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Conserved domains on  [gi|1394421523|ref|WP_110014419|]
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MULTISPECIES: phosphatase PAP2 family protein [Idiomarina]

Protein Classification

phosphatase PAP2 family protein( domain architecture ID 10107962)

phosphatase PAP2 family protein may be a histidine phosphatase that catalyzes the dephosphorylation of phospholipids, similar to Mycobacterium tuberculosis decaprenylphosphoryl-5-phosphoribose phosphatase

CATH:  1.20.144.10
EC:  3.1.3.-
Gene Ontology:  GO:0008610|GO:0042577|GO:0046839
PubMed:  9122162|12447906|9041652|9260289
SCOP:  3001110|4001226

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PAP2_like cd01610
PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, ...
 90-211 2.32e-13

PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid phosphatase, vanadium chloroperoxidases, vanadium bromoperoxidases, and several other mostly uncharacterized subfamilies. Several members of this superfamily have been predicted to be transmembrane proteins.


:

Pssm-ID: 238813 [Multi-domain]  Cd Length: 122  Bit Score: 65.17  E-value: 2.32e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394421523  90 RMWAAMFGAVPLACALSHLGKSFFAIPRPAAVLEHHQFTIIGDTLTAYTSFPSGHTitiftAISAMVFVLLREAKISEKH 169
Cdd:cd01610     3 LLALLLLLALLAGLLLTGVLKYLFGRPRPYFLLRCGPDGDPLLLTEGGYSFPSGHA-----AFAFALALFLALLLPRRLL 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1394421523 170 KTYWIYLSLMVATVVAISRVAVGAHWPADLASGAIIGTVSGL 211
Cdd:cd01610    78 RLLLGLLLLLLALLVGLSRVYLGVHYPSDVLAGALLGILVAL 119
 
Name Accession Description Interval E-value
PAP2_like cd01610
PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, ...
 90-211 2.32e-13

PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid phosphatase, vanadium chloroperoxidases, vanadium bromoperoxidases, and several other mostly uncharacterized subfamilies. Several members of this superfamily have been predicted to be transmembrane proteins.


Pssm-ID: 238813 [Multi-domain]  Cd Length: 122  Bit Score: 65.17  E-value: 2.32e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394421523  90 RMWAAMFGAVPLACALSHLGKSFFAIPRPAAVLEHHQFTIIGDTLTAYTSFPSGHTitiftAISAMVFVLLREAKISEKH 169
Cdd:cd01610     3 LLALLLLLALLAGLLLTGVLKYLFGRPRPYFLLRCGPDGDPLLLTEGGYSFPSGHA-----AFAFALALFLALLLPRRLL 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1394421523 170 KTYWIYLSLMVATVVAISRVAVGAHWPADLASGAIIGTVSGL 211
Cdd:cd01610    78 RLLLGLLLLLLALLVGLSRVYLGVHYPSDVLAGALLGILVAL 119
PgpB COG0671
Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; ...
 22-218 8.69e-13

Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; Membrane-associated phospholipid phosphatase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 440435 [Multi-domain]  Cd Length: 189  Bit Score: 65.45  E-value: 8.69e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394421523  22 ISFICFMSAIMVSMALNKDAYIASQKDIFSFSNNALQILPSEIWHNITYLGDALILIPLLSFICLVNTRMWAAMFGAVPL 101
Cdd:COG0671     1 LLLALLLALLLLLLLLADLLALALLALLLLLALLLLLLLLLALLLILLLLLLLLLLLLLLLLLLLRLLALLLLLLLLAAL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394421523 102 ACALSHLG----KSFFAIPRPAAVLEHHQFTIIGDTLtaytSFPSGHTITIFTAISAMVFVLLReakisekhkTYWIYLS 177
Cdd:COG0671    81 LLLLLLLLllllKYLFGRPRPFVVPDLELLLGTAGGY----SFPSGHAAAAFALALVLALLLPR---------RWLAALL 147

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 1394421523 178 LMVATVVAISRVAVGAHWPADLASGAIIGTVSGLSGEYLSR 218
Cdd:COG0671   148 LALALLVGLSRVYLGVHYPSDVLAGALLGLAIALLLLALLR 188
PAP2 pfam01569
PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), ...
 104-211 1.66e-11

PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), Glucose-6-phosphatase EC:3.1.3.9, Phosphatidylglycerophosphatase B EC:3.1.3.27 and bacterial acid phosphatase EC:3.1.3.2. The family also includes a variety of haloperoxidases that function by oxidising halides in the presence of hydrogen peroxide to form the corresponding hypohalous acids.


