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Conserved domains on  [gi|1293409797|ref|WP_100669939|]
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MULTISPECIES: carbohydrate ABC transporter permease [Sinorhizobium]

Protein Classification

carbohydrate ABC transporter permease( domain architecture ID 11417684)

carbohydrate ABC transporter permease, part of a periplasmic binding protein (PBP)-dependent ABC transporter may be involved in transport of one or more of a variety of mono-, di-, or polysaccharides, such as trehalose/maltose (MalG) and alginate (AlgM); responsible for translocation of the substrate across the membrane

Gene Ontology:  GO:0055085|GO:0008643
PubMed:  19234479|27273632
TCDB:  3.A.1.1.

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
UgpE COG0395
ABC-type glycerol-3-phosphate transport system, permease component [Carbohydrate transport and ...
 19-294 4.68e-105

ABC-type glycerol-3-phosphate transport system, permease component [Carbohydrate transport and metabolism];


:

Pssm-ID: 440164 [Multi-domain]  Cd Length: 282  Bit Score: 307.41  E-value: 4.68e-105
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1293409797  19 RRGPVGSVLVHAALIAASIAMIYPLLWMISASVRPEDEIFAST-SLWPSSVDFSSYLRGWFglDVSFGRFFWNSLVIAVL 97
Cdd:COG0395     8 RRRRLGRILLYLLLILLALLFLFPLYWMVVTSFKPPAEIFSGPpSLLPSEFTLENYRAAFT--DGPFGRYLLNSLIVAVV 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1293409797  98 TVVGNVVACSLAAYAFARLRFAGRNFWFAIMLGTMMIPYHVTLIPQYVLFLDLGWVNTFLPLVVPKFLASDAFFIFLMVQ 177
Cdd:COG0395    86 STVLSLLLSSLAAYALARFRFRGRKLLFLLILATLMIPGQVLLIPLYLLFRQLGLLNTYWGLILPYLAFGLPFGIFLLRQ 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1293409797 178 FFRGIPRELDEAAMMDGCGAWRIYWKIMLPLSLPVLATAAIFSFIWTWDDFFGPLIYLNDMNSYTIQLGLRTFVDSSSTs 257
Cdd:COG0395   166 FFRSIPRELEEAARIDGASEFRIFWRIVLPLSKPALATVAIFTFIGAWNDFLWPLILLTSPDLRTLPVGLASFQGQYGT- 244

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1293409797 258 DWGGLFAMSTLSLVPVFFFFLFFQRLLIEGIATTGMK 294
Cdd:COG0395   245 DWGLLMAAAVIATLPVLILFLFLQRYFVRGLTAGAVK 281
 
Name Accession Description Interval E-value
UgpE COG0395
ABC-type glycerol-3-phosphate transport system, permease component [Carbohydrate transport and ...
 19-294 4.68e-105

ABC-type glycerol-3-phosphate transport system, permease component [Carbohydrate transport and metabolism];


Pssm-ID: 440164 [Multi-domain]  Cd Length: 282  Bit Score: 307.41  E-value: 4.68e-105
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1293409797  19 RRGPVGSVLVHAALIAASIAMIYPLLWMISASVRPEDEIFAST-SLWPSSVDFSSYLRGWFglDVSFGRFFWNSLVIAVL 97
Cdd:COG0395     8 RRRRLGRILLYLLLILLALLFLFPLYWMVVTSFKPPAEIFSGPpSLLPSEFTLENYRAAFT--DGPFGRYLLNSLIVAVV 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1293409797  98 TVVGNVVACSLAAYAFARLRFAGRNFWFAIMLGTMMIPYHVTLIPQYVLFLDLGWVNTFLPLVVPKFLASDAFFIFLMVQ 177
Cdd:COG0395    86 STVLSLLLSSLAAYALARFRFRGRKLLFLLILATLMIPGQVLLIPLYLLFRQLGLLNTYWGLILPYLAFGLPFGIFLLRQ 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1293409797 178 FFRGIPRELDEAAMMDGCGAWRIYWKIMLPLSLPVLATAAIFSFIWTWDDFFGPLIYLNDMNSYTIQLGLRTFVDSSSTs 257
Cdd:COG0395   166 FFRSIPRELEEAARIDGASEFRIFWRIVLPLSKPALATVAIFTFIGAWNDFLWPLILLTSPDLRTLPVGLASFQGQYGT- 244

