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Conserved domains on  [gi|1328117890|ref|WP_102227321|]
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HAMP domain-containing sensor histidine kinase [Dolosicoccus paucivorans]

Protein Classification

sensor histidine kinase( domain architecture ID 11428264)

sensor histidine kinase is part of a two-component regulatory system and functions as a protein kinase that phosphorylates a target protein in response to a signal

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
KdpD COG2205
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
218-437 3.55e-28

K+-sensing histidine kinase KdpD [Signal transduction mechanisms];


:

Pssm-ID: 441807 [Multi-domain]  Cd Length: 239  Bit Score: 111.54  E-value: 3.55e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1328117890 218 IEVKNKEIIKLEQMKYDFLRGSSHELKTPLSRMKIILENMKYNIGKYK-DRDLYIDKCLDITNELTYNISQILTFSSLEY 296
Cdd:COG2205     2 LEEALEELEELERLKSEFLANVSHELRTPLTSILGAAELLLDEEDLSPeERRELLEIIRESAERLLRLIEDLLDLSRLES 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1328117890 297 --LKDDEEWVTIKSVLDAVLVKYDELAMRNHLTFNSTIQSEQLLIG--KKALNLVLSNLISNAVKYSEPNSVITIDIKND 372
Cdd:COG2205    82 gkLSLELEPVDLAELLEEAVEELRPLAEEKGIRLELDLPPELPLVYadPELLEQVLANLLDNAIKYSPPGGTITISARRE 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1328117890 373 ----WLCVTN----MthSEVNLKPLMDiKF----DLNKEGSHGLGLYIIKTLLKNYGIEYAVENTDR---TFTFKIKLNE 437
Cdd:COG2205   162 gdgvRISVSDngpgI--PEEELERIFE-RFyrgdNSRGEGGTGLGLAIVKRIVEAHGGTIWVESEPGggtTFTVTLPLAE 238
HAMP COG2770
HAMP domain [Signal transduction mechanisms];
10-356 1.78e-05

HAMP domain [Signal transduction mechanisms];


:

Pssm-ID: 442051 [Multi-domain]  Cd Length: 631  Bit Score: 47.03  E-value: 1.78e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1328117890  10 MFIQIFSVLVLFIMIIHLLVFFMFPKSYLETRKHELTVKANEIAEYLDGKDLNYITQSLEFFSSSNDIKAFIKKGVNANE 89
Cdd:COG2770    85 VALAALLLALLLLLLLALLLLLAALLLLLLLAALALLLLLLLLLAALLALLLALALLALLLGLAAARLLLAALLALAAAL 164
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1328117890  90 LAIDEGIDVNLNSNTNSLIVEDRAIHSSSGVELMINFVSTADMLKEAKSISfkflpLSVIFSIAVSIIIAFIYAKMIKHN 169
Cdd:COG2770   165 ALALGAGELLLLADLAAAIAALLAALLLLLLGGLLLVVLLEAALAALLLLL-----LLALLALLLALLLALLLARRITRP 239
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1328117890 170 IGEIKDVTDQMMQLDRQAYLKVNSADEIAELKLQINELYRSLLSSIDDIEVKNKEIIKLEQMkyDFLRGSSHELKTPLSR 249
Cdd:COG2770   240 LRRLAEAARRIAAGDLDVRIPVSRKDEIGELARAFNRMADSLRESIEEAEEEEELAEAELAR--LLEALLELLLALLLLL 317
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1328117890 250 MKIILENMKYNIGKYKDRDLYIDKCLDITNELTYNISQILTFSSLEYLKDDEEWVTIKSVLDAVLVKYDELAMRNHLTFN 329
Cdd:COG2770   318 LALLLLAAAALLLELLLLLLLALLLLLLLAADLLLALALAALLLLLALELLLEAELLVLLALEALALEAELAAVLALLAA 397
                         330       340
                  ....*....|....*....|....*..
gi 1328117890 330 STIQSEQLLIGKKALNLVLSNLISNAV 356
Cdd:COG2770   398 LAAALLLLELALEELVLALLALALLAL 424
 
Name Accession Description Interval E-value
KdpD COG2205
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
218-437 3.55e-28

K+-sensing histidine kinase KdpD [Signal transduction mechanisms];


Pssm-ID: 441807 [Multi-domain]  Cd Length: 239  Bit Score: 111.54  E-value: 3.55e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1328117890 218 IEVKNKEIIKLEQMKYDFLRGSSHELKTPLSRMKIILENMKYNIGKYK-DRDLYIDKCLDITNELTYNISQILTFSSLEY 296
Cdd:COG2205     2 LEEALEELEELERLKSEFLANVSHELRTPLTSILGAAELLLDEEDLSPeERRELLEIIRESAERLLRLIEDLLDLSRLES 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1328117890 297 --LKDDEEWVTIKSVLDAVLVKYDELAMRNHLTFNSTIQSEQLLIG--KKALNLVLSNLISNAVKYSEPNSVITIDIKND 372
Cdd:COG2205    82 gkLSLELEPVDLAELLEEAVEELRPLAEEKGIRLELDLPPELPLVYadPELLEQVLANLLDNAIKYSPPGGTITISARRE 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1328117890 373 ----WLCVTN----MthSEVNLKPLMDiKF----DLNKEGSHGLGLYIIKTLLKNYGIEYAVENTDR---TFTFKIKLNE 437
Cdd:COG2205   162 gdgvRISVSDngpgI--PEEELERIFE-RFyrgdNSRGEGGTGLGLAIVKRIVEAHGGTIWVESEPGggtTFTVTLPLAE 238
ArsS_fam_HK NF038389
ArsS family sensor histidine kinase; ArsS in Helicobacter pylori is a sensor histidine kinase ...
14-432 2.69e-14

ArsS family sensor histidine kinase; ArsS in Helicobacter pylori is a sensor histidine kinase participating in a two-component system that controls the response to acid conditiions encountered during the process of gastric colonization. This HMM identified ArsS itself but also a broader collection of apparent orthologs from closely related non-gastric colonizers such as Helicobacter hepaticus, Campylobacter jejuni and Wolinella succinogenes. See BlastRule NBR014349 for specific identification of ArsS itself, distinguished by a signature His residue that becomes protonated at low pH.


