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Conserved domains on  [gi|1341972516|ref|WP_103967950|]
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transglycosylase SLT domain-containing protein [Billgrantia desiderata]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
mltD super family cl32574
membrane-bound lytic murein transglycosylase D; Provisional
 31-385 2.77e-90

membrane-bound lytic murein transglycosylase D; Provisional


The actual alignment was detected with superfamily member PRK10783:

Pssm-ID: 182727 [Multi-domain]  Cd Length: 456  Bit Score: 279.31  E-value: 2.77e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1341972516  31 LASPHPGATPAFPTHHFW-DDLNLEAMPGDAWERLRENLAwQERRHDARVQHWIEHYRANPGNVVEIIERARPWMAWITE 109
Cdd:PRK10783   32 LSSAGQGEAGKYTSQARWmDDGTSIAPDQDLWAFIGDELK-MGIPENSRIREQKQKYLRNKSYLHDVTLRAEPYMYWIVG 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1341972516 110 QVERRGLPGEVSLIPFIESSYDPHARSHRGAAGLWQFMPGTADALGLRRQGGYDGRLDVIAATNAALDYIElQAEQWYEG 189
Cdd:PRK10783  111 QIKKRNMPMELVLLPIVESAFDPHATSGANAAGIWQIIPSTGRNYGLKQTRWYDARRDVVASTTAALDMMQ-RLNKMFDG 189

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1341972516 190 DIELSLAAYNAGAGTVNRARHAALARGEAGEYWQLQLPNETMQYLPKLNAIAAIIDDPDAYGVALPEIDDAPAFAKVPVN 269
Cdd:PRK10783  190 DWLLTVAAYNSGEGRVMKAIKANKAKGKPTDFWSLSLPRETKIYVPKMLALSDILKNSKRYGVRLPTTDESRALARVDLG 269

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1341972516 270 RPIELSQLARVTGVDASELSALNPGLTNGSANPSTVEVVLVP---VEQEQVVLA--ELSAPAPQA-----PAGDSQYLVQ 339
Cdd:PRK10783  270 QQIELAQAAEMAGMSLTKLKTFNAGYKRSTTAPSGPHYIMVPkkhADQLRESLAsgEIAAVQSTLvadntPLNSRSYKVR 349

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*.
gi 1341972516 340 RGDSLSAIAARHSISVAELRQHNGLRGDTIQVGQTLEIPRRSLAAR 385
Cdd:PRK10783  350 SGDTLSGIASRLNVSTKDLQQWNNLRGSKLKVGQTLTIGAGSSAQR 395
 
Name Accession Description Interval E-value
mltD PRK10783
membrane-bound lytic murein transglycosylase D; Provisional
 31-385 2.77e-90

membrane-bound lytic murein transglycosylase D; Provisional


Pssm-ID: 182727 [Multi-domain]  Cd Length: 456  Bit Score: 279.31  E-value: 2.77e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1341972516  31 LASPHPGATPAFPTHHFW-DDLNLEAMPGDAWERLRENLAwQERRHDARVQHWIEHYRANPGNVVEIIERARPWMAWITE 109
Cdd:PRK10783   32 LSSAGQGEAGKYTSQARWmDDGTSIAPDQDLWAFIGDELK-MGIPENSRIREQKQKYLRNKSYLHDVTLRAEPYMYWIVG 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1341972516 110 QVERRGLPGEVSLIPFIESSYDPHARSHRGAAGLWQFMPGTADALGLRRQGGYDGRLDVIAATNAALDYIElQAEQWYEG 189
Cdd:PRK10783  111 QIKKRNMPMELVLLPIVESAFDPHATSGANAAGIWQIIPSTGRNYGLKQTRWYDARRDVVASTTAALDMMQ-RLNKMFDG 189

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1341972516 190 DIELSLAAYNAGAGTVNRARHAALARGEAGEYWQLQLPNETMQYLPKLNAIAAIIDDPDAYGVALPEIDDAPAFAKVPVN 269
Cdd:PRK10783  190 DWLLTVAAYNSGEGRVMKAIKANKAKGKPTDFWSLSLPRETKIYVPKMLALSDILKNSKRYGVRLPTTDESRALARVDLG 269

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1341972516 270 RPIELSQLARVTGVDASELSALNPGLTNGSANPSTVEVVLVP---VEQEQVVLA--ELSAPAPQA-----PAGDSQYLVQ 339
Cdd:PRK10783  270 QQIELAQAAEMAGMSLTKLKTFNAGYKRSTTAPSGPHYIMVPkkhADQLRESLAsgEIAAVQSTLvadntPLNSRSYKVR 349

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*.
gi 1341972516 340 RGDSLSAIAARHSISVAELRQHNGLRGDTIQVGQTLEIPRRSLAAR 385
Cdd:PRK10783  350 SGDTLSGIASRLNVSTKDLQQWNNLRGSKLKVGQTLTIGAGSSAQR 395
MltD-like cd16894
Membrane-bound lytic murein transglycosylase D and similar proteins; Lytic transglycosylases ...
 111-241 4.87e-44

Membrane-bound lytic murein transglycosylase D and similar proteins; Lytic transglycosylases (LT) catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc). Membrane-bound lytic murein transglycosylase D protein (MltD) family members may have one or more small LysM domains, which may contribute to peptidoglycan binding. Unlike the similar "goose-type" lysozymes, LTs also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue. Proteins similar to this family include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as the eukaryotic "goose-type" lysozymes (goose egg-white lysozyme; GEWL).


Pssm-ID: 381615 [Multi-domain]  Cd Length: 129  Bit Score: 148.82  E-value: 4.87e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1341972516 111 VERRGLPGEVSLIPFIESSYDPHARSHRGAAGLWQFMPGTADALGLRRQGGYDGRLDVIAATNAALDYI-ELQAEQwyeG 189
Cdd:cd16894     1 LLKEGLPEELKYLALVESGFNPDAVSSAGAAGLWQFMPATAREYGLRVDSWVDERRDPEKSTRAAARYLkDLYKRF---G 77

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1341972516 190 DIELSLAAYNAGAGTVNRARHAALARGEAgEYWQLQLPNETMQYLPKLNAIA 241
Cdd:cd16894    78 DWLLALAAYNAGEGRVRRAIKRAGTDKWE-DYYRLYLPAETRRYVPKFLAAK 128
MltF COG4623
Membrane-bound lytic murein transglycosylase MltF [Cell wall/membrane/envelope biogenesis, ...
 66-244 1.14e-28

Membrane-bound lytic murein transglycosylase MltF [Cell wall/membrane/envelope biogenesis, Signal transduction mechanisms];


Pssm-ID: 443662 [Multi-domain]  Cd Length: 421  Bit Score: 115.54  E-value: 1.14e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1341972516  66 ENLAWQERRHD----ARVQHWIEHYRANP-GNVVE-----------------IIERARPWMAWITEQVERRGLPGE-VSL 122
Cdd:COG4623   205 QPIAWAVRKNDpsllAALNEFFAKIKKGGtLARLYeryfghvkrdtraflrrIEGRLPPYDPLFEKYAEEYGLDWRlLAA 284

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1341972516 123 IPFIESSYDPHARSHRGAAGLWQFMPGTADALGLrrqggyDGRLDVIAATNAALDYIELQAEQWYE-----GDIELSLAA 197
Cdd:COG4623   285 LAYQESHWNPRARSPTGARGLMQLMPATAKELGV------DDRLDPEQSIRAGAKYLRWLYDRFPEaidepDRWWFALAA 358

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1341972516 198 YNAGAGTVNRARHAALARGEAGEYWQLQ-------------LPNETMQYLPKLNAIAAII 244
Cdd:COG4623   359 YNAGPGHVQDARRLAKKQGLDPDRWFDVeksqpkyydtgyaRGRETVNYVPNIRAYYDIY 418
SLT pfam01464
Transglycosylase SLT domain; This family is distantly related to pfam00062. Members are found ...
 106-208 2.00e-21

Transglycosylase SLT domain; This family is distantly related to pfam00062. Members are found in phages, type II, type III and type IV secretion systems.


Pssm-ID: 396169 [Multi-domain]  Cd Length: 114  Bit Score: 88.52  E-value: 2.00e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1341972516 106 WITEQVERRGLPGEVSLIPFIESSYDPHARSHRGAAGLWQFMPGTADALGLRRQGGYDGRLDVIAATNAALDYI-ELQAE 184
Cdd:pfam01464   1 IIKAAQKYGVDPSLLLAIAQQESGFNPKAVSKSGAVGLMQIMPSTAKRLGLRVNPGVDDLFDPEKNIKAGTKYLkELYKQ 80

                          90       100
                  ....*....|....*....|....
gi 1341972516 185 qwYEGDIELSLAAYNAGAGTVNRA 208
Cdd:pfam01464  81 --YGGDLWLALAAYNAGPGRVRKW 102
LysM smart00257
Lysin motif;
336-377 1.92e-10

Lysin motif;


