|
Name |
Accession |
Description |
Interval |
E-value |
| BaeS |
COG0642 |
Signal transduction histidine kinase [Signal transduction mechanisms]; |
144-455 |
1.23e-22 |
|
Signal transduction histidine kinase [Signal transduction mechanisms];
Pssm-ID: 440407 [Multi-domain] Cd Length: 328 Bit Score: 98.44 E-value: 1.23e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352907357 144 IQLRQNLLKQILQSVLIPLLLTLIICILLILWIIRLEFLPLDHITRHLIQKKQSLDEASRYLIELRSQKIPKEIQPFVDN 223
Cdd:COG0642 16 LLLLLALLLLLLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLL 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352907357 224 LLMLIERLHKSLEHEKNFSAFAAHELRTPLTAIKTHVQLsqLMLNQTASAQDTAKVI-DNLKHAERSIQRYQQLLEQlll 302
Cdd:COG0642 96 LLALLLLLEEANEAKSRFLANVSHELRTPLTAIRGYLEL--LLEELDEEQREYLETIlRSADRLLRLINDLLDLSRL--- 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352907357 303 lsqtEAG-IQAAHSHADMRSVLETVLSELTVEYPNLSAKLQIDWASLVAqHINIPAPALHMVLKNLIQNAYLHAEDAPNI 381
Cdd:COG0642 171 ----EAGkLELEPEPVDLAELLEEVVELFRPLAEEKGIELELDLPDDLP-TVRGDPDRLRQVLLNLLSNAIKYTPEGGTV 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352907357 382 QIYMQD----LQLIIADQGKSLNEDDFTILTQRFWR--KSAHKQGYGLGLTLVKVLLEQYGYLLQFQANQPQGLKVIVSF 455
Cdd:COG0642 246 TVSVRRegdrVRISVEDTGPGIPPEDLERIFEPFFRtdPSRRGGGTGLGLAIVKRIVELHGGTIEVESEPGKGTTFTVTL 325
|
|
| PRK10337 |
PRK10337 |
sensor protein QseC; Provisional |
180-448 |
4.65e-18 |
|
sensor protein QseC; Provisional
Pssm-ID: 182388 [Multi-domain] Cd Length: 449 Bit Score: 86.24 E-value: 4.65e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352907357 180 EFLPLDHITRHLiqKKQSLDEASryliELRSQKIPKEIQPFVDNLLMLIERLHKSLEHEKNFSAFAAHELRTPLTAIKTH 259
Cdd:PRK10337 185 ELAPLKKLALAL--RMRDPDSET----PLNATGVPSEVRPLVEALNQLFARTHAMMVRERRFTSDAAHELRSPLAALKVQ 258
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352907357 260 VQLSQLMLNQTASAQdtaKVIDNLkhaersiqryqqlleqllllsqtEAGIQAAHSHADMrsvLETvLSELTVEyPNLSA 339
Cdd:PRK10337 259 TEVAQLSDDDPQARK---KALLQL-----------------------HAGIDRATRLVDQ---LLT-LSRLDSL-DNLQD 307
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352907357 340 KLQIDWASLVAQ----------------HINIPAPA---------LHMVLKNLIQNAYLHAEDAPNIQIYMQDLQLIIAD 394
Cdd:PRK10337 308 VAEIPLEDLLQSavmdiyhtaqqagidvRLTLNAHPvirtgqpllLSLLVRNLLDNAIRYSPQGSVVDVTLNARNFTVRD 387
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*
gi 1352907357 395 QGKSLNEDDFTILTQRFWRKSA-HKQGYGLGLTLVKVLLEQYGYLLQFqANQPQG 448
Cdd:PRK10337 388 NGPGVTPEALARIGERFYRPPGqEATGSGLGLSIVRRIAKLHGMNVSF-GNAPEG 441
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
357-459 |
1.08e-12 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 64.31 E-value: 1.08e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352907357 357 APALHMVLKNLIQNAYLHAEDAPNIQIYMQ---DLQLIIADQGKSLNEDDFTILTQRFWRKSAHKQ-GYGLGLTLVKVLL 432
Cdd:pfam02518 3 ELRLRQVLSNLLDNALKHAAKAGEITVTLSeggELTLTVEDNGIGIPPEDLPRIFEPFSTADKRGGgGTGLGLSIVRKLV 82
|
90 100
....*....|....*....|....*..
gi 1352907357 433 EQYGYLLQFQANQPQGLKVIVSFDAAP 459
Cdd:pfam02518 83 ELLGGTITVESEPGGGTTVTLTLPLAQ 109
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
357-456 |
2.94e-11 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 60.36 E-value: 2.94e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352907357 357 APALHMVLKNLIQNAYLHAEDAPNIQIYM----QDLQLIIADQGKSLNEDDFTILTQRFWR---KSAHKQGYGLGLTLVK 429
Cdd:smart00387 3 PDRLRQVLSNLLDNAIKYTPEGGRITVTLerdgDHVEITVEDNGPGIPPEDLEKIFEPFFRtdkRSRKIGGTGLGLSIVK 82
|
90 100
....*....|....*....|....*..
gi 1352907357 430 VLLEQYGYLLQFQANQPQGLKVIVSFD 456
Cdd:smart00387 83 KLVELHGGEISVESEPGGGTTFTITLP 109
|
|
| HATPase_BasS-like |
cd16940 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
360-455 |
1.56e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.
Pssm-ID: 340417 [Multi-domain] Cd Length: 113 Bit Score: 55.49 E-value: 1.56e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352907357 360 LHMVLKNLIQNAYLHAEDAPNIQIYMQDL---QLIIADQGKSLNEDDFTILTQRFWR-KSAHKQGYGLGLTLVKVLLEQY 435
Cdd:cd16940 14 LFLLLRNLVDNAVRYSPQGSRVEIKLSADdgaVIRVEDNGPGIDEEELEALFERFYRsDGQNYGGSGLGLSIVKRIVELH 93
|
90 100
....*....|....*....|
gi 1352907357 436 GYLLQFQANQPQGLKVIVSF 455
Cdd:cd16940 94 GGQIFLGNAQGGGLEAWVRL 113
|
|
| cztS_silS_copS |
TIGR01386 |
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ... |
5-436 |
3.93e-09 |
|
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.
Pssm-ID: 273593 [Multi-domain] Cd Length: 457 Bit Score: 58.55 E-value: 3.93e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352907357 5 SLKWRLVSTISCAFILLWVIVFAWLYHDLEQRLQNTLDERLS-------TSARMVARLIQQLPLEQ--LTESLHAESEna 75
Cdd:TIGR01386 3 SLTLRLALLFAAVTALVFALSGFMLYSSLERHFEERDREELQgkleqvrRFLRDPADLDEDIKRLQekIDDLLVGHSD-- 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352907357 76 LLHSLIACEVSIFRADVSLPQHVIARTQGAPKNLKNQQVGFSTWTENGLQwRSYVLREGE----VQVVVAEKIQLRQNLL 151
Cdd:TIGR01386 81 LALSILNPDGRLLFERAQGAALVPAVAANDALLELDQADAKMTHYRSILR-SVAALPGGKgrkpVQITVALDINAHTHLL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352907357 152 KQILQSVLIPLLLTLIICILLILWIIRLEFLPLDHITRHLIQ-KKQSLDEasryliELRSQKIPKEIQPFVDNLLMLIER 230
Cdd:TIGR01386 160 DALRKWLILIAVLLVLLTALLGWWITRLGLEPLRRLSAVAARiSPESLDQ------RLDPSRAPAELRELAQSFNAMLGR 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352907357 231 LHKSLEHEKNFSAFAAHELRTPLTAIKTHvqlSQLMLNQTASAQDTAKVID-NLKHAERsIQRYQQLL--EQLLLLSQTE 307
Cdd:TIGR01386 234 LEDAFQRLSQFSADLAHELRTPLTNLLGQ---TQVALSQPRTGEEYREVLEsNLEELER-LSRMVSDMlfLARADNGQLA 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352907357 308 AGIQAAHSHADMRSVLEtvLSELTVEYPNLSAKLQIDwASLVAQHInipapALHMVLKNLIQNAYLHAEDAPNIQIYMQD 387
Cdd:TIGR01386 310 LERVRLDLAAELAKVAE--YFEPLAEERGVRIRVEGE-GLVRGDPQ-----MFRRAISNLLSNALRHTPDGGTITVRIER 381
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*..
gi 1352907357 388 ----LQLIIADQGKSLNEDDFTILTQRFWR----KSAHKQGYGLGLTLVKVLLEQYG 436
Cdd:TIGR01386 382 rsdeVRVSVSNPGPGIPPEHLSRLFDRFYRvdpaRSNSGEGTGLGLAIVRSIMEAHG 438
|
|
| BaeS_SmeS |
NF012163 |
sensor histidine kinase efflux regulator BaeS; |
216-455 |
1.40e-05 |
|
sensor histidine kinase efflux regulator BaeS;
Pssm-ID: 411086 [Multi-domain] Cd Length: 457 Bit Score: 47.51 E-value: 1.40e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352907357 216 EIQPFVDNLLMLIERLHKSLEHEKNFSAFAAHELRTPLTAIKthvqlSQLMLNQTASAQDTAKVIDNLKHAERSIQRyqQ 295
Cdd:NF012163 218 ELGKLAQDFNQLASTLEKNEQMRRDFMADISHELRTPLAVLR-----AELEAIQDGIRKFTPESLDSLQAEVGTLTK--L 290
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352907357 296 LLEQLLLLSQTEAGIQAAHSHADMRSVLETVLSELTVEYPNLSAKLQIDWASLVAQHINipAPALHMVLKNLIQNAYLHA 375
Cdd:NF012163 291 VDDLHDLSMSDEGALAYQKASVDLVPLLEVEGGAFRERFASAGLELEVSLPDSSLVFGD--RDRLMQLFNNLLENSLRYT 368
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352907357 376 EDAPNIQIYM----QDLQLIIADQGKSLNEDDFTILTQRFWRKSAHKQ----GYGLGLTLVKVLLEQYGYLLQFQANQPQ 447
Cdd:NF012163 369 DSGGSLHISAsqrpKEVTLTVADSAPGVSDEQLARLFERFYRVEVSRNrasgGSGLGLAISLNIVQAHGGTLHAAHSPLG 448
|
....*...
gi 1352907357 448 GLKVIVSF 455
Cdd:NF012163 449 GLRIVVTL 456
|
|
| MtrAB_MtrB |
NF040691 |
MtrAB system histidine kinase MtrB; |
247-425 |
7.36e-04 |
|
MtrAB system histidine kinase MtrB;
Pssm-ID: 468655 [Multi-domain] Cd Length: 507 Bit Score: 41.93 E-value: 7.36e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352907357 247 HELRTPLTAIKthvQLSQLMLNQTASAQDTAKVIDNLKHAErsIQRYQQLLEQLLLLSQTEAGiQAAHSH--ADMRSVLE 324
Cdd:NF040691 280 HELRTPLTTIR---MAADVIHDSRDDFDPATARSAELLHTE--LDRFESLLSDLLEISRFDAG-AAELDVepVDLRPLVR 353
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352907357 325 TVL-----------SELTVEYPNLSAKLQIDwaslvAQHINipapalhMVLKNLIQNAYLHAEDAP-NIQIYMQDLQLII 392
Cdd:NF040691 354 RVVdalrqlaeragVELRVDAPGTPVVAEVD-----PRRVE-------RVLRNLVVNAIEHGEGKPvVVTVAQDDTAVAV 421
|
170 180 190
....*....|....*....|....*....|....*....
gi 1352907357 393 A--DQGKSLNEDDFTILTQRFWR----KSAHKQGYGLGL 425
Cdd:NF040691 422 TvrDHGVGLKPGEVALVFDRFWRadpaRARTTGGTGLGL 460
|
|
| 2CSK_N |
pfam08521 |
Two-component sensor kinase N-terminal; This domain is found in bacterial two-component sensor ... |
19-154 |
2.06e-03 |
|
Two-component sensor kinase N-terminal; This domain is found in bacterial two-component sensor kinases towards the N-terminus. It recognizes Autoinducer 3 (AI-3), epinephrine, norepineprhine and Fe(III) (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 430051 Cd Length: 142 Bit Score: 38.39 E-value: 2.06e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352907357 19 ILLWVIVFAWLYHDLEQRLQNTLDERLSTSARMVARLIQ--------QLPlEQLTESLHAESEnallhSLIACEVSifra 90
Cdd:pfam08521 2 LLLWLLSAAITYRVARNAANRAYDRALLASARALAEQVRvedgelqvDLP-PAALEMLRADAE-----DRVYYQVL---- 71
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1352907357 91 dvSLPQHVIARTQGAPKNLKN-QQVGFSTWTENGLQWRSYVLR--------EGEVQVVVAEKIQLRQNLLKQI 154
Cdd:pfam08521 72 --DPDGRLLAGDADLPLPPGYaGEPRFYDAEYRGEPVRVAALArplagpgaSGPVLVQVAETLEKRDALAREI 142
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| BaeS |
COG0642 |
Signal transduction histidine kinase [Signal transduction mechanisms]; |
144-455 |
1.23e-22 |
|
Signal transduction histidine kinase [Signal transduction mechanisms];
Pssm-ID: 440407 [Multi-domain] Cd Length: 328 Bit Score: 98.44 E-value: 1.23e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352907357 144 IQLRQNLLKQILQSVLIPLLLTLIICILLILWIIRLEFLPLDHITRHLIQKKQSLDEASRYLIELRSQKIPKEIQPFVDN 223
Cdd:COG0642 16 LLLLLALLLLLLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLL 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352907357 224 LLMLIERLHKSLEHEKNFSAFAAHELRTPLTAIKTHVQLsqLMLNQTASAQDTAKVI-DNLKHAERSIQRYQQLLEQlll 302
Cdd:COG0642 96 LLALLLLLEEANEAKSRFLANVSHELRTPLTAIRGYLEL--LLEELDEEQREYLETIlRSADRLLRLINDLLDLSRL--- 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352907357 303 lsqtEAG-IQAAHSHADMRSVLETVLSELTVEYPNLSAKLQIDWASLVAqHINIPAPALHMVLKNLIQNAYLHAEDAPNI 381
Cdd:COG0642 171 ----EAGkLELEPEPVDLAELLEEVVELFRPLAEEKGIELELDLPDDLP-TVRGDPDRLRQVLLNLLSNAIKYTPEGGTV 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352907357 382 QIYMQD----LQLIIADQGKSLNEDDFTILTQRFWR--KSAHKQGYGLGLTLVKVLLEQYGYLLQFQANQPQGLKVIVSF 455
Cdd:COG0642 246 TVSVRRegdrVRISVEDTGPGIPPEDLERIFEPFFRtdPSRRGGGTGLGLAIVKRIVELHGGTIEVESEPGKGTTFTVTL 325
|
|
| KdpD |
COG2205 |
K+-sensing histidine kinase KdpD [Signal transduction mechanisms]; |
224-460 |
7.24e-22 |
|
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
Pssm-ID: 441807 [Multi-domain] Cd Length: 239 Bit Score: 94.20 E-value: 7.24e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352907357 224 LLMLIERLHKSLEHEKNFSAFAAHELRTPLTAIKTHVQLsqLMLNQTASAQDTAKVIDnlkHAERSIQRYQQLLEQLLLL 303
Cdd:COG2205 2 LEEALEELEELERLKSEFLANVSHELRTPLTSILGAAEL--LLDEEDLSPEERRELLE---IIRESAERLLRLIEDLLDL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352907357 304 SQTEAGIQAAH-SHADMRSVLETVLSELTVEYPNLSAKLQIDWASLVAqHINIPAPALHMVLKNLIQNAYLHAEDAPNIQ 382
Cdd:COG2205 77 SRLESGKLSLElEPVDLAELLEEAVEELRPLAEEKGIRLELDLPPELP-LVYADPELLEQVLANLLDNAIKYSPPGGTIT 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352907357 383 IYM----QDLQLIIADQGKSLNEDDFTILTQRFWR--KSAHKQGYGLGLTLVKVLLEQYGYLLQFQANQPQGLKVIVSFD 456
Cdd:COG2205 156 ISArregDGVRISVSDNGPGIPEEELERIFERFYRgdNSRGEGGTGLGLAIVKRIVEAHGGTIWVESEPGGGTTFTVTLP 235
|
....
gi 1352907357 457 AAPS 460
Cdd:COG2205 236 LAES 239
|
|
| PRK10337 |
PRK10337 |
sensor protein QseC; Provisional |
180-448 |
4.65e-18 |
|
sensor protein QseC; Provisional
Pssm-ID: 182388 [Multi-domain] Cd Length: 449 Bit Score: 86.24 E-value: 4.65e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352907357 180 EFLPLDHITRHLiqKKQSLDEASryliELRSQKIPKEIQPFVDNLLMLIERLHKSLEHEKNFSAFAAHELRTPLTAIKTH 259
Cdd:PRK10337 185 ELAPLKKLALAL--RMRDPDSET----PLNATGVPSEVRPLVEALNQLFARTHAMMVRERRFTSDAAHELRSPLAALKVQ 258
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352907357 260 VQLSQLMLNQTASAQdtaKVIDNLkhaersiqryqqlleqllllsqtEAGIQAAHSHADMrsvLETvLSELTVEyPNLSA 339
Cdd:PRK10337 259 TEVAQLSDDDPQARK---KALLQL-----------------------HAGIDRATRLVDQ---LLT-LSRLDSL-DNLQD 307
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352907357 340 KLQIDWASLVAQ----------------HINIPAPA---------LHMVLKNLIQNAYLHAEDAPNIQIYMQDLQLIIAD 394
Cdd:PRK10337 308 VAEIPLEDLLQSavmdiyhtaqqagidvRLTLNAHPvirtgqpllLSLLVRNLLDNAIRYSPQGSVVDVTLNARNFTVRD 387
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*
gi 1352907357 395 QGKSLNEDDFTILTQRFWRKSA-HKQGYGLGLTLVKVLLEQYGYLLQFqANQPQG 448
Cdd:PRK10337 388 NGPGVTPEALARIGERFYRPPGqEATGSGLGLSIVRRIAKLHGMNVSF-GNAPEG 441
|
|
| WalK |
COG5002 |
Sensor histidine kinase WalK [Signal transduction mechanisms]; |
124-460 |
5.63e-16 |
|
Sensor histidine kinase WalK [Signal transduction mechanisms];
Pssm-ID: 444026 [Multi-domain] Cd Length: 390 Bit Score: 79.60 E-value: 5.63e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352907357 124 LQWRSYVLREGEVQVVVAEKIQLRQNLLKQILQSVLIPLLLTLIICILLILWIIRLEFLPLDHITRHLIQKKQSLDEASR 203
Cdd:COG5002 47 LLLLLLALLLLLLLLLLLLLALLLLLLLLLLLLALALLLLALLLLLLLLLLLLALLILLLLLALLILLAALLLLLSELLL 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352907357 204 YLIELRSQKIPKEIQPFVDNLLML----IERLHKSLEHEKNFSAFAAHELRTPLTAIKTHVQLsqLMLNQTASAQDTAKV 279
Cdd:COG5002 127 LLLLLGRLSLRLSALLLGLLLLAAverdITELERLEQMRREFVANVSHELRTPLTSIRGYLEL--LLDGAADDPEERREY 204
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352907357 280 IDN-LKHAER---------SIQRYqqlleqllllsqtEAG-IQAAHSHADMRSVLETVLSELTVEYPNLSAKLQIDwasL 348
Cdd:COG5002 205 LEIiLEEAERlsrlvndllDLSRL-------------ESGeLKLEKEPVDLAELLEEVVEELRPLAEEKGIELELD---L 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352907357 349 VAQHINIPA--PALHMVLKNLIQNAYLHAEDAPNIQIYMQD----LQLIIADQGKSLNEDDFTILTQRFWR----KSAHK 418
Cdd:COG5002 269 PEDPLLVLGdpDRLEQVLTNLLDNAIKYTPEGGTITVSLREeddqVRISVRDTGIGIPEEDLPRIFERFYRvdksRSRET 348
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 1352907357 419 QGYGLGLTLVKVLLEQYGYLLQFQANQPQGLKVIVSFDAAPS 460
Cdd:COG5002 349 GGTGLGLAIVKHIVEAHGGRIWVESEPGKGTTFTITLPLARE 390
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
357-459 |
1.08e-12 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 64.31 E-value: 1.08e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352907357 357 APALHMVLKNLIQNAYLHAEDAPNIQIYMQ---DLQLIIADQGKSLNEDDFTILTQRFWRKSAHKQ-GYGLGLTLVKVLL 432
Cdd:pfam02518 3 ELRLRQVLSNLLDNALKHAAKAGEITVTLSeggELTLTVEDNGIGIPPEDLPRIFEPFSTADKRGGgGTGLGLSIVRKLV 82
|
90 100
....*....|....*....|....*..
gi 1352907357 433 EQYGYLLQFQANQPQGLKVIVSFDAAP 459
Cdd:pfam02518 83 ELLGGTITVESEPGGGTTVTLTLPLAQ 109
|
|
| PRK10755 |
PRK10755 |
two-component system sensor histidine kinase PmrB; |
187-428 |
1.41e-12 |
|
two-component system sensor histidine kinase PmrB;
Pssm-ID: 236751 [Multi-domain] Cd Length: 356 Bit Score: 68.84 E-value: 1.41e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352907357 187 ITRHLIQKKQSLDEAS-RYLIELRSQKIPKEIQPFVDNLLMLIERLHKSLEHEKNFSAFAAHELRTPLTAIKTHvqlsqL 265
Cdd:PRK10755 85 ITRPLAELQKELEARTaDNLTPIAIHSSTLEIEAVTSALNQLVSRLTSTLDQERLFTADVAHELRTPLAGIRLH-----L 159
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352907357 266 MLNQTASAQDTAKVIDNLKHAERSIQRyqqlleqllLLSQTEAGIQAAHSHADMRSVLETVLSELTVEYPNLSAKLQ--I 343
Cdd:PRK10755 160 ELLEKQHHIDVAPLIARLDQMMHTVEQ---------LLQLARAGQSFSSGHYQTVKLLEDVILPSQDELSEMLEQRQqtL 230
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352907357 344 DWaSLVAQHINIPAPA--LHMVLKNLIQNAYLHAEDAPNIQIYM----QDLQLIIADQGKSLNEDDFTILTQRFWRKSAH 417
Cdd:PRK10755 231 LL-PESAADITVQGDAtlLRLLLRNLVENAHRYSPEGSTITIKLsqedGGAVLAVEDEGPGIDESKCGELSKAFVRMDSR 309
|
250
....*....|.
gi 1352907357 418 KQGYGLGLTLV 428
Cdd:PRK10755 310 YGGIGLGLSIV 320
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
357-456 |
2.94e-11 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 60.36 E-value: 2.94e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352907357 357 APALHMVLKNLIQNAYLHAEDAPNIQIYM----QDLQLIIADQGKSLNEDDFTILTQRFWR---KSAHKQGYGLGLTLVK 429
Cdd:smart00387 3 PDRLRQVLSNLLDNAIKYTPEGGRITVTLerdgDHVEITVEDNGPGIPPEDLEKIFEPFFRtdkRSRKIGGTGLGLSIVK 82
|
90 100
....*....|....*....|....*..
gi 1352907357 430 VLLEQYGYLLQFQANQPQGLKVIVSFD 456
Cdd:smart00387 83 KLVELHGGEISVESEPGGGTTFTITLP 109
|
|
| HATPase_BasS-like |
cd16940 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
360-455 |
1.56e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.
Pssm-ID: 340417 [Multi-domain] Cd Length: 113 Bit Score: 55.49 E-value: 1.56e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352907357 360 LHMVLKNLIQNAYLHAEDAPNIQIYMQDL---QLIIADQGKSLNEDDFTILTQRFWR-KSAHKQGYGLGLTLVKVLLEQY 435
Cdd:cd16940 14 LFLLLRNLVDNAVRYSPQGSRVEIKLSADdgaVIRVEDNGPGIDEEELEALFERFYRsDGQNYGGSGLGLSIVKRIVELH 93
|
90 100
....*....|....*....|
gi 1352907357 436 GYLLQFQANQPQGLKVIVSF 455
Cdd:cd16940 94 GGQIFLGNAQGGGLEAWVRL 113
|
|
| cztS_silS_copS |
TIGR01386 |
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ... |
5-436 |
3.93e-09 |
|
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.
Pssm-ID: 273593 [Multi-domain] Cd Length: 457 Bit Score: 58.55 E-value: 3.93e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352907357 5 SLKWRLVSTISCAFILLWVIVFAWLYHDLEQRLQNTLDERLS-------TSARMVARLIQQLPLEQ--LTESLHAESEna 75
Cdd:TIGR01386 3 SLTLRLALLFAAVTALVFALSGFMLYSSLERHFEERDREELQgkleqvrRFLRDPADLDEDIKRLQekIDDLLVGHSD-- 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352907357 76 LLHSLIACEVSIFRADVSLPQHVIARTQGAPKNLKNQQVGFSTWTENGLQwRSYVLREGE----VQVVVAEKIQLRQNLL 151
Cdd:TIGR01386 81 LALSILNPDGRLLFERAQGAALVPAVAANDALLELDQADAKMTHYRSILR-SVAALPGGKgrkpVQITVALDINAHTHLL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352907357 152 KQILQSVLIPLLLTLIICILLILWIIRLEFLPLDHITRHLIQ-KKQSLDEasryliELRSQKIPKEIQPFVDNLLMLIER 230
Cdd:TIGR01386 160 DALRKWLILIAVLLVLLTALLGWWITRLGLEPLRRLSAVAARiSPESLDQ------RLDPSRAPAELRELAQSFNAMLGR 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352907357 231 LHKSLEHEKNFSAFAAHELRTPLTAIKTHvqlSQLMLNQTASAQDTAKVID-NLKHAERsIQRYQQLL--EQLLLLSQTE 307
Cdd:TIGR01386 234 LEDAFQRLSQFSADLAHELRTPLTNLLGQ---TQVALSQPRTGEEYREVLEsNLEELER-LSRMVSDMlfLARADNGQLA 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352907357 308 AGIQAAHSHADMRSVLEtvLSELTVEYPNLSAKLQIDwASLVAQHInipapALHMVLKNLIQNAYLHAEDAPNIQIYMQD 387
Cdd:TIGR01386 310 LERVRLDLAAELAKVAE--YFEPLAEERGVRIRVEGE-GLVRGDPQ-----MFRRAISNLLSNALRHTPDGGTITVRIER 381
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*..
gi 1352907357 388 ----LQLIIADQGKSLNEDDFTILTQRFWR----KSAHKQGYGLGLTLVKVLLEQYG 436
Cdd:TIGR01386 382 rsdeVRVSVSNPGPGIPPEHLSRLFDRFYRvdpaRSNSGEGTGLGLAIVRSIMEAHG 438
|
|
| NtrY |
COG5000 |
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ... |
246-461 |
4.57e-09 |
|
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];
Pssm-ID: 444024 [Multi-domain] Cd Length: 422 Bit Score: 58.05 E-value: 4.57e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352907357 246 AHELRTPLTAIKTHVQ-LSQLMLNQTASAQD-----TAKVIDNLKHAERSIQRYQQLleqllllsqteAGIQAAH-SHAD 318
Cdd:COG5000 209 AHEIKNPLTPIQLSAErLRRKLADKLEEDREdleraLDTIIRQVDRLKRIVDEFLDF-----------ARLPEPQlEPVD 277
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352907357 319 MRSVLETVLSELTVEYPNLSAKLQIDWASlVAQHINIPAPALHMVLKNLIQNAYLHAEDAPNIQIYMQ----DLQLIIAD 394
Cdd:COG5000 278 LNELLREVLALYEPALKEKDIRLELDLDP-DLPEVLADRDQLEQVLINLLKNAIEAIEEGGEIEVSTRredgRVRIEVSD 356
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1352907357 395 QGKSLNEDDFTILTQRFWrkSAHKQGYGLGLTLVKVLLEQYGYLLQFQANQPQGLKVIVSFDAAPSA 461
Cdd:COG5000 357 NGPGIPEEVLERIFEPFF--TTKPKGTGLGLAIVKKIVEEHGGTIELESRPGGGTTFTIRLPLAEEA 421
|
|
| COG4191 |
COG4191 |
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ... |
246-455 |
6.42e-08 |
|
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];
Pssm-ID: 443345 [Multi-domain] Cd Length: 361 Bit Score: 54.42 E-value: 6.42e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352907357 246 AHELRTPLTAIKTHVQLSQLMLNQTASAQDTAKVIDN-LKHAER------SIQRYqqlleqllllsqteAGIQAAHSHA- 317
Cdd:COG4191 150 AHEINNPLAAILGNAELLRRRLEDEPDPEELREALERiLEGAERaaeivrSLRAF--------------SRRDEEEREPv 215
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352907357 318 DMRSVLETVLSELTVEYPNLSAKLQIDWASLVAQhINIPAPALHMVLKNLIQNAyLHA-EDAPN----IQIYMQD--LQL 390
Cdd:COG4191 216 DLNELIDEALELLRPRLKARGIEVELDLPPDLPP-VLGDPGQLEQVLLNLLINA-IDAmEEGEGgritISTRREGdyVVI 293
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1352907357 391 IIADQGKSLNEDD--------FTilTqrfwrKSAHKqGYGLGLTLVKVLLEQYGYLLQFQANQPQGLKVIVSF 455
Cdd:COG4191 294 SVRDNGPGIPPEVlerifepfFT--T-----KPVGK-GTGLGLSISYGIVEKHGGRIEVESEPGGGTTFTITL 358
|
|
| KinD |
COG5808 |
Sporulation sensor histidine kinase D [Cell cycle control, cell division, chromosome ... |
241-455 |
8.60e-08 |
|
Sporulation sensor histidine kinase D [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444510 [Multi-domain] Cd Length: 454 Bit Score: 54.37 E-value: 8.60e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352907357 241 FSAFAAHELRTPLTAIKTHVQLSQlMLNQTASAQDTAKVIDN-LKHAERSIQRYQQLLEQLLLLSQTEagiqaahshaDM 319
Cdd:COG5808 244 FAASTAHEIRNPLTSIKGFIQLLQ-EKYPELEDQKYFDIIQEeIQRINQIVSEFLVLGKPTAKKLELD----------DL 312
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352907357 320 RSVLETVLSelTVEYPNLSAKLQIDWASL-VAQHINIPAPALHMVLKNLIQNA--YLHAEDAPNIQIYMQD--LQLIIAD 394
Cdd:COG5808 313 NELIEEILS--IIDSEANLKNIRVEKQSLdEPLHIKCDKDRIKQVLLNLIKNAieAMKEGGKLTISIENDDekAVIEVID 390
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1352907357 395 QGKSLNEDDFTILTQRFWRKSahKQGYGLGLTLVKVLLEQYGYLLQFQANQPQGLKVIVSF 455
Cdd:COG5808 391 NGEGIPEDIIDEIFEPFVTTK--EGGTGLGLSVCKRIVEMHGGEIDIESEEGKGTTFTIRL 449
|
|
| HATPase_SpaK_NisK-like |
cd16975 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
359-455 |
9.12e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.
Pssm-ID: 340434 [Multi-domain] Cd Length: 107 Bit Score: 50.15 E-value: 9.12e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352907357 359 ALHMVLKNLIQNAYLHAEDAPNIQIYMQD----LQLIIADQGKSLNEDDFTILTQRFWR--KSAHKQG-YGLGLTLVKVL 431
Cdd:cd16975 4 LLSRALINIISNACQYAPEGGTVSISIYDeeeyLYFEIWDNGHGFSEQDLKKALELFYRddTSRRSGGhYGMGLYIAKNL 83
|
90 100
....*....|....*....|....
gi 1352907357 432 LEQYGYLLQFQANQPQGLKVIVSF 455
Cdd:cd16975 84 VEKHGGSLIIENSQKGGAEVTVKI 107
|
|
| HATPase_CpxA-like |
cd16949 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
360-451 |
8.68e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.
Pssm-ID: 340425 [Multi-domain] Cd Length: 104 Bit Score: 47.32 E-value: 8.68e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352907357 360 LHMVLKNLIQNAYLHAEDAPNIQIYMQD--LQLIIADQGKSLNEDDFTILTQRFWR----KSAHKQGYGLGLTLVKVLLE 433
Cdd:cd16949 1 LARALENVLRNALRYSPSKILLDISQDGdqWTITITDDGPGVPEDQLEQIFLPFYRvdsaRDRESGGTGLGLAIAERAIE 80
|
90
....*....|....*...
gi 1352907357 434 QYGYLLQFQANQPQGLKV 451
Cdd:cd16949 81 QHGGKIKASNRKPGGLRV 98
|
|
| KinC |
COG5807 |
Sporulation sensor histidine kinase C [Cell cycle control, cell division, chromosome ... |
246-455 |
1.17e-06 |
|
Sporulation sensor histidine kinase C [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444509 [Multi-domain] Cd Length: 358 Bit Score: 50.55 E-value: 1.17e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352907357 246 AHELRTPLTAIKTHVQLsqlmLNQTASAQDTAK----VIDNLKHAERSIQRYQQLLEQLLLLsqteagiqaaHSHADMRS 321
Cdd:COG5807 155 AHEIRNPLTSIKGFLQL----LQESREDSEREEyfniIISEIDRINTIITELLVLSKPKKFN----------FKKLNLND 220
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352907357 322 VLETVLSELTVEYPNLSAKLQIDWASLVAqHINIPAPALHMVLKNLIQNAYLHAEDAPNIQI--YMQD--LQLIIADQGK 397
Cdd:COG5807 221 VLEDVIALLSTEAILKNISIKYDLADDEP-VINGDKNQLKQVFINLIKNAIEAMETGGNITIktYVEGdfVVISVKDEGI 299
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 1352907357 398 SLNEDDFTILTQRFWrkSAHKQGYGLGLTLVKVLLEQYGYLLQFQANQPQGLKVIVSF 455
Cdd:COG5807 300 GIPEEVLEKIGEPFF--TTKEEGTGLGLSICKKIIEEHNGTIEVESKPGKGTTFTIYL 355
|
|
| HATPase_YcbM-like |
cd16947 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
352-436 |
3.14e-06 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).
Pssm-ID: 340423 [Multi-domain] Cd Length: 125 Bit Score: 46.35 E-value: 3.14e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352907357 352 HINIP---------APALHMVLKNLIQNAYLHAEDAPNIQIYMQDLQ----LIIADQGKSLNEDDFTILTQRFW-----R 413
Cdd:cd16947 4 EINIPdrpiyananTEALQRILKNLISNAIKYGSDGKFLGMTLREDEkhvyIDIWDKGKGISETEKDHVFERLYtledsR 83
|
90 100
....*....|....*....|...
gi 1352907357 414 KSAhKQGYGLGLTLVKVLLEQYG 436
Cdd:cd16947 84 NSA-KQGNGLGLTITKRLAESMG 105
|
|
| HATPase_PhoQ-like |
cd16954 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
363-455 |
3.22e-06 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.
Pssm-ID: 340430 [Multi-domain] Cd Length: 135 Bit Score: 46.47 E-value: 3.22e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352907357 363 VLKNLIQNAYLHAEDAPNIQIYMQD--LQLIIADQGKSLNEDDFTILTQRFWRKSAHKQGYGLGLTLVKVLLEQYGYLLQ 440
Cdd:cd16954 41 LLGNLLDNACKWCLEFVEVTARQTDggLHLIVDDDGPGVPESQRSKIFQRGQRLDEQRPGQGLGLAIAKEIVEQYGGELS 120
|
90
....*....|....*
gi 1352907357 441 FQANQPQGLKVIVSF 455
Cdd:cd16954 121 LSDSPLGGARFEVVF 135
|
|
| phoR_proteo |
TIGR02966 |
phosphate regulon sensor kinase PhoR; Members of this protein family are the regulatory ... |
217-436 |
1.00e-05 |
|
phosphate regulon sensor kinase PhoR; Members of this protein family are the regulatory histidine kinase PhoR associated with the phosphate ABC transporter in most Proteobacteria. Related proteins from Gram-positive organisms are not included in this model. The phoR gene usually is adjacent to the response regulator phoB gene (TIGR02154). [Signal transduction, Two-component systems]
Pssm-ID: 274368 [Multi-domain] Cd Length: 333 Bit Score: 47.59 E-value: 1.00e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352907357 217 IQPFVDNLLML----IERLHKSLEHEKNFSAFAAHELRTPLTAIKTHVQlsqlMLNQTASAQDtakvidnlKHAERSI-- 290
Cdd:TIGR02966 89 IAPYGEEQKLLvardVTRLRRLEQMRRDFVANVSHELRTPLTVLRGYLE----TLADGPDEDP--------EEWNRALei 156
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352907357 291 -----QRYQQLLEQLLLLSQTE-AGIQAAHSHADMRSVLETVLSELTVeypnLSAKLQidwaslVAQHINIPAPA----- 359
Cdd:TIGR02966 157 mleqsQRMQSLVEDLLTLSRLEsAASPLEDEPVDMPALLDHLRDEAEA----LSQGKN------HQITFEIDGGVdvlgd 226
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352907357 360 ---LHMVLKNLIQNAYLHAEDAPNIQIYMQ----DLQLIIADQGKSLNEDDFTILTQRFWR----KSAHKQGYGLGLTLV 428
Cdd:TIGR02966 227 edeLRSAFSNLVSNAIKYTPEGGTITVRWRrdggGAEFSVTDTGIGIAPEHLPRLTERFYRvdksRSRDTGGTGLGLAIV 306
|
....*...
gi 1352907357 429 KVLLEQYG 436
Cdd:TIGR02966 307 KHVLSRHH 314
|
|
| CitA |
COG3290 |
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ... |
340-455 |
1.09e-05 |
|
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];
Pssm-ID: 442519 [Multi-domain] Cd Length: 389 Bit Score: 47.54 E-value: 1.09e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352907357 340 KLQIDWASLVAqHINIPAPALHMVLKNLIQNAYLHAEDAPN----IQIYMQD----LQLIIADQGKSLNEDDFT-ILTQR 410
Cdd:COG3290 263 DLTIDIDSDLP-DLPLSDTDLVTILGNLLDNAIEAVEKLPEeerrVELSIRDdgdeLVIEVEDSGPGIPEELLEkIFERG 341
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 1352907357 411 FWRKSAHkqGYGLGLTLVKVLLEQYGYLLQFQANQPQGLKVIVSF 455
Cdd:COG3290 342 FSTKLGE--GRGLGLALVKQIVEKYGGTIEVESEEGEGTVFTVRL 384
|
|
| PRK09835 |
PRK09835 |
Cu(+)/Ag(+) sensor histidine kinase; |
182-433 |
1.28e-05 |
|
Cu(+)/Ag(+) sensor histidine kinase;
Pssm-ID: 182101 [Multi-domain] Cd Length: 482 Bit Score: 47.46 E-value: 1.28e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352907357 182 LPLDHITRHlIQKKQSLDEASRylieLRSQKIPKEIQPFVDNLLMLIERLHKSLEHEKNFSAFAAHELRTPLTAIKTHvq 261
Cdd:PRK09835 211 APIRSVSRQ-IQNITSKDLDVR----LDPQTVPIELEQLVLSFNHMIERIEDVFTRQSNFSADIAHEIRTPITNLITQ-- 283
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352907357 262 lSQLMLNQTASAQDTAKVI-DNLKHAERsiqryqqlleqllllsqteagiqAAHSHADM---------RSVLETVLSELT 331
Cdd:PRK09835 284 -TEIALSQSRSQKELEDVLySNLEELTR-----------------------MAKMVSDMlflaqadnnQLIPEKKMLDLA 339
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352907357 332 VEYPNLSAKLQIdWAS--LVAQHINIPAPA-------LHMVLKNLIQNAYLHAEDAPNIQIYMQD----LQLIIADQGKS 398
Cdd:PRK09835 340 DEVGKVFDFFEA-WAEerGVELRFVGDPCQvagdplmLRRAISNLLSNALRYTPAGEAITVRCQEvdhqVQLVVENPGTP 418
|
250 260 270
....*....|....*....|....*....|....*....
gi 1352907357 399 LNEDDFTILTQRFWRKSAHKQ----GYGLGLTLVKVLLE 433
Cdd:PRK09835 419 IAPEHLPRLFDRFYRVDPSRQrkgeGSGIGLAIVKSIVV 457
|
|
| BaeS_SmeS |
NF012163 |
sensor histidine kinase efflux regulator BaeS; |
216-455 |
1.40e-05 |
|
sensor histidine kinase efflux regulator BaeS;
Pssm-ID: 411086 [Multi-domain] Cd Length: 457 Bit Score: 47.51 E-value: 1.40e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352907357 216 EIQPFVDNLLMLIERLHKSLEHEKNFSAFAAHELRTPLTAIKthvqlSQLMLNQTASAQDTAKVIDNLKHAERSIQRyqQ 295
Cdd:NF012163 218 ELGKLAQDFNQLASTLEKNEQMRRDFMADISHELRTPLAVLR-----AELEAIQDGIRKFTPESLDSLQAEVGTLTK--L 290
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352907357 296 LLEQLLLLSQTEAGIQAAHSHADMRSVLETVLSELTVEYPNLSAKLQIDWASLVAQHINipAPALHMVLKNLIQNAYLHA 375
Cdd:NF012163 291 VDDLHDLSMSDEGALAYQKASVDLVPLLEVEGGAFRERFASAGLELEVSLPDSSLVFGD--RDRLMQLFNNLLENSLRYT 368
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352907357 376 EDAPNIQIYM----QDLQLIIADQGKSLNEDDFTILTQRFWRKSAHKQ----GYGLGLTLVKVLLEQYGYLLQFQANQPQ 447
Cdd:NF012163 369 DSGGSLHISAsqrpKEVTLTVADSAPGVSDEQLARLFERFYRVEVSRNrasgGSGLGLAISLNIVQAHGGTLHAAHSPLG 448
|
....*...
gi 1352907357 448 GLKVIVSF 455
Cdd:NF012163 449 GLRIVVTL 456
|
|
| HisKA |
cd00082 |
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ... |
235-282 |
4.00e-05 |
|
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.
Pssm-ID: 119399 [Multi-domain] Cd Length: 65 Bit Score: 41.43 E-value: 4.00e-05
10 20 30 40
....*....|....*....|....*....|....*....|....*...
gi 1352907357 235 LEHEKNFSAFAAHELRTPLTAIKTHVQLSQLMLNQTASAQDTAKVIDN 282
Cdd:cd00082 1 LQAKGEFLANVSHELRTPLTAIRGALELLEEELLDDEEQREYLERIRE 48
|
|
| HATPase_BaeS-like |
cd16946 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
360-455 |
6.80e-05 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.
Pssm-ID: 340422 [Multi-domain] Cd Length: 109 Bit Score: 42.06 E-value: 6.80e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352907357 360 LHMVLKNLIQNAYLHAEDAPNIQIYM----QDLQLIIADQGKSLNEDDFTILTQRFWRKSAHKQ----GYGLGLTLVKVL 431
Cdd:cd16946 5 LQQLFVNLLENSLRYTDTGGKLRIRAaqtpQEVRLDVEDSAPGVSDDQLARLFERFYRVESSRNrasgGSGLGLAICHNI 84
|
90 100
....*....|....*....|....
gi 1352907357 432 LEQYGYLLQFQANQPQGLKVIVSF 455
Cdd:cd16946 85 ALAHGGTISAEHSPLGGLRLVLTL 108
|
|
| HATPase_DpiB-CitA-like |
cd16915 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
363-436 |
2.22e-04 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.
Pssm-ID: 340392 [Multi-domain] Cd Length: 104 Bit Score: 40.35 E-value: 2.22e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352907357 363 VLKNLIQNAY--LHAEDAPNIQIYM------QDLQLIIADQGKSLNEDDFTILTQRFWRKSAHKqGYGLGLTLVKVLLEQ 434
Cdd:cd16915 4 IVGNLIDNALdaLAATGAPNKQVEVflrdegDDLVIEVRDTGPGIAPELRDKVFERGVSTKGQG-ERGIGLALVRQSVER 82
|
..
gi 1352907357 435 YG 436
Cdd:cd16915 83 LG 84
|
|
| NtrB |
COG3852 |
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms]; |
246-464 |
2.34e-04 |
|
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
Pssm-ID: 443061 [Multi-domain] Cd Length: 361 Bit Score: 43.30 E-value: 2.34e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352907357 246 AHELRTPLTAIKTHVQLSQLMLNQTASAQDTAKVIDNLKHAERSIQRYQQLLEQLlllsqteagiQAAHSHADMRSVLET 325
Cdd:COG3852 143 AHEIRNPLTGIRGAAQLLERELPDDELREYTQLIIEEADRLNNLVDRLLSFSRPR----------PPEREPVNLHEVLER 212
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352907357 326 VLSELTVEYP-NLSAKLQIDwASLVAqhINIPAPALHMVLKNLIQNAY----------LHAEDAPNIQIYMQD----LQL 390
Cdd:COG3852 213 VLELLRAEAPkNIRIVRDYD-PSLPE--VLGDPDQLIQVLLNLVRNAAeampeggtitIRTRVERQVTLGGLRprlyVRI 289
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1352907357 391 IIADQGKSLNEDDF-TILTQRFwrkSAHKQGYGLGLTLVKVLLEQYGYLLQFQANQPQGLKVIVSFDAAPSATEK 464
Cdd:COG3852 290 EVIDNGPGIPEEILdRIFEPFF---TTKEKGTGLGLAIVQKIVEQHGGTIEVESEPGKGTTFRIYLPLEQAEEEP 361
|
|
| PRK09303 |
PRK09303 |
histidine kinase; |
229-427 |
2.43e-04 |
|
histidine kinase;
Pssm-ID: 236462 [Multi-domain] Cd Length: 380 Bit Score: 43.40 E-value: 2.43e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352907357 229 ERLHKSLEHEKNFSAFAAHELRTPLTAIKTHVQLSQLMLNQT---ASAQDTAKVIDNLKHAERSIQRYQQLLEQLLLLSQ 305
Cdd:PRK09303 142 ETLLEQLKFKDRVLAMLAHDLRTPLTAASLALETLELGQIDEdteLKPALIEQLQDQARRQLEEIERLITDLLEVGRTRW 221
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352907357 306 TEAGIQAahSHADMRSVLETVLSELTVEYPNLSAKLQIDwaslvaqhinIPA--PALH-------MVLKNLIQNAYLHAE 376
Cdd:PRK09303 222 EALRFNP--QKLDLGSLCQEVILELEKRWLAKSLEIQTD----------IPSdlPSVYadqerirQVLLNLLDNAIKYTP 289
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 1352907357 377 DAPNIQIYM-----QDLQLIIADQGKSL-NEDDFTILTQRF-WRKSAHKQGYGLGLTL 427
Cdd:PRK09303 290 EGGTITLSMlhrttQKVQVSICDTGPGIpEEEQERIFEDRVrLPRDEGTEGYGIGLSV 347
|
|
| marine_sort_HK |
TIGR03785 |
proteobacterial dedicated sortase system histidine kinase; This histidine kinase protein is ... |
187-453 |
4.33e-04 |
|
proteobacterial dedicated sortase system histidine kinase; This histidine kinase protein is paired with an adjacent response regulator (TIGR03787) gene. It co-occurs with a variant sortase enzyme (TIGR03784), usually in the same gene neighborhood, in proteobacterial species most of which are marine, and with an LPXTG motif-containing sortase target conserved protein (TIGR03788). Sortases and LPXTG proteins are far more common in Gram-positive bacteria, where sortase systems mediate attachment to the cell wall or cross-linking of pilin structures. We give this predicted sensor histidine kinase the gene symbol psdS, for Proteobacterial Dedicated Sortase system Sensor histidine kinase.
Pssm-ID: 163497 [Multi-domain] Cd Length: 703 Bit Score: 42.81 E-value: 4.33e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352907357 187 ITRHLIQKKQSLDEASRYLIELRSQKIPKEIQPFVDNLLMLIERLHKSLEHEKNFSAFAAHELRTPLTAIKTHVQLsqlm 266
Cdd:TIGR03785 434 IRRLSDDAEAAIDSQGRISGAIPASRSRDEIGDLSRSFAQMVARLRQYTHYLENMSSRLSHELRTPVAVVRSSLEN---- 509
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352907357 267 LNQTASAQDTAKVIDnlkHAERSIQRYQQLLEQLLLLSQTEAGIQAAHSHA-DMRSVLETVLSELTVEYPNLSAKLQIDW 345
Cdd:TIGR03785 510 LELQALEQEKQKYLE---RAREGTERLSMILNNMSEATRLEQAIQSAEVEDfDLSEVLSGCMQGYQMTYPPQRFELNIPE 586
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352907357 346 ASLVAQhinIPAPALHMVLKNLIQNA--YLHAEDAPNIQIYMQDLQ--LIIADQGKSLNEDD----FT-ILTQRfwRKSA 416
Cdd:TIGR03785 587 TPLVMR---GSPELIAQMLDKLVDNAreFSPEDGLIEVGLSQNKSHalLTVSNEGPPLPEDMgeqlFDsMVSVR--DQGA 661
|
250 260 270
....*....|....*....|....*....|....*...
gi 1352907357 417 HKQGY-GLGLTLVKVLLEQYGYLLQFQaNQPQGLKVIV 453
Cdd:TIGR03785 662 QDQPHlGLGLYIVRLIADFHQGRIQAE-NRQQNDGVVF 698
|
|
| HATPase_BceS-YxdK-YvcQ-like |
cd16948 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
360-455 |
5.00e-04 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.
Pssm-ID: 340424 [Multi-domain] Cd Length: 109 Bit Score: 39.58 E-value: 5.00e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352907357 360 LHMVLKNLIQNAYLHAEDAPNIQIYMQD----LQLIIADQGKSLNEDD--------FTILTQRFWRKSAhkqgyGLGLTL 427
Cdd:cd16948 6 LSFIIGQIVSNALKYSKQGGKIEIYSETneqgVVLSIKDFGIGIPEEDlprvfdkgFTGENGRNFQEST-----GMGLYL 80
|
90 100
....*....|....*....|....*...
gi 1352907357 428 VKVLLEQYGYLLQFQANQPQGLKVIVSF 455
Cdd:cd16948 81 VKKLCDKLGHKIDVESEVGEGTTFTITF 108
|
|
| COG3920 |
COG3920 |
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ... |
315-462 |
5.33e-04 |
|
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];
Pssm-ID: 443125 [Multi-domain] Cd Length: 495 Bit Score: 42.20 E-value: 5.33e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352907357 315 SHADMRSVLETVLSELTVEYPNLSAKLQIDwaslvAQHINIP---APALHMVLKNLIQNAYLHA---EDAPNIQIYMQ-- 386
Cdd:COG3920 357 EGVDLRDYLRELLEPLRDSYGGRGIRIELD-----GPDVELPadaAVPLGLILNELVTNALKHAflsGEGGRIRVSWRre 431
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1352907357 387 --DLQLIIADQGKSLNEDdFTILTQRfwrksahkqgyGLGLTLVKVLLEQYGYllQFQANQPQGLKVIVSFDAAPSAT 462
Cdd:COG3920 432 dgRLRLTVSDNGVGLPED-VDPPARK-----------GLGLRLIRALVRQLGG--TLELDRPEGTRVRITFPLAELAA 495
|
|
| HisKA |
pfam00512 |
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ... |
240-292 |
6.96e-04 |
|
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.
Pssm-ID: 459839 [Multi-domain] Cd Length: 66 Bit Score: 37.96 E-value: 6.96e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 1352907357 240 NFSAFAAHELRTPLTAIKTHVQlsqlMLNQTASAQDTAKVIDNLKHAERSIQR 292
Cdd:pfam00512 4 EFLANLSHELRTPLTAIRGYLE----LLRDEKLDEEQREYLETILRSAERLLR 52
|
|
| MtrAB_MtrB |
NF040691 |
MtrAB system histidine kinase MtrB; |
247-425 |
7.36e-04 |
|
MtrAB system histidine kinase MtrB;
Pssm-ID: 468655 [Multi-domain] Cd Length: 507 Bit Score: 41.93 E-value: 7.36e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352907357 247 HELRTPLTAIKthvQLSQLMLNQTASAQDTAKVIDNLKHAErsIQRYQQLLEQLLLLSQTEAGiQAAHSH--ADMRSVLE 324
Cdd:NF040691 280 HELRTPLTTIR---MAADVIHDSRDDFDPATARSAELLHTE--LDRFESLLSDLLEISRFDAG-AAELDVepVDLRPLVR 353
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352907357 325 TVL-----------SELTVEYPNLSAKLQIDwaslvAQHINipapalhMVLKNLIQNAYLHAEDAP-NIQIYMQDLQLII 392
Cdd:NF040691 354 RVVdalrqlaeragVELRVDAPGTPVVAEVD-----PRRVE-------RVLRNLVVNAIEHGEGKPvVVTVAQDDTAVAV 421
|
170 180 190
....*....|....*....|....*....|....*....
gi 1352907357 393 A--DQGKSLNEDDFTILTQRFWR----KSAHKQGYGLGL 425
Cdd:NF040691 422 TvrDHGVGLKPGEVALVFDRFWRadpaRARTTGGTGLGL 460
|
|
| HATPase_HupT_MifS-like |
cd16976 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
363-448 |
8.13e-04 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.