Pssm-ID: 468500 [Multi-domain]  Cd Length: 402  Bit Score: 74.11  E-value: 2.69e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1328117890  14 IFSVLVLFIMIIHLL--VFFMFPKSYLETRKHELTVKANEIAeyldgkdlNYITQSLEFFSSSNDIKAFIKKgvNANELA 91
Cdd:NF038389    4 FFKITILFAIALVSVsaLFLILLKYQKENYNEELNKKYSLIA--------NTLLQLYQKNINEEELEKYLKN--FGFMPI 73
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1328117890  92 IDEGIDVNLNSNTNSLIVEDRAIHSSS-----GVELMINFVSTADMLKEAKSISFKFlPLSVIFSIAVSIIIAFIYAKMI 166
Cdd:NF038389   74 TDKKLEKEILEIGKNKFILKENGSFRIlkyndKIYLLIKNDGFSLLLEDNEKKSYRY-YYIIVFFIFLILLLLILYISVL 152
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1328117890 167 K------HNIGEIKDVTDQMMQLDRqaylKVNSADEIAELKlqiNELYRSLlssiddievknKEIIKLEQMKYDFLRGSS 240
Cdd:NF038389  153 KslkplkKLKKQIKKFANGDFDFIK----SESNGDEIGEVA---NEFDKAV-----------KKIKALNESRQLFLRNIM 214
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1328117890 241 HELKTPLSRMKIILENMKYNigKYKDRDLYIDKCLDI-TNELTyNISQIltfSSLEYLKDDEEwVTIKSVLDAVLvkydE 319
Cdd:NF038389  215 HELKTPITKGRIVAEMLEDE--KQKERLISIFERLESlINEFA-KIEQL---TSKNYKLNKKE-YRLSDIIDEAI----D 283
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1328117890 320 LAMRNHLTFNSTIQSEQLLIGK--KALNLVLSNLISNAVKYSePNSVITIDIKNDWLCVTNMthSEVNLKPLMD-----I 392
Cdd:NF038389  284 MLMIDDSSVIIKVSLEDFKLNVdfELFSLAIKNLIDNAIKYS-PDKKVTIEIKGDKIEFKNK--GEPLEEPLEYyfepfF 360
                         410       420       430       440
                  ....*....|....*....|....*....|....*....|..
gi 1328117890 393 KFDLNKEGSHGLGLYIIKTLLK--NYGIEYAVENTDRTFTFK 432
Cdd:NF038389  361 KGNEKSKSGFGLGLYIVKNILKahGFKLEYEYENGYNIFIIK 402
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
342-435 2.93e-11

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 59.97  E-value: 2.93e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1328117890  342 KALNLVLSNLISNAVKYSEPNSVITIDIK--NDWLCVT--------NMTHSEVNLKPLMDIKFDLNKEGSHGLGLYIIKT 411
Cdd:smart00387   4 DRLRQVLSNLLDNAIKYTPEGGRITVTLErdGDHVEITvedngpgiPPEDLEKIFEPFFRTDKRSRKIGGTGLGLSIVKK 83
                           90       100
                   ....*....|....*....|....*..
gi 1328117890  412 LLKNYGIEYAVENTDR---TFTFKIKL 435
Cdd:smart00387  84 LVELHGGEISVESEPGggtTFTITLPL 110
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
342-435 3.26e-09

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 54.30  E-value: 3.26e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1328117890 342 KALNLVLSNLISNAVKYSEPNSVITIDIK-NDWLCVT---NMTHSEVNLKPLMDIKF---DLNKEGSHGLGLYIIKTLLK 414
Cdd:pfam02518   4 LRLRQVLSNLLDNALKHAAKAGEITVTLSeGGELTLTvedNGIGIPPEDLPRIFEPFstaDKRGGGGTGLGLSIVRKLVE 83
                          90       100
                  ....*....|....*....|....
gi 1328117890 415 NYGIEYAVENTDR---TFTFKIKL 435
Cdd:pfam02518  84 LLGGTITVESEPGggtTVTLTLPL 107
HATPase_VanS-like cd16923
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
347-435 1.24e-08

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.


Pssm-ID: 340400 [Multi-domain]  Cd Length: 102  Bit Score: 52.39  E-value: 1.24e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1328117890 347 VLSNLISNAVKYSEPNSVITID--IKNDWLCVT--NMTHSEVNLKP--LMDiKF-----DLNKEGShGLGLYIIKTLLKN 415
Cdd:cd16923     4 VFSNLLSNAIKYSPENTRIYITsfLTDDVVNIMfkNPSSHPLDFKLekLFE-RFyrgdnSRNTEGA-GLGLSIAKAIIEL 81
                          90       100
                  ....*....|....*....|
gi 1328117890 416 YGIEYAVENTDRTFTFKIKL 435
Cdd:cd16923    82 HGGSASAEYDDNHDLFKVRL 101
phoR PRK11006
phosphate regulon sensor histidine kinase PhoR;
227-368 6.40e-06

phosphate regulon sensor histidine kinase PhoR;


