NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1330122459|ref|WP_102320163|]
View 

MULTISPECIES: cation:proton antiporter family protein [unclassified Vibrio]

Protein Classification

cation:proton antiporter family protein( domain architecture ID 18082866)

monovalent cation:proton antiporter family protein plays a role in controlling intracellular cation (such as K+ and Na+) and proton concentrations in a pH-dependent manner

CATH:  1.20.1530.20
Gene Ontology:  GO:0015078|GO:0140828
PubMed:  9537504
TCDB:  2.A.37

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
RosB super family cl47355
Predicted Kef-type K+ transport protein, K+/H+ antiporter domain [Inorganic ion transport and ...
 4-503 9.88e-60

Predicted Kef-type K+ transport protein, K+/H+ antiporter domain [Inorganic ion transport and metabolism];


The actual alignment was detected with superfamily member COG4651:

Pssm-ID: 443689 [Multi-domain]  Cd Length: 564  Bit Score: 206.75  E-value: 9.88e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1330122459   4 ILISTAFIAGFIALKCHLPPLVGFLVAGF--GLFAFGFETNDTII-TLADLGVTLLLFTIGLKLDIKTLfsKEIWAGATI 80
Cdd:COG4651    12 LILGLAAVLGLLAQRLRQPPIVGYLLAGVliGPFTPGLVADVELIeQLAEIGVILLLFGVGLEFSLKDL--LAVRKIALP 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1330122459  81 HNLLSTLFFAvaLFGFkflGISSLAAMSVEQIVLLGFALSFSSTVFAVKTLQEKGEMNATYGTLAIGILVMQDIFAVV-- 158
Cdd:COG4651    90 GALLQIALTT--LLGF---GIALLLGWSLGESLVFGLALSLSSTVVLLKLLEDRGELDTLHGRIAVGWLIVQDLAVVLml 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1330122459 159 ----FLTASTGKIPEWYAIALFALPLL--------RPLFYKVLDWVGHG---EMLVLSGIFFALVVGAgLFHLVGVKPDL 223
Cdd:COG4651   165 vllpALAGGGGGLLGTLGLTLLKVALFvalmlvvgRRVIPWLLHRVARTrsrELFLLAVLAICLGVAY-LAALFGLSFAL 243

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1330122459 224 GALVLGMLLAGHPKASELSKSLFNLKELFLVCFFLNIGLSEQPTI---QGFMLAILFLLMLPVKGVLYFLVLNRFKFRVR 300
Cdd:COG4651   244 GAFLAGMVLAESEYSHQAAAELLPLRDAFAVLFFVSVGMLFDPSFlleNPLPVLALLLIVLIGKPLIAFLIVLALGYPLR 323

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1330122459 301 TSLLASLSLFNYSEFGLIVGGLAFKMGWMSGD---ILVAVAIavsLSFLIAAPLNRAGHKLYQQSGKWLKEhaSEKLHRR 377
Cdd:COG4651   324 TALLVGLSLAQIGEFSFILAALGLSLGLLSEEayqLILAVAI---LTIALSPYLIALADPLYARLERRPPL--AARLERD 398

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1330122459 378 DKRIDPGRAQVLILGMGRIGTGAYDELRTRYGKVSLGVEVREEAAHNHRSQGRNVISGDATDPDFWERILDTANVKLVIL 457
Cdd:COG4651   399 RPEESDLVVHVVVVGGGGGGGGLALRLLLRGIVVVVVVDNVEEVVRARRRGGIAGGGGAAADLELLAALLAAAAIAVVAI 478

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*.
gi 1330122459 458 AMPHHQGNQTALEQLKSRNFKGQIAAIAEYPDQLETLKENGVDAAF 503
Cdd:COG4651   479 PAAAAALLLIAAARRALPLLIIIARAARRAEEEELLLAGAVEVVVE 524
 
Name Accession Description Interval E-value
RosB COG4651
Predicted Kef-type K+ transport protein, K+/H+ antiporter domain [Inorganic ion transport and ...
 4-503 9.88e-60

Predicted Kef-type K+ transport protein, K+/H+ antiporter domain [Inorganic ion transport and metabolism];


Pssm-ID: 443689 [Multi-domain]  Cd Length: 564  Bit Score: 206.75  E-value: 9.88e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1330122459   4 ILISTAFIAGFIALKCHLPPLVGFLVAGF--GLFAFGFETNDTII-TLADLGVTLLLFTIGLKLDIKTLfsKEIWAGATI 80
Cdd:COG4651    12 LILGLAAVLGLLAQRLRQPPIVGYLLAGVliGPFTPGLVADVELIeQLAEIGVILLLFGVGLEFSLKDL--LAVRKIALP 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1330122459  81 HNLLSTLFFAvaLFGFkflGISSLAAMSVEQIVLLGFALSFSSTVFAVKTLQEKGEMNATYGTLAIGILVMQDIFAVV-- 158
Cdd:COG4651    90 GALLQIALTT--LLGF---GIALLLGWSLGESLVFGLALSLSSTVVLLKLLEDRGELDTLHGRIAVGWLIVQDLAVVLml 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1330122459 159 ----FLTASTGKIPEWYAIALFALPLL--------RPLFYKVLDWVGHG---EMLVLSGIFFALVVGAgLFHLVGVKPDL 223
Cdd:COG4651   165 vllpALAGGGGGLLGTLGLTLLKVALFvalmlvvgRRVIPWLLHRVARTrsrELFLLAVLAICLGVAY-LAALFGLSFAL 243

