View
Concise Results
Standard Results
Full Results
MULTISPECIES: pyruvate dehydrogenase (acetyl-transferring), homodimeric type [Aurantimicrobium]
Protein Classification
AceE family protein ( domain architecture ID 11457666 )
AceE family protein
List of domain hits
Name
Accession
Description
Interval
E-value
AceE
COG2609 Pyruvate dehydrogenase complex, dehydrogenase (E1) component [Energy production and conversion] ...
6-903
0e+00
Pyruvate dehydrogenase complex, dehydrogenase (E1) component [Energy production and conversion]; Pyruvate dehydrogenase complex, dehydrogenase (E1) component is part of the Pathway/BioSystem: Pyruvate oxidation
Pssm-ID: 442021 [Multi-domain]
Cd Length: 891
Bit Score: 1773.84
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398205110 6 Q D PYSVSNY D A DPQET A EW N ESLD G V VASQ G H ER G R DIMLS LL R R SKELHL G V P MVP TT D Y L NTI AP E N EP AF PGDEE T E 85
Cdd:COG2609 3 M D GLPSQLP D I DPQET Q EW L ESLD A V IEEE G P ER A R YLLER LL E R ARRSGV G L P FSA TT P Y I NTI PV E Q EP PY PGDEE L E 82
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398205110 86 RR Y R AW IRWNA AML V H RA Q R P G I G V GGHISS Y AS SSS LYEVGFNHFFRG Q DHPGGGD QIFV QGHASPG V YARAFLEGRL N 165
Cdd:COG2609 83 RR I R SI IRWNA MAM V V RA N R K G G G L GGHISS F AS AAT LYEVGFNHFFRG P DHPGGGD LVYF QGHASPG I YARAFLEGRL T 162
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398205110 166 E S QLD G FRQE K sh A G G GLSSYPHP R LMPDFWQFPTVSMGLGPINAIYQA QLNR YL T NRG I KD A SD QQ VWAFLGDGEMDE V 245
Cdd:COG2609 163 E E QLD N FRQE V -- D G K GLSSYPHP W LMPDFWQFPTVSMGLGPINAIYQA RFMK YL H NRG L KD T SD RK VWAFLGDGEMDE P 240
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398205110 246 ES R G QLQV AA N E G LDNL N FVINCNLQRLDGPVRGNGKIIQELE SF FRGAGWNVIKVIWG R EWD S LLA N D H DGAL RTL MN V 325
Cdd:COG2609 241 ES L G AISL AA R E K LDNL I FVINCNLQRLDGPVRGNGKIIQELE GV FRGAGWNVIKVIWG S EWD P LLA K D T DGAL VKR MN E 320
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398205110 326 T P DGD F QTYK TE DGA F VRE N FF ARD P RALK LV EH MSD D D V W K L K RGGHD YN KVYAA F KAA S EHKGQPTVILA H TIKGYG L 405
Cdd:COG2609 321 T V DGD Y QTYK AK DGA Y VRE H FF GKY P ELKA LV AD MSD E D I W R L N RGGHD PR KVYAA Y KAA V EHKGQPTVILA K TIKGYG M 400
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398205110 406 G KHF EGRN A THQ M KK MK LDDLK LM RD FLK IPI T D AV LEE npym P PYYKP EDND P RLQ Y M HERR RE LGGY V P E RR S K YTEI 485
Cdd:COG2609 401 G EAG EGRN I THQ Q KK LD LDDLK AF RD RFN IPI S D EQ LEE ---- L PYYKP AEDS P EMK Y L HERR KA LGGY L P Q RR T K AEPL 476
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398205110 486 AL PE KKTYDIAA KGSG VQ E VA TTM G FVR L L K DL IR DKE F G P R L VPI I PDEARTFGM DTF F PNAK IY N P N GQ H Y MS VD R D L 565
Cdd:COG2609 477 EV PE LSAFAALL KGSG KR E IS TTM A FVR I L N DL LK DKE I G K R I VPI V PDEARTFGM EGL F RQIG IY S P V GQ L Y TP VD A D Q 556
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398205110 566 LL A YKE DPT G T I IHV GINEAGA LAAFT A V G S SYST Q G EIL IP I Y VF YSMFGFQR T GD AL W L AGDQ MV RGF V IGATAGRTT 645
Cdd:COG2609 557 LL Y YKE SKD G Q I LQE GINEAGA MSSWI A A G T SYST H G VPM IP F Y IY YSMFGFQR V GD LA W A AGDQ RA RGF L IGATAGRTT 636
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398205110 646 L T GEGLQH A DGHS PI LA A T N P AV V T YDPA YT YE IGH I MR DGL Q RMYG gth PDP NV M YYITV Y NE PIQ QPA E PE NLD v D G V 725
Cdd:COG2609 637 L N GEGLQH Q DGHS HL LA S T I P NC V S YDPA FA YE LAV I VQ DGL R RMYG --- EQE NV F YYITV M NE NYA QPA M PE GVE - E G I 712
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398205110 726 L R G I Y K L Q E NDMP - GVKS Q I L A SG VAVPWA L E A QK LLAEDWGV S ADVWSVTS WG ELRRDG IAADHF N MMN PE APAQ VPYV 804
Cdd:COG2609 713 L K G M Y L L K E GEGK g KPRV Q L L G SG TILREV L A A AE LLAEDWGV A ADVWSVTS FN ELRRDG LDVERW N LLH PE EEPR VPYV 792
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398205110 805 T EK L S GAEGP F VA V TDY NHM VPD L IRP YI PG D Y AT LG A DGFG F SDTR A A A RRFF TI D GP S V VV RT L EQ LA KQ GK V D RGL V 884
Cdd:COG2609 793 T QC L A GAEGP V VA A TDY MRA VPD Q IRP WV PG R Y TV LG T DGFG R SDTR E A L RRFF EV D RY S I VV AA L KA LA DE GK I D ASV V 872
890
....*....|....*....