Pssm-ID: 182895 [Multi-domain]  Cd Length: 430  Bit Score: 48.08  E-value: 6.40e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1328117890 227 KLEQMKYDFLRGSSHELKTPLSRMKIILENMkynigkyKDRDL---YIDKCLDITNELTYN----ISQILTFSSLEY--L 297
Cdd:PRK11006  199 QLEGARRNFFANVSHELRTPLTVLQGYLEMM-------QDQPLegaLREKALHTMREQTQRmeglVKQLLTLSKIEAapT 271
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1328117890 298 KDDEEWVTIKSVLDAVLVKYDELAMRNH-LTFNStiqSEQLLI--GKKALNLVLSNLISNAVKYSEPNSVITID 368
Cdd:PRK11006  272 IDLNEKVDVPMMLRVLEREAQTLSQGKHtITFEV---DNSLKVfgNEDQLRSAISNLVYNAVNHTPEGTHITVR 342
HAMP COG2770
HAMP domain [Signal transduction mechanisms];
10-356 1.78e-05

HAMP domain [Signal transduction mechanisms];


Pssm-ID: 442051 [Multi-domain]  Cd Length: 631  Bit Score: 47.03  E-value: 1.78e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1328117890  10 MFIQIFSVLVLFIMIIHLLVFFMFPKSYLETRKHELTVKANEIAEYLDGKDLNYITQSLEFFSSSNDIKAFIKKGVNANE 89
Cdd:COG2770    85 VALAALLLALLLLLLLALLLLLAALLLLLLLAALALLLLLLLLLAALLALLLALALLALLLGLAAARLLLAALLALAAAL 164
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1328117890  90 LAIDEGIDVNLNSNTNSLIVEDRAIHSSSGVELMINFVSTADMLKEAKSISfkflpLSVIFSIAVSIIIAFIYAKMIKHN 169
Cdd:COG2770   165 ALALGAGELLLLADLAAAIAALLAALLLLLLGGLLLVVLLEAALAALLLLL-----LLALLALLLALLLALLLARRITRP 239
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1328117890 170 IGEIKDVTDQMMQLDRQAYLKVNSADEIAELKLQINELYRSLLSSIDDIEVKNKEIIKLEQMkyDFLRGSSHELKTPLSR 249
Cdd:COG2770   240 LRRLAEAARRIAAGDLDVRIPVSRKDEIGELARAFNRMADSLRESIEEAEEEEELAEAELAR--LLEALLELLLALLLLL 317
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1328117890 250 MKIILENMKYNIGKYKDRDLYIDKCLDITNELTYNISQILTFSSLEYLKDDEEWVTIKSVLDAVLVKYDELAMRNHLTFN 329
Cdd:COG2770   318 LALLLLAAAALLLELLLLLLLALLLLLLLAADLLLALALAALLLLLALELLLEAELLVLLALEALALEAELAAVLALLAA 397
                         330       340
                  ....*....|....*....|....*..
gi 1328117890 330 STIQSEQLLIGKKALNLVLSNLISNAV 356
Cdd:COG2770   398 LAAALLLLELALEELVLALLALALLAL 424
 
Name Accession Description Interval E-value
KdpD COG2205
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
218-437 3.55e-28

K+-sensing histidine kinase KdpD [Signal transduction mechanisms];


Pssm-ID: 441807 [Multi-domain]  Cd Length: 239  Bit Score: 111.54  E-value: 3.55e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1328117890 218 IEVKNKEIIKLEQMKYDFLRGSSHELKTPLSRMKIILENMKYNIGKYK-DRDLYIDKCLDITNELTYNISQILTFSSLEY 296
Cdd:COG2205     2 LEEALEELEELERLKSEFLANVSHELRTPLTSILGAAELLLDEEDLSPeERRELLEIIRESAERLLRLIEDLLDLSRLES 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1328117890 297 --LKDDEEWVTIKSVLDAVLVKYDELAMRNHLTFNSTIQSEQLLIG--KKALNLVLSNLISNAVKYSEPNSVITIDIKND 372
Cdd:COG2205    82 gkLSLELEPVDLAELLEEAVEELRPLAEEKGIRLELDLPPELPLVYadPELLEQVLANLLDNAIKYSPPGGTITISARRE 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1328117890 373 ----WLCVTN----MthSEVNLKPLMDiKF----DLNKEGSHGLGLYIIKTLLKNYGIEYAVENTDR---TFTFKIKLNE 437
Cdd:COG2205   162 gdgvRISVSDngpgI--PEEELERIFE-RFyrgdNSRGEGGTGLGLAIVKRIVEAHGGTIWVESEPGggtTFTVTLPLAE 238
BaeS COG0642
Signal transduction histidine kinase [Signal transduction mechanisms];
194-436 4.88e-24

Signal transduction histidine kinase [Signal transduction mechanisms];


Pssm-ID: 440407 [Multi-domain]  Cd Length: 328  Bit Score: 101.91  E-value: 4.88e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1328117890 194 ADEIAELKLQINELYRSLLSSIDDIEVKNKEIIKLEQMKYDFLRGSSHELKTPLSRMKIILENMKYNIGKykDRDLYIDK 273
Cdd:COG0642    72 LLLLLLLLLLLLLLLLLLLLLLLLLLALLLLLEEANEAKSRFLANVSHELRTPLTAIRGYLELLLEELDE--EQREYLET 149
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1328117890 274 CLDITNELTYNISQILTFSSLE--YLKDDEEWVTIKSVLDAVLVKYDELAMRNHLTFNSTIQSEQLLI--GKKALNLVLS 349
Cdd:COG0642   150 ILRSADRLLRLINDLLDLSRLEagKLELEPEPVDLAELLEEVVELFRPLAEEKGIELELDLPDDLPTVrgDPDRLRQVLL 229
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1328117890 350 NLISNAVKYSEPNSVITIDIKND----WLCVTN----MTHSEVN--LKPLMDIKFDLNKEGShGLGLYIIKTLLKNYGIE 419
Cdd:COG0642   230 NLLSNAIKYTPEGGTVTVSVRREgdrvRISVEDtgpgIPPEDLEriFEPFFRTDPSRRGGGT-GLGLAIVKRIVELHGGT 308
                         250       260
                  ....*....|....*....|
gi 1328117890 420 YAVENTDR---TFTFKIKLN 436
Cdd:COG0642   309 IEVESEPGkgtTFTVTLPLA 328
WalK COG5002
Sensor histidine kinase WalK [Signal transduction mechanisms];
100-437 1.40e-23