Pssm-ID: 197609 [Multi-domain]  Cd Length: 44  Bit Score: 55.53  E-value: 1.92e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1341972516  336 YLVQRGDSLSAIAARHSISVAELRQHNG-LRGDTIQVGQTLEI 377
Cdd:smart00257   2 YTVKKGDTLSSIARRYGISVSDLLELNNiLDPDNLQVGQKLKI 44
 
Name Accession Description Interval E-value
mltD PRK10783
membrane-bound lytic murein transglycosylase D; Provisional
 31-385 2.77e-90

membrane-bound lytic murein transglycosylase D; Provisional


Pssm-ID: 182727 [Multi-domain]  Cd Length: 456  Bit Score: 279.31  E-value: 2.77e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1341972516  31 LASPHPGATPAFPTHHFW-DDLNLEAMPGDAWERLRENLAwQERRHDARVQHWIEHYRANPGNVVEIIERARPWMAWITE 109
Cdd:PRK10783   32 LSSAGQGEAGKYTSQARWmDDGTSIAPDQDLWAFIGDELK-MGIPENSRIREQKQKYLRNKSYLHDVTLRAEPYMYWIVG 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1341972516 110 QVERRGLPGEVSLIPFIESSYDPHARSHRGAAGLWQFMPGTADALGLRRQGGYDGRLDVIAATNAALDYIElQAEQWYEG 189
Cdd:PRK10783  111 QIKKRNMPMELVLLPIVESAFDPHATSGANAAGIWQIIPSTGRNYGLKQTRWYDARRDVVASTTAALDMMQ-RLNKMFDG 189

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1341972516 190 DIELSLAAYNAGAGTVNRARHAALARGEAGEYWQLQLPNETMQYLPKLNAIAAIIDDPDAYGVALPEIDDAPAFAKVPVN 269
Cdd:PRK10783  190 DWLLTVAAYNSGEGRVMKAIKANKAKGKPTDFWSLSLPRETKIYVPKMLALSDILKNSKRYGVRLPTTDESRALARVDLG 269

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1341972516 270 RPIELSQLARVTGVDASELSALNPGLTNGSANPSTVEVVLVP---VEQEQVVLA--ELSAPAPQA-----PAGDSQYLVQ 339
Cdd:PRK10783  270 QQIELAQAAEMAGMSLTKLKTFNAGYKRSTTAPSGPHYIMVPkkhADQLRESLAsgEIAAVQSTLvadntPLNSRSYKVR 349

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*.
gi 1341972516 340 RGDSLSAIAARHSISVAELRQHNGLRGDTIQVGQTLEIPRRSLAAR 385
Cdd:PRK10783  350 SGDTLSGIASRLNVSTKDLQQWNNLRGSKLKVGQTLTIGAGSSAQR 395
MltD-like cd16894
Membrane-bound lytic murein transglycosylase D and similar proteins; Lytic transglycosylases ...
 111-241 4.87e-44

Membrane-bound lytic murein transglycosylase D and similar proteins; Lytic transglycosylases (LT) catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc). Membrane-bound lytic murein transglycosylase D protein (MltD) family members may have one or more small LysM domains, which may contribute to peptidoglycan binding. Unlike the similar "goose-type" lysozymes, LTs also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue. Proteins similar to this family include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as the eukaryotic "goose-type" lysozymes (goose egg-white lysozyme; GEWL).


Pssm-ID: 381615 [Multi-domain]  Cd Length: 129  Bit Score: 148.82  E-value: 4.87e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1341972516 111 VERRGLPGEVSLIPFIESSYDPHARSHRGAAGLWQFMPGTADALGLRRQGGYDGRLDVIAATNAALDYI-ELQAEQwyeG 189
Cdd:cd16894     1 LLKEGLPEELKYLALVESGFNPDAVSSAGAAGLWQFMPATAREYGLRVDSWVDERRDPEKSTRAAARYLkDLYKRF---G 77

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1341972516 190 DIELSLAAYNAGAGTVNRARHAALARGEAgEYWQLQLPNETMQYLPKLNAIA 241
Cdd:cd16894    78 DWLLALAAYNAGEGRVRRAIKRAGTDKWE-DYYRLYLPAETRRYVPKFLAAK 128
MltF COG4623
Membrane-bound lytic murein transglycosylase MltF [Cell wall/membrane/envelope biogenesis, ...
 66-244 1.14e-28

Membrane-bound lytic murein transglycosylase MltF [Cell wall/membrane/envelope biogenesis, Signal transduction mechanisms];


