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MULTISPECIES: GntR family transcriptional regulator [Enterococcus]

Protein Classification

GntR family transcriptional regulator( domain architecture ID 11450764)

GntR-family transcriptional regulator is one of a group of transcriptional regulators with a conserved N-terminal helix-turn-helix DNA-binding domain and a diverse C-terminal effector-binding and oligomerization domain

Gene Ontology:  GO:0003677|GO:0003700
PubMed:  2060763|26172911|33509775|15808743

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
7-231 1.08e-48

DNA-binding transcriptional regulator, GntR family [Transcription];


:

Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 159.64  E-value: 1.08e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352495636   7 LYLEVADKIKEDIFSGKYPVGTMLPTENELEELFQVSKITVRKAIELLATDEYVEKKSGRGTTVLSNRPYNRLSKAASFT 86
Cdd:COG2188     6 LYLQIADALRERIESGELPPGDRLPSERELAEEFGVSRMTVRKALDELVEEGLLERRQGRGTFVAEPKIEYPLSRLTSFT 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352495636  87 QILENSQYEVRKETLELKKV----------DLKKDDPLYgyfgsyatRFKRLYYLNDEPYIYFIHYLPSEMI-RVRRKEF 155
Cdd:COG2188    86 EELRARGREPSTRVLSAERVpadeevaealGLPPGAPVL--------RIERLRLADGEPVALETSYLPAALFpGLLEEDL 157

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1352495636 156 DEESLYRLLTQK-GEYIDVFSDDFSAIFLSEKEQEILKTSA-QIGIKRIRRSSNQQGEILEYSEAIYHTDLHPYHIDY 231
Cdd:COG2188   158 ETGSLYELLEERyGLRITRAEQRIEAVLADAEEAELLGVPPgAPVLVIERVTYDADGRPVEYSRSYYRGDRYRFVVEL 235
 
Name Accession Description Interval E-value
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
7-231 1.08e-48

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 159.64  E-value: 1.08e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352495636   7 LYLEVADKIKEDIFSGKYPVGTMLPTENELEELFQVSKITVRKAIELLATDEYVEKKSGRGTTVLSNRPYNRLSKAASFT 86
Cdd:COG2188     6 LYLQIADALRERIESGELPPGDRLPSERELAEEFGVSRMTVRKALDELVEEGLLERRQGRGTFVAEPKIEYPLSRLTSFT 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352495636  87 QILENSQYEVRKETLELKKV----------DLKKDDPLYgyfgsyatRFKRLYYLNDEPYIYFIHYLPSEMI-RVRRKEF 155
Cdd:COG2188    86 EELRARGREPSTRVLSAERVpadeevaealGLPPGAPVL--------RIERLRLADGEPVALETSYLPAALFpGLLEEDL 157

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1352495636 156 DEESLYRLLTQK-GEYIDVFSDDFSAIFLSEKEQEILKTSA-QIGIKRIRRSSNQQGEILEYSEAIYHTDLHPYHIDY 231
Cdd:COG2188   158 ETGSLYELLEERyGLRITRAEQRIEAVLADAEEAELLGVPPgAPVLVIERVTYDADGRPVEYSRSYYRGDRYRFVVEL 235
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 7-70 4.03e-21

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 83.27  E-value: 4.03e-21
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1352495636   7 LYLEVADKIKEDIFSGKYPVGTMLPTENELEELFQVSKITVRKAIELLATDEYVEKKSGRGTTV 70
Cdd:cd07377     2 LYEQIADQLREAILSGELKPGDRLPSERELAEELGVSRTTVREALRELEAEGLVERRPGRGTFV 65
PRK09764 PRK09764
GntR family transcriptional regulator;
7-223 2.25e-17

GntR family transcriptional regulator;