Pssm-ID: 426329 [Multi-domain]  Cd Length: 124  Bit Score: 60.13  E-value: 1.66e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394421523 104 ALSHLGKSFFAIPRPAAVLEHHQFTIIGDTLTAYT-SFPSGHTITIFTAISAMVFvLLREAKISEKHKTYWIYLSLmvAT 182
Cdd:pfam01569  11 LLSSVLKDYFGRPRPFFLLLEGGLVPAPSTLPGLGySFPSGHSATAFALALLLAL-LLRRLRKIVRVLLALLLLVL--AL 87

                          90       100
                  ....*....|....*....|....*....
gi 1394421523 183 VVAISRVAVGAHWPADLASGAIIGTVSGL 211
Cdd:pfam01569  88 LVGLSRLYLGVHFPSDVLAGALIGILLAL 116
acidPPc smart00014
Acid phosphatase homologues;
110-211 1.50e-10

Acid phosphatase homologues;


Pssm-ID: 214471 [Multi-domain]  Cd Length: 116  Bit Score: 57.36  E-value: 1.50e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394421523  110 KSFFAIPRPAAVLEHHQFTIIGD--TLTAYTSFPSGHTITIFTAISAMVFVLLREAkisekHKTYWIYLSLMVATVVAIS 187
Cdd:smart00014  15 KNYFGRPRPFFLSIGDACCTPNFllTLEAGYSFPSGHTAFAFAFALFLLLYLPARA-----GRKLLIFLLLLLALVVGFS 89

                           90       100
                   ....*....|....*....|....
gi 1394421523  188 RVAVGAHWPADLASGAIIGTVSGL 211
Cdd:smart00014  90 RVYLGAHWPSDVLAGSLLGILIAA 113
PRK11837 PRK11837
undecaprenyl pyrophosphate phosphatase; Provisional
 138-212 2.11e-04

undecaprenyl pyrophosphate phosphatase; Provisional


Pssm-ID: 183335  Cd Length: 202  Bit Score: 41.54  E-value: 2.11e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1394421523 138 TSFPSGHTITIFTAISAMVFVllreakisekHKTyWIYLSLM-VATVVAISRVAVGAHWPADLASGAIIGTVSGLS 212
Cdd:PRK11837  103 DSFPSDHGTVIFTFALAFLFW----------HRL-WSGSLLMaIAVAIAWSRVYLGVHWPLDMLGALLVGMIGCLS 167
 
Name Accession Description Interval E-value
PAP2_like cd01610
PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, ...
 90-211 2.32e-13

PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid phosphatase, vanadium chloroperoxidases, vanadium bromoperoxidases, and several other mostly uncharacterized subfamilies. Several members of this superfamily have been predicted to be transmembrane proteins.


Pssm-ID: 238813 [Multi-domain]  Cd Length: 122  Bit Score: 65.17  E-value: 2.32e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394421523  90 RMWAAMFGAVPLACALSHLGKSFFAIPRPAAVLEHHQFTIIGDTLTAYTSFPSGHTitiftAISAMVFVLLREAKISEKH 169
Cdd:cd01610     3 LLALLLLLALLAGLLLTGVLKYLFGRPRPYFLLRCGPDGDPLLLTEGGYSFPSGHA-----AFAFALALFLALLLPRRLL 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1394421523 170 KTYWIYLSLMVATVVAISRVAVGAHWPADLASGAIIGTVSGL 211
Cdd:cd01610    78 RLLLGLLLLLLALLVGLSRVYLGVHYPSDVLAGALLGILVAL 119
PgpB COG0671
Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; ...
 22-218 8.69e-13

Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; Membrane-associated phospholipid phosphatase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 440435 [Multi-domain]  Cd Length: 189  Bit Score: 65.45  E-value: 8.69e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394421523  22 ISFICFMSAIMVSMALNKDAYIASQKDIFSFSNNALQILPSEIWHNITYLGDALILIPLLSFICLVNTRMWAAMFGAVPL 101
Cdd:COG0671     1 LLLALLLALLLLLLLLADLLALALLALLLLLALLLLLLLLLALLLILLLLLLLLLLLLLLLLLLLRLLALLLLLLLLAAL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394421523 102 ACALSHLG----KSFFAIPRPAAVLEHHQFTIIGDTLtaytSFPSGHTITIFTAISAMVFVLLReakisekhkTYWIYLS 177
Cdd:COG0671    81 LLLLLLLLllllKYLFGRPRPFVVPDLELLLGTAGGY----SFPSGHAAAAFALALVLALLLPR---------RWLAALL 147

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 1394421523 178 LMVATVVAISRVAVGAHWPADLASGAIIGTVSGLSGEYLSR 218
Cdd:COG0671   148 LALALLVGLSRVYLGVHYPSDVLAGALLGLAIALLLLALLR 188
PAP2_like_2 cd03392
PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
 63-208 1.57e-11

PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


Pssm-ID: 239486  Cd Length: 182  Bit Score: 61.86  E-value: 1.57e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394421523  63 EIWHNITYLGDALILIPLLSFICLVNTRM---WAAMFGAVPLAC--ALSHLGKSFFAIPRPAAVLEHHQFTiigdtltay 137
Cdd:cd03392    30 AFMTAITFLGSPAVLLIIVLLLALLLLLKrrrRAALFLLLALLGggALNTLLKLLVQRPRPPLHLLVPEGG--------- 100

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1394421523 138 TSFPSGHTITIFTAISAMVFVLLREAKiSEKHKTYWIYLSLMVATVVAISRVAVGAHWPADLASGAIIGTV 208
Cdd:cd03392   101 YSFPSGHAMGATVLYGFLAYLLARRLP-RRRVRILLLILAAILILLVGLSRLYLGVHYPSDVLAGWLLGLA 170
PAP2 pfam01569
PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), ...
 104-211 1.66e-11

PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), Glucose-6-phosphatase EC:3.1.3.9, Phosphatidylglycerophosphatase B EC:3.1.3.27 and bacterial acid phosphatase EC:3.1.3.2. The family also includes a variety of haloperoxidases that function by oxidising halides in the presence of hydrogen peroxide to form the corresponding hypohalous acids.


Pssm-ID: 426329 [Multi-domain]  Cd Length: 124  Bit Score: 60.13  E-value: 1.66e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394421523 104 ALSHLGKSFFAIPRPAAVLEHHQFTIIGDTLTAYT-SFPSGHTITIFTAISAMVFvLLREAKISEKHKTYWIYLSLmvAT 182
Cdd:pfam01569  11 LLSSVLKDYFGRPRPFFLLLEGGLVPAPSTLPGLGySFPSGHSATAFALALLLAL-LLRRLRKIVRVLLALLLLVL--AL 87

                          90       100
                  ....*....|....*....|....*....
gi 1394421523 183 VVAISRVAVGAHWPADLASGAIIGTVSGL 211
Cdd:pfam01569  88 LVGLSRLYLGVHFPSDVLAGALIGILLAL 116
acidPPc smart00014
Acid phosphatase homologues;
110-211 1.50e-10

Acid phosphatase homologues;


Pssm-ID: 214471 [Multi-domain]  Cd Length: 116  Bit Score: 57.36  E-value: 1.50e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394421523  110 KSFFAIPRPAAVLEHHQFTIIGD--TLTAYTSFPSGHTITIFTAISAMVFVLLREAkisekHKTYWIYLSLMVATVVAIS 187
Cdd:smart00014  15 KNYFGRPRPFFLSIGDACCTPNFllTLEAGYSFPSGHTAFAFAFALFLLLYLPARA-----GRKLLIFLLLLLALVVGFS 89