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1330122459 224 GALVLGMLLAGHPKASELSKSLFNLKELFLVCFFLNIGLSEQPTI---QGFMLAILFLLMLPVKGVLYFLVLNRFKFRVR 300
Cdd:COG4651   244 GAFLAGMVLAESEYSHQAAAELLPLRDAFAVLFFVSVGMLFDPSFlleNPLPVLALLLIVLIGKPLIAFLIVLALGYPLR 323

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1330122459 301 TSLLASLSLFNYSEFGLIVGGLAFKMGWMSGD---ILVAVAIavsLSFLIAAPLNRAGHKLYQQSGKWLKEhaSEKLHRR 377
Cdd:COG4651   324 TALLVGLSLAQIGEFSFILAALGLSLGLLSEEayqLILAVAI---LTIALSPYLIALADPLYARLERRPPL--AARLERD 398

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1330122459 378 DKRIDPGRAQVLILGMGRIGTGAYDELRTRYGKVSLGVEVREEAAHNHRSQGRNVISGDATDPDFWERILDTANVKLVIL 457
Cdd:COG4651   399 RPEESDLVVHVVVVGGGGGGGGLALRLLLRGIVVVVVVDNVEEVVRARRRGGIAGGGGAAADLELLAALLAAAAIAVVAI 478

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*.
gi 1330122459 458 AMPHHQGNQTALEQLKSRNFKGQIAAIAEYPDQLETLKENGVDAAF 503
Cdd:COG4651   479 PAAAAALLLIAAARRALPLLIIIARAARRAEEEELLLAGAVEVVVE 524
Na_H_Exchanger pfam00999
Sodium/hydrogen exchanger family; Na/H antiporters are key transporters in maintaining the pH ...
 3-348 2.97e-33

Sodium/hydrogen exchanger family; Na/H antiporters are key transporters in maintaining the pH of actively metabolising cells. The molecular mechanisms of antiport are unclear. These antiporters contain 10-12 transmembrane regions (M) at the amino-terminus and a large cytoplasmic region at the carboxyl terminus. The transmembrane regions M3-M12 share identity with other members of the family. The M6 and M7 regions are highly conserved. Thus, this is thought to be the region that is involved in the transport of sodium and hydrogen ions. The cytoplasmic region has little similarity throughout the family.


Pssm-ID: 425982 [Multi-domain]  Cd Length: 377  Bit Score: 130.07  E-value: 2.97e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1330122459   3 LILISTAFIAGFIALKCHLPPLVGFLVAG--FGLFAFGFETNDTII--TLADLGVTLLLFTIGLKLDIKTLfsKEIWAGA 78
Cdd:pfam00999   2 VLLILLALLAPLLARRLKLPPIVGLIIAGilLGPSGLGLISEVDEDleVLSNLGLPPLLFLAGLELDLREL--RKNGGSI 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1330122459  79 TIHNLLSTLFFAVA---LFGFKFLGISSLAAmsveqiVLLGFALSFSSTVFAVKTLQEKGEMNATYGTLAIGILVMQDIF 155
Cdd:pfam00999  80 LLLALLGVLIPFVLiglLLYLLGLGIPLLEA------LLFGAILSATSPVVVLAILKELGRVPERLGTLLLGESVLNDGV 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1330122459 156 AVVFLT---------------ASTGKIPEWYAIALFALPLLRPLFYKVLDWVGHGEMLVLSGIFFALVVGAGLF-HLVGV 219
Cdd:pfam00999 154 AVVLLAvllalaqgvgggsdlGWLLLIFLVVAVGGLLLGLLIGWLLRLITRFTDDDRELEVLLVLLLALLAALLaEALGV 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1330122459 220 KPDLGALVLGMLLAGHPKASELSKSLFNLKE-LFLVCFFLNIGLS-----EQPTIQGFMLAILFLLMLpVKGVLYFLVLN 293
Cdd:pfam00999 234 SGILGAFLAGLVLSEYPFANKLSEKLEPFGYgLFNPLFFVLVGLSldlssLLLSVWILVLLALVAILL-GRFLGVFLLLR 312