Pssm-ID: 182065 [Multi-domain]  Cd Length: 240  Bit Score: 77.95  E-value: 2.25e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352495636   7 LYLEVADKIKEDIFSGKYPVGTMLPTENELEELFQVSKITVRKAIELLATDEYVEKKSGRGTTVLSNRPYNRLSKAASFT 86
Cdd:PRK09764    6 LYRQIADRIREQIARGELKPGDALPTESALQTEFGVSRVTVRQALRQLVEQQILESIQGSGTYVKEERVNYDIFQLTSFD 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352495636  87 QILENSQYEVRKETL--ELKKVDLKKDDPLYGYFGSYATRFKRLYYLNDEPYIYFIHYLPSEMIRVRRKEFDEESLYRLL 164
Cdd:PRK09764   86 EKLSDRHVDTHSEVLifEVIPADDFLQQQLQITAQDRVWHVKRVRYRKQKPMALEETWMPLALFPDLTWQVMENSKYHFI 165

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1352495636 165 TQ-KGEYIDVFSDDFSAIFLSEKEQEILKTS-AQIGIKRIRRSSNQQGEILEYSEAIYHTD 223
Cdd:PRK09764  166 EEvKKMVIDRSEQEIIPLMPTEEMSRLLNISqTKPILEKVSRGYLVDGRVFEYSRNAFNTD 226
GntR pfam00392
Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the ...
 7-70 3.17e-17

Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the N-terminal HTH region of GntR-like bacterial transcription factors. At the C-terminus there is usually an effector-binding/oligomerization domain. The GntR-like proteins include the following sub-families: MocR, YtrR, FadR, AraR, HutC and PlmA, DevA, DasR. Many of these proteins have been shown experimentally to be autoregulatory, enabling the prediction of operator sites and the discovery of cis/trans relationships. The DasR regulator has been shown to be a global regulator of primary metabolism and development in Streptomyces coelicolor.


Pssm-ID: 306822 [Multi-domain]  Cd Length: 64  Bit Score: 73.03  E-value: 3.17e-17
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1352495636   7 LYLEVADKIKEDIFSGKYPVGTMLPTENELEELFQVSKITVRKAIELLATDEYVEKKSGRGTTV 70
Cdd:pfam00392   1 LYEQVYARLREDILSGRLRPGDKLPSERELAAEFGVSRTTVREALRRLEAEGLVERRQGRGTFV 64
C_P_lyase_phnF TIGR02325
phosphonates metabolism transcriptional regulator PhnF; All members of the seed alignment for ...
 7-102 1.26e-16

phosphonates metabolism transcriptional regulator PhnF; All members of the seed alignment for this family are predicted helix-turn-helix transcriptional regulatory proteins of the broader gntR and are found associated with genes for the import and degradation of phosphonates and/or related compounds (e.g. phosphonites) with a direct C-P bond. [Transport and binding proteins, Anions, Regulatory functions, DNA interactions]


Pssm-ID: 131378 [Multi-domain]  Cd Length: 238  Bit Score: 75.98  E-value: 1.26e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352495636   7 LYLEVADKIKEDIFSGKYPVGTMLPTENELEELFQVSKITVRKAIELLATDEYVEKKSGRGTTVLSNRPYNRLSKAASFT 86
Cdd:TIGR02325   9 LWRQIADKIEQEIAAGHLRAGDYLPAEMQLAERFGVNRHTVRRAIAALVERGLLRAEQGRGTFVAARRIDYPLSARTRFS 88

                          90
                  ....*....|....*.
gi 1352495636  87 QILENSQYEVRKETLE 102
Cdd:TIGR02325  89 QNLADQGREPTGELLL 104
HTH_GNTR smart00345
helix_turn_helix gluconate operon transcriptional repressor;
11-70 2.31e-14

helix_turn_helix gluconate operon transcriptional repressor;


Pssm-ID: 197669 [Multi-domain]  Cd Length: 60  Bit Score: 65.29  E-value: 2.31e-14
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352495636   11 VADKIKEDIFSGKYPVGTMLPTENELEELFQVSKITVRKAIELLATDEYVEKKSGRGTTV 70
Cdd:smart00345   1 VAERLREDIVSGELRPGDKLPSERELAAQLGVSRTTVREALSRLEAEGLVQRRPGSGTFV 60
 
Name Accession Description Interval E-value
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
7-231 1.08e-48

