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Conserved domains on  [gi|1390596300|ref|WP_109104877|]
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NAD(P)/FAD-dependent oxidoreductase [Acinetobacter baumannii]

Protein Classification

flavin-containing monooxygenase( domain architecture ID 11449697)

flavin-containing monooxygenase (FMO) catalyses the flavin-dependent oxidation of ketones and cyclic ketones to esters and lactones, by using molecular oxygen and NAD(P)H.

CATH:  3.50.50.60
Gene Ontology:  GO:0016709|GO:0004497|GO:0050660
PubMed:  20015679|33588053

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CzcO COG2072
Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ...
 20-463 7.80e-161

Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ion transport and metabolism];


:

Pssm-ID: 441675 [Multi-domain]  Cd Length: 414  Bit Score: 462.80  E-value: 7.80e-161
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390596300  20 HAIQKTKIAIIGAGFGGLAMAIRLLQsQQSDFFILEKSNDVGGTWRENRYPGAACDVQSHMYSLSFAPKTDWSKRYAEAP 99
Cdd:COG2072     2 AATEHVDVVVIGAGQAGLAAAYHLRR-AGIDFVVLEKADDVGGTWRDNRYPGLRLDTPSHLYSLPFFPNWSDDPDFPTGD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390596300 100 EIFDYIQDITNQYQIKNYCKFNHEVTHVQYDEVRHIWTLDFANQPSLEAQFVVFASGPLHIPQIPHIQGIEKFKGKVFHS 179
Cdd:COG2072    81 EILAYLEAYADKFGLRRPIRFGTEVTSARWDEADGRWTVTTDDGETLTARFVVVATGPLSRPKIPDIPGLEDFAGEQLHS 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390596300 180 SQWEHDYSLEGKSVASIGTGGSAIQYIPEIAKDVKQLYVFQRTAAWVIPRDerkysnlskalfkksNLYRQIHRSRLYWS 259
Cdd:COG2072   161 ADWRNPVDLAGKRVLVVGTGASAVQIAPELARVAAHVTVFQRTPPWVLPRP---------------NYDPERGRPANYLG 225

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390596300 260 NESRvVPIVQPQIMkygqKLAEAFIRFQVKDKDLaKKLTPDFVMGCKRILISNKYFPTFNRKNVELVTEGIQEIKENSII 339
Cdd:COG2072   226 LEAP-PALNRRDAR----AWLRRLLRAQVKDPEL-GLLTPDYPPGCKRPLLSTDYYEALRRGNVELVTGGIERITEDGVV 299

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390596300 340 TKDGKERPIDCLIYGTGFVTDPRiYLKHFTCIGRNQielkqawKNGAESYYGIMTKNFPNLFqLVGPNTVLGHNSIIFMI 419
Cdd:COG2072   300 FADGTEHEVDVIVWATGFRADLP-WLAPLDVRGRDG-------RSGPRAYLGVVVPGFPNLF-FLGPNSPSGHSSLTLGA 370

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....
gi 1390596300 420 ESQVNYILQLIDLVEKSGQHAIEIKPEVQDSFNERIQTQLQGTV 463
Cdd:COG2072   371 ERQARYIARLIAHMRRRGAAAIEVRPEAEDAFNARLQRRAARTV 414
 
Name Accession Description Interval E-value
CzcO COG2072
Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ...
 20-463 7.80e-161

Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ion transport and metabolism];