Sensor histidine kinase WalK [Signal transduction mechanisms];


Pssm-ID: 444026 [Multi-domain]  Cd Length: 390  Bit Score: 101.55  E-value: 1.40e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1328117890 100 LNSNTNSLIVEDRAIHSSSGVELMINFVSTADMLKEAKSISFKFLPLSVIFSIAVSIIIAFIYAKMIKHNIGEIKDVTDQ 179
Cdd:COG5002    39 LLLLLLLLLLLLLLALLLLLLLLLLLLLALLLLLLLLLLLLALALLLLALLLLLLLLLLLLALLILLLLLALLILLAALL 118
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1328117890 180 MMQLDRQAYLKVNSADEIAELKLQINELYRSLLSSidDIEvknkEIIKLEQMKYDFLRGSSHELKTPLSRMKIILENMKY 259
Cdd:COG5002   119 LLLSELLLLLLLLGRLSLRLSALLLGLLLLAAVER--DIT----ELERLEQMRREFVANVSHELRTPLTSIRGYLELLLD 192
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1328117890 260 NIGK-YKDRDLYIDKCLDITNELTYNISQILTFSSLEY--LKDDEEWVTIKSVLDAVLVKYDELAMRNHLTFNSTIQSEQ 336
Cdd:COG5002   193 GAADdPEERREYLEIILEEAERLSRLVNDLLDLSRLESgeLKLEKEPVDLAELLEEVVEELRPLAEEKGIELELDLPEDP 272
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1328117890 337 LLI--GKKALNLVLSNLISNAVKYSEPNSVITIDIKND----WLCVTNmtH----SEVNLKPLMDiKF-------DLNKE 399
Cdd:COG5002   273 LLVlgDPDRLEQVLTNLLDNAIKYTPEGGTITVSLREEddqvRISVRD--TgigiPEEDLPRIFE-RFyrvdksrSRETG 349
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|.
gi 1328117890 400 GShGLGLYIIKTLLKNYGIEYAVENTDR---TFTFKIKLNE 437
Cdd:COG5002   350 GT-GLGLAIVKHIVEAHGGRIWVESEPGkgtTFTITLPLAR 389
ArsS_fam_HK NF038389
ArsS family sensor histidine kinase; ArsS in Helicobacter pylori is a sensor histidine kinase ...
14-432 2.69e-14

ArsS family sensor histidine kinase; ArsS in Helicobacter pylori is a sensor histidine kinase participating in a two-component system that controls the response to acid conditiions encountered during the process of gastric colonization. This HMM identified ArsS itself but also a broader collection of apparent orthologs from closely related non-gastric colonizers such as Helicobacter hepaticus, Campylobacter jejuni and Wolinella succinogenes. See BlastRule NBR014349 for specific identification of ArsS itself, distinguished by a signature His residue that becomes protonated at low pH.


Pssm-ID: 468500 [Multi-domain]  Cd Length: 402  Bit Score: 74.11  E-value: 2.69e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1328117890  14 IFSVLVLFIMIIHLL--VFFMFPKSYLETRKHELTVKANEIAeyldgkdlNYITQSLEFFSSSNDIKAFIKKgvNANELA 91
Cdd:NF038389    4 FFKITILFAIALVSVsaLFLILLKYQKENYNEELNKKYSLIA--------NTLLQLYQKNINEEELEKYLKN--FGFMPI 73
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1328117890  92 IDEGIDVNLNSNTNSLIVEDRAIHSSS-----GVELMINFVSTADMLKEAKSISFKFlPLSVIFSIAVSIIIAFIYAKMI 166
Cdd:NF038389   74 TDKKLEKEILEIGKNKFILKENGSFRIlkyndKIYLLIKNDGFSLLLEDNEKKSYRY-YYIIVFFIFLILLLLILYISVL 152
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1328117890 167 K------HNIGEIKDVTDQMMQLDRqaylKVNSADEIAELKlqiNELYRSLlssiddievknKEIIKLEQMKYDFLRGSS 240
Cdd:NF038389  153 KslkplkKLKKQIKKFANGDFDFIK----SESNGDEIGEVA---NEFDKAV-----------KKIKALNESRQLFLRNIM 214
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1328117890 241 HELKTPLSRMKIILENMKYNigKYKDRDLYIDKCLDI-TNELTyNISQIltfSSLEYLKDDEEwVTIKSVLDAVLvkydE 319
Cdd:NF038389  215 HELKTPITKGRIVAEMLEDE--KQKERLISIFERLESlINEFA-KIEQL---TSKNYKLNKKE-YRLSDIIDEAI----D 283
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1328117890 320 LAMRNHLTFNSTIQSEQLLIGK--KALNLVLSNLISNAVKYSePNSVITIDIKNDWLCVTNMthSEVNLKPLMD-----I 392
Cdd:NF038389  284 MLMIDDSSVIIKVSLEDFKLNVdfELFSLAIKNLIDNAIKYS-PDKKVTIEIKGDKIEFKNK--GEPLEEPLEYyfepfF 360
                         410       420       430       440
                  ....*....|....*....|....*....|....*....|..
gi 1328117890 393 KFDLNKEGSHGLGLYIIKTLLK--NYGIEYAVENTDRTFTFK 432
Cdd:NF038389  361 KGNEKSKSGFGLGLYIVKNILKahGFKLEYEYENGYNIFIIK 402
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
342-435 2.93e-11