gi 1398205110 885 RQ AI E KY RLYDVTAGTTGS 903
Cdd:COG2609 873 AE AI K KY GIDPDKPNPLTA 891
Name
Accession
Description
Interval
E-value
AceE
COG2609 Pyruvate dehydrogenase complex, dehydrogenase (E1) component [Energy production and conversion] ...
6-903
0e+00
Pyruvate dehydrogenase complex, dehydrogenase (E1) component [Energy production and conversion]; Pyruvate dehydrogenase complex, dehydrogenase (E1) component is part of the Pathway/BioSystem: Pyruvate oxidation
Pssm-ID: 442021 [Multi-domain]
Cd Length: 891
Bit Score: 1773.84
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398205110 6 Q D PYSVSNY D A DPQET A EW N ESLD G V VASQ G H ER G R DIMLS LL R R SKELHL G V P MVP TT D Y L NTI AP E N EP AF PGDEE T E 85
Cdd:COG2609 3 M D GLPSQLP D I DPQET Q EW L ESLD A V IEEE G P ER A R YLLER LL E R ARRSGV G L P FSA TT P Y I NTI PV E Q EP PY PGDEE L E 82
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398205110 86 RR Y R AW IRWNA AML V H RA Q R P G I G V GGHISS Y AS SSS LYEVGFNHFFRG Q DHPGGGD QIFV QGHASPG V YARAFLEGRL N 165
Cdd:COG2609 83 RR I R SI IRWNA MAM V V RA N R K G G G L GGHISS F AS AAT LYEVGFNHFFRG P DHPGGGD LVYF QGHASPG I YARAFLEGRL T 162
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398205110 166 E S QLD G FRQE K sh A G G GLSSYPHP R LMPDFWQFPTVSMGLGPINAIYQA QLNR YL T NRG I KD A SD QQ VWAFLGDGEMDE V 245
Cdd:COG2609 163 E E QLD N FRQE V -- D G K GLSSYPHP W LMPDFWQFPTVSMGLGPINAIYQA RFMK YL H NRG L KD T SD RK VWAFLGDGEMDE P 240
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398205110 246 ES R G QLQV AA N E G LDNL N FVINCNLQRLDGPVRGNGKIIQELE SF FRGAGWNVIKVIWG R EWD S LLA N D H DGAL RTL MN V 325
Cdd:COG2609 241 ES L G AISL AA R E K LDNL I FVINCNLQRLDGPVRGNGKIIQELE GV FRGAGWNVIKVIWG S EWD P LLA K D T DGAL VKR MN E 320
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398205110 326 T P DGD F QTYK TE DGA F VRE N FF ARD P RALK LV EH MSD D D V W K L K RGGHD YN KVYAA F KAA S EHKGQPTVILA H TIKGYG L 405
Cdd:COG2609 321 T V DGD Y QTYK AK DGA Y VRE H FF GKY P ELKA LV AD MSD E D I W R L N RGGHD PR KVYAA Y KAA V EHKGQPTVILA K TIKGYG M 400
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398205110 406 G KHF EGRN A THQ M KK MK LDDLK LM RD FLK IPI T D AV LEE npym P PYYKP EDND P RLQ Y M HERR RE LGGY V P E RR S K YTEI 485
Cdd:COG2609 401 G EAG EGRN I THQ Q KK LD LDDLK AF RD RFN IPI S D EQ LEE ---- L PYYKP AEDS P EMK Y L HERR KA LGGY L P Q RR T K AEPL 476
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398205110 486 AL PE KKTYDIAA KGSG VQ E VA TTM G FVR L L K DL IR DKE F G P R L VPI I PDEARTFGM DTF F PNAK IY N P N GQ H Y MS VD R D L 565
Cdd:COG2609 477 EV PE LSAFAALL KGSG KR E IS TTM A FVR I L N DL LK DKE I G K R I VPI V PDEARTFGM EGL F RQIG IY S P V GQ L Y TP VD A D Q 556
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398205110 566 LL A YKE DPT G T I IHV GINEAGA LAAFT A V G S SYST Q G EIL IP I Y VF YSMFGFQR T GD AL W L AGDQ MV RGF V IGATAGRTT 645
