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Conserved domains on  [gi|1279652156|ref|WP_100208218|]
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MULTISPECIES: peptide chain release factor 2 [Staphylococcus]

Protein Classification

PCRF domain-containing protein( domain architecture ID 1750053)

peptide chain release factor (PCRF) domain-containing protein similar to Homo sapiens mitochondrial peptide chain release factor 1 (MTRF1), MTRF1-like and 28S mitochondrial ribosomal protein S35 (MRPS35)

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PCRF super family cl40670
This domain is found in peptide chain release factors;
2-363 0e+00

This domain is found in peptide chain release factors;


The actual alignment was detected with superfamily member TIGR00020:

Pssm-ID: 477417 [Multi-domain]  Cd Length: 364  Bit Score: 526.27  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279652156   2 ELSEIKRNIDEYRNNLAQIRGSLDLENKETNIQEYEEMMTEPDFWDDQNKAQEVIDKNNALKSVVNGYHELEEEVEDMTA 81
Cdd:TIGR00020   1 EINEVNNRIEDLTSRLDTVRGSLDPEKKKARLEELEKEMEDPNFWNDQERAQAVIKERSSLEAVLDTLEELKNSLEDLSE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279652156  82 TWELLQEELDDDVKSDLEQNVLDFKEKVDQFELQLLLDGPHDANNAILELHPGAGGTESQDWASMLLRMYQRYGEQQGFK 161
Cdd:TIGR00020  81 LLELAVEEDDEETFNELDAELKALEKKLAELELRTMLSGEYDANNAYLTIQAGAGGTEAQDWASMLYRMYLRWAERRGFK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279652156 162 VETVDYLPGDEAGVKSVTLLIKGHNAYGYLKAEKGVHRLVRISPFDSSGRRHTSFASCDVIPEFnNDEIEIEINPDDITV 241
Cdd:TIGR00020 161 VEIIDYSEGEEAGIKSVTILIKGPYAYGYLKSEQGVHRLVRISPFDANGRRHTSFASVFVMPEV-DDDIDIEIKPEDLRI 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279652156 242 DTFRASGAGGQHINKTESAIRITHHPTGIVVNNQNERSQIKNREAAMKMLKAKLYQLKLEEQEREMAEIRGEQKEIGWGS 321
Cdd:TIGR00020 240 DTYRASGAGGQHVNKTDSAVRITHIPTGIVVQCQNDRSQHKNKDSAMKVLKAKLYELEMEKEQAEKDAKEGEKSEIGWGS 319

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|..
gi 1279652156 322 QIRSYVFHPYSMVKDHRTNEETGKVDAVMDGEIGPFIESYLR 363
Cdd:TIGR00020 320 QIRSYVLHPYSMVKDLRTGYETGNVQAVLDGDIDQFIEAYLK 361
 
Name Accession Description Interval E-value
prfB TIGR00020
peptide chain release factor 2; In many but not all taxa, there is a conserved real ...
 2-363 0e+00

peptide chain release factor 2; In many but not all taxa, there is a conserved real translational frameshift at a TGA codon. RF-2 helps terminate translation at TGA codons and can therefore regulate its own production by readthrough when RF-2 is insufficient. There is a Pfam model called "RF-1" for the superfamily of RF-1, RF-2, mitochondrial, RF-H, etc. [Protein synthesis, Translation factors]


Pssm-ID: 272858 [Multi-domain]  Cd Length: 364  Bit Score: 526.27  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279652156   2 ELSEIKRNIDEYRNNLAQIRGSLDLENKETNIQEYEEMMTEPDFWDDQNKAQEVIDKNNALKSVVNGYHELEEEVEDMTA 81
Cdd:TIGR00020   1 EINEVNNRIEDLTSRLDTVRGSLDPEKKKARLEELEKEMEDPNFWNDQERAQAVIKERSSLEAVLDTLEELKNSLEDLSE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279652156  82 TWELLQEELDDDVKSDLEQNVLDFKEKVDQFELQLLLDGPHDANNAILELHPGAGGTESQDWASMLLRMYQRYGEQQGFK 161
Cdd:TIGR00020  81 LLELAVEEDDEETFNELDAELKALEKKLAELELRTMLSGEYDANNAYLTIQAGAGGTEAQDWASMLYRMYLRWAERRGFK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279652156 162 VETVDYLPGDEAGVKSVTLLIKGHNAYGYLKAEKGVHRLVRISPFDSSGRRHTSFASCDVIPEFnNDEIEIEINPDDITV 241
Cdd:TIGR00020 161 VEIIDYSEGEEAGIKSVTILIKGPYAYGYLKSEQGVHRLVRISPFDANGRRHTSFASVFVMPEV-DDDIDIEIKPEDLRI 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279652156 242 DTFRASGAGGQHINKTESAIRITHHPTGIVVNNQNERSQIKNREAAMKMLKAKLYQLKLEEQEREMAEIRGEQKEIGWGS 321
Cdd:TIGR00020 240 DTYRASGAGGQHVNKTDSAVRITHIPTGIVVQCQNDRSQHKNKDSAMKVLKAKLYELEMEKEQAEKDAKEGEKSEIGWGS 319