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1330122459 294 RFKFRVRTSLLASLSLFNYSEFGLIVGGLAFKMGWMSGDILVAVAIAVSLSFLIA 348
Cdd:pfam00999 313 LLGLSLREALIIGFGGLQRGAVSLALAAIGPLLGIIARELYPLLIVVVLFTVLVQ 367
PRK03562 PRK03562
glutathione-regulated potassium-efflux system protein KefC; Provisional
 3-397 5.20e-24

glutathione-regulated potassium-efflux system protein KefC; Provisional


Pssm-ID: 235131 [Multi-domain]  Cd Length: 621  Bit Score: 105.85  E-value: 5.20e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1330122459   3 LILISTAFIAGFIALKCHLPPLVGFLVAG--FGLFAFGFETN-DTIITLADLGVTLLLFTIGLKLDIKTLFS--KEIWAG 77
Cdd:PRK03562   11 LIYLGAAVLIVPIAVRLGLGSVLGYLIAGciIGPWGLRLVTDvESILHFAEFGVVLMLFVIGLELDPQRLWKlrRSIFGG 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1330122459  78 ATihnlLSTLFFAVALFGFK-FLGISSLAAmsveqiVLLGFALSFSSTVFAVKTLQEKGEMNATYGTLAIGILVMQDI-- 154
Cdd:PRK03562   91 GA----LQMVACGGLLGLFCmLLGLRWQVA------LLIGLGLALSSTAIAMQAMNERNLMVTQMGRSAFAILLFQDIaa 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1330122459 155 ---FAVVFLTASTGKIPEWYAIALFALP--------------LLRPLfykvLDWVGHGEML-VLSGIFFALVVGAG-LFH 215
Cdd:PRK03562  161 iplVAMIPLLAASGASTTLGAFALSALKvagalalvvlggryVTRPA----LRFVARSGLReVFTAVALFLVFGFGlLME 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1330122459 216 LVGVKPDLGALVLGMLLAGHPKASELSKSLFNLKELFLVCFFLNIGLS-------EQPtiqGFMLAILfLLMLPVKGVLY 288
Cdd:PRK03562  237 EVGLSMALGAFLAGVLLASSEYRHALESDIEPFKGLLLGLFFIAVGMSidfgtllENP---LRILILL-LGFLAIKIAML 312

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1330122459 289 FLVLNRFKFRVRTSLLASLSLFNYSEFGLIVGGLAFKMGWMSGDILVAVAIAVSLSFLiAAPLnraghkLYQQSGKWLKE 368
Cdd:PRK03562  313 WLLARPLGVPRKQRRWFAVLLGQGGEFAFVVFGAAQMANVLEPEWAKLLTLAVALSMA-ATPL------LLVLLDRLEQS 385

                         410       420
                  ....*....|....*....|....*....
gi 1330122459 369 HASEKlhRRDKRIDPGRAQVLILGMGRIG 397
Cdd:PRK03562  386 RTEEA--READEIDEQQPRVIIAGFGRFG 412
2a37 TIGR00932
transporter, monovalent cation:proton antiporter-2 (CPA2) family; [Transport and binding ...
 8-263 2.64e-22

transporter, monovalent cation:proton antiporter-2 (CPA2) family; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273348 [Multi-domain]  Cd Length: 273  Bit Score: 96.56  E-value: 2.64e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1330122459   8 TAFIAGFIALKCHLPPLVGFLVAG--FGLFAFGFETNDTII-TLADLGVTLLLFTIGLKLDIKTLFSKEIWAGATIHNLL 84
Cdd:TIGR00932   3 AAVLAVPLSRRLGIPSVLGYLLAGvlIGPSGLGLISNVEGVnHLAEFGVILLMFLIGLELDLERLWKLRKAAFGVGVLQV 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1330122459  85 STLFFAVALFGFKFLGISSLAAmsveqiVLLGFALSFSSTVFAVKTLQEKGEMNATYGTLAIGILVMQDIFAVVFLTA-- 162
Cdd:TIGR00932  83 LVPGVLLGLLLGHLLGLALGAA------VVIGIILALSSTAVVVQVLKERGLLKTPFGQTVLGILLFQDIAVVPLLALlp 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1330122459 163 --STGKIPEWYAIALFALP----------LLRPLFYKVLDWV---GHGEMLVLSGIFfaLVVGAGLF-HLVGVKPDLGAL 226
Cdd:TIGR00932 157 llATSASTEHVALALLLLKvflaflllvlLGRWLLRPVLRLTaelRPSELFTAGSLL--LMFGSAYFaDLLGLSMALGAF 234

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1330122459 227 VLGMLLAGHPKASELSKSLFNLKELFLVCFFLNIGLS 263
Cdd:TIGR00932 235 LAGVVLSESEYRHKLESDLEPIGGVLLPLFFISVGMS 271
 
Name Accession Description Interval E-value
RosB COG4651
Predicted Kef-type K+ transport protein, K+/H+ antiporter domain [Inorganic ion transport and ...
 4-503 9.88e-60

Predicted Kef-type K+ transport protein, K+/H+ antiporter domain [Inorganic ion transport and metabolism];


Pssm-ID: 443689 [Multi-domain]  Cd Length: 564  Bit Score: 206.75  E-value: 9.88e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1330122459   4 ILISTAFIAGFIALKCHLPPLVGFLVAGF--GLFAFGFETNDTII-TLADLGVTLLLFTIGLKLDIKTLfsKEIWAGATI 80
Cdd:COG4651    12 LILGLAAVLGLLAQRLRQPPIVGYLLAGVliGPFTPGLVADVELIeQLAEIGVILLLFGVGLEFSLKDL--LAVRKIALP 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1330122459  81 HNLLSTLFFAvaLFGFkflGISSLAAMSVEQIVLLGFALSFSSTVFAVKTLQEKGEMNATYGTLAIGILVMQDIFAVV-- 158
Cdd:COG4651    90 GALLQIALTT--LLGF---GIALLLGWSLGESLVFGLALSLSSTVVLLKLLEDRGELDTLHGRIAVGWLIVQDLAVVLml 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1330122459 159 ----FLTASTGKIPEWYAIALFALPLL--------RPLFYKVLDWVGHG---EMLVLSGIFFALVVGAgLFHLVGVKPDL 223
Cdd:COG4651   165 vllpALAGGGGGLLGTLGLTLLKVALFvalmlvvgRRVIPWLLHRVARTrsrELFLLAVLAICLGVAY-LAALFGLSFAL 243