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1293409797 258 DWGGLFAMSTLSLVPVFFFFLFFQRLLIEGIATTGMK 294
Cdd:COG0395   245 DWGLLMAAAVIATLPVLILFLFLQRYFVRGLTAGAVK 281
malG PRK10998
maltose ABC transporter permease MalG;
29-294 1.04e-32

maltose ABC transporter permease MalG;


Pssm-ID: 182891  Cd Length: 296  Bit Score: 122.12  E-value: 1.04e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1293409797  29 HAALIAASIAMIYPLLWMISASVRPEDeiFASTSLWPSSVDFSSYlRGWFGLDVSFG------------RFFWNSLVIAV 96
Cdd:PRK10998   17 HLLLLGFIALIMFPLLMVIAISLREGN--FATGSLIPEQISWEHW-KLALGFSVEHAdgrvtpppfpvlLWLWNSVKVAG 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1293409797  97 LTVVGNVVACSLAAYAFARLRFAGRNFWFAIMLGTMMIPYHVTLIPQYVLFLDLGWVNTFLPL-----VVPKFLASDAFF 171
Cdd:PRK10998   94 ITAIGIVALSTTCAYAFARMRFKGKATLLKGMLIFQMFPAVLSLVALYALFDRLGQYIPFIGLnthggVIFAYLGGIALH 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1293409797 172 IFLMVQFFRGIPRELDEAAMMDGCGAWRIYWKIMLPLSLPVLATAAIFSFIWTWDDFFGPLIYLNDMNSYTIQLGLRTFV 251
Cdd:PRK10998  174 VWTIKGYFETIDSSLEEAAALDGATPWQAFRLVLLPLSVPILAVVFILSFIAAITEVPVASLLLRDVNSYTLAVGMQQYL 253

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 1293409797 252 DSSSTSdWGGLFAMSTLSLVPVFFFFLFFQRLLIEGIATTGMK 294
Cdd:PRK10998  254 NPQNYL-WGDFAAAAVLSAIPITVVFLLAQRWLVGGLTAGGVK 295
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 88-273 1.41e-16

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 76.16  E-value: 1.41e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1293409797  88 FWNSLVIAVLTVVGNVVACSLAAYAFARLRFAGRNFWFAIMLGTMMIPYHVTLIPQYVLFLDLGWVNTFLPLVVPKFLAS 167
Cdd:cd06261     1 LLNTLLLALIATLLALVLGLLLGIILARKRGKLDRLLRRIIDLLLSLPSLVLGLLLVLLFGVLLGWGILPGLGLPALILA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1293409797 168 DAFFIFLMVQFFRG----IPRELDEAAMMDGCGAWRIYWKIMLPLSLPVLATAAIFSFIWTWDDFFGPLIYLNdMNSYTI 243
Cdd:cd06261    81 LLLIAPFARLIRRAalesIPKDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFARALGEFALVSFLGG-GEAPGP 159

                         170       180       190
                  ....*....|....*....|....*....|
gi 1293409797 244 QLGLRTFVDSSSTSDWGGLFAMSTLSLVPV 273
Cdd:cd06261   160 GTGLLLIFAILFPGDLGVAAAVALILLLLS 189
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
 108-271 1.10e-12

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 65.01  E-value: 1.10e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1293409797 108 LAAYAFARLRFAGRNFWFAIMLGTMMIPYHVTLIPQYVLFLDLGWVNTFLPLVVPKFLASDAFFIFLMVQFFRGIPRELD 187
Cdd:pfam00528   4 LGIIAALRRGRRLDRLLRPLIDLLQALPSFVLAILLVVIAILSILGHGILPAIILALLGWAGYARLIRRAALRSLPSDLV 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1293409797 188 EAAMMDGCGAWRIYWKIMLPLSLPVLATAAIFSFIWTWDDFFGPLIYLND--MNSYTIQLGLRTFVDSSSTSDWGGLFAM 265
Cdd:pfam00528  84 EAARALGASRWQIFRKIILPNALPPILTGLALAFGGALGGAVLLEFLGSWpgLGLLLIEAILGYDYPEIQGPVLAAALIL 163