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|..
gi 1279652156 322 QIRSYVFHPYSMVKDHRTNEETGKVDAVMDGEIGPFIESYLR 363
Cdd:TIGR00020 320 QIRSYVLHPYSMVKDLRTGYETGNVQAVLDGDIDQFIEAYLK 361
PRK06746 PRK06746
peptide chain release factor 2; Provisional
 40-363 8.30e-165

peptide chain release factor 2; Provisional


Pssm-ID: 75726 [Multi-domain]  Cd Length: 326  Bit Score: 463.82  E-value: 8.30e-165
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279652156  40 MTEPDFWDDQNKAQEVIDKNNALKSVVNGYHELEEEVEDMTATWELLQEELDDDVKSDLEQNVLDFKEKVDQFELQLLLD 119
Cdd:PRK06746    1 MMGAGFWDDQQGAQAVINEANALKDMVGKFRQLDETFENLEITHELLKEEYDEDLHEELESEVKGLIQEMNEYELQLLLS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279652156 120 GPHDANNAILELHPGAGGTESQDWASMLLRMYQRYGEQQGFKVETVDYLPGDEAGVKSVTLLIKGHNAYGYLKAEKGVHR 199
Cdd:PRK06746   81 DPYDKNNAILELHPGAGGTESQDWGSMLLRMYTRWAEKRGFKVETVDYLPGDEAGIKSVTLLIKGHNAYGYLKAEKGVHR 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279652156 200 LVRISPFDSSGRRHTSFASCDVIPEFnNDEIEIEINPDDITVDTFRASGAGGQHINKTESAIRITHHPTGIVVNNQNERS 279
Cdd:PRK06746  161 LVRISPFDSSGRRHTSFVSCEVVPEF-NDEVEIEVRTEDLKIDTYRASGAGGQHVNTTDSAVRITHTPTNTVVTCQSERS 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279652156 280 QIKNREAAMKMLKAKLYQLKLEEQEREMAEIRGEQKEIGWGSQIRSYVFHPYSMVKDHRTNEETGKVDAVMDGEIGPFIE 359
Cdd:PRK06746  240 QIKNREHAMKMLKAKLYQKKLEEQQAELDEIRGEQKEIGWGSQIRSYVFHPYSLVKDHRTNTEVGNVQAVMDGEIDPFID 319


                  ....
gi 1279652156 360 SYLR 363
Cdd:PRK06746  320 AYLR 323
PrfA COG0216
Protein chain release factor RF1 [Translation, ribosomal structure and biogenesis]; Protein ...
 26-360 5.85e-111

Protein chain release factor RF1 [Translation, ribosomal structure and biogenesis]; Protein chain release factor RF1 is part of the Pathway/BioSystem: Translation factors


Pssm-ID: 439986 [Multi-domain]  Cd Length: 356  Bit Score: 328.11  E-value: 5.85e-111
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279652156  26 LENKETNIQEYEEMMTEPDFWDDQNKAQEVIDKNNALKSVVNGYHELEEEVEDMTATWELLQEELDDDVKSDLEQNVLDF 105
Cdd:COG0216     6 LEALEERYEELEALLSDPEVISDQKRFRKLSKEYAELEPIVEAYREYKKLLEDIEEAKELLEEESDPEMREMAKEELEEL 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279652156 106 KEKVDQFE--LQLLL---DgPHDANNAILELHPGAGGTESQDWASMLLRMYQRYGEQQGFKVETVDYLPGDEAGVKSVTL 180
Cdd:COG0216    86 EARLEELEeeLKILLlpkD-PNDDKNVILEIRAGTGGDEAALFAGDLFRMYSRYAERKGWKVEILSASEGELGGYKEVIF 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279652156 181 LIKGHNAYGYLKAEKGVHRLVRISPFDSSGRRHTSFASCDVIPEFnnDEIEIEINPDDITVDTFRASGAGGQHINKTESA 260
Cdd:COG0216   165 RISGEGVYSRLKFESGVHRVQRVPETESQGRIHTSAATVAVLPEA--EEVDVEINPKDLRIDTFRSSGAGGQHVNTTDSA 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279652156 261 IRITHHPTGIVVNNQNERSQIKNREAAMKMLKAKLYQLKLEEQEREMAEIRGEQkeIGWG--SQ-IRSYVFhPYSMVKDH 337
Cdd:COG0216   243 VRITHLPTGIVVECQDERSQHKNKAKAMKVLRARLYEAEQQKQQAEIAAERKSQ--VGSGdrSErIRTYNF-PQGRVTDH 319

