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Conserved domains on  [gi|1268853653|ref|WP_099065384.1|]
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winged helix-turn-helix transcriptional regulator

Protein Classification

winged helix-turn-helix transcriptional regulator( domain architecture ID 10004391)

winged helix-turn-helix (HTH) transcriptional regulator containing a HxlR family HTH domain; similar to HTH-type transcriptional regulator HxlR, a DNA-binding protein that acts as a positive regulator of the formaldehyde-inducible hxlAB operon

CATH:  1.10.10.10
Gene Ontology:  GO:0003677
PubMed:  15808743|10679470|10908318

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HxlR COG1733
DNA-binding transcriptional regulator, HxlR family [Transcription];
6-101 5.01e-46

DNA-binding transcriptional regulator, HxlR family [Transcription];


:

Pssm-ID: 441339  Cd Length: 108  Bit Score: 143.85  E-value: 5.01e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1268853653   6 KKASCPVEITLKVIGGKWKVLIIHFLLEGTKRFGELTRCLGPISPKILAQQLRELEEDGLVIRKDFGEIPPRVEYAMSSL 85
Cdd:COG1733     6 KEADCPVRRALDVIGGKWKLLILRALLDGPRRFGELRRSLPGISQKMLTQRLRELEEDGLVERTVYPEVPPRVEYSLTEK 85

                          90
                  ....*....|....*.
gi 1268853653  86 GNTLSPILYAMADWGD 101
Cdd:COG1733    86 GRSLLPVLDALAEWGE 101
 
Name Accession Description Interval E-value
HxlR COG1733
DNA-binding transcriptional regulator, HxlR family [Transcription];
6-101 5.01e-46

DNA-binding transcriptional regulator, HxlR family [Transcription];


Pssm-ID: 441339  Cd Length: 108  Bit Score: 143.85  E-value: 5.01e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1268853653   6 KKASCPVEITLKVIGGKWKVLIIHFLLEGTKRFGELTRCLGPISPKILAQQLRELEEDGLVIRKDFGEIPPRVEYAMSSL 85
Cdd:COG1733     6 KEADCPVRRALDVIGGKWKLLILRALLDGPRRFGELRRSLPGISQKMLTQRLRELEEDGLVERTVYPEVPPRVEYSLTEK 85

                          90
                  ....*....|....*.
gi 1268853653  86 GNTLSPILYAMADWGD 101
Cdd:COG1733    86 GRSLLPVLDALAEWGE 101
HxlR pfam01638
HxlR-like helix-turn-helix; HxlR, a member of this family, is a DNA-binding protein that acts ...
 18-101 7.13e-35

HxlR-like helix-turn-helix; HxlR, a member of this family, is a DNA-binding protein that acts as a positive regulator of the formaldehyde-inducible hxlAB operon in Bacillus subtilis.


Pssm-ID: 460276 [Multi-domain]  Cd Length: 91  Bit Score: 115.09  E-value: 7.13e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1268853653  18 VIGGKWKVLIIHFLLEGTKRFGELTRCLGPISPKILAQQLRELEEDGLVIRKDFGEIPPRVEYAMSSLGNTLSPILYAMA 97
Cdd:pfam01638   1 LIGGKWKGLILRELLDGKKRFSELKRAIPGITQKMLTQRLRELEQDGIINREVYPEVPPKVEYSLTEKGRSLEPILQELC 80


                  ....
gi 1268853653  98 DWGD 101
Cdd:pfam01638  81 DWGE 84
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 16-72 2.45e-07

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 44.60  E-value: 2.45e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1268853653  16 LKVIGGKWKVLIIHFLLEGTKRFGELTRCLGpISPKILAQQLRELEEDGLVIRKDFG 72
Cdd:cd00090     1 LKALSDPTRLRILRLLLEGPLTVSELAERLG-LSQSTVSRHLKKLEEAGLVESRREG 56
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
27-72 9.43e-04

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 34.88  E-value: 9.43e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 1268853653   27 IIHFLLEGTKRFGELTRCLGpISPKILAQQLRELEEDGLVIRKDFG 72
Cdd:smart00418   2 ILKLLAEGELCVCELAEILG-LSQSTVSHHLKKLREAGLVESRREG 46
 
