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Conserved domains on  [gi|1296617182|ref|WP_100779139|]
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MULTISPECIES: protein-L-isoaspartate(D-aspartate) O-methyltransferase [Lelliottia]

Protein Classification

protein-L-isoaspartate O-methyltransferase( domain architecture ID 10011370)

protein-L-isoaspartate O-methyltransferase catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues

EC:  2.1.1.77
Gene Ontology:  GO:0004719|GO:0030091
PubMed:  1860862
SCOP:  4000666

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
pcm PRK00312
protein-L-isoaspartate(D-aspartate) O-methyltransferase;
1-208 1.46e-132

protein-L-isoaspartate(D-aspartate) O-methyltransferase;


:

Pssm-ID: 178974 [Multi-domain]  Cd Length: 212  Bit Score: 370.69  E-value: 1.46e-132
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617182   1 MVSKRVQALLTQLRTQGITDERVLEAISQVPREKFVDEAFEHKAWENVALPIGQGQTISQPYMVARMTELLELTPESRVL 80
Cdd:PRK00312    4 MESERFARLVLRLRAEGILDERVLEAIEATPRELFVPEAFKHKAYENRALPIGCGQTISQPYMVARMTELLELKPGDRVL 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617182  81 EIGTGSGYQTAILAHLVHHVCSVERIKGLQWHARRRLKQLDLHNVSTRHGDGWQGWQARAPFDAIIVTAAPLEIPAALLA 160
Cdd:PRK00312   84 EIGTGSGYQAAVLAHLVRRVFSVERIKTLQWEAKRRLKQLGLHNVSVRHGDGWKGWPAYAPFDRILVTAAAPEIPRALLE 163

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 1296617182 161 QLDDGGILVLPVGDE-QQLLKRVCRRGGEFIIDTVEAVRFVPLVKGELA 208
Cdd:PRK00312  164 QLKEGGILVAPVGGEeQQLLTRVRKRGGRFEREVLEEVRFVPLVKGELA 212
 
Name Accession Description Interval E-value
pcm PRK00312
protein-L-isoaspartate(D-aspartate) O-methyltransferase;
1-208 1.46e-132

protein-L-isoaspartate(D-aspartate) O-methyltransferase;


Pssm-ID: 178974 [Multi-domain]  Cd Length: 212  Bit Score: 370.69  E-value: 1.46e-132
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617182   1 MVSKRVQALLTQLRTQGITDERVLEAISQVPREKFVDEAFEHKAWENVALPIGQGQTISQPYMVARMTELLELTPESRVL 80
Cdd:PRK00312    4 MESERFARLVLRLRAEGILDERVLEAIEATPRELFVPEAFKHKAYENRALPIGCGQTISQPYMVARMTELLELKPGDRVL 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617182  81 EIGTGSGYQTAILAHLVHHVCSVERIKGLQWHARRRLKQLDLHNVSTRHGDGWQGWQARAPFDAIIVTAAPLEIPAALLA 160
Cdd:PRK00312   84 EIGTGSGYQAAVLAHLVRRVFSVERIKTLQWEAKRRLKQLGLHNVSVRHGDGWKGWPAYAPFDRILVTAAAPEIPRALLE 163

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 1296617182 161 QLDDGGILVLPVGDE-QQLLKRVCRRGGEFIIDTVEAVRFVPLVKGELA 208
Cdd:PRK00312  164 QLKEGGILVAPVGGEeQQLLTRVRKRGGRFEREVLEEVRFVPLVKGELA 212
pimt TIGR00080
protein-L-isoaspartate(D-aspartate) O-methyltransferase; This is an all-kingdom (but not all ...
 1-208 2.36e-112

protein-L-isoaspartate(D-aspartate) O-methyltransferase; This is an all-kingdom (but not all species) full-length ortholog enzyme for repairing aging proteins. Among the prokaryotes, the gene name is pcm. Among eukaryotes, pimt. [Protein fate, Protein modification and repair]


