Bradyrhizobium diazoefficiens dehydrogenase (DH) and similar proteins; Bradyrhizobium ... |
39-309 |
1.72e-12 |
|
Bradyrhizobium diazoefficiens dehydrogenase (DH) and similar proteins; Bradyrhizobium diazoefficiens DH is the prototype of this family. It belongs to aldo/keto reductase family.
Pssm-ID: 381355 [Multi-domain] Cd Length: 295 Bit Score: 66.71 E-value: 1.72e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 39 DSRIVIKEALDLGINFFDTANVYSlgtSEEYLGRALKDY-----ANRDEVVIATKVHGQMHKgPngsglsrKAIMSEIDK 113
Cdd:cd19129 20 ATRNAVKAALEAGFRHFDCAERYR---NEAEVGEAMQEVfkagkIRREDLFVTTKLWNTNHR-P-------ERVKPAFEA 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 114 SLKRLETDYVDLYIIH------------------RWDYDTPIE--ETMEALHDVVKAGKARYIGASAMYAWQFQKALHVA 173
Cdd:cd19129 89 SLKRLQLDYLDLYLIHtpfafqpgdeqdprdangNVIYDDGVTllDTWRAMERLVDEGRCKAIGLSDVSLEKLREIFEAA 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 174 EKNgwTKFVSMQNHLNLiyreGEREMLPLCKEEKIGVTPYSPLAsgrltrdwsvttHRSETDQIQkskydatadsDRLVV 253
Cdd:cd19129 169 RIK--PAVVQVESHPYL----PEWELLDFCKNHGIVLQAFAPLG------------HGMEPKLLE----------DPVIT 220
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*.
gi 1267806617 254 ervaSIAEKHGIPRTHIALAWLLQKEpvTAPIIGATKTSHLENAVDalsIKLTPEE 309
Cdd:cd19129 221 ----AIARRVNKTPAQVLLAWAIQRG--TALLTTSKTPSRIRENFD---ISTLPED 267
|
|
| AKR_AKR1E1-2 |
cd19110 |
AKR1E family of aldo-keto reductase (AKR); The AKR1E family of AKR includes 1, ... |
44-310 |
2.38e-12 |
|
AKR1E family of aldo-keto reductase (AKR); The AKR1E family of AKR includes 1,5-anhydro-D-fructose reductase (EC 1.1.1.263) from Mus musculus (liver, AKR1E1) and Homo sapiens (AKR1E2). 1,5-anhydro-D-fructose reductase), also called AF reductase, or aldo-keto reductase family 1 member C-like protein 2 (AKR1CL2), catalyzes the NADPH-dependent reduction of 1,5-anhydro-D-fructose (AF) to 1,5-anhydro-D-glucitol. AKR1E2 is a testis aldo-keto reductase (tAKR), which is also known as testis-specific protein (TSP), or LoopADR.
Pssm-ID: 381336 [Multi-domain] Cd Length: 301 Bit Score: 66.52 E-value: 2.38e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 44 IKEALDLGINFFDTANVYSlgtSEEYLGRALKD-----YANRDEVVIATKVHGQMHKgpngsglsRKAIMSEIDKSLKRL 118
Cdd:cd19110 23 VKVAIDAGYRHFDCAYLYH---NESEVGAGIREkikegVVRREDLFIVSKLWCTCHK--------KSLVKTACTRSLKAL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 119 ETDYVDLYIIHrW-------DYDTPIEE-------------TMEALHDVVKAGKARYIGASAMYAWQFQKALhvaEKNGw 178
Cdd:cd19110 92 KLNYLDLYLIH-WpmgfkpgEPDLPLDRsgmvipsdtdfldTWEAMEDLVIEGLVKNIGVSNFNHEQLERLL---NKPG- 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 179 TKFVSMQNHLNLIYREGEREMLPLCKEEKIGVTPYSPLASGrltrdwSVTTHRSETDQIQKskydatadsdrlvvervas 258
Cdd:cd19110 167 LRVKPVTNQIECHPYLTQKKLISFCQSRNVSVTAYRPLGGS------CEGVDLIDDPVIQR------------------- 221
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 1267806617 259 IAEKHGIPRTHIALAWLLQKEPVTAPiiGATKTSHLENAVDALSIKLTPEEI 310
Cdd:cd19110 222 IAKKHGKSPAQILIRFQIQRNVIVIP--KSVTPSRIKENIQVFDFELTEHDM 271