Cdd:COG2609 557 LL Y YKE SKD G Q I LQE GINEAGA MSSWI A A G T SYST H G VPM IP F Y IY YSMFGFQR V GD LA W A AGDQ RA RGF L IGATAGRTT 636
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398205110 646 L T GEGLQH A DGHS PI LA A T N P AV V T YDPA YT YE IGH I MR DGL Q RMYG gth PDP NV M YYITV Y NE PIQ QPA E PE NLD v D G V 725
Cdd:COG2609 637 L N GEGLQH Q DGHS HL LA S T I P NC V S YDPA FA YE LAV I VQ DGL R RMYG --- EQE NV F YYITV M NE NYA QPA M PE GVE - E G I 712
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398205110 726 L R G I Y K L Q E NDMP - GVKS Q I L A SG VAVPWA L E A QK LLAEDWGV S ADVWSVTS WG ELRRDG IAADHF N MMN PE APAQ VPYV 804
Cdd:COG2609 713 L K G M Y L L K E GEGK g KPRV Q L L G SG TILREV L A A AE LLAEDWGV A ADVWSVTS FN ELRRDG LDVERW N LLH PE EEPR VPYV 792
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398205110 805 T EK L S GAEGP F VA V TDY NHM VPD L IRP YI PG D Y AT LG A DGFG F SDTR A A A RRFF TI D GP S V VV RT L EQ LA KQ GK V D RGL V 884
Cdd:COG2609 793 T QC L A GAEGP V VA A TDY MRA VPD Q IRP WV PG R Y TV LG T DGFG R SDTR E A L RRFF EV D RY S I VV AA L KA LA DE GK I D ASV V 872
890
....*....|....*....
gi 1398205110 885 RQ AI E KY RLYDVTAGTTGS 903
Cdd:COG2609 873 AE AI K KY GIDPDKPNPLTA 891
aceE
PRK09405 pyruvate dehydrogenase subunit E1; Reviewed
15-903
0e+00
pyruvate dehydrogenase subunit E1; Reviewed
Pssm-ID: 236500 [Multi-domain]
Cd Length: 891
Bit Score: 1725.76
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398205110 15 D A DP Q ET A EW N E S LD G V VASQ G H ER GRDIMLS LL R R SK E LHLGV P MVP TT D Y L NTI AP E N EP AF PGD E E T ERR Y R AW IRW 94
Cdd:PRK09405 11 D I DP I ET Q EW L E A LD S V IREE G P ER AHYLLEQ LL E R AR E KGVSL P ASA TT P Y I NTI PV E E EP EY PGD L E L ERR I R SY IRW 90
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398205110 95 NAA ML V H RA QRPGI G V GGHISS Y ASS SS LYEVGFNHFFR GQDH P G GGD QI F V QGHASPG V YARAFLEGRL N E S QLD G FRQ 174
Cdd:PRK09405 91 NAA AM V L RA NKKDL G L GGHISS F ASS AT LYEVGFNHFFR APNE P H GGD LV F F QGHASPG I YARAFLEGRL T E E QLD N FRQ 170
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398205110 175 E KS ha G G GLSSYPHP R LMPDFWQFPTVSMGLGPI N AIYQA QLNR YL T NRG I KD A SDQ Q VWAFLGDGEMDE V ES R G QLQV A 254
Cdd:PRK09405 171 E VD -- G K GLSSYPHP W LMPDFWQFPTVSMGLGPI M AIYQA RFLK YL E NRG L KD T SDQ K VWAFLGDGEMDE P ES L G AISL A 248
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398205110 255 A N E G LDNL N FVINCNLQRLDGPVRGNGKIIQELE SF FRGAGWNVIKVIWG RE WD S LLA N D HD G A L RT LMN V T P DGD F QTY 334
Cdd:PRK09405 249 A R E K LDNL I FVINCNLQRLDGPVRGNGKIIQELE GI FRGAGWNVIKVIWG SR WD P LLA K D TS G K L VQ LMN E T V DGD Y QTY 328
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398205110 335 K TE DGA F VRE N FF ARD P RALK LV EH MSDDD V W K L K RGGHD YN KVYAA F KAA S EHKGQPTVILA H TIKGYG L G KHF EG R N A 414
Cdd:PRK09405 329 K AK DGA Y VRE H FF GKY P ETKA LV AD MSDDD I W A L N RGGHD PR KVYAA Y KAA V EHKGQPTVILA K TIKGYG M G EAG EG K N I 408