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 59.97  E-value: 2.93e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1328117890  342 KALNLVLSNLISNAVKYSEPNSVITIDIK--NDWLCVT--------NMTHSEVNLKPLMDIKFDLNKEGSHGLGLYIIKT 411
Cdd:smart00387   4 DRLRQVLSNLLDNAIKYTPEGGRITVTLErdGDHVEITvedngpgiPPEDLEKIFEPFFRTDKRSRKIGGTGLGLSIVKK 83
                           90       100
                   ....*....|....*....|....*..
gi 1328117890  412 LLKNYGIEYAVENTDR---TFTFKIKL 435
Cdd:smart00387  84 LVELHGGEISVESEPGggtTFTITLPL 110
COG4251 COG4251
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ...
11-437 3.70e-11

Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];


Pssm-ID: 443393 [Multi-domain]  Cd Length: 503  Bit Score: 64.81  E-value: 3.70e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1328117890  11 FIQIFSVLVLFIMIIHLLVFFMFPKSYLETRKHELTVKANEIAEYLDGKDLNYITQSLEFFSSSNDIKAFIKKGVNANEL 90
Cdd:COG4251    68 LLLLLLVLAALALLLLLLLLELALVLLALLLVLLLLLALLLLLALLLLLELLLLLLALLLLLLLLALLLLEELALLRLAL 147
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1328117890  91 AIDEGIDVNLNSNTNSLIVEDRAIHSSSGVELMINFVSTADMLKEAKSISFKFLPLSVIFSIAVSIIIAFIYAKMIKHNI 170
Cdd:COG4251   148 ALLLLLLLLLLLLLLLLALILALLLAALAELELLLLLLLVLLLLLLLLLLLLLLLLRLLLELLLLLEAELLLSLGGGLGL 227
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1328117890 171 GEIKDVTDQMMQLDRQAYLKVNSADEIAELKLQINELYRSLLSSIDDIEVKNKEiikLEQmkydFLRGSSHELKTPLSRM 250
Cdd:COG4251   228 LLLLLLLLVLLLLLILLLLLLILVLELLELRLELEELEEELEERTAELERSNEE---LEQ----FAYVASHDLREPLRKI 300
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1328117890 251 ----KIILEnmkynigKYKDR-----DLYIDKCLDITNELTYNISQILTFSSLEYLKDDEEWVTIKSVLDAVLvkyDELA 321
Cdd:COG4251   301 sgfsQLLEE-------DYGDKldeegREYLERIRDAAERMQALIDDLLAYSRVGRQELEFEPVDLNELLEEVL---EDLE 370
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1328117890 322 MRNHLTfNSTIQSEQL--LIG-KKALNLVLSNLISNAVKYSEPNSVITIDI-----KNDW-LCVT------NMTHSEvnl 386
Cdd:COG4251   371 PRIEER-GAEIEVGPLptVRGdPTLLRQVFQNLISNAIKYSRPGEPPRIEIgaereGGEWvFSVRdngigiDPEYAE--- 446
                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1328117890 387 kplmDIkFDL-------NKEGSHGLGLYIIKTLLKNYGIEYAVENTDR---TFTFKIKLNE 437
Cdd:COG4251   447 ----KI-FEIfqrlhsrDEYEGTGIGLAIVKKIVERHGGRIWVESEPGegaTFYFTLPKAP 502
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
342-435 3.26e-09

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 54.30  E-value: 3.26e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1328117890 342 KALNLVLSNLISNAVKYSEPNSVITIDIK-NDWLCVT---NMTHSEVNLKPLMDIKF---DLNKEGSHGLGLYIIKTLLK 414
Cdd:pfam02518   4 LRLRQVLSNLLDNALKHAAKAGEITVTLSeGGELTLTvedNGIGIPPEDLPRIFEPFstaDKRGGGGTGLGLSIVRKLVE 83
                          90       100
                  ....*....|....*....|....
gi 1328117890 415 NYGIEYAVENTDR---TFTFKIKL 435
Cdd:pfam02518  84 LLGGTITVESEPGggtTVTLTLPL 107
HATPase_VanS-like cd16923
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
347-435 1.24e-08

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.


Pssm-ID: 340400 [Multi-domain]  Cd Length: 102  Bit Score: 52.39  E-value: 1.24e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1328117890 347 VLSNLISNAVKYSEPNSVITID--IKNDWLCVT--NMTHSEVNLKP--LMDiKF-----DLNKEGShGLGLYIIKTLLKN 415
Cdd:cd16923     4 VFSNLLSNAIKYSPENTRIYITsfLTDDVVNIMfkNPSSHPLDFKLekLFE-RFyrgdnSRNTEGA-GLGLSIAKAIIEL 81
                          90       100
                  ....*....|....*....|
gi 1328117890 416 YGIEYAVENTDRTFTFKIKL 435
Cdd:cd16923    82 HGGSASAEYDDNHDLFKVRL 101
HATPase_AgrC-ComD-like cd16935
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
309-435 1.77e-08

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Staphylococcus aureus AgrC and Streptococcus pneumoniae ComD which are involved in quorum sensing; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) including Staphylococcus aureus AgrC which is an HK of the accessory gene regulator (agr) quorum sensing two-component regulatory system (TCS) AgrC-AgrA. The agr system plays a part in the transition from persistent to virulent phenotype. This family also includes Streptococcus pneumoniae ComD HK of the ComD-ComE TCS, involved in quorum sensing and genetic competence.


