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Conserved domains on  [gi|1275611278|ref|WP_099704284|]
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MULTISPECIES: IS3 family transposase [Enterococcus]

Protein Classification

transposase family protein( domain architecture ID 1750059)

transposase family protein might bind to the end of a transposon and catalyze the movement of the transposon to another part of the genome by a cut and paste mechanism or a replicative transposition mechanism

Gene Ontology:  GO:0003677|GO:0006313
PubMed:  11774877

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
transpos_IS3 NF033516
IS3 family transposase;
12-365 1.15e-105

IS3 family transposase;


:

Pssm-ID: 468052 [Multi-domain]  Cd Length: 369  Bit Score: 315.66  E-value: 1.15e-105
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275611278  12 EFKQQIVN-IYLAGKPRVEIIREYELTASAFDKWVKQSKTSGSFKE----KDNLTPEQKELLELRKRNQQLEMENDILKQ 86
Cdd:NF033516    1 EFKLEAVReVLEGGKSVAEVARELGISPSTLYRWRKKYRGGGEAADagrlKELLTPEEEENRRLKRELAELRLENEILKK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275611278  87 AALIFGP--KRQVIDANKHLYPISAMCRILGLSRQSYYYQ-----SKPKKDESELEEVVAEEFILSRKAYGSRKIKKALS 159
Cdd:NF033516   81 ARKLLRPavKYALIDALRGEYSVRRACRVLGVSRSTYYYWrkrppSRRAPDDAELRARIREIFEESRGRYGYRRITALLR 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275611278 160 KRGIQISRRKISRIMKNRGLKSSYTVAYfKVHHSTCNEAKTT--NVLNRKFLRDNPLEAIVTDLTYVRVGKKWNYVCFIL 237
Cdd:NF033516  161 REGIRVNHKRVYRLMRELGLLARRRRKR-RPYTTDSGHVHPVapNLLNRQFTATRPNQVWVTDITYIRTAEGWLYLAVVL 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275611278 238 DLFNREILGYSCGEHKDAVLVKKAFSRI----RQPltEVEIFHTDRGKEFDNQAIDELLTTFDINRSLSHKGCPFDNAVA 313
Cdd:NF033516  240 DLFSREIVGWSVSTSMSAELVLDALEMAiewrGKP--EGLILHSDNGSQYTSKAYREWLKEHGITQSMSRPGNCWDNAVA 317

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1275611278 314 ESTYKSLKVEFVYQYTFETLQQLDLELFDYVNWWNHLRLHGTLGYETPVGYR 365
Cdd:NF033516  318 ESFFGTLKRECLYRRRFRTLEEARQAIEEYIEFYNHERPHSSLGYLTPAEFE 369
 
Name Accession Description Interval E-value
transpos_IS3 NF033516
IS3 family transposase;
12-365 1.15e-105

IS3 family transposase;


Pssm-ID: 468052 [Multi-domain]  Cd Length: 369  Bit Score: 315.66  E-value: 1.15e-105
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275611278  12 EFKQQIVN-IYLAGKPRVEIIREYELTASAFDKWVKQSKTSGSFKE----KDNLTPEQKELLELRKRNQQLEMENDILKQ 86
Cdd:NF033516    1 EFKLEAVReVLEGGKSVAEVARELGISPSTLYRWRKKYRGGGEAADagrlKELLTPEEEENRRLKRELAELRLENEILKK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275611278  87 AALIFGP--KRQVIDANKHLYPISAMCRILGLSRQSYYYQ-----SKPKKDESELEEVVAEEFILSRKAYGSRKIKKALS 159
Cdd:NF033516   81 ARKLLRPavKYALIDALRGEYSVRRACRVLGVSRSTYYYWrkrppSRRAPDDAELRARIREIFEESRGRYGYRRITALLR 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275611278 160 KRGIQISRRKISRIMKNRGLKSSYTVAYfKVHHSTCNEAKTT--NVLNRKFLRDNPLEAIVTDLTYVRVGKKWNYVCFIL 237
Cdd:NF033516  161 REGIRVNHKRVYRLMRELGLLARRRRKR-RPYTTDSGHVHPVapNLLNRQFTATRPNQVWVTDITYIRTAEGWLYLAVVL 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275611278 238 DLFNREILGYSCGEHKDAVLVKKAFSRI----RQPltEVEIFHTDRGKEFDNQAIDELLTTFDINRSLSHKGCPFDNAVA 313
Cdd:NF033516  240 DLFSREIVGWSVSTSMSAELVLDALEMAiewrGKP--EGLILHSDNGSQYTSKAYREWLKEHGITQSMSRPGNCWDNAVA 317