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398205110 415 T HQ M KK MK LDDLK LM RD FLK IPI T D AV LE EN pymp PYYKP EDND P RLQ Y M HERR RE LGGY V P E RR S K YTEIAL P EKKTYD 494
Cdd:PRK09405 409 A HQ V KK LD LDDLK HF RD RFN IPI S D EQ LE KL ---- PYYKP GEDS P EIK Y L HERR KA LGGY L P A RR P K FEPLEV P ALSAFE 484
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398205110 495 IAA KGSG VQ E VA TTM G FVR L L KD L IR DKE F G P R L VPIIPDEARTFGM DTF F PNAK IYNP N GQ H Y MS VDRD L L LA YKE DPT 574
Cdd:PRK09405 485 ALL KGSG ER E IS TTM A FVR I L NI L LK DKE I G K R I VPIIPDEARTFGM EGL F RQIG IYNP H GQ L Y TP VDRD Q L MY YKE SKD 564
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398205110 575 G T I IHV GINEAGA L A AFT A VGS SYST Q GE IL IP I Y VF YSMFGFQR T GD AL W L AGDQ MV RGF VI G A TAGRTTL T GEGLQH A 654
Cdd:PRK09405 565 G Q I LQE GINEAGA M A SWI A AAT SYST H GE PM IP F Y IY YSMFGFQR I GD LA W A AGDQ RA RGF LL G G TAGRTTL N GEGLQH E 644
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398205110 655 DGHS P ILA A T N P AV V T YDPA YT YE IGH I MR DGL Q RMYG gth PDP NV M YYITV Y NE PIQ QPA E PE NLD v D G V L R G I YKL Q - 733
Cdd:PRK09405 645 DGHS H ILA S T I P NC V S YDPA FA YE VAV I VQ DGL R RMYG --- EQE NV F YYITV M NE NYH QPA M PE GAE - E G I L K G M YKL E t 720
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398205110 734 - E NDMPGV K S Q I L A SG VAVPWA LEA QKL LAED W GV S ADVWSVTS WG EL R RDG IAADHF NM MN P EAPAQ VPYVT EK L S GAE 812
Cdd:PRK09405 721 a E GKKGKP K V Q L L G SG TILREV LEA AEI LAED Y GV A ADVWSVTS FN EL A RDG QDVERW NM LH P TEEPR VPYVT QV L K GAE 800
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398205110 813 GP F VA V TDY NHMVPDL IR PYI PGDY AT LG A DGFG F SDTR A A A RRFF TI D GPS VVV RT L EQ LA KQ G KV D RGL V RQ AI E KY R 892
Cdd:PRK09405 801 GP V VA A TDY MKLFAEQ IR AFV PGDY VV LG T DGFG R SDTR E A L RRFF EV D AEY VVV AA L KA LA DE G EI D ASV V AE AI K KY G 880
890
....*....|.
gi 1398205110 893 LYDVT A GTTGS 903
Cdd:PRK09405 881 IDPDK A NPRTA 891
aceE
TIGR00759 pyruvate dehydrogenase E1 component, homodimeric type; Most members of this family are ...
15-899
0e+00
pyruvate dehydrogenase E1 component, homodimeric type; Most members of this family are pyruvate dehydrogenase complex, E1 component. Note: this family was classified as subfamily rather than equivalog because it includes a counterexample from Pseudomonas putida, MdeB, that is active as an E1 component of an alpha-ketoglutarate dehydrogenase complex rather than a pyruvate dehydrogase complex. The second pyruvate dehydrogenase complex E1 protein from Alcaligenes eutrophus, PdhE, complements an aceE mutant of E. coli but is not part of a pyruvate dehydrogenase complex operon, is more similar to the Pseudomonas putida MdeB than to E. coli AceE, and may have also have a different primary specificity.
Pssm-ID: 273255 [Multi-domain]
Cd Length: 885
Bit Score: 1315.91
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398205110 15 D A DP Q ET A EW N ESLD G V V A SQ G HE R G R DIMLS LL RRSK E LHLGV P MVP TTDY L NTI AP E NE PA F PGD E E T ERR Y R AW IRW 94
Cdd:TIGR00759 5 D V DP I ET Q EW L ESLD S V L A EE G PA R A R YLLEQ LL EYAR E HGVPI P AGT TTDY I NTI PV E EQ PA Y PGD L E L ERR I R SI IRW 84
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398205110 95 NA AML V H RA QRPGI G V GGHIS S YAS SSS LYEVGFNHFFRG QDHP GGGD QI F V QGHA S PG V YARAFLEGRL N E S QLD G FRQ 174
Cdd:TIGR00759 85 NA IAM V L RA NKKDL G L GGHIS T YAS AAT LYEVGFNHFFRG HSEG GGGD LV F F QGHA A PG I YARAFLEGRL T E E QLD N FRQ 164
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398205110 175 E ks HA G G GLSSYPHP R LMPDFWQFPTVSMGLGPINAIYQA QLNR YL T NRG I KD AS DQ Q VWAFLGDGEMDE V ES R G QLQV A 254
Cdd:TIGR00759 165 E -- VQ G D GLSSYPHP W LMPDFWQFPTVSMGLGPINAIYQA RFMK YL E NRG L KD TG DQ K VWAFLGDGEMDE P ES K G AITF A 242
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398205110 255 A N E G LDNL N FVINCNLQRLDGPVRGNGKIIQELES F FRGAGWNVIKV I WG R EWD S LLA N D HD G A L RT LMN V T P DGD F QTY 334
Cdd:TIGR00759 243 A R E K LDNL T FVINCNLQRLDGPVRGNGKIIQELES L FRGAGWNVIKV L WG S EWD A LLA R D TS G V L VK LMN E T V DGD Y QTY 322
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398205110 335 K TE DGA F VRE N FF A R D P RALK LV EH MSD D D V W K L K RGGHD YN KVYAA FK AA S EHKGQPTVILA H TIKGYG L G KHF E G RN A 414
Cdd:TIGR00759 323 K AK DGA Y VRE H FF N R T P ELKA LV AD MSD A D I W A L N RGGHD PR KVYAA YA AA Q EHKGQPTVILA K TIKGYG M G DAA E S RN T 402
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398205110 415 T HQ M KK MKL D D LK LM RD FLKI P IT DA VL EE npym P PYY K P EDND P RLQ Y MHE RR RE LGGY V P E RR SKYTEIAL P EKKTYD 494
Cdd:TIGR00759 403 A HQ V KK LEV D A LK NF RD RFEL P LS DA QV EE ---- L PYY H P GEGS P EVR Y LLA RR QA LGGY L P A RR TFAEHLTV P ALEFFG 478
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398205110 495 IAA KGSG VQ EV A TTM G FVR L L KD L IR DKE F G P R L VPI I PDEARTFGM DTF F PNAK IY N P N GQ H Y MS VD R D L LLAYKE DPT 574
Cdd:TIGR00759 479 ALL KGSG ER EV S TTM A FVR I L NK L LK DKE I G K R I VPI V PDEARTFGM EGL F RQIG IY S P H GQ T Y TP VD A D S LLAYKE SKD 558
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398205110 575 G T I IHV GINEAGA L A AFT A VGS SY S T Q GE IL IP I Y VF YSMFGFQR T GD AL W L A G DQ MV RGF VI GATAGRTTL T GEGLQH A 654
Cdd:TIGR00759 559 G Q I LQE GINEAGA M A SWI A AAT SY A T H GE PM IP F Y IY YSMFGFQR I GD LC W A A A DQ RA RGF LL GATAGRTTL N GEGLQH E 638
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398205110 655 DGHS PIL AAT N P AVVT YDPA YT YE IGH IM R DGL Q RMYG gth PDPN V M YY I TV Y NE PIQ QP AE PE N l DVD G V L R G I Y KLQE 734
Cdd:TIGR00759 639 DGHS LLQ AAT I P NCIA YDPA FA YE VAV IM E DGL R RMYG --- EQED V F YY V TV M NE NYV QP PM PE G - AEE G I L K G L Y RFET 714
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398205110 735 NDMPGV K S -- Q I L A SG VAVPWAL EA QK LLA E DWGV SA DVWSVTS WG EL R RDG IAADHF N MMN P EAPAQ V P YV TEK L SG A E 812
Cdd:TIGR00759 715 STEEKA K G hv Q L L G SG AIMRAVI EA AQ LLA A DWGV AS DVWSVTS FT EL A RDG HDVERW N LLH P TETPR V S YV AQV L NE A D 794
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398205110 813 G P FV A V TDY NHMVPDL IRPY I P GD Y A TLG A DGFG F SDTR AAA R R FF TI D GP SVV VRT L EQ LA KQ G KV D RGL V RQ AI E KY R 892
Cdd:TIGR00759 795 A P VI A S TDY VRAFAEQ IRPY V P RK Y V TLG T DGFG R SDTR ENL R H FF EV D AK SVV LAA L YA LA DD G EI D GDV V AD AI A KY G 874
....*..
gi 1398205110 893 LYDVT A G 899
Cdd:TIGR00759 875 IDPDK A N 881
TPP_E1_EcPDC_like
cd02017 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; ...
82-473
0e+00
Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative decarboxylation of pyruvate and the subsequent acetylation of coenzyme A to acetyl-CoA. The E1 component of PDC catalyzes the first step of the multistep process, using TPP and a divalent cation as cofactors. E. coli PDC is a homodimeric enzyme.
Pssm-ID: 238975 [Multi-domain]
Cd Length: 386
Bit Score: 670.17
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398205110 82 E E T ERR Y R AW IRWNA AML VHRA QRPGI G V GGHI SSY AS SSS LYEVGFNHFFR GQDHP GGGD QIFV QGHASPG V YARAFLE 161
Cdd:cd02017 1 L E I ERR I R SL IRWNA MAM VHRA NKKDL G I GGHI ATF AS AAT LYEVGFNHFFR ARGEG GGGD LVYF QGHASPG I YARAFLE 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398205110 162 GRL N E S QLD G FRQE ks HA GGGLSSYPHP R LMPDFW Q FPTVSMGLGPI N AIYQA QL NRYL TN RG I KD A SDQ Q VWAFLGDGE 241
Cdd:cd02017 81 GRL T E E QLD N FRQE -- VG GGGLSSYPHP W LMPDFW E FPTVSMGLGPI Q AIYQA RF NRYL ED RG L KD T SDQ K VWAFLGDGE 158
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398205110 242 MDE V ES R G QLQV AA N E G LDNL N FV I NCNLQRLDGPVRGNGKIIQELE SF FRGAGWNVIKVIWG RE WD S LLA N D HD GALR T 321
Cdd:cd02017 159 MDE P ES L G AIGL AA R E K LDNL I FV V NCNLQRLDGPVRGNGKIIQELE GI FRGAGWNVIKVIWG SK WD E LLA K D GG GALR Q 238
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398205110 322 L M NV T P DGD F QT Y K TE DGA F VRE N FF ARD P RALK LV EHM SD D D V W K L K RGGHD YN KVYAA F K A A S EHKG Q PTVILA H TIK 401
Cdd:cd02017 239 R M EE T V DGD Y QT L K AK DGA Y VRE H FF GKY P ELKA LV TDL SD E D L W A L N RGGHD PR KVYAA Y K K A V EHKG K PTVILA K TIK 318
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1398205110 402 GYGLG KHF EGRN AT HQ M KKM KL D D LK LM RD FLK IP IT D AV LEE N pymp PYYKP EDNDPRLQ Y M HERR RE LGG 473
Cdd:cd02017 319 GYGLG AAG EGRN HA HQ V KKM TE D E LK AL RD RFG IP VS D EQ LEE G ---- PYYKP PEGSEEIK Y L HERR HA LGG 386
PDH_E1_M
pfam17831 Pyruvate dehydrogenase E1 component middle domain; This entry represents one of the thiamin ...
484-714
4.76e-76
Pyruvate dehydrogenase E1 component middle domain; This entry represents one of the thiamin diphosphate-binding domains found in pyruvate dehydrogenase E1 component.
Pssm-ID: 465525 [Multi-domain]
Cd Length: 229
Bit Score: 247.72
E-value: 4.76e-76
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398205110 484 EI ALPEK K TYDIAAK GS GVQ E VA TTM G FVR L L KD L IR DK EF G PRL VPIIPDEARTFGM DTF F PNAK IY NPN GQ H Y MS VD R 563
Cdd:pfam17831 2 EI PDLDD K IFASQTG GS KGR E IS TTM A FVR I L NG L VK DK KI G KQV VPIIPDEARTFGM EGM F RQLG IY TSE GQ K Y EP VD K 81
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398205110 564 DLLLA Y K ED PT G T I IHV GI N EAGA LA A FT A VGS SYS TQGEI L I P I YV F YSMFGFQR T GD AL W L AGD QMV RGF VI G A TAGR 643
Cdd:pfam17831 82 GQIMF Y R ED KQ G Q I LEE GI S EAGA MS A WI A AAT SYS NHNTT L L P F YV Y YSMFGFQR I GD LA W A AGD MQA RGF LV G G TAGR 161
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1398205110 644 TTL T GEGLQH A DGHS P I L A A T N P AVVT YDP A Y TY E IGH I MR DGL Q RM YGGTH pdp N VM YY I TV Y NE PIQQ P 714
Cdd:pfam17831 162 TTL N GEGLQH Q DGHS H I Q A S T I P NCRS YDP T Y AH E VAV I VQ DGL K RM FADKE --- N CF YY L TV M NE NYEH P 229
Transket_pyr
smart00861 Transketolase, pyrimidine binding domain; Transketolase (TK) catalyzes the reversible transfer ...