Name Accession Description Interval E-value
HxlR COG1733
DNA-binding transcriptional regulator, HxlR family [Transcription];
6-101 5.01e-46

DNA-binding transcriptional regulator, HxlR family [Transcription];


Pssm-ID: 441339  Cd Length: 108  Bit Score: 143.85  E-value: 5.01e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1268853653   6 KKASCPVEITLKVIGGKWKVLIIHFLLEGTKRFGELTRCLGPISPKILAQQLRELEEDGLVIRKDFGEIPPRVEYAMSSL 85
Cdd:COG1733     6 KEADCPVRRALDVIGGKWKLLILRALLDGPRRFGELRRSLPGISQKMLTQRLRELEEDGLVERTVYPEVPPRVEYSLTEK 85

                          90
                  ....*....|....*.
gi 1268853653  86 GNTLSPILYAMADWGD 101
Cdd:COG1733    86 GRSLLPVLDALAEWGE 101
HxlR pfam01638
HxlR-like helix-turn-helix; HxlR, a member of this family, is a DNA-binding protein that acts ...
 18-101 7.13e-35

HxlR-like helix-turn-helix; HxlR, a member of this family, is a DNA-binding protein that acts as a positive regulator of the formaldehyde-inducible hxlAB operon in Bacillus subtilis.


Pssm-ID: 460276 [Multi-domain]  Cd Length: 91  Bit Score: 115.09  E-value: 7.13e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1268853653  18 VIGGKWKVLIIHFLLEGTKRFGELTRCLGPISPKILAQQLRELEEDGLVIRKDFGEIPPRVEYAMSSLGNTLSPILYAMA 97
Cdd:pfam01638   1 LIGGKWKGLILRELLDGKKRFSELKRAIPGITQKMLTQRLRELEQDGIINREVYPEVPPKVEYSLTEKGRSLEPILQELC 80


                  ....
gi 1268853653  98 DWGD 101
Cdd:pfam01638  81 DWGE 84
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 16-72 2.45e-07

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 44.60  E-value: 2.45e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1268853653  16 LKVIGGKWKVLIIHFLLEGTKRFGELTRCLGpISPKILAQQLRELEEDGLVIRKDFG 72
Cdd:cd00090     1 LKALSDPTRLRILRLLLEGPLTVSELAERLG-LSQSTVSRHLKKLEEAGLVESRREG 56
HTH_5 pfam01022
Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding ...
 24-66 3.47e-05

Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding 'helix-turn-helix' motif. This family includes other proteins which are not included in the Prosite definition.


Pssm-ID: 425993 [Multi-domain]  Cd Length: 45  Bit Score: 38.19  E-value: 3.47e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1268853653  24 KVLIIHFLLEGTKRFGELTRCLGpISPKILAQQLRELEEDGLV 66
Cdd:pfam01022   4 RLKILKLLAEGELCVCELAEELG-LSQSTVSHHLKKLREAGLV 45
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
15-70 1.69e-04

DNA-binding transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 37.56  E-value: 1.69e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1268853653  15 TLKVIGGKWKVLIIHFLLEGTKRFGELTRCLGpISPKILAQQLRELEEDGLVI-RKD 70
Cdd:COG0640    13 LFKALADPTRLRILRLLAEGELCVGELAEALG-LSQSTVSHHLKVLREAGLVTsRRE 68
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
27-72 9.43e-04

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 34.88  E-value: 9.43e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 1268853653   27 IIHFLLEGTKRFGELTRCLGpISPKILAQQLRELEEDGLVIRKDFG 72
Cdd:smart00418   2 ILKLLAEGELCVCELAEILG-LSQSTVSHHLKKLREAGLVESRREG 46
COG4742 COG4742
Predicted transcriptional regulator, contains HTH domain [Transcription];
27-70 2.95e-03

Predicted transcriptional regulator, contains HTH domain [Transcription];


Pssm-ID: 443776 [Multi-domain]  Cd Length: 267  Bit Score: 35.64  E-value: 2.95e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1268853653  27 IIHFLLEGTKRFGELTRCLGpISPKILAQQLRELEEDGLVIRKD 70
Cdd:COG4742    21 ILLLLAEGPKTRSELAESLD-VSRSTILRQLKELEERGLIERDD 63
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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