                         330       340
                  ....*....|....*....|...
gi 1279652156 338 RTNEETGKVDAVMDGEIGPFIES 360
Cdd:COG0216   320 RINLTLYKLDEVMEGDLDELIDA 342
PCRF pfam03462
PCRF domain; This domain is found in peptide chain release factors.
 33-218 2.57e-81

PCRF domain; This domain is found in peptide chain release factors.


Pssm-ID: 460929 [Multi-domain]  Cd Length: 192  Bit Score: 246.53  E-value: 2.57e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279652156  33 IQEYEEMMTEPDFWDDQNKAQEVIDKNNALKSVVNGYHELEEEVEDMTATWELLQE-ELDDDVKSDLEQNVLDFKEKVDQ 111
Cdd:pfam03462   5 YEELEALLSDPDVWDDQKRAQKLSKEYSELEPIVEAYREYKQALEDLEEAKELLEDpELAELAEEELEELEKRLEELEEE 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279652156 112 FELQLLLDGPHDANNAILELHPGAGGTESQDWASMLLRMYQRYGEQQGFKVETVDYLPGDEAGVKSVTLLIKGHNAYGYL 191
Cdd:pfam03462  85 LKLLLLPKDPNDDKNAILEIRAGAGGDEAALFAGDLFRMYTRYAERKGWKVEVLDYSETEAGGIKEATFEISGEGAYGRL 164

                         170       180
                  ....*....|....*....|....*..
gi 1279652156 192 KAEKGVHRLVRISPFDSSGRRHTSFAS 218
Cdd:pfam03462 165 KFESGVHRVQRVPPTESQGRIHTSFAT 191
PCRF smart00937
This domain is found in peptide chain release factors;
84-194 1.15e-47

This domain is found in peptide chain release factors;


Pssm-ID: 214923 [Multi-domain]  Cd Length: 116  Bit Score: 157.24  E-value: 1.15e-47
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279652156   84 ELLQEELDDD----VKSDLEQNVLDFKEKVDQFELQLLLDG-PHDANNAILELHPGAGGTESQDWASMLLRMYQRYGEQQ 158
Cdd:smart00937   1 ELLEEEEDDEmrelAEEELEELEAELEEELEELLKLLLLPKdPNDDKNAILEIRAGAGGDEAALFAGDLLRMYLRYAERK 80

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 1279652156  159 GFKVETVDYLPGDEAGVKSVTLLIKGHNAYGYLKAE 194
Cdd:smart00937  81 GWKVEVLDESEGELGGIKEATLKISGEGAYGKLKFE 116
 
Name Accession Description Interval E-value
prfB TIGR00020
peptide chain release factor 2; In many but not all taxa, there is a conserved real ...
 2-363 0e+00

peptide chain release factor 2; In many but not all taxa, there is a conserved real translational frameshift at a TGA codon. RF-2 helps terminate translation at TGA codons and can therefore regulate its own production by readthrough when RF-2 is insufficient. There is a Pfam model called "RF-1" for the superfamily of RF-1, RF-2, mitochondrial, RF-H, etc. [Protein synthesis, Translation factors]