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1275611278 314 ESTYKSLKVEFVYQYTFETLQQLDLELFDYVNWWNHLRLHGTLGYETPVGYR 365
Cdd:NF033516  318 ESFFGTLKRECLYRRRFRTLEEARQAIEEYIEFYNHERPHSSLGYLTPAEFE 369
Tra5 COG2801
Transposase InsO and inactivated derivatives [Mobilome: prophages, transposons];
63-372 5.13e-68

Transposase InsO and inactivated derivatives [Mobilome: prophages, transposons];


Pssm-ID: 442053 [Multi-domain]  Cd Length: 309  Bit Score: 217.33  E-value: 5.13e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275611278  63 EQKELLELRKRNQQLEMEndILKQAALIFGPKRQVIDANKHLYPISAMCRILGLSRQSYYYQSK---PKKDESELEEVVA 139
Cdd:COG2801     1 ELAEEEELRKEEELLRRL--LLLLRLLLLRRRVLRRVSRRRRRLLRLLRRRRARSRRRRRLRRPrsyRADEDAELLERIK 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275611278 140 EEFiLSRKAYGSRKIKKALSKRGIQISRRKISRIMKNRGLKSSYTVAYFKVHHSTCNEAKTTNVLnrkFLRDNPLEAIVT 219
Cdd:COG2801    79 EIF-AESPRYGYRRITAELRREGIAVNRKRVRRLMRELGLQARRRRKKKYTTYSGHGGPIAPNLL---FTATAPNQVWVT 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275611278 220 DLTYVRVGKKWNYVCFILDLFNREILGYSCGEHKDAVLVKKAFSRI--RQPLTEVEIFHTDRGKEFDNQAIDELLTTFDI 297
Cdd:COG2801   155 DITYIPTAEGWLYLAAVIDLFSREIVGWSVSDSMDAELVVDALEMAieRRGPPKPLILHSDNGSQYTSKAYQELLKKLGI 234

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1275611278 298 NRSLSHKGCPFDNAVAESTYKSLKVEFVYQYTFETLQQLDLELFDYVNWWNHLRLHGTLGYETPVGYRNQRLAQR 372
Cdd:COG2801   235 TQSMSRPGNPQDNAFIESFFGTLKYELLYRRRFESLEEAREAIEEYIEFYNHERPHSSLGYLTPAEYEKQLAAAA 309
PHA02517 PHA02517
putative transposase OrfB; Reviewed
 114-371 2.51e-52

putative transposase OrfB; Reviewed


Pssm-ID: 222853 [Multi-domain]  Cd Length: 277  Bit Score: 175.44  E-value: 2.51e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275611278 114 LGLSRQSYYYQSKPKKDESE----------LEEVVAEEFILSRKAYGSRKIKKALSKRGIQISRRKISRIMKNRGLKSSy 183
Cdd:PHA02517    1 LGIAPSTYYRCQQQRHHPDKrraraqhddwLKSEILRVYDENHQVYGVRKVWRQLNREGIRVARCTVGRLMKELGLAGV- 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275611278 184 TVAYFKVHHSTCNEAKTTNVLNRKFLRDNPLEAIVTDLTYVRVGKKWNYVCFILDLFNREILGYSCGEHKDAVLVKKAFS 263
Cdd:PHA02517   80 LRGKKVRTTISRKAVAAPDRVNRQFVATRPNQLWVADFTYVSTWQGWVYVAFIIDVFARRIVGWRVSSSMDTDFVLDALE 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275611278 264 RIRQPLTEVE--IFHTDRGKEFDNQAIDELLTTFDINRSLSHKGCPFDNAVAESTYKSLKVEFVYQYTFETLQQLDLELF 341
Cdd:PHA02517  160 QALWARGRPGglIHHSDKGSQYVSLAYTQRLKEAGIRASTGSRGDSYDNAPAESINGLYKAEVIHRVSWKNREEVELATL 239