578-703
7.08e-05
Transketolase, pyrimidine binding domain; Transketolase (TK) catalyzes the reversible transfer of a two-carbon ketol unit from xylulose 5-phosphate to an aldose receptor, such as ribose 5-phosphate, to form sedoheptulose 7-phosphate and glyceraldehyde 3- phosphate. This enzyme, together with transaldolase, provides a link between the glycolytic and pentose-phosphate pathways. TK requires thiamine pyrophosphate as a cofactor. In most sources where TK has been purified, it is a homodimer of approximately 70 Kd subunits. TK sequences from a variety of eukaryotic and prokaryotic sources show that the enzyme has been evolutionarily conserved. In the peroxisomes of methylotrophic yeast Hansenula polymorpha, there is a highly related enzyme, dihydroxy-acetone synthase (DHAS) (also known as formaldehyde transketolase), which exhibits a very unusual specificity by including formaldehyde amongst its substrates.
Pssm-ID: 214865 [Multi-domain]
Cd Length: 136
Bit Score: 43.63
E-value: 7.08e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398205110 578 I HV GI N E AGALAA ft A V G ss YSTQ G ei L I P IYVFYSM F g F Q R TG D ALWL AG DQMVRGF V I gatagrt TLT G E G LQHA DG - 656
Cdd:smart00861 18 I DT GI A E QAMVGF -- A A G -- LALH G -- L R P VVEIFFT F - F D R AK D QIRS AG ASGNVPV V F ------- RHD G G G GVGE DG p 83
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 1398205110 657 - H SP I ----- L A A T n P AVVTYD P AYTY E IGHIM R DGLQ rmyggt HPD P N V MYY 703
Cdd:smart00861 84 t H HS I edeal L R A I - P GLKVVA P SDPA E AKGLL R AAIR ------ DDG P V V IRL 129
Name
Accession
Description
Interval
E-value
AceE
COG2609 Pyruvate dehydrogenase complex, dehydrogenase (E1) component [Energy production and conversion] ...
6-903
0e+00
Pyruvate dehydrogenase complex, dehydrogenase (E1) component [Energy production and conversion]; Pyruvate dehydrogenase complex, dehydrogenase (E1) component is part of the Pathway/BioSystem: Pyruvate oxidation
Pssm-ID: 442021 [Multi-domain]
Cd Length: 891
Bit Score: 1773.84
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398205110 6 Q D PYSVSNY D A DPQET A EW N ESLD G V VASQ G H ER G R DIMLS LL R R SKELHL G V P MVP TT D Y L NTI AP E N EP AF PGDEE T E 85
Cdd:COG2609 3 M D GLPSQLP D I DPQET Q EW L ESLD A V IEEE G P ER A R YLLER LL E R ARRSGV G L P FSA TT P Y I NTI PV E Q EP PY PGDEE L E 82
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398205110 86 RR Y R AW IRWNA AML V H RA Q R P G I G V GGHISS Y AS SSS LYEVGFNHFFRG Q DHPGGGD QIFV QGHASPG V YARAFLEGRL N 165
Cdd:COG2609 83 RR I R SI IRWNA MAM V V RA N R K G G G L GGHISS F AS AAT LYEVGFNHFFRG P DHPGGGD LVYF QGHASPG I YARAFLEGRL T 162
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398205110 166 E S QLD G FRQE K sh A G G GLSSYPHP R LMPDFWQFPTVSMGLGPINAIYQA QLNR YL T NRG I KD A SD QQ VWAFLGDGEMDE V 245
Cdd:COG2609 163 E E QLD N FRQE V -- D G K GLSSYPHP W LMPDFWQFPTVSMGLGPINAIYQA RFMK YL H NRG L KD T SD RK VWAFLGDGEMDE P 240
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398205110 246 ES R G QLQV AA N E G LDNL N FVINCNLQRLDGPVRGNGKIIQELE SF FRGAGWNVIKVIWG R EWD S LLA N D H DGAL RTL MN V 325
Cdd:COG2609 241 ES L G AISL AA R E K LDNL I FVINCNLQRLDGPVRGNGKIIQELE GV FRGAGWNVIKVIWG S EWD P LLA K D T DGAL VKR MN E 320
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398205110 326 T P DGD F QTYK TE DGA F VRE N FF ARD P RALK LV EH MSD D D V W K L K RGGHD YN KVYAA F KAA S EHKGQPTVILA H TIKGYG L 405
Cdd:COG2609 321 T V DGD Y QTYK AK DGA Y VRE H FF GKY P ELKA LV AD MSD E D I W R L N RGGHD PR KVYAA Y KAA V EHKGQPTVILA K TIKGYG M 400