Pssm-ID: 443662 [Multi-domain]  Cd Length: 421  Bit Score: 115.54  E-value: 1.14e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1341972516  66 ENLAWQERRHD----ARVQHWIEHYRANP-GNVVE-----------------IIERARPWMAWITEQVERRGLPGE-VSL 122
Cdd:COG4623   205 QPIAWAVRKNDpsllAALNEFFAKIKKGGtLARLYeryfghvkrdtraflrrIEGRLPPYDPLFEKYAEEYGLDWRlLAA 284

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1341972516 123 IPFIESSYDPHARSHRGAAGLWQFMPGTADALGLrrqggyDGRLDVIAATNAALDYIELQAEQWYE-----GDIELSLAA 197
Cdd:COG4623   285 LAYQESHWNPRARSPTGARGLMQLMPATAKELGV------DDRLDPEQSIRAGAKYLRWLYDRFPEaidepDRWWFALAA 358

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1341972516 198 YNAGAGTVNRARHAALARGEAGEYWQLQ-------------LPNETMQYLPKLNAIAAII 244
Cdd:COG4623   359 YNAGPGHVQDARRLAKKQGLDPDRWFDVeksqpkyydtgyaRGRETVNYVPNIRAYYDIY 418
MltE COG0741
Soluble lytic murein transglycosylase or regulatory protein s ( may contain LysM/invasin ...
 11-243 4.79e-27

Soluble lytic murein transglycosylase or regulatory protein s ( may contain LysM/invasin domain) [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440504 [Multi-domain]  Cd Length: 244  Bit Score: 107.77  E-value: 4.79e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1341972516  11 LALAGGIAMIGALSATSPALLASPHPGATPAFPTHHFWDDLNLEAMPGDAWERLRENLAWQERRHDARVQHWIEHYRANP 90
Cdd:COG0741    11 LALAASAAAALALALLAAAAAAAALAAAAAALAAAAAAAAGAAAAAASAAAGGPALAAALAAADALAAFAAIAALAAELL 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1341972516  91 GNVVEIIERARPWMAWITEQVERRGLPGE-VSLIPFIESSYDPHARSHRGAAGLWQFMPGTADALGLRRQGGY--DGRLD 167
Cdd:COG0741    91 ALAALLLRRPLPYLPLIEEAAKKYGVDPAlVLALIRQESAFNPNAVSPAGARGLMQLMPATARRLGLKLGLGPspDDLFD 170

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1341972516 168 VIAATNAALDYIELQAEQwYEGDIELSLAAYNAGAGTVNRARhaalaRGEAGEYWQLQLPNETMQYLPKLNAIAAI 243
Cdd:COG0741   171 PETNIRAGAAYLRELLDR-FDGDLVLALAAYNAGPGRVRRWL-----RRNGDRDGEIIPYAETRNYVKKVLANYAI 240
SLT pfam01464
Transglycosylase SLT domain; This family is distantly related to pfam00062. Members are found ...
 106-208 2.00e-21

Transglycosylase SLT domain; This family is distantly related to pfam00062. Members are found in phages, type II, type III and type IV secretion systems.


Pssm-ID: 396169 [Multi-domain]  Cd Length: 114  Bit Score: 88.52  E-value: 2.00e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1341972516 106 WITEQVERRGLPGEVSLIPFIESSYDPHARSHRGAAGLWQFMPGTADALGLRRQGGYDGRLDVIAATNAALDYI-ELQAE 184
Cdd:pfam01464   1 IIKAAQKYGVDPSLLLAIAQQESGFNPKAVSKSGAVGLMQIMPSTAKRLGLRVNPGVDDLFDPEKNIKAGTKYLkELYKQ 80

                          90       100
                  ....*....|....*....|....
gi 1341972516 185 qwYEGDIELSLAAYNAGAGTVNRA 208
Cdd:pfam01464  81 --YGGDLWLALAAYNAGPGRVRKW 102
LysM COG1388
LysM repeat [Cell wall/membrane/envelope biogenesis];
251-380 1.32e-16

LysM repeat [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440998 [Multi-domain]  Cd Length: 156  Bit Score: 76.67  E-value: 1.32e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1341972516 251 GVALPEIDDAPAFAKVPVNRPIELSQLARVTGVDASELSALNPGLTNGSANPSTVEVVLVPVEQEQVVLAELSAPA---- 326
Cdd:COG1388     1 GLLLALSANAALLAAVLTLLAALLLLAAALAAVALLLLAALAPAGLSLAAALNGEALLLLLPAAAAAAKAALAAAPeaaa 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1341972516 327 ----------------------PQAPAGDSQYLVQRGDSLSAIAARHSISVAELRQHNGLRGDTIQVGQTLEIPRR 380
Cdd:COG1388    81 aaaarytvksgdtlsgiarrygAAAAPSPVTYTVKKGDTLWSIARRYGVSVEELKRWNGLSSDTIRPGQKLKIPAS 156
LT-like cd00254
lytic transglycosylase(LT)-like domain; Members include the soluble and insoluble ...
 127-209 7.95e-16

lytic transglycosylase(LT)-like domain; Members include the soluble and insoluble membrane-bound LTs in bacteria and LTs in bacteriophage lambda. LTs catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue.