|
|
| dkgA |
PRK11565 |
2,5-didehydrogluconate reductase DkgA; |
33-157 |
2.76e-12 |
|
2,5-didehydrogluconate reductase DkgA;
Pssm-ID: 183203 [Multi-domain] Cd Length: 275 Bit Score: 65.86 E-value: 2.76e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 33 WVLNEDDSRIVIKEALDLGINFFDTANVYSlgtSEEYLGRALKDYA-NRDEVVIATKVHGQMHKGPngsglsRKAImsei 111
Cdd:PRK11565 23 WQASNEEVITAIHKALEVGYRSIDTAAIYK---NEEGVGKALKEASvAREELFITTKLWNDDHKRP------REAL---- 89
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 1267806617 112 DKSLKRLETDYVDLYIIHrWDyDTPIEETMEA---LHDVVKAGKARYIG 157
Cdd:PRK11565 90 EESLKKLQLDYVDLYLMH-WP-VPAIDHYVEAwkgMIELQKEGLIKSIG 136
|
|
| AKR_AKR2B1-10 |
cd19113 |
AKR2B family of aldo-keto reductase (AKR); The AKR2B family of AKR includes NAD(P)H-dependent ... |
3-311 |
5.06e-12 |
|
AKR2B family of aldo-keto reductase (AKR); The AKR2B family of AKR includes NAD(P)H-dependent D-xylose reductase (XR) from Pichia stipites, Kluyveromyces lactis, Pachysolen tannophilus, Candida tropicalis, and Candida tenuis, Gre3p from Saccharomyces cerevisiae, XR from Candida tropicalis, Pichia guilliermondii, Debaryomyces hansenli, and Debaryomyces nepalensis, which correspond to aldo-keto reductase family 2 member B1-B10 (AKR2B1-10), respectively. XR (EC1.1.1.307) catalyzes the NAD(P)H dependent reduction of xylose to xylitol.
Pssm-ID: 381339 [Multi-domain] Cd Length: 310 Bit Score: 65.55 E-value: 5.06e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 3 YVKLgNTGLDVSRLCLGCmgfgdankwlhqWVLNEDDSRIVIKEALDLGINFFDTANVYSlgtSEEYLG----RALKD-Y 77
Cdd:cd19113 2 DIKL-NSGYKMPSVGFGC------------WKLDNATAADQIYQAIKAGYRLFDGAEDYG---NEKEVGegvnRAIDEgL 65
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 78 ANRDEVVIATKVHGQMHKGPNgsglSRKAIMseidKSLKRLETDYVDLYIIH------------------------RWDY 133
Cdd:cd19113 66 VKREELFLTSKLWNNFHDPKN----VETALN----KTLSDLKLDYVDLFLIHfpiafkfvpieekyppgfycgdgdNFVY 137
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 134 -DTPIEETMEALHDVVKAGKARYIGASamyawQFQKALHVAEKNGWT-KFVSMQ--NHlnlIYREGEReMLPLCKEEKIG 209
Cdd:cd19113 138 eDVPILDTWKALEKLVDAGKIKSIGVS-----NFPGALILDLLRGATiKPAVLQieHH---PYLQQPK-LIEYAQKAGIT 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 210 VTPYSPLASGRLTrdwsvtthrsETDQiQKSKYDATADSDrlvvERVASIAEKHGIPRTHIALAWLLQKEPVTAPiigat 289
Cdd:cd19113 209 ITAYSSFGPQSFV----------ELNQ-GRALNTPTLFEH----DTIKSIAAKHNKTPAQVLLRWATQRGIAVIP----- 268
|
330 340
....*....|....*....|....*
gi 1267806617 290 KTSHLENAVDALSIK---LTPEEIA 311
Cdd:cd19113 269 KSNLPERLLQNLSVNdfdLTKEDFE 293
|
|
| AKR_AKR5B1 |
cd19127 |
AKR5B family of aldo-keto reductase (AKR); Pseudomonas putida morphine 6-dehydrogenase (M6DH) ... |
38-311 |
1.43e-11 |
|
AKR5B family of aldo-keto reductase (AKR); Pseudomonas putida morphine 6-dehydrogenase (M6DH) is a founding member of the aldo-keto reductase family 5 member B1 (AKR5B1). M6DH (EC 1.1.1.218), also called naloxone reductase, oxidizes the C-6 hydroxy group of morphine and codeine.
