|
Name |
Accession |
Description |
Interval |
E-value |
| EmrB |
NF000391 |
multidrug efflux MFS transporter permease subunit EmrB; |
4-502 |
0e+00 |
|
multidrug efflux MFS transporter permease subunit EmrB;
Pssm-ID: 411083 [Multi-domain] Cd Length: 501 Bit Score: 993.07 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 4 QKPLEGAQLVIMTIALSLATFMQVLDSTIANVAIPTIAGNLGSSLSQGTWVITSFGVANAISIPITGWLAKRVGEVRLFL 83
Cdd:NF000391 1 RKPLEGAQLAWMTIALSLATFMQVLDSTIANVAIPTIAGNLGASNSQGTWVITSFGVANAISIPITGWLAKRIGEVKLFL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 84 WSTVLFVIASWACGMSNSLTMLIFFRVIQGIVAGPLIPLSQSLLLNNYPPAKRSIALALWSMTVIVAPICGPILGGYISD 163
Cdd:NF000391 81 WSTALFALASWLCGISNSLGMLIFFRVIQGLVAGPLIPLSQSLLLNNYPPAKRSMALALWSMTVIVAPICGPILGGYISD 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 164 NYHWGWIFFINVPIGALVVLMTLQSLRGRETKTEQRRIDGVGLALLVLGIGSLQIMLDRGKELDWFASQEIIVLTVVAVV 243
Cdd:NF000391 161 NYHWGWIFFINVPIGIAVVLLTLQTLRGRETKTEIRPIDTVGLVLLVVGIGSLQIMLDQGKELDWFNSTEIIVLTVVAVV 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 244 AISFLIVWELTDDNPIVDLSLFKSRNFTIGCLCISLAYMLYFGAIVLLPQLLQEVYGYTATWAGLASAPVGLIPVLLSPI 323
Cdd:NF000391 241 ALSFLIVWELTDDHPIVDLSLFKSRNFTIGCLCISLAYMLYFGAIVLLPQLLQEVYGYTATWAGLASAPVGLIPVLLSPI 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 324 IGRFAHKLDMRRLVTFSFIMYAVCFYWRAYTFEPGMDFGASAWPQFIQGFAVACFFMPLTTITLSGLPPERMAAASSLSN 403
Cdd:NF000391 321 IGRFGHKLDMRRLVTFSFIMYAVCFYWRAYTFEPGMDFGASAWPQFIQGFAVACFFMPLTTITLSGLPPERMAAASSLSN 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 404 FTRTLAGSIGTSITTTLWTNRESLHHAQLTESVNPFNPNAQQMYSELQSMGMTEQQASGWIAQQITNQGLIISANEIFWI 483
Cdd:NF000391 401 FTRTLAGSIGTSITTTLWTQRESMHHSQLTESINPYNPNAQQMYQQLEQLGMSQQQASAYIAQQITNQGLIISANEIFWL 480
|
490
....*....|....*....
gi 1296617283 484 SAGIFILLLGLIWFAKPPF 502
Cdd:NF000391 481 SAGVFLILLVLVWFAKPPF 499
|
|
| efflux_EmrB |
TIGR00711 |
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ... |
13-498 |
0e+00 |
|
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]
Pssm-ID: 129794 [Multi-domain] Cd Length: 485 Bit Score: 645.97 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 13 VIMTIALSLATFMQVLDSTIANVAIPTIAGNLGSSLSQGTWVITSFGVANAISIPITGWLAKRVGEVRLFLWSTVLFVIA 92
Cdd:TIGR00711 1 LLLTIVLMLGTFMAVLDSTIVNVAIPTIAGDLGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 93 SWACGMSNSLTMLIFFRVIQGIVAGPLIPLSQSLLLNNYPPAKRSIALALWSMTVIVAPICGPILGGYISDNYHWGWIFF 172
Cdd:TIGR00711 81 SLLCGVAPNLELMIIFRVIQGFGGGPLIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENYHWRWIFL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 173 INVPIGALVVLMTLQSLRgRETKTEQRRIDGVGLALLVLGIGSLQIMLDRGKELDWFASQEIIVLTVVAVVAISFLIVWE 252
Cdd:TIGR00711 161 INVPIGIIVVVVAFFILP-RDKPAASENFDFLGLLLLSVGLGSLLYGLSEGPERGWFDSNEILILSITGLVAIIAFVVWE 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 253 LTDDNPIVDLSLFKSRNFTIGCLCISLAYMLYFGAIVLLPQLLQEVYGYTATWAGLASAPVGLIPVLLSPIIGRFAHKLD 332
Cdd:TIGR00711 240 LTDDNPLVDLRLFKYRNFTIGCVYMSLLGLGLYGSFYLLPLYLQQVLGYTALQAGLHILPVGLAPMLSSPIAGRMGDKID 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 333 MRRLVTFSFIMYAVCFYWRAYTFEPGMDFGASAWPQFIQGFAVACFFMPLTTITLSGLPPERMAAASSLSNFTRTLAGSI 412
Cdd:TIGR00711 320 PRKLVTIGLILYAVGFYWRAFTFTPDTPFLAIALPQFIRGFGMGCFFMPLTTIALSGLPPHKIARGSSLSNFTRQLGGSI 399
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 413 GTSITTTLWTNRESLHHAQLTESVNPFNPNAQQMYSELQSMGMTEQQASGWIAQQITNQGLIISANEIFWISAGIFILLL 492
Cdd:TIGR00711 400 GTALITTILTNRTQFHHSQLTETINPVNPNFLSGYSQLAALGNPEQQVYALIAQQITLHAFSIAINEIFWMATLLFVSGL 479
|
....*.
gi 1296617283 493 GLIWFA 498
Cdd:TIGR00711 480 ILIWFL 485
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
19-499 |
5.43e-123 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 364.98 E-value: 5.43e-123
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 19 LSLATFMQVLDSTIANVAIPTIAGNLGSSLSQGTWVITSFGVANAISIPITGWLAKRVGEVRLFLWSTVLFVIASWACGM 98
Cdd:cd17503 1 LLLGAFMAILDTTIVNVALPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 99 SNSLTMLIFFRVIQGIVAGPLIPLSQSLLLNNYPPAKRSIALALWSMTVIVAPICGPILGGYISDNYHWGWIFFINVPIG 178
Cdd:cd17503 81 APNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPIG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 179 ALVVLMTlqslrgretkteqrridgvglallvlgigslqimldrgkeldwfasqeiivltvvavvaisflivweltddnP 258
Cdd:cd17503 161 ILALLLA------------------------------------------------------------------------P 168
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 259 IVDLSLFKSRNFTIGCLCISLAYMLYFGAIVLLPQLLQEVYGYTATWAGLASAPVGLIPVLLSPIIGRFAHKLDMRRLVT 338
Cdd:cd17503 169 LLDLRLFKDRNFTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLL 248
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 339 FSFIMYAVCFYWRAYtFEPGMDFGASAWPQFIQGFAVACFFMPLTTITLSGLPPERMAAASSLSNFTRTLAGSIGTSITT 418
Cdd:cd17503 249 AGLLLLALGTLLLAF-LTPDTSLWLIILPLFIRGLGMGLVFMPLNTLALNSLPPEQIGDATALFNTIRQLGGSIGTALLA 327
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 419 TLWTNRESLHHAQLTEsvnpfnpnaqqmyselqsmgmteqqasgWIAQQITNQGLIISANEIFWISAGIFILLLGLIWFA 498
Cdd:cd17503 328 TLLTNRTQFHHSRLSE----------------------------LLAQQVQKQALIIAFNDAFLVSAILLLVGLLLALFL 379
|
.
gi 1296617283 499 K 499
Cdd:cd17503 380 R 380
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
19-428 |
2.06e-63 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 210.88 E-value: 2.06e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 19 LSLATFMQVLDSTIANVAIPTIAGNLGSSLSQGTWVITSFGVANAISIPITGWLAKRVGEVRLFLWSTVLFVIASWACGM 98
Cdd:cd17321 1 LLLAVFLAALDVTIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 99 SNSLTMLIFFRVIQGIVAGPLIPLSQSLLLNNYPPAKRSIALALWSMTVIVAPICGPILGGYISDNYHWGWIFFINVPIG 178
Cdd:cd17321 81 APSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 179 ALVVLMTlqslrgretkteqrridgvglallvlgigslqimldrgkeldwfasqeiivltvvavvaisflivweltddnp 258
Cdd:cd17321 161 LVALLLA------------------------------------------------------------------------- 167
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 259 ivdlslfksRNFTIGCLCISLAYMLYFGAIVLLPQLLQEVYGYTATWAGLASAPVGLIPVLLSPIIGRFAHKLDMRRLVT 338
Cdd:cd17321 168 ---------RTFSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLV 238
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 339 FSFIMYAVCFYWRAYTFePGMDFGASAWPQFIQGFAVACFFMPLTTITLSGLPPERMAAASSLSNFTRTLAGSIGTSITT 418
Cdd:cd17321 239 AGLLLTAVGLLLLALLG-ADSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGALGVALLG 317
|
410
....*....|
gi 1296617283 419 TLWTNRESLH 428
Cdd:cd17321 318 ALLTAGLSAN 327
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
19-423 |
1.77e-49 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 173.13 E-value: 1.77e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 19 LSLATFMQVLDSTIANVAIPTIAGNLGSsLSQGTWVITSFGVANAISIPITGWLAKRVGEVRLFLWSTVLFVIASWACGM 98
Cdd:cd17502 1 LMLALFLAALDQTIVATALPTIVAEFGG-LSLVSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 99 SNSLTMLIFFRVIQGIVAGPLIPLSQSLLLNNYPPAKRSIALALWSMTVIVAPICGPILGGYISDNYHWGWIFFINVPIG 178
Cdd:cd17502 80 APNMTMLIVGRAIQGIGGGGLMSLAFIIIADLVPPRERGKYQGYIGAVFGIASVAGPLIGGAFTDHLSWRWCFYINLPIG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 179 Alvvlmtlqslrgretkteqrridgvglallvlgigslqimldrgkeldwfasqeiivltvvavvaisflivweltddnp 258
Cdd:cd17502 160 G------------------------------------------------------------------------------- 160
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 259 ivdLSLFKSRNFTIGCLCISLAYMLYFGAIVLLPQLLQEVYGYTATWAGLASAPVGLIPVLLSPIIGRFAHKL-DMRRLV 337
Cdd:cd17502 161 ---LALALLRTILLSSIFGFLFGGALFGLIYYLPLYFQLVLGDSATKSGVRLLPLIIGLVIGSIISGALISKTgRYKPLI 237
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 338 TFSFIMYAVCFYWrAYTFEPGMDFGASAWPQFIQGFAVACFFMPLTTITLSGLPPERMAAASSLSNFTRTLAGSIGTSIT 417
Cdd:cd17502 238 VIGTILMSVGAGL-LTTLTLDTSKWLLIGYLILLGLGLGIGFQQPLVAVQNAVPPADVGVATATNTFFRSLGGTLGVAIT 316
|
....*.
gi 1296617283 418 TTLWTN 423
Cdd:cd17502 317 DVFLVA 322
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
14-412 |
5.10e-49 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 172.08 E-value: 5.10e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 14 IMTIALSLATFMQVLDSTIANVAIPTIAGNLGSSLSQGTWVITSFGVANAISIPITGWLAKRVGEVRLFLWSTVLFVIAS 93
Cdd:COG2814 10 LALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGS 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 94 WACGMSNSLTMLIFFRVIQGIVAGPLIPLSQSLLLNNYPPAKRSIALALWSMTVIVAPICGPILGGYISDNYHWGWIFFI 173
Cdd:COG2814 90 LLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLV 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 174 NVPIGALVVLMTLQSLRGRETKTEQRRIDGVglallvlgigslqimldrgkeldwfasqeiivltvvavvaisflivwel 253
Cdd:COG2814 170 NAVLALLALLLLLRLLPESRPAARARLRGSL------------------------------------------------- 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 254 tddnpivdLSLFKSRNFTIGCLCISLAYMLYFGAIVLLPQLLQEVYGYTATWAGLASAPVGLIPVLLSPIIGRFAHKLDM 333
Cdd:COG2814 201 --------RELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGR 272
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1296617283 334 RRLVTFSFIMYAVCFYWRAYTFEPGMDFGASawpqFIQGFAVACFFMPLTTITLSGLPPERMAAASSLSNFTRTLAGSI 412
Cdd:COG2814 273 RRLLLIGLLLLALGLLLLALAGSLWLLLLAL----FLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPL 347
|
|
| PRK10504 |
PRK10504 |
putative transporter; Provisional |
24-416 |
5.35e-39 |
|
putative transporter; Provisional
Pssm-ID: 182502 [Multi-domain] Cd Length: 471 Bit Score: 147.96 E-value: 5.35e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 24 FMQVLDSTIANVAIPTIAGNLGSSLSQGTWVITSFGVANAISIPITGWLAKRVGEVRLFLWSTVLFVIASWACGMSNSLT 103
Cdd:PRK10504 20 FMQSLDTTIVNTALPSMAQSLGESPLHMHMVIVSYVLTVAVMLPASGWLADRVGVRNIFFTAIVLFTLGSLFCALSGTLN 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 104 MLIFFRVIQGIVAGPLIPLSQSLLLNNYPPAKRSIALALWSMTVIVAPICGPILGGYISDNYHWGWIFFINVPIGALVVL 183
Cdd:PRK10504 100 ELLLARVLQGVGGAMMVPVGRLTVMKIVPREQYMAAMTFVTLPGQVGPLLGPALGGLLVEYASWHWIFLINIPVGIIGAI 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 184 MTLQSLRGRETKTeqRRIDGVGLALLVLGIGSLQIMLDRGKELDwFASQEIIVLTVVAVVAISFLIVWELTDDNPIVDLS 263
Cdd:PRK10504 180 ATLMLMPNYTMQT--RRFDLSGFLLLAVGMATLTLALDGSKGLG-LSPLAIAGLVAVGVVALLLYLLHARNNNRALFSLK 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 264 LFKSRNFTIGCLCISLAY----MLYFgaivLLPQLLQEVYGYTATWAGLASAPVGLIPVLLSPIIGRFAHKLDMRRLVTF 339
Cdd:PRK10504 257 LFRTRTFSLGLAGSFAGRigsgMLPF----MTPVFLQIGLGFSPFHAGLMMIPMVLGSMGMKRIVVQVVNRFGYRRVLVA 332
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1296617283 340 SFIMYAVCFYWRAYTFEPGMDFgASAWPQFIQGFAVACFFMPLTTITLSGLPPERMAAASSLSNFTRTLAGSIGTSI 416
Cdd:PRK10504 333 TTLGLALVSLLFMLVALLGWYY-LLPFVLFLQGMVNSTRFSSMNTLTLKDLPDNLASSGNSLLSMIMQLSMSIGVTI 408
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
19-423 |
8.00e-36 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 136.94 E-value: 8.00e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 19 LSLATFMQVLDSTIANVAIPTIAGNLGSSLSQGTWVITSFGVANAISIPITGWLAKRVGEVRLFLWSTVLFVIASWACGM 98
Cdd:cd17504 1 LALAALAVMLVETMLSPALPTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 99 SNSLTMLIFFRVIQGIvAGPLIPLSQSLLLNNYPPAKRSIALALWSMTVIVAPICGPILGGYISDNYHWGWIFFINVPIG 178
Cdd:cd17504 81 APNLPVLIAGRALQGI-GGAVFPLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 179 ALVVLMTlqslrgretkteqrridgvglallvlgigslqimldrgkeldwfasqeiivltvvavvaisflivweltddnP 258
Cdd:cd17504 160 VLLAALV------------------------------------------------------------------------P 167
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 259 IVDLSLFKSRNFTIGCLCISLAYMLYFGAIVLLPQLLQE----VYGYTATWAGLASAPVGLIPVLLSPIIGRFAHKLDMR 334
Cdd:cd17504 168 LIDLRLLRRRNVLLANITALLAGFGMFMVFQLLPQLLQLptptGFGLGITEAGLLLLPGALVMLIAGPLAGRLIARVGPR 247
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 335 RLVTFSFIMYAVCFYWRAYTfepGMDFGASAWPQFIQGFAVACFFMPLTTITLSGLPPERMAAASSLSNFTRTLAGSIGT 414
Cdd:cd17504 248 RVLLIGLVISAVGLLLLALL---HSSLWALVVALLLIGIGLGLAFASLPNIVVESVPPDRTGIATGMNTVLRTIGSAIGP 324
|
....*....