                           90       100
                   ....*....|....*....|....
gi 1394421523  188 RVAVGAHWPADLASGAIIGTVSGL 211
Cdd:smart00014  90 RVYLGAHWPSDVLAGSLLGILIAA 113
PAP2_like_5 cd03394
PAP2_like_5 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
 92-210 6.61e-10

PAP2_like_5 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


Pssm-ID: 239488 [Multi-domain]  Cd Length: 106  Bit Score: 55.41  E-value: 6.61e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394421523  92 WAAMFGAVpLACALSHLGKSFFAIPRPaavlehhqftiiGDTLTAYTSFPSGHTITIFTAISAMVFVLlreakiseKHKT 171
Cdd:cd03394     6 LILAEAAA-LTAAVTEGLKFAVGRARP------------DGSNNGYRSFPSGHTASAFAAATFLQYRY--------GWRW 64

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1394421523 172 YWIYLSLmVATVVAISRVAVGAHWPADLASGAIIGTVSG 210
Cdd:cd03394    65 YGIPAYA-LASLVGASRVVANRHWLSDVLAGAAIGILVG 102
PAP2_like_4 cd03395
PAP2_like_4 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
 76-219 1.81e-09

PAP2_like_4 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


Pssm-ID: 239489  Cd Length: 177  Bit Score: 55.73  E-value: 1.81e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394421523  76 ILIPLLSFICLVNTRMWAAMFGAVPLACAL-----SHLGKSFFAIPRPAAVLEHHQFTIIGDTLTAYtSFPSGHTITIFT 150
Cdd:cd03395    38 IFLLLALFILFRKGPIGLLILLLVLLAVGFadqlaSGFLKPLVARLRPCNALDGVRLVVLGDQGGSY-SFASSHAANSFA 116

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1394421523 151 AISAMVFVLlreakisekHKTYWIYLSLMVATVVAISRVAVGAHWPADLASGAIIGTVSGLSGEYLSRY 219
Cdd:cd03395   117 LALFIWLFF---------RRGLFSPVLLLWALLVGYSRVYVGVHYPGDVIAGALIGIISGLLFYLLFSW 176
PAP2_BcrC_like cd03385
PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as ...
 116-212 5.15e-09

PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from Bacillus subtilis posesses undecaprenyl pyrophosphate (UPP) phospatase activity, and it is hypothesized that it competes with bacitracin for UPP, increasing the cell's resistance to bacitracin.


Pssm-ID: 239480  Cd Length: 144  Bit Score: 53.80  E-value: 5.15e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394421523 116 PRPAAVLEHHQFTiigdTLTAYTSFPSGHTITIFTAISAMVFVllreakisekHKTYWIYLSLMVATVVAISRVAVGAHW 195
Cdd:cd03385    59 PRPFVVGLGHNLL----PHAADSSFPSDHTTLFFSIAFSLLLR----------RRKWAGWILLILALLVAWSRIYLGVHY 124

                          90
                  ....*....|....*..
gi 1394421523 196 PADLASGAIIGTVSGLS 212
Cdd:cd03385   125 PLDMLGAALVAVLSALL 141
PAP2_lipid_A_1_phosphatase cd03389
PAP2_like proteins, Lipid A 1-phosphatase subfamily. Lipid A 1-phosphatase, or LpxE from ...
 89-211 6.15e-09

PAP2_like proteins, Lipid A 1-phosphatase subfamily. Lipid A 1-phosphatase, or LpxE from Francisella novicida selectively dephosphorylates lipid A at the 1-position. Lipid A is the membrane-anchor component of lipopolysaccharides (LPS), the major constituents of the outer membrane in many gram-negative bacteria.


Pssm-ID: 239483  Cd Length: 186  Bit Score: 54.63  E-value: 6.15e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394421523  89 TRMWAAMFGAVPLACALSHLGKSFFAIPRPAAVLEH-----HQFTIIgdtlTAYTSFPSGHTITIFTAISAMVFVLLRea 163
Cdd:cd03389    68 AWAGLFLFATVALSGILVNLLKFIIGRARPKLLFDDglygfDPFHAD----YAFTSFPSGHSATAGAAAAALALLFPR-- 141

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1394421523 164 kisekhktyWIYLSLMVATVVAISRVAVGAHWPADLASGAIIGTVSGL 211
Cdd:cd03389   142 ---------YRWAFILLALLIAFSRVIVGAHYPSDVIAGSLLGAVTAL 180
PAP2_like_1 cd03380
PAP2_like_1 proteins, a sub-family of PAP2, containing bacterial acid phosphatase, vanadium ...
 110-207 6.30e-07

PAP2_like_1 proteins, a sub-family of PAP2, containing bacterial acid phosphatase, vanadium chloroperoxidases and vanadium bromoperoxidases.


Pssm-ID: 239475  Cd Length: 209  Bit Score: 48.97  E-value: 6.30e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394421523 110 KSFFAIPRPaavlehhqFTIIGDTLTAYT----------SFPSGHTitiftAISAMVFVLLREAkISEKHKTYwiylsLM 179
Cdd:cd03380   113 KYHYNRPRP--------FVAIRLQWLPICtpeegtpkhpSYPSGHA-----TFGGAAALVLAEL-FPERAAEL-----LA 173

                          90       100
                  ....*....|....*....|....*...
gi 1394421523 180 VATVVAISRVAVGAHWPADLASGAIIGT 207
Cdd:cd03380   174 RAAEAGNSRVVAGVHWPSDVEAGRILGE 201
PAP2_containing_1_like cd03390
PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. ...
 112-211 1.04e-06

PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. Most likely membrane-associated phosphatidic acid phosphatases. Plant members of this group are constitutively expressed in many tissues and exhibit both diacylglycerol pyrophosphate phosphatase activity as well as phosphatidate (PA) phosphatase activity, they may have a more generic housekeeping role in lipid metabolism.


Pssm-ID: 239484 [Multi-domain]  Cd Length: 193  Bit Score: 47.98  E-value: 1.04e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394421523 112 FFA--IPRPAAVLEHHQFTIIGDT------LTAYTSFPSGHTITIFTAISAMVFVLLREAKISEKHKTYWIYLS----LM 179
Cdd:cd03390    76 FLArcFPDGGTPSDTLVGIDICCTgdpgvlKEGRKSFPSGHSSFAFAGLGFLSLYLAGKLHIFDPRGSSWRLLLallpLL 155

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1394421523 180 VATVVAISRVAVGAHWPADLASGAIIGTVSGL 211
Cdd:cd03390   156 LAILVAVSRTRDYRHHFSDVIAGSLIGLIIAY 187
PAP2_containing_2_like cd03391
PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_2. ...
 68-214 3.55e-05

PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_2. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to eukaryota, lacks functional characterization and may act as a membrane-associated phosphatidic acid phosphatase.


Pssm-ID: 239485 [Multi-domain]  Cd Length: 159  Bit Score: 43.08  E-value: 3.55e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394421523  68 ITYLGDALILIPL-LSFICLVNTRMWAAM-----FGAVpLACALSHLGKSFFAIPRPAAVLEHHQFTIIGDTLtaytSFP 141
Cdd:cd03391    20 LELSGHGIPWLAGtISCLWISSSPAGQEVlvnllLGLL-LDIITVAILKALVRRRRPAYNSPDMLDYVAVDKY----SFP 94

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1394421523 142 SGHTitiftaiSAMVFVLLREAKISEKHKTYWIYLSLMvATVVAISRVAVGAHWPADLASGAIIGTVSGLSGE 214
Cdd:cd03391    95 SGHA-------SRAAFVARFLLNHLVLAVPLRVLLVLW-ATVVGISRVLLGRHHVLDVLAGAFLGYLEALLVE 159
PAP2_like_6 cd03396
PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
 74-195 5.76e-05

PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


Pssm-ID: 239490  Cd Length: 197  Bit Score: 43.06  E-value: 5.76e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394421523  74 ALILIPLLSFICLVNTRMWAAMFGAVPLACALS----HLGKSFFAIPRPAAVLE-----HHQFTIIG--DTLTAYTSFPS 142
Cdd:cd03396    47 VLLLALALLFFRRKRLRRRRRALLLLILVIGLGllvvAILKSHWGRPRPWDLTEfggdaPYTPLFSGpsNGCGKGCSFPS 126

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1394421523 143 GHTITIFTAISAMVFVLLREAKisekHKTYWIYLSLMVATVVAISRVAVGAHW 195
Cdd:cd03396   127 GHASAGFALLALYFLFRRRRPR----LARLVLAAGLALGALMGLARMARGAHF 175
PRK11837 PRK11837
undecaprenyl pyrophosphate phosphatase; Provisional
 138-212 2.11e-04

undecaprenyl pyrophosphate phosphatase; Provisional


Pssm-ID: 183335  Cd Length: 202  Bit Score: 41.54  E-value: 2.11e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1394421523 138 TSFPSGHTITIFTAISAMVFVllreakisekHKTyWIYLSLM-VATVVAISRVAVGAHWPADLASGAIIGTVSGLS 212
Cdd:PRK11837  103 DSFPSDHGTVIFTFALAFLFW----------HRL-WSGSLLMaIAVAIAWSRVYLGVHWPLDMLGALLVGMIGCLS 167
PAP2_acid_phosphatase cd03397
PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes ...
 110-208 8.03e-04

PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains to be determined.


Pssm-ID: 239491  Cd Length: 232  Bit Score: 40.01  E-value: 8.03e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394421523 110 KSFFAIPRPAAVlehHQFTIIGDTLTAYT----SFPSGHTitiftAISAMVFVLLREAkISEKhktywiYLSLMV-ATVV 184
Cdd:cd03397   121 KKYYNRPRPFVL---NDEPICTPPDESGLakdgSYPSGHT-----AAGYAWALILAEL-VPER------ADEILArGSEY 185

                          90       100
                  ....*....|....*....|....
gi 1394421523 185 AISRVAVGAHWPADLASGAIIGTV 208
Cdd:cd03397   186 GQSRIVCGVHWPSDVMGGRIMAAA 209
PAP2_like_3 cd03393
PAP2_like_3 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
 76-208 8.06e-04

PAP2_like_3 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria and archaea, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


Pssm-ID: 239487 [Multi-domain]  Cd Length: 125  Bit Score: 38.51  E-value: 8.06e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394421523  76 ILIPLlsFICLVNTRMWAAMFGAVPLACALSHLGKSFFAIPRPAAVLehhQFTIIGDTLTAYTSFPSGH---TITIFTAI 152
Cdd:cd03393     1 IVLSL--IYWLVDKRLGRYLGLALCASGYLNAALKEVFKIPRPFTYD---GIQAIYEESAGGYGFPSGHaqtSATFWGSL 75

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1394421523 153 SAMVfvllreakiseKHKTYWiYLSLMVATVVAISRVAVGAHWPADLASGAIIGTV 208
Cdd:cd03393    76 MLHV-----------RKKWFT-LIGVVLVVLISFSRLYLGVHWPSDVIGGVLIGLL 119
COG3907 COG3907
Membrane-associated enzyme, PAP2 (acid phosphatase) superfamily [General function prediction ...
 64-209 1.18e-03

Membrane-associated enzyme, PAP2 (acid phosphatase) superfamily [General function prediction only];


Pssm-ID: 443113  Cd Length: 236  Bit Score: 39.49  E-value: 1.18e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394421523  64 IWHNITYLG--DALILIPLLSFICLV------NTRMWAAMFGAVPLACALS----HLGKSFFAIPRPAAVLE-------H 124
Cdd:COG3907    58 LLELLLHDGgkWLVILVAVLLLLLLLasfkrpRLRRYRRRLLYLLLSLALGllvvSLLKSHTGRPCPWDLVEfggdapyV 137