Pssm-ID: 381353 [Multi-domain] Cd Length: 268 Bit Score: 63.58 E-value: 1.43e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 38 DDSRIVIKEALDLGINFFDTANVYSlgtSEEYLGRALKDYA-NRDEVVIATKVHGQMHkgpnGSGLSRKAImseiDKSLK 116
Cdd:cd19127 22 EETADAVATALADGYRLIDTAAAYG---NEREVGEGIRRSGvDRSDIFVTTKLWISDY----GYDKALRGF----DASLR 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 117 RLETDYVDLYIIHrWDYDTPIEETMEALHDVVK---AGKARYIGASamyawQFQKAlHVAEKNGWTKFVSMQNHLNLIYR 193
Cdd:cd19127 91 RLGLDYVDLYLLH-WPVPNDFDRTIQAYKALEKllaEGRVRAIGVS-----NFTPE-HLERLIDATTVVPAVNQVELHPY 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 194 EGEREMLPLCKEEKIGVTPYSPLasGRLTRDWSVtthrsetdqiqkskyDATADSDRLVVERVASIAEKHGIPRTHIALA 273
Cdd:cd19127 164 FSQKDLRAFHRRLGIVTQAWSPI--GGVMRYGAS---------------GPTGPGDVLQDPTITGLAEKYGKTPAQIVLR 226
|
250 260 270 280
....*....|....*....|....*....|....*....|..
gi 1267806617 274 WLLQKEPVTAPiigatKTSH----LENaVDALSIKLTPEEIA 311
Cdd:cd19127 227 WHLQNGVSAIP-----KSVHperiAEN-IDIFDFALSAEDMA 262
|
|
| AKR_unchar |
cd19098 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
43-315 |
6.97e-11 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381324 [Multi-domain] Cd Length: 318 Bit Score: 62.36 E-value: 6.97e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 43 VIKEALDLGINFFDTANVYslGTSEEYLGRALKDYA-NRDEVVIATK----------VHGQMHKgpngsglsRKaimsei 111
Cdd:cd19098 40 VLDAAWAAGVRYFDAARSY--GRAEEFLGSWLRSRNiAPDAVFVGSKwgytytadwqVDAAVHE--------VK------ 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 112 DKSLKRL-----ET-----DYVDLYIIHRWDYDTPI---EETMEALHDVVKAGKAryIGASAMYAWQ---FQKALHVaEK 175
Cdd:cd19098 104 DHSLARLlkqweETrsllgKHLDLYQIHSATLESGVledADVLAALAELKAEGVK--IGLSLSGPQQaetLRRALEI-EI 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 176 NGWTKFVSMQNHLNLIyregER---EMLPLCKEEKIGVTPYSPLASGRLTRdwsvtthRSetdqiqkskydaTADSDRLV 252
Cdd:cd19098 181 DGARLFDSVQATWNLL----EQsagEALEEAHEAGMGVIVKEALANGRLTD-------RN------------PSPELAPL 237
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1267806617 253 VERVASIAEKHGIPRTHIALAWLLQKEPVTAPIIGATKTSHLENAVDALSIKLTPEEIAFLED 315
Cdd:cd19098 238 MAVLKAVADRLGVTPDALALAAVLAQPFVDVVLSGAATPEQLRSNLRALDVSLDLELLAALAD 300
|
|
| AKR_AKR3B1-3 |
cd19118 |
AKR3B family of aldo-keto reductase (AKR); Sporidiobolus salmonicolor NADPH-dependent aldehyde ... |
33-216 |
9.88e-11 |
|
AKR3B family of aldo-keto reductase (AKR); Sporidiobolus salmonicolor NADPH-dependent aldehyde reductase 1 (ARI, EC 1.1.1.2), Trichosporonoides megachilieni NADPH-dependent erthyrose reductase (ER) 1/2 and 3, are founding members of aldo-keto reductase family 3 member B1 (AKR3B1), B2 (AKR3B2), and B3 (AKR3B3), respectively. Sporidiobolus salmonicolor NADPH-ARI, also called alcohol dehydrogenase [NADP(+)], or aldehyde reductase I, or ALR 1, catalyzes the asymmetric reduction of aliphatic and aromatic aldehydes and ketones to an R-enantiomer. It reduces ethyl 4-chloro-3-oxobutanoate to ethyl (R)-4-chloro-3-hydroxybutanoate. Trichosporonoides megachilieni NADPH-ERs catalyze the reduction of D-erythrose.
