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Concise Results
Standard Results
Full Results
MULTISPECIES: alpha-ketoglutarate dehydrogenase [unclassified Pseudomonas]
Protein Classification
pyruvate dehydrogenase E1 component ( domain architecture ID 11486350 )
E1 component of the acetyl-transferring homodimeric-type pyruvate dehydrogenase multienzyme complex
List of domain hits
Name
Accession
Description
Interval
E-value
PRK13012
PRK13012 2-oxoacid dehydrogenase subunit E1; Provisional
14-891
0e+00
2-oxoacid dehydrogenase subunit E1; Provisional
Pssm-ID: 237267 [Multi-domain]
Cd Length: 896
Bit Score: 1698.97
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331381824 14 D QE E L AEW RD AL ASL VA N AG AA RAR EI LD M L ADAGG A PH IA WKPRHG TPY I N S I A V E QQPP F PGDLA T EERLA SVV RWNA 93
Cdd:PRK13012 21 D PQ E T AEW LE AL DAV VA H AG PE RAR YL LD R L LERAA A RG IA LPGLLT TPY V N T I P V D QQPP Y PGDLA L EERLA AII RWNA 100
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331381824 94 LAMVVRAN Q AYGELGGHIASYASAADLFEVGFNHFFR A R S D SF GGDLV FY QPHSAPGIYARAFLEGRLSE AD L A H Y RQEI 173
Cdd:PRK13012 101 LAMVVRAN R AYGELGGHIASYASAADLFEVGFNHFFR G R D D AG GGDLV YF QPHSAPGIYARAFLEGRLSE EQ L D H F RQEI 180
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331381824 174 G AG kagar GLSSYPHPWLMPDFWQFPTGSMGIGPI SS I F QARFMRYLQHRGL Q D STD R H VWG V FGDGEMDEPES MS AL T L 253
Cdd:PRK13012 181 G GP ----- GLSSYPHPWLMPDFWQFPTGSMGIGPI NA I Y QARFMRYLQHRGL K D TSG R K VWG F FGDGEMDEPES IA AL S L 255
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331381824 254 AAREGLDNL TW V V NCNLQRLDGPVRGNGRII D ELEALF A GAGWNVIK LV WGSDWDAL L A K DT D G E L A R TLSQ TVDGQFQT 333
Cdd:PRK13012 256 AAREGLDNL VF V I NCNLQRLDGPVRGNGRII Q ELEALF R GAGWNVIK VL WGSDWDAL F A R DT T G A L V R RFAE TVDGQFQT 335
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331381824 334 F A A K DGAYNREHFFGQ SEA L SK LV EG LSDE Q IDRLKRGGHD MV K IH AAY H AA R R VA G K PTVILA Q TKKG F GMGEAG Q G K M 413
Cdd:PRK13012 336 F K A N DGAYNREHFFGQ DPE L AA LV AH LSDE D IDRLKRGGHD PR K VY AAY A AA V R HK G Q PTVILA K TKKG Y GMGEAG E G R M 415
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331381824 414 TTHQQKKLD R EAL I AFR N RF Q LPLSDEQ A E S L S FYKPAE G S L EMRYLH Q RRA T LGGY V P S R GQQ AP SVS VPP V S GYGA FA 493
Cdd:PRK13012 416 TTHQQKKLD V EAL K AFR D RF R LPLSDEQ L E Q L P FYKPAE D S P EMRYLH A RRA A LGGY L P R R RTA AP PLP VPP L S AFAQ FA 495
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331381824 494 TQ A E GKEMSTTMAFVRML T NLLKDKALGPRIVPIVADEARTFGMANLF K Q I GIYS SV GQ R YEPED I GS I L S YREA T DGQI 573
Cdd:PRK13012 496 LG A G GKEMSTTMAFVRML G NLLKDKALGPRIVPIVADEARTFGMANLF R Q V GIYS PL GQ L YEPED A GS L L Y YREA K DGQI 575
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331381824 574 LEEGI S EA S AISSW V AAATSYSVHGL R MLPFYIYYSMFGFQRVGDLIWAAADQRARGFLLGATAGRTTLGGEGLQHQDG S 653
Cdd:PRK13012 576 LEEGI T EA G AISSW I AAATSYSVHGL P MLPFYIYYSMFGFQRVGDLIWAAADQRARGFLLGATAGRTTLGGEGLQHQDG H 655
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331381824 654 SHL M A A T V PNCRAYDPAFA G E F AVI L D H GMR Q MLE HDV D E FYY V T L MNENY P QP S LPEG V E AA I I KGMYRL SGQPGG - K V 732
Cdd:PRK13012 656 SHL L A S T I PNCRAYDPAFA Y E L AVI V D D GMR R MLE EQE D V FYY L T V MNENY A QP A LPEG A E EG I L KGMYRL AAAAEA p R V 735
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331381824 733 R LLGSG TLV RE AQ AAA Q LLA E DW Q VDA E V F SVTSF S EL A RD ARDV ER W N R L H P QQP AR RSHLAE CL PKG - A PVVA VS DYV 811
Cdd:PRK13012 736 Q LLGSG AIL RE VL AAA R LLA D DW G VDA D V W SVTSF T EL R RD GLAA ER A N L L G P AEE AR VPYVTQ CL AGT r G PVVA AT DYV 815
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331381824 812 RAVP QMLGSY V DSA Y TV LGTDGFGRSDTRAALR D FFEVDRH H IVLAAL T AL VEQ G SLD R Q V CQQ AI K RYG VQT D RE P S W T 891
Cdd:PRK13012 816 RAVP EQIRAF V PAR Y VT LGTDGFGRSDTRAALR R FFEVDRH S IVLAAL K AL ADD G EVE R T V VAE AI E RYG IDD D KT P P W E 895
Name
Accession
Description
Interval
E-value
PRK13012
PRK13012 2-oxoacid dehydrogenase subunit E1; Provisional
14-891
0e+00
2-oxoacid dehydrogenase subunit E1; Provisional
Pssm-ID: 237267 [Multi-domain]
Cd Length: 896
Bit Score: 1698.97
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331381824 14 D QE E L AEW RD AL ASL VA N AG AA RAR EI LD M L ADAGG A PH IA WKPRHG TPY I N S I A V E QQPP F PGDLA T EERLA SVV RWNA 93
Cdd:PRK13012 21 D PQ E T AEW LE AL DAV VA H AG PE RAR YL LD R L LERAA A RG IA LPGLLT TPY V N T I P V D QQPP Y PGDLA L EERLA AII RWNA 100
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331381824 94 LAMVVRAN Q AYGELGGHIASYASAADLFEVGFNHFFR A R S D SF GGDLV FY QPHSAPGIYARAFLEGRLSE AD L A H Y RQEI 173
Cdd:PRK13012 101 LAMVVRAN R AYGELGGHIASYASAADLFEVGFNHFFR G R D D AG GGDLV YF QPHSAPGIYARAFLEGRLSE EQ L D H F RQEI 180
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331381824 174 G AG kagar GLSSYPHPWLMPDFWQFPTGSMGIGPI SS I F QARFMRYLQHRGL Q D STD R H VWG V FGDGEMDEPES MS AL T L 253
Cdd:PRK13012 181 G GP ----- GLSSYPHPWLMPDFWQFPTGSMGIGPI NA I Y QARFMRYLQHRGL K D TSG R K VWG F FGDGEMDEPES IA AL S L 255
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331381824 254 AAREGLDNL TW V V NCNLQRLDGPVRGNGRII D ELEALF A GAGWNVIK LV WGSDWDAL L A K DT D G E L A R TLSQ TVDGQFQT 333
Cdd:PRK13012 256 AAREGLDNL VF V I NCNLQRLDGPVRGNGRII Q ELEALF R GAGWNVIK VL WGSDWDAL F A R DT T G A L V R RFAE TVDGQFQT 335
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331381824 334 F A A K DGAYNREHFFGQ SEA L SK LV EG LSDE Q IDRLKRGGHD MV K IH AAY H AA R R VA G K PTVILA Q TKKG F GMGEAG Q G K M 413
Cdd:PRK13012 336 F K A N DGAYNREHFFGQ DPE L AA LV AH LSDE D IDRLKRGGHD PR K VY AAY A AA V R HK G Q PTVILA K TKKG Y GMGEAG E G R M 415
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331381824 414 TTHQQKKLD R EAL I AFR N RF Q LPLSDEQ A E S L S FYKPAE G S L EMRYLH Q RRA T LGGY V P S R GQQ AP SVS VPP V S GYGA FA 493
Cdd:PRK13012 416 TTHQQKKLD V EAL K AFR D RF R LPLSDEQ L E Q L P FYKPAE D S P EMRYLH A RRA A LGGY L P R R RTA AP PLP VPP L S AFAQ FA 495
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331381824 494 TQ A E GKEMSTTMAFVRML T NLLKDKALGPRIVPIVADEARTFGMANLF K Q I GIYS SV GQ R YEPED I GS I L S YREA T DGQI 573
Cdd:PRK13012 496 LG A G GKEMSTTMAFVRML G NLLKDKALGPRIVPIVADEARTFGMANLF R Q V GIYS PL GQ L YEPED A GS L L Y YREA K DGQI 575
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331381824 574 LEEGI S EA S AISSW V AAATSYSVHGL R MLPFYIYYSMFGFQRVGDLIWAAADQRARGFLLGATAGRTTLGGEGLQHQDG S 653
Cdd:PRK13012 576 LEEGI T EA G AISSW I AAATSYSVHGL P MLPFYIYYSMFGFQRVGDLIWAAADQRARGFLLGATAGRTTLGGEGLQHQDG H 655
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331381824 654 SHL M A A T V PNCRAYDPAFA G E F AVI L D H GMR Q MLE HDV D E FYY V T L MNENY P QP S LPEG V E AA I I KGMYRL SGQPGG - K V 732
Cdd:PRK13012 656 SHL L A S T I PNCRAYDPAFA Y E L AVI V D D GMR R MLE EQE D V FYY L T V MNENY A QP A LPEG A E EG I L KGMYRL AAAAEA p R V 735
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331381824 733 R LLGSG TLV RE AQ AAA Q LLA E DW Q VDA E V F SVTSF S EL A RD ARDV ER W N R L H P QQP AR RSHLAE CL PKG - A PVVA VS DYV 811
Cdd:PRK13012 736 Q LLGSG AIL RE VL AAA R LLA D DW G VDA D V W SVTSF T EL R RD GLAA ER A N L L G P AEE AR VPYVTQ CL AGT r G PVVA AT DYV 815
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331381824 812 RAVP QMLGSY V DSA Y TV LGTDGFGRSDTRAALR D FFEVDRH H IVLAAL T AL VEQ G SLD R Q V CQQ AI K RYG VQT D RE P S W T 891
Cdd:PRK13012 816 RAVP EQIRAF V PAR Y VT LGTDGFGRSDTRAALR R FFEVDRH S IVLAAL K AL ADD G EVE R T V VAE AI E RYG IDD D KT P P W E 895
AceE
COG2609 Pyruvate dehydrogenase complex, dehydrogenase (E1) component [Energy production and conversion] ...