Pssm-ID: 272858 [Multi-domain]  Cd Length: 364  Bit Score: 526.27  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279652156   2 ELSEIKRNIDEYRNNLAQIRGSLDLENKETNIQEYEEMMTEPDFWDDQNKAQEVIDKNNALKSVVNGYHELEEEVEDMTA 81
Cdd:TIGR00020   1 EINEVNNRIEDLTSRLDTVRGSLDPEKKKARLEELEKEMEDPNFWNDQERAQAVIKERSSLEAVLDTLEELKNSLEDLSE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279652156  82 TWELLQEELDDDVKSDLEQNVLDFKEKVDQFELQLLLDGPHDANNAILELHPGAGGTESQDWASMLLRMYQRYGEQQGFK 161
Cdd:TIGR00020  81 LLELAVEEDDEETFNELDAELKALEKKLAELELRTMLSGEYDANNAYLTIQAGAGGTEAQDWASMLYRMYLRWAERRGFK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279652156 162 VETVDYLPGDEAGVKSVTLLIKGHNAYGYLKAEKGVHRLVRISPFDSSGRRHTSFASCDVIPEFnNDEIEIEINPDDITV 241
Cdd:TIGR00020 161 VEIIDYSEGEEAGIKSVTILIKGPYAYGYLKSEQGVHRLVRISPFDANGRRHTSFASVFVMPEV-DDDIDIEIKPEDLRI 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279652156 242 DTFRASGAGGQHINKTESAIRITHHPTGIVVNNQNERSQIKNREAAMKMLKAKLYQLKLEEQEREMAEIRGEQKEIGWGS 321
Cdd:TIGR00020 240 DTYRASGAGGQHVNKTDSAVRITHIPTGIVVQCQNDRSQHKNKDSAMKVLKAKLYELEMEKEQAEKDAKEGEKSEIGWGS 319

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|..
gi 1279652156 322 QIRSYVFHPYSMVKDHRTNEETGKVDAVMDGEIGPFIESYLR 363
Cdd:TIGR00020 320 QIRSYVLHPYSMVKDLRTGYETGNVQAVLDGDIDQFIEAYLK 361
PRK06746 PRK06746
peptide chain release factor 2; Provisional
 40-363 8.30e-165

peptide chain release factor 2; Provisional


Pssm-ID: 75726 [Multi-domain]  Cd Length: 326  Bit Score: 463.82  E-value: 8.30e-165
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279652156  40 MTEPDFWDDQNKAQEVIDKNNALKSVVNGYHELEEEVEDMTATWELLQEELDDDVKSDLEQNVLDFKEKVDQFELQLLLD 119
Cdd:PRK06746    1 MMGAGFWDDQQGAQAVINEANALKDMVGKFRQLDETFENLEITHELLKEEYDEDLHEELESEVKGLIQEMNEYELQLLLS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279652156 120 GPHDANNAILELHPGAGGTESQDWASMLLRMYQRYGEQQGFKVETVDYLPGDEAGVKSVTLLIKGHNAYGYLKAEKGVHR 199
Cdd:PRK06746   81 DPYDKNNAILELHPGAGGTESQDWGSMLLRMYTRWAEKRGFKVETVDYLPGDEAGIKSVTLLIKGHNAYGYLKAEKGVHR 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279652156 200 LVRISPFDSSGRRHTSFASCDVIPEFnNDEIEIEINPDDITVDTFRASGAGGQHINKTESAIRITHHPTGIVVNNQNERS 279
Cdd:PRK06746  161 LVRISPFDSSGRRHTSFVSCEVVPEF-NDEVEIEVRTEDLKIDTYRASGAGGQHVNTTDSAVRITHTPTNTVVTCQSERS 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279652156 280 QIKNREAAMKMLKAKLYQLKLEEQEREMAEIRGEQKEIGWGSQIRSYVFHPYSMVKDHRTNEETGKVDAVMDGEIGPFIE 359
Cdd:PRK06746  240 QIKNREHAMKMLKAKLYQKKLEEQQAELDEIRGEQKEIGWGSQIRSYVFHPYSLVKDHRTNTEVGNVQAVMDGEIDPFID 319


                  ....
gi 1279652156 360 SYLR 363
Cdd:PRK06746  320 AYLR 323
PRK05589 PRK05589
peptide chain release factor 2; Provisional
 40-363 1.48e-153