                  ....*.
gi 1293409797 266 STLSLV 271
Cdd:pfam00528 164 LLLNLL 169
PhnU2 TIGR03262
putative 2-aminoethylphosphonate ABC transporter, permease protein; [Transport and binding ...
 32-233 7.83e-06

putative 2-aminoethylphosphonate ABC transporter, permease protein; [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 274495 [Multi-domain]  Cd Length: 546  Bit Score: 46.98  E-value: 7.83e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1293409797  32 LIAASIAMIYPLLWMISASVRPEDEIFASTSlwpssvDFSSYLRgwfglDVSFGRFFWNSLVIAVLTVVGNVVACSLAAY 111
Cdd:TIGR03262  11 ILALLLFLLLPLLALLTKSVYDSDGDFIGLA------NFAEYFA-----TPGLLQSLGNSLTVSAIVTAIVVPLAFAFAY 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1293409797 112 AFARLRFAGRNFWFAIMLGTMMIPYHVTLIPQYVLFLDLGWVNTFLPLV----VPKFLASDAFFIF-----LMVQFFRGI 182
Cdd:TIGR03262  80 ALTRSRIPGKGAFRLVALLPLLAPSLLPAISLIYLFGNQGLLKGLLGGFsiygFWGIVIGEVFYTFphalmILVTALSLA 159

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1293409797 183 PRELDEAAMMDGCGAWRIYWKIMLPLSLPVLATAAIFSFIWTWDDFFGPLI 233
Cdd:TIGR03262 160 DGRLYEAARAMGASPWRTFFTVTLPGAKYGLISAAFVVFTLVITDFGVPKV 210
 
Name Accession Description Interval E-value
UgpE COG0395
ABC-type glycerol-3-phosphate transport system, permease component [Carbohydrate transport and ...
 19-294 4.68e-105

ABC-type glycerol-3-phosphate transport system, permease component [Carbohydrate transport and metabolism];


Pssm-ID: 440164 [Multi-domain]  Cd Length: 282  Bit Score: 307.41  E-value: 4.68e-105
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1293409797  19 RRGPVGSVLVHAALIAASIAMIYPLLWMISASVRPEDEIFAST-SLWPSSVDFSSYLRGWFglDVSFGRFFWNSLVIAVL 97
Cdd:COG0395     8 RRRRLGRILLYLLLILLALLFLFPLYWMVVTSFKPPAEIFSGPpSLLPSEFTLENYRAAFT--DGPFGRYLLNSLIVAVV 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1293409797  98 TVVGNVVACSLAAYAFARLRFAGRNFWFAIMLGTMMIPYHVTLIPQYVLFLDLGWVNTFLPLVVPKFLASDAFFIFLMVQ 177
Cdd:COG0395    86 STVLSLLLSSLAAYALARFRFRGRKLLFLLILATLMIPGQVLLIPLYLLFRQLGLLNTYWGLILPYLAFGLPFGIFLLRQ 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1293409797 178 FFRGIPRELDEAAMMDGCGAWRIYWKIMLPLSLPVLATAAIFSFIWTWDDFFGPLIYLNDMNSYTIQLGLRTFVDSSSTs 257
Cdd:COG0395   166 FFRSIPRELEEAARIDGASEFRIFWRIVLPLSKPALATVAIFTFIGAWNDFLWPLILLTSPDLRTLPVGLASFQGQYGT- 244

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1293409797 258 DWGGLFAMSTLSLVPVFFFFLFFQRLLIEGIATTGMK 294
Cdd:COG0395   245 DWGLLMAAAVIATLPVLILFLFLQRYFVRGLTAGAVK 281
MalG COG3833
ABC-type maltose transport system, permease component MalG [Carbohydrate transport and ...
 17-294 6.13e-66

ABC-type maltose transport system, permease component MalG [Carbohydrate transport and metabolism];


Pssm-ID: 443045 [Multi-domain]  Cd Length: 282  Bit Score: 207.70  E-value: 6.13e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1293409797  17 TGRRGPVGSVLVHAALIAASIAMIYPLLWMISASVRPEDEIFaSTSLWPSSVDFSSYLRGWFGLDvsFGRFFWNSLVIAV 96
Cdd:COG3833     7 RKRRRRLKLGLRHLVLIILAIIALFPILWVVSASFNPGGSLY-SSSLIPENFTLENYKKLFTETP--FLRWFLNSLIVAV 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1293409797  97 LTVVGNVVACSLAAYAFARLRFAGRNFWFAIMLGTMMIPYHVTLIPQYVLFLDLGWVNTFLPLVVPKFLASDAFFIFLMV 176
Cdd:COG3833    84 VTAIISVFLAALAAYAFSRFRFKGRKAGLLALLLLQMFPAFLALVALYLLLSALGLLNTLLGLILVYLGGAIPFNTWLMK 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1293409797 177 QFFRGIPRELDEAAMMDGCGAWRIYWKIMLPLSLPVLATAAIFSFIWTWDDFFGPLIYLNDMNSYTIQLGLRTFVDSSST 256
Cdd:COG3833   164 GYFDTIPKELDEAAKIDGASHFQIFFRIILPLAKPILAVVALLSFIGPWNDFILASVLLRSPENYTLAVGLYSFVSDQRN 243