Pssm-ID: 381344 [Multi-domain] Cd Length: 283 Bit Score: 61.27 E-value: 9.88e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 33 WVLNEDDSRIVIKEALDLGINFFDTANVYSlgtSEEYLGRALKDY------ANRDEVVIATKVHGQMHKgpngsglsRKA 106
Cdd:cd19118 15 WQAEPGEVGAAVKIALKAGYRHLDLAKVYQ---NQHEVGQALKELlkeepgVKREDLFITSKLWNNSHR--------PEY 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 107 IMSEIDKSLKRLETDYVDLYIIHrW-------------------------DYDTPIEETMEALHDVVKAGKARYIGASAM 161
Cdd:cd19118 84 VEPALDDTLKELGLDYLDLYLIH-WpvafkptgdlnpltavptnggevdlDLSVSLVDTWKAMVELKKTGKVKSIGVSNF 162
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 1267806617 162 YAWQFQKalhVAEKNGWTKFVS-MQNHLNLIyregEREMLPLCKEEKIGVTPYSPL 216
Cdd:cd19118 163 SIDHLQA---IIEETGVVPAVNqIEAHPLLL----QDELVDYCKSKNIHITAYSPL 211
|
|
| AKR_AKR1C1-35 |
cd19108 |
AKR1C family of aldo-keto reductase (AKR); The AKR1C family of aldo-keto reductase (AKR) ... |
43-281 |
2.07e-10 |
|
AKR1C family of aldo-keto reductase (AKR); The AKR1C family of aldo-keto reductase (AKR) includes AKR1C1 (20-alpha-hydroxysteroid dehydrogenase, also known as 20alpha-HSD), AKR1C2 (3alpha-HSD type 3), AKR1C3 (17beta-HSD type 5), and AKR1C4 (3alpha-HSD type 1) from Homo sapiens; AKR1C5 (20alpha-HSD, also known as prostaglandin-E(2) 9-reductase) from Rattus norvegicus (ovary); AKR1C6 (estradiol 17beta-HSD type 5) from Mus musculus; AKR1C7 (prostaglandin F synthase 1 or PGF1) from Bos taurus (lung); AKR1C8 (20alpha-HSD) from Rattus norvegicus (ovary); AKR1C9 (3alpha-HSD) from Rattus norvegicus (liver); AKR1C10a (Rho crystallin) from Rana temporaria and AKR1C10b (Rho crystallin) from Rana catesbeina; AKR1C11 (prostaglandin F synthase 2 or PGF2) from Bos taurus (liver); AKR1C12 (aldo-keto reductase or AKR), AKR1C13 (interleukin-3-regulated AKR), and AKR1C14 (3alpha-HSD) from Mus musculus; AKR1C15 (NADPH-dependent reductase), AKR1C16 (NAD+-preferring 3alpha/17beta/20alpha-HSD), and AKR1C17 (NAD+-dependent 3alpha-HSD) from Rattus norvegicus; AKR1C18 (20alpha-HSD), AKR1C19 (3-hydroxybutyrate dehydrogenase or 3HB dehydrogenase), AKR1C20 (3alpha(17beta)-HSD), AKR1C21 (3(17)alpha-HSD), AKR1C22 (dihydrodiol dehydrogenase or DD) from Mus musculus; AKR1C23 (20alpha-HSD) from Equus caballus; AKR1C24 (NAD+-dependent 17beta-HSD) from Rattus norvegicus; AKR1C25 (3(20)alpha-HSD) from Macaca fuscata; AKR1C26 (identical to morphine 6-dehydrogenase or M6DH, acts as NAD(+)-dependent 3alpha/17beta-HSD), AKR1C27/AKR1C28 (NAD(+)-dependent 3alpha/17beta-HSDs), AKR1C29 (identical to 3-hydroxyhexobarbital dehydrogenase or 3HBD, acts as NADPH-preferring reductase with 3alpha/3beta/17beta/20alpha-HSD activity), AKR1C30 (identical to naloxone reductase type 1 and acts as 17beta-HSD), AKR1C31 (3alpha/17beta/20alpha-HSD), AKR1C32 (identical to loxoprofen reductase and acts as 3alpha/20alpha-HSD), and AKR1C33 (identical to naloxone reductase type 2 and mainly acts as 3alpha-HSD) from Oryctolagus cuniculus; AKR1C34 (NAD+-dependent morphine 6-dehydrogenase or M6DH with 3beta/17beta/20alpha-HSD activity) and AKR1C35 (NAD+-dependent dehydrogenase with 3(17)beta-HSD activity) from Mesocricetus auratus.
Pssm-ID: 381334 [Multi-domain] Cd Length: 303 Bit Score: 60.71 E-value: 2.07e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 43 VIKEALDLGINFFDTANVYSlgtSEEYLGRALKD-----YANRDEVVIATKVHGQMHKgPNgsgLSRKAImseiDKSLKR 117
Cdd:cd19108 32 ATKLAIDAGFRHIDSAYLYQ---NEEEVGQAIRSkiadgTVKREDIFYTSKLWCTFHR-PE---LVRPAL----EKSLKK 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 118 LETDYVDLYIIH------------------RWDYDT-PIEETMEALHDVVKAGKARYIGASAMYAWQFQKALHvaeKNGw 178
Cdd:cd19108 101 LQLDYVDLYLIHfpvalkpgeelfpkdengKLIFDTvDLCATWEAMEKCKDAGLAKSIGVSNFNRRQLEMILN---KPG- 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 179 TKFVSMQN----HLNLiyreGEREMLPLCKEEKIGVTPYSPLASGRLTRdWsvtthrseTDQiqkskydataDSDRLVVE 254
Cdd:cd19108 177 LKYKPVCNqvecHPYL----NQSKLLDFCKSKDIVLVAYSALGSQRDKE-W--------VDQ----------NSPVLLED 233
|
250 260
....*....|....*....|....*...
gi 1267806617 255 RV-ASIAEKHGIPRTHIALAWLLQKEPV 281
Cdd:cd19108 234 PVlCALAKKHKRTPALIALRYQLQRGVV 261
|
|
| AKR_AKR3C1 |
cd19119 |
Saccharomyces cerevisiae D-arabinose dehydrogenase [NAD(P)+] heavy chain (Ara1p) and similar ... |
2-315 |
2.23e-10 |
|
Saccharomyces cerevisiae D-arabinose dehydrogenase [NAD(P)+] heavy chain (Ara1p) and similar proteins; Saccharomyces cerevisiae Ara1p (EC 1.1.1.117), also called D-arabinose 1-dehydrogenase (NAD(P)(+)), is a founding members of aldo-keto reductase family 3 member C1 (AKR3C1). It catalyzes the oxidation of D-arabinose, L-xylose, L-fucose, and L-galactose in the presence of NADP(+).