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1330122459 224 GALVLGMLLAGHPKASELSKSLFNLKELFLVCFFLNIGLSEQPTI---QGFMLAILFLLMLPVKGVLYFLVLNRFKFRVR 300
Cdd:COG4651   244 GAFLAGMVLAESEYSHQAAAELLPLRDAFAVLFFVSVGMLFDPSFlleNPLPVLALLLIVLIGKPLIAFLIVLALGYPLR 323

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1330122459 301 TSLLASLSLFNYSEFGLIVGGLAFKMGWMSGD---ILVAVAIavsLSFLIAAPLNRAGHKLYQQSGKWLKEhaSEKLHRR 377
Cdd:COG4651   324 TALLVGLSLAQIGEFSFILAALGLSLGLLSEEayqLILAVAI---LTIALSPYLIALADPLYARLERRPPL--AARLERD 398

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1330122459 378 DKRIDPGRAQVLILGMGRIGTGAYDELRTRYGKVSLGVEVREEAAHNHRSQGRNVISGDATDPDFWERILDTANVKLVIL 457
Cdd:COG4651   399 RPEESDLVVHVVVVGGGGGGGGLALRLLLRGIVVVVVVDNVEEVVRARRRGGIAGGGGAAADLELLAALLAAAAIAVVAI 478

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*.
gi 1330122459 458 AMPHHQGNQTALEQLKSRNFKGQIAAIAEYPDQLETLKENGVDAAF 503
Cdd:COG4651   479 PAAAAALLLIAAARRALPLLIIIARAARRAEEEELLLAGAVEVVVE 524
KefB COG0475
Kef-type K+ transport system, membrane component KefB [Inorganic ion transport and metabolism]; ...
 3-360 1.19e-42

Kef-type K+ transport system, membrane component KefB [Inorganic ion transport and metabolism];


Pssm-ID: 440243 [Multi-domain]  Cd Length: 384  Bit Score: 156.46  E-value: 1.19e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1330122459   3 LILISTAFIAGFIALKCHLPPLVGFLVAGF--GLFAFGF-ETNDTIITLADLGVTLLLFTIGLKLDIKTLFS--KEIWAG 77
Cdd:COG0475    10 GLLLLAAVLAGLLARRLGLPSVLGYILAGIllGPSGLGLiEDSEALELLAELGVVLLLFLIGLELDLKRLRKmgRRALGI 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1330122459  78 ATIHNLLSTLFFAVALFgfkFLGISSLAAmsveqiVLLGFALSFSSTVFAVKTLQEKGEMNATYGTLAIGILVMQDIFAV 157
Cdd:COG0475    90 GLLQVLLPFLLGFLLAL---LLGLSLAAA------LFLGAALAATSTAIVLKVLKELGLLKTPLGQLILGVALFDDIAAI 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1330122459 158 VFLTA----------------STGKIPEWYAIALFALPLLRPLFYKVLDWVGHGEMLVLSGIFFALVVgAGLFHLVGVKP 221
Cdd:COG0475   161 LLLALvpalagggsvagslllALLKALLFLALLLLVGRYLLRRLFRLVARTRSRELFLLFALLLVLLA-AALAELLGLSA 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1330122459 222 DLGALVLGMLLAGHPKASELSKSLFNLKELFLVCFFLNIGLSEQPTI---QGFMLAILFLLMLPVKGVLYFLVLNRFKFR 298
Cdd:COG0475   240 ALGAFLAGLVLAESEYRHELEEKIEPFGDLFLPLFFVSVGLSLDLSAllsNPLLALLLVLAAIVGKLLGAYLAARLFGLS 319

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1330122459 299 VRTSLLASLSLFNYSEFGLIVGGLAFKMGWMSGDILVAVAIAVSLSFLIAAPLNRAGHKLYQ 360
Cdd:COG0475   320 RREALRIGLLLAPRGEFALVLASLGLSAGLISPELFAALVLVVLLTTLLTPLLLRLALRLAE 381
Na_H_Exchanger pfam00999
Sodium/hydrogen exchanger family; Na/H antiporters are key transporters in maintaining the pH ...
 3-348 2.97e-33

Sodium/hydrogen exchanger family; Na/H antiporters are key transporters in maintaining the pH of actively metabolising cells. The molecular mechanisms of antiport are unclear. These antiporters contain 10-12 transmembrane regions (M) at the amino-terminus and a large cytoplasmic region at the carboxyl terminus. The transmembrane regions M3-M12 share identity with other members of the family. The M6 and M7 regions are highly conserved. Thus, this is thought to be the region that is involved in the transport of sodium and hydrogen ions. The cytoplasmic region has little similarity throughout the family.