gi 1296617283 415 SITTTLWTN 423
Cdd:cd17504 325 AIAGAILTT 333
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
1-251 |
4.41e-35 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 133.01 E-value: 4.41e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 1 MQQQKPLEGAQLVIMTIALSLATFMQVLDSTIANVAIPTIAGNLGSSLSQGTWVITSFGVANAISIPITGWLAKRVGEVR 80
Cdd:COG0477 1 MSSTDAAPTRRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 81 LFLWSTVLFVIASWACGMSNSLTMLIFFRVIQGIVAGPLIPLSQSLLLNNYPPAKRSIALALWSMTVIVAPICGPILGGY 160
Cdd:COG0477 81 VLLIGLLLFGLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 161 ISDNYHWGWIFFINVPIGALVVLMTLQSLRGRETKTEQRRIDGVGLALLVLGIGSLQIMLDRGKELDWFASQEIIVLTVV 240
Cdd:COG0477 161 LVAALGWRWIFLINAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALL 240
|
250
....*....|.
gi 1296617283 241 AVVAISFLIVW 251
Cdd:COG0477 241 LLLALLLLALL 251
|
|
| PRK14995 |
PRK14995 |
SmvA family efflux MFS transporter; |
28-500 |
5.40e-34 |
|
SmvA family efflux MFS transporter;
Pssm-ID: 184957 [Multi-domain] Cd Length: 495 Bit Score: 134.08 E-value: 5.40e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 28 LDSTIANVAIPTIAGNLGSSLSQGTWVITSFGVANAISIPITGWLAKRVGEVRLFLWSTVLFVIASWACGMSNSLTMLIF 107
Cdd:PRK14995 20 IDATVLHVAAPTLSMTLGASGNELLWIIDIYSLVMAGMVLPMGALGDRIGFKRLLMLGGTLFGLASLAAAFSPTASWLIA 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 108 FRVIQGIVAGPLIPLSQSLLLNNYPPAK-RSIALALWSMTVIVAPICGPILGGYISDNYHWGWIFFINVPIGALVVLMTL 186
Cdd:PRK14995 100 TRALLAIGAAMIVPATLAGIRATFTEEKqRNMALGVWAAVGSGGAAFGPLVGGILLEHFYWGSVFLINVPIVLVVMGLTA 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 187 QSLRGRETKTEQRRidGVGLAlLVLGIGSLQIMLDRGKELDWFASQEIIVLTVVAVVAISFLIV-WELTDDNPIVDLSLF 265
Cdd:PRK14995 180 RYVPRQAGRRDQPL--NLGHA-LMLIVAILLLVYSAKTALKGFLSLWVTSLTLLTGALLLGLFIrTQLAASRPMIDMRLF 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 266 KSRNFTIGCLCISLAYMLYFGAIVLLPQLLQEVYGYTATWAGLASAPVGLIPVLLSPIIGRFAHKLDMRRLVTFSFIMYA 345
Cdd:PRK14995 257 THRIILSGVVMAMTAMITLVGFELLMAQELQFVHGLSPLEAGMFMLPVMVASGFSGPIAGILVSRLGLRLVATGGMALSA 336
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 346 VCFYWRAYTfepgmDFGASAWPQF----IQGFAVACFFMPLTTITLSGLPPERMAAASSLSNFTRTLAGSIGTSITTTLW 421
Cdd:PRK14995 337 LSFYGLAMT-----DFSTQQWQAWglmaLLGFSAASALLASTSAIMAAAPPEKAAAAGAIETMAYELGAGLGIAIFGLLL 411
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 422 TNRESlhhaqlTESVNPFNPNAQQMYSELQSMGMTEQQAS---GWIAQQITN---QGLIISANEIFWISAGIFILLLGLI 495
Cdd:PRK14995 412 SRSYS------ASIRLPAGLPAQLIEKASSSIGEAVQLANslpPTLGQALLDaakQAFIWSHSVVLSSAGSMLLLLAVGV 485
|
....*
gi 1296617283 496 WFAKP 500
Cdd:PRK14995 486 WFSLA 490
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
17-413 |
7.26e-33 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 128.84 E-value: 7.26e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 17 IALSLATFMQVLDSTIANVAIPTIAGNLGSSLSQGTWVITSFGVANAISIPITGWLAKRVGEVRLFLWSTVLFVIASWAC 96
Cdd:cd17474 2 YAVFFATLLAVLGVSIVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLC 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 97 GMSNSLTMLIFFRVIQGIVAGPLIPLSQSLLLNNYPPAKRSIALALWSMTVIVAPICGPILGGYISDnYHWGWIFF---I 173
Cdd:cd17474 82 GLSDSFALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAA-ISWRYPFFllaA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 174 NVPIGALVVLMTLqslrgRETKTEQRRIDGVGLallvlgigslqimldrgkeLDWFASQEIIVLTVVAVVAISFLIvwel 253
Cdd:cd17474 161 LIPVAFLAILFLL-----PEPKEKAKSSSATKL-------------------RDLKKALRGRGLLTFLVSAFLYFF---- 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 254 tddnpivdlslfksrnftigclcislaymLYFGAIVLLPQLLQEVYGYTATWAGLASAPVGLIPVLLSPIIGRF-AHKLD 332
Cdd:cd17474 213 -----------------------------LYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVLLALGSLFVGRLlKKRFG 263
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 333 MRRLVTFSFIMYAVCFYWRAYTFEPGMDFGASawpqFIQGFAVACFFMPLTTITLSGLPPERMAAASSLSNFTRTLAGSI 412
Cdd:cd17474 264 ARRILVIGLLLYALSLLLLGFVPSLALLLIAI----VLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAV 339
|
.
gi 1296617283 413 G 413
Cdd:cd17474 340 G 340
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
17-424 |
1.29e-32 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 130.44 E-value: 1.29e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 17 IALSLATFMQVLDSTIANVAIPTIAGNLGSSlSQGTWVITSFGVANAISIPITGWLAKRVGEVRLFLWSTVLFVIASWAC 96
Cdd:cd06179 1 AALCLAYFAQLFGVTLPAAVLPFIVADLGPS-SNSTWISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIVA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 97 GMSNSLTMLIFFRVIQGIVAGpLIPLSQSLLLNNYPPAKRSIALALWSMTVIVAPICGPILGGYISDNYH--WGWIFFIN 174
Cdd:cd06179 80 GTAKSVNMLIGGQALIGIGAG-TQGLGAAVASELVPNKYRGLVQGVVNLVASPGSALGPLIAGALVEANAagWRWIFYIN 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 175 VPIGALVVLMTL--------QSLRGRETKTEQRRIDGVGLALLVLGIGSLQIMLDRGKELDWFASQEIIVLTVVAVVAIS 246
Cdd:cd06179 159 AIFNALALILLFffyhppprPQLHGSSTRQKLKRLDWVGLFLLIAGLVLFLLGLSWGGNPYPWSSAHVIAPLVIGGVLLI 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 247 FLIVWEL--TDDNPIVDLSLFKSRNFTIGCLCISLAYMLYFGAIVLLPQLLQEVYGYTATWAGLASAPVGLIPVLLSPII 324
Cdd:cd06179 239 AFGLYEWkgTKDGLLPPRLLFRGRNFALILIVAFVEGMIFYSLNIFWPQQISLLFTTDPLKAGLYQLPFGLGTLFGAILA 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 325 GRFAHKL-DMRRLVTFSFIMYAVcFYWRAYTFEPGMDFGASAWpQFIQGFAVACFFMPLTTITLSGLPPERMAAASSLSN 403
Cdd:cd06179 319 GLLLTKIkHIKWQLVAGFVLFTA-FLALLALITPDNKALAIAF-SVLAGIGIGGPLVLAIVIVQLSVPPEDIGTASGLLG 396
|
410 420
....*....|....*....|.
gi 1296617283 404 FTRTLAGSIGTSITTTLWTNR 424
Cdd:cd06179 397 SARALGGAVGTAIFTSILSNR 417
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
19-414 |
8.17e-32 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 125.22 E-value: 8.17e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 19 LSLATFMQVLDSTIANVAIP-TIAGNLGSSLSQGTWVITSFGVANAISIPITGWLAKRVGEVRLFLWSTVLFVIASWACG 97
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPlLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 98 MSNSLTMLIFFRVIQGIVAGPLIPLSQSLLLNNYPPAKRSIALALWSMTVIVAPICGPILGGYISDNYHWGWIFFINVPI 177
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 178 GALVVLMTLQSLRGRETKTEQRRIDGVGLALLVLGIgslqimldrgkeldwfasqeiivltvvavvaisflivweltddn 257
Cdd:pfam07690 161 SLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKA-------------------------------------------- 196
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 258 pivdlslFKSRNFTIGCLCISLAYMLYFGAIVLLPqLLQEVYGYTATWAGLASAPVGLIPVLLSPIIGRFAHKLDMRRLV 337
Cdd:pfam07690 197 -------LLRDPVLWLLLALLLFGFAFFGLLTYLP-LYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRL 268
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1296617283 338 TFSFIMYAVCfYWRAYTFEPGMDFGASAWPQFIQGFAVACFFMPLTTITLSGLPPERMAAASSLSNFTRTLAGSIGT 414
Cdd:pfam07690 269 LLALLLLILA-ALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
31-421 |
3.57e-29 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 118.45 E-value: 3.57e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 31 TIANVAIPTIAGNLGSSLSQGTWVITSFGVANAISIPITGWLAKRVGEVRLFLWSTVLFVIASWACGMSNSLTMLIFFRV 110
Cdd:cd17320 16 DMYLPALPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARF 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 111 IQGIVAGPLIPLSQSLLLNNYPPAKRSIALALWSMTVIVAPICGPILGGYISDNYHWGWIFFINVPIGALVVLMTLqsLR 190
Cdd:cd17320 96 LQGLGAAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLALLGLLLLLLVL--LF 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 191 GRETKTEQRRIDGVGLALLVLGigslqimldrgkeldwfasqeiivltvvavvaisflivweltddnpivdlSLFKSRNF 270
Cdd:cd17320 174 LPETLPEEKRKPLLSSLLRAYK--------------------------------------------------RVLKNRRF 203
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 271 TIGCLCISLAYMLYFGAIVLLPQLLQEVYGYTATWAGLASAPVGLIPVLLSPIIGRFAHKLDMRRLVTFSFIMYAVC-FY 349
Cdd:cd17320 204 LGYALALGLSFAGLFAYLAAAPFIYIEQLGLSPAQFGLLFALNAIALILGSLLNGRLVRRFGPRRLLRLGLLLLLAAaLV 283
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1296617283 350 WRAYTFEPGMDFGASAWPQFIQGFAVACFFMPLTTITLSGLpPERMAAASSLSNFTRTLAGSIGTSITTTLW 421
Cdd:cd17320 284 LLLAALLGGLSLWPLVAPLFLIFFGFGLIFPNATSLALEPF-PHVAGTASALLGFLQFLIGALAGALVGLLP 354
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
14-417 |
1.91e-27 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 113.04 E-value: 1.91e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 14 IMTIALSLATFMQVLDSTIANVAIPTIAGNLGSSLSQGTWVITSFGVANAISIPITGWLAKRVGEVRLFLWSTVLFVIAS 93
Cdd:COG2271 10 RILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLAT 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 94 WACGMSNSLTMLIFFRVIQGIVAGPLIPLSQSLLLNNYPPAKRSIALALWSMTVIVAPICGPILGGYISDNYHWGWIFFI 173
Cdd:COG2271 90 LLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLI 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 174 NVPIGALVVlmtlqslrgretkteqrridgvglallvlgigslqimldrgkeldwfasqeiiVLTVVAVVAISFLIvwel 253
Cdd:COG2271 170 LGLPGLLLA-----------------------------------------------------LLRFWLLALAYFLV---- 192
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 254 tddnpivdlslfksrnftigclcislaYMLYFGAIVLLPQLLQEVYGYTATWAGLASAPVGLIPVLLSPIIGRFAHKLDM 333
Cdd:COG2271 193 ---------------------------YFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGR 245
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 334 RR--LVTFSFIMYAVCFYWRAYTFEPGMDFGASawpqFIQGFAVACFFMPLTTITLSGLPPERMAAASSLSNFTRTLAGS 411
Cdd:COG2271 246 RRklVLAIGLLLAALALLLLALLPSPALAIALL----FLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGA 321
|
....*.