Pssm-ID: 381345 [Multi-domain] Cd Length: 294 Bit Score: 60.59 E-value: 2.23e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 2 KYVKLgNTGLDVSRLCLGcmgfgdankwlhQWVLNEDDSRI--VIKEALDLGINFFDTANVYSlgtSEEYLGRALKDY-- 77
Cdd:cd19119 2 ISFKL-NTGASIPALGLG------------TASPHEDRAEVkeAVEAAIKEGYRHIDTAYAYE---TEDFVGEAIKRAid 65
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 78 ---ANRDEVVIATKVHGQMHKGPNGSglsrkaimseIDKSLKRLETDYVDLYIIH------------------------- 129
Cdd:cd19119 66 dgsIKREELFITTKVWPTFYDEVERS----------LDESLKALGLDYVDLLLVHwpvcfekdsddsgkpftpvnddgkt 135
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 130 RWDYDTPIEETMEALHDVVKAGKARYIGASAMYAWQFQKALHVAekngwtKFVSMQNHLNLIYREGEREMLPLCKEEKIG 209
Cdd:cd19119 136 RYAASGDHITTYKQLEKIYLDGRAKAIGVSNYSIVYLERLIKEC------KVVPAVNQVELHPHLPQMDLRDFCFKHGIL 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 210 VTPYSPLASGRltrdwsvtthrsetdqiqkskydatadSDRLVVERVASIAEKHGIPRTHIALAWLLQKEPVTAPiigat 289
Cdd:cd19119 210 VTAYSPLGSHG---------------------------APNLKNPLVKKIAEKYNVSTGDILISYHVRQGVIVLP----- 257
|
330 340
....*....|....*....|....*..
gi 1267806617 290 KTSHLENAVDALSI-KLTPEEIAFLED 315
Cdd:cd19119 258 KSLKPVRIVSNGKIvSLTKEDLQKLDD 284
|
|
| AKR_AKR2C1 |
cd19114 |
AKR2C family of aldo-keto reductase (AKR); Mucor mucedo NADP-dependent ... |
33-309 |
2.01e-09 |
|
AKR2C family of aldo-keto reductase (AKR); Mucor mucedo NADP-dependent 4-dihydromethyl-trisporate dehydrogenase (TDH), also called 4-dihydromethyltrisporate dehydrogenase, or 4-dihydromethyl-TA dehydrogenase, is a founding member of aldo-keto reductase family 2 member C1 (AKR2C1). It is involved in the biosynthesis of trisporic acid, the sexual hormone of zygomycetes, which induces the first steps of zygophore development. TDH catalyzes the NADP-dependent oxidation of (+) mating-type specific precursor 4-dihydromethyl-trisporate to methyl-trisporate.
Pssm-ID: 381340 [Multi-domain] Cd Length: 302 Bit Score: 57.57 E-value: 2.01e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 33 WVLNEDDSRIVIKEALDLGINFFDTANVYSlgtSEEYLGRALKDYAN-----RDEVVIATKVHGQMHkgpngsglSRKAI 107
Cdd:cd19114 12 AKIKANETEEVIYNAIKVGYRLIDGALLYG---NEAEVGRGIRKAIQeglvkREDLFIVTKLWNNFH--------GKDHV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 108 MSEIDKSLKRLETDYVDLYIIH--------------------------RWDyDTPIEETMEALHDVVKAGKARYIGASAM 161
Cdd:cd19114 81 REAFDRQLKDYGLDYIDLYLIHfpipaayvdpaenypflwkdkelkkfPLE-QSPMQECWREMEKLVDAGLVRNIGIANF 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 162 YAWQFQKALHVAEKNGWTKFVSMQNHLNliyregEREMLPLCKEEKIGVTPYSPLASGRLTRdwsVTTHRSETDQIQKSk 241
Cdd:cd19114 160 NVQLILDLLTYAKIKPAVLQIEHHPYLQ------QKRLIDWAKKQGIQITAYSSFGNAVYTK---VTKHLKHFTNLLEH- 229
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1267806617 242 ydatadsdrlvvERVASIAEKHGIPRTHIALAWLLQKEPVTAPiiGATKTSHLENAVDALSIKLTPEE 309
Cdd:cd19114 230 ------------PVVKKLADKHKRDTGQVLLRWAVQRNITVIP--KSVNVERMKTNLDITSYKLDEED 283
|
|
| AKR_AKR1B1-19 |
cd19107 |
AKR1B family of aldo-keto reductase (AKR); The AKR1B family of AKR includes aldose reductase ... |
43-218 |
2.83e-09 |
|