Pssm-ID: 425982 [Multi-domain]  Cd Length: 377  Bit Score: 130.07  E-value: 2.97e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1330122459   3 LILISTAFIAGFIALKCHLPPLVGFLVAG--FGLFAFGFETNDTII--TLADLGVTLLLFTIGLKLDIKTLfsKEIWAGA 78
Cdd:pfam00999   2 VLLILLALLAPLLARRLKLPPIVGLIIAGilLGPSGLGLISEVDEDleVLSNLGLPPLLFLAGLELDLREL--RKNGGSI 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1330122459  79 TIHNLLSTLFFAVA---LFGFKFLGISSLAAmsveqiVLLGFALSFSSTVFAVKTLQEKGEMNATYGTLAIGILVMQDIF 155
Cdd:pfam00999  80 LLLALLGVLIPFVLiglLLYLLGLGIPLLEA------LLFGAILSATSPVVVLAILKELGRVPERLGTLLLGESVLNDGV 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1330122459 156 AVVFLT---------------ASTGKIPEWYAIALFALPLLRPLFYKVLDWVGHGEMLVLSGIFFALVVGAGLF-HLVGV 219
Cdd:pfam00999 154 AVVLLAvllalaqgvgggsdlGWLLLIFLVVAVGGLLLGLLIGWLLRLITRFTDDDRELEVLLVLLLALLAALLaEALGV 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1330122459 220 KPDLGALVLGMLLAGHPKASELSKSLFNLKE-LFLVCFFLNIGLS-----EQPTIQGFMLAILFLLMLpVKGVLYFLVLN 293
Cdd:pfam00999 234 SGILGAFLAGLVLSEYPFANKLSEKLEPFGYgLFNPLFFVLVGLSldlssLLLSVWILVLLALVAILL-GRFLGVFLLLR 312

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1330122459 294 RFKFRVRTSLLASLSLFNYSEFGLIVGGLAFKMGWMSGDILVAVAIAVSLSFLIA 348
Cdd:pfam00999 313 LLGLSLREALIIGFGGLQRGAVSLALAAIGPLLGIIARELYPLLIVVVLFTVLVQ 367
PRK03562 PRK03562
glutathione-regulated potassium-efflux system protein KefC; Provisional
 3-397 5.20e-24

glutathione-regulated potassium-efflux system protein KefC; Provisional


Pssm-ID: 235131 [Multi-domain]  Cd Length: 621  Bit Score: 105.85  E-value: 5.20e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1330122459   3 LILISTAFIAGFIALKCHLPPLVGFLVAG--FGLFAFGFETN-DTIITLADLGVTLLLFTIGLKLDIKTLFS--KEIWAG 77
Cdd:PRK03562   11 LIYLGAAVLIVPIAVRLGLGSVLGYLIAGciIGPWGLRLVTDvESILHFAEFGVVLMLFVIGLELDPQRLWKlrRSIFGG 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1330122459  78 ATihnlLSTLFFAVALFGFK-FLGISSLAAmsveqiVLLGFALSFSSTVFAVKTLQEKGEMNATYGTLAIGILVMQDI-- 154
Cdd:PRK03562   91 GA----LQMVACGGLLGLFCmLLGLRWQVA------LLIGLGLALSSTAIAMQAMNERNLMVTQMGRSAFAILLFQDIaa 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1330122459 155 ---FAVVFLTASTGKIPEWYAIALFALP--------------LLRPLfykvLDWVGHGEML-VLSGIFFALVVGAG-LFH 215
Cdd:PRK03562  161 iplVAMIPLLAASGASTTLGAFALSALKvagalalvvlggryVTRPA----LRFVARSGLReVFTAVALFLVFGFGlLME 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1330122459 216 LVGVKPDLGALVLGMLLAGHPKASELSKSLFNLKELFLVCFFLNIGLS-------EQPtiqGFMLAILfLLMLPVKGVLY 288
Cdd:PRK03562  237 EVGLSMALGAFLAGVLLASSEYRHALESDIEPFKGLLLGLFFIAVGMSidfgtllENP---LRILILL-LGFLAIKIAML 312

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1330122459 289 FLVLNRFKFRVRTSLLASLSLFNYSEFGLIVGGLAFKMGWMSGDILVAVAIAVSLSFLiAAPLnraghkLYQQSGKWLKE 368
Cdd:PRK03562  313 WLLARPLGVPRKQRRWFAVLLGQGGEFAFVVFGAAQMANVLEPEWAKLLTLAVALSMA-ATPL------LLVLLDRLEQS 385