Pssm-ID: 381594 [Multi-domain]  Cd Length: 111  Bit Score: 72.63  E-value: 7.95e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1341972516 127 ESSYDPHARSHRGAAGLWQFMPGTADALGLRRQggyDGRLDVIAATNAALDYIELQAEQWYeGDIELSLAAYNAGAGTVN 206
Cdd:cd00254    11 ESGFNPRAVSPAGARGLMQLMPGTARDLGRRGV---DDLFDPEENIRAGARYLRELLDRFG-GDLELALAAYNAGPGAVD 86


                  ...
gi 1341972516 207 RAR 209
Cdd:cd00254    87 RWG 89
LysM pfam01476
LysM domain; The LysM (lysin motif) domain is about 40 residues long. It is found in a variety ...
 336-378 7.75e-14

LysM domain; The LysM (lysin motif) domain is about 40 residues long. It is found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function. The structure of this domain is known.


Pssm-ID: 396179 [Multi-domain]  Cd Length: 43  Bit Score: 65.11  E-value: 7.75e-14
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1341972516 336 YLVQRGDSLSAIAARHSISVAELRQHNGLRGDTIQVGQTLEIP 378
Cdd:pfam01476   1 YTVKKGDTLSSIAKRYGITVEQLAELNGLSSPNLYVGQKLKIP 43
MLTF-like cd13403
membrane-bound lytic murein transglycosylase F (MLTF) and similar proteins; This subfamily ...
 127-215 2.65e-13

membrane-bound lytic murein transglycosylase F (MLTF) and similar proteins; This subfamily includes membrane-bound lytic murein transglycosylase F (MltF, murein lyase F) that degrades murein glycan strands. It is responsible for catalyzing the release of 1,6-anhydromuropeptides from peptidoglycan. Lytic transglycosylase catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc) as do goose-type lysozymes. However, in addition, it also makes a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue.


Pssm-ID: 381606 [Multi-domain]  Cd Length: 161  Bit Score: 67.17  E-value: 2.65e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1341972516 127 ESSYDPHARSHRGAAGLWQFMPGTADALGLRRqggydgRLDVIAATNAALDYIELQAEQWYEGD-----IELSLAAYNAG 201
Cdd:cd13403    22 ESRFNPNARSPAGARGLMQLMPSTARELGVND------RLDPEQNIHAGAKYLRYLRDRFPPDIdepdrLKFALAAYNAG 95

                          90
                  ....*....|....
gi 1341972516 202 AGTVNRARhaALAR 215
Cdd:cd13403    96 PGHVRDAR--RLAK 107
Slt70-like cd13401
70kDa soluble lytic transglycosylase (Slt70) and similar proteins; Catalytic domain of the ...
 101-207 4.53e-13

70kDa soluble lytic transglycosylase (Slt70) and similar proteins; Catalytic domain of the 70kda soluble lytic transglycosylase (LT)-like proteins, which also have an N-terminal U-shaped U-domain and a linker L-domain. LTs catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue. Proteins similar to this family include the soluble and insoluble membrane-bound LTs in bacteria and the LTs in bacteriophage lambda.


Pssm-ID: 381604 [Multi-domain]  Cd Length: 152  Bit Score: 66.35  E-value: 4.53e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1341972516 101 RPWMAWITEQVERRGLPgeVSLIPFI---ESSYDPHARSHRGAAGLWQFMPGTADALGlRRQG--GYDGRLDVIAATNAA 175
Cdd:cd13401     4 LPYRDLVERAAKKNGLD--PALVYAIirqESAFDPDAVSPAGALGLMQLMPATAKDVA-KKLGlpYYSPRDLFDPEYNIR 80

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1341972516 176 L--DYI-ELQAEqwYEGDIELSLAAYNAGAGTVNR 207
Cdd:cd13401    81 LgsAYLaELLDR--FDGNPVLALAAYNAGPGRVRR 113
LysM cd00118
Lysin Motif is a small domain involved in binding peptidoglycan; LysM, a small globular domain ...
 336-377 5.60e-12

Lysin Motif is a small domain involved in binding peptidoglycan; LysM, a small globular domain with approximately 40 amino acids, is a widespread protein module involved in binding peptidoglycan in bacteria and chitin in eukaryotes. The domain was originally identified in enzymes that degrade bacterial cell walls, but proteins involved in many other biological functions also contain this domain. It has been reported that the LysM domain functions as a signal for specific plant-bacteria recognition in bacterial pathogenesis. Many of these enzymes are modular and are composed of catalytic units linked to one or several repeats of LysM domains. LysM domains are found in bacteria and eukaryotes.