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 159.64  E-value: 1.08e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352495636   7 LYLEVADKIKEDIFSGKYPVGTMLPTENELEELFQVSKITVRKAIELLATDEYVEKKSGRGTTVLSNRPYNRLSKAASFT 86
Cdd:COG2188     6 LYLQIADALRERIESGELPPGDRLPSERELAEEFGVSRMTVRKALDELVEEGLLERRQGRGTFVAEPKIEYPLSRLTSFT 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352495636  87 QILENSQYEVRKETLELKKV----------DLKKDDPLYgyfgsyatRFKRLYYLNDEPYIYFIHYLPSEMI-RVRRKEF 155
Cdd:COG2188    86 EELRARGREPSTRVLSAERVpadeevaealGLPPGAPVL--------RIERLRLADGEPVALETSYLPAALFpGLLEEDL 157

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1352495636 156 DEESLYRLLTQK-GEYIDVFSDDFSAIFLSEKEQEILKTSA-QIGIKRIRRSSNQQGEILEYSEAIYHTDLHPYHIDY 231
Cdd:COG2188   158 ETGSLYELLEERyGLRITRAEQRIEAVLADAEEAELLGVPPgAPVLVIERVTYDADGRPVEYSRSYYRGDRYRFVVEL 235
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 7-70 4.03e-21

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 83.27  E-value: 4.03e-21
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1352495636   7 LYLEVADKIKEDIFSGKYPVGTMLPTENELEELFQVSKITVRKAIELLATDEYVEKKSGRGTTV 70
Cdd:cd07377     2 LYEQIADQLREAILSGELKPGDRLPSERELAEELGVSRTTVREALRELEAEGLVERRPGRGTFV 65
FadR COG2186
DNA-binding transcriptional regulator, FadR family [Transcription];
1-102 1.41e-18

DNA-binding transcriptional regulator, FadR family [Transcription];


Pssm-ID: 441789 [Multi-domain]  Cd Length: 232  Bit Score: 81.13  E-value: 1.41e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352495636   1 MKRTRiLYLEVADKIKEDIFSGKYPVGTMLPTENELEELFQVSKITVRKAIELLATDEYVEKKSGRGTTVLSNRPyNRLS 80
Cdd:COG2186     3 IRRRS-LAEQVAEQLRELILSGELKPGDRLPSERELAEQLGVSRTTVREALRALEALGLVEVRQGGGTFVREPSP-WALL 80

                          90       100
                  ....*....|....*....|....*.
gi 1352495636  81 KAASFTQILENSQ----YEVRkETLE 102
Cdd:COG2186    81 DPLALLLALDDASlrdlLEAR-LALE 105
PRK09764 PRK09764
GntR family transcriptional regulator;
7-223 2.25e-17

GntR family transcriptional regulator;


Pssm-ID: 182065 [Multi-domain]  Cd Length: 240  Bit Score: 77.95  E-value: 2.25e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352495636   7 LYLEVADKIKEDIFSGKYPVGTMLPTENELEELFQVSKITVRKAIELLATDEYVEKKSGRGTTVLSNRPYNRLSKAASFT 86
Cdd:PRK09764    6 LYRQIADRIREQIARGELKPGDALPTESALQTEFGVSRVTVRQALRQLVEQQILESIQGSGTYVKEERVNYDIFQLTSFD 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352495636  87 QILENSQYEVRKETL--ELKKVDLKKDDPLYGYFGSYATRFKRLYYLNDEPYIYFIHYLPSEMIRVRRKEFDEESLYRLL 164
Cdd:PRK09764   86 EKLSDRHVDTHSEVLifEVIPADDFLQQQLQITAQDRVWHVKRVRYRKQKPMALEETWMPLALFPDLTWQVMENSKYHFI 165

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1352495636 165 TQ-KGEYIDVFSDDFSAIFLSEKEQEILKTS-AQIGIKRIRRSSNQQGEILEYSEAIYHTD 223
Cdd:PRK09764  166 EEvKKMVIDRSEQEIIPLMPTEEMSRLLNISqTKPILEKVSRGYLVDGRVFEYSRNAFNTD 226
PRK11402 PRK11402
transcriptional regulator PhoB;
7-230 2.57e-17

transcriptional regulator PhoB;