                         410       420
                  ....*....|....*....|....*....
gi 1330122459 369 HASEKlhRRDKRIDPGRAQVLILGMGRIG 397
Cdd:PRK03562  386 RTEEA--READEIDEQQPRVIIAGFGRFG 412
2a37 TIGR00932
transporter, monovalent cation:proton antiporter-2 (CPA2) family; [Transport and binding ...
 8-263 2.64e-22

transporter, monovalent cation:proton antiporter-2 (CPA2) family; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273348 [Multi-domain]  Cd Length: 273  Bit Score: 96.56  E-value: 2.64e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1330122459   8 TAFIAGFIALKCHLPPLVGFLVAG--FGLFAFGFETNDTII-TLADLGVTLLLFTIGLKLDIKTLFSKEIWAGATIHNLL 84
Cdd:TIGR00932   3 AAVLAVPLSRRLGIPSVLGYLLAGvlIGPSGLGLISNVEGVnHLAEFGVILLMFLIGLELDLERLWKLRKAAFGVGVLQV 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1330122459  85 STLFFAVALFGFKFLGISSLAAmsveqiVLLGFALSFSSTVFAVKTLQEKGEMNATYGTLAIGILVMQDIFAVVFLTA-- 162
Cdd:TIGR00932  83 LVPGVLLGLLLGHLLGLALGAA------VVIGIILALSSTAVVVQVLKERGLLKTPFGQTVLGILLFQDIAVVPLLALlp 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1330122459 163 --STGKIPEWYAIALFALP----------LLRPLFYKVLDWV---GHGEMLVLSGIFfaLVVGAGLF-HLVGVKPDLGAL 226
Cdd:TIGR00932 157 llATSASTEHVALALLLLKvflaflllvlLGRWLLRPVLRLTaelRPSELFTAGSLL--LMFGSAYFaDLLGLSMALGAF 234

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1330122459 227 VLGMLLAGHPKASELSKSLFNLKELFLVCFFLNIGLS 263
Cdd:TIGR00932 235 LAGVVLSESEYRHKLESDLEPIGGVLLPLFFISVGMS 271
PRK03659 PRK03659
glutathione-regulated potassium-efflux system protein KefB; Provisional
 3-397 1.69e-21

glutathione-regulated potassium-efflux system protein KefB; Provisional


Pssm-ID: 179625 [Multi-domain]  Cd Length: 601  Bit Score: 98.18  E-value: 1.69e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1330122459   3 LILISTAFIAGFIALKCHLPPLVGFLVAG--FGLFAFGFETN-DTIITLADLGVTLLLFTIGLKLDIKTLFS--KEIWAG 77
Cdd:PRK03659   11 VLFLFAAVVAVPLAQRLGIGAVLGYLLAGiaIGPWGLGFISDvDEILHFSELGVVFLMFIIGLELNPSKLWQlrRSIFGV 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1330122459  78 ATIHNLLSTLFFAVALFgfkFLGISSLAAmsveqiVLLGFALSFSSTVFAVKTLQEKGEMNATYGTLAIGILVMQDIfAV 157
Cdd:PRK03659   91 GAAQVLLSAAVLAGLLM---LTDFSWQAA------VVGGIGLAMSSTAMALQLMREKGMNRSESGQLGFSVLLFQDL-AV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1330122459 158 V-------FLTASTGKIPEWYAIALFALP----------LLRPLFYKVldwVGHGEMLVLSGIFFALVVGAGLF-HLVGV 219
Cdd:PRK03659  161 IpalalvpLLAGSADEHFDWMKIGMKVLAfagmliggryLLRPLFRFI---AASGVREVFTAAALLLVLGSALFmDALGL 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1330122459 220 KPDLGALVLGMLLAGHPKASELSKSLFNLKELFLVCFFLNIGLS-EQPTIQGFMLAILF--LLMLPVKG-VLYFLV-LNR 294
Cdd:PRK03659  238 SMALGTFIAGVLLAESEYRHELEIAIEPFKGLLLGLFFISVGMAlNLGVLYTHLLWVLIsvVVLVAVKGlVLYLLArLYG 317

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1330122459 295 FKFRVRTSLLASLSlfNYSEFGLIVGGLAFKMGWMSGDILVAVAIAVSLSfLIAAPLnraghkLYQQSGKWLK------E 368
Cdd:PRK03659  318 LRSSERMQFAGVLS--QGGEFAFVLFSAASSQRLLQGDQMALLLVVVTLS-MMTTPL------LMKLIDKWLArrlngpE 388

                         410       420
                  ....*....|....*....|....*....
gi 1330122459 369 HASEKLHRRDKridpgRAQVLILGMGRIG 397
Cdd:PRK03659  389 EEDEKPWVEDD-----KPQVIIVGFGRFG 412
PRK10669 PRK10669
putative cation:proton antiport protein; Provisional
 5-500 4.70e-21