Pssm-ID: 212030 [Multi-domain]  Cd Length: 45  Bit Score: 59.81  E-value: 5.60e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1341972516 336 YLVQRGDSLSAIAARHSISVAELRQHNGLRG-DTIQVGQTLEI 377
Cdd:cd00118     3 YTVKPGDTLWSIAKKYGVTVEELAAANPLINpDCIYPGQKLKI 45
LT_Slt70-like cd16896
uncharacterized lytic transglycosylase subfamily with similarity to Slt70; Uncharacterized ...
 127-207 2.34e-11

uncharacterized lytic transglycosylase subfamily with similarity to Slt70; Uncharacterized lytic transglycosylase (LT) with a conserved sequence pattern suggesting similarity to the Slt70, a 70kda soluble lytic transglycosylase which also has an N-terminal U-shaped U-domain and a linker L-domain. LTs catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue.


Pssm-ID: 381617 [Multi-domain]  Cd Length: 146  Bit Score: 60.99  E-value: 2.34e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1341972516 127 ESSYDPHARSHRGAAGLWQFMPGTADalGLRRQGGYDGRLD---VIAATNaaldyIELQAeqWY--------EGDIELSL 195
Cdd:cd16896    29 ESNFNPNAVSSKGAIGLMQIMPETAE--WIAEKLGLEDFSEddlYDPETN-----IRLGT--WYlsyllkefDGNLVLAL 99

                          90
                  ....*....|..
gi 1341972516 196 AAYNAGAGTVNR 207
Cdd:cd16896   100 AAYNAGPGNVDK 111
LysM smart00257
Lysin motif;
336-377 1.92e-10

Lysin motif;


Pssm-ID: 197609 [Multi-domain]  Cd Length: 44  Bit Score: 55.53  E-value: 1.92e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1341972516  336 YLVQRGDSLSAIAARHSISVAELRQHNG-LRGDTIQVGQTLEI 377
Cdd:smart00257   2 YTVKKGDTLSSIARRYGISVSDLLELNNiLDPDNLQVGQKLKI 44
Slt35-like cd13399
Slt35-like lytic transglycosylase; Lytic transglycosylase similar to Escherichia coli lytic ...
 126-212 7.73e-09

Slt35-like lytic transglycosylase; Lytic transglycosylase similar to Escherichia coli lytic transglycosylase Slt35 and Pseudomonas aeruginosa Sltb1. Lytic transglycosylase (LT) catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc) as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue. Proteins similar to this this family include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as the eukaryotic "goose-type" lysozymes (goose egg-white lysozyme; GEWL).


Pssm-ID: 381602 [Multi-domain]  Cd Length: 108  Bit Score: 53.08  E-value: 7.73e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1341972516 126 IESSYDPHA-RSHRGAAGLWQFMPGTADALGLrrQGGYDGR------LDVIAATNAALDYIELQAEQWYEGDIELSLAAY 198
Cdd:cd13399    14 VESGFGPNAgGSPAGAQGIAQFMPSTWKAYGV--DGNGDGKadpfnpEDAIASAANYLCRHGWDLNAFLGEDNFLALAAY 91

                          90
                  ....*....|....*
gi 1341972516 199 NAG-AGTVNRARHAA 212
Cdd:cd13399    92 NAGpGAYANAVLELA 106
LT_MltC_MltE cd16893
membrane-bound lytic murein transglycosylases MltC and MltE, and similar proteins; MltC and ...
 105-239 1.61e-08

membrane-bound lytic murein transglycosylases MltC and MltE, and similar proteins; MltC and MltE are periplasmic, outer membrane attached lytic transglycosylases (LTs), which cleave beta-1,4-glycosidic bonds joining N-acetylmuramic acid and N-acetylglucosamine in the cell wall peptidoglycan, yielding 1,6-anhydromuropeptides. Proteins similar to this family include the soluble and insoluble membrane-bound LTs in bacteria and the LTs in bacteriophage lambda