Pssm-ID: 340412 [Multi-domain]  Cd Length: 134  Bit Score: 52.96  E-value: 1.77e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1328117890 309 VLDAVLVKYDELAMRNHLTFNSTIQSEQLLiGKKALNL--VLSNLISNAV----KYSEPNSVI--TIDIKNDWLCVTNMT 380
Cdd:cd16935     1 ALDSLLSEKLELAREKGIEFTIEIDIPILL-PISPLDLciIFGNLLDNAIeacaKIDKENRFIhlKIRQKKGFLIISIEN 79
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1328117890 381 HSEVNLKPLMDIKFDLNKEGSHGLGLYIIKTLLKNYGIEYAVENTDRTFTFKIKL 435
Cdd:cd16935    80 SYEGELKKKNGLFLSTKKDKNHGIGLKSIREIVKKYNGNLSIEYENGIFTLSILL 134
CitA COG3290
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ...
212-435 5.12e-07

Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];


Pssm-ID: 442519 [Multi-domain]  Cd Length: 389  Bit Score: 51.39  E-value: 5.12e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1328117890 212 LSSIDDIEVKNKEIIKLEQMkYDFLRGSSHELKTplsRMKIILENMkyNIGKYKDRDLYIDKcldITNELtynisQILTF 291
Cdd:COG3290   170 FRDRTELERLEEELEGVKEL-AEALRAQRHDFRN---HLHTISGLL--QLGEYDEALEYIDE---ISEEL-----QELID 235
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1328117890 292 SSLEYLKDdeewvtikSVLDAVLVKYDELAMRNHLTFNSTIQS--EQLLIGKKALNLVLSNLISNAV----KYSEPNSVI 365
Cdd:COG3290   236 SLLSRIGN--------PVLAALLLGKAARARERGIDLTIDIDSdlPDLPLSDTDLVTILGNLLDNAIeaveKLPEEERRV 307
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1328117890 366 TIDI--KNDWLC--VTNmTHSEVNLKPLMDIkFDLN----KEGSHGLGLYIIKTLLKNYGIEYAVENTDRTFT-FKIKL 435
Cdd:COG3290   308 ELSIrdDGDELVieVED-SGPGIPEELLEKI-FERGfstkLGEGRGLGLALVKQIVEKYGGTIEVESEEGEGTvFTVRL 384
HisKA cd00082
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ...
229-292 1.02e-06

Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.


Pssm-ID: 119399 [Multi-domain]  Cd Length: 65  Bit Score: 45.67  E-value: 1.02e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1328117890 229 EQMKYDFLRGSSHELKTPLSRMKIILENMKYNIGKYKDRDLYIDKCLDITNELTYNISQILTFS 292
Cdd:cd00082     1 LQAKGEFLANVSHELRTPLTAIRGALELLEEELLDDEEQREYLERIREEAERLLRLINDLLDLS 64
phoR PRK11006
phosphate regulon sensor histidine kinase PhoR;
227-368 6.40e-06

phosphate regulon sensor histidine kinase PhoR;


Pssm-ID: 182895 [Multi-domain]  Cd Length: 430  Bit Score: 48.08  E-value: 6.40e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1328117890 227 KLEQMKYDFLRGSSHELKTPLSRMKIILENMkynigkyKDRDL---YIDKCLDITNELTYN----ISQILTFSSLEY--L 297
Cdd:PRK11006  199 QLEGARRNFFANVSHELRTPLTVLQGYLEMM-------QDQPLegaLREKALHTMREQTQRmeglVKQLLTLSKIEAapT 271
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1328117890 298 KDDEEWVTIKSVLDAVLVKYDELAMRNH-LTFNStiqSEQLLI--GKKALNLVLSNLISNAVKYSEPNSVITID 368
Cdd:PRK11006  272 IDLNEKVDVPMMLRVLEREAQTLSQGKHtITFEV---DNSLKVfgNEDQLRSAISNLVYNAVNHTPEGTHITVR 342
HAMP COG2770
HAMP domain [Signal transduction mechanisms];
10-356 1.78e-05

HAMP domain [Signal transduction mechanisms];


Pssm-ID: 442051 [Multi-domain]  Cd Length: 631  Bit Score: 47.03  E-value: 1.78e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1328117890  10 MFIQIFSVLVLFIMIIHLLVFFMFPKSYLETRKHELTVKANEIAEYLDGKDLNYITQSLEFFSSSNDIKAFIKKGVNANE 89
Cdd:COG2770    85 VALAALLLALLLLLLLALLLLLAALLLLLLLAALALLLLLLLLLAALLALLLALALLALLLGLAAARLLLAALLALAAAL 164
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1328117890  90 LAIDEGIDVNLNSNTNSLIVEDRAIHSSSGVELMINFVSTADMLKEAKSISfkflpLSVIFSIAVSIIIAFIYAKMIKHN 169
Cdd:COG2770   165 ALALGAGELLLLADLAAAIAALLAALLLLLLGGLLLVVLLEAALAALLLLL-----LLALLALLLALLLALLLARRITRP 239
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1328117890 170 IGEIKDVTDQMMQLDRQAYLKVNSADEIAELKLQINELYRSLLSSIDDIEVKNKEIIKLEQMkyDFLRGSSHELKTPLSR 249
Cdd:COG2770   240 LRRLAEAARRIAAGDLDVRIPVSRKDEIGELARAFNRMADSLRESIEEAEEEEELAEAELAR--LLEALLELLLALLLLL 317
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1328117890 250 MKIILENMKYNIGKYKDRDLYIDKCLDITNELTYNISQILTFSSLEYLKDDEEWVTIKSVLDAVLVKYDELAMRNHLTFN 329
Cdd:COG2770   318 LALLLLAAAALLLELLLLLLLALLLLLLLAADLLLALALAALLLLLALELLLEAELLVLLALEALALEAELAAVLALLAA 397
                         330       340
                  ....*....|....*....|....*..
gi 1328117890 330 STIQSEQLLIGKKALNLVLSNLISNAV 356
Cdd:COG2770   398 LAAALLLLELALEELVLALLALALLAL 424
PRK09959 PRK09959
acid-sensing system histidine kinase EvgS;
215-433 4.57e-05

acid-sensing system histidine kinase EvgS;


