NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1311527422|ref|WP_101162755|]
View 

MULTISPECIES: glycosyltransferase family A protein [unclassified Pseudoalteromonas]

Protein Classification

glycosyltransferase family A protein( domain architecture ID 18912029)

glycosyltransferase family A protein is glycosyl transferase with a common GT-A type structural fold

CATH:  3.90.550.10
EC:  2.4.-.-
Gene Ontology:  GO:0016757|GO:0006486
PubMed:  10521532|12691742|9445404|12200473|10508766
SCOP:  3000077

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Glyco_tranf_GTA_type cd00761
Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a ...
 49-105 7.16e-06

Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Glycosyltransferases (GTs) are enzymes that synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein. Based on the stereochemistry of the donor and acceptor molecules, GTs are classified as either retaining or inverting enzymes. To date, all GT structures adopt one of two possible folds, termed GT-A fold and GT-B fold. This hierarchy includes diverse families of glycosyl transferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. The majority of the proteins in this superfamily are Glycosyltransferase family 2 (GT-2) proteins. But it also includes families GT-43, GT-6, GT-8, GT13 and GT-7; which are evolutionarily related to GT-2 and share structure similarities.


:

Pssm-ID: 132997 [Multi-domain]  Cd Length: 156  Bit Score: 44.80  E-value: 7.16e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1311527422  49 ISKKERGSSKSRNLAIENASGDICIIADDDVSYLENYESIVKDAYIKYPDADIITFQ 105
Cdd:cd00761    58 INEENQGLAAARNAGLKAARGEYILFLDADDLLLPDWLERLVAELLADPEADAVGGP 114
WcaA super family cl33890
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 51-206 4.99e-04

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


The actual alignment was detected with superfamily member COG0463:

Pssm-ID: 440231 [Multi-domain]  Cd Length: 208  Bit Score: 40.07  E-value: 4.99e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1311527422  51 KKERGSSKSRNLAIENASGDICIIADDDVSYLENY-ESIVkdAYIKYPDADIITFQIQTTEGKPFKPNYSNEEYYHTK-- 127
Cdd:COG0463    65 ERNRGKGAARNAGLAAARGDYIAFLDADDQLDPEKlEELV--AALEEGPADLVYGSRLIREGESDLRRLGSRLFNLVRll 142

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1311527422 128 MSILKCASIEITFKRESIiksglkldLEFGLGSKYRVHDEIIFlkdALDNGLKCVYIPlpiVVHPPESSGTDYNEQLLF 206
Cdd:COG0463   143 TNLPDSTSGFRLFRREVL--------EELGFDEGFLEDTELLR---ALRHGFRIAEVP---VRYRAGESKLNLRDLLRL 207
 
Name Accession Description Interval E-value
Glyco_tranf_GTA_type cd00761
Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a ...
 49-105 7.16e-06

Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Glycosyltransferases (GTs) are enzymes that synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein. Based on the stereochemistry of the donor and acceptor molecules, GTs are classified as either retaining or inverting enzymes. To date, all GT structures adopt one of two possible folds, termed GT-A fold and GT-B fold. This hierarchy includes diverse families of glycosyl transferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. The majority of the proteins in this superfamily are Glycosyltransferase family 2 (GT-2) proteins. But it also includes families GT-43, GT-6, GT-8, GT13 and GT-7; which are evolutionarily related to GT-2 and share structure similarities.


Pssm-ID: 132997 [Multi-domain]  Cd Length: 156  Bit Score: 44.80  E-value: 7.16e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1311527422  49 ISKKERGSSKSRNLAIENASGDICIIADDDVSYLENYESIVKDAYIKYPDADIITFQ 105
Cdd:cd00761    58 INEENQGLAAARNAGLKAARGEYILFLDADDLLLPDWLERLVAELLADPEADAVGGP 114
WcaA COG0463
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 51-206 4.99e-04

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440231 [Multi-domain]  Cd Length: 208  Bit Score: 40.07  E-value: 4.99e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1311527422  51 KKERGSSKSRNLAIENASGDICIIADDDVSYLENY-ESIVkdAYIKYPDADIITFQIQTTEGKPFKPNYSNEEYYHTK-- 127
Cdd:COG0463    65 ERNRGKGAARNAGLAAARGDYIAFLDADDQLDPEKlEELV--AALEEGPADLVYGSRLIREGESDLRRLGSRLFNLVRll 142

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1311527422 128 MSILKCASIEITFKRESIiksglkldLEFGLGSKYRVHDEIIFlkdALDNGLKCVYIPlpiVVHPPESSGTDYNEQLLF 206
Cdd:COG0463   143 TNLPDSTSGFRLFRREVL--------EELGFDEGFLEDTELLR---ALRHGFRIAEVP---VRYRAGESKLNLRDLLRL 207
Glycos_transf_2 pfam00535
Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, ...
 44-114 1.23e-03

Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.