AKR1B family of aldo-keto reductase (AKR); The AKR1B family of AKR includes aldose reductase (AR, EC 1.1.1.21) from Homo sapiens (AKR1B1), Oryctolagus cuniculus (kidney, AKR1B2), Mus musculus (AKR1B3), Rattus norvegicus (lens, AKR1B4), Bos taurus (lens/testis, AKR1B5), and Sus scrofa (lens, AKR1B6), aldose reductase-related protein 1 (ALD1, EC1.1.1.21) from Mus musculus (AKR1B7), Rattus norvegicus (AKR1B14), and Homo sapiens (AKR1B15), Mus musculus fibroblast growth factor induced protein (FR-1 or AKR1B8, EC 1.1.1.21), Cricetulus griseus aldose reductase-related protein 2 (ALD2 or AKR1B9, EC 1.1.1.21), aldose reductase-like from Homo sapiens (ARL-1 or AKR1B10) and Rattus norvegicus (AKR1B13), aldo-keto reductase from Gallus domesticus (eye, tongue, esophagus, AKR1B12), and Oryctolagus cuniculus AR-like protein (3beta-HSD, AKR1B19). AR, also called aldehyde reductase, catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies. ALD1 reduces a broad range of aliphatic and aromatic aldehydes to the corresponding alcohols. It may play a role in the metabolism of xenobiotic aromatic aldehydes. FR-1, also called aldose reductase-related protein 2, or fibroblast growth factor-regulated protein (FGFRP), is induced by fibroblast growth factor-1. It may play a role in the regulation of the cell cycle. FR-1 belongs to the NADPH-dependent aldo-keto reductase family. ALD2 is an inducible aldo-keto reductase with a preference for aliphatic substrates. It can also act on small aromatic aldehydes, steroid aldehydes and some ketone substrates. ARL-1, also called aldose reductase-like, or aldose reductase-related protein (ARP), or small intestine reductase, or SI reductase, acts as all-trans-retinaldehyde reductase that can efficiently reduce aliphatic and aromatic aldehydes, and is less active on hexoses (in vitro). It may be responsible for detoxification of reactive aldehydes in the digested food before the nutrients are passed on to other organs. AKR1B15, also called estradiol 17-beta-dehydrogenase AKR1B15, is a mitochondrial aldo-keto reductase that catalyzes the reduction of androgens and estrogens with high positional selectivity (shows 17-beta-hydroxysteroid dehydrogenase activity) as well as 3-keto-acyl-CoAs. It has a strong selectivity towards NADP(H). AKR1B19 is aldose reductase-like that may show 3-beta-hydroxysteroid dehydrogenase (3beta-HSD) activity.
Pssm-ID: 381333 [Multi-domain] Cd Length: 307 Bit Score: 57.43 E-value: 2.83e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 43 VIKEALDLGINFFDTANVYSlgtSEEYLGRALKDYAN-----RDEVVIATKVHGQMHKGPngsgLSRKAImseiDKSLKR 117
Cdd:cd19107 22 AVKVAIDAGYRHIDCAYVYQ---NENEVGEAIQEKIKeqvvkREDLFIVSKLWCTFHEKG----LVKGAC----QKTLSD 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 118 LETDYVDLYIIHrW--------DY------------DTPIEETMEALHDVVKAGKARYIGASAMYAWQFQKALHvaeKNG 177
Cdd:cd19107 91 LKLDYLDLYLIH-WptgfkpgkELfpldesgnvipsDTTFLDTWEAMEELVDEGLVKAIGVSNFNHLQIERILN---KPG 166
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 1267806617 178 wTKFVSMQNHLNLIYREGEREMLPLCKEEKIGVTPYSPLAS 218
Cdd:cd19107 167 -LKYKPAVNQIECHPYLTQEKLIQYCQSKGIVVTAYSPLGS 206
|
|
| AKR_AKR3E1 |
cd19122 |
AKR3E family of aldo-keto reductase (AKR); Trichoderma reesei NADP(+)-dependent glycerol ... |
47-284 |
4.73e-09 |
|
AKR3E family of aldo-keto reductase (AKR); Trichoderma reesei NADP(+)-dependent glycerol 2-dehydrogenase (GLD2, EC 1.1.1.156), also called dihydroxyacetone reductase, is a founding member of aldo-keto reductase family 3 member E1 (AKR3E1). It acts as a glycerol oxidoreductase probably involved in glycerol synthesis.
Pssm-ID: 381348 [Multi-domain] Cd Length: 291 Bit Score: 56.48 E-value: 4.73e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 47 ALDLGINFFDTANVYslgTSEEYLGRALKDY------ANRDEVVIATKVHGQMHKgpngsglsRKAIMSEIDKSLKRLET 120
Cdd:cd19122 33 ALDVGYRHLDCAWFY---LNEDEVGDAVRDFlkenpsVKREDLFICTKVWNHLHE--------PEDVKWSIDNSLKNLKL 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 121 DYVDLYIIHrW-------DYDTPI-----------------EETMEALHDVVKAGKARYIGASAMYAWQFQKALhvaekn 176
Cdd:cd19122 102 DYIDLFLVH-WpiaaeknDQRSPKlgpdgkyvilkdltenpEPTWRAMEEIYESGKAKAIGVSNWTIPGLKKLL------ 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 177 gwtKFVSMQNHLNLIYRE---GEREMLPLCKEEKIGVTPYSPLASgrlTRDWSVTTHRSETDQIQKskydatadsdrlvv 253
Cdd:cd19122 175 ---SFAKVKPHVNQIEIHpflPNEELVDYCFSNDILPEAYSPLGS---QNQVPSTGERVSENPTLN-------------- 234
|
250 260 270
....*....|....*....|....*....|.
gi 1267806617 254 ervaSIAEKHGIPRTHIALAWLLQKEPVTAP 284
Cdd:cd19122 235 ----EVAEKGGYSLAQVLIAWGLRRGYVVLP 261
|
|
| AKR_AKR1D1-3 |
cd19109 |
AKR1D family of aldo-keto reductase (AKR); The AKR1D family of aldo-keto reductase includes ... |
44-220 |
4.70e-08 |
|
AKR1D family of aldo-keto reductase (AKR); The AKR1D family of aldo-keto reductase includes 3-oxo-5-beta-steroid 4-dehydrogenase (EC 1.3.1.3) from Homo sapiens (AKR1D1), Rattus norvegicus (liver, AKR1D2), and Oryctolagus cuniculus (AKR1D3). 3-oxo-5-beta-steroid 4-dehydrogenase, also called delta(4)-3-ketosteroid 5-beta-reductase (EC 1.3.99.6), or delta(4)-3-oxosteroid 5-beta-reductase, or 5-beta-reductase, efficiently catalyzes the reduction of progesterone, androstenedione, 17-alpha-hydroxyprogesterone and testosterone to 5-beta-reduced metabolites.
Pssm-ID: 381335 [Multi-domain] Cd Length: 308 Bit Score: 53.65 E-value: 4.70e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 44 IKEALDLGINFFDTANVYSlgtSEEYLGRALKD-----YANRDEVVIATKVHGQMHKgPNgsgLSRKAImseiDKSLKRL 118
Cdd:cd19109 27 VKVAIDTGYRHIDGAYIYQ---NEHEVGQAIREkiaegKVKREDIFYCGKLWNTCHP-PE---LVRPTL----ERTLKVL 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1267806617 119 ETDYVDLYIIH------------------RWDYD-TPIEETMEALHDVVKAGKARYIGASAMYAWQFQKALHvaeKNGwT 179
Cdd:cd19109 96 QLDYVDLYIIEmpmafkpgdeiyprdengKWLYHkTNLCATWEALEACKDAGLVKSIGVSNFNRRQLELILN---KPG-L 171
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 1267806617 180 KFVSMQNHLNLIYREGEREMLPLCKEEKIGVTPYSPLASGR 220
Cdd:cd19109 172 KHKPVSNQVECHPYFTQPKLLEFCQQHDIVIVAYSPLGTCR 212
|
|
| |