putative cation:proton antiport protein; Provisional


Pssm-ID: 182633 [Multi-domain]  Cd Length: 558  Bit Score: 96.71  E-value: 4.70e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1330122459   5 LIST-------AFIAGFIALKCHLPPLVGFLVAGF--GLFAFGFeTNDTIIT--LADLGVTLLLFTIGLKLDIKTLFSKE 73
Cdd:PRK10669    7 LITTivgglvlAFILGMLANRLRISPLVGYLLAGVlaGPFTPGF-VADTKLApeLAELGVILLMFGVGLHFSLKDLMAVK 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1330122459  74 IWA--GATIHNLLSTLFFavalfgfkfLGISSLAAMSVEQIVLLGFALSFSSTVFAVKTLQEKGEMNATYGTLAIGILVM 151
Cdd:PRK10669   86 SIAipGAIAQIAVATLLG---------MALSAVLGWSLMTGIVFGLCLSTASTVVLLRALEERQLIDSQRGQIAIGWLIV 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1330122459 152 QD---IFAVVFLTASTGKIPEWYA----------------IALFALPLLrpLFYKVLDWV-------GHGEMLVLSGIFF 205
Cdd:PRK10669  157 EDlvmVLTLVLLPAVAGMMEQGDVgfatlavdlgitigkvIAFIAIMML--VGRRLVPWIlarsaatGSRELFTLSVLAL 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1330122459 206 ALVVGAGLFHLVGVKPDLGALVLGMLLaghpKASELS----KSLFNLKELFLVCFFLNIG-------LSEQPtiqgfmLA 274
Cdd:PRK10669  235 ALGIAFGAVELFDVSFALGAFFAGMVL----NESELShraaHDTLPLRDAFAVLFFVSVGmlfdpmiLIQQP------LA 304

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1330122459 275 ILFLLMLPV--KGVLYFLVLNRFKFRVRTSLLASLSLFNYSEFGLIVGGLAFKMGWMSGD----ILVAVAIAVSLSFLIA 348
Cdd:PRK10669  305 VLATLAIIVfgKSLAAFFLVRLFGHSRRTALTIAASLAQIGEFAFILAGLGMALNLLPQAgqnlVLAGAILSIMLNPVLF 384

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1330122459 349 APLNRaghklYQQSGKWLKEHASEKLHRRDKRIDPGRA-QVLILGMGRIGTGAYDELRTRyGKVSLGVEVREEAAHNHRS 427
Cdd:PRK10669  385 TLLER-----YLAKTETLEEQTLEEAIEEEKQIPVDICnHALLVGYGRVGSLLGEKLLAA-GIPLVVIETSRTRVDELRE 458

                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1330122459 428 QGRNVISGDATDPDFWERI-LDTANVKLVILAMPHHQGNQTALEQLKSRNFKgqIAAIAEYPDQLETLKENGVD 500
Cdd:PRK10669  459 RGIRAVLGNAANEEIMQLAhLDCARWLLLTIPNGYEAGEIVASAREKRPDIE--IIARAHYDDEVAYITERGAN 530
Kch COG1226
Voltage-gated potassium channel Kch [Inorganic ion transport and metabolism];
270-521 7.26e-21

Voltage-gated potassium channel Kch [Inorganic ion transport and metabolism];


Pssm-ID: 440839 [Multi-domain]  Cd Length: 279  Bit Score: 92.48  E-value: 7.26e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1330122459 270 GFMLAILFLLMLPVKGVLYFLVLNRFKFRVRTSLLASLSLFNYSEFGLIVGGLAFKMGWMSGDILVAVAIAVSLSFLIAA 349
Cdd:COG1226    13 LLLLLLLLLLLLLLLLLLLLLLLLLLAALALAALLLLLLLAGGGGFFLLLLLAAAALLLLLLLAAALLLLLVLLLLLLLL 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1330122459 350 PLNRAGHKLYQQSGKWLKEHASEklhrRDKRIDPGRAQVLILGMGRIGTGAYDELRTRyGKVSLGVEVREEAAHNHRSQG 429
Cdd:COG1226    93 LLLLLLALLLLLLALAAREEEAE----AAEDAIDLEGHVIIAGFGRVGQIVARLLRAE-GIPFVVIDLDPERVEELRRFG 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1330122459 430 RNVISGDATDPDFWERI-LDTAnvKLVILAMPHHQGNQTALEQLKSRNFKGQIAAIAEYPDQLETLKENGVDAAFNIYSE 508
Cdd:COG1226   168 IKVYYGDATRPDVLEAAgIERA--RALVVAIDDPEAALRIVELARELNPDLKIIARARDREHAEELRQAGADEVVRETFE 245

                         250
                  ....*....|...
gi 1330122459 509 AGSGFARHVCEQL 521
Cdd:COG1226   246 SALQLARHALEAL 258
TrkA_N pfam02254
TrkA-N domain; This domain is found in a wide variety of proteins. These proteins include ...
 388-504 1.96e-18

TrkA-N domain; This domain is found in a wide variety of proteins. These proteins include potassium channels, phosphoesterases, and various other transporters. This domain binds to NAD.


Pssm-ID: 426679 [Multi-domain]  Cd Length: 115  Bit Score: 81.03  E-value: 1.96e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1330122459 388 VLILGMGRIGTGAYDELRtRYGKVsLGVEVREEAAHNHRSQGRNVISGDATDPDFWERIlDTANVKLVILAMPHHQGNQT 467
Cdd:pfam02254   1 IIIIGYGRVGRSLAEELS-EGGDV-VVIDKDEERVEELREEGVPVVVGDATDEEVLEEA-GIEEADAVIAATGDDEANIL 77

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1330122459 468 ALEQLKSRNFKGQIAAIAEYPDQLETLKENGVDAAFN 504
Cdd:pfam02254  78 IVLLARELNPDKKIIARANDPEHAELLRRLGADHVIS 114
TrkA COG0569
Trk/Ktr K+ transport system regulatory component TrkA/KtrA/KtrC, RCK domain [Inorganic ion ...
 376-517 2.62e-10