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1293409797 257 SDWGGLFAMSTLSLVPVFFFFLFFQRLLIEGIATTGMK 294
Cdd:COG3833   244 TNWGVFAAGAVLVAIPIVILFLFLQRYLVSGLTAGGVK 281
malG PRK10998
maltose ABC transporter permease MalG;
29-294 1.04e-32

maltose ABC transporter permease MalG;


Pssm-ID: 182891  Cd Length: 296  Bit Score: 122.12  E-value: 1.04e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1293409797  29 HAALIAASIAMIYPLLWMISASVRPEDeiFASTSLWPSSVDFSSYlRGWFGLDVSFG------------RFFWNSLVIAV 96
Cdd:PRK10998   17 HLLLLGFIALIMFPLLMVIAISLREGN--FATGSLIPEQISWEHW-KLALGFSVEHAdgrvtpppfpvlLWLWNSVKVAG 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1293409797  97 LTVVGNVVACSLAAYAFARLRFAGRNFWFAIMLGTMMIPYHVTLIPQYVLFLDLGWVNTFLPL-----VVPKFLASDAFF 171
Cdd:PRK10998   94 ITAIGIVALSTTCAYAFARMRFKGKATLLKGMLIFQMFPAVLSLVALYALFDRLGQYIPFIGLnthggVIFAYLGGIALH 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1293409797 172 IFLMVQFFRGIPRELDEAAMMDGCGAWRIYWKIMLPLSLPVLATAAIFSFIWTWDDFFGPLIYLNDMNSYTIQLGLRTFV 251
Cdd:PRK10998  174 VWTIKGYFETIDSSLEEAAALDGATPWQAFRLVLLPLSVPILAVVFILSFIAAITEVPVASLLLRDVNSYTLAVGMQQYL 253

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 1293409797 252 DSSSTSdWGGLFAMSTLSLVPVFFFFLFFQRLLIEGIATTGMK 294
Cdd:PRK10998  254 NPQNYL-WGDFAAAAVLSAIPITVVFLLAQRWLVGGLTAGGVK 295
PRK10973 PRK10973
sn-glycerol-3-phosphate ABC transporter permease UgpE;
29-288 2.15e-30

sn-glycerol-3-phosphate ABC transporter permease UgpE;


Pssm-ID: 182875 [Multi-domain]  Cd Length: 281  Bit Score: 115.60  E-value: 2.15e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1293409797  29 HAALIAASIAMIYPLLWMISASVRPEDEIFA-------STSLWPSSVDFssYLRGWFGLDVSFGRFFWNSLVIAVLTVVG 101
Cdd:PRK10973   13 HTMLILGIAVILFPLYVAFVAATLDKQAVFAvpmtlipGTHLLENIANI--WVNGVGNNSAPFGRMLLNSFVMAFSITVG 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1293409797 102 NVVACSLAAYAFARLRFAGRNFWFAIMLGTMMIPYHVTLIPQYVLFLDLGWVNTFLPLVVPkfLASDAFFIFLMVQFFRG 181
Cdd:PRK10973   91 KITVSMLSAFAIVWFRFPLRNLFFWMIFITLMLPVEVRIFPTVEVIANLKMLDSYAGLTLP--LMASATATFLFRQFFMT 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1293409797 182 IPRELDEAAMMDGCGAWRIYWKIMLPLSLPVLATAAIFSFIWTWDDFFGPLIYLNDMNSYTIQLGLRTFVDSS-STSDWG 260
Cdd:PRK10973  169 LPDELVEAARIDGASPMRFFWDIVLPLSKTNLAALFVITFIYGWNQYLWPLLIITDVSLGTAVAGIKGMIATGeGTTEWN 248

                         250       260
                  ....*....|....*....|....*...
gi 1293409797 261 GLFAMSTLSLVPVFFFFLFFQRLLIEGI 288
Cdd:PRK10973  249 QVMAAMLLTLIPPVVIVLAMQRAFVRGL 276
PotC COG1177
ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport ...
 20-228 2.48e-24

ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism];


Pssm-ID: 440790 [Multi-domain]  Cd Length: 262  Bit Score: 98.65  E-value: 2.48e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1293409797  20 RGPVGSVLVHAALIAASIAMIYPLLWMISASVRPEDeifaSTSLWPSSVDFSSYLRGWfgLDVSFGRFFWNSLVIAVLTV 99
Cdd:COG1177     1 SSRLGRLLLRLFLALVLLFLYLPILVLVLYSFNDSW----FLTFPPEGFTLRWYAELF--SDPRLLDALLNSLLIALLST 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1293409797 100 VGNVVACSLAAYAFARLRFAGRNFWFAIMLGTMMIPYHVTLIPQYVLFLDLGWVNTFLPLVVPKFLASDAFFIFLMVQFF 179
Cdd:COG1177    75 LLATVLGTPAALALARYRFRGRRLLLALLLLPLVVPGIVLGVALLLLFSALGLSGGLWGLILAHVVFTLPFVVLVVLARL 154

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 1293409797 180 RGIPRELDEAAMMDGCGAWRIYWKIMLPLSLPVLATAAIFSFIWTWDDF 228
Cdd:COG1177   155 QGFDPSLEEAARDLGASPWQTFRRVTLPLIAPGILAGALLAFTLSFDEF 203
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 88-273 1.41e-16

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 76.16  E-value: 1.41e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1293409797  88 FWNSLVIAVLTVVGNVVACSLAAYAFARLRFAGRNFWFAIMLGTMMIPYHVTLIPQYVLFLDLGWVNTFLPLVVPKFLAS 167
Cdd:cd06261     1 LLNTLLLALIATLLALVLGLLLGIILARKRGKLDRLLRRIIDLLLSLPSLVLGLLLVLLFGVLLGWGILPGLGLPALILA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1293409797 168 DAFFIFLMVQFFRG----IPRELDEAAMMDGCGAWRIYWKIMLPLSLPVLATAAIFSFIWTWDDFFGPLIYLNdMNSYTI 243
Cdd:cd06261    81 LLLIAPFARLIRRAalesIPKDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFARALGEFALVSFLGG-GEAPGP 159

                         170       180       190
                  ....*....|....*....|....*....|
gi 1293409797 244 QLGLRTFVDSSSTSDWGGLFAMSTLSLVPV 273
Cdd:cd06261   160 GTGLLLIFAILFPGDLGVAAAVALILLLLS 189
PotB COG1176
ABC-type spermidine/putrescine transport system, permease component I [Amino acid transport ...
 19-224 2.85e-16

ABC-type spermidine/putrescine transport system, permease component I [Amino acid transport and metabolism];


Pssm-ID: 440789 [Multi-domain]  Cd Length: 287  Bit Score: 77.11  E-value: 2.85e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1293409797  19 RRGPVGSVLVHAALIAASIAMIYPLLWMISASVRPEDEIFASTSLWpssvDFSSYLRgwFGLDVSFGRFFWNSLVIAVLT 98
Cdd:COG1176     6 RRRLRPLLLLLPALLWLLLFFVLPLLLLLVYSFTTRDPYGGVVPGF----TLENYAR--LFTDPLYLKVLLRTLWIALLT 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1293409797  99 VVGNVVACSLAAYAFARLRFAGRNFWFAIMLGTMMIPYHVTLIPQYVLFLDLGWVNTFL--------PLvvpKFLASDAF 170
Cdd:COG1176    80 TLICLLLGYPIAYFLARAPPRWRNLLLLLVILPFWTSFLVRTYAWIVLLGRNGLLNSLLlalglidePL---RLLYTEFA 156

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1293409797 171 FIFLMVQFF------------RGIPRELDEAAMMDGCGAWRIYWKIMLPLSLPVLATAAIFSFIWT 224
Cdd:COG1176   157 VVIGLVYVYlpfmvlplyaalEKIDPSLLEAARDLGASPWQTFRRVILPLSLPGIIAGSLLVFIPA 222
UgpA COG1175
ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism];
6-228 2.98e-16

ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism];