peptide chain release factor 2; Provisional


Pssm-ID: 235520 [Multi-domain]  Cd Length: 325  Bit Score: 435.39  E-value: 1.48e-153
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279652156  40 MTEPDFWDDQNKAQEVIDKNNALKSVVNGYHELEEEVEDMTATWELLQEElDDDVKSDLEQNVLDFKEKVDQFELQLLLD 119
Cdd:PRK05589    1 MQEPNFWNDIKEAQEITSEEKYLKDKLDKYNHLRNRIEDIEVLCEMMSEE-DDEMKKEIISEVKNIKEEIDRFKIETLLS 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279652156 120 GPHDANNAILELHPGAGGTESQDWASMLLRMYQRYGEQQGFKVETVDYLPGDEAGVKSVTLLIKGHNAYGYLKAEKGVHR 199
Cdd:PRK05589   80 GEYDRNNAILTLHSGVGGTDAQDWTEMLLRMYTRWAEKKGYKVEIIDLLEGDEAGIKSVTLKITGEFAYGYLKAEKGIHR 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279652156 200 LVRISPFDSSGRRHTSFASCDVIPEFNNDEiEIEINPDDITVDTFRASGAGGQHINKTESAIRITHHPTGIVVNNQNERS 279
Cdd:PRK05589  160 LVRISPFNANGKRQTSFASVEVLPELTDDQ-DIEIRSEDLKIDTYRAGGAGGQHVNKTESAVRITHIPTGIVVQCQNERS 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279652156 280 QIKNREAAMKMLKAKLYQLKLEEQEREMAEIRGEQKEIGWGSQIRSYVFHPYSMVKDHRTNEETGKVDAVMDGEIGPFIE 359
Cdd:PRK05589  239 QHSNKETAMKMLKSKLVELKERAHKEKIEDLTGELKDMGWGSQIRSYVFHPYNLVKDHRTGVETSNVDSVMDGDIDNFIT 318


                  ....
gi 1279652156 360 SYLR 363
Cdd:PRK05589  319 QYLK 322
PRK07342 PRK07342
peptide chain release factor 2; Provisional
 42-362 2.62e-126

peptide chain release factor 2; Provisional


Pssm-ID: 235997 [Multi-domain]  Cd Length: 339  Bit Score: 366.51  E-value: 2.62e-126
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279652156  42 EPDFWDDQNKAQEVIDKNNALKSVVNGYHELEEEVEDMTATWELLQEELDDDVKSDLEQNVLDFKEKVDQFELQLLLDGP 121
Cdd:PRK07342    5 DPSLWNDAQEAQKLMRERQQLDDSINGINHLEQTLNDNIELIAMGEEEGDKSIVEDAEKTIRDLKDEIDRRQIDALLSGE 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279652156 122 HDANNAILELHPGAGGTESQDWASMLLRMYQRYGEQQGFKVETVDYLPGDEAGVKSVTLLIKGHNAYGYLKAEKGVHRLV 201
Cdd:PRK07342   85 ADANDTYLEVHAGAGGTESQDWASMLLRMYTRWAERQGRKVEVLEVHDGEEAGIKSATILVKGHNAYGWLKTESGVHRLV 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279652156 202 RISPFDSSGRRHTSFASCDVIPEFnNDEIEIEINPDDITVDTFRASGAGGQHINKTESAIRITHHPTGIVVNNQNERSQI 281
Cdd:PRK07342  165 RISPYDSNARRHTSFASIWVYPVI-DDNIEVDVNESDVRIDTYRSSGAGGQHVNTTDSAVRITHIPTGIVVQCQQERSQH 243

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279652156 282 KNREAAMKMLKAKLYQLKLEEQEREMAEIRGEQKEIGWGSQIRSYVFHPYSMVKDHRTNEETGKVDAVMDGEIGPFIESY 361
Cdd:PRK07342  244 KNRAKAWSMLRARLYEEELKKREEATNAAAASKTDIGWGHQIRSYVLQPYQLVKDLRTGVESTNPQDVLDGDLNEFMEAA 323


                  .
gi 1279652156 362 L 362
Cdd:PRK07342  324 L 324
prfA PRK00591
peptide chain release factor 1; Validated
 34-360 5.94e-113

peptide chain release factor 1; Validated


Pssm-ID: 234801 [Multi-domain]  Cd Length: 359  Bit Score: 333.20  E-value: 5.94e-113
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279652156  34 QEYEEMMTEPDFWDDQNKAQEVIDKNNALKSVVNGYHELEEEVEDMTATWELLQEELDDDVKSDLEQNVLDFKEKVDQFE 113
Cdd:PRK00591   16 EELEALLSDPEVISDQKRFRKLSKEYAELEPIVEAYREYKQAQEDLEEAKEMLEEESDPEMREMAKEELKELEERLEELE 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279652156 114 --LQLLL---DgPHDANNAILELHPGAGGTESQDWASMLLRMYQRYGEQQGFKVETVDYLPGDEAGVKSVTLLIKGHNAY 188
Cdd:PRK00591   96 eeLKILLlpkD-PNDDKNVILEIRAGTGGDEAALFAGDLFRMYSRYAERQGWKVEILSASEGELGGYKEVIAEISGDGVY 174

