pilus (MSHA type) biogenesis protein MshL; Members of this family are predicted secretins, ...
239-524
6.14e-97
pilus (MSHA type) biogenesis protein MshL; Members of this family are predicted secretins, that is, outer membrane pore proteins associated with delivery of proteins from periplasm to the outside of the cell. Related families include GspD of type II secretion (TIGR02517), the YscC/HrcC family from type III secretion (TIGR02516), and the PilQ secretin of type IV pilus formation (TIGR02515). Members of this family are found in gene clusters associated with MSHA (mannose-sensitive hemagglutinin) and related pili, and appear to be the secretin of this pilus system. [Cell envelope, Surface structures]
The actual alignment was detected with superfamily member TIGR02519:
Pssm-ID: 274176 [Multi-domain] Cd Length: 290 Bit Score: 296.22 E-value: 6.14e-97
Secretin N-terminal domain; This is a short domain found in bacterial type II/III secretory ...
146-245
4.30e-14
Secretin N-terminal domain; This is a short domain found in bacterial type II/III secretory system proteins. The architecture of these proteins suggest that this family may be functionally analogous to pfam03958.
:
Pssm-ID: 429577 Cd Length: 91 Bit Score: 67.68 E-value: 4.30e-14
pilus (MSHA type) biogenesis protein MshL; Members of this family are predicted secretins, ...
239-524
6.14e-97
pilus (MSHA type) biogenesis protein MshL; Members of this family are predicted secretins, that is, outer membrane pore proteins associated with delivery of proteins from periplasm to the outside of the cell. Related families include GspD of type II secretion (TIGR02517), the YscC/HrcC family from type III secretion (TIGR02516), and the PilQ secretin of type IV pilus formation (TIGR02515). Members of this family are found in gene clusters associated with MSHA (mannose-sensitive hemagglutinin) and related pili, and appear to be the secretin of this pilus system. [Cell envelope, Surface structures]
Pssm-ID: 274176 [Multi-domain] Cd Length: 290 Bit Score: 296.22 E-value: 6.14e-97
Secretin N-terminal domain; This is a short domain found in bacterial type II/III secretory ...
146-245
4.30e-14
Secretin N-terminal domain; This is a short domain found in bacterial type II/III secretory system proteins. The architecture of these proteins suggest that this family may be functionally analogous to pfam03958.
Pssm-ID: 429577 Cd Length: 91 Bit Score: 67.68 E-value: 4.30e-14
pilus (MSHA type) biogenesis protein MshL; Members of this family are predicted secretins, ...
239-524
6.14e-97
pilus (MSHA type) biogenesis protein MshL; Members of this family are predicted secretins, that is, outer membrane pore proteins associated with delivery of proteins from periplasm to the outside of the cell. Related families include GspD of type II secretion (TIGR02517), the YscC/HrcC family from type III secretion (TIGR02516), and the PilQ secretin of type IV pilus formation (TIGR02515). Members of this family are found in gene clusters associated with MSHA (mannose-sensitive hemagglutinin) and related pili, and appear to be the secretin of this pilus system. [Cell envelope, Surface structures]
Pssm-ID: 274176 [Multi-domain] Cd Length: 290 Bit Score: 296.22 E-value: 6.14e-97
type II secretion system protein D; In Gram-negative bacteria, proteins that have first ...
246-524
3.13e-44
type II secretion system protein D; In Gram-negative bacteria, proteins that have first crossed the inner member by Sec-dependent protein transport can be exported across the outer membrane by type II secretion, also called the main terminal branch of the general secretion pathway. Members of this family are general secretion pathway protein D. In Yersinia enterocolitica, a second member of this family is part of a novel second type II secretion system specifically associated with virulence (See ). This family is closely homologous to the type IV pilus outer membrane secretin PilQ (TIGR02515) and to the type III secretion system pore YscC/HrcC (TIGR02516). [Protein fate, Protein and peptide secretion and trafficking]
Pssm-ID: 274175 [Multi-domain] Cd Length: 594 Bit Score: 165.25 E-value: 3.13e-44
type IV pilus secretin (or competence protein) PilQ; A number of proteins homologous to PilQ ...
100-525
3.35e-34
type IV pilus secretin (or competence protein) PilQ; A number of proteins homologous to PilQ are involved in type IV pilus formation, competence for transformation, type III secretion, and type II secretion (also called the main terminal branch of the general secretion pathway). Members of this family include PilQ itself, which is a component of the type IV pilus structure, from a number of species. In Haemophilus influenzae, the member of this family is associated with competence for transformation with exogenous DNA rather than with formation of a type IV pilus; the surface structure required for competence may be considered an unusual, incomplete type IV pilus structure. [Cell envelope, Surface structures]
Pssm-ID: 274173 [Multi-domain] Cd Length: 418 Bit Score: 133.98 E-value: 3.35e-34
type III secretion outer membrane pore, YscC/HrcC family; A number of proteins homologous to ...
232-525
2.83e-20
type III secretion outer membrane pore, YscC/HrcC family; A number of proteins homologous to the type IV pilus secretin PilQ (TIGR02515) are involved in type IV pilus formation, competence for transformation, type III secretion, and type II secretion (also called the main terminal branch of the general secretion pathway). The clade described by this model contains the outer membrane pore proteins of bacterial type III secretion systems, typified by YscC for animal pathogens and HrcC for plant pathogens. [Protein fate, Protein and peptide secretion and trafficking, Cellular processes, Pathogenesis]
Pssm-ID: 274174 [Multi-domain] Cd Length: 462 Bit Score: 93.59 E-value: 2.83e-20
Secretin N-terminal domain; This is a short domain found in bacterial type II/III secretory ...
146-245
4.30e-14
Secretin N-terminal domain; This is a short domain found in bacterial type II/III secretory system proteins. The architecture of these proteins suggest that this family may be functionally analogous to pfam03958.
Pssm-ID: 429577 Cd Length: 91 Bit Score: 67.68 E-value: 4.30e-14
Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
References:
Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
of the residues that compose this conserved feature have been mapped to the query sequence.
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Functional characterization of the conserved domain architecture found on the query.
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if a domain or superfamily has been annotated with functional sites (conserved features),
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click on the bars or triangles to view your query sequence embedded in a multiple sequence alignment of the proteins used to develop the corresponding domain model.
The table lists conserved domains identified on the query sequence. Click on the plus sign (+) on the left to display full descriptions, alignments, and scores.
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To view your query sequence embedded in that multiple sequence alignment, click on the colored bars in the Graphical Summary portion of the search results page,
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Concise Display shows only the best scoring domain model, in each hit category listed below except non-specific hits, for each region on the query sequence.
(labeled illustration) Standard Display shows only the best scoring domain model from each source, in each hit category listed below for each region on the query sequence.
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(labeled illustration) Four types of hits can be shown, as available,
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and represent a very high confidence that the query sequence belongs to the same protein family as the sequences use to create the domain model
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