Pssm-ID: 440788 [Multi-domain]  Cd Length: 298  Bit Score: 77.10  E-value: 2.98e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1293409797   6 MSSVTAAPPVPTGRRGPV-GSVLVHAALIAASIAMIYPLLWMISASVRPEDEIfastSLWPSSVDFSSYLRgWFGlDVSF 84
Cdd:COG1175     1 MTTTTSAAARRRRRRRRLaAYLFLLPALLLLLVFVLYPLLYTLYLSFTDWNLL----GPPPEFVGLDNYAR-LFT-DPRF 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1293409797  85 GRFFWNSLVIAVLTVVGNVVACSLAAYAFARlRFAGRNFWFAIMLGTMMIPYHVT-LIPQYVLFLDLGWVNTFLPLV--- 160
Cdd:COG1175    75 WNALGNTLLFTVVSVPLQLVLGLLLALLLNR-KLRGRGFFRTLFFLPWVISPVVVaLIWKWLFNPDYGLLNALLGALgle 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1293409797 161 VPKFLASDAFFIFLMV-----QFF-----------RGIPRELDEAAMMDGCGAWRIYWKIMLPLSLPVLATAAIFSFIWT 224
Cdd:COG1175   154 PINWLGDPSLALPAVIivtvwKGTgfnmliflaglQSIPRELYEAARIDGASPWQRFRRITLPLLRPTILFVLVLSTIGA 233


                  ....
gi 1293409797 225 WDDF 228
Cdd:COG1175   234 LQVF 237
FbpB COG1178
ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];
17-233 7.44e-15

ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440791 [Multi-domain]  Cd Length: 538  Bit Score: 74.43  E-value: 7.44e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1293409797  17 TGRRGPVGSVLVHAALIAASIAMIYPLLWMISASVRPED----EIFASTSLWpssvdfssylrgwfgldvsfgRFFWNSL 92
Cdd:COG1178     2 STRPRRRPRLLLLLLALLLALLVLLPLLALLLRAFTDGLanfwALLSDPYLW---------------------RALGNTL 60

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1293409797  93 VIAVLTVVGNVVACSLAAYAFARLRFAGRNFWFAIMLGTMMIPYHVTLIPQYVLFLDLGWVNTFLPLVVPKFLAS----- 167
Cdd:COG1178    61 LLALLVTLLSLLLGVPLAWLLARTDFPGRRLLRWLLLLPLALPPYVVALAWIALFGPNGLLNTLLRALFGLEPPDiyglg 140

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1293409797 168 -----DAFFIF-----LMVQFFRGIPRELDEAAMMDGCGAWRIYWKIMLPLSLPVLATAAIFSFIWTWDDFFGPLI 233
Cdd:COG1178   141 giilvLVLFNYpyvylLLRAALRSIDASLEEAARSLGASPWRAFRRVTLPLLRPAIAAGALLVFLLCLADFGTPLV 216
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
 108-271 1.10e-12

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 65.01  E-value: 1.10e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1293409797 108 LAAYAFARLRFAGRNFWFAIMLGTMMIPYHVTLIPQYVLFLDLGWVNTFLPLVVPKFLASDAFFIFLMVQFFRGIPRELD 187
Cdd:pfam00528   4 LGIIAALRRGRRLDRLLRPLIDLLQALPSFVLAILLVVIAILSILGHGILPAIILALLGWAGYARLIRRAALRSLPSDLV 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1293409797 188 EAAMMDGCGAWRIYWKIMLPLSLPVLATAAIFSFIWTWDDFFGPLIYLND--MNSYTIQLGLRTFVDSSSTSDWGGLFAM 265
Cdd:pfam00528  84 EAARALGASRWQIFRKIILPNALPPILTGLALAFGGALGGAVLLEFLGSWpgLGLLLIEAILGYDYPEIQGPVLAAALIL 163


                  ....*.
gi 1293409797 266 STLSLV 271
Cdd:pfam00528 164 LLLNLL 169
FbpB COG1178
ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];
12-222 1.12e-11

ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440791 [Multi-domain]  Cd Length: 538  Bit Score: 64.80  E-value: 1.12e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1293409797  12 APPVPTGRRGPVGSVLVHAALIAASIAMIYPLLWMISASVRPedeifastsLWPSSVDFSSYLRGWFglDVSFGRFFWNS 91
Cdd:COG1178   275 ARRPRRVKLGRWRWLALALCLLLVLLGLLLPLLALLLWSLTK---------ALDDNLTLDNYRFVLL--DPSLLRALLNS 343

