Uncharacterized ACR, COG1430; Two structures have been solved for members of this large (>500 members) family of bacterial proteins present mostly in environmental bacteria and metagenomes (distant homologs are also present in several Plasmodium species). TOPSAN analysis for pdb:3pjy shows that there is much similarity with the other solved structure, pdb:3m7a, solved for UniProt:Q2GA55 (Saro_0823), a homolog of Thermotoga maritima TM1668, UniProt:Q9X1Z6., The homolog in Caulobacter crescentus (CC1388), UniProt:Q9A8G6, is associated with CspD, a cold shock protein (CC1387), UniProt:Q9A8G7. However, the genomic context of UniProt:Q2GA55 is most conserved with a putative xylose isomerase, suggesting a possible role in extracellular sugar processing. Saro_0821, UniProt:Q2GA57, is annotated as an AMP-dependent synthetase and ligase. PDB:3m7a structure corresponds to the C-terminal (27-165) fragment of the YP_496102 (Saro_0823) protein and it is structurally unique, as the best hits from Dali have a Z-score of 3.8 (1nt0, 2j1t, 3kq4) and it is thus a likely candidate for a new fold. Interestingly, many of the top Dali hits are involved in sugar metabolism. There are no obvious active site-like cavities on the protein surface of 3m7a (http://www.topsan.org/Proteins/JCSG/).

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1353591948  52 KAELANTDLSRQIGLMNRKELDKNSGMLFVFKRSETQCMWMKNTLIDLDVAFADANGKILNIEQMKA-GTTDIHCSSGNA 130
Cdd:pfam02643   1 DVEVADTPEERARGLMFRTSLPEDEGMLFVFDRPQPHSFWMKNTLFPLDIIFIDADGRIVAIEENVPpCSEEPCPSPGPV 80

                          90       100
                  ....*....|....*....|....
gi 1353591948 131 KLALEMNHGWFSTRGLDTGEKLHV 154
Cdd:pfam02643  81 RYVLELPAGWAAKLGIKVGDRVEI 104

Uncharacterized ACR, COG1430; Two structures have been solved for members of this large (>500 members) family of bacterial proteins present mostly in environmental bacteria and metagenomes (distant homologs are also present in several Plasmodium species). TOPSAN analysis for pdb:3pjy shows that there is much similarity with the other solved structure, pdb:3m7a, solved for UniProt:Q2GA55 (Saro_0823), a homolog of Thermotoga maritima TM1668, UniProt:Q9X1Z6., The homolog in Caulobacter crescentus (CC1388), UniProt:Q9A8G6, is associated with CspD, a cold shock protein (CC1387), UniProt:Q9A8G7. However, the genomic context of UniProt:Q2GA55 is most conserved with a putative xylose isomerase, suggesting a possible role in extracellular sugar processing. Saro_0821, UniProt:Q2GA57, is annotated as an AMP-dependent synthetase and ligase. PDB:3m7a structure corresponds to the C-terminal (27-165) fragment of the YP_496102 (Saro_0823) protein and it is structurally unique, as the best hits from Dali have a Z-score of 3.8 (1nt0, 2j1t, 3kq4) and it is thus a likely candidate for a new fold. Interestingly, many of the top Dali hits are involved in sugar metabolism. There are no obvious active site-like cavities on the protein surface of 3m7a (http://www.topsan.org/Proteins/JCSG/).

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1353591948  52 KAELANTDLSRQIGLMNRKELDKNSGMLFVFKRSETQCMWMKNTLIDLDVAFADANGKILNIEQMKA-GTTDIHCSSGNA 130
Cdd:pfam02643   1 DVEVADTPEERARGLMFRTSLPEDEGMLFVFDRPQPHSFWMKNTLFPLDIIFIDADGRIVAIEENVPpCSEEPCPSPGPV 80

                          90       100
                  ....*....|....*....|....
gi 1353591948 131 KLALEMNHGWFSTRGLDTGEKLHV 154
Cdd:pfam02643  81 RYVLELPAGWAAKLGIKVGDRVEI 104