Pssm-ID: 183118 [Multi-domain]  Cd Length: 241  Bit Score: 77.95  E-value: 2.57e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352495636   7 LYLEVADKIKEDIFSGKYPVGTMLPTENELEELFQVSKITVRKAIELLATDEYVEKKSGRGTTVLSNRPYNRLSKAASFT 86
Cdd:PRK11402   10 LYATVRQRLLDDIAQGVYQAGQQIPTENELCTQYNVSRITIRKAISDLVADGVLIRWQGKGTFVQSQKVENALLTVSGFT 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352495636  87 QILENSQYEVRKETLELKKVDLKK-DDPLYGYFGSYATRFKRLYYLNDEPYIYFIHYLPSEmirvRRKEFDE-----ESL 160
Cdd:PRK11402   90 DFGVSQGKATKEKVIEQERVSAAPfCEKLNIPGNSEVFHLCRVMYLDKEPLFIDSSWIPLS----RYPDFDEiyvegSST 165

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1352495636 161 YRLLTQKGEYIDVFSDDFSAIFLSEKEQ-EILKTSAQIGIKRIRRSS-NQQGEILEYSEAIYHTDLHPYHID 230
Cdd:PRK11402  166 YQLFQERFDTRVVSDKKTIDIFAATRPEaKWLKCELGEPLFRISKIAfDQNDKPVHVSELFCRANRVTLTID 237
GntR pfam00392
Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the ...
 7-70 3.17e-17

Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the N-terminal HTH region of GntR-like bacterial transcription factors. At the C-terminus there is usually an effector-binding/oligomerization domain. The GntR-like proteins include the following sub-families: MocR, YtrR, FadR, AraR, HutC and PlmA, DevA, DasR. Many of these proteins have been shown experimentally to be autoregulatory, enabling the prediction of operator sites and the discovery of cis/trans relationships. The DasR regulator has been shown to be a global regulator of primary metabolism and development in Streptomyces coelicolor.


Pssm-ID: 306822 [Multi-domain]  Cd Length: 64  Bit Score: 73.03  E-value: 3.17e-17
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1352495636   7 LYLEVADKIKEDIFSGKYPVGTMLPTENELEELFQVSKITVRKAIELLATDEYVEKKSGRGTTV 70
Cdd:pfam00392   1 LYEQVYARLREDILSGRLRPGDKLPSERELAAEFGVSRTTVREALRRLEAEGLVERRQGRGTFV 64
C_P_lyase_phnF TIGR02325
phosphonates metabolism transcriptional regulator PhnF; All members of the seed alignment for ...
 7-102 1.26e-16

phosphonates metabolism transcriptional regulator PhnF; All members of the seed alignment for this family are predicted helix-turn-helix transcriptional regulatory proteins of the broader gntR and are found associated with genes for the import and degradation of phosphonates and/or related compounds (e.g. phosphonites) with a direct C-P bond. [Transport and binding proteins, Anions, Regulatory functions, DNA interactions]


Pssm-ID: 131378 [Multi-domain]  Cd Length: 238  Bit Score: 75.98  E-value: 1.26e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352495636   7 LYLEVADKIKEDIFSGKYPVGTMLPTENELEELFQVSKITVRKAIELLATDEYVEKKSGRGTTVLSNRPYNRLSKAASFT 86
Cdd:TIGR02325   9 LWRQIADKIEQEIAAGHLRAGDYLPAEMQLAERFGVNRHTVRRAIAALVERGLLRAEQGRGTFVAARRIDYPLSARTRFS 88

                          90
                  ....*....|....*.
gi 1352495636  87 QILENSQYEVRKETLE 102
Cdd:TIGR02325  89 QNLADQGREPTGELLL 104
UTRA pfam07702
UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ...
 86-225 8.02e-15

UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain that has a similar fold to pfam04345. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules sugar phosphates and urocanate, Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 429607 [Multi-domain]  Cd Length: 141  Bit Score: 68.78  E-value: 8.02e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352495636  86 TQILENSQYEVRKEtlELKKVDLKKDDPLYgyfgsyatRFKRLYYLNDEPYIYFIHYLPSEMIR-VRRKEFDEESLYRLL 164
Cdd:pfam07702   8 TEVLSLEEVPASAE--IAEALGLPPGEPVY--------RIERLRYADGEPVALEEDYLPAELVPdLLEEDLEEGSLYDYL 77

