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Conserved domains on  [gi|1273035710|ref|WP_099434508|]
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MULTISPECIES: HNH/ENDO VII family nuclease [Pseudomonas]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LHH super family cl16861
A nuclease of the HNH/ENDO VII superfamily with conserved LHH; LHH is a predicted nuclease of ...
 3-87 2.62e-06

A nuclease of the HNH/ENDO VII superfamily with conserved LHH; LHH is a predicted nuclease of the HNH/ENDO VII superfamily of the treble clef fold. The name is derived from the conserved motif, LHH. It is found in bacterial polymorphic toxin systems and functions as a toxin module. Like WHH and AHH, LHH nuclease contain 4 conserved histidines of which, the first one is predicted to bind metal-ion and other three ones are involved in activation of water molecule for hydrolysis.


The actual alignment was detected with superfamily member pfam14411:

Pssm-ID: 433940  Cd Length: 76  Bit Score: 41.18  E-value: 2.62e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1273035710  3 NLDRAKEGGAPYImKDGvpQQLQLHHSRQNGKGPLFELSRKTHlttlKGKGREAvhpygHNQHPDAPVDRELFKKEVPQY 82
Cdd:pfam14411  2 NLELMEKGNAPID-NDG--KPINLHHIGQKEDGPLAELTKSEH----KDNHKIL-----HESFRPSQIDRKEFEKFRRAY 69


                 ....*
gi 1273035710 83 WKDRA 87
Cdd:pfam14411 70 WKWRA 74
 
Name Accession Description Interval E-value
LHH pfam14411
A nuclease of the HNH/ENDO VII superfamily with conserved LHH; LHH is a predicted nuclease of ...
 3-87 2.62e-06

A nuclease of the HNH/ENDO VII superfamily with conserved LHH; LHH is a predicted nuclease of the HNH/ENDO VII superfamily of the treble clef fold. The name is derived from the conserved motif, LHH. It is found in bacterial polymorphic toxin systems and functions as a toxin module. Like WHH and AHH, LHH nuclease contain 4 conserved histidines of which, the first one is predicted to bind metal-ion and other three ones are involved in activation of water molecule for hydrolysis.


Pssm-ID: 433940  Cd Length: 76  Bit Score: 41.18  E-value: 2.62e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1273035710  3 NLDRAKEGGAPYImKDGvpQQLQLHHSRQNGKGPLFELSRKTHlttlKGKGREAvhpygHNQHPDAPVDRELFKKEVPQY 82
Cdd:pfam14411  2 NLELMEKGNAPID-NDG--KPINLHHIGQKEDGPLAELTKSEH----KDNHKIL-----HESFRPSQIDRKEFEKFRRAY 69


                 ....*
gi 1273035710 83 WKDRA 87
Cdd:pfam14411 70 WKWRA 74
 
Name Accession Description Interval E-value
LHH pfam14411
A nuclease of the HNH/ENDO VII superfamily with conserved LHH; LHH is a predicted nuclease of ...
 3-87 2.62e-06

A nuclease of the HNH/ENDO VII superfamily with conserved LHH; LHH is a predicted nuclease of the HNH/ENDO VII superfamily of the treble clef fold. The name is derived from the conserved motif, LHH. It is found in bacterial polymorphic toxin systems and functions as a toxin module. Like WHH and AHH, LHH nuclease contain 4 conserved histidines of which, the first one is predicted to bind metal-ion and other three ones are involved in activation of water molecule for hydrolysis.


Pssm-ID: 433940  Cd Length: 76  Bit Score: 41.18  E-value: 2.62e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1273035710  3 NLDRAKEGGAPYImKDGvpQQLQLHHSRQNGKGPLFELSRKTHlttlKGKGREAvhpygHNQHPDAPVDRELFKKEVPQY 82
Cdd:pfam14411  2 NLELMEKGNAPID-NDG--KPINLHHIGQKEDGPLAELTKSEH----KDNHKIL-----HESFRPSQIDRKEFEKFRRAY 69


                 ....*
gi 1273035710 83 WKDRA 87
Cdd:pfam14411 70 WKWRA 74
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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