Pssm-ID: 182169 [Multi-domain]  Cd Length: 1197  Bit Score: 45.88  E-value: 4.57e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1328117890  215 IDDIEVKNKEIIKLEQMKYDFLRGSSHELKTPLSRMKIILENMKYNIGKYKDRDLYIDKCLDITNELTYNISQILTFSSL 294
Cdd:PRK09959   695 IHALEVERNKAINATVAKSQFLATMSHEIRTPISSIMGFLELLSGSGLSKEQRVEAISLAYATGQSLLGLIGEILDVDKI 774
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1328117890  295 EY--LKDDEEWVTIKSVLDAVLVKYDELAMRNH--LTFNSTIQSEQLL-IGKKALNLVLSNLISNAVKYSEPNSV-ITID 368
Cdd:PRK09959   775 ESgnYQLQPQWVDIPTLVQNTCHSFGAIAASKSiaLSCSSTFPDHYLVkIDPQAFKQVLSNLLSNALKFTTEGAVkITTS 854
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1328117890  369 IK--NDWLCVTNMThsevnlkpLMDIKFDLNKEGSH------------------GLGLYIIKTLLKNYGIEYAVEN---T 425
Cdd:PRK09959   855 LGhiDDNHAVIKMT--------IMDSGSGLSQEEQQqlfkrysqtsagrqqtgsGLGLMICKELIKNMQGDLSLEShpgI 926

                   ....*...
gi 1328117890  426 DRTFTFKI 433
Cdd:PRK09959   927 GTTFTITI 934
HATPase_BceS-YxdK-YvcQ-like cd16948
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
341-432 8.23e-05

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.


Pssm-ID: 340424 [Multi-domain]  Cd Length: 109  Bit Score: 41.50  E-value: 8.23e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1328117890 341 KKALNLVLSNLISNAVKYSEPNSVITIDIKND----WLCV--TNMTHSEVNLKPLMDIKF----DLNKEGSHGLGLYIIK 410
Cdd:cd16948     3 AKWLSFIIGQIVSNALKYSKQGGKIEIYSETNeqgvVLSIkdFGIGIPEEDLPRVFDKGFtgenGRNFQESTGMGLYLVK 82
                          90       100
                  ....*....|....*....|....*..
gi 1328117890 411 TLLKNYGIEYAVEN-----TDRTFTFK 432
Cdd:cd16948    83 KLCDKLGHKIDVESevgegTTFTITFP 109
NtrY COG5000
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ...
175-377 3.02e-04

Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];


Pssm-ID: 444024 [Multi-domain]  Cd Length: 422  Bit Score: 43.03  E-value: 3.02e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1328117890 175 DVTDQMMQLDRQAYLKVNSADEIaELKLQINELY-RSLLSSIDDIEvknkEIIKLEQMK--YDFLRGSSHELKTPLSRMK 251
Cdd:COG5000   146 ELLREALERGWQEEIELTRDGRR-TLLVRASPLRdDGYVIVFDDIT----ELLRAERLAawGELARRIAHEIKNPLTPIQ 220
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1328117890 252 IILENMKYNIGKYKDRDL-YIDKCLDITNELTYNISQI----LTFSSLEYLKDdeEWVTIKSVLDAVLVKYDELAMRNHL 326
Cdd:COG5000   221 LSAERLRRKLADKLEEDReDLERALDTIIRQVDRLKRIvdefLDFARLPEPQL--EPVDLNELLREVLALYEPALKEKDI 298
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1328117890 327 TFNSTIQSEQLLI--GKKALNLVLSNLISNAVKYSEPNSVITIDIK--NDWLCVT 377
Cdd:COG5000   299 RLELDLDPDLPEVlaDRDQLEQVLINLLKNAIEAIEEGGEIEVSTRreDGRVRIE 353
HATPase_c_5 pfam14501
GHKL domain; This family represents the structurally related ATPase domains of histidine ...
347-435 4.78e-04

GHKL domain; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 433996 [Multi-domain]  Cd Length: 102  Bit Score: 39.12  E-value: 4.78e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1328117890 347 VLSNLISNA---VKYSEPNSVI--TIDIKNDWLCVTNMTHSEVNLKPLMDIKFDLNKEGSHGLGLYIIKTLLKNYGIEYA 421
Cdd:pfam14501   9 IFGNLLDNAieaCSKIDDNRFIrlKIREKQNFLIIRIENTYEGELKFEGKLPSTKTKGDGHGIGLKSIRRIVKKYGGNLS 88
                          90
                  ....*....|....
gi 1328117890 422 VENTDRTFTFKIKL 435
Cdd:pfam14501  89 TEIENGIFTLSILL 102
Tar COG0840
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];
1-218 4.98e-04

Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];


Pssm-ID: 440602 [Multi-domain]  Cd Length: 533  Bit Score: 42.31  E-value: 4.98e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1328117890   1 MKKLKIFPKMFIQIFSVLVLFIMIIHLLVFFMFPKSYLETRKHELTVKANEIAEYLDGKDLNYITQSLEFFSSSNDIKAF 80
Cdd:COG0840    38 AALTALALLLLLSLLALLLLLLLLALALLLVLLALLLLLALVVLLALLLALLLLLLALLALALAALALLAALAALLALLE 117
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1328117890  81 IKKGVNANELAIDEGIDVNLNSNTNSLIVEDRA---IHSSSGVELMINFVSTADMLKEAKSISFKFLPLSVIFSIAVSII 157
Cdd:COG0840   118 LLLAALLAALAIALLALAALLALAALALALLALallAAAAAAAAALAALLEAAALALAAAALALALLAAALLALVALAII 197
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1328117890 158 IAFIYAKMIKHNIGEIKDVTDQMMQLDRQAYLKVNSADEIAELKLQINELYRSLLSSIDDI 218
Cdd:COG0840   198 LALLLSRSITRPLRELLEVLERIAEGDLTVRIDVDSKDEIGQLADAFNRMIENLRELVGQV 258
HATPase_SpaK_NisK-like cd16975
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
343-425 5.12e-04

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.