Pssm-ID: 381614 [Multi-domain]  Cd Length: 162  Bit Score: 53.33  E-value: 1.61e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1341972516 105 AWITEQVERRGLpgEVSLIPFI---ESSYDPHARSHRGAAGLWQFMPGTA--DAlgLRRQGGYDGRL--DVI--AATN-- 173
Cdd:cd16893     1 PIVEKYAKKYGV--DPALILAIietESSFNPYAVSHSPAYGLMQIVPSTAgrDV--YRLLGGKGGLPskSYLfdPENNid 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1341972516 174 --AALDYIeLQAEqwYEGDIE-------LSLAAYNAGAGTVNRA----RHAALAR----GEAGEYWQL--QLPN-ETMQY 233
Cdd:cd16893    77 igTAYLHI-LQNR--YLKGIKnpksreyCAIAAYNGGAGNVLRTfssdRKKAISKinrlSPDEVYQHLtkKLPAaETRNY 153


                  ....*.
gi 1341972516 234 LPKLNA 239
Cdd:cd16893   154 LKKVLK 159
PHA00368 PHA00368
internal virion protein D
 125-241 3.98e-08

internal virion protein D


Pssm-ID: 222785 [Multi-domain]  Cd Length: 1315  Bit Score: 55.56  E-value: 3.98e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1341972516  125 FIESSYDPHARSHRGAAGLWQFMPGTADALGLRRQGgyDGRLDVIAATNAALDYIElQAEQWYEGDiELSLA-AYNAGAG 203
Cdd:PHA00368    34 WDESRFNPTAKSPTGPKGLMQFTKATAKALGLIVDD--DDRLDPELAIDAGARYLA-DLVGKYDGD-ELKAAlAYNQGEG 109

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 1341972516  204 TVNRARHAALARGEAGeywqlQLPNETMQYLPKLNAIA 241
Cdd:PHA00368   110 RLGAPQLEAYDKGDFA-----SISEEGRNYLRNLLDVA 142
XkdP COG1652
Cytoplasmic potassium-binding protein Kbp/XkdP/YgaU, contains LysM domain [Inorganic ion ...
 239-379 3.52e-06

Cytoplasmic potassium-binding protein Kbp/XkdP/YgaU, contains LysM domain [Inorganic ion transport and metabolism];


Pssm-ID: 441258 [Multi-domain]  Cd Length: 163  Bit Score: 46.92  E-value: 3.52e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1341972516 239 AIAAIIDDPDAYGVALPEIDDAPAFAKVPVNRPIELSQLARVTGVDASELSALNPGLTNGSANPSTVEVVLVPVEQEQVV 318
Cdd:COG1652    21 AATVLALAAAAALAVVAGLGAAVGAGGALAAALPLAAGLAAAVAAAAAAAVLIAPVAVMRAGAAAKLSPAVTVAEEAAAP 100

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1341972516 319 LAELSAPAPQapagdsQYLVQRGDSLSAIAARH---SISVAELRQHNGLR---GDTIQVGQTLEIPR 379
Cdd:COG1652   101 SAELAPDAPK------TYTVKPGDTLWGIAKRFygdPARWPEIAEANRDQiknPDLIYPGQVLRIPA 161
PRK06347 PRK06347
1,4-beta-N-acetylmuramoylhydrolase;
323-377 7.29e-06

1,4-beta-N-acetylmuramoylhydrolase;


Pssm-ID: 180536 [Multi-domain]  Cd Length: 592  Bit Score: 47.77  E-value: 7.29e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1341972516 323 SAPAPQAPAGDSQYLVQRGDSLSAIAARHSISVAELRQHNGLRGDTIQVGQTLEI 377
Cdd:PRK06347  395 SKPSTGTSTNAKVYTVVKGDSLWRIANNNKVTIANLKSWNNLKSDFIYPGQKLKV 449
PRK11619 PRK11619
lytic murein transglycosylase; Provisional
 127-207 9.77e-06

lytic murein transglycosylase; Provisional


Pssm-ID: 183236 [Multi-domain]  Cd Length: 644  Bit Score: 47.75  E-value: 9.77e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1341972516 127 ESSYDPHARSHRGAAGLWQFMPGTA-DALGLRRQGGYDGR---LDVIAATNAALDYIELQAEQWYEGDIeLSLAAYNAGA 202
Cdd:PRK11619  504 ESAWNPKARSPVGASGLMQIMPGTAtHTVKMFSIPGYSSSsqlLDPETNINIGTSYLEYVYQQFGNNRI-LASAAYNAGP 582


                  ....*
gi 1341972516 203 GTVNR 207
Cdd:PRK11619  583 GRVRT 587
Lyz-like cd00442
lysozyme-like domains; This family contains several members, including soluble lytic ...
 122-178 1.39e-05

lysozyme-like domains; This family contains several members, including soluble lytic transglycosylases (SLT), goose egg-white lysozymes (GEWL), hen egg-white lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, chitosanases, and pesticin. Typical members are involved in the hydrolysis of beta-1,4- linked polysaccharides.