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279652156 189 GYLKAEKGVHRLVRISPFDSSGRRHTSFASCDVIPEFnnDEIEIEINPDDITVDTFRASGAGGQHINKTESAIRITHHPT 268
Cdd:PRK00591  175 SKLKFESGVHRVQRVPATESQGRIHTSAATVAVLPEA--EEVEVEINPKDLRIDTFRSSGAGGQHVNTTDSAVRITHLPT 252

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279652156 269 GIVVNNQNERSQIKNREAAMKMLKAKLYQLKLEEQEREMAEIRGEQkeIGWGS---QIRSYVFhPYSMVKDHRTNEETGK 345
Cdd:PRK00591  253 GIVVECQDERSQHKNKAKAMKVLRARLYDAERQKAQAEEAATRKSQ--VGSGDrseRIRTYNF-PQGRVTDHRINLTLYK 329

                         330
                  ....*....|....*
gi 1279652156 346 VDAVMDGEIGPFIES 360
Cdd:PRK00591  330 LDEVMEGDLDELIDA 344
PrfA COG0216
Protein chain release factor RF1 [Translation, ribosomal structure and biogenesis]; Protein ...
 26-360 5.85e-111

Protein chain release factor RF1 [Translation, ribosomal structure and biogenesis]; Protein chain release factor RF1 is part of the Pathway/BioSystem: Translation factors


Pssm-ID: 439986 [Multi-domain]  Cd Length: 356  Bit Score: 328.11  E-value: 5.85e-111
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279652156  26 LENKETNIQEYEEMMTEPDFWDDQNKAQEVIDKNNALKSVVNGYHELEEEVEDMTATWELLQEELDDDVKSDLEQNVLDF 105
Cdd:COG0216     6 LEALEERYEELEALLSDPEVISDQKRFRKLSKEYAELEPIVEAYREYKKLLEDIEEAKELLEEESDPEMREMAKEELEEL 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279652156 106 KEKVDQFE--LQLLL---DgPHDANNAILELHPGAGGTESQDWASMLLRMYQRYGEQQGFKVETVDYLPGDEAGVKSVTL 180
Cdd:COG0216    86 EARLEELEeeLKILLlpkD-PNDDKNVILEIRAGTGGDEAALFAGDLFRMYSRYAERKGWKVEILSASEGELGGYKEVIF 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279652156 181 LIKGHNAYGYLKAEKGVHRLVRISPFDSSGRRHTSFASCDVIPEFnnDEIEIEINPDDITVDTFRASGAGGQHINKTESA 260
Cdd:COG0216   165 RISGEGVYSRLKFESGVHRVQRVPETESQGRIHTSAATVAVLPEA--EEVDVEINPKDLRIDTFRSSGAGGQHVNTTDSA 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279652156 261 IRITHHPTGIVVNNQNERSQIKNREAAMKMLKAKLYQLKLEEQEREMAEIRGEQkeIGWG--SQ-IRSYVFhPYSMVKDH 337
Cdd:COG0216   243 VRITHLPTGIVVECQDERSQHKNKAKAMKVLRARLYEAEQQKQQAEIAAERKSQ--VGSGdrSErIRTYNF-PQGRVTDH 319

                         330       340
                  ....*....|....*....|...
gi 1279652156 338 RTNEETGKVDAVMDGEIGPFIES 360
Cdd:COG0216   320 RINLTLYKLDEVMEGDLDELIDA 342
PRK08787 PRK08787
peptide chain release factor 2; Provisional
 62-363 1.00e-103

peptide chain release factor 2; Provisional


Pssm-ID: 136970 [Multi-domain]  Cd Length: 313  Bit Score: 308.13  E-value: 1.00e-103
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279652156  62 LKSVVNGYHELEEEVEDMTATWELLQEELDDDVKSDLEQNVLDFKEKVDQFELQLLLDGPHDANNAILELHPGAGGTESQ 141
Cdd:PRK08787    2 LEKTVIGIADVLSGLADAGELLDLAESEQDEDTALAVIADLDKYQAHVEKLEFQRMFSGQMDGANAFVDIQAGAGGTEAQ 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279652156 142 DWASMLLRMYQRYGEQQGFKVETVDYLPGDEAGVKSVTLLIKGHNAYGYLKAEKGVHRLVRISPFDSSGRRHTSFASCDV 221
Cdd:PRK08787   82 DWAEILLRMYLRWAESRGWKTELMEVSGGEVAGIKSATVRIEGEYAYGWLKTEIGVHRLVRKSPFDSDNRRHTSFTSVFV 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279652156 222 IPEFnNDEIEIEINPDDITVDTFRASGAGGQHINKTESAIRITHHPTGIVVNNQNERSQIKNREAAMKMLKAKLYQLKLE 301
Cdd:PRK08787  162 SPEV-DDNIEIDINPADLRTDVYRSSGAGGQHVNKTESAVRITHIPTNTVVACQTGRSQHQNRDNAMKMLAAKLYELEVQ 240