Pssm-ID: 340434 [Multi-domain]  Cd Length: 107  Bit Score: 39.37  E-value: 5.12e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1328117890 343 ALNLVLSNLISNAVKYSEPNSVITIDIKNDWLC----VTNMTH--SEVNLKPLMDIKF---DLNKEGSH-GLGLYIIKTL 412
Cdd:cd16975     4 LLSRALINIISNACQYAPEGGTVSISIYDEEEYlyfeIWDNGHgfSEQDLKKALELFYrddTSRRSGGHyGMGLYIAKNL 83
                          90
                  ....*....|...
gi 1328117890 413 LKNYGIEYAVENT 425
Cdd:cd16975    84 VEKHGGSLIIENS 96
PRK10549 PRK10549
two-component system sensor histidine kinase BaeS;
190-255 5.54e-04

two-component system sensor histidine kinase BaeS;


Pssm-ID: 182539 [Multi-domain]  Cd Length: 466  Bit Score: 41.93  E-value: 5.54e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1328117890 190 KVNSADEIAELKLQINELYRSLlssiddiEvKNkeiiklEQMKYDFLRGSSHELKTPLSRMKIILE 255
Cdd:PRK10549  212 TPTSRDELGRLAQDFNQLASTL-------E-KN------EQMRRDFMADISHELRTPLAVLRGELE 263
PRK10337 PRK10337
sensor protein QseC; Provisional
235-378 6.52e-04

sensor protein QseC; Provisional


Pssm-ID: 182388 [Multi-domain]  Cd Length: 449  Bit Score: 41.94  E-value: 6.52e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1328117890 235 FLRGSSHELKTPLSRMKIILENMKYNIGKYKDRD---LYIDKCLDITNELtynISQILTFSSLEYLK--DDEEWVTIKSV 309
Cdd:PRK10337  240 FTSDAAHELRSPLAALKVQTEVAQLSDDDPQARKkalLQLHAGIDRATRL---VDQLLTLSRLDSLDnlQDVAEIPLEDL 316
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1328117890 310 LDAVLVKYDELA------MRNHLTFNSTIQSEQLLIgkkaLNLVLSNLISNAVKYSEPNSVITIDIKNDWLCVTN 378
Cdd:PRK10337  317 LQSAVMDIYHTAqqagidVRLTLNAHPVIRTGQPLL----LSLLVRNLLDNAIRYSPQGSVVDVTLNARNFTVRD 387
HisKA smart00388
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ...
231-295 8.21e-04

His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.


Pssm-ID: 214644 [Multi-domain]  Cd Length: 66  Bit Score: 37.55  E-value: 8.21e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1328117890  231 MKYDFLRGSSHELKTPLSRMKIILENMKYNIGKYKDRDL--YIDKCLDITNELtynISQILTFSSLE 295
Cdd:smart00388   1 AKREFLANLSHELRTPLTAIRGYLELLLDTELSEEQREYleTILREAERLLRL---INDLLDLSRIE 64
HisKA pfam00512
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ...
231-295 1.33e-03

His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.


Pssm-ID: 459839 [Multi-domain]  Cd Length: 66  Bit Score: 37.19  E-value: 1.33e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1328117890 231 MKYDFLRGSSHELKTPLSRMKIILENMKyNIGKYKDRDLYIDKCLDITNELTYNISQILTFSSLE 295
Cdd:pfam00512   1 AKSEFLANLSHELRTPLTAIRGYLELLR-DEKLDEEQREYLETILRSAERLLRLINDLLDLSRIE 64
PRK11100 PRK11100
sensory histidine kinase CreC; Provisional
241-368 3.39e-03

sensory histidine kinase CreC; Provisional


Pssm-ID: 236846 [Multi-domain]  Cd Length: 475  Bit Score: 39.44  E-value: 3.39e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1328117890 241 HELKTPLSRMK----IILENMKYnigkyKDRDLYIDKCLDITNELTYNISQILTFSSLEYLK--DDEEWVTIKSVLDAVL 314
Cdd:PRK11100  265 HELKSPLAAIRgaaeLLQEDPPP-----EDRARFTGNILTQSARLQQLIDRLLELARLEQRQelEVLEPVALAALLEELV 339
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1328117890 315 VKYDELAMRNHLTF-----NSTIQSEQLLigkkaLNLVLSNLISNAVKYSEPNSVITID 368
Cdd:PRK11100  340 EAREAQAAAKGITLrlrpdDARVLGDPFL-----LRQALGNLLDNAIDFSPEGGTITLS 393
NtrY COG5000
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ...
144-219 4.79e-03

Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];


Pssm-ID: 444024 [Multi-domain]  Cd Length: 422  Bit Score: 39.17  E-value: 4.79e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1328117890 144 LPLSVIFSIAVSIIIAFIYAKMIKHNIGEIKDVTDQMMQLDRQAYLKVNSADEIAELKLQINELYRSLLSSIDDIE 219
Cdd:COG5000    11 LLLIALLLLLLALWLALLLARRLTRPLRRLAEATRAVAAGDLSVRLPVTGDDEIGELARAFNRMTDQLKEQREELE 86
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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