Pssm-ID: 381596 [Multi-domain]  Cd Length: 59  Bit Score: 42.40  E-value: 1.39e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1341972516 122 LIPFIESSYDPHAR--SHRGAAGLWQFMPGTADALGLRrqgGYDGRLDVIAATNAALDY 178
Cdd:cd00442     4 AIIGQESGGNKPANagSGSGAAGLFQFMPGTWKAYGKN---SSSDLNDPEASIEAAAKY 59
PRK06347 PRK06347
1,4-beta-N-acetylmuramoylhydrolase;
323-377 1.67e-05

1,4-beta-N-acetylmuramoylhydrolase;


Pssm-ID: 180536 [Multi-domain]  Cd Length: 592  Bit Score: 47.00  E-value: 1.67e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1341972516 323 SAPAPQAPAGDSQYLVQRGDSLSAIAARHSISVAELRQHNGLRGDTIQVGQTLEI 377
Cdd:PRK06347  469 SKPSTNTNTNAKVYTVAKGDSLWRIANNNKVTIANLKSWNNLKSDFIYPGQKLKV 523
PRK06347 PRK06347
1,4-beta-N-acetylmuramoylhydrolase;
336-377 1.86e-05

1,4-beta-N-acetylmuramoylhydrolase;


Pssm-ID: 180536 [Multi-domain]  Cd Length: 592  Bit Score: 46.61  E-value: 1.86e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1341972516 336 YLVQRGDSLSAIAARHSISVAELRQHNGLRGDTIQVGQTLEI 377
Cdd:PRK06347  333 YTVVKGDSLWRIANNHKVTVANLKAWNNLKSDFIYPGQKLKV 374
OapA COG3061
Cell division protein YtfB/OapA (opacity-associated protein A) [Cell cycle control, cell ...
 299-377 5.63e-05

Cell division protein YtfB/OapA (opacity-associated protein A) [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442295 [Multi-domain]  Cd Length: 425  Bit Score: 45.04  E-value: 5.63e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1341972516 299 SANPSTVEVVLVPVEQEQVVLA-ELSAP-APQAPAGDSQ-YLVQRGDSLSAIAARHSISVAELRQ-------HNGLRgdT 368
Cdd:COG3061    32 DASASRVSQPLVPLALTAEADApAAAAPaAPAAPEGEWQeYTVQSGDTLSQIFRRLGLSASDLYAllaaegdAKPLS--R 109


                  ....*....
gi 1341972516 369 IQVGQTLEI 377
Cdd:COG3061   110 LKPGQELRF 118
PHA00658 PHA00658
putative lysin
 136-236 8.56e-05

putative lysin


Pssm-ID: 106967 [Multi-domain]  Cd Length: 720  Bit Score: 44.81  E-value: 8.56e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1341972516 136 SHRGAAGLWQFMPGTA-DALGLRRQGGYDGRLDVIAATNAALDYIELQAE-QWYEGDIELSLAAYNAGAGtvnrARHAAL 213
Cdd:PHA00658  326 SPKGAVGIAQVMPDTApEAAKLAGLPWDENRYRNDAAYNRALGMAYFQKQlRDFGGDLPKAYAAYNAGPG----ALQSAL 401

                          90       100
                  ....*....|....*....|...
gi 1341972516 214 ARGEAGEyWQLQLPNETMQYLPK 236
Cdd:PHA00658  402 KDAKDGN-WLALLPKETQDYVVK 423
mltC PRK11671
membrane-bound lytic murein transglycosylase MltC;
99-207 1.66e-04

membrane-bound lytic murein transglycosylase MltC;


Pssm-ID: 183271 [Multi-domain]  Cd Length: 359  Bit Score: 43.12  E-value: 1.66e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1341972516  99 RARPWMAWITEQVERRGLpgEVSLIPFI---ESSYDPHARSHRGAAGLWQFMPGTA--DALGLRRQGGYDGR---LDVIA 170
Cdd:PRK11671  188 RAHKYLPMVRKASRKYGV--DESLILAImqtESSFNPYAVSRSDALGLMQVVQHTAgkDVFRMKGKSGQPSRsylFDPAN 265

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1341972516 171 ATNAALDYIE-LQAEqwYEGDIE-------LSLAAYNAGAGTVNR 207
Cdd:PRK11671  266 NIDTGTAYLAiLQNV--YLGGITnptsrryAVITAYNGGAGSVLR 308
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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