                         250       260       270
                  ....*....|....*....|....*....|
gi 1275611278 342 DYVNWWNHLRLHGTLGYETPVGYRNQRLAQ 371
Cdd:PHA02517  240 EWVAWYNNRRLHERLGYTPPAEAEKAYYAS 269
rve_2 pfam13333
Integrase core domain;
314-369 3.59e-19

Integrase core domain;


Pssm-ID: 372570 [Multi-domain]  Cd Length: 52  Bit Score: 80.38  E-value: 3.59e-19
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1275611278 314 ESTYKSLKVEFVYQYTFETLQQLDLELFDYVNWWNHLRLHGtlgyETPVGYRNQRL 369
Cdd:pfam13333   1 ESFFGSLKTEMVYGEHFKTLEELELAIFDYIEWYNNKRLKG----LSPVQYRNQSL 52
transpos_IS481 NF033577
IS481 family transposase; null
 106-362 4.81e-17

IS481 family transposase; null


Pssm-ID: 468094 [Multi-domain]  Cd Length: 283  Bit Score: 80.33  E-value: 4.81e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275611278 106 PISAMCRILGLSRQSYY-----YQ-----------SKPKKDESELEEVVaEEFIL---SRKAYGSRKIKKALSKRGIQIS 166
Cdd:NF033577   15 SVREAARRFGISRKTVYkwlkrYRaggeeglidrsRRPHRSPRRTSPET-EARILalrRELRLGPRRIAYELERQGPGVS 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275611278 167 RRKISRIMKNRGLkssytvayfkvhhSTCNEAKTTNVLNRKFLRDNPLEAIVTDLTYVR--VGKKWNYVCFILDLFNREI 244
Cdd:NF033577   94 RSTVHRILRRHGL-------------SRLRALDRKTGKVKRYERAHPGELWHIDIKKLGriPDVGRLYLHTAIDDHSRFA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275611278 245 LGYSCGEHKDAVLV---KKAFsrIRQPLTEVEIFhTDRGKEF--DNQAIDELLTTFDINRSLSHKGCPFDNAVAESTYKS 319
Cdd:NF033577  161 YAELYPDETAETAAdflRRAF--AEHGIPIRRVL-TDNGSEFrsRAHGFELALAELGIEHRRTRPYHPQTNGKVERFHRT 237

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 1275611278 320 LKVEFVYQYTFETLQQLDLELFDYVNWWNHLRLHGTLGYETPV 362
Cdd:NF033577  238 LKDEFAYARPYESLAELQAALDEWLHHYNHHRPHSALGGKTPA 280
 
Name Accession Description Interval E-value
transpos_IS3 NF033516
IS3 family transposase;
12-365 1.15e-105

IS3 family transposase;


Pssm-ID: 468052 [Multi-domain]  Cd Length: 369  Bit Score: 315.66  E-value: 1.15e-105
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275611278  12 EFKQQIVN-IYLAGKPRVEIIREYELTASAFDKWVKQSKTSGSFKE----KDNLTPEQKELLELRKRNQQLEMENDILKQ 86
Cdd:NF033516    1 EFKLEAVReVLEGGKSVAEVARELGISPSTLYRWRKKYRGGGEAADagrlKELLTPEEEENRRLKRELAELRLENEILKK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275611278  87 AALIFGP--KRQVIDANKHLYPISAMCRILGLSRQSYYYQ-----SKPKKDESELEEVVAEEFILSRKAYGSRKIKKALS 159
Cdd:NF033516   81 ARKLLRPavKYALIDALRGEYSVRRACRVLGVSRSTYYYWrkrppSRRAPDDAELRARIREIFEESRGRYGYRRITALLR 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275611278 160 KRGIQISRRKISRIMKNRGLKSSYTVAYfKVHHSTCNEAKTT--NVLNRKFLRDNPLEAIVTDLTYVRVGKKWNYVCFIL 237
Cdd:NF033516  161 REGIRVNHKRVYRLMRELGLLARRRRKR-RPYTTDSGHVHPVapNLLNRQFTATRPNQVWVTDITYIRTAEGWLYLAVVL 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275611278 238 DLFNREILGYSCGEHKDAVLVKKAFSRI----RQPltEVEIFHTDRGKEFDNQAIDELLTTFDINRSLSHKGCPFDNAVA 313
Cdd:NF033516  240 DLFSREIVGWSVSTSMSAELVLDALEMAiewrGKP--EGLILHSDNGSQYTSKAYREWLKEHGITQSMSRPGNCWDNAVA 317