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1352495636 165 TQK-GEYIDVFSDDFSAIFLSEKEQEILKTSA-QIGIKRIRRSSNQQGEILEYSEAIYHTDLH 225
Cdd:pfam07702  78 EERyGLPITRAEQTIEAVLADAEEAELLGISPgAPVLLIERVTYDQDGRPVEYSRSYYRGDRY 140
HTH_GNTR smart00345
helix_turn_helix gluconate operon transcriptional repressor;
11-70 2.31e-14

helix_turn_helix gluconate operon transcriptional repressor;


Pssm-ID: 197669 [Multi-domain]  Cd Length: 60  Bit Score: 65.29  E-value: 2.31e-14
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352495636   11 VADKIKEDIFSGKYPVGTMLPTENELEELFQVSKITVRKAIELLATDEYVEKKSGRGTTV 70
Cdd:smart00345   1 VAERLREDIVSGELRPGDKLPSERELAAQLGVSRTTVREALSRLEAEGLVQRRPGSGTFV 60
YhcF COG1725
DNA-binding transcriptional regulator YhcF, GntR family [Transcription];
7-98 2.15e-13

DNA-binding transcriptional regulator YhcF, GntR family [Transcription];


Pssm-ID: 441331 [Multi-domain]  Cd Length: 114  Bit Score: 64.43  E-value: 2.15e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352495636   7 LYLEVADKIKEDIFSGKYPVGTMLPTENELEELFQVSKITVRKAIELLATDEYVEKKSGRGTTVLS-NRPYNRLSKAASF 85
Cdd:COG1725    11 IYEQIADQIKEAIASGELKPGDRLPSVRELAAELGVNPNTVAKAYRELEDEGLIETRRGKGTFVAEdARELLEERREEFL 90

                          90
                  ....*....|...
gi 1352495636  86 TQILENSQYEVRK 98
Cdd:COG1725    91 EEALRELVAEARR 103
UTRA smart00866
The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; ...
 86-225 2.93e-12

The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; It has a similar fold to HutC/FarR-like bacterial transcription factors of the GntR family. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules.


Pssm-ID: 214869 [Multi-domain]  Cd Length: 143  Bit Score: 61.93  E-value: 2.93e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352495636   86 TQILEnsqYEVRKETLEL-KKVDLKKDDPLYgyfgsyatRFKRLYYLNDEPYIYFIHYLPSEMIRVRRKEFDEESLYRLL 164
Cdd:smart00866   8 TKVLS---FERVPADEELaEALGLPPGDPVY--------RIERLRLADGEPVALETTYLPAALFPGLLEEDLSGSLYEYL 76

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1352495636  165 TQKGEYIDVFSD----DFSAIFLSEKEQEILKTSA-QIGIKRIRRSSNQQGEILEYSEAIYHTDLH 225
Cdd:smart00866  77 EERLGLKIVRSTraeqTITAVLADEEEAELLGLPPgAPLLVVERVTYDDDGRPVEYSRSYYRGDRF 142
PRK11523 PRK11523
transcriptional regulator ExuR;
4-80 9.40e-12

transcriptional regulator ExuR;


Pssm-ID: 183176 [Multi-domain]  Cd Length: 253  Bit Score: 62.94  E-value: 9.40e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1352495636   4 TRILYLEVADKIKEDIFSGKYPVGTMLPTENELEELFQVSKITVRKAIELLATDEYVEKKSGRGTTVLSNRPYNRLS 80
Cdd:PRK11523    6 PRRLYQQLAAELKERIEQGVYLVGDKLPAERFIADEKNVSRTVVREAIIMLEVEGYVEVRKGSGIHVVSNQPRHQQA 82
ARO8 COG1167
DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain ...
 7-84 1.85e-11

DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain [Transcription, Amino acid transport and metabolism]; DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain is part of the Pathway/BioSystem: Lysine biosynthesis