1-892
0e+00
Pyruvate dehydrogenase complex, dehydrogenase (E1) component [Energy production and conversion]; Pyruvate dehydrogenase complex, dehydrogenase (E1) component is part of the Pathway/BioSystem: Pyruvate oxidation
Pssm-ID: 442021 [Multi-domain]
Cd Length: 891
Bit Score: 1647.88
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331381824 1 M NGFASAVSQTAM D QE E LA EW RDA L ASLVANA G AA RAR EI L DM L ADAGGAPHIAWKPRHG TPYIN S I A VEQ Q PP F PGD LA 80
Cdd:COG2609 1 M SMDGLPSQLPDI D PQ E TQ EW LES L DAVIEEE G PE RAR YL L ER L LERARRSGVGLPFSAT TPYIN T I P VEQ E PP Y PGD EE 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331381824 81 T E E R LA S VV RWNA L AMVVRAN QAY G E LGGHI A S Y ASAA D L F EVGFNHFFR ARSDSF GGDLV FY Q P H SA PGIYARAFLEGR 160
Cdd:COG2609 81 L E R R IR S II RWNA M AMVVRAN RKG G G LGGHI S S F ASAA T L Y EVGFNHFFR GPDHPG GGDLV YF Q G H AS PGIYARAFLEGR 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331381824 161 L S E AD L AHY RQE IGAG kagar GLSSYPHPWLMPDFWQFPT G SMG I GPI SS I F QARFM R YL QH RGL Q D ST DR H VW GVF GDG 240
Cdd:COG2609 161 L T E EQ L DNF RQE VDGK ----- GLSSYPHPWLMPDFWQFPT V SMG L GPI NA I Y QARFM K YL HN RGL K D TS DR K VW AFL GDG 235
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331381824 241 EMDEPES MS A LT LAARE G LDNL TW V V NCNLQRLDGPVRGNG R II D ELE AL F A GAGWNVIK LV WGS D WD A LLAKDTDG E L A 320
Cdd:COG2609 236 EMDEPES LG A IS LAARE K LDNL IF V I NCNLQRLDGPVRGNG K II Q ELE GV F R GAGWNVIK VI WGS E WD P LLAKDTDG A L V 315
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331381824 321 RTLSQ TVDG QF QT FA AKDGAY N REHFFG QSEA L SK LV EGL SDE Q I D RL K RGGHD MV K IH AAY H AA RRVA G K PTVILA Q T K 400
Cdd:COG2609 316 KRMNE TVDG DY QT YK AKDGAY V REHFFG KYPE L KA LV ADM SDE D I W RL N RGGHD PR K VY AAY K AA VEHK G Q PTVILA K T I 395
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331381824 401 KG F GMGEAG Q G KMT THQQKKLD REA L I AFR N RF QL P L SDEQ A E S L SF YKPAE G S L EM R YLH Q RR AT LGGY V P S R GQQ A PS 480
Cdd:COG2609 396 KG Y GMGEAG E G RNI THQQKKLD LDD L K AFR D RF NI P I SDEQ L E E L PY YKPAE D S P EM K YLH E RR KA LGGY L P Q R RTK A EP 475
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331381824 481 VS VP PV S GYG A FATQAEGK E M STTMAFVR M L TN LLKDK AL G P RIVPIV A DEARTFGM AN LF K QIGIYS S VGQ R Y E P E D IG 560
Cdd:COG2609 476 LE VP EL S AFA A LLKGSGKR E I STTMAFVR I L ND LLKDK EI G K RIVPIV P DEARTFGM EG LF R QIGIYS P VGQ L Y T P V D AD 555
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331381824 561 SI L S Y R E AT DGQIL E EGI S EA S A I SSW V AA A TSYS V HG LR M L PFYIYYSMFGFQRVGDL I WAA A DQRARGFL L GATAGRT 640
Cdd:COG2609 556 QL L Y Y K E SK DGQIL Q EGI N EA G A M SSW I AA G TSYS T HG VP M I PFYIYYSMFGFQRVGDL A WAA G DQRARGFL I GATAGRT 635
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331381824 641 TL G GEGLQHQDG S SHL M A A T V PNC RA YDPAFA G E F AVI LDH G M R Q M LEHDVDE FYY V T L MNENY P QP SL PEGVE AA I I KG 720
Cdd:COG2609 636 TL N GEGLQHQDG H SHL L A S T I PNC VS YDPAFA Y E L AVI VQD G L R R M YGEQENV FYY I T V MNENY A QP AM PEGVE EG I L KG 715
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331381824 721 MY R L S --- G QPGGK V R LLGSGT LV RE AQ AAA Q LLAEDW Q V D A E V F SVTSF S EL A RD AR DVERWN R LHP QQPA R RSHLAE C 797
Cdd:COG2609 716 MY L L K ege G KGKPR V Q LLGSGT IL RE VL AAA E LLAEDW G V A A D V W SVTSF N EL R RD GL DVERWN L LHP EEEP R VPYVTQ C 795
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331381824 798 L PKG - A PVVA VS DY V RAVP QMLGSY V DSA YTVLGTDGFGRSDTR A ALR D FFEVDR HH IV L AAL T AL VEQ G SL D RQ V CQQ A 876
Cdd:COG2609 796 L AGA e G PVVA AT DY M RAVP DQIRPW V PGR YTVLGTDGFGRSDTR E ALR R FFEVDR YS IV V AAL K AL ADE G KI D AS V VAE A 875
890
....*....|....*.
gi 1331381824 877 IK R YG VQT D REPSW T S 892
Cdd:COG2609 876 IK K YG IDP D KPNPL T A 891
AKGDH_not_PDH
TIGR03186 alpha-ketoglutarate dehydrogenase; Several bacterial species have a paralog to homodimeric ...
14-892
0e+00
alpha-ketoglutarate dehydrogenase; Several bacterial species have a paralog to homodimeric form of the pyruvate dehydrogenase E1 component (see model TIGR00759), often encoded next to L-methionine gamma-lyase gene (mdeA). The member from a strain of Pseudomonas putida was shown to act on alpha-ketobutyrate, which is produced by MdeA.This model serves as an exception model to TIGR00759, as other proteins hitting TIGR00759 should be identified as the pyruvate dehydrogenase E1 component.
