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Conserved domains on  [gi|1271567899|ref|WP_099346893|]
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MULTISPECIES: DUF739 family protein [Clostridium]

Protein Classification

helix-turn-helix domain-containing protein( domain architecture ID 366238)

helix-turn-helix (HTH) domain-containing protein with an XRE (Xenobiotic Response Element) family; HTH domain binds DNA and may function as a transcriptional regulator

Gene Ontology:  GO:0003677|GO:0006355

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
HTH_XRE super family cl22854
Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the ...
1-67 2.35e-22

Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.


The actual alignment was detected with superfamily member pfam05339:

Pssm-ID: 473980  Cd Length: 68  Bit Score: 81.04  E-value: 2.35e-22
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1271567899  1 MAFNYDKLRGKIVEKYGAQYRFAKALGVSERTLSLKLNNKIFFSQDEITKISELLNIESCEIQVYFF 67
Cdd:pfam05339  1 MSYDYSSLLGKITEKYGTQYNFAIAMGLSERSLSLKLNDKVTWKDDEILKAVHLLDLNPQKIPKYFF 67
 
Name Accession Description Interval E-value
DUF739 pfam05339
Protein of unknown function (DUF739); This family contains several bacteriophage proteins. ...
1-67 2.35e-22

Protein of unknown function (DUF739); This family contains several bacteriophage proteins. Some of the proteins in this family have been labeled putative cro repressor proteins.


Pssm-ID: 428429  Cd Length: 68  Bit Score: 81.04  E-value: 2.35e-22
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1271567899  1 MAFNYDKLRGKIVEKYGAQYRFAKALGVSERTLSLKLNNKIFFSQDEITKISELLNIESCEIQVYFF 67
Cdd:pfam05339  1 MSYDYSSLLGKITEKYGTQYNFAIAMGLSERSLSLKLNDKVTWKDDEILKAVHLLDLNPQKIPKYFF 67
XRE COG1476
DNA-binding transcriptional regulator, XRE-family HTH domain [Transcription];
19-62 3.17e-03

DNA-binding transcriptional regulator, XRE-family HTH domain [Transcription];


Pssm-ID: 441085 [Multi-domain]  Cd Length: 68  Bit Score: 32.51  E-value: 3.17e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 1271567899 19 QYRFAKALGVSERTLSLKLNNKIFFSQDEITKISELLNIESCEI 62
Cdd:COG1476   20 QEELAELLGVSRQTISAIENGKYNPSLELALKIARALGVSLEEL 63
 
Name Accession Description Interval E-value
DUF739 pfam05339
Protein of unknown function (DUF739); This family contains several bacteriophage proteins. ...
1-67 2.35e-22

Protein of unknown function (DUF739); This family contains several bacteriophage proteins. Some of the proteins in this family have been labeled putative cro repressor proteins.


Pssm-ID: 428429  Cd Length: 68  Bit Score: 81.04  E-value: 2.35e-22
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1271567899  1 MAFNYDKLRGKIVEKYGAQYRFAKALGVSERTLSLKLNNKIFFSQDEITKISELLNIESCEIQVYFF 67
Cdd:pfam05339  1 MSYDYSSLLGKITEKYGTQYNFAIAMGLSERSLSLKLNDKVTWKDDEILKAVHLLDLNPQKIPKYFF 67
XRE COG1476
DNA-binding transcriptional regulator, XRE-family HTH domain [Transcription];
19-62 3.17e-03

DNA-binding transcriptional regulator, XRE-family HTH domain [Transcription];


Pssm-ID: 441085 [Multi-domain]  Cd Length: 68  Bit Score: 32.51  E-value: 3.17e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 1271567899 19 QYRFAKALGVSERTLSLKLNNKIFFSQDEITKISELLNIESCEI 62
Cdd:COG1476   20 QEELAELLGVSRQTISAIENGKYNPSLELALKIARALGVSLEEL 63
VapI COG3093
Plasmid maintenance system antidote protein VapI, contains XRE-type HTH domain [Defense ...
19-57 6.47e-03

Plasmid maintenance system antidote protein VapI, contains XRE-type HTH domain [Defense mechanisms];


Pssm-ID: 442327 [Multi-domain]  Cd Length: 87  Bit Score: 32.09  E-value: 6.47e-03
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 1271567899 19 QYRFAKALGVSERTLSLKLNNKIFFSQDEITKISELLNI 57
Cdd:COG3093   25 QTELAKALGVSRQRISEILNGKRAITADTALRLARAFGT 63
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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