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1275611278 314 ESTYKSLKVEFVYQYTFETLQQLDLELFDYVNWWNHLRLHGTLGYETPVGYR 365
Cdd:NF033516  318 ESFFGTLKRECLYRRRFRTLEEARQAIEEYIEFYNHERPHSSLGYLTPAEFE 369
Tra5 COG2801
Transposase InsO and inactivated derivatives [Mobilome: prophages, transposons];
63-372 5.13e-68

Transposase InsO and inactivated derivatives [Mobilome: prophages, transposons];


Pssm-ID: 442053 [Multi-domain]  Cd Length: 309  Bit Score: 217.33  E-value: 5.13e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275611278  63 EQKELLELRKRNQQLEMEndILKQAALIFGPKRQVIDANKHLYPISAMCRILGLSRQSYYYQSK---PKKDESELEEVVA 139
Cdd:COG2801     1 ELAEEEELRKEEELLRRL--LLLLRLLLLRRRVLRRVSRRRRRLLRLLRRRRARSRRRRRLRRPrsyRADEDAELLERIK 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275611278 140 EEFiLSRKAYGSRKIKKALSKRGIQISRRKISRIMKNRGLKSSYTVAYFKVHHSTCNEAKTTNVLnrkFLRDNPLEAIVT 219
Cdd:COG2801    79 EIF-AESPRYGYRRITAELRREGIAVNRKRVRRLMRELGLQARRRRKKKYTTYSGHGGPIAPNLL---FTATAPNQVWVT 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275611278 220 DLTYVRVGKKWNYVCFILDLFNREILGYSCGEHKDAVLVKKAFSRI--RQPLTEVEIFHTDRGKEFDNQAIDELLTTFDI 297
Cdd:COG2801   155 DITYIPTAEGWLYLAAVIDLFSREIVGWSVSDSMDAELVVDALEMAieRRGPPKPLILHSDNGSQYTSKAYQELLKKLGI 234

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1275611278 298 NRSLSHKGCPFDNAVAESTYKSLKVEFVYQYTFETLQQLDLELFDYVNWWNHLRLHGTLGYETPVGYRNQRLAQR 372
Cdd:COG2801   235 TQSMSRPGNPQDNAFIESFFGTLKYELLYRRRFESLEEAREAIEEYIEFYNHERPHSSLGYLTPAEYEKQLAAAA 309
PHA02517 PHA02517
putative transposase OrfB; Reviewed
 114-371 2.51e-52

putative transposase OrfB; Reviewed


Pssm-ID: 222853 [Multi-domain]  Cd Length: 277  Bit Score: 175.44  E-value: 2.51e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275611278 114 LGLSRQSYYYQSKPKKDESE----------LEEVVAEEFILSRKAYGSRKIKKALSKRGIQISRRKISRIMKNRGLKSSy 183
Cdd:PHA02517    1 LGIAPSTYYRCQQQRHHPDKrraraqhddwLKSEILRVYDENHQVYGVRKVWRQLNREGIRVARCTVGRLMKELGLAGV- 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275611278 184 TVAYFKVHHSTCNEAKTTNVLNRKFLRDNPLEAIVTDLTYVRVGKKWNYVCFILDLFNREILGYSCGEHKDAVLVKKAFS 263
Cdd:PHA02517   80 LRGKKVRTTISRKAVAAPDRVNRQFVATRPNQLWVADFTYVSTWQGWVYVAFIIDVFARRIVGWRVSSSMDTDFVLDALE 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275611278 264 RIRQPLTEVE--IFHTDRGKEFDNQAIDELLTTFDINRSLSHKGCPFDNAVAESTYKSLKVEFVYQYTFETLQQLDLELF 341
Cdd:PHA02517  160 QALWARGRPGglIHHSDKGSQYVSLAYTQRLKEAGIRASTGSRGDSYDNAPAESINGLYKAEVIHRVSWKNREEVELATL 239

