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Conserved domains on  [gi|1392532696|ref|WP_109665246|]
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mechanosensitive ion channel domain-containing protein [Flagellimonas aquimarina]

Protein Classification

mechanosensitive ion channel family protein( domain architecture ID 1903239)

mechanosensitive ion channel family protein is a conductance mechanosensitive channel that opens in response to stretch forces in the membrane lipid bilayer, and may be anion or cation selective, similar to Oleiphilus sp. potassium transporter KefA

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MscK super family cl43825
Small-conductance mechanosensitive channel MscK [Cell wall/membrane/envelope biogenesis];
114-271 7.45e-14

Small-conductance mechanosensitive channel MscK [Cell wall/membrane/envelope biogenesis];


The actual alignment was detected with superfamily member COG3264:

Pssm-ID: 442495 [Multi-domain]  Cd Length: 281  Bit Score: 69.84  E-value: 7.45e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1392532696 114 IGNLLRYLPRLFSALALMMIGLYIGNFIKTTVKKLF---DSLEFGGSNLVSNMLFYIIVIFISITALNQAGIDTTiitnN 190
Cdd:COG3264    13 IGGISISLPNLLLALLILVVTYLLARLLSRLLERRLlrrTRLDPGLRYLISKLIRYLIIVLGLLIALSALGIDLT----A 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1392532696 191 ITLILGsfllAFAIGLGLGSRDIITDLLRSF--YTRRTYAVGDKVVIGKNEGTIEAIENNTLTLVTKTGKFV-IPIKDVV 267
Cdd:COG3264    89 LAALAG----ALGVGIGFGLQDIVSNFISGLilLFERPFRVGDWIEIGGTEGTVEEIGLRSTRIRTFDGEEViIPNSELI 164


                  ....
gi 1392532696 268 SKKV 271
Cdd:COG3264   165 TNPV 168
 
Name Accession Description Interval E-value
MscK COG3264
Small-conductance mechanosensitive channel MscK [Cell wall/membrane/envelope biogenesis];
114-271 7.45e-14

Small-conductance mechanosensitive channel MscK [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442495 [Multi-domain]  Cd Length: 281  Bit Score: 69.84  E-value: 7.45e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1392532696 114 IGNLLRYLPRLFSALALMMIGLYIGNFIKTTVKKLF---DSLEFGGSNLVSNMLFYIIVIFISITALNQAGIDTTiitnN 190
Cdd:COG3264    13 IGGISISLPNLLLALLILVVTYLLARLLSRLLERRLlrrTRLDPGLRYLISKLIRYLIIVLGLLIALSALGIDLT----A 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1392532696 191 ITLILGsfllAFAIGLGLGSRDIITDLLRSF--YTRRTYAVGDKVVIGKNEGTIEAIENNTLTLVTKTGKFV-IPIKDVV 267
Cdd:COG3264    89 LAALAG----ALGVGIGFGLQDIVSNFISGLilLFERPFRVGDWIEIGGTEGTVEEIGLRSTRIRTFDGEEViIPNSELI 164


                  ....
gi 1392532696 268 SKKV 271
Cdd:COG3264   165 TNPV 168
PRK10334 PRK10334
small-conductance mechanosensitive channel MscS;
117-261 2.63e-04

small-conductance mechanosensitive channel MscS;


Pssm-ID: 182386 [Multi-domain]  Cd Length: 286  Bit Score: 41.83  E-value: 2.63e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1392532696 117 LLRYLPRLFSALALMMIGLYIGNFIKTTVKKLFDSLEFGGS--NLVSNMLFYIIVIFISITALNQAGIDTTiitnNITLI 194
Cdd:PRK10334   24 LLSYAVNIVAALAIIIVGLIIARMISNAVNRLMISRKIDATvaDFLSALVRYGIIAFTLIAALGRVGVQTA----SVIAV 99

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1392532696 195 LGSFLLAFAIGLGLGSRDIITDLLrsFYTRRTYAVGDKVVIGKNEGTIEAIENNTLTLVTKTGKFVI 261
Cdd:PRK10334  100 LGAAGLAVGLALQGSLSNLAAGVL--LVMFRPFRAGEYVDLGGVAGTVLSVQIFSTTMRTADGKIIV 164
MS_channel pfam00924
Mechanosensitive ion channel; Two members of this protein family: Swiss:Q57634 and Swiss: ...
 161-272 5.32e-04

Mechanosensitive ion channel; Two members of this protein family: Swiss:Q57634 and Swiss:Q58543 of M. jannaschii have been functionally characterized. Both proteins form mechanosensitive (MS) ion channels upon reconstitution into liposomes and functional examination by the patch-clamp technique. Therefore this family are likely to also be MS channel proteins.


Pssm-ID: 459999 [Multi-domain]  Cd Length: 203  Bit Score: 40.28  E-value: 5.32e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1392532696 161 SNMLFYIIVIFISITALNQAGIDTTiitnNITLILGsfllAFAIGLGLGSRDIITDLLRSF--YTRRTYAVGDKVVIGKN 238
Cdd:pfam00924   1 KKILKYLIIVVGILIVLSYLGVNVS----ALLAGLG----ALGLALGFALQDLVSNLVSGIiiLFEKPFKIGDWIEIGDI 72

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1392532696 239 EGTIEAIENNTLTLVTKTGK-FVIPIKDVVSKKVE 272
Cdd:pfam00924  73 EGTVEDIGLRTTTIRTFDGRlVTIPNSSILTSNII 107
 
Name Accession Description Interval E-value
MscK COG3264
Small-conductance mechanosensitive channel MscK [Cell wall/membrane/envelope biogenesis];
114-271 7.45e-14

Small-conductance mechanosensitive channel MscK [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442495 [Multi-domain]  Cd Length: 281  Bit Score: 69.84  E-value: 7.45e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1392532696 114 IGNLLRYLPRLFSALALMMIGLYIGNFIKTTVKKLF---DSLEFGGSNLVSNMLFYIIVIFISITALNQAGIDTTiitnN 190
Cdd:COG3264    13 IGGISISLPNLLLALLILVVTYLLARLLSRLLERRLlrrTRLDPGLRYLISKLIRYLIIVLGLLIALSALGIDLT----A 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1392532696 191 ITLILGsfllAFAIGLGLGSRDIITDLLRSF--YTRRTYAVGDKVVIGKNEGTIEAIENNTLTLVTKTGKFV-IPIKDVV 267
Cdd:COG3264    89 LAALAG----ALGVGIGFGLQDIVSNFISGLilLFERPFRVGDWIEIGGTEGTVEEIGLRSTRIRTFDGEEViIPNSELI 164


                  ....
gi 1392532696 268 SKKV 271
Cdd:COG3264   165 TNPV 168
MscS COG0668
Small-conductance mechanosensitive channel [Cell wall/membrane/envelope biogenesis];
104-272 1.60e-10

Small-conductance mechanosensitive channel [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440432 [Multi-domain]  Cd Length: 276  Bit Score: 60.28  E-value: 1.60e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1392532696 104 ILSWEIISTEIGNLLRYLPRLFSALALMMIGLYIGNFIKTTVKKLFDSLEFGGS--NLVSNMLFYIIVIFISITALNQAG 181
Cdd:COG0668     7 WSLLGLLLLLGELLLALLPKLLLALLILLIGWLLIRLLRRLIRRLLRRARRDRTllPLLRNILKILIVIIAILLILSILG 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1392532696 182 IDTTiitnniTLILGsfLLAFAIGLGLGSRDIITDLLRSF--YTRRTYAVGDKVVIGKNEGTIEAIENNTLTLVTKTGKF 259
Cdd:COG0668    87 VNIT------SLLAG--LGAAGLAIGLAAQDLLSNFIAGIfiLLERPFRVGDWIEVGGVEGTVEEIGLRSTRLRTLDGRL 158

                         170
                  ....*....|....
gi 1392532696 260 V-IPIKDVVSKKVE 272
Cdd:COG0668   159 VtIPNSKILSSPIT 172
PRK10334 PRK10334
small-conductance mechanosensitive channel MscS;
117-261 2.63e-04

small-conductance mechanosensitive channel MscS;


Pssm-ID: 182386 [Multi-domain]  Cd Length: 286  Bit Score: 41.83  E-value: 2.63e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1392532696 117 LLRYLPRLFSALALMMIGLYIGNFIKTTVKKLFDSLEFGGS--NLVSNMLFYIIVIFISITALNQAGIDTTiitnNITLI 194
Cdd:PRK10334   24 LLSYAVNIVAALAIIIVGLIIARMISNAVNRLMISRKIDATvaDFLSALVRYGIIAFTLIAALGRVGVQTA----SVIAV 99

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1392532696 195 LGSFLLAFAIGLGLGSRDIITDLLrsFYTRRTYAVGDKVVIGKNEGTIEAIENNTLTLVTKTGKFVI 261
Cdd:PRK10334  100 LGAAGLAVGLALQGSLSNLAAGVL--LVMFRPFRAGEYVDLGGVAGTVLSVQIFSTTMRTADGKIIV 164
MS_channel pfam00924
Mechanosensitive ion channel; Two members of this protein family: Swiss:Q57634 and Swiss: ...
 161-272 5.32e-04

Mechanosensitive ion channel; Two members of this protein family: Swiss:Q57634 and Swiss:Q58543 of M. jannaschii have been functionally characterized. Both proteins form mechanosensitive (MS) ion channels upon reconstitution into liposomes and functional examination by the patch-clamp technique. Therefore this family are likely to also be MS channel proteins.


Pssm-ID: 459999 [Multi-domain]  Cd Length: 203  Bit Score: 40.28  E-value: 5.32e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1392532696 161 SNMLFYIIVIFISITALNQAGIDTTiitnNITLILGsfllAFAIGLGLGSRDIITDLLRSF--YTRRTYAVGDKVVIGKN 238
Cdd:pfam00924   1 KKILKYLIIVVGILIVLSYLGVNVS----ALLAGLG----ALGLALGFALQDLVSNLVSGIiiLFEKPFKIGDWIEIGDI 72

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1392532696 239 EGTIEAIENNTLTLVTKTGK-FVIPIKDVVSKKVE 272
Cdd:pfam00924  73 EGTVEDIGLRTTTIRTFDGRlVTIPNSSILTSNII 107
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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