Pssm-ID: 132230 [Multi-domain]
Cd Length: 889
Bit Score: 1393.07
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331381824 14 D QE E L AEW R DAL ASL VA N AGA A RA REI L DM LA DAGGAPHI A WKPRHG TPY I N S IAV E Q Q PP F PGDL AT EERLA SVV RWNA 93
Cdd:TIGR03186 7 D PQ E T AEW L DAL DGV VA H AGA E RA QYL L AQ LA AHAARLGL A PPAAGA TPY V N T IAV D Q E PP Y PGDL QL EERLA AIL RWNA 86
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331381824 94 LAMVVRAN Q AYGELGGHIASYASAADLFEVGFNHFFRA RS D SF GGDLV FY QPHSAPG I YARAFLEG R LS E A D LAHYRQEI 173
Cdd:TIGR03186 87 LAMVVRAN R AYGELGGHIASYASAADLFEVGFNHFFRA AG D AS GGDLV YF QPHSAPG V YARAFLEG F LS D A Q LAHYRQEI 166
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331381824 174 GA gkaga R GL S SYPHPWLMPDFWQFPTGSMGIGPI SS I F QARFMRYLQ H RGL QDSTD R H VWG V FGDGEMDEPES MS AL T L 253
Cdd:TIGR03186 167 AG ----- P GL C SYPHPWLMPDFWQFPTGSMGIGPI NA I Y QARFMRYLQ N RGL ARTEG R K VWG F FGDGEMDEPES IG AL S L 241
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331381824 254 AARE G LDNL TW V V NCNLQRLDGPVRGNGRIIDELE AL FAGAGWNVIK LV WGSDWDAL L A K D TD G E LAR TLSQ TVDGQFQT 333
Cdd:TIGR03186 242 AARE R LDNL VF V I NCNLQRLDGPVRGNGRIIDELE SQ FAGAGWNVIK VL WGSDWDAL F A R D AT G A LAR AFAH TVDGQFQT 321
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331381824 334 F A A K DGAYNR EH FFGQ SE AL SK LV EG LSDE Q IDRL K RGGHD MV K IH AAY HA A R R VA G K PTVILA Q T K KGFGMG EA GQG K M 413
Cdd:TIGR03186 322 F S A N DGAYNR AR FFGQ DP AL AA LV AH LSDE D IDRL R RGGHD AR K LY AAY DR A V R HE G R PTVILA K T M KGFGMG AI GQG R M 401
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331381824 414 TTHQQKKLD R EAL I AFR N RF Q LPLSD EQA E S L S FYKP A E G S L EMRYLH Q RRA T LGGY V P S R GQQ A P - SVS VP PVSGY G A F 492
Cdd:TIGR03186 402 TTHQQKKLD V EAL L AFR D RF R LPLSD ADV E Q L K FYKP D E D S A EMRYLH A RRA A LGGY L P R R RTA A T h ALA VP ALPSW G R F 481
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331381824 493 A TQ AEGKEMSTTMA F VRML TN LLKD KA LGPRIVPIVADEARTFGMANLF K Q I GIYS SV GQRYEPED I GS I L S YRE A TDGQ 572
Cdd:TIGR03186 482 A LD AEGKEMSTTMA I VRML GA LLKD AE LGPRIVPIVADEARTFGMANLF R Q V GIYS PL GQRYEPED L GS M L Y YRE D TDGQ 561
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331381824 573 ILEEGISEA S AISSW V AAATSYSVH G L R MLPFYIYYSMFGFQR V GDLIWAAADQRARGFL L GAT A G R TTLGGEGLQHQDG 652
Cdd:TIGR03186 562 ILEEGISEA G AISSW I AAATSYSVH D L P MLPFYIYYSMFGFQR I GDLIWAAADQRARGFL I GAT S G K TTLGGEGLQHQDG 641
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331381824 653 S SHL M A A TVPNCRA Y DPAFA G E F AVI L D H GMR Q MLE HDV DEFYY V T LM NENY P QPSLPE G ---- V EAA I I KGMY R L -- SG 726
Cdd:TIGR03186 642 T SHL A A S TVPNCRA W DPAFA Y E V AVI V D E GMR E MLE RQR DEFYY L T VT NENY A QPSLPE D rlda V RRG I L KGMY P L dp AA 721
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331381824 727 QPGGK V R LLGSG TLVR E A QAAA Q LL AE DW QV DA E V F SVTSF S ELARD A R DV ER WN RL HPQQPARRS H L A EC L - PKGA PV V 805
Cdd:TIGR03186 722 LAAAR V Q LLGSG AILG E V QAAA R LL RD DW GI DA A V W SVTSF T ELARD G R AA ER AQ RL GDAERPPSP H V A QA L g ATQG PV I 801
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331381824 806 A VS DYVRAVP QMLGS YV DSA Y TV LGTDGFGRSDTRAALR D FFEVDR HH IV L AAL T AL VEQ G SLD R Q V CQ QAI K RYG VQ - T 884
Cdd:TIGR03186 802 A AT DYVRAVP ELIRA YV PRR Y VT LGTDGFGRSDTRAALR A FFEVDR AS IV I AAL Q AL ADD G LVA R D V VR QAI A RYG KA a T 881
....*...
gi 1331381824 885 D R E P S W TS 892
Cdd:TIGR03186 882 S R A P P W ER 889
TPP_E1_EcPDC_like
cd02017 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; ...
82-469
0e+00
Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative decarboxylation of pyruvate and the subsequent acetylation of coenzyme A to acetyl-CoA. The E1 component of PDC catalyzes the first step of the multistep process, using TPP and a divalent cation as cofactors. E. coli PDC is a homodimeric enzyme.
Pssm-ID: 238975 [Multi-domain]
Cd Length: 386
Bit Score: 626.64
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331381824 82 E E R LA S VV RWNA L AMV V RAN QAYGEL GGHIA SY ASAA D L F EVGFNHFFRAR SDSF GGDLV FY Q P H SA PGIYARAFLEGRL 161
Cdd:cd02017 4 E R R IR S LI RWNA M AMV H RAN KKDLGI GGHIA TF ASAA T L Y EVGFNHFFRAR GEGG GGDLV YF Q G H AS PGIYARAFLEGRL 83
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331381824 162 S E AD L AHY RQE I G A G kagar GLSSYPHPWLMPDFW Q FPT G SMG I GPI SS I F QARF M RYL QH RGL Q D ST D RH VW GVF GDGE 241
Cdd:cd02017 84 T E EQ L DNF RQE V G G G ----- GLSSYPHPWLMPDFW E FPT V SMG L GPI QA I Y QARF N RYL ED RGL K D TS D QK VW AFL GDGE 158
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331381824 242 MDEPES MS A LT LAARE G LDNL TW VVNCNLQRLDGPVRGNG R II D ELE AL F A GAGWNVIK LV WGS D WD A LLAKD TD G E L AR 321
Cdd:cd02017 159 MDEPES LG A IG LAARE K LDNL IF VVNCNLQRLDGPVRGNG K II Q ELE GI F R GAGWNVIK VI WGS K WD E LLAKD GG G A L RQ 238
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331381824 322 TLSQ TVDG QF QT FA AKDGAY N REHFFG QSEA L SK LV EG LSDE QIDR L K RGGHD MV K IH AAY HA A RRVA GKPTVILA Q T K K 401
Cdd:cd02017 239 RMEE TVDG DY QT LK AKDGAY V REHFFG KYPE L KA LV TD LSDE DLWA L N RGGHD PR K VY AAY KK A VEHK GKPTVILA K T I K 318
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1331381824 402 G F G M G E AG Q G KMTT HQ Q KK LDREA L I A F R N RF QL P L SDEQ A E SLSF YKP A EGS L E MR YLH Q RR AT LGG 469
Cdd:cd02017 319 G Y G L G A AG E G RNHA HQ V KK MTEDE L K A L R D RF GI P V SDEQ L E EGPY YKP P EGS E E IK YLH E RR HA LGG 386
PDH_E1_M
pfam17831 Pyruvate dehydrogenase E1 component middle domain; This entry represents one of the thiamin ...
492-707
2.70e-100
Pyruvate dehydrogenase E1 component middle domain; This entry represents one of the thiamin diphosphate-binding domains found in pyruvate dehydrogenase E1 component.
Pssm-ID: 465525 [Multi-domain]
Cd Length: 229
Bit Score: 312.05
E-value: 2.70e-100
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331381824 492 FA T Q --- AE G K E M STTMAFVR M L TN L L KDK AL G PRI VPI VA DEARTFGM ANL F K Q I GIY S S V GQ R YEP E D I G S I LS YRE A 568
Cdd:pfam17831 11 FA S Q tgg SK G R E I STTMAFVR I L NG L V KDK KI G KQV VPI IP DEARTFGM EGM F R Q L GIY T S E GQ K YEP V D K G Q I MF YRE D 90
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331381824 569 TD GQILEEGISEA S A I S S W V AAATSYS V H GLRM LPFY I YYSMFGFQR V GDL I WAA A D QR ARGFL L G A TAGRTTL G GEGLQ 648
Cdd:pfam17831 91 KQ GQILEEGISEA G A M S A W I AAATSYS N H NTTL LPFY V YYSMFGFQR I GDL A WAA G D MQ ARGFL V G G TAGRTTL N GEGLQ 170
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 1331381824 649 HQDG S SH LM A A T V PNCR A YDP AF A G E F AVI LDH G MRQ M LEHDVDE FYY V T L MNENY PQ P 707
Cdd:pfam17831 171 HQDG H SH IQ A S T I PNCR S YDP TY A H E V AVI VQD G LKR M FADKENC FYY L T V MNENY EH P 229
Transket_pyr
smart00861 Transketolase, pyrimidine binding domain; Transketolase (TK) catalyzes the reversible transfer ...
