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Conserved domains on  [gi|1360833954|ref|WP_106100303|]
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MULTISPECIES: GntR family transcriptional regulator [Streptococcus]

Protein Classification

GntR family transcriptional regulator( domain architecture ID 11450764)

GntR-family transcriptional regulator is one of a group of transcriptional regulators with a conserved N-terminal helix-turn-helix DNA-binding domain and a diverse C-terminal effector-binding and oligomerization domain

Gene Ontology:  GO:0003677|GO:0003700
PubMed:  2060763|26172911|33509775|15808743

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
1-229 8.23e-72

DNA-binding transcriptional regulator, GntR family [Transcription];


:

Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 218.96  E-value: 8.23e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1360833954   1 MPKYEEIANILRDRIASGVYPVDSMLPIQSELSKEFGVSRMTIKKAVEILTIEGLIFSKQGNGTRVLNSSFWDkedskfR 80
Cdd:COG2188     4 VPLYLQIADALRERIESGELPPGDRLPSERELAEEFGVSRMTVRKALDELVEEGLLERRQGRGTFVAEPKIEY------P 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1360833954  81 LNNYNGLSQDLKNDERKLTSQIIQFAVEFPEAEIAERLQVEMTVPVYKIIRLRLLDDQPYVLEHTYMPCDLVPGLDESIL 160
Cdd:COG2188    78 LSRLTSFTEELRARGREPSTRVLSAERVPADEEVAEALGLPPGAPVLRIERLRLADGEPVALETSYLPAALFPGLLEEDL 157

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1360833954 161 -LQSIYAYLWDELNLKFAGSYRHITAEKPDEYDQNYLACQETDPILQVEQVVYLETGRPIEYSKSRNRFD 229
Cdd:COG2188   158 eTGSLYELLEERYGLRITRAEQRIEAVLADAEEAELLGVPPGAPVLVIERVTYDADGRPVEYSRSYYRGD 227
 
Name Accession Description Interval E-value
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
1-229 8.23e-72

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 218.96  E-value: 8.23e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1360833954   1 MPKYEEIANILRDRIASGVYPVDSMLPIQSELSKEFGVSRMTIKKAVEILTIEGLIFSKQGNGTRVLNSSFWDkedskfR 80
Cdd:COG2188     4 VPLYLQIADALRERIESGELPPGDRLPSERELAEEFGVSRMTVRKALDELVEEGLLERRQGRGTFVAEPKIEY------P 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1360833954  81 LNNYNGLSQDLKNDERKLTSQIIQFAVEFPEAEIAERLQVEMTVPVYKIIRLRLLDDQPYVLEHTYMPCDLVPGLDESIL 160
Cdd:COG2188    78 LSRLTSFTEELRARGREPSTRVLSAERVPADEEVAEALGLPPGAPVLRIERLRLADGEPVALETSYLPAALFPGLLEEDL 157

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1360833954 161 -LQSIYAYLWDELNLKFAGSYRHITAEKPDEYDQNYLACQETDPILQVEQVVYLETGRPIEYSKSRNRFD 229
Cdd:COG2188   158 eTGSLYELLEERYGLRITRAEQRIEAVLADAEEAELLGVPPGAPVLVIERVTYDADGRPVEYSRSYYRGD 227
UTRA smart00866
The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; ...
 96-229 8.40e-40

The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; It has a similar fold to HutC/FarR-like bacterial transcription factors of the GntR family. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules.