Pssm-ID: 440781 [Multi-domain]  Cd Length: 471  Bit Score: 62.92  E-value: 1.85e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1352495636   7 LYLEVADKIKEDIFSGKYPVGTMLPTENELEELFQVSKITVRKAIELLATDEYVEKKSGRGTTVLSNRPYNRLSKAAS 84
Cdd:COG1167    13 LYLQLADALREAILSGRLPPGDRLPSSRELAAQLGVSRSTVVRAYEELEAEGLIESRPGSGTFVAARLPAPAPAPRAA 90
GntR COG1802
DNA-binding transcriptional regulator, GntR family [Transcription];
10-70 1.92e-10

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441407 [Multi-domain]  Cd Length: 222  Bit Score: 58.78  E-value: 1.92e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1352495636  10 EVADKIKEDIFSGKYPVGTMLpTENELEELFQVSKITVRKAIELLATDEYVEKKSGRGTTV 70
Cdd:COG1802    15 QVYEALREAILSGELPPGERL-SEAELAERLGVSRTPVREALRRLEAEGLVEIRPNRGARV 74
PRK10079 PRK10079
phosphonate metabolism transcriptional regulator PhnF; Provisional
 7-89 1.55e-06

phosphonate metabolism transcriptional regulator PhnF; Provisional


Pssm-ID: 182227 [Multi-domain]  Cd Length: 241  Bit Score: 47.46  E-value: 1.55e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352495636   7 LYLEVADKIKEDIfSGKYPVGTMLPTENELEELFQVSKITVRKAIELLATDEYVEKKSGRGTTVLSnRPYNR-LSKAASF 85
Cdd:PRK10079   13 RYQEIAAKLEQEL-RQHYRCGDYLPAEQQLAARYEVNRHTLRRAIDQLVEKGWVQRRQGVGVLVLM-RPYDYpLNAQARF 90


                  ....
gi 1352495636  86 TQIL 89
Cdd:PRK10079   91 SQNL 94
PRK10225 PRK10225
Uxu operon transcriptional regulator;
1-82 6.73e-06

Uxu operon transcriptional regulator;


Pssm-ID: 182318 [Multi-domain]  Cd Length: 257  Bit Score: 45.78  E-value: 6.73e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352495636   1 MKRTRIL---YLEVADKIKEDIFSGKYPVGTMLPTENELEELFQVSKITVRKAIELLATDEYVEKKSGRGTTVLSNRPYN 77
Cdd:PRK10225    1 MKSATSAqrpYQEVGAMIRDLIIKTPYNPGERLPPEREIAEMLDVTRTVVREALIMLEIKGLVEVRRGAGIYVLDSSGSH 80


                  ....*
gi 1352495636  78 RLSKA 82
Cdd:PRK10225   81 NTDSP 85
PRK03837 PRK03837
transcriptional regulator NanR; Provisional
 5-88 1.24e-05

transcriptional regulator NanR; Provisional


Pssm-ID: 235166 [Multi-domain]  Cd Length: 241  Bit Score: 45.01  E-value: 1.24e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352495636   5 RILYLEVADKIKEDIFSGKYPVGTMLPTENELEELFQVSKITVRKAIELLATDEYVEKKSGRGTTVLsnrpynRLSKAAS 84
Cdd:PRK03837   12 KKLSEEVEERLEQMIRSGEFGPGDQLPSERELMAFFGVGRPAVREALQALKRKGLVQISHGERARVS------RPSADTI 85


                  ....
gi 1352495636  85 FTQI 88
Cdd:PRK03837   86 IGQL 89
PRK04984 PRK04984
fatty acid metabolism transcriptional regulator FadR;
15-57 5.99e-04

fatty acid metabolism transcriptional regulator FadR;


Pssm-ID: 179909 [Multi-domain]  Cd Length: 239  Bit Score: 39.85  E-value: 5.99e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1352495636  15 IKEDIFSGKYPVGTMLPTENELEELFQVSKITVRKAIELLATD 57
Cdd:PRK04984   16 IIESIWNNRFPPGSILPAERELSELIGVTRTTLREVLQRLARD 58
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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