Pssm-ID: 425738 [Multi-domain]  Cd Length: 166  Bit Score: 38.53  E-value: 1.23e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1311527422  44 DDITMISKKER-GSSKSRNLAIENASGDICIIADDDVSYLENY-ESIVKdaYIKYPDADIITFQIQTTEGKPF 114
Cdd:pfam00535  53 PRVRVIRLPENrGKAGARNAGLRAATGDYIAFLDADDEVPPDWlEKLVE--ALEEDGADVVVGSRYVIFGETG 123
 
Name Accession Description Interval E-value
Glyco_tranf_GTA_type cd00761
Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a ...
 49-105 7.16e-06

Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Glycosyltransferases (GTs) are enzymes that synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein. Based on the stereochemistry of the donor and acceptor molecules, GTs are classified as either retaining or inverting enzymes. To date, all GT structures adopt one of two possible folds, termed GT-A fold and GT-B fold. This hierarchy includes diverse families of glycosyl transferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. The majority of the proteins in this superfamily are Glycosyltransferase family 2 (GT-2) proteins. But it also includes families GT-43, GT-6, GT-8, GT13 and GT-7; which are evolutionarily related to GT-2 and share structure similarities.


Pssm-ID: 132997 [Multi-domain]  Cd Length: 156  Bit Score: 44.80  E-value: 7.16e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1311527422  49 ISKKERGSSKSRNLAIENASGDICIIADDDVSYLENYESIVKDAYIKYPDADIITFQ 105
Cdd:cd00761    58 INEENQGLAAARNAGLKAARGEYILFLDADDLLLPDWLERLVAELLADPEADAVGGP 114
WcaA COG0463
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 51-206 4.99e-04

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440231 [Multi-domain]  Cd Length: 208  Bit Score: 40.07  E-value: 4.99e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1311527422  51 KKERGSSKSRNLAIENASGDICIIADDDVSYLENY-ESIVkdAYIKYPDADIITFQIQTTEGKPFKPNYSNEEYYHTK-- 127
Cdd:COG0463    65 ERNRGKGAARNAGLAAARGDYIAFLDADDQLDPEKlEELV--AALEEGPADLVYGSRLIREGESDLRRLGSRLFNLVRll 142

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1311527422 128 MSILKCASIEITFKRESIiksglkldLEFGLGSKYRVHDEIIFlkdALDNGLKCVYIPlpiVVHPPESSGTDYNEQLLF 206
Cdd:COG0463   143 TNLPDSTSGFRLFRREVL--------EELGFDEGFLEDTELLR---ALRHGFRIAEVP---VRYRAGESKLNLRDLLRL 207
Succinoglycan_BP_ExoA cd02525
ExoA is involved in the biosynthesis of succinoglycan; Succinoglycan Biosynthesis Protein ExoA ...
 46-102 6.15e-04

ExoA is involved in the biosynthesis of succinoglycan; Succinoglycan Biosynthesis Protein ExoA catalyzes the formation of a beta-1,3 linkage of the second sugar (glucose) of the succinoglycan with the galactose on the lipid carrie. Succinoglycan is an acidic exopolysaccharide that is important for invasion of the nodules. Succinoglycan is a high-molecular-weight polymer composed of repeating octasaccharide units. These units are synthesized on membrane-bound isoprenoid lipid carriers, beginning with galactose followed by seven glucose molecules, and modified by the addition of acetate, succinate, and pyruvate. ExoA is a membrane protein with a transmembrance domain at c-terminus.


Pssm-ID: 133016 [Multi-domain]  Cd Length: 249  Bit Score: 40.29  E-value: 6.15e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1311527422  46 ITMISKKERGSSKSRNLAIENASGDICIIADDDVSYLENY-ESIVKDAyiKYPDADII 102
Cdd:cd02525    59 IRLIDNPKRIQSAGLNIGIRNSRGDIIIRVDAHAVYPKDYiLELVEAL--KRTGADNV 114
BcsA COG1215
Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1, ...
 41-215 8.20e-04

Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1,6-N-acetylglucosamine synthase [Cell motility];


Pssm-ID: 440828 [Multi-domain]  Cd Length: 303  Bit Score: 40.11  E-value: 8.20e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1311527422  41 ETLDDITMISKKERGS-SKSRNLAIENASGDICIIADDDVSYLENY-ESIVkdAYIKYPDADII-TFQIqttegkpfkpn 117
Cdd:COG1215    83 AEYPRVRVIERPENGGkAAALNAGLKAARGDIVVFLDADTVLDPDWlRRLV--AAFADPGVGASgANLA----------- 149

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1311527422 118 ysneeyyhtkmsilkcasieitFKRESIIKSGlkldlefGLgSKYRVHDEIIFLKDALDNGLKCVYIPLPIVVH-PPESS 196
Cdd:COG1215   150 ----------------------FRREALEEVG-------GF-DEDTLGEDLDLSLRLLRAGYRIVYVPDAVVYEeAPETL 199

                         170
                  ....*....|....*....
gi 1311527422 197 GTDYNEQLLFSKGAAFYRL 215
Cdd:COG1215   200 RALFRQRRRWARGGLQLLL 218
Glycos_transf_2 pfam00535
Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, ...
 44-114 1.23e-03

Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.


Pssm-ID: 425738 [Multi-domain]  Cd Length: 166  Bit Score: 38.53  E-value: 1.23e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1311527422  44 DDITMISKKER-GSSKSRNLAIENASGDICIIADDDVSYLENY-ESIVKdaYIKYPDADIITFQIQTTEGKPF 114
Cdd:pfam00535  53 PRVRVIRLPENrGKAGARNAGLRAATGDYIAFLDADDEVPPDWlEKLVE--ALEEDGADVVVGSRYVIFGETG 123
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH