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Conserved domains on  [gi|1382076079|ref|WP_107949082|]
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MULTISPECIES: VanZ family protein [Shewanella]

Protein Classification

VanZ family protein( domain architecture ID 10009512)

VanZ family protein is an integral membrane protein similar to Enterococcus faecium protein VanZ, which confers low-level resistance to the glycopeptide antibiotic teicoplanin (Te)

Gene Ontology:  GO:0005576|GO:0071555|GO:0046677

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
VanZ COG5652
VanZ-like family protein (function unknown) [Function unknown];
7-104 1.59e-13

VanZ-like family protein (function unknown) [Function unknown];


:

Pssm-ID: 444373  Cd Length: 128  Bit Score: 61.94  E-value: 1.59e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382076079   7 LFKLALAVAFVVISYLVF-----SRPTYSQSIPNIDKVGHLGSFFCLSYLSYLAFRP------KWYWLSLTLAS-YAILI 74
Cdd:COG5652     9 LRWLLVLLWAGLIFYLSLqpgeeSPSLSGLVFFGFDKLAHFLAYFILGFLLALALRRsrlrrrRALLLAVLIAVlYAILD 88

                          90       100       110
                  ....*....|....*....|....*....|
gi 1382076079  75 ELVQSRLPYRSASVADVIADFAGIALFYFC 104
Cdd:COG5652    89 EIHQSFVPGRSASLADVLADTLGALLGVLL 118
 
Name Accession Description Interval E-value
VanZ COG5652
VanZ-like family protein (function unknown) [Function unknown];
7-104 1.59e-13

VanZ-like family protein (function unknown) [Function unknown];


Pssm-ID: 444373  Cd Length: 128  Bit Score: 61.94  E-value: 1.59e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382076079   7 LFKLALAVAFVVISYLVF-----SRPTYSQSIPNIDKVGHLGSFFCLSYLSYLAFRP------KWYWLSLTLAS-YAILI 74
Cdd:COG5652     9 LRWLLVLLWAGLIFYLSLqpgeeSPSLSGLVFFGFDKLAHFLAYFILGFLLALALRRsrlrrrRALLLAVLIAVlYAILD 88

                          90       100       110
                  ....*....|....*....|....*....|
gi 1382076079  75 ELVQSRLPYRSASVADVIADFAGIALFYFC 104
Cdd:COG5652    89 EIHQSFVPGRSASLADVLADTLGALLGVLL 118
vanZ_1 NF037970
VanZ family protein; VanZ was originally identified in Enterococcus faecium. VanZ increases ...
 36-97 6.76e-09

VanZ family protein; VanZ was originally identified in Enterococcus faecium. VanZ increases teicoplanin resistance in Enterococcus faecium, but has no impact on vancomycin resistance. Proteins of this family are homologs of the VanZ protein. They may be involved in teicoplanin resistance.


Pssm-ID: 468295  Cd Length: 107  Bit Score: 49.52  E-value: 6.76e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1382076079  36 IDKVGHLGSFFCLSYLSYLAFRPKW-----YWLSLTLAS-YAILIELVQSRLPYRSASVADVIADFAG 97
Cdd:NF037970   39 IRKWAHFFAYFILAILLFLALGKFRkkgksKLLALLLCVlYAVSDEFHQSFVPGRSPDVRDVLIDSIG 106
VanZ pfam04892
VanZ like family; This family contains several examples of the VanZ protein, but also contains ...
 45-104 1.96e-04

VanZ like family; This family contains several examples of the VanZ protein, but also contains examples of phosphotransbutyrylases.


Pssm-ID: 461467  Cd Length: 79  Bit Score: 37.07  E-value: 1.96e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382076079  45 FFCLSYLSYLAFRPKWYWLSLTLASYAILIELVQSRLPYRSASVADVIADFAGIALFYFC 104
Cdd:pfam04892  17 FVPFGFLLPLLFKRRFLKTLLLGFLYSLSDELHQLFVPGRSFDVDDVILNTLGALIGILL 76
 
Name Accession Description Interval E-value
VanZ COG5652
VanZ-like family protein (function unknown) [Function unknown];
7-104 1.59e-13

VanZ-like family protein (function unknown) [Function unknown];


Pssm-ID: 444373  Cd Length: 128  Bit Score: 61.94  E-value: 1.59e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382076079   7 LFKLALAVAFVVISYLVF-----SRPTYSQSIPNIDKVGHLGSFFCLSYLSYLAFRP------KWYWLSLTLAS-YAILI 74
Cdd:COG5652     9 LRWLLVLLWAGLIFYLSLqpgeeSPSLSGLVFFGFDKLAHFLAYFILGFLLALALRRsrlrrrRALLLAVLIAVlYAILD 88

                          90       100       110
                  ....*....|....*....|....*....|
gi 1382076079  75 ELVQSRLPYRSASVADVIADFAGIALFYFC 104
Cdd:COG5652    89 EIHQSFVPGRSASLADVLADTLGALLGVLL 118
vanZ_1 NF037970
VanZ family protein; VanZ was originally identified in Enterococcus faecium. VanZ increases ...
 36-97 6.76e-09

VanZ family protein; VanZ was originally identified in Enterococcus faecium. VanZ increases teicoplanin resistance in Enterococcus faecium, but has no impact on vancomycin resistance. Proteins of this family are homologs of the VanZ protein. They may be involved in teicoplanin resistance.


Pssm-ID: 468295  Cd Length: 107  Bit Score: 49.52  E-value: 6.76e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1382076079  36 IDKVGHLGSFFCLSYLSYLAFRPKW-----YWLSLTLAS-YAILIELVQSRLPYRSASVADVIADFAG 97
Cdd:NF037970   39 IRKWAHFFAYFILAILLFLALGKFRkkgksKLLALLLCVlYAVSDEFHQSFVPGRSPDVRDVLIDSIG 106
VanZ pfam04892
VanZ like family; This family contains several examples of the VanZ protein, but also contains ...
 45-104 1.96e-04

VanZ like family; This family contains several examples of the VanZ protein, but also contains examples of phosphotransbutyrylases.


Pssm-ID: 461467  Cd Length: 79  Bit Score: 37.07  E-value: 1.96e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382076079  45 FFCLSYLSYLAFRPKWYWLSLTLASYAILIELVQSRLPYRSASVADVIADFAGIALFYFC 104
Cdd:pfam04892  17 FVPFGFLLPLLFKRRFLKTLLLGFLYSLSDELHQLFVPGRSFDVDDVILNTLGALIGILL 76
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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