Pssm-ID: 441675 [Multi-domain]  Cd Length: 414  Bit Score: 462.80  E-value: 7.80e-161
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390596300  20 HAIQKTKIAIIGAGFGGLAMAIRLLQsQQSDFFILEKSNDVGGTWRENRYPGAACDVQSHMYSLSFAPKTDWSKRYAEAP 99
Cdd:COG2072     2 AATEHVDVVVIGAGQAGLAAAYHLRR-AGIDFVVLEKADDVGGTWRDNRYPGLRLDTPSHLYSLPFFPNWSDDPDFPTGD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390596300 100 EIFDYIQDITNQYQIKNYCKFNHEVTHVQYDEVRHIWTLDFANQPSLEAQFVVFASGPLHIPQIPHIQGIEKFKGKVFHS 179
Cdd:COG2072    81 EILAYLEAYADKFGLRRPIRFGTEVTSARWDEADGRWTVTTDDGETLTARFVVVATGPLSRPKIPDIPGLEDFAGEQLHS 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390596300 180 SQWEHDYSLEGKSVASIGTGGSAIQYIPEIAKDVKQLYVFQRTAAWVIPRDerkysnlskalfkksNLYRQIHRSRLYWS 259
Cdd:COG2072   161 ADWRNPVDLAGKRVLVVGTGASAVQIAPELARVAAHVTVFQRTPPWVLPRP---------------NYDPERGRPANYLG 225

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390596300 260 NESRvVPIVQPQIMkygqKLAEAFIRFQVKDKDLaKKLTPDFVMGCKRILISNKYFPTFNRKNVELVTEGIQEIKENSII 339
Cdd:COG2072   226 LEAP-PALNRRDAR----AWLRRLLRAQVKDPEL-GLLTPDYPPGCKRPLLSTDYYEALRRGNVELVTGGIERITEDGVV 299

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390596300 340 TKDGKERPIDCLIYGTGFVTDPRiYLKHFTCIGRNQielkqawKNGAESYYGIMTKNFPNLFqLVGPNTVLGHNSIIFMI 419
Cdd:COG2072   300 FADGTEHEVDVIVWATGFRADLP-WLAPLDVRGRDG-------RSGPRAYLGVVVPGFPNLF-FLGPNSPSGHSSLTLGA 370

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....
gi 1390596300 420 ESQVNYILQLIDLVEKSGQHAIEIKPEVQDSFNERIQTQLQGTV 463
Cdd:COG2072   371 ERQARYIARLIAHMRRRGAAAIEVRPEAEDAFNARLQRRAARTV 414
FMO-like pfam00743
Flavin-binding monooxygenase-like; This family includes FMO proteins, cyclohexanone ...
 24-357 5.05e-20

Flavin-binding monooxygenase-like; This family includes FMO proteins, cyclohexanone mono-oxygenase and a number of different mono-oxygenases.


Pssm-ID: 395602 [Multi-domain]  Cd Length: 531  Bit Score: 93.30  E-value: 5.05e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390596300  24 KTKIAIIGAGFGGLAmAIRLLQSQQSDFFILEKSNDVGGTWR--ENRYPGAACDVQS-------HMYSLSFAPKTDWSKR 94
Cdd:pfam00743   1 AKKVAVIGAGVSGLA-SIKCCLEEGLEPTCFERSDDIGGLWRftENVEEGRASIYKSvitntskEMSCFSDFPFPEDYPN 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390596300  95 YAEAPEIFDYIQDITNQYQIKNYCKFNHEVTHV----------QYDEVrhiwTLDFANQPSLEAQFVVFASGPLHIPQIP 164
Cdd:pfam00743  80 FMHNSKFLEYFRMFAKEFDLLKYIQFKTTVCSVkkrpdfstsgQWEVV----TEHEGKQESAVFDAVMVCTGHHTNPHLP 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390596300 165 --HIQGIEKFKGKVFHSSQWEHDYSLEGKSVASIGTGGSAIQYIPEIAKDVKQLYVFQRTAAWVIPR---DERKYSNLSK 239
Cdd:pfam00743 156 leSFPGIEKFKGQYFHSRDYKHPEGFTGKRVLVIGIGNSGGDIAVELSHTAAQVFLSTRRGSWVLSRvsdHGYPWDMLFS 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390596300 240 ALFkKSNLYRQIHRSRLYWSNESrvvpivqpqimKYGQKLAEAFIRFQVKDKDLAKKLT-PDFVMGCkriLISNKYFptf 318
Cdd:pfam00743 236 TRF-TSFLRNILPTSISNWLMEK-----------QMNRRFNHENYGLKPKNRALSKEPVvNDDLPNR---ILCGAVK--- 297

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|
gi 1390596300 319 nrknvelVTEGIQEIKENSIITKDG-KERPIDCLIYGTGF 357
Cdd:pfam00743 298 -------VKPNVKEFTETSAIFEDGtVEEDIDVVIFATGY 330
PLN02172 PLN02172
flavin-containing monooxygenase FMO GS-OX
 19-221 1.93e-12

flavin-containing monooxygenase FMO GS-OX


Pssm-ID: 215116 [Multi-domain]  Cd Length: 461  Bit Score: 69.12  E-value: 1.93e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390596300  19 QHAIQKTKIAIIGAGFGGLAMAiRLLQSQQSDFFILEKSNDVGGTWreNRYPGAACD----------VQSHMYS------ 82
Cdd:PLN02172    5 QNPINSQHVAVIGAGAAGLVAA-RELRREGHTVVVFEREKQVGGLW--VYTPKSESDplsldptrsiVHSSVYEslrtnl 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390596300  83 ---------LSFAPKTDW----SKRYAEAPEIFDYIQDITNQYQIKNYCKFNHEVTHVQydEVRHIWTL------DFANQ 143
Cdd:PLN02172   82 precmgyrdFPFVPRFDDesrdSRRYPSHREVLAYLQDFAREFKIEEMVRFETEVVRVE--PVDGKWRVqsknsgGFSKD 159

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1390596300 144 PSLEAqfVVFASGPLHIPQIPHIQGIEKFKGKVFHSSQWEHDYSLEGKSVASIGTGGSAIQYIPEIAKDVKQLYVFQR 221
Cdd:PLN02172  160 EIFDA--VVVCNGHYTEPNVAHIPGIKSWPGKQIHSHNYRVPDPFKNEVVVVIGNFASGADISRDIAKVAKEVHIASR 235
crtI_fam TIGR02734
phytoene desaturase; Phytoene is converted to lycopene by desaturation at four (two ...
 29-62 3.93e-03

phytoene desaturase; Phytoene is converted to lycopene by desaturation at four (two symmetrical pairs of) sites. This is achieved by two enzymes (crtP and crtQ) in cyanobacteria (Gloeobacter being an exception) and plants, but by a single enzyme in most other bacteria and in fungi. This single enzyme is called the bacterial-type phytoene desaturase, or CrtI. Most members of this family, part of the larger pfam01593, which also contains amino oxidases, are CrtI itself; it is likely that all members act on either phytoene or on related compounds such as dehydrosqualene, for carotenoid biosynthesis. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other]


Pssm-ID: 274273 [Multi-domain]  Cd Length: 495  Bit Score: 39.95  E-value: 3.93e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1390596300  29 IIGAGFGGLAMAIRlLQSQQSDFFILEKSNDVGG 62
Cdd:TIGR02734   3 VIGAGFGGLALAIR-LAAAGIPVTVVEQRDKPGG 35
 
Name Accession Description Interval E-value
CzcO COG2072
Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ...
 20-463 7.80e-161

Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ion transport and metabolism];


Pssm-ID: 441675 [Multi-domain]  Cd Length: 414  Bit Score: 462.80  E-value: 7.80e-161
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390596300  20 HAIQKTKIAIIGAGFGGLAMAIRLLQsQQSDFFILEKSNDVGGTWRENRYPGAACDVQSHMYSLSFAPKTDWSKRYAEAP 99
Cdd:COG2072     2 AATEHVDVVVIGAGQAGLAAAYHLRR-AGIDFVVLEKADDVGGTWRDNRYPGLRLDTPSHLYSLPFFPNWSDDPDFPTGD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390596300 100 EIFDYIQDITNQYQIKNYCKFNHEVTHVQYDEVRHIWTLDFANQPSLEAQFVVFASGPLHIPQIPHIQGIEKFKGKVFHS 179
Cdd:COG2072    81 EILAYLEAYADKFGLRRPIRFGTEVTSARWDEADGRWTVTTDDGETLTARFVVVATGPLSRPKIPDIPGLEDFAGEQLHS 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390596300 180 SQWEHDYSLEGKSVASIGTGGSAIQYIPEIAKDVKQLYVFQRTAAWVIPRDerkysnlskalfkksNLYRQIHRSRLYWS 259
Cdd:COG2072   161 ADWRNPVDLAGKRVLVVGTGASAVQIAPELARVAAHVTVFQRTPPWVLPRP---------------NYDPERGRPANYLG 225

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390596300 260 NESRvVPIVQPQIMkygqKLAEAFIRFQVKDKDLaKKLTPDFVMGCKRILISNKYFPTFNRKNVELVTEGIQEIKENSII 339
Cdd:COG2072   226 LEAP-PALNRRDAR----AWLRRLLRAQVKDPEL-GLLTPDYPPGCKRPLLSTDYYEALRRGNVELVTGGIERITEDGVV 299

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390596300 340 TKDGKERPIDCLIYGTGFVTDPRiYLKHFTCIGRNQielkqawKNGAESYYGIMTKNFPNLFqLVGPNTVLGHNSIIFMI 419
Cdd:COG2072   300 FADGTEHEVDVIVWATGFRADLP-WLAPLDVRGRDG-------RSGPRAYLGVVVPGFPNLF-FLGPNSPSGHSSLTLGA 370

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....
gi 1390596300 420 ESQVNYILQLIDLVEKSGQHAIEIKPEVQDSFNERIQTQLQGTV 463
Cdd:COG2072   371 ERQARYIARLIAHMRRRGAAAIEVRPEAEDAFNARLQRRAARTV 414
FMO-like pfam00743
Flavin-binding monooxygenase-like; This family includes FMO proteins, cyclohexanone ...
 24-357 5.05e-20

Flavin-binding monooxygenase-like; This family includes FMO proteins, cyclohexanone mono-oxygenase and a number of different mono-oxygenases.


Pssm-ID: 395602 [Multi-domain]  Cd Length: 531  Bit Score: 93.30  E-value: 5.05e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390596300  24 KTKIAIIGAGFGGLAmAIRLLQSQQSDFFILEKSNDVGGTWR--ENRYPGAACDVQS-------HMYSLSFAPKTDWSKR 94
Cdd:pfam00743   1 AKKVAVIGAGVSGLA-SIKCCLEEGLEPTCFERSDDIGGLWRftENVEEGRASIYKSvitntskEMSCFSDFPFPEDYPN 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390596300  95 YAEAPEIFDYIQDITNQYQIKNYCKFNHEVTHV----------QYDEVrhiwTLDFANQPSLEAQFVVFASGPLHIPQIP 164
Cdd:pfam00743  80 FMHNSKFLEYFRMFAKEFDLLKYIQFKTTVCSVkkrpdfstsgQWEVV----TEHEGKQESAVFDAVMVCTGHHTNPHLP 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390596300 165 --HIQGIEKFKGKVFHSSQWEHDYSLEGKSVASIGTGGSAIQYIPEIAKDVKQLYVFQRTAAWVIPR---DERKYSNLSK 239
Cdd:pfam00743 156 leSFPGIEKFKGQYFHSRDYKHPEGFTGKRVLVIGIGNSGGDIAVELSHTAAQVFLSTRRGSWVLSRvsdHGYPWDMLFS 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390596300 240 ALFkKSNLYRQIHRSRLYWSNESrvvpivqpqimKYGQKLAEAFIRFQVKDKDLAKKLT-PDFVMGCkriLISNKYFptf 318
Cdd:pfam00743 236 TRF-TSFLRNILPTSISNWLMEK-----------QMNRRFNHENYGLKPKNRALSKEPVvNDDLPNR---ILCGAVK--- 297

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|
gi 1390596300 319 nrknvelVTEGIQEIKENSIITKDG-KERPIDCLIYGTGF 357
Cdd:pfam00743 298 -------VKPNVKEFTETSAIFEDGtVEEDIDVVIFATGY 330
PLN02172 PLN02172
flavin-containing monooxygenase FMO GS-OX
 19-221 1.93e-12

flavin-containing monooxygenase FMO GS-OX


Pssm-ID: 215116 [Multi-domain]  Cd Length: 461  Bit Score: 69.12  E-value: 1.93e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390596300  19 QHAIQKTKIAIIGAGFGGLAMAiRLLQSQQSDFFILEKSNDVGGTWreNRYPGAACD----------VQSHMYS------ 82
Cdd:PLN02172    5 QNPINSQHVAVIGAGAAGLVAA-RELRREGHTVVVFEREKQVGGLW--VYTPKSESDplsldptrsiVHSSVYEslrtnl 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390596300  83 ---------LSFAPKTDW----SKRYAEAPEIFDYIQDITNQYQIKNYCKFNHEVTHVQydEVRHIWTL------DFANQ 143
Cdd:PLN02172   82 precmgyrdFPFVPRFDDesrdSRRYPSHREVLAYLQDFAREFKIEEMVRFETEVVRVE--PVDGKWRVqsknsgGFSKD 159

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1390596300 144 PSLEAqfVVFASGPLHIPQIPHIQGIEKFKGKVFHSSQWEHDYSLEGKSVASIGTGGSAIQYIPEIAKDVKQLYVFQR 221
Cdd:PLN02172  160 EIFDA--VVVCNGHYTEPNVAHIPGIKSWPGKQIHSHNYRVPDPFKNEVVVVIGNFASGADISRDIAKVAKEVHIASR 235
Pyr_redox_3 pfam13738
Pyridine nucleotide-disulphide oxidoreductase;
36-235 4.00e-08

Pyridine nucleotide-disulphide oxidoreductase;


Pssm-ID: 404603 [Multi-domain]  Cd Length: 296  Bit Score: 54.92  E-value: 4.00e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390596300  36 GLAMAIRLLQSQQSDFFILEKSNdVGGTWRenRYPgaacdvqSHM--YSLSF-----------------APKTDWSKRYA 96
Cdd:pfam13738   3 GIGCAIALKKAGLEDYLILEKGN-IGNSFY--RYP-------THMtfFSPSFtsngfgipdlnaispgtSPAFTFNREHP 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390596300  97 EAPEIFDYIQDITNQYQIKnyCKFNHEVTHVQYDEvrHIWTLDfANQPSLEAQFVVFASGPLHIPQIPHiqgiekFKGKV 176
Cdd:pfam13738  73 SGNEYAEYLRRVADHFELP--INLFEEVTSVKKED--DGFVVT-TSKGTYQARYVIIATGEFDFPNKLG------VPELP 141

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1390596300 177 FHSSQWEHDYSLEGKSVASIGTGGSAIQYIPEIAKDVKQLYVFQRTAAWVIPRDERKYS 235
Cdd:pfam13738 142 KHYSYVKDFHPYAGQKVVVIGGYNSAVDAALELVRKGARVTVLYRGSEWEDRDSDPSYS 200
NAD_binding_8 pfam13450
NAD(P)-binding Rossmann-like domain;
29-79 5.72e-08

NAD(P)-binding Rossmann-like domain;


Pssm-ID: 433218 [Multi-domain]  Cd Length: 67  Bit Score: 49.45  E-value: 5.72e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1390596300  29 IIGAGFGGLAMAiRLLQSQQSDFFILEKSNDVGGTWRENRYPGAACDVQSH 79
Cdd:pfam13450   1 IVGAGLAGLVAA-ALLAKRGFRVLVLEKRDRLGGNAYSYRVPGYVFDYGAH 50
Lys_Orn_oxgnase pfam13434
L-lysine 6-monooxygenase/L-ornithine 5-monooxygenase; This is a family of Rossmann fold ...
 110-202 1.46e-06

L-lysine 6-monooxygenase/L-ornithine 5-monooxygenase; This is a family of Rossmann fold oxidoreductases that catalyze NADPH-dependent hydroxylation and are involved in siderophore biosynthesis. This family includes L-ornithine 5-monooxygenase, which catalyzes the hydroxylation of L-ornithine at the N5 position, and L-lysine 6-monooxygenase, which catalyzes the hydroxylation of lysine at the N6 position (EC:1.14.13.59).


Pssm-ID: 433204 [Multi-domain]  Cd Length: 338  Bit Score: 50.28  E-value: 1.46e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390596300 110 NQY------QIKNYCKFNHEVTHVQYDEVRH-----IWTLDFANQP-SLEAQFVVFASGPlhIPQIPhiqgiEKFKGK-- 175
Cdd:pfam13434  98 NDYlqwaasHLPNRLRFGQEVESVEPDAERGepllrVRVRDADGEEtTFLARNLVLGTGG--EPYIP-----ECARGGer 170

                          90       100
                  ....*....|....*....|....*....
gi 1390596300 176 VFHSSQW--EHDYSLEGKSVASIGTGGSA 202
Cdd:pfam13434 171 VFHSSEYleRIDRLAAKKRIAVVGSGQSA 199
HemY COG1232
Protoporphyrinogen oxidase HemY/PPOX [Coenzyme transport and metabolism]; Protoporphyrinogen ...
 24-70 2.10e-04

Protoporphyrinogen oxidase HemY/PPOX [Coenzyme transport and metabolism]; Protoporphyrinogen oxidase HemY/PPOX is part of the Pathway/BioSystem: Heme biosynthesis


Pssm-ID: 440845 [Multi-domain]  Cd Length: 443  Bit Score: 43.67  E-value: 2.10e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1390596300  24 KTKIAIIGAGFGGLAMAiRLLQSQQSDFFILEKSNDVGG---TWRENRYP 70
Cdd:COG1232     1 MKRVAVIGGGIAGLTAA-YRLAKAGHEVTVLEASDRVGGlirTVEVDGFR 49
COG1233 COG1233
Phytoene dehydrogenase-related protein [Secondary metabolites biosynthesis, transport and ...
 23-83 3.08e-04

Phytoene dehydrogenase-related protein [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 440846 [Multi-domain]  Cd Length: 491  Bit Score: 43.30  E-value: 3.08e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1390596300  23 QKTKIAIIGAGFGGLAMAIRL-------LqsqqsdffILEKSNDVGG---TWREnryPGAACDVQSHMYSL 83
Cdd:COG1233     2 MMYDVVVIGAGIGGLAAAALLaragyrvT--------VLEKNDTPGGrarTFER---PGFRFDVGPSVLTM 61
NAD_binding_9 pfam13454
FAD-NAD(P)-binding;
28-65 7.06e-04

FAD-NAD(P)-binding;


Pssm-ID: 433222 [Multi-domain]  Cd Length: 155  Bit Score: 40.34  E-value: 7.06e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1390596300  28 AIIGAGFGGLAMAIRLLQSQQS---DFFILEKSND-VGGTWR 65
Cdd:pfam13454   1 AIVGGGPSGLALLERLLARAPKrplEITLFDPSPPgAGGVYR 42
YdhS COG4529
Uncharacterized NAD(P)/FAD-binding protein YdhS [General function prediction only];
23-203 9.99e-04

Uncharacterized NAD(P)/FAD-binding protein YdhS [General function prediction only];