Pssm-ID: 214869 [Multi-domain]  Cd Length: 143  Bit Score: 134.34  E-value: 8.40e-40
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1360833954   96 RKLTSQIIQFAVEFPEAEIAERLQVEMTVPVYKIIRLRLLDDQPYVLEHTYMPCDLVPGLDESILLQSIYAYLWDELNLK 175
Cdd:smart00866   4 RKPTTKVLSFERVPADEELAEALGLPPGDPVYRIERLRLADGEPVALETTYLPAALFPGLLEEDLSGSLYEYLEERLGLK 83

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1360833954  176 FAGSYR---HITAEKPDEYDQNYLACQETDPILQVEQVVYLETGRPIEYSKSRNRFD 229
Cdd:smart00866  84 IVRSTRaeqTITAVLADEEEAELLGLPPGAPLLVVERVTYDDDGRPVEYSRSYYRGD 140
UTRA pfam07702
UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ...
 96-229 6.80e-37

UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain that has a similar fold to pfam04345. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules sugar phosphates and urocanate, Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 429607 [Multi-domain]  Cd Length: 141  Bit Score: 126.56  E-value: 6.80e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1360833954  96 RKLTSQIIQFAVEFPEAEIAERLQVEMTVPVYKIIRLRLLDDQPYVLEHTYMPCDLVPGLDESILLQ-SIYAYLWDELNL 174
Cdd:pfam07702   4 REPKTEVLSLEEVPASAEIAEALGLPPGEPVYRIERLRYADGEPVALEEDYLPAELVPDLLEEDLEEgSLYDYLEERYGL 83

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1360833954 175 KFAGSYRHITAEKPDEYDQNYLACQETDPILQVEQVVYLETGRPIEYSKSRNRFD 229
Cdd:pfam07702  84 PITRAEQTIEAVLADAEEAELLGISPGAPVLLIERVTYDQDGRPVEYSRSYYRGD 138
PRK09764 PRK09764
GntR family transcriptional regulator;
2-233 1.78e-29

GntR family transcriptional regulator;


Pssm-ID: 182065 [Multi-domain]  Cd Length: 240  Bit Score: 110.30  E-value: 1.78e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1360833954   2 PKYEEIANILRDRIASGVYPVDSMLPIQSELSKEFGVSRMTIKKAVEILTIEGLIFSKQGNGTRVlnssfwDKEDSKFRL 81
Cdd:PRK09764    5 PLYRQIADRIREQIARGELKPGDALPTESALQTEFGVSRVTVRQALRQLVEQQILESIQGSGTYV------KEERVNYDI 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1360833954  82 NNYNGLSQDLKNDERKLTSQIIQFAVEFPEAEIAERLQVEMTVPVYKIIRLRLLDDQPYVLEHTYMPCDLVPGLDESILL 161
Cdd:PRK09764   79 FQLTSFDEKLSDRHVDTHSEVLIFEVIPADDFLQQQLQITAQDRVWHVKRVRYRKQKPMALEETWMPLALFPDLTWQVME 158

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1360833954 162 QSIYAYLWDELNLKFAGSYRHITAEKPDEYDQNYLACQETDPILQVEQVVYLETGRPIEYskSRNRFDTRGY 233
Cdd:PRK09764  159 NSKYHFIEEVKKMVIDRSEQEIIPLMPTEEMSRLLNISQTKPILEKVSRGYLVDGRVFEY--SRNAFNTDDY 228
C_P_lyase_phnF TIGR02325
phosphonates metabolism transcriptional regulator PhnF; All members of the seed alignment for ...
 4-230 2.97e-27

phosphonates metabolism transcriptional regulator PhnF; All members of the seed alignment for this family are predicted helix-turn-helix transcriptional regulatory proteins of the broader gntR and are found associated with genes for the import and degradation of phosphonates and/or related compounds (e.g. phosphonites) with a direct C-P bond. [Transport and binding proteins, Anions, Regulatory functions, DNA interactions]


Pssm-ID: 131378 [Multi-domain]  Cd Length: 238  Bit Score: 104.48  E-value: 2.97e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1360833954   4 YEEIANILRDRIASGVYPVDSMLPIQSELSKEFGVSRMTIKKAVEILTIEGLIFSKQGNGTRVLNSSFwdkedsKFRLNN 83
Cdd:TIGR02325  10 WRQIADKIEQEIAAGHLRAGDYLPAEMQLAERFGVNRHTVRRAIAALVERGLLRAEQGRGTFVAARRI------DYPLSA 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1360833954  84 YNGLSQDLKNDERKLTSQIIQFAVEFPEAEIAERLQVEMTVPVYKIIRLRLLDDQPYVLEHTYMPCDLVPGLDESILLQ- 162
Cdd:TIGR02325  84 RTRFSQNLADQGREPTGELLLSDLEPASAELADALGLTVGAPLVRLETLRKADGRPLCRATTWFPAARFPGIGQAYAASg 163

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1360833954 163 SIYAYLWDELNLKFAGSYRHITAEKPDEYDQNYLACQETDPILQVEQVVYLETGRPIEYSKSRNRFDT 230
Cdd:TIGR02325 164 SITDALREQGVADYRRSSTRISARHADAKDCARLELPPGRPLLVVQALNHDGEGRPVQYSVSRFRADR 231
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 2-66 2.15e-22

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 86.73  E-value: 2.15e-22
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1360833954   2 PKYEEIANILRDRIASGVYPVDSMLPIQSELSKEFGVSRMTIKKAVEILTIEGLIFSKQGNGTRV 66
Cdd:cd07377     1 PLYEQIADQLREAILSGELKPGDRLPSERELAEELGVSRTTVREALRELEAEGLVERRPGRGTFV 65
 
Name Accession Description Interval E-value
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
1-229 8.23e-72

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 218.96  E-value: 8.23e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1360833954   1 MPKYEEIANILRDRIASGVYPVDSMLPIQSELSKEFGVSRMTIKKAVEILTIEGLIFSKQGNGTRVLNSSFWDkedskfR 80
Cdd:COG2188     4 VPLYLQIADALRERIESGELPPGDRLPSERELAEEFGVSRMTVRKALDELVEEGLLERRQGRGTFVAEPKIEY------P 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1360833954  81 LNNYNGLSQDLKNDERKLTSQIIQFAVEFPEAEIAERLQVEMTVPVYKIIRLRLLDDQPYVLEHTYMPCDLVPGLDESIL 160
Cdd:COG2188    78 LSRLTSFTEELRARGREPSTRVLSAERVPADEEVAEALGLPPGAPVLRIERLRLADGEPVALETSYLPAALFPGLLEEDL 157

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1360833954 161 -LQSIYAYLWDELNLKFAGSYRHITAEKPDEYDQNYLACQETDPILQVEQVVYLETGRPIEYSKSRNRFD 229
Cdd:COG2188   158 eTGSLYELLEERYGLRITRAEQRIEAVLADAEEAELLGVPPGAPVLVIERVTYDADGRPVEYSRSYYRGD 227
UTRA smart00866
The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; ...
 96-229 8.40e-40

The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; It has a similar fold to HutC/FarR-like bacterial transcription factors of the GntR family. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules.


Pssm-ID: 214869 [Multi-domain]  Cd Length: 143  Bit Score: 134.34  E-value: 8.40e-40
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1360833954   96 RKLTSQIIQFAVEFPEAEIAERLQVEMTVPVYKIIRLRLLDDQPYVLEHTYMPCDLVPGLDESILLQSIYAYLWDELNLK 175
Cdd:smart00866   4 RKPTTKVLSFERVPADEELAEALGLPPGDPVYRIERLRLADGEPVALETTYLPAALFPGLLEEDLSGSLYEYLEERLGLK 83

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1360833954  176 FAGSYR---HITAEKPDEYDQNYLACQETDPILQVEQVVYLETGRPIEYSKSRNRFD 229
Cdd:smart00866  84 IVRSTRaeqTITAVLADEEEAELLGLPPGAPLLVVERVTYDDDGRPVEYSRSYYRGD 140
UTRA pfam07702
UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ...
 96-229 6.80e-37

UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain that has a similar fold to pfam04345. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules sugar phosphates and urocanate, Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 429607 [Multi-domain]  Cd Length: 141  Bit Score: 126.56  E-value: 6.80e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1360833954  96 RKLTSQIIQFAVEFPEAEIAERLQVEMTVPVYKIIRLRLLDDQPYVLEHTYMPCDLVPGLDESILLQ-SIYAYLWDELNL 174
Cdd:pfam07702   4 REPKTEVLSLEEVPASAEIAEALGLPPGEPVYRIERLRYADGEPVALEEDYLPAELVPDLLEEDLEEgSLYDYLEERYGL 83

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1360833954 175 KFAGSYRHITAEKPDEYDQNYLACQETDPILQVEQVVYLETGRPIEYSKSRNRFD 229
Cdd:pfam07702  84 PITRAEQTIEAVLADAEEAELLGISPGAPVLLIERVTYDQDGRPVEYSRSYYRGD 138
PRK09764 PRK09764
GntR family transcriptional regulator;
2-233 1.78e-29

GntR family transcriptional regulator;


Pssm-ID: 182065 [Multi-domain]  Cd Length: 240  Bit Score: 110.30  E-value: 1.78e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1360833954   2 PKYEEIANILRDRIASGVYPVDSMLPIQSELSKEFGVSRMTIKKAVEILTIEGLIFSKQGNGTRVlnssfwDKEDSKFRL 81
Cdd:PRK09764    5 PLYRQIADRIREQIARGELKPGDALPTESALQTEFGVSRVTVRQALRQLVEQQILESIQGSGTYV------KEERVNYDI 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1360833954  82 NNYNGLSQDLKNDERKLTSQIIQFAVEFPEAEIAERLQVEMTVPVYKIIRLRLLDDQPYVLEHTYMPCDLVPGLDESILL 161
Cdd:PRK09764   79 FQLTSFDEKLSDRHVDTHSEVLIFEVIPADDFLQQQLQITAQDRVWHVKRVRYRKQKPMALEETWMPLALFPDLTWQVME 158

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1360833954 162 QSIYAYLWDELNLKFAGSYRHITAEKPDEYDQNYLACQETDPILQVEQVVYLETGRPIEYskSRNRFDTRGY 233
Cdd:PRK09764  159 NSKYHFIEEVKKMVIDRSEQEIIPLMPTEEMSRLLNISQTKPILEKVSRGYLVDGRVFEY--SRNAFNTDDY 228
PRK11402 PRK11402
transcriptional regulator PhoB;
2-222 1.81e-28

transcriptional regulator PhoB;


Pssm-ID: 183118 [Multi-domain]  Cd Length: 241  Bit Score: 108.00  E-value: 1.81e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1360833954   2 PKYEEIANILRDRIASGVYPVDSMLPIQSELSKEFGVSRMTIKKAVEILTIEGLIFSKQGNGTrvlnssFWDKEDSKFRL 81
Cdd:PRK11402    9 LLYATVRQRLLDDIAQGVYQAGQQIPTENELCTQYNVSRITIRKAISDLVADGVLIRWQGKGT------FVQSQKVENAL 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1360833954  82 NNYNGLSQDLKNDERKLTSQIIQFAVEFPeAEIAERLQVEMTVPVYKIIRLRLLDDQPYVLEHTYMPCDLVPGLDESILL 161
Cdd:PRK11402   83 LTVSGFTDFGVSQGKATKEKVIEQERVSA-APFCEKLNIPGNSEVFHLCRVMYLDKEPLFIDSSWIPLSRYPDFDEIYVE 161

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1360833954 162 Q-SIYAYLWDELNLKFAGSYRHITAEKPDEYDQNYLACQETDPILQVEQVVYLETGRPIEYS 222
Cdd:PRK11402  162 GsSTYQLFQERFDTRVVSDKKTIDIFAATRPEAKWLKCELGEPLFRISKIAFDQNDKPVHVS 223
C_P_lyase_phnF TIGR02325
phosphonates metabolism transcriptional regulator PhnF; All members of the seed alignment for ...
 4-230 2.97e-27

phosphonates metabolism transcriptional regulator PhnF; All members of the seed alignment for this family are predicted helix-turn-helix transcriptional regulatory proteins of the broader gntR and are found associated with genes for the import and degradation of phosphonates and/or related compounds (e.g. phosphonites) with a direct C-P bond. [Transport and binding proteins, Anions, Regulatory functions, DNA interactions]


Pssm-ID: 131378 [Multi-domain]  Cd Length: 238  Bit Score: 104.48  E-value: 2.97e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1360833954   4 YEEIANILRDRIASGVYPVDSMLPIQSELSKEFGVSRMTIKKAVEILTIEGLIFSKQGNGTRVLNSSFwdkedsKFRLNN 83
Cdd:TIGR02325  10 WRQIADKIEQEIAAGHLRAGDYLPAEMQLAERFGVNRHTVRRAIAALVERGLLRAEQGRGTFVAARRI------DYPLSA 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1360833954  84 YNGLSQDLKNDERKLTSQIIQFAVEFPEAEIAERLQVEMTVPVYKIIRLRLLDDQPYVLEHTYMPCDLVPGLDESILLQ- 162
Cdd:TIGR02325  84 RTRFSQNLADQGREPTGELLLSDLEPASAELADALGLTVGAPLVRLETLRKADGRPLCRATTWFPAARFPGIGQAYAASg 163

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1360833954 163 SIYAYLWDELNLKFAGSYRHITAEKPDEYDQNYLACQETDPILQVEQVVYLETGRPIEYSKSRNRFDT 230
Cdd:TIGR02325 164 SITDALREQGVADYRRSSTRISARHADAKDCARLELPPGRPLLVVQALNHDGEGRPVQYSVSRFRADR 231
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 2-66 2.15e-22

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 86.73  E-value: 2.15e-22
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1360833954   2 PKYEEIANILRDRIASGVYPVDSMLPIQSELSKEFGVSRMTIKKAVEILTIEGLIFSKQGNGTRV 66
Cdd:cd07377     1 PLYEQIADQLREAILSGELKPGDRLPSERELAEELGVSRTTVREALRELEAEGLVERRPGRGTFV 65
FadR COG2186
DNA-binding transcriptional regulator, FadR family [Transcription];
4-72 2.76e-18

DNA-binding transcriptional regulator, FadR family [Transcription];


Pssm-ID: 441789 [Multi-domain]  Cd Length: 232  Bit Score: 80.36  E-value: 2.76e-18
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1360833954   4 YEEIANILRDRIASGVYPVDSMLPIQSELSKEFGVSRMTIKKAVEILTIEGLIFSKQGNGTRVLNSSFW 72
Cdd:COG2186     9 AEQVAEQLRELILSGELKPGDRLPSERELAEQLGVSRTTVREALRALEALGLVEVRQGGGTFVREPSPW 77
GntR pfam00392
Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the ...
 3-66 1.80e-17

Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the N-terminal HTH region of GntR-like bacterial transcription factors. At the C-terminus there is usually an effector-binding/oligomerization domain. The GntR-like proteins include the following sub-families: MocR, YtrR, FadR, AraR, HutC and PlmA, DevA, DasR. Many of these proteins have been shown experimentally to be autoregulatory, enabling the prediction of operator sites and the discovery of cis/trans relationships. The DasR regulator has been shown to be a global regulator of primary metabolism and development in Streptomyces coelicolor.


Pssm-ID: 306822 [Multi-domain]  Cd Length: 64  Bit Score: 73.80  E-value: 1.80e-17
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1360833954   3 KYEEIANILRDRIASGVYPVDSMLPIQSELSKEFGVSRMTIKKAVEILTIEGLIFSKQGNGTRV 66
Cdd:pfam00392   1 LYEQVYARLREDILSGRLRPGDKLPSERELAAEFGVSRTTVREALRRLEAEGLVERRQGRGTFV 64
HTH_GNTR smart00345
helix_turn_helix gluconate operon transcriptional repressor;
7-66 9.77e-15

helix_turn_helix gluconate operon transcriptional repressor;


Pssm-ID: 197669 [Multi-domain]  Cd Length: 60  Bit Score: 66.44  E-value: 9.77e-15
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1360833954    7 IANILRDRIASGVYPVDSMLPIQSELSKEFGVSRMTIKKAVEILTIEGLIFSKQGNGTRV 66
Cdd:smart00345   1 VAERLREDIVSGELRPGDKLPSERELAAQLGVSRTTVREALSRLEAEGLVQRRPGSGTFV 60
ARO8 COG1167
DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain ...
 1-66 3.06e-14

DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain [Transcription, Amino acid transport and metabolism]; DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain is part of the Pathway/BioSystem: Lysine biosynthesis


Pssm-ID: 440781 [Multi-domain]  Cd Length: 471  Bit Score: 71.40  E-value: 3.06e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1360833954   1 MPKYEEIANILRDRIASGVYPVDSMLPIQSELSKEFGVSRMTIKKAVEILTIEGLIFSKQGNGTRV 66
Cdd:COG1167    11 GPLYLQLADALREAILSGRLPPGDRLPSSRELAAQLGVSRSTVVRAYEELEAEGLIESRPGSGTFV 76
PRK14999 PRK14999
histidine utilization repressor; Provisional
 2-66 2.53e-10

histidine utilization repressor; Provisional


Pssm-ID: 184961 [Multi-domain]  Cd Length: 241  Bit Score: 58.79  E-value: 2.53e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1360833954   2 PKYEEIANILRDRIASGVYPVDSMLPIQSELSKEFGVSRMTIKKAVEILTIEGLIFSKQGNGTRV 66
Cdd:PRK14999   12 PFYETVKQDICKKIAGGVWQPHDRIPSEAELVAQYGFSRMTINRALRELTDEGWLVRLQGVGTFV 76
PRK11523 PRK11523
transcriptional regulator ExuR;
4-69 2.13e-08

transcriptional regulator ExuR;


Pssm-ID: 183176 [Multi-domain]  Cd Length: 253  Bit Score: 53.31  E-value: 2.13e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1360833954   4 YEEIANILRDRIASGVYPVDSMLPIQSELSKEFGVSRMTIKKAVEILTIEGLIFSKQGNGTRVLNS 69
Cdd:PRK11523   10 YQQLAAELKERIEQGVYLVGDKLPAERFIADEKNVSRTVVREAIIMLEVEGYVEVRKGSGIHVVSN 75
GntR COG1802
DNA-binding transcriptional regulator, GntR family [Transcription];
5-66 3.25e-08

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441407 [Multi-domain]  Cd Length: 222  Bit Score: 52.23  E-value: 3.25e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1360833954   5 EEIANILRDRIASGVYPVDSMLPIQsELSKEFGVSRMTIKKAVEILTIEGLIFSKQGNGTRV 66
Cdd:COG1802    14 EQVYEALREAILSGELPPGERLSEA-ELAERLGVSRTPVREALRRLEAEGLVEIRPNRGARV 74
PRK10225 PRK10225
Uxu operon transcriptional regulator;
4-70 8.55e-07

Uxu operon transcriptional regulator;


Pssm-ID: 182318 [Multi-domain]  Cd Length: 257  Bit Score: 48.48  E-value: 8.55e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1360833954   4 YEEIANILRDRIASGVYPVDSMLPIQSELSKEFGVSRMTIKKAVEILTIEGLIFSKQGNGTRVLNSS 70
Cdd:PRK10225   11 YQEVGAMIRDLIIKTPYNPGERLPPEREIAEMLDVTRTVVREALIMLEIKGLVEVRRGAGIYVLDSS 77
pdhR PRK09464
pyruvate dehydrogenase complex transcriptional repressor PdhR;
26-73 1.74e-05

pyruvate dehydrogenase complex transcriptional repressor PdhR;