Pssm-ID: 272896 [Multi-domain]  Cd Length: 215  Bit Score: 319.85  E-value: 2.36e-112
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617182   1 MVSKRVQALLTQLRTQG-ITDERVLEAISQVPREKFVDEAFEHKAWENVALPIGQGQTISQPYMVARMTELLELTPESRV 79
Cdd:TIGR00080   2 DLESQKKALIDKLINEGyIKSKRVIDALLSVPREEFVPEHFKEYAYVDTPLEIGYGQTISAPHMVAMMTELLELKPGMKV 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617182  80 LEIGTGSGYQTAILAHLVHH---VCSVERIKGLQWHARRRLKQLDLHNVSTRHGDGWQGWQARAPFDAIIVTAAPLEIPA 156
Cdd:TIGR00080  82 LEIGTGSGYQAAVLAEIVGRdglVVSIERIPELAEKAERRLRKLGLDNVIVIVGDGTQGWEPLAPYDRIYVTAAGPKIPE 161

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1296617182 157 ALLAQLDDGGILVLPVGDEQQLLKRVCRRGGEFIIDTVEAVRFVPLVKGELA 208
Cdd:TIGR00080 162 ALIDQLKEGGILVMPVGEYLQVLKRAEKRGGEIIIKDVEPVAFVPLVGGEGF 213
Pcm COG2518
Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, ...
 11-205 3.56e-106

Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 442008 [Multi-domain]  Cd Length: 197  Bit Score: 303.16  E-value: 3.56e-106
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617182  11 TQLRTQGITDERVLEAISQVPREKFVDEAFEHKAWENVALPIGQGQTISQPYMVARMTELLELTPESRVLEIGTGSGYQT 90
Cdd:COG2518     2 QQLRPRGVTDPRVLDAMRAVPRELFVPEALRELAYADRALPIGHGQTISQPYIVARMLEALDLKPGDRVLEIGTGSGYQA 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617182  91 AILAHLVHHVCSVERIKGLQWHARRRLKQLDLHNVSTRHGDGWQGWQARAPFDAIIVTAAPLEIPAALLAQLDDGGILVL 170
Cdd:COG2518    82 AVLARLAGRVYSVERDPELAERARERLAALGYDNVTVRVGDGALGWPEHAPFDRIIVTAAAPEVPEALLEQLAPGGRLVA 161

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 1296617182 171 PVGDE-QQLLKRVCRRGGEFIIDTVEAVRFVPLVKG 205
Cdd:COG2518   162 PVGEGgVQRLVLITRTGDGFERESLFEVRFVPLRGG 197
PCMT pfam01135
Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT);
5-202 2.17e-95

Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT);


Pssm-ID: 395902 [Multi-domain]  Cd Length: 205  Bit Score: 276.56  E-value: 2.17e-95
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617182   5 RVQALLTQLRTQG-ITDERVLEAISQVPREKFVDEAFEHKAWENVALPIGQGQTISQPYMVARMTELLELTPESRVLEIG 83
Cdd:pfam01135   2 RNEALIENLKNYGvIKSDKVAEAMLAVDREEFVPESFKSYAYEDIPLSIGYGQTISAPHMHAMMLELLELKPGMRVLEIG 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617182  84 TGSGYQTAILAHLVHHVC---SVERIKGLQWHARRRLKQLDLHNVSTRHGDGWQGWQARAPFDAIIVTAAPLEIPAALLA 160
Cdd:pfam01135  82 SGSGYLTACFARMVGEVGrvvSIEHIPELVEIARRNLEKLGLENVIVVVGDGRQGWPEFAPYDAIHVGAAAPEIPEALID 161

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1296617182 161 QLDDGGILVLPVG-DEQQLLKRVCRRG-GEFIIDTVEAVRFVPL 202
Cdd:pfam01135 162 QLKEGGRLVIPVGpNGNQVLQQFDKRNdGSVVIKDLEGVRFVPL 205
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 78-172 4.72e-06

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 43.96  E-value: 4.72e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617182  78 RVLEIGTGSGYQTAILA-HLVHHVCSVERIKGLQWHARRRLKQLDLHNVSTRHGDGWQG-WQARAPFDAIIVTAA---PL 152
Cdd:cd02440     1 RVLDLGCGTGALALALAsGPGARVTGVDISPVALELARKAAAALLADNVEVLKGDAEELpPEADESFDVIISDPPlhhLV 80

                          90       100
                  ....*....|....*....|....
gi 1296617182 153 EIPAALLAQ----LDDGGILVLPV 172
Cdd:cd02440    81 EDLARFLEEarrlLKPGGVLVLTL 104
rADc smart00650
Ribosomal RNA adenine dimethylases;
63-146 6.12e-03

Ribosomal RNA adenine dimethylases;


Pssm-ID: 128898  Cd Length: 169  Bit Score: 35.95  E-value: 6.12e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617182   63 MVARMTELLELTPESRVLEIGTGSGYQTAILAHLVHHVCSVERIKGLQWHARRRLKqlDLHNVSTRHGDGWQGWQARAPF 142
Cdd:smart00650   1 VIDKIVRAANLRPGDTVLEIGPGKGALTEELLERAKRVTAIEIDPRLAPRLREKFA--AADNLTVIHGDALKFDLPKLQP 78


                   ....
gi 1296617182  143 DAII 146
Cdd:smart00650  79 YKVV 82
 
Name Accession Description Interval E-value
pcm PRK00312
protein-L-isoaspartate(D-aspartate) O-methyltransferase;
1-208 1.46e-132

protein-L-isoaspartate(D-aspartate) O-methyltransferase;


Pssm-ID: 178974 [Multi-domain]  Cd Length: 212  Bit Score: 370.69  E-value: 1.46e-132
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617182   1 MVSKRVQALLTQLRTQGITDERVLEAISQVPREKFVDEAFEHKAWENVALPIGQGQTISQPYMVARMTELLELTPESRVL 80
Cdd:PRK00312    4 MESERFARLVLRLRAEGILDERVLEAIEATPRELFVPEAFKHKAYENRALPIGCGQTISQPYMVARMTELLELKPGDRVL 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617182  81 EIGTGSGYQTAILAHLVHHVCSVERIKGLQWHARRRLKQLDLHNVSTRHGDGWQGWQARAPFDAIIVTAAPLEIPAALLA 160
Cdd:PRK00312   84 EIGTGSGYQAAVLAHLVRRVFSVERIKTLQWEAKRRLKQLGLHNVSVRHGDGWKGWPAYAPFDRILVTAAAPEIPRALLE 163

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 1296617182 161 QLDDGGILVLPVGDE-QQLLKRVCRRGGEFIIDTVEAVRFVPLVKGELA 208
Cdd:PRK00312  164 QLKEGGILVAPVGGEeQQLLTRVRKRGGRFEREVLEEVRFVPLVKGELA 212
pimt TIGR00080
protein-L-isoaspartate(D-aspartate) O-methyltransferase; This is an all-kingdom (but not all ...
 1-208 2.36e-112

protein-L-isoaspartate(D-aspartate) O-methyltransferase; This is an all-kingdom (but not all species) full-length ortholog enzyme for repairing aging proteins. Among the prokaryotes, the gene name is pcm. Among eukaryotes, pimt. [Protein fate, Protein modification and repair]


Pssm-ID: 272896 [Multi-domain]  Cd Length: 215  Bit Score: 319.85  E-value: 2.36e-112
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617182   1 MVSKRVQALLTQLRTQG-ITDERVLEAISQVPREKFVDEAFEHKAWENVALPIGQGQTISQPYMVARMTELLELTPESRV 79
Cdd:TIGR00080   2 DLESQKKALIDKLINEGyIKSKRVIDALLSVPREEFVPEHFKEYAYVDTPLEIGYGQTISAPHMVAMMTELLELKPGMKV 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617182  80 LEIGTGSGYQTAILAHLVHH---VCSVERIKGLQWHARRRLKQLDLHNVSTRHGDGWQGWQARAPFDAIIVTAAPLEIPA 156
Cdd:TIGR00080  82 LEIGTGSGYQAAVLAEIVGRdglVVSIERIPELAEKAERRLRKLGLDNVIVIVGDGTQGWEPLAPYDRIYVTAAGPKIPE 161

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1296617182 157 ALLAQLDDGGILVLPVGDEQQLLKRVCRRGGEFIIDTVEAVRFVPLVKGELA 208
Cdd:TIGR00080 162 ALIDQLKEGGILVMPVGEYLQVLKRAEKRGGEIIIKDVEPVAFVPLVGGEGF 213
Pcm COG2518
Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, ...
 11-205 3.56e-106

Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 442008 [Multi-domain]  Cd Length: 197  Bit Score: 303.16  E-value: 3.56e-106
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617182  11 TQLRTQGITDERVLEAISQVPREKFVDEAFEHKAWENVALPIGQGQTISQPYMVARMTELLELTPESRVLEIGTGSGYQT 90
Cdd:COG2518     2 QQLRPRGVTDPRVLDAMRAVPRELFVPEALRELAYADRALPIGHGQTISQPYIVARMLEALDLKPGDRVLEIGTGSGYQA 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617182  91 AILAHLVHHVCSVERIKGLQWHARRRLKQLDLHNVSTRHGDGWQGWQARAPFDAIIVTAAPLEIPAALLAQLDDGGILVL 170
Cdd:COG2518    82 AVLARLAGRVYSVERDPELAERARERLAALGYDNVTVRVGDGALGWPEHAPFDRIIVTAAAPEVPEALLEQLAPGGRLVA 161

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 1296617182 171 PVGDE-QQLLKRVCRRGGEFIIDTVEAVRFVPLVKG 205
Cdd:COG2518   162 PVGEGgVQRLVLITRTGDGFERESLFEVRFVPLRGG 197
PCMT pfam01135
Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT);
5-202 2.17e-95

Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT);


Pssm-ID: 395902 [Multi-domain]  Cd Length: 205  Bit Score: 276.56  E-value: 2.17e-95
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617182   5 RVQALLTQLRTQG-ITDERVLEAISQVPREKFVDEAFEHKAWENVALPIGQGQTISQPYMVARMTELLELTPESRVLEIG 83
Cdd:pfam01135   2 RNEALIENLKNYGvIKSDKVAEAMLAVDREEFVPESFKSYAYEDIPLSIGYGQTISAPHMHAMMLELLELKPGMRVLEIG 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617182  84 TGSGYQTAILAHLVHHVC---SVERIKGLQWHARRRLKQLDLHNVSTRHGDGWQGWQARAPFDAIIVTAAPLEIPAALLA 160
Cdd:pfam01135  82 SGSGYLTACFARMVGEVGrvvSIEHIPELVEIARRNLEKLGLENVIVVVGDGRQGWPEFAPYDAIHVGAAAPEIPEALID 161

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1296617182 161 QLDDGGILVLPVG-DEQQLLKRVCRRG-GEFIIDTVEAVRFVPL 202
Cdd:pfam01135 162 QLKEGGRLVIPVGpNGNQVLQQFDKRNdGSVVIKDLEGVRFVPL 205
PRK13942 PRK13942
protein-L-isoaspartate O-methyltransferase; Provisional
 1-203 1.33e-64

protein-L-isoaspartate O-methyltransferase; Provisional


Pssm-ID: 184409  Cd Length: 212  Bit Score: 198.70  E-value: 1.33e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617182   1 MVSKRVQALLTQLRTQG-ITDERVLEAISQVPREKFVDEAFEHKAWENVALPIGQGQTISQPYMVARMTELLELTPESRV 79
Cdd:PRK13942    1 MPLEEKRRVIEELIREGyIKSKKVIDALLKVPRHLFVPEYLEEYAYVDTPLEIGYGQTISAIHMVAIMCELLDLKEGMKV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617182  80 LEIGTGSGYQTAILAHLV---HHVCSVERIKGLQWHARRRLKQLDLHNVSTRHGDGWQGWQARAPFDAIIVTAAPLEIPA 156
Cdd:PRK13942   81 LEIGTGSGYHAAVVAEIVgksGKVVTIERIPELAEKAKKTLKKLGYDNVEVIVGDGTLGYEENAPYDRIYVTAAGPDIPK 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 1296617182 157 ALLAQLDDGGILVLPVGDEQQLLKRVCRRGGEFIIDTVEAVRFVPLV 203
Cdd:PRK13942  161 PLIEQLKDGGIMVIPVGSYSQELIRVEKDNGKIIKKKLGEVAFVPLI 207
PRK13944 PRK13944
protein-L-isoaspartate O-methyltransferase; Provisional
 9-202 8.09e-45

protein-L-isoaspartate O-methyltransferase; Provisional


Pssm-ID: 140001  Cd Length: 205  Bit Score: 148.04  E-value: 8.09e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617182   9 LLTQLRTQG-ITDERVLEAISQVPREKFVDEAFEHKAWENVALPIGQGQTISQPYMVARMTELLELTPESRVLEIGTGSG 87
Cdd:PRK13944    5 LVEELVREGiIKSERVKKAMLSVPREEFVMPEYRMMAYEDRPLPLFAGATISAPHMVAMMCELIEPRPGMKILEVGTGSG 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617182  88 YQTAILAHLVHH---VCSVERIKGLQWHARRRLKQLDLHN-VSTRHGDGWQGWQARAPFDAIIVTAAPLEIPAALLAQLD 163
Cdd:PRK13944   85 YQAAVCAEAIERrgkVYTVEIVKELAIYAAQNIERLGYWGvVEVYHGDGKRGLEKHAPFDAIIVTAAASTIPSALVRQLK 164

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1296617182 164 DGGILVLPVGDE-QQLLKRVCRRGGEFIIDTVEAVRFVPL 202
Cdd:PRK13944  165 DGGVLVIPVEEGvGQVLYKVVKRGEKVEKRAITYVLFVPL 204
PRK13943 PRK13943
protein-L-isoaspartate O-methyltransferase; Provisional
 13-172 5.60e-24

protein-L-isoaspartate O-methyltransferase; Provisional


Pssm-ID: 237568 [Multi-domain]  Cd Length: 322  Bit Score: 96.45  E-value: 5.60e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617182  13 LRTQGITDeRVLEAISQVPREKFVDEAFEHK-AWENVALPIGQGQ----TISQPYMVARMTELLELTPESRVLEIGTGSG 87
Cdd:PRK13943   14 LKKYGISD-HIAKAFLEVPREEFLTKSYPLSyVYEDIVLVSYDDGeeysTSSQPSLMALFMEWVGLDKGMRVLEIGGGTG 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617182  88 YQTAILAHLVHH---VCSVERIKGLQWHARRRLKQLDLHNVSTRHGDGWQGWQARAPFDAIIVTAAPLEIPAALLAQLDD 164
Cdd:PRK13943   93 YNAAVMSRVVGEkglVVSVEYSRKICEIAKRNVRRLGIENVIFVCGDGYYGVPEFAPYDVIFVTVGVDEVPETWFTQLKE 172


                  ....*...
gi 1296617182 165 GGILVLPV 172
Cdd:PRK13943  173 GGRVIVPI 180
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 65-191 7.01e-10

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 55.00  E-value: 7.01e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617182  65 ARMTELLELTPESRVLEIGTGSGYQTAILAHLVHHVCSVERIKGLQWHARRRLKQLDLhNVSTRHGDGWQGWQARAPFDA 144
Cdd:COG2226    12 EALLAALGLRPGARVLDLGCGTGRLALALAERGARVTGVDISPEMLELARERAAEAGL-NVEFVVGDAEDLPFPDGSFDL 90

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1296617182 145 IIVTAAPLEIP--AALLAQlddggilvlpvgdeqqlLKRVCRRGGEFII 191
Cdd:COG2226    91 VISSFVLHHLPdpERALAE-----------------IARVLKPGGRLVV 122
Gcd14 COG2519
tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 ...
 62-147 2.02e-08

tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 N-methylase Trm61 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 442009 [Multi-domain]  Cd Length: 249  Bit Score: 52.85  E-value: 2.02e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617182  62 YMVARmtelLELTPESRVLEIGTGSGYQTAILAHLVH---HVCSVERIKGLQWHARRRLKQLDLH-NVSTRHGDGWQGWQ 137
Cdd:COG2519    82 YIIAR----LDIFPGARVLEAGTGSGALTLALARAVGpegKVYSYERREDFAEIARKNLERFGLPdNVELKLGDIREGID 157

                          90
                  ....*....|
gi 1296617182 138 ARaPFDAIIV 147
Cdd:COG2519   158 EG-DVDAVFL 166
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 60-170 4.55e-08

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 50.31  E-value: 4.55e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617182  60 QPYMVARMTELLELTPESRVLEIGTGSGYQTAILA-HLVHHVCSVERIKGLQWHARRRLKQLDLHN-VSTRHGDgWQGWQ 137
Cdd:COG2230    36 QEAKLDLILRKLGLKPGMRVLDIGCGWGGLALYLArRYGVRVTGVTLSPEQLEYARERAAEAGLADrVEVRLAD-YRDLP 114

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1296617182 138 ARAPFDAII----VTAAPLEIPAALLAQ----LDDGGILVL 170
Cdd:COG2230   115 ADGQFDAIVsigmFEHVGPENYPAYFAKvarlLKPGGRLLL 155
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 65-170 5.28e-08

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 49.63  E-value: 5.28e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617182  65 ARMTELLE--LTPESRVLEIGTGSGYQTAILAHLVHHVCSVERIKGLQWHARRRLKQLdlhNVSTRHGDGWQGWQARAPF 142
Cdd:COG2227    12 RRLAALLArlLPAGGRVLDVGCGTGRLALALARRGADVTGVDISPEALEIARERAAEL---NVDFVQGDLEDLPLEDGSF 88

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1296617182 143 DAIIVTAA------PLEIPAALLAQLDDGGILVL 170
Cdd:COG2227    89 DLVICSEVlehlpdPAALLRELARLLKPGGLLLL 122
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 60-199 1.27e-07

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 49.91  E-value: 1.27e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617182  60 QPYMVARMTELLELTPESRVLEIGTGSGYQTAILA-HLVHHVC----SVERIKglqwHARRRLKQLDLHNVSTRHGDgWQ 134
Cdd:COG0500    11 LPGLAALLALLERLPKGGRVLDLGCGTGRNLLALAaRFGGRVIgidlSPEAIA----LARARAAKAGLGNVEFLVAD-LA 85

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1296617182 135 GWQAR--APFDAIIVTAA----PLEIPAALLA----QLDDGGILVLpVGDEQQLLKRVCRRGGEFIIDTVEAVRF 199
Cdd:COG0500    86 ELDPLpaESFDLVVAFGVlhhlPPEEREALLRelarALKPGGVLLL-SASDAAAALSLARLLLLATASLLELLLL 159
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
75-170 3.56e-06

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 44.04  E-value: 3.56e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617182  75 PESRVLEIGTGSGYQTAILAHLV--HHVCSVERIKGLQWHARRRLKqldlhNVSTRHGDGWQgWQARAPFDAIIVTAA-- 150
Cdd:COG4106     1 PPRRVLDLGCGTGRLTALLAERFpgARVTGVDLSPEMLARARARLP-----NVRFVVADLRD-LDPPEPFDLVVSNAAlh 74

                          90       100
                  ....*....|....*....|....
gi 1296617182 151 ----PLEIPAALLAQLDDGGILVL 170
Cdd:COG4106    75 wlpdHAALLARLAAALAPGGVLAV 98
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 79-187 3.87e-06

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 43.71  E-value: 3.87e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617182  79 VLEIGTGSGYQTAILAHLV-HHVCSVERIKGLQWHARRRLKQLDLhNVSTRHGDGWQGWQARAPFDAIIVTAApleipaa 157
Cdd:pfam13649   1 VLDLGCGTGRLTLALARRGgARVTGVDLSPEMLERARERAAEAGL-NVEFVQGDAEDLPFPDGSFDLVVSSGV------- 72

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1296617182 158 llaqlddggILVLPVGDEQQLLK---RVCRRGG 187
Cdd:pfam13649  73 ---------LHHLPDPDLEAALReiaRVLKPGG 96
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 78-172 4.72e-06

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 43.96  E-value: 4.72e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617182  78 RVLEIGTGSGYQTAILA-HLVHHVCSVERIKGLQWHARRRLKQLDLHNVSTRHGDGWQG-WQARAPFDAIIVTAA---PL 152
Cdd:cd02440     1 RVLDLGCGTGALALALAsGPGARVTGVDISPVALELARKAAAALLADNVEVLKGDAEELpPEADESFDVIISDPPlhhLV 80

                          90       100
                  ....*....|....*....|....
gi 1296617182 153 EIPAALLAQ----LDDGGILVLPV 172
Cdd:cd02440    81 EDLARFLEEarrlLKPGGVLVLTL 104
HemK COG2890
Methylase of polypeptide chain release factors [Translation, ribosomal structure and ...
 63-176 1.03e-04

Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis];


Pssm-ID: 442135 [Multi-domain]  Cd Length: 282  Bit Score: 42.06  E-value: 1.03e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617182  63 MVARMTELLELTPESRVLEIGTGSGyqtAI---LAHLVH--HVCSVERIKG-LQWhARRRLKQLDLHN-VSTRHGDGWQG 135
Cdd:COG2890   100 LVELALALLPAGAPPRVLDLGTGSG---AIalaLAKERPdaRVTAVDISPDaLAV-ARRNAERLGLEDrVRFLQGDLFEP 175

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1296617182 136 WQARAPFDAII-----VTAA-----------------------PLEIPAALLAQ----LDDGGILVLPVGDEQ 176
Cdd:COG2890   176 LPGDGRFDLIVsnppyIPEDeiallppevrdheprlaldggedGLDFYRRIIAQaprlLKPGGWLLLEIGEDQ 248
ksgA PRK14896
16S ribosomal RNA methyltransferase A;
64-131 2.19e-04

16S ribosomal RNA methyltransferase A;


Pssm-ID: 237852 [Multi-domain]  Cd Length: 258  Bit Score: 41.04  E-value: 2.19e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1296617182  64 VARMTELLELTPESRVLEIGTGSGYQTAILAHLVHHVCSVERIKGLQWHARRRLKQLDlhNVSTRHGD 131
Cdd:PRK14896   18 VDRIVEYAEDTDGDPVLEIGPGKGALTDELAKRAKKVYAIELDPRLAEFLRDDEIAAG--NVEIIEGD 83
RrnaAD pfam00398
Ribosomal RNA adenine dimethylase;
61-181 6.20e-04

Ribosomal RNA adenine dimethylase;


Pssm-ID: 395321 [Multi-domain]  Cd Length: 263  Bit Score: 39.66  E-value: 6.20e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617182  61 PYMVARMTELLELTPESRVLEIGTGSGYQTAILAHLVHHVCSVERIKGLQWHARRRLkqLDLHNVSTRHGDGWQgWQ--- 137
Cdd:pfam00398  16 PKVINEIVDKANLRESDTVLEIGPGKGALTVILAKRAKQVVAIEIDPRLAKLLQKKL--SLDENLTVIHQDFLK-FEfps 92

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1296617182 138 --ARAPFDAIIVTAAPLEIPAALLAQLDD-------GGILVLPVGDEQQLLKR 181
Cdd:pfam00398  93 lvTHIHQEFLVVGNLPYNISTPIVKQLLFesrfgivDMLLMLQKEFARRLLAR 145
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 73-201 1.45e-03

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 37.78  E-value: 1.45e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617182  73 LTPESRVLEIGTGSGYQTAILAHLVH---HVCSVERIKGLQWHARRRLKQLDLHNVSTRHGD--GWQGWQARAPFDAIIv 147
Cdd:pfam13847   1 IDKGMRVLDLGCGTGHLSFELAEELGpnaEVVGIDISEEAIEKARENAQKLGFDNVEFEQGDieELPELLEDDKFDVVI- 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1296617182 148 taapleIPAALLAQLDDGGILvlpvgdeqQLLKRVCRRGGEFIIDTVEAVRFVP 201
Cdd:pfam13847  80 ------SNCVLNHIPDPDKVL--------QEILRVLKPGGRLIISDPDSLAELP 119
RsmA COG0030
16S rRNA A1518 and A1519 N6-dimethyltransferase RsmA/KsgA/DIM1 (may also have DNA glycosylase ...
 64-131 3.01e-03

16S rRNA A1518 and A1519 N6-dimethyltransferase RsmA/KsgA/DIM1 (may also have DNA glycosylase/AP lyase activity) [Translation, ribosomal structure and biogenesis]; 16S rRNA A1518 and A1519 N6-dimethyltransferase RsmA/KsgA/DIM1 (may also have DNA glycosylase/AP lyase activity) is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 439801 [Multi-domain]  Cd Length: 270  Bit Score: 37.41  E-value: 3.01e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1296617182  64 VARMTELLELTPESRVLEIGTGSGYQTAILAHLVHHVCSVERIKGLQWHARRRLKQLDlhNVSTRHGD 131
Cdd:COG0030    26 IRRIVDAAGITPGDTVLEIGPGLGALTRALLERAARVTAVEIDRRLAAILRETFAAYP--NLTVIEGD 91
TrmR COG4122
tRNA 5-hydroxyU34 O-methylase TrmR/YrrM [Translation, ribosomal structure and biogenesis]; ...
 78-170 4.10e-03

tRNA 5-hydroxyU34 O-methylase TrmR/YrrM [Translation, ribosomal structure and biogenesis]; tRNA 5-hydroxyU34 O-methylase TrmR/YrrM is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443298  Cd Length: 173  Bit Score: 36.70  E-value: 4.10e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617182  78 RVLEIGTGSGYQTAILA-------HLVhhvcSVERIKGLQWHARRRLKQLDL-HNVSTRHGDgwqgwqAR--------AP 141
Cdd:COG4122    19 RILEIGTGTGYSTLWLAralpddgRLT----TIEIDPERAAIARENFARAGLaDRIRLILGD------ALevlprladGP 88

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1296617182 142 FDAIIVTAAPLEIPAAL---LAQLDDGGILVL 170
Cdd:COG4122    89 FDLVFIDADKSNYPDYLelaLPLLRPGGLIVA 120
rADc smart00650
Ribosomal RNA adenine dimethylases;
63-146 6.12e-03

Ribosomal RNA adenine dimethylases;


Pssm-ID: 128898  Cd Length: 169  Bit Score: 35.95  E-value: 6.12e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617182   63 MVARMTELLELTPESRVLEIGTGSGYQTAILAHLVHHVCSVERIKGLQWHARRRLKqlDLHNVSTRHGDGWQGWQARAPF 142
Cdd:smart00650   1 VIDKIVRAANLRPGDTVLEIGPGKGALTEELLERAKRVTAIEIDPRLAPRLREKFA--AADNLTVIHGDALKFDLPKLQP 78


                   ....
gi 1296617182  143 DAII 146
Cdd:smart00650  79 YKVV 82
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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