563-685
1.05e-05
Transketolase, pyrimidine binding domain; Transketolase (TK) catalyzes the reversible transfer of a two-carbon ketol unit from xylulose 5-phosphate to an aldose receptor, such as ribose 5-phosphate, to form sedoheptulose 7-phosphate and glyceraldehyde 3- phosphate. This enzyme, together with transaldolase, provides a link between the glycolytic and pentose-phosphate pathways. TK requires thiamine pyrophosphate as a cofactor. In most sources where TK has been purified, it is a homodimer of approximately 70 Kd subunits. TK sequences from a variety of eukaryotic and prokaryotic sources show that the enzyme has been evolutionarily conserved. In the peroxisomes of methylotrophic yeast Hansenula polymorpha, there is a highly related enzyme, dihydroxy-acetone synthase (DHAS) (also known as formaldehyde transketolase), which exhibits a very unusual specificity by including formaldehyde amongst its substrates.
Pssm-ID: 214865 [Multi-domain]
Cd Length: 136
Bit Score: 45.94
E-value: 1.05e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331381824 563 LSY R E A T d G QI L E E ----- GI S E ASA issw V AA A TSYSV HGLR ml P FYIYYSM F g F Q R VG D - LIW A A A DQRA rg FLLGAT 636
Cdd:smart00861 3 IAT R K A F - G EA L A E laidt GI A E QAM ---- V GF A AGLAL HGLR -- P VVEIFFT F - F D R AK D q IRS A G A SGNV -- PVVFRH 72
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 1331381824 637 A G RTTL G GE G LQ H QDGSSHLMAATV P NCRAYD P AFAG E FAVI L DHGM R Q 685
Cdd:smart00861 73 D G GGGV G ED G PT H HSIEDEALLRAI P GLKVVA P SDPA E AKGL L RAAI R D 121
Name
Accession
Description
Interval
E-value
PRK13012
PRK13012 2-oxoacid dehydrogenase subunit E1; Provisional
14-891
0e+00
2-oxoacid dehydrogenase subunit E1; Provisional
Pssm-ID: 237267 [Multi-domain]
Cd Length: 896
Bit Score: 1698.97
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331381824 14 D QE E L AEW RD AL ASL VA N AG AA RAR EI LD M L ADAGG A PH IA WKPRHG TPY I N S I A V E QQPP F PGDLA T EERLA SVV RWNA 93
Cdd:PRK13012 21 D PQ E T AEW LE AL DAV VA H AG PE RAR YL LD R L LERAA A RG IA LPGLLT TPY V N T I P V D QQPP Y PGDLA L EERLA AII RWNA 100
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331381824 94 LAMVVRAN Q AYGELGGHIASYASAADLFEVGFNHFFR A R S D SF GGDLV FY QPHSAPGIYARAFLEGRLSE AD L A H Y RQEI 173
Cdd:PRK13012 101 LAMVVRAN R AYGELGGHIASYASAADLFEVGFNHFFR G R D D AG GGDLV YF QPHSAPGIYARAFLEGRLSE EQ L D H F RQEI 180
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331381824 174 G AG kagar GLSSYPHPWLMPDFWQFPTGSMGIGPI SS I F QARFMRYLQHRGL Q D STD R H VWG V FGDGEMDEPES MS AL T L 253
Cdd:PRK13012 181 G GP ----- GLSSYPHPWLMPDFWQFPTGSMGIGPI NA I Y QARFMRYLQHRGL K D TSG R K VWG F FGDGEMDEPES IA AL S L 255
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331381824 254 AAREGLDNL TW V V NCNLQRLDGPVRGNGRII D ELEALF A GAGWNVIK LV WGSDWDAL L A K DT D G E L A R TLSQ TVDGQFQT 333
Cdd:PRK13012 256 AAREGLDNL VF V I NCNLQRLDGPVRGNGRII Q ELEALF R GAGWNVIK VL WGSDWDAL F A R DT T G A L V R RFAE TVDGQFQT 335
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331381824 334 F A A K DGAYNREHFFGQ SEA L SK LV EG LSDE Q IDRLKRGGHD MV K IH AAY H AA R R VA G K PTVILA Q TKKG F GMGEAG Q G K M 413
Cdd:PRK13012 336 F K A N DGAYNREHFFGQ DPE L AA LV AH LSDE D IDRLKRGGHD PR K VY AAY A AA V R HK G Q PTVILA K TKKG Y GMGEAG E G R M 415
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331381824 414 TTHQQKKLD R EAL I AFR N RF Q LPLSDEQ A E S L S FYKPAE G S L EMRYLH Q RRA T LGGY V P S R GQQ AP SVS VPP V S GYGA FA 493
Cdd:PRK13012 416 TTHQQKKLD V EAL K AFR D RF R LPLSDEQ L E Q L P FYKPAE D S P EMRYLH A RRA A LGGY L P R R RTA AP PLP VPP L S AFAQ FA 495
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331381824 494 TQ A E GKEMSTTMAFVRML T NLLKDKALGPRIVPIVADEARTFGMANLF K Q I GIYS SV GQ R YEPED I GS I L S YREA T DGQI 573
Cdd:PRK13012 496 LG A G GKEMSTTMAFVRML G NLLKDKALGPRIVPIVADEARTFGMANLF R Q V GIYS PL GQ L YEPED A GS L L Y YREA K DGQI 575
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331381824 574 LEEGI S EA S AISSW V AAATSYSVHGL R MLPFYIYYSMFGFQRVGDLIWAAADQRARGFLLGATAGRTTLGGEGLQHQDG S 653
Cdd:PRK13012 576 LEEGI T EA G AISSW I AAATSYSVHGL P MLPFYIYYSMFGFQRVGDLIWAAADQRARGFLLGATAGRTTLGGEGLQHQDG H 655
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331381824 654 SHL M A A T V PNCRAYDPAFA G E F AVI L D H GMR Q MLE HDV D E FYY V T L MNENY P QP S LPEG V E AA I I KGMYRL SGQPGG - K V 732
Cdd:PRK13012 656 SHL L A S T I PNCRAYDPAFA Y E L AVI V D D GMR R MLE EQE D V FYY L T V MNENY A QP A LPEG A E EG I L KGMYRL AAAAEA p R V 735
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331381824 733 R LLGSG TLV RE AQ AAA Q LLA E DW Q VDA E V F SVTSF S EL A RD ARDV ER W N R L H P QQP AR RSHLAE CL PKG - A PVVA VS DYV 811
Cdd:PRK13012 736 Q LLGSG AIL RE VL AAA R LLA D DW G VDA D V W SVTSF T EL R RD GLAA ER A N L L G P AEE AR VPYVTQ CL AGT r G PVVA AT DYV 815
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331381824 812 RAVP QMLGSY V DSA Y TV LGTDGFGRSDTRAALR D FFEVDRH H IVLAAL T AL VEQ G SLD R Q V CQQ AI K RYG VQT D RE P S W T 891
Cdd:PRK13012 816 RAVP EQIRAF V PAR Y VT LGTDGFGRSDTRAALR R FFEVDRH S IVLAAL K AL ADD G EVE R T V VAE AI E RYG IDD D KT P P W E 895
AceE
COG2609 Pyruvate dehydrogenase complex, dehydrogenase (E1) component [Energy production and conversion] ...
1-892
0e+00
Pyruvate dehydrogenase complex, dehydrogenase (E1) component [Energy production and conversion]; Pyruvate dehydrogenase complex, dehydrogenase (E1) component is part of the Pathway/BioSystem: Pyruvate oxidation
Pssm-ID: 442021 [Multi-domain]
Cd Length: 891
Bit Score: 1647.88
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331381824 1 M NGFASAVSQTAM D QE E LA EW RDA L ASLVANA G AA RAR EI L DM L ADAGGAPHIAWKPRHG TPYIN S I A VEQ Q PP F PGD LA 80
Cdd:COG2609 1 M SMDGLPSQLPDI D PQ E TQ EW LES L DAVIEEE G PE RAR YL L ER L LERARRSGVGLPFSAT TPYIN T I P VEQ E PP Y PGD EE 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331381824 81 T E E R LA S VV RWNA L AMVVRAN QAY G E LGGHI A S Y ASAA D L F EVGFNHFFR ARSDSF GGDLV FY Q P H SA PGIYARAFLEGR 160
Cdd:COG2609 81 L E R R IR S II RWNA M AMVVRAN RKG G G LGGHI S S F ASAA T L Y EVGFNHFFR GPDHPG GGDLV YF Q G H AS PGIYARAFLEGR 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331381824 161 L S E AD L AHY RQE IGAG kagar GLSSYPHPWLMPDFWQFPT G SMG I GPI SS I F QARFM R YL QH RGL Q D ST DR H VW GVF GDG 240
Cdd:COG2609 161 L T E EQ L DNF RQE VDGK ----- GLSSYPHPWLMPDFWQFPT V SMG L GPI NA I Y QARFM K YL HN RGL K D TS DR K VW AFL GDG 235
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331381824 241 EMDEPES MS A LT LAARE G LDNL TW V V NCNLQRLDGPVRGNG R II D ELE AL F A GAGWNVIK LV WGS D WD A LLAKDTDG E L A 320
Cdd:COG2609 236 EMDEPES LG A IS LAARE K LDNL IF V I NCNLQRLDGPVRGNG K II Q ELE GV F R GAGWNVIK VI WGS E WD P LLAKDTDG A L V 315
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331381824 321 RTLSQ TVDG QF QT FA AKDGAY N REHFFG QSEA L SK LV EGL SDE Q I D RL K RGGHD MV K IH AAY H AA RRVA G K PTVILA Q T K 400
Cdd:COG2609 316 KRMNE TVDG DY QT YK AKDGAY V REHFFG KYPE L KA LV ADM SDE D I W RL N RGGHD PR K VY AAY K AA VEHK G Q PTVILA K T I 395
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331381824 401 KG F GMGEAG Q G KMT THQQKKLD REA L I AFR N RF QL P L SDEQ A E S L SF YKPAE G S L EM R YLH Q RR AT LGGY V P S R GQQ A PS 480
Cdd:COG2609 396 KG Y GMGEAG E G RNI THQQKKLD LDD L K AFR D RF NI P I SDEQ L E E L PY YKPAE D S P EM K YLH E RR KA LGGY L P Q R RTK A EP 475
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331381824 481 VS VP PV S GYG A FATQAEGK E M STTMAFVR M L TN LLKDK AL G P RIVPIV A DEARTFGM AN LF K QIGIYS S VGQ R Y E P E D IG 560
Cdd:COG2609 476 LE VP EL S AFA A LLKGSGKR E I STTMAFVR I L ND LLKDK EI G K RIVPIV P DEARTFGM EG LF R QIGIYS P VGQ L Y T P V D AD 555
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331381824 561 SI L S Y R E AT DGQIL E EGI S EA S A I SSW V AA A TSYS V HG LR M L PFYIYYSMFGFQRVGDL I WAA A DQRARGFL L GATAGRT 640
Cdd:COG2609 556 QL L Y Y K E SK DGQIL Q EGI N EA G A M SSW I AA G TSYS T HG VP M I PFYIYYSMFGFQRVGDL A WAA G DQRARGFL I GATAGRT 635
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331381824 641 TL G GEGLQHQDG S SHL M A A T V PNC RA YDPAFA G E F AVI LDH G M R Q M LEHDVDE FYY V T L MNENY P QP SL PEGVE AA I I KG 720
Cdd:COG2609 636 TL N GEGLQHQDG H SHL L A S T I PNC VS YDPAFA Y E L AVI VQD G L R R M YGEQENV FYY I T V MNENY A QP AM PEGVE EG I L KG 715
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331381824 721 MY R L S --- G QPGGK V R LLGSGT LV RE AQ AAA Q LLAEDW Q V D A E V F SVTSF S EL A RD AR DVERWN R LHP QQPA R RSHLAE C 797
Cdd:COG2609 716 MY L L K ege G KGKPR V Q LLGSGT IL RE VL AAA E LLAEDW G V A A D V W SVTSF N EL R RD GL DVERWN L LHP EEEP R VPYVTQ C 795
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331381824 798 L PKG - A PVVA VS DY V RAVP QMLGSY V DSA YTVLGTDGFGRSDTR A ALR D FFEVDR HH IV L AAL T AL VEQ G SL D RQ V CQQ A 876
Cdd:COG2609 796 L AGA e G PVVA AT DY M RAVP DQIRPW V PGR YTVLGTDGFGRSDTR E ALR R FFEVDR YS IV V AAL K AL ADE G KI D AS V VAE A 875
890
....*....|....*.
gi 1331381824 877 IK R YG VQT D REPSW T S 892
Cdd:COG2609 876 IK K YG IDP D KPNPL T A 891
aceE
PRK09405 pyruvate dehydrogenase subunit E1; Reviewed
14-892
0e+00
pyruvate dehydrogenase subunit E1; Reviewed
Pssm-ID: 236500 [Multi-domain]
Cd Length: 891
Bit Score: 1556.66
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331381824 14 D QE E LA EW RD AL A S LVANA G AA RA REI L DM L ADAGGAPHIAWKPRHG TPYIN S I A VE QQ P PF PGDL AT E E R LA S VV RWNA 93
Cdd:PRK09405 13 D PI E TQ EW LE AL D S VIREE G PE RA HYL L EQ L LERAREKGVSLPASAT TPYIN T I P VE EE P EY PGDL EL E R R IR S YI RWNA 92
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331381824 94 L AMV V RAN QAYGE LGGHI A S Y AS A A D L F EVGFNHFFRA RSDSF GGDLVF Y Q P H SA PGIYARAFLEGRL S E AD L AHY RQE I 173
Cdd:PRK09405 93 A AMV L RAN KKDLG LGGHI S S F AS S A T L Y EVGFNHFFRA PNEPH GGDLVF F Q G H AS PGIYARAFLEGRL T E EQ L DNF RQE V 172
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331381824 174 G a GK agar GLSSYPHPWLMPDFWQFPT G SMG I GPI SS I F QARF MR YL QH RGL Q D ST D RH VW GVF GDGEMDEPES MS A LT L 253
Cdd:PRK09405 173 D - GK ---- GLSSYPHPWLMPDFWQFPT V SMG L GPI MA I Y QARF LK YL EN RGL K D TS D QK VW AFL GDGEMDEPES LG A IS L 247
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331381824 254 AARE G LDNL TW V V NCNLQRLDGPVRGNG R II D ELE AL F A GAGWNVIK LV WGS D WD A LLAKDT D G E L ARTLSQ TVDG QF QT 333
Cdd:PRK09405 248 AARE K LDNL IF V I NCNLQRLDGPVRGNG K II Q ELE GI F R GAGWNVIK VI WGS R WD P LLAKDT S G K L VQLMNE TVDG DY QT 327
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331381824 334 FA AKDGAY N REHFFG QSEALSK LV EGL SD EQ I DR L K RGGHD MV K IH AAY H AA RRVA G K PTVILA Q T K KG F GMGEAG Q GK M 413
Cdd:PRK09405 328 YK AKDGAY V REHFFG KYPETKA LV ADM SD DD I WA L N RGGHD PR K VY AAY K AA VEHK G Q PTVILA K T I KG Y GMGEAG E GK N 407
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331381824 414 TT HQ Q KKLD REA L IA FR N RF QL P L SDEQ A E S L SF YKP A E G S L E MR YLH Q RR AT LGGY V P S R GQQAPSVS VP PV S GYG A FA 493
Cdd:PRK09405 408 IA HQ V KKLD LDD L KH FR D RF NI P I SDEQ L E K L PY YKP G E D S P E IK YLH E RR KA LGGY L P A R RPKFEPLE VP AL S AFE A LL 487
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331381824 494 TQAEGK E M STTMAFVR M L TN LLKDK AL G P RIVPI VA DEARTFGM AN LF K QIGIY SSV GQ R Y E P E D IGSILS Y R E AT DGQI 573
Cdd:PRK09405 488 KGSGER E I STTMAFVR I L NI LLKDK EI G K RIVPI IP DEARTFGM EG LF R QIGIY NPH GQ L Y T P V D RDQLMY Y K E SK DGQI 567
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331381824 574 L E EGI S EA S A IS SW V AAATSYS V HG LR M L PFYIYYSMFGFQR V GDL I WAA A DQRARGFLLG A TAGRTTL G GEGLQH Q DG S 653
Cdd:PRK09405 568 L Q EGI N EA G A MA SW I AAATSYS T HG EP M I PFYIYYSMFGFQR I GDL A WAA G DQRARGFLLG G TAGRTTL N GEGLQH E DG H 647
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331381824 654 SH LM A A T V PNC RA YDPAFA G E F AVI LDH G M R Q M LEHDVDE FYY V T L MNENY P QP SL PEG V E AA I I KGMY R L S ---- GQPG 729
Cdd:PRK09405 648 SH IL A S T I PNC VS YDPAFA Y E V AVI VQD G L R R M YGEQENV FYY I T V MNENY H QP AM PEG A E EG I L KGMY K L E taeg KKGK 727
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331381824 730 G KV R LLGSGT LV RE AQA AA QL LAED WQ V D A E V F SVTSF S ELARD AR DVERWN R LHP QQPA R RSHLAEC L p KGA -- PVVA V 807
Cdd:PRK09405 728 P KV Q LLGSGT IL RE VLE AA EI LAED YG V A A D V W SVTSF N ELARD GQ DVERWN M LHP TEEP R VPYVTQV L - KGA eg PVVA A 806
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331381824 808 S DY VRAVPQMLGSY V DSA Y T VLGTDGFGRSDTR A ALR D FFEVD RHHI V L AAL T AL VEQ G SL D RQ V CQQ AIK R YG VQT D RE 887
Cdd:PRK09405 807 T DY MKLFAEQIRAF V PGD Y V VLGTDGFGRSDTR E ALR R FFEVD AEYV V V AAL K AL ADE G EI D AS V VAE AIK K YG IDP D KA 886
....*
gi 1331381824 888 PSW T S 892
Cdd:PRK09405 887 NPR T A 891
AKGDH_not_PDH
TIGR03186 alpha-ketoglutarate dehydrogenase; Several bacterial species have a paralog to homodimeric ...
14-892
0e+00
alpha-ketoglutarate dehydrogenase; Several bacterial species have a paralog to homodimeric form of the pyruvate dehydrogenase E1 component (see model TIGR00759), often encoded next to L-methionine gamma-lyase gene (mdeA). The member from a strain of Pseudomonas putida was shown to act on alpha-ketobutyrate, which is produced by MdeA.This model serves as an exception model to TIGR00759, as other proteins hitting TIGR00759 should be identified as the pyruvate dehydrogenase E1 component.
Pssm-ID: 132230 [Multi-domain]
Cd Length: 889
Bit Score: 1393.07
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331381824 14 D QE E L AEW R DAL ASL VA N AGA A RA REI L DM LA DAGGAPHI A WKPRHG TPY I N S IAV E Q Q PP F PGDL AT EERLA SVV RWNA 93
Cdd:TIGR03186 7 D PQ E T AEW L DAL DGV VA H AGA E RA QYL L AQ LA AHAARLGL A PPAAGA TPY V N T IAV D Q E PP Y PGDL QL EERLA AIL RWNA 86
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331381824 94 LAMVVRAN Q AYGELGGHIASYASAADLFEVGFNHFFRA RS D SF GGDLV FY QPHSAPG I YARAFLEG R LS E A D LAHYRQEI 173
Cdd:TIGR03186 87 LAMVVRAN R AYGELGGHIASYASAADLFEVGFNHFFRA AG D AS GGDLV YF QPHSAPG V YARAFLEG F LS D A Q LAHYRQEI 166
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331381824 174 GA gkaga R GL S SYPHPWLMPDFWQFPTGSMGIGPI SS I F QARFMRYLQ H RGL QDSTD R H VWG V FGDGEMDEPES MS AL T L 253
Cdd:TIGR03186 167 AG ----- P GL C SYPHPWLMPDFWQFPTGSMGIGPI NA I Y QARFMRYLQ N RGL ARTEG R K VWG F FGDGEMDEPES IG AL S L 241
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331381824 254 AARE G LDNL TW V V NCNLQRLDGPVRGNGRIIDELE AL FAGAGWNVIK LV WGSDWDAL L A K D TD G E LAR TLSQ TVDGQFQT 333
Cdd:TIGR03186 242 AARE R LDNL VF V I NCNLQRLDGPVRGNGRIIDELE SQ FAGAGWNVIK VL WGSDWDAL F A R D AT G A LAR AFAH TVDGQFQT 321
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331381824 334 F A A K DGAYNR EH FFGQ SE AL SK LV EG LSDE Q IDRL K RGGHD MV K IH AAY HA A R R VA G K PTVILA Q T K KGFGMG EA GQG K M 413
Cdd:TIGR03186 322 F S A N DGAYNR AR FFGQ DP AL AA LV AH LSDE D IDRL R RGGHD AR K LY AAY DR A V R HE G R PTVILA K T M KGFGMG AI GQG R M 401
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331381824 414 TTHQQKKLD R EAL I AFR N RF Q LPLSD EQA E S L S FYKP A E G S L EMRYLH Q RRA T LGGY V P S R GQQ A P - SVS VP PVSGY G A F 492
Cdd:TIGR03186 402 TTHQQKKLD V EAL L AFR D RF R LPLSD ADV E Q L K FYKP D E D S A EMRYLH A RRA A LGGY L P R R RTA A T h ALA VP ALPSW G R F 481
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331381824 493 A TQ AEGKEMSTTMA F VRML TN LLKD KA LGPRIVPIVADEARTFGMANLF K Q I GIYS SV GQRYEPED I GS I L S YRE A TDGQ 572
Cdd:TIGR03186 482 A LD AEGKEMSTTMA I VRML GA LLKD AE LGPRIVPIVADEARTFGMANLF R Q V GIYS PL GQRYEPED L GS M L Y YRE D TDGQ 561
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331381824 573 ILEEGISEA S AISSW V AAATSYSVH G L R MLPFYIYYSMFGFQR V GDLIWAAADQRARGFL L GAT A G R TTLGGEGLQHQDG 652
Cdd:TIGR03186 562 ILEEGISEA G AISSW I AAATSYSVH D L P MLPFYIYYSMFGFQR I GDLIWAAADQRARGFL I GAT S G K TTLGGEGLQHQDG 641
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331381824 653 S SHL M A A TVPNCRA Y DPAFA G E F AVI L D H GMR Q MLE HDV DEFYY V T LM NENY P QPSLPE G ---- V EAA I I KGMY R L -- SG 726
Cdd:TIGR03186 642 T SHL A A S TVPNCRA W DPAFA Y E V AVI V D E GMR E MLE RQR DEFYY L T VT NENY A QPSLPE D rlda V RRG I L KGMY P L dp AA 721
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331381824 727 QPGGK V R LLGSG TLVR E A QAAA Q LL AE DW QV DA E V F SVTSF S ELARD A R DV ER WN RL HPQQPARRS H L A EC L - PKGA PV V 805
Cdd:TIGR03186 722 LAAAR V Q LLGSG AILG E V QAAA R LL RD DW GI DA A V W SVTSF T ELARD G R AA ER AQ RL GDAERPPSP H V A QA L g ATQG PV I 801
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331381824 806 A VS DYVRAVP QMLGS YV DSA Y TV LGTDGFGRSDTRAALR D FFEVDR HH IV L AAL T AL VEQ G SLD R Q V CQ QAI K RYG VQ - T 884
Cdd:TIGR03186 802 A AT DYVRAVP ELIRA YV PRR Y VT LGTDGFGRSDTRAALR A FFEVDR AS IV I AAL Q AL ADD G LVA R D V VR QAI A RYG KA a T 881
....*...
gi 1331381824 885 D R E P S W TS 892
Cdd:TIGR03186 882 S R A P P W ER 889
aceE
TIGR00759 pyruvate dehydrogenase E1 component, homodimeric type; Most members of this family are ...
14-890
0e+00
pyruvate dehydrogenase E1 component, homodimeric type; Most members of this family are pyruvate dehydrogenase complex, E1 component. Note: this family was classified as subfamily rather than equivalog because it includes a counterexample from Pseudomonas putida, MdeB, that is active as an E1 component of an alpha-ketoglutarate dehydrogenase complex rather than a pyruvate dehydrogase complex. The second pyruvate dehydrogenase complex E1 protein from Alcaligenes eutrophus, PdhE, complements an aceE mutant of E. coli but is not part of a pyruvate dehydrogenase complex operon, is more similar to the Pseudomonas putida MdeB than to E. coli AceE, and may have also have a different primary specificity.
Pssm-ID: 273255 [Multi-domain]
Cd Length: 885
Bit Score: 1339.41
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331381824 14 D QE E LA EW RDA L A S LV A NA G A ARAR EI L DM L ADAGGAPHIAWKPRHG T P YIN S I A VE Q QP PF PGDL AT E E R LA S VV RWNA 93
Cdd:TIGR00759 7 D PI E TQ EW LES L D S VL A EE G P ARAR YL L EQ L LEYAREHGVPIPAGTT T D YIN T I P VE E QP AY PGDL EL E R R IR S II RWNA 86
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331381824 94 L AMV V RAN QAYGE LGGHI AS YASAA D L F EVGFNHFFR AR S DSF GGDLVF Y Q P H S APGIYARAFLEGRL S E AD L AHY RQE I 173
Cdd:TIGR00759 87 I AMV L RAN KKDLG LGGHI ST YASAA T L Y EVGFNHFFR GH S EGG GGDLVF F Q G H A APGIYARAFLEGRL T E EQ L DNF RQE V 166
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331381824 174 GAG kagar GLSSYPHPWLMPDFWQFPT G SMG I GPI SS I F QARFM R YL QH RGL Q D ST D RH VW GVF GDGEMDEPES MS A L T L 253
Cdd:TIGR00759 167 QGD ----- GLSSYPHPWLMPDFWQFPT V SMG L GPI NA I Y QARFM K YL EN RGL K D TG D QK VW AFL GDGEMDEPES KG A I T F 241
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331381824 254 AARE G LDNLT W V V NCNLQRLDGPVRGNG R II D ELE A LF A GAGWNVIK LV WGS D WDALLA K DT D G E L ARTLSQ TVDG QF QT 333
Cdd:TIGR00759 242 AARE K LDNLT F V I NCNLQRLDGPVRGNG K II Q ELE S LF R GAGWNVIK VL WGS E WDALLA R DT S G V L VKLMNE TVDG DY QT 321
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331381824 334 FA AKDGAY N REHFF GQSEA L SK LV EGL SD EQ I DR L K RGGHD MV K IH AAY H AA RRVA G K PTVILA Q T K KG F GMG E A GQGKM 413
Cdd:TIGR00759 322 YK AKDGAY V REHFF NRTPE L KA LV ADM SD AD I WA L N RGGHD PR K VY AAY A AA QEHK G Q PTVILA K T I KG Y GMG D A AESRN 401
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331381824 414 T T HQ Q KKL DRE AL IA FR N RF Q LPLSD E Q A E S L SF Y K P A EGS L E M RYL HQ RR AT LGGY V P S R GQQ A PSVS VP PVSGY GA FA 493
Cdd:TIGR00759 402 T A HQ V KKL EVD AL KN FR D RF E LPLSD A Q V E E L PY Y H P G EGS P E V RYL LA RR QA LGGY L P A R RTF A EHLT VP ALEFF GA LL 481
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331381824 494 TQAEGK E M STTMAFVR M L TN LLKDK AL G P RIVPIV A DEARTFGM AN LF K QIGIYS SV GQ R Y E P E D IG S I L S Y R E AT DGQI 573
Cdd:TIGR00759 482 KGSGER E V STTMAFVR I L NK LLKDK EI G K RIVPIV P DEARTFGM EG LF R QIGIYS PH GQ T Y T P V D AD S L L A Y K E SK DGQI 561
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331381824 574 L E EGI S EA S A IS SW V AAATSY SV HG LR M L PFYIYYSMFGFQR V GDL I WAAADQRARGFLLGATAGRTTL G GEGLQH Q DG S 653
Cdd:TIGR00759 562 L Q EGI N EA G A MA SW I AAATSY AT HG EP M I PFYIYYSMFGFQR I GDL C WAAADQRARGFLLGATAGRTTL N GEGLQH E DG H 641
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331381824 654 S H L M AAT V PNC R AYDPAFA G E F AVI LDH G M R Q M LEHDV D E FYYVT L MNENY P QP SL PEG V E AA I I KG M YR LSGQPG ---- 729
Cdd:TIGR00759 642 S L L Q AAT I PNC I AYDPAFA Y E V AVI MED G L R R M YGEQE D V FYYVT V MNENY V QP PM PEG A E EG I L KG L YR FETSTE ekak 721
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331381824 730 G K V R LLGSG TLV R EAQA AAQLLA E DW Q V DAE V F SVTSF S ELARD AR DVERWN R LHP QQPA R R S HL A EC L PKG - APV V A VS 808
Cdd:TIGR00759 722 G H V Q LLGSG AIM R AVIE AAQLLA A DW G V ASD V W SVTSF T ELARD GH DVERWN L LHP TETP R V S YV A QV L NEA d APV I A ST 801
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331381824 809 DYVRA VPQMLGS YV DSA Y TV LGTDGFGRSDTR AA LR D FFEVD RHHI VLAAL T AL VEQ G SL D RQ V CQQ AI KR YG VQT D REP 888
Cdd:TIGR00759 802 DYVRA FAEQIRP YV PRK Y VT LGTDGFGRSDTR EN LR H FFEVD AKSV VLAAL Y AL ADD G EI D GD V VAD AI AK YG IDP D KAN 881
..
gi 1331381824 889 SW 890
Cdd:TIGR00759 882 PV 883
TPP_E1_EcPDC_like
cd02017 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; ...
82-469
0e+00
Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative decarboxylation of pyruvate and the subsequent acetylation of coenzyme A to acetyl-CoA. The E1 component of PDC catalyzes the first step of the multistep process, using TPP and a divalent cation as cofactors. E. coli PDC is a homodimeric enzyme.
Pssm-ID: 238975 [Multi-domain]
Cd Length: 386
Bit Score: 626.64
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331381824 82 E E R LA S VV RWNA L AMV V RAN QAYGEL GGHIA SY ASAA D L F EVGFNHFFRAR SDSF GGDLV FY Q P H SA PGIYARAFLEGRL 161
Cdd:cd02017 4 E R R IR S LI RWNA M AMV H RAN KKDLGI GGHIA TF ASAA T L Y EVGFNHFFRAR GEGG GGDLV YF Q G H AS PGIYARAFLEGRL 83
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331381824 162 S E AD L AHY RQE I G A G kagar GLSSYPHPWLMPDFW Q FPT G SMG I GPI SS I F QARF M RYL QH RGL Q D ST D RH VW GVF GDGE 241
Cdd:cd02017 84 T E EQ L DNF RQE V G G G ----- GLSSYPHPWLMPDFW E FPT V SMG L GPI QA I Y QARF N RYL ED RGL K D TS D QK VW AFL GDGE 158
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331381824 242 MDEPES MS A LT LAARE G LDNL TW VVNCNLQRLDGPVRGNG R II D ELE AL F A GAGWNVIK LV WGS D WD A LLAKD TD G E L AR 321
Cdd:cd02017 159 MDEPES LG A IG LAARE K LDNL IF VVNCNLQRLDGPVRGNG K II Q ELE GI F R GAGWNVIK VI WGS K WD E LLAKD GG G A L RQ 238
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331381824 322 TLSQ TVDG QF QT FA AKDGAY N REHFFG QSEA L SK LV EG LSDE QIDR L K RGGHD MV K IH AAY HA A RRVA GKPTVILA Q T K K 401
Cdd:cd02017 239 RMEE TVDG DY QT LK AKDGAY V REHFFG KYPE L KA LV TD LSDE DLWA L N RGGHD PR K VY AAY KK A VEHK GKPTVILA K T I K 318
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1331381824 402 G F G M G E AG Q G KMTT HQ Q KK LDREA L I A F R N RF QL P L SDEQ A E SLSF YKP A EGS L E MR YLH Q RR AT LGG 469
Cdd:cd02017 319 G Y G L G A AG E G RNHA HQ V KK MTEDE L K A L R D RF GI P V SDEQ L E EGPY YKP P EGS E E IK YLH E RR HA LGG 386
PDH_E1_M
pfam17831 Pyruvate dehydrogenase E1 component middle domain; This entry represents one of the thiamin ...
492-707
2.70e-100
Pyruvate dehydrogenase E1 component middle domain; This entry represents one of the thiamin diphosphate-binding domains found in pyruvate dehydrogenase E1 component.
Pssm-ID: 465525 [Multi-domain]
Cd Length: 229
Bit Score: 312.05
E-value: 2.70e-100
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331381824 492 FA T Q --- AE G K E M STTMAFVR M L TN L L KDK AL G PRI VPI VA DEARTFGM ANL F K Q I GIY S S V GQ R YEP E D I G S I LS YRE A 568
Cdd:pfam17831 11 FA S Q tgg SK G R E I STTMAFVR I L NG L V KDK KI G KQV VPI IP DEARTFGM EGM F R Q L GIY T S E GQ K YEP V D K G Q I MF YRE D 90
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331381824 569 TD GQILEEGISEA S A I S S W V AAATSYS V H GLRM LPFY I YYSMFGFQR V GDL I WAA A D QR ARGFL L G A TAGRTTL G GEGLQ 648
Cdd:pfam17831 91 KQ GQILEEGISEA G A M S A W I AAATSYS N H NTTL LPFY V YYSMFGFQR I GDL A WAA G D MQ ARGFL V G G TAGRTTL N GEGLQ 170
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 1331381824 649 HQDG S SH LM A A T V PNCR A YDP AF A G E F AVI LDH G MRQ M LEHDVDE FYY V T L MNENY PQ P 707
Cdd:pfam17831 171 HQDG H SH IQ A S T I PNCR S YDP TY A H E V AVI VQD G LKR M FADKENC FYY L T V MNENY EH P 229
TPP_TK
cd02012 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK ...
89-404
1.91e-22
Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the pentose phosphate pathway and provides precursors for nucleotide, aromatic amino acid and vitamin biosynthesis. In addition, the enzyme plays a central role in the Calvin cycle in plants. Typically, TKs are homodimers. They require TPP and divalent cations, such as magnesium ions, for activity.
Pssm-ID: 238970 [Multi-domain]
Cd Length: 255
Bit Score: 97.57
E-value: 1.91e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331381824 89 V R WNALA MV VR A N qaygel G GH IASYA SAAD LFE V GFNHFFR --- A RSDSFGG D - L V FYQP H SA P GI YA RAF L E G R L S E A 164
Cdd:cd02012 3 I R RLSID MV QK A G ------ S GH PGGSL SAAD ILA V LYFKVLK ydp A DPKWPNR D r F V LSKG H AS P AL YA VLA L A G Y L P E E 76
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331381824 165 DL AHY RQ e I G agkagargl S SY P - HP - WLMPDFWQFP TGS M G I G PISSIFQ A RFMRY L Q hrglqds T D RH V WGVF GDGE M 242
Cdd:cd02012 77 DL KTF RQ - L G --------- S RL P g HP e YGLTPGVEVT TGS L G Q G LSVAVGM A LAEKL L G ------- F D YR V YVLL GDGE L 139
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331381824 243 D E PESMS A LTL A AREG LDNL TWV V NC N LQRL DGP VRG --- NGRIIDEL EA L faga GWNVI klvwgsdwdallakdtdgel 319
Cdd:cd02012 140 Q E GSVWE A ASF A GHYK LDNL IAI V DS N RIQI DGP TDD ilf TEDLAKKF EA F ---- GWNVI -------------------- 195
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331381824 320 artlsq T VD gqfqtfaakdgaynrehffgqsealsklveglsdeqidrlkrg GHD MVK I H AA YHA A RRVA GKPT V I L A Q T 399
Cdd:cd02012 196 ------ E VD ------------------------------------------- GHD VEE I L AA LEE A KKSK GKPT L I I A K T 226
....*
gi 1331381824 400 K KG F G 404
Cdd:cd02012 227 I KG K G 231
PRK05899
PRK05899 transketolase; Reviewed
78-404
2.72e-15
transketolase; Reviewed
Pssm-ID: 235639 [Multi-domain]
Cd Length: 586
Bit Score: 80.18
E-value: 2.72e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331381824 78 D LATEER LA SVV R WNALAM V VR AN Q aygelg GH IASYAS AAD LFE V GFNH F F R --- ARSDSFGG D - L V FYQP H SAPGI Y A 153
Cdd:PRK05899 4 D MELLQL LA NAI R VLSIDA V QK AN S ------ GH PGMPMG AAD IAY V LWTR F L R hdp KNPKWPNR D r F V LSAG H GSMLL Y S 77
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331381824 154 RAF L E G - R LS EA DL AHY RQ eigagk A G argl S SY P - HP wlmp DFWQF P ----- TG SM G I G p ISS ---- IFQARFMRY L QH 222
Cdd:PRK05899 78 LLH L A G y D LS ID DL KNF RQ ------ L G ---- S KT P g HP ---- EYGHT P gvett TG PL G Q G - LAN avgm ALAEKYLAA L FN 142
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331381824 223 R GLQ D ST D RHVWGVF GDG EMD E PE S MS A LT LA AREG L D NL TWVVNC N - LQ r L DGP VR G N gr IIDELEAL F AGA GW N VI K l 301
Cdd:PRK05899 143 R PGL D IV D HYTYVLC GDG DLM E GI S HE A CS LA GHLK L G NL IVIYDD N r IS - I DGP TE G W -- FTEDVKKR F EAY GW H VI E - 218
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331381824 302 vwgsdwdallakdtdgelartlsqt VD gqfqtfaakdgaynrehffgqsealsklveglsdeqidrlkrg GHD MVK I H AA 381
Cdd:PRK05899 219 ------------------------- VD ------------------------------------------- GHD VEA I D AA 230
330 340
....*....|....*....|...
gi 1331381824 382 YHA A RRV a G KPT V I L A Q T KK G F G 404
Cdd:PRK05899 231 IEE A KAS - T KPT L I I A K T II G K G 252
Transketolase_N
pfam00456 Transketolase, thiamine diphosphate binding domain; This family includes transketolase enzymes ...
81-404
1.28e-06
Transketolase, thiamine diphosphate binding domain; This family includes transketolase enzymes EC:2.2.1.1. and also partially matches to 2-oxoisovalerate dehydrogenase beta subunit EC:1.2.4.4. Both these enzymes utilize thiamine pyrophosphate as a cofactor, suggesting there may be common aspects in their mechanism of catalysis.
Pssm-ID: 395366 [Multi-domain]
Cd Length: 334
Bit Score: 51.23
E-value: 1.28e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331381824 81 TEE R LASVV R WN A LAM V VR AN qaygel G GH IASYASA A DLF EV G F NH F FR --- ARSDSFGG D - L V FYQP H SAPGI Y ARAF 156
Cdd:pfam00456 1 IDK R AVNAI R AL A MDA V EK AN ------ S GH PGAPMGM A PIA EV L F KR F LK hnp NDPKWINR D r F V LSNG H GSMLL Y SLLH 74
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331381824 157 L E G - R LS EA DL AHY RQ e I G AGKA G arglssyp HP wlmp D F WQFP ----- TG SM G I G PISSIFQ A RFM R Y L Q --- H R GLQ D 227
Cdd:pfam00456 75 L T G y D LS ME DL KSF RQ - L G SKTP G -------- HP ---- E F GHTA gvevt TG PL G Q G IANAVGM A IAE R N L A aty N R PGF D 141
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331381824 228 ST D RHVWGVF GDG EMD E PE S MS A LT LA ARE GL D NL TWVVNC N LQRL DG PVRGN gr IIDELE A L F AGA GW N VI KLV wgsdw 307
Cdd:pfam00456 142 IV D HYTYVFL GDG CLM E GV S SE A SS LA GHL GL G NL IVFYDD N QISI DG ETKIS -- FTEDTA A R F EAY GW H VI EVE ----- 214
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331381824 308 dallakdtdgelartlsqtvdgqfqtfaakdgaynrehffgqsealsklveglsdeqidrlkr G GHD MVK I H AA YHA A RR 387
Cdd:pfam00456 215 --------------------------------------------------------------- D GHD VEA I A AA IEE A KA 231
330
....*....|....*..
gi 1331381824 388 VAG KPT V I LAQ T KK G F G 404
Cdd:pfam00456 232 EKD KPT L I KCR T VI G Y G 248
Transket_pyr
smart00861 Transketolase, pyrimidine binding domain; Transketolase (TK) catalyzes the reversible transfer ...
563-685
1.05e-05
Transketolase, pyrimidine binding domain; Transketolase (TK) catalyzes the reversible transfer of a two-carbon ketol unit from xylulose 5-phosphate to an aldose receptor, such as ribose 5-phosphate, to form sedoheptulose 7-phosphate and glyceraldehyde 3- phosphate. This enzyme, together with transaldolase, provides a link between the glycolytic and pentose-phosphate pathways. TK requires thiamine pyrophosphate as a cofactor. In most sources where TK has been purified, it is a homodimer of approximately 70 Kd subunits. TK sequences from a variety of eukaryotic and prokaryotic sources show that the enzyme has been evolutionarily conserved. In the peroxisomes of methylotrophic yeast Hansenula polymorpha, there is a highly related enzyme, dihydroxy-acetone synthase (DHAS) (also known as formaldehyde transketolase), which exhibits a very unusual specificity by including formaldehyde amongst its substrates.
Pssm-ID: 214865 [Multi-domain]
Cd Length: 136
Bit Score: 45.94
E-value: 1.05e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331381824 563 LSY R E A T d G QI L E E ----- GI S E ASA issw V AA A TSYSV HGLR ml P FYIYYSM F g F Q R VG D - LIW A A A DQRA rg FLLGAT 636
Cdd:smart00861 3 IAT R K A F - G EA L A E laidt GI A E QAM ---- V GF A AGLAL HGLR -- P VVEIFFT F - F D R AK D q IRS A G A SGNV -- PVVFRH 72
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 1331381824 637 A G RTTL G GE G LQ H QDGSSHLMAATV P NCRAYD P AFAG E FAVI L DHGM R Q 685
Cdd:smart00861 73 D G GGGV G ED G PT H HSIEDEALLRAI P GLKVVA P SDPA E AKGL L RAAI R D 121
TktA
COG0021 Transketolase [Carbohydrate transport and metabolism]; Transketolase is part of the Pathway ...
230-404
4.19e-03
Transketolase [Carbohydrate transport and metabolism]; Transketolase is part of the Pathway/BioSystem: Pentose phosphate pathway
Pssm-ID: 439792 [Multi-domain]
Cd Length: 661
Bit Score: 40.76
E-value: 4.19e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331381824 230 D RHVWGVF GDG EMD E PE S MS A LT LA AREG L DN L TWVVNC N LQRL DG PV rg NGRIIDELEAL F AGA GW N VI KLVW G sdwda 309
Cdd:COG0021 146 D HYTYVIA GDG DLM E GI S HE A AS LA GHLK L GK L IVLYDD N GISI DG DT -- DLAFSEDVAKR F EAY GW H VI RVED G ----- 218
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1331381824 310 llakdtdgelartlsqtvdgqfqtfaakdgaynrehffgqsealsklveglsdeqidrlkrgg HD MVK I H AA YH AA RRVA 389
Cdd:COG0021 219 --------------------------------------------------------------- HD LEA I D AA IE AA KAET 235
170
....*....|....*
gi 1331381824 390 G KPT V I LAQ T KK G F G 404
Cdd:COG0021 236 D KPT L I ICK T II G Y G 250
Blast search parameters
Data Source:
Precalculated data, version = cdd.v.3.21
Preset Options: Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