gi 1296617283 412 IGTSIT 417
Cdd:COG2271 322 LGPLLV 327
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
19-413 |
7.92e-24 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 103.04 E-value: 7.92e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 19 LSLATFMQVLDSTIANVAIPTIAGNLGSSLSQGTWVITSFGVANAISIPITGWLAKRVGEVRLFLWSTVLFVIASWACGM 98
Cdd:cd17325 1 LSLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 99 SNSLTMLIFFRVIQGIVAGPLIPLSQSLLLNNYPPAKRSIALALWSMTVIVAPICGPILGGYISDNYHWGWIFFINVPIG 178
Cdd:cd17325 81 ATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 179 ALVVLMTLQSLRGRETKTEQRRIDGVGLALLVlgigslqimldrgkeldwfasqeiivltvvavvaisflivweltddnp 258
Cdd:cd17325 161 LLALVLALLLLPEPRPPPNKRAVSAARLRSGL------------------------------------------------ 192
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 259 ivdLSLFKSRNFTIGCLCISLAYMLYFGAIVLLPQLLQEVYGYTATWAGLASAPVGLIPVLLSPIIGRFAHKLDMRRLVT 338
Cdd:cd17325 193 ---RLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLIL 269
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1296617283 339 FSFIMYAVCFYWRAYTfepgMDFGASAWPQFIQGFAVACFFMPLTTITLSGLPPERMAAASSLSNFTRTLAGSIG 413
Cdd:cd17325 270 IGLLLSAVALLLLPLA----TSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLG 340
|
|
| MFS_Amf1_MDR_like |
cd17476 |
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ... |
17-423 |
1.10e-23 |
|
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341029 [Multi-domain] Cd Length: 362 Bit Score: 102.34 E-value: 1.10e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 17 IALSLATFMQVLDSTIANVAIPTIAGNLGSSLSQGTWVITSFGVANAISIPITGWLAKRVGEVRLFLWSTVLFVIASWAC 96
Cdd:cd17476 1 ATISGAQLLNQAGLGSVIVILPIIGDSFGTSPNQLSWLAASYSLTVGTFILIFGRLGDIYGHKKMFVIGSFWFAIWSLIA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 97 GMSNSLTMLIFFRVIQGIVAGPLIPLSQSLLLNNYPPAK-RSIALALWSMTVIVAPICGPILGGYISDNYHWGWIFFINV 175
Cdd:cd17476 81 GFSPNFIFFIICRALQGLGPAFLLPNAMALLGRTYPPGPrKNIVFSLFGATAPLGFALGGVFGGLFAQLAWWPWIFWFLA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 176 pigalvvlmtlqslrgretkteqrridgvglallvlgigslqimldrgkeldwfasqeiIVLTVVAVVAIsflivweltd 255
Cdd:cd17476 161 -----------------------------------------------------------ILAAIVAVAAI---------- 171
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 256 dnpivdlsLFKSRNFTIGCLCISLAYMlYFGAIVL-LPQLLQEVYGYTATWAGLASAPVGLIPVLLSPIIGRFAHKLDMR 334
Cdd:cd17476 172 --------FWTSPSFIAVLLAVFLGWA-SFGIWVFyATQYFQNVRGYSPLLTSARFIPMAIGGVLAAITVGFLIARLPPS 242
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 335 RLVTFSFIMYAVcfywrAYTFEPGMDFGASAWPQFIQGFAVACF-----FMPLTTITLSGLPPERMAAASSLSNFTRTLA 409
Cdd:cd17476 243 YIMAISMVAFLV-----GPILFATMPVHQTYWAQAFPAMIVAPFgmdfsFPAATIIASNAVPREYQGLAGSLVNTVVNYG 317
|
410
....*....|....
gi 1296617283 410 GSIGTSITTTLWTN 423
Cdd:cd17476 318 ISIGLGIAGTVETS 331
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
16-423 |
1.82e-19 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 89.92 E-value: 1.82e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 16 TIALSLATFMQVLDSTIANVAIPTIAGNLGSSLSQGTWVITSFGVANAISIPITGWLAKRVGEVRLFLWSTVLFVIASWA 95
Cdd:cd17324 1 LLALALAAFAIGTTEYVIQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 96 CGMSNSLTMLIFFRVIQGIVAGPLIPLSQSLLLNNYPPAKRSIALALWSMTVIVAPICGPILGGYISDNYHWGWIFFINV 175
Cdd:cd17324 81 AALAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 176 PIGALVVLMTLQSLRGRETKTEQRRIDGVGLALlvlgigslqimldrgkeldwfasqeiivltvvavvaisflivweltd 255
Cdd:cd17324 161 VLALLAALLLWRLLPSLPPKKPGSLGLLSSLLL----------------------------------------------- 193
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 256 dnpivdlsLFKSRNFTIGCLCISLAYMLYFGAIVLLPQLLQEVYGYTATWAGLASAPVGLIPVLLSPIIGRFAHKLDMRR 335
Cdd:cd17324 194 --------LLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRA 265
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 336 LVTFSFIMYAVCFywraytfepGMDFGASAWPQFIQGFAVACFFM----PLTTITLSGLPPERMAAASSLSNFTRTLAGS 411
Cdd:cd17324 266 LLIALLLLAAALL---------LLTLLGPSPLLLLVGLVLWGLGFfaahSALQTRVLRLAPEARGLASSLYLAAYNLGGA 336
|
410
....*....|..
gi 1296617283 412 IGTSITTTLWTN 423
Cdd:cd17324 337 LGAALGGLVLDH 348
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
16-423 |
2.31e-19 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 89.94 E-value: 2.31e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 16 TIALSLATFMQVLDSTIANVAIPTIAGNLGSSLSQGTWVITSFGVANAISIPITGWLAKRVGEVRLFLWSTVLFVIASWA 95
Cdd:cd17323 1 VFIISFLTFVVTFGSSIYSPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 96 CGMSNSLTMLIFFRVIQGIVAGPLIPLSQSLLLNNYPPAKRSIALALWSMTVIVAPICGPILGGYISDNYHWGWIFFINV 175
Cdd:cd17323 81 CALAPNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFWFLA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 176 PIGAlvvlmtlqslrgretkteqrridgvglallvlgigslqimldrgkeldwfasqeiivltvVAVVAISFLIvweltd 255
Cdd:cd17323 161 IISG------------------------------------------------------------FCLILIFLFL------ 174
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 256 dnPIVDLSlfksrnftigCLCISLAYMLYFGAIVLLPQLLQEVYGYTATWAGLASAPVGLIPVLLSPIIGRFaHKLDMRR 335
Cdd:cd17323 175 --PIVLLL----------GLYVGLVYAILYLFLTAFPYVFGEVYGFSPGEVGLMYLPIGIGALIGSIIGGRL-SDYYYRR 241
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 336 LVT----------------FSFIMYAVCFYWRAYTFEPGMDFGASAWPQFIQGFAVACFFMPLTTItLSGLPPERMAAAS 399
Cdd:cd17323 242 LKKknggkpepearlppafIGAFLFPIGLFIFGWTIYPHIHWIVPIIGSAFFGFGLMLIFQSSLTY-LVDSYPKYAASAL 320
|
410 420
....*....|....*....|....
gi 1296617283 400 SLSNFTRTLAGSIGTSITTTLWTN 423
Cdd:cd17323 321 AANTLVRSIFAAIFPLFAQPMFNN 344
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
19-430 |
5.13e-18 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 85.94 E-value: 5.13e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 19 LSLATFMQVLDSTIANVAIPTIAGNLGSSLSQGTWVITSFGVANAISIPITGWLAKRVGEVRLFLWSTVLFVIASWACGM 98
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 99 SNSLTMLIFFRVIQGIVAGPLIPLSQSLLLNNYPPAKRSIALALWSMTVIVAPICGPILGGYISDNYHWGWIFFINVpIG 178
Cdd:cd06174 81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWRAVFLI-AA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 179 ALVVLMTLQSLRGRETKTEQRRIDGVGLALLVLGIGSlqimldrgkeldwfasqeiivltvvavvaisflivweltddnp 258
Cdd:cd06174 160 ALALLAAILLLLVVPDPPESARAKNEEASSKSVLKLL------------------------------------------- 196
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 259 ivdLSLFKSRNFTIGCLCISLAYMLYFGAIVLLPQLLQEVYGYTATWAGLASAPVGLIPVLLSPIIGRFAHK-LDMRRLV 337
Cdd:cd06174 197 ---KRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRlIGRKPLL 273
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 338 TFSFIMYAVCFYWRAYtfepGMDFGASAWPQFIQGFAVACFFMPLTTITLSGLPPERMAAASSLSNFTRTLAGSIGTSIT 417
Cdd:cd06174 274 LIGLLLMALGLALLLL----APSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLA 349
|
410
....*....|...
gi 1296617283 418 TTLWTNRESLHHA 430
Cdd:cd06174 350 GFLLAATFGLTGA 362
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
52-186 |
7.33e-17 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 77.30 E-value: 7.33e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 52 TWVITSFGVANAISIPITGWLAKRVGEVRLFLWSTVLFVIASWACGMSNSLTMLIFFRVIQGIVAGPLIPLSQSLLLNNY 131
Cdd:TIGR00880 1 GLLLAGYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIY 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 1296617283 132 PPAKRSIALALWSMTVIVAPICGPILGGYISDNYHWGWIFFINVPIGALVVLMTL 186
Cdd:TIGR00880 81 PPEERGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFILLA 135
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
11-380 |
1.16e-16 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 81.85 E-value: 1.16e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 11 QLVIMTIALSLATFMQVLDSTIAnvaiPTIAGNLGSSLSQGTWVITSFGVANAISIPITGWLAKRVGEVRLFLWSTVLFV 90
Cdd:COG2223 6 VLLLATLAFFLAFGVWYLWSVLA----PPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 91 IASWACGMSNSLTMLIFFRVIQGIVAGPLIPLSQSLLLNNYPPAKRSIALALWSMTVIVAPICGPILGGYISDNYHWGWI 170
Cdd:COG2223 82 IGLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNA 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 171 FFInvpigalvvlmtlqslrgretkteqrridgVGLALLVLGIGSLQIMLDRGKELDWFASQEIIVLtvvavvaisfliv 250
Cdd:COG2223 162 FLI------------------------------LGILLLVVAVLAWLFLRDPPAGAAAAAKASLRDQ------------- 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 251 weltddnpivdLSLFKSRNFTIGCLCISLAYMLYFGAIVLLPQLLQEVYGYTATWAGLASAPVGLIPVLLSPIIGRFAHK 330
Cdd:COG2223 199 -----------LEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDR 267
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 1296617283 331 LDMRRLVTFSFIMYAVCFYWRAYTFEPgmdfgasaWPQFIQGFAVACFFM 380
Cdd:COG2223 268 IGGRRVLLIVFALMALGLLLLALALGS--------LWLFLVLFLLLGLAL 309
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
17-401 |
7.00e-16 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 79.15 E-value: 7.00e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 17 IALSLATFMQVLDSTIANVAIPTIAG-NLGSSLSQGTWVITSFGVANAISIPITGWLAKRVGEVRLFLWSTVLFVIASWA 95
Cdd:cd17473 2 ITLLLASTLTVMAGAAIAPALPAIAQhFVPNSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 96 CGMSNSLTMLIFFRVIQGIVAGPLIPLSQSLLLNNYPPAKRSIALALWSMTVIVAPICGPILGGYISDnYHWGWIFFI-- 173
Cdd:cd17473 82 GLFLDSLYALLASRALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALAE-IGWRAPFLVyl 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 174 -NVPIGALVVLMTlqslrgRETKTEQRRIDGVGLAllvlgigslqimldrgkeldwfASQEIIVLTVVAVVAISFlivwe 252
Cdd:cd17473 161 lALPVLILVLLFL------PEPARKSKSAASPGAA----------------------TAAALPWKRVLPIYFLAF----- 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 253 ltddnpivdlslfksrnftigclcisLAYMLYFGAIVLLPQLLQEVYGYTATWAGLASAPVGLIPVLLSPIIGRFAHKLD 332
Cdd:cd17473 208 --------------------------LAMLLFYVIPIQLPFLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLG 261
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1296617283 333 MRRLVTFSFIMYAVCFYWRAYTFEPGMDFGASawpqFIQGFAVACFFMPLTTITLSGLPPERMAAASSL 401
Cdd:cd17473 262 KRRLLAIGFALMALGFLLLALASGLWVVLLGA----ILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGI 326
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
14-186 |
4.34e-15 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 76.46 E-value: 4.34e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 14 IMTIALSLATFMQVLDSTIANVAIPTIAGNLGSSLSQGTWVITSFGVANAISIPITGWLAKRVGEVRLFLWSTVLFVIAS 93
Cdd:cd17319 3 RIIPLLFLAYVINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFT 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 94 WACGMSNSLTMLIFFRVIQGIVAGPLIPLSQSLLLNNYPPAKRSIALALWSMTVIVAPICGPILGGYISDNYHWGWIFFI 173
Cdd:cd17319 83 ALTGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFII 162
|
170
....*....|...
gi 1296617283 174 nvpIGALVVLMTL 186
Cdd:cd17319 163 ---EGLLGLLLAV 172
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
16-420 |
1.38e-14 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 74.95 E-value: 1.38e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 16 TIALSLATFMQVLDSTIANVAIPTIA--GNLGSSLSQGTWVITSFGVANAISIPITGWLAKRVGEVRLFLWSTVLFVIAS 93
Cdd:cd17316 1 LLLAGLGWFFDAYDFFLIGFVAPVLAaeFSLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLAT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 94 WACGMSNSLTMLIFFRVIQGIVAGPLIPLSQSLLLNNYPPAKRSIALALWSMTVIVAPICGPILGGYI----SDNYHWGW 169
Cdd:cd17316 81 LLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLipllSGDWGWRI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 170 IFFINVPIGALVVLMtlqslrgretkteqrridgvglallvlgigslqimldrgkeldwfasqeiivltvvavvaisfli 249
Cdd:cd17316 161 LFLIGALPALLALLL----------------------------------------------------------------- 175
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 250 vweltddnpivdlslfksRNFTIGCLCISLA-YMLYFGAIVLLPQLLQEVYGYTATWAGLASAPVGLIPVLLSPIIGRFA 328
Cdd:cd17316 176 ------------------RRRTLLLILLWFFiSFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLS 237
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 329 HKLDMRRLVTFSFIMYAVCFYwrAYTFEPGMDFGASAWPQFIQGFAVACFFMPLTTITLSGLPPERMAAASSLSNFTRTL 408
Cdd:cd17316 238 DRIGRKKTLVIGLILSGILAL--PLFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRL 315
|
410
....*....|..
gi 1296617283 409 AGSIGTSITTTL 420
Cdd:cd17316 316 GGGGAPPLIALL 327
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
19-184 |
2.35e-13 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 71.47 E-value: 2.35e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 19 LSLATFMQVLDSTIANVAIPTIAGNLGSSLSQGTWVITSFGVANAISIPITGWLAKRVGEVRLFLWSTVLFVIASWACGM 98
Cdd:cd17489 1 ILLANFFFFLSFYLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 99 SNSLTMLIFFRVIQGIVAGPLIPLSQSLLLNNYPPAKRSIALALWSMTVIVAPICGPILGGYISDNYHWGWIFFINVPIG 178
Cdd:cd17489 81 ATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLA 160
|
....*.
gi 1296617283 179 ALVVLM 184
Cdd:cd17489 161 LLALLL 166
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
12-186 |
9.52e-13 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 69.53 E-value: 9.52e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 12 LVIMTIALSLATFMQVLDSTIANVAiptiAGNLGSSLSQGTWVITSFGVANAISIPITGWLAKRVGEVRLFLWSTVLFVI 91
Cdd:cd17325 202 LALFLAIFVLAFAFGALEPFLPLYA----AELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAV 277
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 92 ASWACGMSNSLTMLIFFRVIQGIVAGPLIPLSQSLLLNNYPPAKRSIALALWSMTVIVAPICGPILGGYISDNYHWGWIF 171
Cdd:cd17325 278 ALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPF 357
|
170
....*....|....*
gi 1296617283 172 FINVPIGALVVLMTL 186
Cdd:cd17325 358 LAAAALLLLAAVLFL 372
|
|
| TRI12 |
pfam06609 |
Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific ... |
36-424 |
2.20e-12 |
|
Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific trichothecene efflux pump proteins. Many of the genes involved in trichothecene toxin biosynthesis in Fusarium sporotrichioides are present within a gene cluster.It has been suggested that TRI12 may play a role in F. sporotrichioides self-protection against trichothecenes.
Pssm-ID: 115279 [Multi-domain] Cd Length: 598 Bit Score: 69.31 E-value: 2.20e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 36 AIPTIAGNLGSSLSQGTWViTSFGVANAISIPITGWLAKRVGEVRLFLWSTVLFVIASWACGMSNSLTMLIFFRVIQGIV 115
Cdd:pfam06609 66 ALPNILQDIGQSENQGLFS-TLWTMGQAVSILMMGRLTDRFGRRPFVIATHIIGLVGAIVGCTANKFNTLLAAMTLLGVA 144
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 116 AGPL--IPLSQSLLLNNyppAKRSIALALWSMTVIVAPICGPILGGYISDNYHWGWIFFINVPIGALVVLM--------T 185
Cdd:pfam06609 145 AGPAgaSPLFIGELMSN---KTKFLGLLIVSAPTIAMNGAGPYFGQRLAIQGNWRWIFYIYIIMSAIAVLLiiiwyhppS 221
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 186 LQSLRGRET--KTEQRRIDGVGLALLVLGIGSLQIMLD-RGKELDWFASQEIIVLTVVAVVAISFLIVWEL--TDDNPIV 260
Cdd:pfam06609 222 FAQLHGKKArkRDELAKLDWIGIFLVIAGTSLFLLGVSwGGKPNNPWNSAKIIGLISSGAGSLVIFALYEVfgKPEQPII 301
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 261 DLSLFK-SRNFTIGCLCISLAYMLYFGAIVLLPQLLQEVYGYT----------------ATWAGLAsapvglipvllspI 323
Cdd:pfam06609 302 PPALFKdTRGFVCILIISSIMGAMHLCLTIIYPQQVINIFGSSlknweetawmsatasfGTGAGVM-------------I 368
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 324 IGRFAHKLDMRRLVTFSFIMYAVCFYWRAYTFEPGMDFGASAWpQFIQGFAVAcFFMPLTTITLSGLPP-ERMAAASSLS 402
Cdd:pfam06609 369 LGNLFHLIRHIRWQILVGALWLTAFLGAMSSINRDNKNAAIAL-SFFSGFVVA-WAQDITMLLVQFITTdEDLGVAFAVV 446
|
410 420
....*....|....*....|..
gi 1296617283 403 NFTRTLAGSIGTSITTTLWTNR 424
Cdd:pfam06609 447 AAARPFAGSIFTAAFISLYSNQ 468
|
|
| efflux_Bcr_CflA |
TIGR00710 |
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ... |
36-416 |
2.30e-12 |
|
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.
Pssm-ID: 273229 [Multi-domain] Cd Length: 385 Bit Score: 68.56 E-value: 2.30e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 36 AIPTIAGNLGSSLSQGTWVITSFGVANAISIPITGWLAKRVGEVRLFLWSTVLFVIASWACGMSNSLTMLIFFRVIQGIV 115
Cdd:TIGR00710 27 AFPEIAADLSTPASIVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALSSLGLALSNNIETLLVLRFVQAFG 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 116 AGPLIPLSQSLLLNNYPPAKRSIALALWSMTVIVAPICGPILGGYISDNYHWGWIFFINVPIGALVVLMTLQSLrgRETK 195
Cdd:TIGR00710 107 ASAGSVISQALVRDIYPGEELSRIYSILMPVLALAPAVAPLLGGYILVWLSWHAIFAFLSLAGILLSALIFFIL--PETL 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 196 TEQRRIDgvglallvlgigslqimldrgkeldwfASQEIIVLtvvavvaisflivweltddnpivdLSLFKSRNFTIGCL 275
Cdd:TIGR00710 185 PYEARIQ---------------------------ISTYFETF------------------------LLLLKSKMFWGYAL 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 276 CISLAYMLYFGAIVLLPQLLQEVYGYTATWAGLASAPVGLIPVLLSPIIGRFAHKLDMRRLVTFSFIMYAVCFYWRAYTf 355
Cdd:TIGR00710 214 IYGASFGGFFAFFSGAPFVYIDIMGVSPSVFGLLFALNIIAMIFGGFLNGRFIKKWGAKSLLRMGLILFAVSAVLLEIT- 292
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1296617283 356 epgMDFGASAWPQFIqgfAVACFFMPLTTITLSGLP-------PERMAAASSLSNFTRTLAGSIGTSI 416
Cdd:TIGR00710 293 ---AILGLGSWAMII---GPMMFVGIGNSMISSIAMayaledfPHVAGTASALFGTLRLVLGAIVGYL 354
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
12-186 |
5.37e-12 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 67.20 E-value: 5.37e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 12 LVIMTIALSLATFMQVLDSTIANVAIPTIAGN-LGSSLSQGTWVITSFGVANAISIPITGWLAKRVGEVR--LFLWSTVL 88
Cdd:COG2271 178 ALLRFWLLALAYFLVYFALYGFLTWLPTYLVEvRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRklVLAIGLLL 257
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 89 FVIASWACGMSNSLTMLIFFRVIQGIVAGPLIPLSQSLLLNNYPPAKRSIALALWSMTVIVAPICGPILGGYISDNYHWG 168
Cdd:COG2271 258 AALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQ 337
|
170
....*....|....*...
gi 1296617283 169 WIFFINVPIGALVVLMTL 186
Cdd:COG2271 338 AAFLLLAALALLAALLAL 355
|
|
| PRK11102 |
PRK11102 |
Bcr/CflA family multidrug efflux MFS transporter; |
36-201 |
8.07e-12 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182964 [Multi-domain] Cd Length: 377 Bit Score: 66.86 E-value: 8.07e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 36 AIPTIAGNLGSSLSQGTWVITSFGVANAISIPITGWLAKRVGEVRLFLWSTVLFVIASWACGMSNSLTMLIFFRVIQGIV 115
Cdd:PRK11102 13 ALPVIAADFGVSAGSVQMTLSAYILGFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTIDQLIYMRFLHGLA 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 116 AGPLIPLSQSLLLNNYPPAKRSIALALWSMTVIVAPICGPILGGYISDNYHWGWIFFINVPIGALVVLMTLqsLRGRETK 195
Cdd:PRK11102 93 AAAASVVINALMRDMFPKEEFSRMMSFVTLVMTIAPLLAPIIGGWLLVWFSWHAIFWVLALAAILAAALVF--FFIPETL 170
|
....*.
gi 1296617283 196 TEQRRI 201
Cdd:PRK11102 171 PKERRQ 176
|
|
| PRK10473 |
PRK10473 |
MdtL family multidrug efflux MFS transporter; |
35-195 |
1.45e-11 |
|
MdtL family multidrug efflux MFS transporter;
Pssm-ID: 182486 [Multi-domain] Cd Length: 392 Bit Score: 66.20 E-value: 1.45e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 35 VAIPTIAGNLGSSLSQGTWVITSFGVANAISIPITGWLAKRVGEVRLFLWSTVLFVIASWACGMSNSLTMLIFFRVIQGI 114
Cdd:PRK10473 24 VGLPRIAADLNASEAQLHIAFSVYLAGMAAAMLFAGKIADRSGRKPVAIPGAALFIIASLLCSLAETSSLFLAGRFLQGI 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 115 VAGPLIPLSQSLLLNNYPPAKRSIALALWSMTVIVAPICGPILGGYISDNYHWGWIFFINVPIGALVVLMTLQSLrgRET 194
Cdd:PRK10473 104 GAGCCYVVAFAILRDTLDDRRRAKVLSLLNGITCIIPVLAPVLGHLIMLKFPWQSLFYTMAAMGILVLLLSLFIL--KET 181
|
.
gi 1296617283 195 K 195
Cdd:PRK10473 182 R 182
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
39-186 |
7.37e-11 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 63.79 E-value: 7.37e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 39 TIAGNL-------GSSLSQGTWVITSFGVANAISIPITGWLAKRVGEVRLFLWSTVLFVIASWACGMSNSLTMLIFFRVI 111
Cdd:cd17328 17 TIAGVLpdiqsdfLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQLLLFRAL 96
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1296617283 112 QGIVAGPLIPLSQSLLLNNYPPAKRSIALALWSMTVIVAPICGPILGGYISD-NYHWGWIFFINVPIGALVVLMTL 186
Cdd:cd17328 97 VGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQaTGGWRWAFRVTGVLGVLLAILLL 172
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
1-189 |
2.44e-10 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 62.37 E-value: 2.44e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 1 MQQQKPLEGAQLVIMTIALS-LATFMQVLDSTIANVAIPTIAGNLGSSLSQGTWVITSFGVANAISIPITGWLAKRVGEV 79
Cdd:TIGR00895 3 QNNIRKQPLSRYQWRAIILSfLIMLMDGYDLAAMGFAAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRR 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 80 RLFLWSTVLFVIASWACGMSNSLTMLIFFRVIQGIVAGPLIPLSQSLLLNNYPPAKRSIALALWSMTVIVAPICGPILGG 159
Cdd:TIGR00895 83 RVLLWSILLFSVFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAG 162
|
170 180 190
....*....|....*....|....*....|
gi 1296617283 160 YISDNYHWGWIFFINVPIGALVVLMTLQSL 189
Cdd:TIGR00895 163 WLIPVFGWRSLFYVGGIAPLLLLLLLMRFL 192
|
|
| MFS_ARN_like |
cd17322 |
Yeast ARN family of Siderophore iron transporters and similar proteins of the Major ... |
12-424 |
3.43e-10 |
|
Yeast ARN family of Siderophore iron transporters and similar proteins of the Major Facilitator Superfamily; The ARN family of siderophore iron transporters includes ARN1 (or ferrichrome permease), ARN2 (or triacetylfusarinine C transporter 1 or TAF1), ARN3 (or siderophore iron transporter 1 or SIT1 or ferrioxamine B permease) and ARN4 (or Enterobactin permease or ENB1). They specifically recognize siderophore-iron chelates are expressed under conditions of iron deprivation. They facilitate the uptake of both hydroxamate- and catecholate-type siderophores. This group also includes glutathione exchanger 1 (Gex1p) and Gex2p, which are proton/glutathione antiporters that import glutathione from the vacuole and exports it through the plasma membrane. The ARN family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340880 [Multi-domain] Cd Length: 514 Bit Score: 62.33 E-value: 3.43e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 12 LVIMTIALSLATFMQVLDSTIANVaIPTIAGNLGSSLSQGTWVITSFGVANAISIPITGWLAKRVGEVRLFLWSTVLFVI 91
Cdd:cd17322 1 LIILFFSLFLCGFAIGLDGQIRYS-YQAYATSSFSKHSLLSTINVVNNIVSAVSQPPYAKLSDVFGRLELFLVSLLLYVV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 92 ASWACGMSNSLTMLIFFRVIQGIVAGPLIPLSQSLLLNNYPPAKRSIALALWSMTVIVAPICGPILGGYISDNYHWGW-- 169
Cdd:cd17322 80 GTIIMAASTNVQTYAAGSVFYNAGYTGLNLLLTLILADFSSLKNRGFASAIPSLPYIITTWIGGNIAQAALPNSNWRWgy 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 170 -IFFINVPIGALVVLMTLQSLRGRETKTEQRR------------------------IDGVGLALLVLGIGS--LQIMLDR 222
Cdd:cd17322 160 gMWAIILPLSSLPLVLCLLYMQRKARKDGEIKelknqeteeqtgglsqnlvklfwkLDIFGVILLTAGLGLilVPLTLAG 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 223 GKELDWFASQeIIVLTVVAVVAISFLIVWELT-DDNPIVDLSLFKSRNFTIGCLCISLAYMLYFGAIVLLPQLLQEVYGY 301
Cdd:cd17322 240 GAKSKWKNSS-IIAMIVLGGVLLVAFLLWEAKfAKYPFLPFRLLKDRTILAACLIDFFYFFSYYIFSDYLYTVLQVAVGE 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 302 TATWAGLASAPVGLIPVLLSPIIG---RFAHKLDMrrLVTFSFIMYAVCFYWRAYTFEPGMDFGASAWPQFIQGFAVACF 378
Cdd:cd17322 319 SITSATRITNLYSFVSTVAGIFVGfliRKTRRYKV--LVIIGVPLYIVGMGLLIRYRGGSGSHGGIIGALILIGIGGGLF 396
|
410 420 430 440
....*....|....*....|....*....|....*....|....*.
gi 1296617283 379 FMPLTTITLSGLPPERMAAASSLSNFTRTLAGSIGTSITTTLWTNR 424
Cdd:cd17322 397 TYPVQVSVQASVSHQEMAVVTALLLTVYSIGGAVGAAISGAIWTQT 442
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
18-420 |
6.98e-10 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 60.71 E-value: 6.98e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 18 ALSLATFMQVLDSTIANVAIPTIAGNLGSSLSQGTWVITSFGVANAISIPITGWLAKRVGEVRLFLWSTVL-----FVIA 92
Cdd:cd06173 3 LLWLAQLLSALGDWIFTVALPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLrallaAVLA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 93 SWACGMSNSLTMLIFFRVIQGIVAGPLIPLSQSLLLNNYPPAKRSIALALWSMTVIVAPICGPILGGYISDNYHWGWIFF 172
Cdd:cd06173 83 LLALLGSLSLWLLLVLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFA 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 173 INVpIGALVVLMTLQSLRGRETKTEQRRIDGVGLALLvlgigslqimldrgKELDWFASQEIIVLTVVAVVAISFLIvwe 252
Cdd:cd06173 163 INA-LSFLLSALLLLFIRRPPPAAPGESSSLLLRDLR--------------EGLRYLRRSPLLRLLLLALALFALLG--- 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 253 ltddnpivdlslfksrnftigclcislaymlyFGAIVLLPQLLQEVYGYTATWAGLASAPVGLIPVLLSPIIGRFAHKLD 332
Cdd:cd06173 225 --------------------------------GALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRR 272
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 333 MRRLVTFSFIMYAVCFYWRAYTFEPGMDFGASawpqFIQGFAVACFFMPLTTITLSGLPPERMAAASSLSNFTRTLAGSI 412
Cdd:cd06173 273 RGRLLLIGALLLGLALLVLGLSPSLWLLLAAL----FLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPL 348
|
....*...
gi 1296617283 413 GTSITTTL 420
Cdd:cd06173 349 GALLAGLL 356
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
34-228 |
1.65e-09 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 59.59 E-value: 1.65e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 34 NVAIPTIAGNLGSSLSQGTWVITSFGVANAISIPITGWLAKRVGEVRLFLWSTVLFVIASWACGMSNSLTMLIFFRVIQG 113
Cdd:cd17312 23 SVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANIFMGFSTSLWFFAVLWGLNG 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 114 IVAGPLIPLSQSLLLNNYPPAKRSIALALWSMTVIVAPICGPILGGYISDNYHWGWIFFINVPIGALVVLMTLQSLRGRE 193
Cdd:cd17312 103 LFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRAAFLVPGIVGLVVAIILFFFLRDSP 182
|
170 180 190
....*....|....*....|....*....|....*
gi 1296617283 194 TkteqrridgvglALLVLGIGSLQIMLDRGKELDW 228
Cdd:cd17312 183 P------------YVWVLSLAYAFVYIVRYACLDW 205
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
41-190 |
2.94e-09 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 58.74 E-value: 2.94e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 41 AGNLGSSLSQGTWVITSFGVANAISIPITGWLAKRVGEVRLFLWSTVLFVIASWACGMSNSLTMLIFFRVIQGIVAGpLI 120
Cdd:cd17330 26 FNKLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNLWLLFLARFLDGLTGG-NV 104
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 121 PLSQSLLLNNYPPAKRSIALALWSMTVIVAPICGPILGGYISDNYHWGWIFFINVPIGALVVLMTLQSLR 190
Cdd:cd17330 105 SVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAAALALLNLVLVLFFLP 174
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
13-186 |
3.21e-09 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 58.76 E-value: 3.21e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 13 VIMTIALSLAtFMQVLDSTIANVaIPTIAGNLGssLSQGTWVITSFGVANAISIPITGWLAKRVGEVRLFLWSTVLFVIA 92
Cdd:cd17489 195 KVLPPALILF-LASIAYGAISTF-LPLYAAERG--ISNAGLFFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALG 270
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 93 SWACGMSNSLTMLIFFRVIQGIVAGPLIPLSQSLLLNNYPPAKRSIALALWSMTVIVAPICGPILGGYISDNYHWGWIFF 172
Cdd:cd17489 271 LLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFL 350
|
170
....*....|....
gi 1296617283 173 INVPIGALVVLMTL 186
Cdd:cd17489 351 LAAVVVLLALVLYI 364
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
40-348 |
1.05e-08 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 57.24 E-value: 1.05e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 40 IAGNLGSSLSQGTWVITSFGVANAISIPITGWLAKRVGEVRLFLWSTVLFVIASWACGMSNSLTMLIFFRVIQGIVAGPL 119
Cdd:cd17329 26 LHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGLF 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 120 IPLSQSLLLNNYPPAKRSIALALWSMTVIVAPICGPILGGYISDnYHWGWIFFINVPIGALVVLMTLQSLRGRETKTEQR 199
Cdd:cd17329 106 EPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLL-YSFRLLFLAAAVLFLLAALVLLFLLPETRPKRRAA 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 200 RIDGVGLALLVlgigslqimldrgkeldwfasqeiivltvvavvaisflivweltddnpivdlsLFKSRNFTIGCLCISL 279
Cdd:cd17329 185 EKTEILRGYKI-----------------------------------------------------VLRDRAFLLFLLASFL 211
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1296617283 280 AYMLYFGAIVLLPQLLQEVYGYTATWAGLASAPVGLIPVLLSPIIGRFAHKLDMRRLVTFSFIMYAVCF 348
Cdd:cd17329 212 ISLIYFQLESTLPVYVVEILGLGESLLGLLLALNALLIVLLQFPVARLVERFRLRKILMIGILLFAIGF 280
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
16-173 |
1.40e-08 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 56.79 E-value: 1.40e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 16 TIALSLATFMQVLDSTIANVAIPTIAGNLGSSLSQGTWVITSFGVANAISIPITGWLAKRVGEVRLFLWS-------TVL 88
Cdd:cd17380 1 VILLFLATCICYADRVNMPIAIVPMAKEFGWSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAvalwslaTLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 89 FVIASWAcgmsnSLTMLIFFRVIQGIVAGPLIPLSQSLLLNNYPPAKRSIALA-LWSMTVIVAPICGpILGGYISDNYHW 167
Cdd:cd17380 81 TPLLAYS-----SLPLLILSRILLGLGEGVHFPSMTSLFSRWVPVSERSRAVSiVTAGSYLGTLLGG-LIGPLLLEYYGW 154
|
....*.
gi 1296617283 168 GWIFFI 173
Cdd:cd17380 155 PSVFYF 160
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
53-183 |
1.59e-08 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 56.42 E-value: 1.59e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 53 WVITSFGVANAISIPITG-WLAKRVGEVRLFLWSTVLFVIASWACGMSNSLTMLIFFRVIQGIVAGPLIPLSQSLLLNNY 131
Cdd:cd17474 238 LLFAGWSVLLALGSLFVGrLLKKRFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELA 317
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 1296617283 132 PPAKRSIALALWSMTVIVAPICGPILGGYISDNYHWGWIFFinvpIGALVVL 183
Cdd:cd17474 318 PEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFL----VGAAIAL 365
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
34-190 |
1.78e-08 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 56.47 E-value: 1.78e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 34 NVAIPTIA-GNLGSSLSQGTWVITSFGVANAISIPITGWLAKRVGEVRLFLWSTVLFVIASWACGMSNSLTMLIFFRVIQ 112
Cdd:cd06173 228 TVLLPLLAkEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLL 307
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1296617283 113 GIVAGPLIPLSQSLLLNNYPPAKRSIALALWSMTVIVAPICGPILGGYISDNYHWGWIFFInvpIGALVVLMTLQSLR 190
Cdd:cd06173 308 GLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLL---AGALLLLAALLLLL 382
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
14-402 |
3.56e-08 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 55.63 E-value: 3.56e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 14 IMTIALSLATFMQVLDSTIANVAIPTIAGNLGSSLSQGTWVITSFGVANAISIPITGWLAKRVGEVRLFLWSTVLFVIAS 93
Cdd:COG0738 8 RALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 94 WACGMSNSLTMLIFFRVIQGIVAGPLIPLSQSLLLNNYPPAKRSI---ALALWSmtviVAPICGPILGGYisdnyhwgwi 170
Cdd:COG0738 88 LLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGPETAASRlnlLHAFFS----LGALLGPLLGGL---------- 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 171 fFINVPIGALVVLMTLqslrgretkteqrridGVGLALLVLGIGSLQIMLDRGKELDwfasqeiivltvvavvaisfliv 250
Cdd:COG0738 154 -LILLGLSLSWHLPYL----------------ILAVLLLLLALLFLRSKLPEIEEEE----------------------- 193
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 251 wELTDDNPIVDLSLFKSRNFTIGCLCISLAYMLYFGAIVLLPQLLQEVYGYTATWAGLA-SAPVGLIpvllspIIGRFA- 328
Cdd:COG0738 194 -EEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGlSLFWGGM------TIGRFLg 266
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1296617283 329 ----HKLDMRRLVTFSFIMYAVCFYWRAYTfePGMDFGASAWpqFIQGFAVACFFMPLTTITLSGLPPERMAAASSLS 402
Cdd:COG0738 267 gfllKRFGPVRLLRLSALLAAVGLLLALLA--PGPWLALIGL--ALVGLGLSLMFPTIFSLALDGLGKRTAAAVSAVL 340
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
34-202 |
5.35e-08 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 55.07 E-value: 5.35e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 34 NVAIPTIAGNLGSSLSQGTWVITSFGVANAISIPITGWLAKRVGEVRLFLWSTVLFVIASWACGMSNSLTMLIFFRVIQG 113
Cdd:TIGR00881 15 ALAMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLWVMAALWALNG 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 114 IVAGPLIPLSQSLLLNNYPPAKRSIALALWSMTVIVAPICGP-ILGGYISDNYHWGWIFFINVPIGALVVLMTLQSLRGR 192
Cdd:TIGR00881 95 IFQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPpLVLFGIAELYSWHWVFIVPGIIAIIVSLICFLLLRDS 174
|
170
....*....|
gi 1296617283 193 ETKTEQRRID 202
Cdd:TIGR00881 175 PQSCGLPPAE 184
|
|
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
29-117 |
6.31e-08 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 54.88 E-value: 6.31e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 29 DSTIANVAIPTIAGNLGSSLSQGTWVITSFGVANAISIPITGWLAKRVGEVRLFLWSTVLFVIASWACGMSNSLTMLIFF 108
Cdd:cd17359 16 DTGVINGALPFLQTDFNLTPFLEGLVVSSALLGAAIGALFAGRLADRFGRRKTLLISAVLFFISALGSAFSPNFTIFIIA 95
|
....*....
gi 1296617283 109 RVIQGIVAG 117
Cdd:cd17359 96 RIIGGLAVG 104
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
19-185 |
2.47e-07 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 52.56 E-value: 2.47e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 19 LSLATFMQVLDSTIANVAIPTIAGNLGSSLSQGTWVITSFGVANAISIPITGWLAKRVGEVRLFLWSTVLFVIASWACGM 98
Cdd:cd17477 1 LLLSVALLGLGSGLLLPLLSLRLEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 99 SNSLTMLIFFRVIQGIVAGPLIPLSQSLLLNNYPPAKRSIALALWSMTVIVAPICGPILGGYIS-DNYHWGWIFFINVPI 177
Cdd:cd17477 81 TDSPWVWFLLRFVMGIGLAGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFALGPLLLALVGtAGALPFLIAAVLLLL 160
|
....*...
gi 1296617283 178 GALVVLMT 185
Cdd:cd17477 161 ALVPLLLT 168
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
12-348 |
3.12e-07 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 52.57 E-value: 3.12e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 12 LVIMTIALSLATFMqvldsTIANVAIPTIAGNLGSSLSQGTWVITSFGVANAISIPITGWLAKRVGEVRLFLWSTVLFVI 91
Cdd:COG2807 21 LAIVLVALNLRPAI-----TSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAA 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 92 ASWACGMSNSLTMLIFFRVIQGI---VAGPLIPlsqsLLLNNYPPAKRSIALALWSMTVIVAPICGPILGGYISDNYHW- 167
Cdd:COG2807 96 GLLLRSLAPSVALLLAGTALIGAgiaVGNVLLP----GLIKRWFPDRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWr 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 168 GWIFFINVPIGALVVLMTLQSLRGRETKTEQRRIDGVGlallvlgigslqimldrgkeldwfasqeiivltvvavvaisf 247
Cdd:COG2807 172 GALAVWALLALLALLLWLPLLRRRPAAAAAAPAAASLR------------------------------------------ 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 248 livweltddnpivdlSLFKSRNFTIGCLCISLAYMLYFGAIVLLPQLLQEvYGYTATWAGLASAPVGLIPVLLSPIIGRF 327
Cdd:COG2807 210 ---------------SLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILRD-AGLSAATAGLLLSLFQLAGIPGSLLVPLL 273
|
330 340
....*....|....*....|..
gi 1296617283 328 AHKLDMRR-LVTFSFIMYAVCF 348
Cdd:COG2807 274 ADRLGDRRpLLLLLGLLGLAGL 295
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
25-184 |
3.16e-07 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 52.69 E-value: 3.16e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 25 MQVLDSTIANVAIPTIAGNLGSSLSQGTWVITSFGVANAISIPITGWLAKRVGEVRLFLWSTVLFVIASWACGMSNSLTM 104
Cdd:cd17371 10 LDGFDLLLLGLVLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQ 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 105 LIFFRVIQGIVAGPLIPLSQSLLLNNYPPAKRSIALAL----WSMTVIVAPICGPILGGYISDNYHWGWIFFINVpIGAL 180
Cdd:cd17371 90 LLILRALAGLGFGGEWAAGAALMAEYVPARHRGKALGYvqsgWAVGWLLATLLAALLFPLLPPEIAWRVLFLLGA-LPAL 168
|
....
gi 1296617283 181 VVLM 184
Cdd:cd17371 169 LVLF 172
|
|
| MFS_GLUT_like |
cd17315 |
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ... |
20-186 |
4.15e-07 |
|
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 52.19 E-value: 4.15e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 20 SLATFMQVLDSTIANVAIPTIAGNLGSSLS--QGTWVITSFGVANAISIPITGWLAKRVGEVRLFLWSTVLFVIASWACG 97
Cdd:cd17315 3 ALGGLLFGYDLGVINGALLYIAKDLGFGLStsLQGLVVSSLLLGAAIGSLFGGPLADRFGRRKSLLIAAVLYVIGALLSA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 98 MSNSLTMLIFFRVIQGIVAGpLIPLSQSLLLNNYPPAKRSIAL-ALWSMTVIVAPICGPILGGYISDNYHWGWIFFINV- 175
Cdd:cd17315 83 LAPNVWVLIVGRFLLGLGVG-LASVLVPLYISEIAPAKIRGALgTLNQLMITFGILLAYLLGLALSLSPPGWWRLMFALa 161
|
170
....*....|...
gi 1296617283 176 --PIGALVVLMTL 186
Cdd:cd17315 162 avPALLQLLLMFF 174
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
21-186 |
5.89e-07 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 51.45 E-value: 5.89e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 21 LATFMQVLDSTIANVAIPTIAGNLGSSLSQGTWVITSFGVANAISIPITGWLA-KRVGEVRLFLWSTVLFVIASWACGMS 99
Cdd:cd17490 202 LAILQQMITFSTTFGFTPLIAKQLGASSFQLGLLSIIYLLPNALASLLSGTLFyKKLGERNTIIIGFLLLGAYCFLIPFA 281
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 100 NSLTMLIFFRVIQGIVAGPLIPLSQSLLLNNYPPAKRSIALALWSMTVIVAPICGPILGGYISDNYHWGWIFFINVPIGA 179
Cdd:cd17490 282 PNLTLLYLLQALNGFGTGILFPLLMSLSIEGVPAEQRSTAMGFFQAIYALGMFLGPVLVGIISEAFGLQTGFFVIGVIAL 361
|
....*..
gi 1296617283 180 LVVLMTL 186
Cdd:cd17490 362 LAAILSL 368
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
21-184 |
7.31e-07 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 51.05 E-value: 7.31e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 21 LATFMQVLDSTIANVAIPTIAGNLGSSLSQGTWVITSFGVANAISIPITGWLAKRVGEVRLFLWSTVLFVIASWACGMSN 100
Cdd:cd17365 6 LIIVLDGFDLAVMGFVAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQ 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 101 SLTMLIFFRVIQGIVAGPLIPLSQSLLLNNYPPAKRSIALALWSMTVIVAPICGPILGGYISDNYHWGWIFFIN-VPIGA 179
Cdd:cd17365 86 SVLQLALLRFLTGLGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLLGgVPPLI 165
|
....*
gi 1296617283 180 LVVLM 184
Cdd:cd17365 166 LLPLL 170
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
12-182 |
1.56e-06 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 50.26 E-value: 1.56e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 12 LVIMTIALSLATFMQVldstianVAIPTIAGNLGSSLSQGT-WVITSFGVANAISIPITGWLAKRVGEVRLFLWSTVLFV 90
Cdd:cd17473 202 IYFLAFLAMLLFYVIP-------IQLPFLLQERGGGSAALIgLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMA 274
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 91 IASWACGMSNSLTMLIFFRVIQGIVAGPLIPLSQSLLLNNYPPAKRSIALALWSMTVIVAPICGPILGGYISDNYHWGWI 170
Cdd:cd17473 275 LGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLVLGPLVNLTGGLSG 354
|
170
....*....|..
gi 1296617283 171 FFINVPIGALVV 182
Cdd:cd17473 355 AFLILGVLALVL 366
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
11-161 |
1.60e-06 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 50.29 E-value: 1.60e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 11 QLVIMTIALSLATFMqvldstIANVAIPTIAGNLGSSLSQGTWVITSFGVANAISIPITGWLAKRVGEVRLFLWSTVLFV 90
Cdd:COG2211 232 LLLLAYLLFFLALAL------VAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAA 305
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 91 IASWACGMS--NSLTMLIFFRVIQGIVAGPLIPLSQSLLLNNYPPAK-------RSIALALWSMTVIVAPICGPILGGYI 161
Cdd:COG2211 306 LGLLLLFFLgpGNLWLLLVLAALAGIGLGAILVLPWAMLADVVDYDEwktgrrrEGLYFGIFTFAIKLGQALAGALAGLL 385
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
31-186 |
2.92e-06 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 49.49 E-value: 2.92e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 31 TIANVAIPTIAGNLGSSLSQGTWVITSFGVANAISIPITGWLAKRVGEVRLFLWSTVLFVIASWACGM-SNSLTMLIFFR 109
Cdd:COG2223 223 GFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALaLGSLWLFLVLF 302
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 110 VIQGIVAGPLIPLSQSLLLNNYPPAKRSIALALWSMTVIVAPICGPILGGYISD---NYHWGWIFFINVPIGALVVLMTL 186
Cdd:COG2223 303 LLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDatgSYTAAFLVFAVLALVALVLTLLL 382
|
|
| PRK09874 |
PRK09874 |
multidrug efflux MFS transporter MdtG; |
62-190 |
4.02e-06 |
|
multidrug efflux MFS transporter MdtG;
Pssm-ID: 182127 [Multi-domain] Cd Length: 408 Bit Score: 49.15 E-value: 4.02e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 62 NAISIPITGWLAKRVGEVRLFLWSTVLFVIASWACGMSNSLTMLIFFRVIQGIVAGpLIPLSQSLLLNNYPPAKRSIALA 141
Cdd:PRK09874 67 SAIASPFWGGLADRKGRKIMLLRSALGMGIVMVLMGLAQNIWQFLILRALLGLLGG-FVPNANALIATQVPRNKSGWALG 145
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 1296617283 142 LWSMTVIVAPICGPILGGYISDNYHWGWIFFINVPIGALVVLMTLQSLR 190
Cdd:PRK09874 146 TLSTGGVSGALLGPLAGGLLADSYGLRPVFFITASVLFLCFLVTLFCIR 194
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
11-186 |
8.38e-06 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 48.03 E-value: 8.38e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 11 QLVIMTIALSLATFMQVLDSTIANVAipTIAGnlgsslsqgtWVITSFGVANAISIPITGWLAKRVGEVRLFLWSTVLFV 90
Cdd:cd17391 214 QLANQSIEPILTLYIRQLMGDASNLA--FISG----------LVFSATGVSSLLSAPRLGKLGDRIGHHRILLGALLASA 281
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 91 IASWACGMSNSLTMLIFFRVIQGIVAGPLIPLSQSLLLNNYPPAKRSIALALWSMTVIVAPICGPILGGYISDNYHWGWI 170
Cdd:cd17391 282 LLYIPQAFVQTPWQLGILRFLLGLATGGLLPAINSLLAKITPKEVAGRIFGYNQSFQYLGNVAGPLLGSAIAAHFGYRAV 361
|
170
....*....|....*....
gi 1296617283 171 FFIN---VPIGALVVLMTL 186
Cdd:cd17391 362 FVVTallVLLNAIWSFIFL 380
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
18-186 |
9.59e-06 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 47.95 E-value: 9.59e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 18 ALSLATFMQVLDSTIANVAIPTIAGNLGSSLSQGTWVITSFGVANAISIPITGWLAKRVGEVRLFLWSTVLFVIASWACG 97
Cdd:COG2807 219 LLTLFFGLQSLLYYAVVAWLPPILRDAGLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDRRPLLLLLGLLGLAGLLGL 298
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 98 MSNSLTMLIFFRVIQGIVAGPLIPLSQSLLLNNYPPAKRSIALALWSMTV--IVApICGPILGGYISD---NYHWGWIFF 172
Cdd:COG2807 299 LLAPGSLPWLWAVLLGLGQGGLFPLALTLIGLRARTPAEAAALSGMAQSVgyLLA-ALGPLLVGALHDatgSWTAALLLL 377
|
170
....*....|....
gi 1296617283 173 INVPIGALVVLMTL 186
Cdd:COG2807 378 AALAVLMLVAGLLA 391
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
11-195 |
9.81e-06 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 47.93 E-value: 9.81e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 11 QLVIMTIALSLATFMQVldstIANVAIPTIAGN-LGSSLSQGTWVITSFGVANAISIPITGWLAKRVGEVRLFLWSTVLF 89
Cdd:COG0738 211 RLLLGGLAIFLYVGAEG----AIGDWLPLYLKDvLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLA 286
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 90 VIASWACGMSNSLTMLIFFRVIQGIVAGPLIPLSQSLLLNNyPPAKRSIALALWSMTVIVAPICGPILGGYISDNYHWGW 169
Cdd:COG0738 287 AVGLLLALLAPGPWLALIGLALVGLGLSLMFPTIFSLALDG-LGKRTAAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRA 365
|
170 180
....*....|....*....|....*.
gi 1296617283 170 IFFINVPIGALVVLMTLQSLRGRETK 195
Cdd:COG0738 366 AFLVPLVCYLLILLLALALKRKRRKK 391
|
|
| emrD |
PRK11652 |
multidrug transporter EmrD; |
4-200 |
1.26e-05 |
|
multidrug transporter EmrD;
Pssm-ID: 183259 [Multi-domain] Cd Length: 394 Bit Score: 47.59 E-value: 1.26e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 4 QKPLEGAQLVIMTIALSLATFMQvldSTIANVAIPTIAGNLGSSLSQGTWVITSFGVANAISIPITGWLAKRVGEVRLFL 83
Cdd:PRK11652 1 MKRQRNVNLLFMLVLLVAVGQMA---QTIYVPAIADMARDLNVREGAVQAVMAAYLLTYGLSQLFYGPLSDRVGRRPVIL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 84 WSTVLFVIASWACGMSNSLTMLIFFRVIQGIVAGPLIPLSQSLLLNNYPPAKRSIALALWSMTVIVAPICGPILGGYISD 163
Cdd:PRK11652 78 VGMSIFILGTLVALFAHSLTVLIAASAIQGLGTGVGGVMARTLPRDLYEGTQLRHANSLLNMGILVSPLLAPLIGGLLTT 157
|
170 180 190
....*....|....*....|....*....|....*..
gi 1296617283 164 NYHWGWIFFINVPIGALVVLMTLQSLrgRETKTEQRR 200
Cdd:PRK11652 158 LFGWRACYLFLLLLGAGVTFSMARWM--PETRPADAR 192
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
12-186 |
1.50e-05 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 47.21 E-value: 1.50e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 12 LVIMTIALSLATFMQVLDSTIANVAIPTI-AGNLGSSLSQGTWVITSFGVANAISIPITGWLAKRVGEVRLFLWSTVLFV 90
Cdd:cd17316 175 LRRRTLLLILLWFFISFGYYGLTTFLPTYlQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSG 254
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 91 IASWACGM--SNSLTMLIFFRVIQGIVAGPLIPLSQSLLLNNYPPAKRSIALAL-WSMTVIVAPICGPILGGYISDNYHW 167
Cdd:cd17316 255 ILALPLFYllSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLsYNLGRLGGGGAPPLIALLLASTGGT 334
|
170
....*....|....*....
gi 1296617283 168 GwIFFINVPIGALVVLMTL 186
Cdd:cd17316 335 G-VPALILALLAIVALIVA 352
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
70-183 |
1.51e-05 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 47.23 E-value: 1.51e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 70 GWLAKRVGEVRLFLWST----VLFVIASWACGMSnsLTMLIFFRVIQGIVAGPLIPLSQSLLLNNYPPAKRSIALALWSM 145
Cdd:cd17318 77 GYLAEKYGAKRVLGYSIlitaLLTLLTPLAARGG--YGALIVLRILQGLAQGVTFPAMHALWAKWAPPLERSRLTSIAYS 154
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 1296617283 146 -----TVIVAPICgpilgGYISDNYHWGWIFFInvpIGALVVL 183
Cdd:cd17318 155 gsqfgTVIAMPLS-----GFLCESLGWPSIFYI---FGGLGLL 189
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
6-192 |
2.12e-05 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 46.81 E-value: 2.12e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 6 PLEGAQLVIMTIALSLATFMQVLDSTIANVAIPTIAGNLGSSLSQGTWVITSFGVANAISIPITGWLAKRVGEVRLFLWS 85
Cdd:cd17365 163 PLILLPLLRGTLLLWVTFFMGLLLVYLLNSWLPKLMVEAGYSLSQALTITLLLNIGGVIGSLLLGWLADRFGPKRVLALF 242
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 86 TVLFVIASWACGMSNSLTMLIFfrvIQGIVAGPLIPLSQSLLL----NNYPPAKRSIALAlWSMTV-IVAPICGPILGGY 160
Cdd:cd17365 243 FALGAVSLALLGVSPASLVLLY---VLVFLAGACVNGAQVGLYalaaRFYPTEVRATGVG-WALGVgRLGAILGPLLGGL 318
|
170 180 190
....*....|....*....|....*....|...
gi 1296617283 161 -ISDNYHWGWIFFINVPIGALVVLMTLQSLRGR 192
Cdd:cd17365 319 lLAAGLGPESVFLALAIPAALGALAVLLLRLRR 351
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
172-422 |
2.34e-05 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 46.82 E-value: 2.34e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 172 FINVPIGALVVLMTlQSLRGRETKTEQRRI-DGVGLALLVLGIGSLQIMLDRGKELDWFASQEIIVLTVVAVVAISFLIV 250
Cdd:COG2211 126 LVNIPYSALGAELT-PDYEERTRLSSWRFAfAGLGGLLASVLPPPLVAAFGGDAALGYRLTALIFAVLGLLAFLLTFFGT 204
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 251 WEL-TDDNPIVDL-----SLFKSRNFTIGCLCISLAYMLYFGAIVLLPQLLQEVYGYTATWAGLASAPVGLIPVLLSPII 324
Cdd:COG2211 205 KERpVPEEEKVSLkeslkALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLW 284
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 325 GRFAHKLDMRRLVTFSFIMYAVCFYWrAYTFEPGmDFGASAWPQFIQGFAVAcFFMPLTTITLSGLPPE--------RMA 396
Cdd:COG2211 285 PRLAKRFGKKKAFIIGLLLAALGLLL-LFFLGPG-NLWLLLVLAALAGIGLG-AILVLPWAMLADVVDYdewktgrrREG 361
|
250 260
....*....|....*....|....*.