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1279652156 302 EQEREMAEIRGEQKEIGWGSQIRSYVFHPySMVKDHRTNEETGKVDAVMDGEIGPFIESYLR 363
Cdd:PRK08787  241 KRNAEKDALEATKSDIGWGSQIRNYVLDQ-SRIKDLRTGIERSDTQKVLDGDLDEFVEASLK 301
PCRF pfam03462
PCRF domain; This domain is found in peptide chain release factors.
 33-218 2.57e-81

PCRF domain; This domain is found in peptide chain release factors.


Pssm-ID: 460929 [Multi-domain]  Cd Length: 192  Bit Score: 246.53  E-value: 2.57e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279652156  33 IQEYEEMMTEPDFWDDQNKAQEVIDKNNALKSVVNGYHELEEEVEDMTATWELLQE-ELDDDVKSDLEQNVLDFKEKVDQ 111
Cdd:pfam03462   5 YEELEALLSDPDVWDDQKRAQKLSKEYSELEPIVEAYREYKQALEDLEEAKELLEDpELAELAEEELEELEKRLEELEEE 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279652156 112 FELQLLLDGPHDANNAILELHPGAGGTESQDWASMLLRMYQRYGEQQGFKVETVDYLPGDEAGVKSVTLLIKGHNAYGYL 191
Cdd:pfam03462  85 LKLLLLPKDPNDDKNAILEIRAGAGGDEAALFAGDLFRMYTRYAERKGWKVEVLDYSETEAGGIKEATFEISGEGAYGRL 164

                         170       180
                  ....*....|....*....|....*..
gi 1279652156 192 KAEKGVHRLVRISPFDSSGRRHTSFAS 218
Cdd:pfam03462 165 KFESGVHRVQRVPPTESQGRIHTSFAT 191
RF-1 pfam00472
RF-1 domain; This domain is found in peptide chain release factors such as RF-1 and RF-2, and ...
 228-338 1.63e-68

RF-1 domain; This domain is found in peptide chain release factors such as RF-1 and RF-2, and a number of smaller proteins of unknown function. This domain contains the peptidyl-tRNA hydrolase activity. The domain contains a highly conserved motif GGQ, where the glutamine is thought to coordinate the water that mediates the hydrolysis.


Pssm-ID: 459823 [Multi-domain]  Cd Length: 111  Bit Score: 210.74  E-value: 1.63e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279652156 228 DEIEIEINPDDITVDTFRASGAGGQHINKTESAIRITHHPTGIVVNNQNERSQIKNREAAMKMLKAKLYQLKLEEQEREM 307
Cdd:pfam00472   1 DEIEIEIDPKDLRIDTFRSSGAGGQHVNKTDSAVRLTHIPTGIVVKCQDERSQHQNREKALKRLRARLYELEEEKEEEKK 80

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1279652156 308 AEIRGEQKEIGWGSQIRSYVFHPYSMVKDHR 338
Cdd:pfam00472  81 RRIKSQVGSGDRSEQIRTYNFKPQSRVKDHR 111
PrfB COG1186
Protein chain release factor PrfB [Translation, ribosomal structure and biogenesis]; Protein ...
 231-340 3.82e-54

Protein chain release factor PrfB [Translation, ribosomal structure and biogenesis]; Protein chain release factor PrfB is part of the Pathway/BioSystem: Translation factors


Pssm-ID: 440799 [Multi-domain]  Cd Length: 140  Bit Score: 174.93  E-value: 3.82e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279652156 231 EIEINPDDITVDTFRASGAGGQHINKTESAIRITHH------------PTGIVVNNQNERSQIKNREAAMKMLKAKLYQL 298
Cdd:COG1186    20 EIEIPESDLRIDTYRASGAGGQNVNKVSSAVRLTHDiassslpdsrltPGGIVVKAQEERSQHQNREDALKRLKALLYEA 99

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1279652156 299 KLEEQERE-MAEIRGEQKEIGWGSQIRsyvfhpySMVKDHRTN 340
Cdd:COG1186   100 ELEPKERRaTKPTRGSKKRRLWGKQIR-------SMVKDLRGN 135
PCRF smart00937
This domain is found in peptide chain release factors;
84-194 1.15e-47