Pssm-ID: 443597 [Multi-domain]  Cd Length: 466  Bit Score: 41.48  E-value: 9.99e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390596300  23 QKTKIAIIGAGFGGLAMAIRLLQSQQSDF--FILEKSNDVG-----GT--------------------------WRENRY 69
Cdd:COG4529     4 ARKRIAIIGGGASGTALAIHLLRRAPEPLriTLFEPRPELGrgvaySTdspehllnvpagrmsafpddpdhflrWLRENG 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390596300  70 PGAACDVQSHmyslSFAPktdwskRYaeapeIF-DYIQDITNQY--QIKNYCKFNH---EVTHVQYDEVRhiWTLDFANQ 143
Cdd:COG4529    84 ARAAPAIDPD----AFVP------RR-----LFgEYLRERLAEAlaRAPAGVRLRHiraEVVDLERDDGG--YRVTLADG 146

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1390596300 144 PSLEAQFVVFASGplHIPqiPHIQGIEKFKGKVFHSSQWEHDySLE----GKSVASIGTGGSAI 203
Cdd:COG4529   147 ETLRADAVVLATG--HPP--PAPPPGLAAGSPRYIADPWPPG-ALArippDARVLIIGTGLTAI 205
PRK07233 PRK07233
hypothetical protein; Provisional
 26-70 1.39e-03

hypothetical protein; Provisional


Pssm-ID: 235977 [Multi-domain]  Cd Length: 434  Bit Score: 41.03  E-value: 1.39e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1390596300  26 KIAIIGAGFGGLAMAIRLLQsQQSDFFILEKSNDVGG---TWRENRYP 70
Cdd:PRK07233    1 KIAIVGGGIAGLAAAYRLAK-RGHEVTVFEADDQLGGlaaSFEFGGLP 47
mnmC PRK01747
bifunctional tRNA (5-methylaminomethyl-2-thiouridine)(34)-methyltransferase MnmD/FAD-dependent ...
 118-156 2.21e-03

bifunctional tRNA (5-methylaminomethyl-2-thiouridine)(34)-methyltransferase MnmD/FAD-dependent 5-carboxymethylaminomethyl-2-thiouridine(34) oxidoreductase MnmC;


Pssm-ID: 234978 [Multi-domain]  Cd Length: 662  Bit Score: 40.60  E-value: 2.21e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1390596300 118 CKFNHEVThvQYDEVRHIWTLDFANQPSLEAQFVVFASG 156
Cdd:PRK01747  424 IHFGHEVA--RLEREDDGWQLDFAGGTLASAPVVVLANG 460
crtI_fam TIGR02734
phytoene desaturase; Phytoene is converted to lycopene by desaturation at four (two ...
 29-62 3.93e-03

phytoene desaturase; Phytoene is converted to lycopene by desaturation at four (two symmetrical pairs of) sites. This is achieved by two enzymes (crtP and crtQ) in cyanobacteria (Gloeobacter being an exception) and plants, but by a single enzyme in most other bacteria and in fungi. This single enzyme is called the bacterial-type phytoene desaturase, or CrtI. Most members of this family, part of the larger pfam01593, which also contains amino oxidases, are CrtI itself; it is likely that all members act on either phytoene or on related compounds such as dehydrosqualene, for carotenoid biosynthesis. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other]


Pssm-ID: 274273 [Multi-domain]  Cd Length: 495  Bit Score: 39.95  E-value: 3.93e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1390596300  29 IIGAGFGGLAMAIRlLQSQQSDFFILEKSNDVGG 62
Cdd:TIGR02734   3 VIGAGFGGLALAIR-LAAAGIPVTVVEQRDKPGG 35
COG3380 COG3380
Predicted NAD/FAD-dependent oxidoreductase [General function prediction only];
24-62 4.59e-03

Predicted NAD/FAD-dependent oxidoreductase [General function prediction only];


Pssm-ID: 442607 [Multi-domain]  Cd Length: 331  Bit Score: 39.09  E-value: 4.59e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1390596300  24 KTKIAIIGAGFGGLAMAiRLLQSQQSDFFILEKSNDVGG 62
Cdd:COG3380     3 MPDIAIIGAGIAGLAAA-RALQDAGHEVTVFEKSRGVGG 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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