Pssm-ID: 340435 [Multi-domain] Cd Length: 102 Bit Score: 38.59 E-value: 8.13e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352907357 363 VLKNLIQNAYLHAEDAPNIQIYMQ------DLQLIIADQGKSLNEDDFTILTQRFWRKSAHKQGYGLGLTLVKVLLEQYG 436
Cdd:cd16976 4 VLMNLLQNALDAMGKVENPRIRIAarrlggRLVLVVRDNGPGIAEEHLSRVFDPFFTTKPVGKGTGLGLSISYGIVEEHG 83
|
90
....*....|..
gi 1352907357 437 YLLQFqANQPQG 448
Cdd:cd16976 84 GRLSV-ANEEGA 94
|
|
| HisKA |
smart00388 |
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ... |
239-292 |
1.70e-03 |
|
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.
Pssm-ID: 214644 [Multi-domain] Cd Length: 66 Bit Score: 36.78 E-value: 1.70e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 1352907357 239 KNFSAFAAHELRTPLTAIKTHVQlsqlMLNQTASAQDTAKVIDNLKHAERSIQR 292
Cdd:smart00388 3 REFLANLSHELRTPLTAIRGYLE----LLLDTELSEEQREYLETILREAERLLR 52
|
|
| phoR |
PRK11006 |
phosphate regulon sensor histidine kinase PhoR; |
217-429 |
1.72e-03 |
|
phosphate regulon sensor histidine kinase PhoR;
Pssm-ID: 182895 [Multi-domain] Cd Length: 430 Bit Score: 40.76 E-value: 1.72e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352907357 217 IQPFVDNLLMLIER----LHKSLEHEKNFSAFAAHELRTPLTAIKTHVQLSQlmlNQTASAQDTAKvidnlkhAERSIQR 292
Cdd:PRK11006 179 VMPYTEGQLLMVARdvtqMHQLEGARRNFFANVSHELRTPLTVLQGYLEMMQ---DQPLEGALREK-------ALHTMRE 248
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352907357 293 YQQLLEQLLLLSQTEAGIQAAHSHAdmrsvletvLSElTVEYPNLSAKLQIDWASLV--AQHINIPAPA----------L 360
Cdd:PRK11006 249 QTQRMEGLVKQLLTLSKIEAAPTID---------LNE-KVDVPMMLRVLEREAQTLSqgKHTITFEVDNslkvfgnedqL 318
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1352907357 361 HMVLKNLIQNAYLHAEDAPNIQIYMQDL----QLIIADQGKSLNEDDFTILTQRFWR----KSAHKQGYGLGLTLVK 429
Cdd:PRK11006 319 RSAISNLVYNAVNHTPEGTHITVRWQRVpqgaEFSVEDNGPGIAPEHIPRLTERFYRvdkaRSRQTGGSGLGLAIVK 395
|
|
| 2CSK_N |
pfam08521 |
Two-component sensor kinase N-terminal; This domain is found in bacterial two-component sensor ... |
19-154 |
2.06e-03 |
|
Two-component sensor kinase N-terminal; This domain is found in bacterial two-component sensor kinases towards the N-terminus. It recognizes Autoinducer 3 (AI-3), epinephrine, norepineprhine and Fe(III) (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 430051 Cd Length: 142 Bit Score: 38.39 E-value: 2.06e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352907357 19 ILLWVIVFAWLYHDLEQRLQNTLDERLSTSARMVARLIQ--------QLPlEQLTESLHAESEnallhSLIACEVSifra 90
Cdd:pfam08521 2 LLLWLLSAAITYRVARNAANRAYDRALLASARALAEQVRvedgelqvDLP-PAALEMLRADAE-----DRVYYQVL---- 71
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1352907357 91 dvSLPQHVIARTQGAPKNLKN-QQVGFSTWTENGLQWRSYVLR--------EGEVQVVVAEKIQLRQNLLKQI 154
Cdd:pfam08521 72 --DPDGRLLAGDADLPLPPGYaGEPRFYDAEYRGEPVRVAALArplagpgaSGPVLVQVAETLEKRDALAREI 142
|
|
| HATPase_RstB-like |
cd16939 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
360-436 |
3.75e-03 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.
Pssm-ID: 340416 [Multi-domain] Cd Length: 104 Bit Score: 37.02 E-value: 3.75e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352907357 360 LHMVLKNLIQNAYLHAEDAPNIQIYMQD--LQLIIADQGKSLNEDDFTILTQRFWR----KSAHKQGYGLGLTLVKVLLE 433
Cdd:cd16939 1 MARALDNLLRNALRYAHRTVRIALLVSGgrLTLIVEDDGPGIPAAARERVFEPFVRldpsRDRATGGFGLGLAIVHRVAL 80
|
...
gi 1352907357 434 QYG 436
Cdd:cd16939 81 WHG 83
|
|
| PRK11360 |
PRK11360 |
two-component system sensor histidine kinase AtoS; |
246-436 |
5.03e-03 |
|
two-component system sensor histidine kinase AtoS;
Pssm-ID: 236901 [Multi-domain] Cd Length: 607 Bit Score: 39.18 E-value: 5.03e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352907357 246 AHELRTPLTAIKTHVQLSQLMLNQTASAQDTA----------KVIDNL----KHAERSIQRYQQLLEQLlllsqtEAGIQ 311
Cdd:PRK11360 398 AHEIRNPLTAIRGYVQIWRQQTSDPPSQEYLSvvlrevdrlnKVIDQLlefsRPRESQWQPVSLNALVE------EVLQL 471
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352907357 312 AAHSHADMRSVLETVLSEltveypNLSAklqidwaslvaqhINIPAPALHMVLKNLIQNAYLHAEDAPNIQIYMQ----- 386
Cdd:PRK11360 472 FQTAGVQARVDFETELDN------ELPP-------------IWADPELLKQVLLNILINAVQAISARGKIRIRTWqysdg 532
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 1352907357 387 DLQLIIADQGKSLNEDDFTILTQRFWrkSAHKQGYGLGLTLVKVLLEQYG 436
Cdd:PRK11360 533 QVAVSIEDNGCGIDPELLKKIFDPFF--TTKAKGTGLGLALSQRIINAHG 580
|
|
| PRK10490 |
PRK10490 |
sensor protein KdpD; Provisional |
208-448 |
6.20e-03 |
|
sensor protein KdpD; Provisional
Pssm-ID: 236701 [Multi-domain] Cd Length: 895 Bit Score: 39.25 E-value: 6.20e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352907357 208 LRSQKIPkEIQPFVDNLLMLI----ERLHKS-------LEHE----KNfSAFAA--HELRTPLTAIktHVQLSQLMLNQT 270
Cdd:PRK10490 619 LRQLMIP-EQQRLLETFTLLIanalERLTLTaseeqarLASEreqlRN-ALLAAlsHDLRTPLTVL--FGQAEILTLDLA 694
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352907357 271 AsaqdtakviDNLKHAERS--IQRYQQLLEQLLLLSQTEAGIQAA--HSHADMRSVLETVLSEL-TVEYPNLSAKLQIDW 345
Cdd:PRK10490 695 S---------EGSPHARQAseIRQQVLNTTRLVNNLLDMARIQSGgfNLRKEWLTLEEVVGSALqMLEPGLSGHPINLSL 765
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352907357 346 -ASLVAqhINIPAPALHMVLKNLIQNAYLHAEDAPNIQIYM----QDLQLIIADQGKSLNEDDFTILTQRFWRksAHKQ- 419
Cdd:PRK10490 766 pEPLTL--IHVDGPLFERVLINLLENAVKYAGAQAEIGIDAhvegERLQLDVWDNGPGIPPGQEQLIFDKFAR--GNKEs 841
|
250 260 270
....*....|....*....|....*....|..
gi 1352907357 420 ---GYGLGLTLVKVLLEQYGYLLqFQANQPQG 448
Cdd:PRK10490 842 aipGVGLGLAICRAIVEVHGGTI-WAENRPEG 872
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