Trk/Ktr K+ transport system regulatory component TrkA/KtrA/KtrC, RCK domain [Inorganic ion transport and metabolism, Signal transduction mechanisms];


Pssm-ID: 440335 [Multi-domain]  Cd Length: 296  Bit Score: 61.62  E-value: 2.62e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1330122459 376 RRDKRIDPGRAQVLILGMGRIGTGAYDELRtRYGKVSLGVEVREEAAHNHRSQGRNVISGDATDPDFWERiLDTANVKLV 455
Cdd:COG0569    86 RMERGIKKLKMHVIIIGAGRVGRSLARELE-EEGHDVVVIDKDPERVERLAEEDVLVIVGDATDEEVLEE-AGIEDADAV 163

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1330122459 456 ILAMPHHQGNQTALEQLKSRNFKgQIAAIAEYPDQLETLKENGVDAAFNIYSEAGSGFARHV 517
Cdd:COG0569   164 IAATGDDEANILACLLAKELGVP-RIIARANDPEYADLLERLGADVVISPERLAARRIARLL 224
NhaP COG0025
NhaP-type Na+/H+ or K+/H+ antiporter [Inorganic ion transport and metabolism];
3-308 3.77e-04

NhaP-type Na+/H+ or K+/H+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 439796 [Multi-domain]  Cd Length: 506  Bit Score: 43.03  E-value: 3.77e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1330122459   3 LILISTAFIAGFIALKCHLPPLVGFLVAGFGLF-AFGFETN---DTIITLADLGVTLLLFTIGLKLDIKTLFS--KEIWA 76
Cdd:COG0025     8 LLLLLLGLLSQWLARRLKLPAPLLLLLAGILLGpGLGLELDpelGDLEPLLELFLPPLLFEAALNLDLRELRRngRPILR 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1330122459  77 GATIHNLLSTlfFAVALFGFKFLGISSLAAmsveqiVLLGFALSFSSTVfAVKTLQEKGEMNATYGTL---------AIG 147
Cdd:COG0025    88 LAVVGVLLTT--LAVALAAHWLLGLPLAAA------LLLGAILAPTDPV-AVSPILRRLGVPKRLRTIlegesllndATA 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1330122459 148 ILvmqdIFAVVFLTASTGKIPEWYAIALFALPLLRP---------LFYKVLDWVGHGEM---LVLSGIFFALVVgAGLFH 215
Cdd:COG0025   159 LV----LFVLALAAALGGGFSLGEALLDFLLAILGGilvglllgwLLGRLLRRLPDPLLeilLTLALPFLAYLL-AEALH 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1330122459 216 LVGVkpdLGALVLGMLLA---GHPKASELSKSLFNLKE----LFLVCFFLNIGLS------EQPTIQGFMLAILFLLMLP 282
Cdd:COG0025   234 GSGV---LAVVVAGLVLGnagRRSLSPETRLQLLEFWEtlefLLNSLLFVLLGAQlplillGALGLGGILLVLLALLVVR 310

                         330       340
                  ....*....|....*....|....*.
gi 1330122459 283 VKGVLYFLVLNRFKFRVRTSLLASLS 308
Cdd:COG0025   311 PLWVFLSLALRGSRLSWRERLFLSWG 336
PLN03159 PLN03159
cation/H(+) antiporter 15; Provisional
 44-278 2.99e-03

cation/H(+) antiporter 15; Provisional


Pssm-ID: 215608 [Multi-domain]  Cd Length: 832  Bit Score: 40.26  E-value: 2.99e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1330122459  44 TIITLADLGVTLLLFTIGLKLDIKTL--FSKEIWAGATIHNLLStlFFAVALFGFKFLGISSlaamSVEQ---IVLLGFA 118
Cdd:PLN03159  103 VLETMANLGLLYFLFLVGVEMDISVIrrTGKKALAIAIAGMALP--FCIGLAFSFIFHQVSR----NVHQgtfILFLGVA 176

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1330122459 119 LSFSSTVFAVKTLQEKGEMNATYGTLAIGILVMQDIFAVVFL--------TASTGKIPEWYAIA-----LFALPLLRPLF 185
Cdd:PLN03159  177 LSVTAFPVLARILAEIKLINTELGRIAMSAALVNDMCAWILLalaialaeNDSTSLASLWVLLSsvafvLFCFYVVRPGI 256

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1330122459 186 YKVLDWVGHGEM-------LVLSGIFFALVVGAGlfhlVGVKPDLGALVLGMLLAGHPKASELSKSLFN-LKELFLVCFF 257
Cdd:PLN03159  257 WWIIRRTPEGETfsefyicLILTGVMISGFITDA----IGTHSVFGAFVFGLVIPNGPLGVTLIEKLEDfVSGLLLPLFF 332

                         250       260
                  ....*....|....*....|....*..
gi 1330122459 258 ------LNIGLSEQPTIQGFMLAILFL 278
Cdd:PLN03159  333 aisglkTNVTKIQGPATWGLLVLVIIM 359
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH