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Conserved domains on  [gi|1333914986|ref|WP_103017138|]
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TMEM165/GDT1 family protein [Salinibacter ruber]

Protein Classification

TMEM165/GDT1 family protein( domain architecture ID 11450136)

TMEM165/GDT1 family protein similar to mammalian Golgi-localized transmembrane protein 165 (TMEM165) and its yeast ortholog, Gcr1 dependent translation factor 1 (Gdt1p), which are involved in calcium and pH homeostasis and might function as Ca(2+)/H(+) antiporters

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Gdt1 COG2119
Putative Ca2+/H+ antiporter, TMEM165/GDT1 family [General function prediction only];
4-213 8.82e-46

Putative Ca2+/H+ antiporter, TMEM165/GDT1 family [General function prediction only];


:

Pssm-ID: 441722 [Multi-domain]  Cd Length: 192  Bit Score: 150.74  E-value: 8.82e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333914986   4 WIEIMLIAAGAQLAVLPGEKVQFIIAGLSTRFSPYLIVAAAGSAFAGWTILEVTFGAVLRDALPQLYLDLLTAGLFLLFA 83
Cdd:COG2119     1 MMEAFLTSFGLVALAELGDKTQLLALALATRYRPWPVLAGILAATLLNHALAVALGSWLASLLPPDYLRWVAALLFLAFG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333914986  84 VLMYRsapesgttsPASEADDEGwigagtvevlGVELPSSLATFLGIFSMMAFGEVGDKTQLVTISLAVQYEAASAIWLG 163
Cdd:COG2119    81 LWLLR---------PDKLDEEEA----------KAAEKSRFGPFLTTFVAFFLAEMGDKTQLATIALAARYGAPLAVWLG 141
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 1333914986 164 EMLAILPVSLANALFFHHFAHRVNFRKAHFVGTGIFLFFALDMLLSVTTG 213
Cdd:COG2119   142 TTLGMMLASALAVLLGRKLAKRIPLRLIHRIAAALFLLFGLVTLLEALGG 191
 
Name Accession Description Interval E-value
Gdt1 COG2119
Putative Ca2+/H+ antiporter, TMEM165/GDT1 family [General function prediction only];
4-213 8.82e-46

Putative Ca2+/H+ antiporter, TMEM165/GDT1 family [General function prediction only];


Pssm-ID: 441722 [Multi-domain]  Cd Length: 192  Bit Score: 150.74  E-value: 8.82e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333914986   4 WIEIMLIAAGAQLAVLPGEKVQFIIAGLSTRFSPYLIVAAAGSAFAGWTILEVTFGAVLRDALPQLYLDLLTAGLFLLFA 83
Cdd:COG2119     1 MMEAFLTSFGLVALAELGDKTQLLALALATRYRPWPVLAGILAATLLNHALAVALGSWLASLLPPDYLRWVAALLFLAFG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333914986  84 VLMYRsapesgttsPASEADDEGwigagtvevlGVELPSSLATFLGIFSMMAFGEVGDKTQLVTISLAVQYEAASAIWLG 163
Cdd:COG2119    81 LWLLR---------PDKLDEEEA----------KAAEKSRFGPFLTTFVAFFLAEMGDKTQLATIALAARYGAPLAVWLG 141
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 1333914986 164 EMLAILPVSLANALFFHHFAHRVNFRKAHFVGTGIFLFFALDMLLSVTTG 213
Cdd:COG2119   142 TTLGMMLASALAVLLGRKLAKRIPLRLIHRIAAALFLLFGLVTLLEALGG 191
UPF0016 pfam01169
Uncharacterized protein family UPF0016; This family contains integral membrane proteins of ...
128-203 1.71e-11

Uncharacterized protein family UPF0016; This family contains integral membrane proteins of unknown function. Most members of the family contain two copies of a region that contains an EXGD motif. Each of these regions contains three predicted transmembrane regions. It has been suggested that these proteins are calcium transporters.


Pssm-ID: 460096  Cd Length: 75  Bit Score: 58.20  E-value: 1.71e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1333914986 128 LGIFSMMAFGEVGDKTQLVTISLAVQYeAASAIWLGEMLAILPVSLANALFFHHFAHRVNFRKAHFVGTGIFLFFA 203
Cdd:pfam01169   1 LTSFLLIFLAELGDKTQLATIALAARY-RRLAVFLGATLALALATVLAVLLGSWLARRLPERLVHLVAAALFLVFG 75
 
Name Accession Description Interval E-value
Gdt1 COG2119
Putative Ca2+/H+ antiporter, TMEM165/GDT1 family [General function prediction only];
4-213 8.82e-46

Putative Ca2+/H+ antiporter, TMEM165/GDT1 family [General function prediction only];


Pssm-ID: 441722 [Multi-domain]  Cd Length: 192  Bit Score: 150.74  E-value: 8.82e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333914986   4 WIEIMLIAAGAQLAVLPGEKVQFIIAGLSTRFSPYLIVAAAGSAFAGWTILEVTFGAVLRDALPQLYLDLLTAGLFLLFA 83
Cdd:COG2119     1 MMEAFLTSFGLVALAELGDKTQLLALALATRYRPWPVLAGILAATLLNHALAVALGSWLASLLPPDYLRWVAALLFLAFG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333914986  84 VLMYRsapesgttsPASEADDEGwigagtvevlGVELPSSLATFLGIFSMMAFGEVGDKTQLVTISLAVQYEAASAIWLG 163
Cdd:COG2119    81 LWLLR---------PDKLDEEEA----------KAAEKSRFGPFLTTFVAFFLAEMGDKTQLATIALAARYGAPLAVWLG 141
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 1333914986 164 EMLAILPVSLANALFFHHFAHRVNFRKAHFVGTGIFLFFALDMLLSVTTG 213
Cdd:COG2119   142 TTLGMMLASALAVLLGRKLAKRIPLRLIHRIAAALFLLFGLVTLLEALGG 191
UPF0016 pfam01169
Uncharacterized protein family UPF0016; This family contains integral membrane proteins of ...
128-203 1.71e-11

Uncharacterized protein family UPF0016; This family contains integral membrane proteins of unknown function. Most members of the family contain two copies of a region that contains an EXGD motif. Each of these regions contains three predicted transmembrane regions. It has been suggested that these proteins are calcium transporters.


Pssm-ID: 460096  Cd Length: 75  Bit Score: 58.20  E-value: 1.71e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1333914986 128 LGIFSMMAFGEVGDKTQLVTISLAVQYeAASAIWLGEMLAILPVSLANALFFHHFAHRVNFRKAHFVGTGIFLFFA 203
Cdd:pfam01169   1 LTSFLLIFLAELGDKTQLATIALAARY-RRLAVFLGATLALALATVLAVLLGSWLARRLPERLVHLVAAALFLVFG 75
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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