gi 1296617283 397 AASSLSNFTRTLAGSIGTSITTTLWT 422
Cdd:COG2211 362 LYFGIFTFAIKLGQALAGALAGLLLA 387
|
|
| MFS_MFSD9 |
cd17390 |
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ... |
36-162 |
2.66e-05 |
|
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340948 [Multi-domain] Cd Length: 350 Bit Score: 46.45 E-value: 2.66e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 36 AIPTIAGNLGSSlsqgtwvitsFGVANAISIPITGWLAKRVGEVRLFLWSTVLFVIASWACGMSNSLTMLIFFRVIQGIV 115
Cdd:cd17390 28 ASPTVIGLIGSV----------YGALQLFSSPLVGSWSDVVGRRPVLLICLLLTALGYVLLGFSTSLALLFLSRIPLGIF 97
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 1296617283 116 AGPLiPLSQSLLLNNYPPAKRSIALALWSMTVIVAPICGPILGGYIS 162
Cdd:cd17390 98 KHTQ-SLCKAYLSDLVSEQERSRVLGRFNAASSLGFILGPVVGGHLA 143
|
|
| MFS_SLCO_OATP |
cd17336 |
Solute carrier organic anion transporters of the Major Facilitator Superfamily of transporters; ... |
14-348 |
4.43e-05 |
|
Solute carrier organic anion transporters of the Major Facilitator Superfamily of transporters; Solute carrier organic anion transporters (SLCOs) are also called organic anion transporting polypeptides (OATPs) or SLC21 (Solute carrier family 21) proteins. They are sodium-independent transporters that mediate the transport of a broad range of endo- as well as xenobiotics. Their substrates are mainly amphipathic organic anions with a molecular weight of more than 300Da, although there are a few known neutral or positively charged substrates. These include drugs including statins, angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, antibiotics, antihistaminics, antihypertensives, and anticancer drugs. SLCOs/OATPs can be classified into 6 families (SLCO1-6 or OATP1-6) and each family may have subfamilies (e.g. OATP1A, OATP1B, OATP1C). Within the subfamilies, individual members are numbered according to the chronology of their identification and if there is already an ortholog known, they are given the same number. For example, the first SLCO identified, is rat OATP1A1 (encoded by the Slco1a1 gene). The second SLCO identified is the first human SLCO from the same subfamily and is called OATP1A2 (encoded by the SLCO1A2 gene). There are 11 human SLCOs/OATPs. SLCOs belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340894 [Multi-domain] Cd Length: 411 Bit Score: 45.69 E-value: 4.43e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 14 IMTIALSLATFMQVLDSTIANVAIPTIAGNLGSSLSQGTWVITSFGVANAISIPITGWLAKRVGEVRLFLWSTVLFVIAs 93
Cdd:cd17336 3 VFVVLLCLLGLLQGAVVSYFVSTITTIEKRFGLSSSQSGLILSANDIGQLLAVLLVSYFGGRGHRPRWIGIGSILMGLG- 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 94 waCGMSNSLTMLIFFRVIQGIVAGPLIPLSQSLLLNNYPPAKRSIALALWSMTVIVAPICGPILGGyisdnyhwgwiFFI 173
Cdd:cd17336 82 --CFLLALPHFLFVGQFLLGIGSSPLYTLGITYIDDNVSKKNSPLYIGILYAMRVLGPALGFLLGS-----------FLL 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 174 NVPIGALVVLMTLqslrgreTKTEQRRIDGVGLALLVLGIgslqimldrgkeldwfasqeiivLTVVAVVAISFLivwel 253
Cdd:cd17336 149 RIYVDFSRVPLGI-------TPDDPRWIGAWWLGFLILGI-----------------------LLLIVSIPLFFF----- 193
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 254 tddnPIVdlslfksrnFTIGCLCISLAYMLYFGAIVLLPQLLQEVYGYTATWAGLASAPVGLIPVLLSPIIG-----RFa 328
Cdd:cd17336 194 ----PPI---------FILLLLAIVFESFAISGFSTFLPKYLETQFRLSASLASLLTGLILVPGAALGILLGgliikKF- 259
|
330 340
....*....|....*....|
gi 1296617283 329 hKLDMRRLVTFSFIMYAVCF 348
Cdd:cd17336 260 -KLTARGLAKFVLILSLLSV 278
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
274-420 |
6.67e-05 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 45.10 E-value: 6.67e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 274 CLCISLAYMLYFGAIVLLPQLLQEVYGYTATWAGLASAPVGLIPVLLSPIIGRFAHKLDMRRLVTFSFIMYAVCFYWRAY 353
Cdd:pfam07690 2 FLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLF 81
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1296617283 354 TFepgmDFGASAWPQFIQGFAVACFFMPLTTITLSGLPPERMAAASSLSNFTRTLAGSIGTSITTTL 420
Cdd:pfam07690 82 AS----SLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLL 144
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
38-186 |
7.05e-05 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 45.23 E-value: 7.05e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 38 PTIAGNLGSSLSQGTWVITSFGVANAISIPITGWLAKRVGEVRLFLWSTVLFVIASWACGMSNSLTMLIFFRVIQGIVAG 117
Cdd:cd17324 223 PFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFF 302
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1296617283 118 PLIPLSQSLLLNNYPPAkRSIALALWSMTVIVAPICGPILGGYISDNYHWGWIFFInvpIGALVVLMTL 186
Cdd:cd17324 303 AAHSALQTRVLRLAPEA-RGLASSLYLAAYNLGGALGAALGGLVLDHGGWAGVGWV---GAALLLLALL 367
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
4-161 |
1.12e-04 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 44.65 E-value: 1.12e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 4 QKPLEGAQLVIMTIALSLATFMQVLDSTIANVAIPTIAGNLGSSLSQGTWVITSFGVANAISIPITGWLAKRVGEVRLFL 83
Cdd:TIGR00895 240 FKALFQGKTARITVLLWLLYFMLLVGVYFLTNWLPKLMVELGFSLSLAATGGALFNFGGVIGSIIFGWLADRLGPRVTAL 319
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1296617283 84 WSTVLFVIASWACGMSNSLTMLIFFRVIQGIVAGPLIPLSQSLLLNNYPPAKRSIALALWSMTVIVAPICGPILGGYI 161
Cdd:TIGR00895 320 LLLLGAVFAVLVGSTLFSPTLLLLLGAIAGFFVNGGQSGLYALMALFYPTAIRATGVGWAIGIGRLGAIIGPILAGYL 397
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
42-183 |
1.51e-04 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 44.19 E-value: 1.51e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 42 GNLGSSLSQGTWVITSFGVANAISIPITGWLAKRVGEVRLFLWSTVLFVIASWACGMS---NSLTMLIFFRVIQGIVAGP 118
Cdd:pfam00083 39 SSLAALSVLSGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIGAVLQGAAkgkWSVYQLIVGRVLVGIGVGG 118
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1296617283 119 LIPLSQSLLLNNYPPAKRSIALALWSMTVIVAPICGPILG---GYISDNYHWGWIFFINVPIGALVVL 183
Cdd:pfam00083 119 ASVLAPMYISEIAPKKLRGALGSLYQLAITFGILLAYIFGlglNKTSNSDGWRIPLGLQLVPALLLII 186
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
1-186 |
1.63e-04 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 44.18 E-value: 1.63e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 1 MQQQKPLEGAQLVIMTIALSLA-TFMQVLDSTIANVAIPTIAGNLGSSLSQGTWVitsFGVANAISIP---ITGWLAKRV 76
Cdd:PRK11551 1 MSTRTSSASSSRLALTIGLCFLvALLEGLDLQSAGVAAPRMAQEFGLDVAQMGWA---FSAGILGLLPgalLGGRLADRI 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 77 GEVRLFLWSTVLFVIASWACGMSNSLTMLIFFRVIQGIVAGPLIPLSQSLLLNNYPPAKRSIALALWsmtvivapICGPI 156
Cdd:PRK11551 78 GRKRILIVSVALFGLFSLATAQAWDFPSLLVARLLTGVGLGGALPNLIALTSEAVGPRLRGTAVSLM--------YCGVP 149
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 1296617283 157 LGGYI--------SDNYHWGWIFFIN--VPIGALVVLMTL 186
Cdd:PRK11551 150 FGGALasvigvlaAGDAAWRHIFYVGgvGPLLLVPLLMRW 189
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
5-190 |
2.08e-04 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 43.34 E-value: 2.08e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 5 KPLEGAQLVIMTIALSLATFMQVLdstianvaIPTIAGNLGSSLSQGTWVITSFGVANAIS-IPITGWLAKRVGEVRLFL 83
Cdd:cd17330 174 PPLRRLLLVYFLIALAFAGLESVF--------SLFLKDRFGFSPSQIGLLLALVGIAGILAqLLLIPRLAKRLGERKLLR 245
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 84 WSTVLFVIASWACGMSNSLTMLIFFRVIQGIVAGPLIPLSQSLLLNNYPPAKRSIALALWSMTVIVAPICGPILGGYISD 163
Cdd:cd17330 246 LGLLLAIIGLLLLPFASSVPLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYS 325
|
170 180
....*....|....*....|....*..
gi 1296617283 164 NYHWGWIFFINvpiGALVVLMTLQSLR 190
Cdd:cd17330 326 FLGPGVPFLLA---AGLLLIALFLLSL 349
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
50-139 |
2.41e-04 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 43.34 E-value: 2.41e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 50 QGTWVITSFGVANAISIPITGWLAKRVGEVRLFLWSTVLFVIASWACGMSNSLTMLIFFRVIQGIVAGPLIPLSQSLLLN 129
Cdd:cd17317 26 LVALVQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGIFTVGFVLGME 105
|
90
....*....|
gi 1296617283 130 NYPPAKRSIA 139
Cdd:cd17317 106 IVGPKYRSFV 115
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
270-420 |
3.06e-04 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 42.93 E-value: 3.06e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 270 FTIGCLCISLAYMLYFGAIVLLPQLLQEvYGYTATWAGLASAPVGLIPVLLSPIIGRFAHKLDMRRLVTFSFIMYAVCFY 349
Cdd:COG2271 12 LALLFLAYFLNYLDRSNLSVAAPPLQAD-LGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATL 90
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1296617283 350 WRAYTFEPGMDFGAsawpQFIQGFAVACFFMPLTTITLSGLPPERMAAASSLSNFTRTLAGSIGTSITTTL 420
Cdd:COG2271 91 LFGFATSFWQLLLL----RFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWL 157
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
272-420 |
3.37e-04 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 43.04 E-value: 3.37e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 272 IGCLCISLAYMLYFGAIVLLPQLLQEVYGYTATWAGLASAPVGLIPVLLSPIIGRFAHKLDMRRLVTFSFIMYAVCFYWR 351
Cdd:COG2814 13 LALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLC 92
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1296617283 352 AYTFEPGMDFGASawpqFIQGFAVACFFMPLTTITLSGLPPERMAAASSLSNFTRTLAGSIGTSITTTL 420
Cdd:COG2814 93 ALAPSLWLLLAAR----FLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLL 157
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
21-186 |
3.45e-04 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 42.80 E-value: 3.45e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 21 LATFMQVLDSTIANVAIPTIAGNLGSSLSQGTWVITSFGVANAISIPITGWLAKRVGEVRLFLWSTVLFVIASWAC-GMS 99
Cdd:cd06174 211 AIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALlLLA 290
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 100 NSLTMLIFFRVIQGIVAGPLIPLSQSLLLNNYPPAKRSIALALWSMTVIVAPICGPILGGYISDNYH-WGWIFFINVPIG 178
Cdd:cd06174 291 PSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFgLTGAFLVLAVLL 370
|
....*...
gi 1296617283 179 ALVVLMTL 186
Cdd:cd06174 371 LLAAILLL 378
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
17-155 |
3.72e-04 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 42.79 E-value: 3.72e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 17 IALSLATFMQVLDSTIANVAIPTIAGNLGSSLSQGTWVITSFGVANAISIPITGWLAKRVGEVRLFLWSTVLFVIASWAC 96
Cdd:pfam07690 203 LWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGL 282
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1296617283 97 ---GMSNSLTMLIFFRVIQGIVAGPLIPLSQSLLLNNYPPAKRSIALALWSMTVIVAPICGP 155
Cdd:pfam07690 283 lllSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
54-186 |
4.16e-04 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 42.64 E-value: 4.16e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 54 VITSFGVANAISIPITGWLAKRVGEVRLFLWSTVLFVIASWACGMSNSLTMLIFFRVIQGIVAGpLIPLSQSLLLNNYPP 133
Cdd:cd17391 41 AFSSTFLVSAIFSPIWGRLADRYGRKPMLLRASLGMAIVIGLMAFVTNVWQLLILRLLQGVFSG-YVPNATALIASQTPK 119
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 1296617283 134 AKRSIALALWSMTVIVAPICGPILGGYISDNYHWGWIFFINVPIGALVVLMTL 186
Cdd:cd17391 120 EKSGWALGTLSTGVVAGTLIGPLLGGFLADLFGIRNVFFITGGLLFLAFLLTL 172
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
43-184 |
4.49e-04 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 42.55 E-value: 4.49e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 43 NLGSSLSQGTWVITSFGVANAISIPITGWLAKRVGEVRLFLWSTVLFVIAS--WACGMSNSLTMLIFFRVIqGIVAGPLI 120
Cdd:cd17477 217 RLGLSVAQAALLLAAFVLGGLLLQWPLGWLADRFDRRRVLLGCALLGALAAllLPLVPGLPLALLVLLFLW-GGAAGPLY 295
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1296617283 121 PLSQSLLLNNYPPAKRSIALALWSMTVIVAPICGPILGGYISDNY-HWGWIFFINVPIGALVVLM 184
Cdd:cd17477 296 TLALALAGDRLPGDELVAANAALLLLYGLGSVIGPLLAGALMDAFgPHGLFLFLAAVALLFLLFL 360
|
|
| BtlA |
COG2270 |
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ... |
31-194 |
5.59e-04 |
|
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];
Pssm-ID: 441871 [Multi-domain] Cd Length: 424 Bit Score: 42.45 E-value: 5.59e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 31 TIANVAIPTIAGNLGSSLSQgtwVITSFGVANAISIP---ITGWLAKRVGEVRLFLWS-TVLFVIASWACGMSNSLTMLI 106
Cdd:COG2270 256 TVIAFAGIYAAGVLGFSTTE---LIVFGLLVQIVAALgalLFGRLDDRIGPKRVILVSlVIWIVVCLAAYFLTTALAFWI 332
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 107 FFRVIqGIVAGPLIPLSQSLLLNNYPPAKRSIALALWSMTVIVAPICGPILGG---YISDNYHWGWIFFINVPIGALVVL 183
Cdd:COG2270 333 LGLLI-GLVMGGIQALSRSLLARLIPPGREAEFFGLYALSGKAASFLGPLLFGlvtQLTGSQRLGILSLIVFFVIGLVLL 411
|
170
....*....|.
gi 1296617283 184 MTLQSLRGRET 194
Cdd:COG2270 412 LRVKVPRGRAA 422
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
268-420 |
6.40e-04 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 42.18 E-value: 6.40e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 268 RNFTIGCLCISLAYMLYFGAIVLLPQLlQEVYGYTATWAGLASAPVGLIPVLLSPIIGRFAHKLDMRRLVTFSFIMYAVC 347
Cdd:COG2223 5 RVLLLATLAFFLAFGVWYLWSVLAPPL-AEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIG 83
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1296617283 348 FYWRAYTFEPGMDFGASawpqFIQGFAVACFFMPLTTITLSGLPPERMAAASSLSNFTRTLAGSIGTSITTTL 420
Cdd:COG2223 84 LLLLALAVSYWLLLLLG----LLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLL 152
|
|
| PRK11043 |
PRK11043 |
Bcr/CflA family multidrug efflux MFS transporter; |
36-202 |
6.91e-04 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182924 [Multi-domain] Cd Length: 401 Bit Score: 42.19 E-value: 6.91e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 36 AIPTIAGNLGSSLSQGTWVITSFGVANAISIPITGWLAKRVGEVRLFLWSTVLFVIASWACGMSNSLTMLIFFRVIQGIV 115
Cdd:PRK11043 28 AFKAIQADLQTSASAVSASLSLFLAGFALGQLLWGPLSDRYGRKPVLLAGLSLFALGSLGMLWVESAAQLLVLRFVQAVG 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 116 AGPLIPLSQSLLLNNYPPAKRSIALALWSMTVIVAPICGPILGGYISDNYHWGWIFFINVPIGALVVLMTL-QSLRGRET 194
Cdd:PRK11043 108 VCSAAVIWQALVIDRYPAQKANRVFATIMPLVALSPALAPLLGAWLLNHFGWQAIFATLFAITLLLILPTLrLKPSKKAR 187
|
....*...
gi 1296617283 195 KTEQRRID 202
Cdd:PRK11043 188 KQSQDALT 195
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
58-186 |
9.71e-04 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 41.43 E-value: 9.71e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 58 FGVANAI-SIPItGWLAKRVGEVRLFLWSTVLFVIASWACGMSNSLTMLIFFRVIQGI--VAGPLIPLSQSLLlnnyPPA 134
Cdd:cd17472 41 YGLTQAIfQIPF-GLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQGSgaISSVVMALLADLT----REE 115
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 1296617283 135 KRSIALALWSMTVIVAPICGPILGGYISDNYHWGWIFFINVPIGALVVLMTL 186
Cdd:cd17472 116 NRTKAMALIGASIGIAFAISMVLGPLLAAHLGVSGLFLITAILSLVSLLILL 167
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
9-179 |
1.03e-03 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 41.39 E-value: 1.03e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 9 GAQLVIMTIALSLATFMQVLDSTIANVaiptiagnLGSSLSQGTWVITSFGVANAISIPITGWLAKRVGEVRLFLWSTVL 88
Cdd:cd17321 172 GAVLAAFLLGAALGGLLFLLPLYLQGV--------LGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLL 243
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 89 FVIASWA---CGMSNSLTMLIFFRVIQGIVAGPLIPLSQSLLLNNYPPAKRSIALALWSMT-----VIVAPICGPILGGY 160
Cdd:cd17321 244 TAVGLLLlalLGADSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTArqlggALGVALLGALLTAG 323
|
170
....*....|....*....
gi 1296617283 161 ISDNYHWGWIFFINVPIGA 179
Cdd:cd17321 324 LSANLGDSGVAALLSAAAA 342
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
13-166 |
1.18e-03 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 41.00 E-value: 1.18e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 13 VIMTIALSLATFMQVldstIANVAIPTIAGNLGSSLSQGTWVITSFGVANAISIPITGWLA--KRVGEVRLFLWSTVLFV 90
Cdd:cd17352 186 VLLALGVSFAMLGFF----VPFVYLPSYAKSLGIDESDAAFLLSIIGISDIVGRILLGLLAdkPRIGRLYLYIFTLLILG 261
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1296617283 91 IASWACGMSNSLTMLIFFRVIQGIVAGPLIPLSQSLLLNNYPPAKRSIALALWSMTVIVAPICGPILGGYISDNYH 166
Cdd:cd17352 262 LSLLAFPLATTYVGLIVFSVLFGFCSGSYSSLTPVILADLVGLEKLSNAYGLVLLFQGLAALVGPPIAGLLRDYTG 337
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
58-186 |
1.56e-03 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 40.99 E-value: 1.56e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 58 FGVANAISIPI---TGWLAKRVGEVRLFLWSTVLFVIASWACGMSNSLTMLIFFRVIQ----GIVAGPLIPLSQSLLlnn 130
Cdd:cd17471 241 FGLAAALEIPImllAGLLAKRFGKRRLLLAGFLAGVLFYLGLALATSLWQLIALQLLNaifiGITAGLGISYFQDLM--- 317
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 1296617283 131 ypPAKRSIALALWSMTVIVAPICGPILGGYISDNYHWGWIFFINVPIGALVVLMTL 186
Cdd:cd17471 318 --PGQPGLATTLYSNASRIGSLLGGLLAGVIAQYFGYRAVFLVCAVLALLALVLLL 371
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
279-423 |
1.82e-03 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 40.66 E-value: 1.82e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 279 LAYMLYFGAIVLLPQLLQEvYGYTATWAGLASAPVGLIPVLLSPIIGRFAHKLDMRRLVTFSFIMYAVCFYWRAYTFEPG 358
Cdd:cd17489 7 FFFLSFYLLLPVLPLYAHD-LGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVA 85
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1296617283 359 MDFGASawpqFIQGFAVACFFMPLTTITLSGLPPERMAAASSLSNFTRTLAGSIGTSITTTLWTN 423
Cdd:cd17489 86 LLLVLR----LIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQH 146
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
19-186 |
1.86e-03 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 40.72 E-value: 1.86e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 19 LSLATFMQVLDSTIANVAIPTIAGNLGSSLSQGTWVITSFGVANAISIPITGWLAKRVGEVRLFLWSTVLFVIASWACGM 98
Cdd:cd17355 215 LALAFFLCGFAVVGLIVHLVPYLADRGISPAAAAVALALIGLFNIVGRLLSGWLGDRYSPRRLLAASYALRALGLALLLL 294
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 99 S-NSLTMLIFFRVIQGIVAGPLIPLSQSLLLNNYPPAKRSIALALWSMTVIVAPICGPILGGYISD---NYHWGWIFFIN 174
Cdd:cd17355 295 LpFPPLALLLFAALFGLGWGATVPLTAALAARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDrtgSYTAAWALAVA 374
|
170
....*....|..
gi 1296617283 175 VPIGALVVLMTL 186
Cdd:cd17355 375 LGLIAALLVLPI 386
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
272-417 |
2.13e-03 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 40.63 E-value: 2.13e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 272 IGCLCISLAYMLYFGAIVLLPQLLQEVYGYTATWAGLASAPVGLIPVLLSPIIGRFAHKLDMRRLVTFSFIMYAVCFYWR 351
Cdd:COG2807 21 LAIVLVALNLRPAITSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLR 100
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1296617283 352 AYTFEPGMDFGASAwpqfIQGFAVACFFMPLTTItLSGLPPERMAAASSLSNFTRTLAGSIGTSIT 417
Cdd:COG2807 101 SLAPSVALLLAGTA----LIGAGIAVGNVLLPGL-IKRWFPDRVGLMTGLYTAAMGLGAALAAGLT 161
|
|
| MFS_MFSD10 |
cd17389 |
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily ... |
64-183 |
2.59e-03 |
|
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily domain-containing protein 10 (MFSD10) is also called tetracycline transporter-like protein (TETRAN). It is expressed in various human tissues, including the kidney. In cultured cells, its overexpression facilitated the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs). MFSD10/TETRAN overexpression cause resistance to some NSAIDs, suggesting that it may be an organic anion transporter that serves as an efflux pump for some NSAIDs and various other organic anions at the final excretion step. MFSD10 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340947 [Multi-domain] Cd Length: 391 Bit Score: 40.34 E-value: 2.59e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 64 ISIPITGWLAKRVGEVRLFLWSTVLFVIAS--WACgmSNSLTMLIFFRVIQGIVAGPlIPLSQSLLLNNYPPAKRSIALA 141
Cdd:cd17389 79 LSSPITGAASDVYGRKPVLLLTMIGLAISYalWAV--SRSFTIFLLSRIVGGISKGN-VSLSTAIVADVTSPKKRSKGMA 155
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 1296617283 142 LWSMTVIVAPICGPILGGYISDNY-HWGWIFFINVPIGALVVL 183
Cdd:cd17389 156 LIGVAFSLGFIIGPMIGAYFASFTrSLGEVFFSMPALFALVLA 198
|
|
| PRK09874 |
PRK09874 |
multidrug efflux MFS transporter MdtG; |
7-192 |
3.60e-03 |
|
multidrug efflux MFS transporter MdtG;
Pssm-ID: 182127 [Multi-domain] Cd Length: 408 Bit Score: 39.90 E-value: 3.60e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 7 LEGAQLVIMTIALSLatFMQVLDSTIANVA---IPTIAGNLGSSLSQGTWVITSFGVANAISIPITGWLAKRVGEVRLFL 83
Cdd:PRK09874 215 LKNPKLVLSLFVTTL--IIQVATGSIAPILtlyVRELAGNVSNIAFISGMIASVPGVAALLSAPRLGKLGDRIGPEKILI 292
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 84 WSTVLFVIASWACGMSNSLTMLIFFRVIQGIVAGPLIPLSQSLLLNNyppAKRSIALALWSMTVI---VAPICGPILGGY 160
Cdd:PRK09874 293 TALIFSVLLLIPMSFVQTPLQLGILRFLLGAADGALLPAVQTLLVYN---SSNQIAGRIFSYNQSfrdIGNVTGPLMGAA 369
|
170 180 190
....*....|....*....|....*....|..
gi 1296617283 161 ISDNYHWGWIFFINVPIGALVVLMTLQSLRGR 192
Cdd:PRK09874 370 ISANYGFRAVFLVTAGVVLFNAVYSWNSLRRR 401
|
|
| PRK10091 |
PRK10091 |
MFS transport protein AraJ; Provisional |
17-183 |
5.14e-03 |
|
MFS transport protein AraJ; Provisional
Pssm-ID: 182234 [Multi-domain] Cd Length: 382 Bit Score: 39.31 E-value: 5.14e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 17 IALSLATFMQVLDSTIANVAIPTIAGNLGSSLSQGTWVITSFGVANAISIPITGWLAKRVGEVRLFLWSTVLFVIASWAC 96
Cdd:PRK10091 6 LSLALGTFGLGMAEFGIMGVLTELAHDVGISIPAAGHMISYYALGVVVGAPIIALFSSRYSLKHILLFLVALCVIGNAMF 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 97 GMSNSLTMLIFFRVIQGIVAGPLIPLSQSLLLNNYPPAKRSIALALWSMTVIVAPICGPILGGYISDNYHWGWIFFINVP 176
Cdd:PRK10091 86 TLSSSYLMLAIGRLVSGFPHGAFFGVGAIVLSKIIKPGKVTAAVAGMVSGMTVANLLGIPLGTYLSQEFSWRYTFLLIAV 165
|
....*..
gi 1296617283 177 IGALVVL 183
Cdd:PRK10091 166 FNIAVLA 172
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
66-187 |
5.94e-03 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 39.13 E-value: 5.94e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 66 IPITGWLaKRVGEVRLFLWSTVLFVIASWACGMSNSLTMLIFFRVIqgIVAGPLI--PLSQSLLLNNYPPAKRSIALALW 143
Cdd:cd17329 254 FPVARLV-ERFRLRKILMIGILLFAIGFAVLAFANTLAVLILAMIV--LTLGEMLvfPAVQTLVAALAPPDKRGSYMGFY 330
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 1296617283 144 SMTVIVAPICGPILGGYISD--NYHWGWIFFINVPIGALVVLMTLQ 187
Cdd:cd17329 331 ALAWGLGRAIGPLVGGLLLDllGPGLPWLILAALGLIAAALLLGLQ 376
|
|
| 2A0114euk |
TIGR00894 |
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions] |
64-184 |
7.48e-03 |
|
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
Pssm-ID: 129972 [Multi-domain] Cd Length: 465 Bit Score: 38.96 E-value: 7.48e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 64 ISIPItGWLAKRVGEVR-----LFLWSTVLFVIAsWACGMSnsLTMLIFFRVIQGIVAGPLIPLSQSLLLNNYPPAKRSI 138
Cdd:TIGR00894 92 IQIPV-GYLAGKYVFKWsigigMFLSSVISIVIP-WAAGGG--IALVVFCRVIQGLAQGSVSPATHKIIVKWAPPKERSR 167
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 1296617283 139 ALAL-WSMTVIVAPICGPILGGYISDNYHWGWIFFINVPIGALVVLM 184
Cdd:TIGR00894 168 LLGMsTSGFQLGTFIFLPISGWLCESWGGWPMIFYVFGIVGCAWSLL 214
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
43-142 |
8.41e-03 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 38.66 E-value: 8.41e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296617283 43 NLGSSLSQGTWVITSFGVANAISIPITGWLAKRVGEVRLFLWSTVLFVIAS----WACGMSNSLTMLIFFRVIQGIVAGP 118
Cdd:cd17369 258 TLGVDRSTVLLAVLIASVVAAITIPLFGWLSDRVGRRPVYLAGALLAALFAfpffWLLDTGSTWLIVLAAVVVLGVLHGM 337
|
90 100
....*....|....*....|....
gi 1296617283 119 LIPLSQSLLLNNYPPAKRSIALAL 142
Cdd:cd17369 338 MYGPQAAFLAELFPTRVRYTGASL 361
|
|
| |