                         250       260       270
                  ....*....|....*....|....*....|
gi 1275611278 342 DYVNWWNHLRLHGTLGYETPVGYRNQRLAQ 371
Cdd:PHA02517  240 EWVAWYNNRRLHERLGYTPPAEAEKAYYAS 269
InsE COG2963
Transposase InsE and inactivated derivatives [Mobilome: prophages, transposons];
1-91 1.91e-21

Transposase InsE and inactivated derivatives [Mobilome: prophages, transposons];


Pssm-ID: 442203 [Multi-domain]  Cd Length: 93  Bit Score: 87.67  E-value: 1.91e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275611278   1 MSKRtRRTFSQEFKQQIVNIYLA-GKPRVEIIREYELTASAFDKWVKQSKTSG--SFKEKDNLTPEQKELLELRKRNQQL 77
Cdd:COG2963     1 MSKK-RRRYSPEFKAEAVRLVLEgGASVAEVARELGISPSTLYRWVRQYREGGlgGFPGDGRTTPEQAEIRRLRKELRRL 79

                          90
                  ....*....|....
gi 1275611278  78 EMENDILKQAALIF 91
Cdd:COG2963    80 EMENDILKKAAALL 93
rve_2 pfam13333
Integrase core domain;
314-369 3.59e-19

Integrase core domain;


Pssm-ID: 372570 [Multi-domain]  Cd Length: 52  Bit Score: 80.38  E-value: 3.59e-19
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1275611278 314 ESTYKSLKVEFVYQYTFETLQQLDLELFDYVNWWNHLRLHGtlgyETPVGYRNQRL 369
Cdd:pfam13333   1 ESFFGSLKTEMVYGEHFKTLEELELAIFDYIEWYNNKRLKG----LSPVQYRNQSL 52
transpos_IS481 NF033577
IS481 family transposase; null
 106-362 4.81e-17

IS481 family transposase; null


Pssm-ID: 468094 [Multi-domain]  Cd Length: 283  Bit Score: 80.33  E-value: 4.81e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275611278 106 PISAMCRILGLSRQSYY-----YQ-----------SKPKKDESELEEVVaEEFIL---SRKAYGSRKIKKALSKRGIQIS 166
Cdd:NF033577   15 SVREAARRFGISRKTVYkwlkrYRaggeeglidrsRRPHRSPRRTSPET-EARILalrRELRLGPRRIAYELERQGPGVS 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275611278 167 RRKISRIMKNRGLkssytvayfkvhhSTCNEAKTTNVLNRKFLRDNPLEAIVTDLTYVR--VGKKWNYVCFILDLFNREI 244
Cdd:NF033577   94 RSTVHRILRRHGL-------------SRLRALDRKTGKVKRYERAHPGELWHIDIKKLGriPDVGRLYLHTAIDDHSRFA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275611278 245 LGYSCGEHKDAVLV---KKAFsrIRQPLTEVEIFhTDRGKEF--DNQAIDELLTTFDINRSLSHKGCPFDNAVAESTYKS 319
Cdd:NF033577  161 YAELYPDETAETAAdflRRAF--AEHGIPIRRVL-TDNGSEFrsRAHGFELALAELGIEHRRTRPYHPQTNGKVERFHRT 237

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 1275611278 320 LKVEFVYQYTFETLQQLDLELFDYVNWWNHLRLHGTLGYETPV 362
Cdd:NF033577  238 LKDEFAYARPYESLAELQAALDEWLHHYNHHRPHSALGGKTPA 280
rve pfam00665
Integrase core domain; Integrase mediates integration of a DNA copy of the viral genome into ...
 213-307 9.46e-17

Integrase core domain; Integrase mediates integration of a DNA copy of the viral genome into the host chromosome. Integrase is composed of three domains. The amino-terminal domain is a zinc binding domain pfam02022. This domain is the central catalytic domain. The carboxyl terminal domain that is a non-specific DNA binding domain pfam00552. The catalytic domain acts as an endonuclease when two nucleotides are removed from the 3' ends of the blunt-ended viral DNA made by reverse transcription. This domain also catalyzes the DNA strand transfer reaction of the 3' ends of the viral DNA to the 5' ends of the integration site.