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394421523 125 HQFTIIGDTLTAYTSFPSGHTITIFtAISAMVFVLLREAKiseKHKTYWIYLSLMVATVVAISRVAVGAHWPAD-LASGA 203
Cdd:COG3907   138 PLFEPGPAGAGPGRCFPAGHASAGF-ALLALYFLLRRRRP---RLARLGLAAGLALGLLMGLAQMLRGAHFLSHtLWSAW 213


                  ....*.
gi 1394421523 204 IIGTVS 209
Cdd:COG3907   214 ICWLVA 219
PRK10699 PRK10699
phosphatidylglycerophosphatase B; Provisional
 139-205 1.39e-03

phosphatidylglycerophosphatase B; Provisional


Pssm-ID: 182658  Cd Length: 244  Bit Score: 39.24  E-value: 1.39e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1394421523 139 SFPSGHTItiFTAISAMVFVLLreakISEKHKTYWIYLSLMVATVVAISRVAVGAHWPADLASGAII 205
Cdd:PRK10699  158 AFPSGHTM--FAASWALLAVGL----LWPRRRYKTVALLMLWATGVMGSRLLLGMHWPRDLVVATLI 218
PLN02250 PLN02250
lipid phosphate phosphatase
 137-206 3.23e-03

lipid phosphate phosphatase


Pssm-ID: 215139  Cd Length: 314  Bit Score: 38.37  E-value: 3.23e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1394421523 137 YTSFPSGHTITIFTAISAMVFVLLREAKISEKH----KTYWIYLSLMVATVVAISRVAVGAHWPADLASGAIIG 206
Cdd:PLN02250  160 HKSFPSGHTSWSFAGLGFLSLYLSGKIRVFDRRghvaKLCIVFLPLLVAALVGVSRVDDYWHHWQDVFAGALIG 233
PAP2_wunen cd03384
PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid ...
 136-211 3.43e-03

PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the survival of PGCs and is essential in the migration process of these cells towards the somatic gonadal precursors.


Pssm-ID: 239479  Cd Length: 150  Bit Score: 37.22  E-value: 3.43e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394421523 136 AYTSFPSGHTITiftAISAMVFVLL-----REAKISEKHKTYWIYLSLMVATVVAISRVAVGAHWPADLASGAIIGTVSG 210
Cdd:cd03384    70 ARLSFPSGHASL---SMYAAVFLALylqarLKLRGSRLLRPLLQFLLLALALYVGLSRISDYKHHWSDVLAGALLGSVIA 146


                  .
gi 1394421523 211 L 211
Cdd:cd03384   147 L 147
PAP2_haloperoxidase cd03398
PAP2, haloperoxidase_like subfamily. Haloperoxidases catalyze the oxidation of halides such as ...
 125-206 7.71e-03

PAP2, haloperoxidase_like subfamily. Haloperoxidases catalyze the oxidation of halides such as bromide or chloride by hydrogen peroxide, which results in subsequent halogenation of organic substrates, or halide-assisted disproportionation of hydrogen peroxide forming dioxygen. They are likely to participate in the biosynthesis of halogenated natural products, such as volatile halogenated hydrocarbons, chiral halogenated terpenes, acetogenins and indoles.


Pssm-ID: 239492  Cd Length: 232  Bit Score: 37.02  E-value: 7.71e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394421523 125 HQFTIIGDTLTAYT------SFPSGHTITiftaiSAMVFVLLRE--------AKISEKHK--------TYWIYLSLMvAT 182
Cdd:cd03398   126 NPATEADPYWLPLAgtpphpSYPSGHATF-----AGAAATVLKAlfgsdkvpDTVSEPDEggpstgvtRVWAELNEL-AD 199

                          90       100
                  ....*....|....*....|....
gi 1394421523 183 VVAISRVAVGAHWPADLASGAIIG 206
Cdd:cd03398   200 EVAISRVYAGVHFRSDDAAGAALG 223
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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