Pssm-ID: 181879 [Multi-domain]  Cd Length: 254  Bit Score: 44.63  E-value: 1.74e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1360833954  26 LPIQSELSKEFGVSRMTIKKAVEILTIEGLIFSKQGNGTRV---LNSSFWD 73
Cdd:PRK09464   34 LPPERELAKQFDVSRPSLREAIQRLEAKGLLLRRQGGGTFVqssLWQSFSD 84
PRK10079 PRK10079
phosphonate metabolism transcriptional regulator PhnF; Provisional
 3-229 1.77e-05

phosphonate metabolism transcriptional regulator PhnF; Provisional


Pssm-ID: 182227 [Multi-domain]  Cd Length: 241  Bit Score: 44.38  E-value: 1.77e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1360833954   3 KYEEIANILRDRIaSGVYPVDSMLPIQSELSKEFGVSRMTIKKAVEILTIEGLIFSKQGNGTRVLNSSFwdkedsKFRLN 82
Cdd:PRK10079   13 RYQEIAAKLEQEL-RQHYRCGDYLPAEQQLAARYEVNRHTLRRAIDQLVEKGWVQRRQGVGVLVLMRPY------DYPLN 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1360833954  83 NYNGLSQDLKNDERKLTSQIIQFAVEFPEAEIAERLQVEMTVPVYKIIRLRLLDDQPYVLEHTYMP-CDLVPGLdESILL 161
Cdd:PRK10079   86 AQARFSQNLLDQGSHPTSEKLLSVLRPASGHVADALGITEGENVIHLRTLRRVNGVALCLIDHYFAdLTWWPTL-QRFDS 164

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1360833954 162 QSIYAYLWDELNLKFAGSYRHITAEKPDEYDQNYLACQETDPILQVEQVVYLET-GRPIEYSKSRNRFD 229
Cdd:PRK10079  165 GSLHDFLREQLGIALRRSQTRISARRAQAKESQLLEIPNMSPLLCVRTLNHRDGeSSPAEYSVSLTRAD 233
PRK10421 PRK10421
DNA-binding transcriptional repressor LldR; Provisional
 1-66 3.47e-05

DNA-binding transcriptional repressor LldR; Provisional


Pssm-ID: 236690 [Multi-domain]  Cd Length: 253  Bit Score: 43.60  E-value: 3.47e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1360833954   1 MPKYEEIANILRDRIASGVYPVDSMLPIQSELSKEFGVSRMTIKKAVEILTIEGLIFSKQGNGTRV 66
Cdd:PRK10421    1 RRLSDEVADRVRALIEEKNLEAGMKLPAERQLAMQLGVSRNSLREALAKLVSEGVLLSRRGGGTFI 66
HTH_11 pfam08279
HTH domain; This family includes helix-turn-helix domains in a wide variety of proteins.
 30-63 1.52e-03

HTH domain; This family includes helix-turn-helix domains in a wide variety of proteins.


Pssm-ID: 429896 [Multi-domain]  Cd Length: 52  Bit Score: 35.49  E-value: 1.52e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1360833954  30 SELSKEFGVSRMTIKKAVEILTIEGL-IFSKQGNG 63
Cdd:pfam08279  17 QELAEKLGVSRRTIRRDIKILEELGVpIEAEPGRG 51
PRK15481 PRK15481
transcriptional regulatory protein PtsJ; Provisional
 5-64 5.18e-03

transcriptional regulatory protein PtsJ; Provisional


Pssm-ID: 185378 [Multi-domain]  Cd Length: 431  Bit Score: 37.72  E-value: 5.18e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1360833954   5 EEIANILRDRIASGVYPVDSMLPIQSELSKEFGVSRMTIKKAVEILTIEGLIFSKQGNGT 64
Cdd:PRK15481    8 NEIFDSIRQLIQAGRLRPGDSLPPVRELASELGVNRNTVAAAYKRLVTAGLAQSQGRNGT 67
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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