Pssm-ID: 459897 [Multi-domain]  Cd Length: 98  Bit Score: 75.04  E-value: 9.46e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275611278 213 PLEAIVTDLTYVRV--GKKWNYVCFILDLFNREILGYSCGEHKDAVLVKKAFSR-IRQPLTEVEIFHTDRGKEFDNQAID 289
Cdd:pfam00665   1 PNQLWQGDFTYIRIpgGGGKLYLLVIVDDFSREILAWALSSEMDAELVLDALERaIAFRGGVPLIIHSDNGSEYTSKAFR 80

                          90
                  ....*....|....*...
gi 1275611278 290 ELLTTFDINRSLSHKGCP 307
Cdd:pfam00665  81 EFLKDLGIKPSFSRPGNP 98
rve_3 pfam13683
Integrase core domain;
296-361 2.71e-10

Integrase core domain;


Pssm-ID: 433402 [Multi-domain]  Cd Length: 67  Bit Score: 55.69  E-value: 2.71e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1275611278 296 DINRSLSHKGCPFDNAVAESTYKSLKVEFVYQYTFETLQQLDLELFDYVNWWNHLRLHGTLGYETP 361
Cdd:pfam13683   2 GIEISYIAPGKPMQNGLVESFNGTLRDECLNEHLFSSLAEARALLAAWREDYNTERPHSSLGYRTP 67
HTH_21 pfam13276
HTH-like domain; This domain contains a predicted helix-turn-helix suggesting a DNA-binding ...
 129-187 3.24e-08

HTH-like domain; This domain contains a predicted helix-turn-helix suggesting a DNA-binding function.


Pssm-ID: 463824 [Multi-domain]  Cd Length: 60  Bit Score: 49.87  E-value: 3.24e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275611278 129 KDESELEEVVAEEFILSRKAYGSRKIKKALSKRG-IQISRRKISRIMKNRGLKSSYTVAY 187
Cdd:pfam13276   1 ELEDELLEAIREIFEESRGTYGYRRITAELRREGgIRVNRKRVARLMRELGLRARRRRKR 60
HTH_Tnp_1 pfam01527
Transposase; Transposase proteins are necessary for efficient DNA transposition. This family ...
 3-74 5.51e-08

Transposase; Transposase proteins are necessary for efficient DNA transposition. This family consists of various E. coli insertion elements and other bacterial transposases some of which are members of the IS3 family.


Pssm-ID: 426308 [Multi-domain]  Cd Length: 75  Bit Score: 49.66  E-value: 5.51e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1275611278   3 KRTRRTFSQEFKQQIVNIYLAGKPRV-EIIREYELTASAFDKWVKQ-SKTSGSFKEKDNLTPEQKELLELRKRN 74
Cdd:pfam01527   1 MKKRRRFSEEFKLRAVKEVLEPGRTVkEVARRHGVSPNTLYQWRRQyEGGMGASPARPRLTALEEENRRLKREL 74
Rve COG3316
Transposase (or an inactivated derivative), DDE domain [Mobilome: prophages, transposons];
165-362 6.16e-04

Transposase (or an inactivated derivative), DDE domain [Mobilome: prophages, transposons];


Pssm-ID: 442545 [Multi-domain]  Cd Length: 235  Bit Score: 41.04  E-value: 6.16e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275611278 165 ISRRKISRIMKNRGLKSSYTVAYFKVHhstcneaKTTNVLNRKFLRDNPLEA--IVTDLTYVRVGKKWNYVCFILDLfNR 242
Cdd:COG3316    26 LSLRDVEEMLAERGVDVSHSTIYRWVQ-------KFAPLIAKRLRRRRPPLSdsWHVDETYIKIKGKWHYLYRAVDA-EG 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275611278 243 EILGYSCGEHKDAVLVKKAFSR-IRQPLTEVEIFHTDRGKEFDnQAIDELLTTFDINrsLSHKGCPFDNAVAESTYKSLK 321
Cdd:COG3316    98 RILDFLLSPRRDTKAAKRFLRKaLKKYGLKPRVIVTDKLPSYG-AALRELKPEGGLG--VEHRQVKGLNNRIERDHRTLK 174

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1275611278 322 -VEFVYQY--TFETLQQLdLELFdyVNWWNHLRLHGTLGYETPV 362
Cdd:COG3316   175 rRERPMRGfkSFRTAQRF-LSGF--EAYYNFRRPHRSLNGATPA 215
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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