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1293409797  92 LVIAVLTVVGNVVACSLAAYAFARLRFAGRNFWFAIMLGTMMIP---YHVTLIPQYVLFLDLGWVNTFLPLVVPKFLASD 168
Cdd:COG1178   344 LLLALLAALLAVLLALLLAYLVRRRRGRLARLLDRLAMLPYAVPgivLGLGLLLLFNRPLPLLLYGTLAILVLAYVVRFL 423

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1293409797 169 AFFIFLMVQFFRGIPRELDEAAMMDGCGAWRIYWKIMLPLSLPVLATAAIFSFI 222
Cdd:COG1178   424 PFALRSLEAALAQIDPSLEEAARSLGASPLRTLRRVTLPLLRPGLLAAALLVFV 477
CysU COG0555
ABC-type sulfate transport system, permease component [Inorganic ion transport and metabolism]; ...
 88-221 9.36e-10

ABC-type sulfate transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440321 [Multi-domain]  Cd Length: 268  Bit Score: 58.22  E-value: 9.36e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1293409797  88 FWNSLVIAVLTVVGNVVACSLAAYAFARLRFAGRNFWFAIMLGTMMIPYHVTLIPQYVLFLDLGWVNTFLPLVVPKFLAS 167
Cdd:COG0555    56 LKLSLGTALIAALINLVFGLPLAWVLVRYRFPGKRLVDALVDLPFALPTAVAGIALLLLFGPNGWLGQLLAPLGIKVAFT 135

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1293409797 168 DA------FFIFL-----MVQ-FFRGIPRELDEAAMMDGCGAWRIYWKIMLPLSLPVLATAAIFSF 221
Cdd:COG0555   136 PLgivlaqTFVSLpfvvrTVQpVLEELDPELEEAAATLGASRWQTFRRVILPLLLPALLTGFALAF 201
potC PRK09500
spermidine/putrescine ABC transporter membrane protein; Reviewed
 88-227 4.96e-09

spermidine/putrescine ABC transporter membrane protein; Reviewed


Pssm-ID: 236542 [Multi-domain]  Cd Length: 256  Bit Score: 55.76  E-value: 4.96e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1293409797  88 FWNSLVIAVLTVVGNVVACSLAAYAFARLRFAGRNFWFAIMLGTMMIPYHVTLIPQYVLFLDLGWVNTFLPLVVPKFLAS 167
Cdd:PRK09500   59 AQHSLTMAVFSATFATLIGSLTAVALYRYRFRGKKFVSGMLFVVMMSPDIVMAISLLVLFMLLGIQLGFWSLLFAHITFC 138

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1293409797 168 DAFFIFLMVQFFRGIPRELDEAAMMDGCGAWRIYWKIMLPLSLPVLATAAIFSFIWTWDD 227
Cdd:PRK09500  139 LPFVVVTVYSRLKGFDVRMLEAAKDLGASEFTILRKIILPLALPAVAAGWLLSFTLSLDD 198
PhnU2 TIGR03262
putative 2-aminoethylphosphonate ABC transporter, permease protein; [Transport and binding ...
 32-233 7.83e-06

putative 2-aminoethylphosphonate ABC transporter, permease protein; [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 274495 [Multi-domain]  Cd Length: 546  Bit Score: 46.98  E-value: 7.83e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1293409797  32 LIAASIAMIYPLLWMISASVRPEDEIFASTSlwpssvDFSSYLRgwfglDVSFGRFFWNSLVIAVLTVVGNVVACSLAAY 111
Cdd:TIGR03262  11 ILALLLFLLLPLLALLTKSVYDSDGDFIGLA------NFAEYFA-----TPGLLQSLGNSLTVSAIVTAIVVPLAFAFAY 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1293409797 112 AFARLRFAGRNFWFAIMLGTMMIPYHVTLIPQYVLFLDLGWVNTFLPLV----VPKFLASDAFFIF-----LMVQFFRGI 182
Cdd:TIGR03262  80 ALTRSRIPGKGAFRLVALLPLLAPSLLPAISLIYLFGNQGLLKGLLGGFsiygFWGIVIGEVFYTFphalmILVTALSLA 159

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1293409797 183 PRELDEAAMMDGCGAWRIYWKIMLPLSLPVLATAAIFSFIWTWDDFFGPLI 233
Cdd:TIGR03262 160 DGRLYEAARAMGASPWRTFFTVTLPGAKYGLISAAFVVFTLVITDFGVPKV 210
cysT CHL00187
sulfate transport protein; Provisional
 91-221 8.34e-05

sulfate transport protein; Provisional


Pssm-ID: 214388 [Multi-domain]  Cd Length: 237  Bit Score: 43.08  E-value: 8.34e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1293409797  91 SLVIAVLTVVGNVVACSLAAYAFARLRFAGRNFWFAIMLGTMMIPYHVTLIPQYVLFLDLGW------------VNTFLP 158
Cdd:CHL00187   60 TLSMALIAALINGFFGLLIAWVLVRYNFPGKRLLDAAVDLPFALPTSVAGLTLATVYGDNGWighllshlgiqiVFTKLG 139

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1293409797 159 LVVPKFLASDAFFIFLMVQFFRGIPRELDEAAMMDGCGAWRIYWKIMLPLSLPVLATAAIFSF 221
Cdd:CHL00187  140 VLLAMIFVSFPFVVRTIQPVLQEIEKELEEAAWSLGASPWQTFWKVIFPPLIPALLTGLALTF 202
modB PRK09421
molybdate ABC transporter permease subunit;
91-221 7.83e-04

molybdate ABC transporter permease subunit;


Pssm-ID: 181841  Cd Length: 229  Bit Score: 39.90  E-value: 7.83e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1293409797  91 SLVIAVLTVVGNVVACSLAAYAFARLRFAGRNFWFAIMLGTMMIPYHVTlipQYVLFLDLG-------WVNTFLPLVVP- 162
Cdd:PRK09421   14 SLKVSSVAVLFSLPFGILVAWLLARCRFPGKSLLDSLLHLPLVLPPVVT---GYLLLISMGrrgfigqWLYEWFGISFAf 90

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1293409797 163 ----KFLASDAFFIFLMVQFFR----GIPRELDEAAMMDGCGAWRIYWKIMLPLSLPVLATAAIFSF 221
Cdd:PRK09421   91 swrgAALAAAVMAFPLMVRAIRlsleAVDRKLEQAARTLGASPWRVFFTITLPLTLPGIIAGTVLAF 157
YnjC COG4135
ABC-type uncharacterized transport system YnjBCD, permease component [General function ...
 18-217 2.98e-03

ABC-type uncharacterized transport system YnjBCD, permease component [General function prediction only];


Pssm-ID: 443310 [Multi-domain]  Cd Length: 564  Bit Score: 39.08  E-value: 2.98e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1293409797  18 GRRGPVGSVLVHAALIAASIAMIYP-------LLWMISASVRPEDeifastsLWPSSVDFSSYLRGWFGLdvsfGRFFWN 90
Cdd:COG4135   292 GRRGLGDPALRRLGLALMLLIALLSllglallLLWSFAGRWRFPD-------ALPSSWTLRFWQRAAPGL----LEPLGN 360

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1293409797  91 SLVIAVLTVVGNVVACSLAAYAFARLRFAGRNFWFAIMLGTMMIPyHVTLIP-QYVLFLDLGWVNTFLPLVvpkflASDA 169
Cdd:COG4135   361 TLLLALASALIALVLVLACLEAEARRGRRPGRRALWLLYLPLLVP-QIAFLFgLQVLLLRLGLDGTWLAVI-----WAHL 434

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1293409797 170 FFIFLMVQF-----FRGIPRELDEAAMMDGCGAWRIYWKIMLPLSLPVLATAA 217
Cdd:COG4135   435 VFVLPYVFLslagpWRALDPRYAQVAASLGASPWRVFWRVKLPLLLRPILTAA 487
TauC COG0600
ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion ...
 78-225 4.36e-03

ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440365 [Multi-domain]  Cd Length: 254  Bit Score: 37.82  E-value: 4.36e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1293409797  78 FGLDVSFGRFFWNSLVIAVLTVVGNVVACSLA---AYAFARLRFAgRNFWFAIMLGTMMIPyHVTLIPQYVLFLDLGWvn 154
Cdd:COG0600    50 LVELLASGELWEHLLASLLRVLLGFALAALLGvplGLLLGLSRLL-RRLLDPLLVFLRPIP-PLALAPLLILWFGIGE-- 125

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1293409797 155 tfLPLVVPKFLASdAFFIFLMVQF-FRGIPRELDEAAMMDGCGAWRIYWKIMLPLSLPVLATAAIFSFIWTW 225
Cdd:COG0600   126 --ASKIFVIFLGA-FFPILLNTAAgVRSVDPELLELARSLGASRWQILRKVVLPAALPYIFTGLRIALGLAW 194
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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