This domain is found in peptide chain release factors;


Pssm-ID: 214923 [Multi-domain]  Cd Length: 116  Bit Score: 157.24  E-value: 1.15e-47
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279652156   84 ELLQEELDDD----VKSDLEQNVLDFKEKVDQFELQLLLDG-PHDANNAILELHPGAGGTESQDWASMLLRMYQRYGEQQ 158
Cdd:smart00937   1 ELLEEEEDDEmrelAEEELEELEAELEEELEELLKLLLLPKdPNDDKNAILEIRAGAGGDEAALFAGDLLRMYLRYAERK 80

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 1279652156  159 GFKVETVDYLPGDEAGVKSVTLLIKGHNAYGYLKAE 194
Cdd:smart00937  81 GWKVEVLDESEGELGGIKEATLKISGEGAYGKLKFE 116
release_prfH TIGR03072
putative peptide chain release factor H; Members of this protein family are bacterial proteins ...
 129-326 5.76e-31

putative peptide chain release factor H; Members of this protein family are bacterial proteins homologous to peptide chain release factors 1 (RF-1, product of the prfA gene), and 2 (RF-2, product of the prfB gene). The member from Escherichia coli K-12, designated prfH, appears to be a pseudogene. This class I release factor is always found as the downstream gene of a two-gene operon. [Protein synthesis, Translation factors]


Pssm-ID: 213768  Cd Length: 200  Bit Score: 116.80  E-value: 5.76e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279652156 129 LELHPGAGGTESQDWASMLLRMYQRYGEQQGFKVETVDYLPGDEAG-VKSVTLLIKGHNAYGYLKAEKGVHRLVRISPFD 207
Cdd:TIGR03072   3 LQLSSAQGPAECCLAVAKALERLTREAAARGVRVEVLEQEPGEVPGtLRSALVSLDGEAAAALADRWEGTLLWICPSPYR 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279652156 208 SSGRRHTSFAScdvIPEFNNDEieiEINPDDITVDTFRASGAGGQHINKTESAIRITHHPTGIVVNNQNERSQIKNREAA 287
Cdd:TIGR03072  83 PHHRRKNWFIG---VQRFSASE---EATEDEIRFETLRSSGPGGQHVNKTESAVRATHLASGISVKVQSERSQHANKRLA 156

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1279652156 288 MKMLKAKLYQLKLEEQEREMAEIRGEQKEIGWGSQIRSY 326
Cdd:TIGR03072 157 TLLLAVRLADLQQEQAAALRAERRTAHHQIERGNPVRVF 195
PRK09256 PRK09256
aminoacyl-tRNA hydrolase;
232-293 1.64e-09

aminoacyl-tRNA hydrolase;


Pssm-ID: 181730 [Multi-domain]  Cd Length: 138  Bit Score: 55.54  E-value: 1.64e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279652156 232 IEINPDDITVDTFRASGAGGQHINKTESAI-------------------------RITHHptG-IVVNNQNERSQIKNRE 285
Cdd:PRK09256    8 LVIPENELEWRFIRASGPGGQNVNKVSTAVelrfdiaasslpefykerllalaghRITKD--GvIVIKAQEFRSQERNRE 85


                  ....*...
gi 1279652156 286 AAMKMLKA 293
Cdd:PRK09256   86 DALERLVA 93
Cast pfam10174
RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part ...
 2-116 4.12e-03

RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part of the CAZ (cytomatrix at the active zone) complex which is involved in determining the site of synaptic vesicle fusion. The C-terminus is a PDZ-binding motif that binds directly to RIM (a small G protein Rab-3A effector). The family also contains four coiled-coil domains.


Pssm-ID: 431111 [Multi-domain]  Cd Length: 766  Bit Score: 39.03  E-value: 4.12e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279652156   2 ELSEIKRNIDEYRNNLAQIRGSLDLENKEtNIQEYEEMMTEPDFWDDQNKA---QEVID-KNNALKSVVNGYHELEEEVE 77
Cdd:pfam10174 179 EDWERTRRIAEAEMQLGHLEVLLDQKEKE-NIHLREELHRRNQLQPDPAKTkalQTVIEmKDTKISSLERNIRDLEDEVQ 257

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1279652156  78 DMTATWELLQEELDDDVKS-DLEQNVLDF-KEKVDQFELQL 116
Cdd:pfam10174 258 MLKTNGLLHTEDREEEIKQmEVYKSHSKFmKNKIDQLKQEL 298
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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