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398205110 406 G KHF EGRN A THQ M KK MK LDDLK LM RD FLK IPI T D AV LEE npym P PYYKP EDND P RLQ Y M HERR RE LGGY V P E RR S K YTEI 485
Cdd:COG2609 401 G EAG EGRN I THQ Q KK LD LDDLK AF RD RFN IPI S D EQ LEE ---- L PYYKP AEDS P EMK Y L HERR KA LGGY L P Q RR T K AEPL 476
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398205110 486 AL PE KKTYDIAA KGSG VQ E VA TTM G FVR L L K DL IR DKE F G P R L VPI I PDEARTFGM DTF F PNAK IY N P N GQ H Y MS VD R D L 565
Cdd:COG2609 477 EV PE LSAFAALL KGSG KR E IS TTM A FVR I L N DL LK DKE I G K R I VPI V PDEARTFGM EGL F RQIG IY S P V GQ L Y TP VD A D Q 556
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398205110 566 LL A YKE DPT G T I IHV GINEAGA LAAFT A V G S SYST Q G EIL IP I Y VF YSMFGFQR T GD AL W L AGDQ MV RGF V IGATAGRTT 645
Cdd:COG2609 557 LL Y YKE SKD G Q I LQE GINEAGA MSSWI A A G T SYST H G VPM IP F Y IY YSMFGFQR V GD LA W A AGDQ RA RGF L IGATAGRTT 636
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398205110 646 L T GEGLQH A DGHS PI LA A T N P AV V T YDPA YT YE IGH I MR DGL Q RMYG gth PDP NV M YYITV Y NE PIQ QPA E PE NLD v D G V 725
Cdd:COG2609 637 L N GEGLQH Q DGHS HL LA S T I P NC V S YDPA FA YE LAV I VQ DGL R RMYG --- EQE NV F YYITV M NE NYA QPA M PE GVE - E G I 712
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398205110 726 L R G I Y K L Q E NDMP - GVKS Q I L A SG VAVPWA L E A QK LLAEDWGV S ADVWSVTS WG ELRRDG IAADHF N MMN PE APAQ VPYV 804
Cdd:COG2609 713 L K G M Y L L K E GEGK g KPRV Q L L G SG TILREV L A A AE LLAEDWGV A ADVWSVTS FN ELRRDG LDVERW N LLH PE EEPR VPYV 792
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398205110 805 T EK L S GAEGP F VA V TDY NHM VPD L IRP YI PG D Y AT LG A DGFG F SDTR A A A RRFF TI D GP S V VV RT L EQ LA KQ GK V D RGL V 884
Cdd:COG2609 793 T QC L A GAEGP V VA A TDY MRA VPD Q IRP WV PG R Y TV LG T DGFG R SDTR E A L RRFF EV D RY S I VV AA L KA LA DE GK I D ASV V 872
890
....*....|....*....
gi 1398205110 885 RQ AI E KY RLYDVTAGTTGS 903
Cdd:COG2609 873 AE AI K KY GIDPDKPNPLTA 891
aceE
PRK09405 pyruvate dehydrogenase subunit E1; Reviewed
15-903
0e+00
pyruvate dehydrogenase subunit E1; Reviewed
Pssm-ID: 236500 [Multi-domain]
Cd Length: 891
Bit Score: 1725.76
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398205110 15 D A DP Q ET A EW N E S LD G V VASQ G H ER GRDIMLS LL R R SK E LHLGV P MVP TT D Y L NTI AP E N EP AF PGD E E T ERR Y R AW IRW 94
Cdd:PRK09405 11 D I DP I ET Q EW L E A LD S V IREE G P ER AHYLLEQ LL E R AR E KGVSL P ASA TT P Y I NTI PV E E EP EY PGD L E L ERR I R SY IRW 90
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398205110 95 NAA ML V H RA QRPGI G V GGHISS Y ASS SS LYEVGFNHFFR GQDH P G GGD QI F V QGHASPG V YARAFLEGRL N E S QLD G FRQ 174
Cdd:PRK09405 91 NAA AM V L RA NKKDL G L GGHISS F ASS AT LYEVGFNHFFR APNE P H GGD LV F F QGHASPG I YARAFLEGRL T E E QLD N FRQ 170
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398205110 175 E KS ha G G GLSSYPHP R LMPDFWQFPTVSMGLGPI N AIYQA QLNR YL T NRG I KD A SDQ Q VWAFLGDGEMDE V ES R G QLQV A 254
Cdd:PRK09405 171 E VD -- G K GLSSYPHP W LMPDFWQFPTVSMGLGPI M AIYQA RFLK YL E NRG L KD T SDQ K VWAFLGDGEMDE P ES L G AISL A 248
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398205110 255 A N E G LDNL N FVINCNLQRLDGPVRGNGKIIQELE SF FRGAGWNVIKVIWG RE WD S LLA N D HD G A L RT LMN V T P DGD F QTY 334
Cdd:PRK09405 249 A R E K LDNL I FVINCNLQRLDGPVRGNGKIIQELE GI FRGAGWNVIKVIWG SR WD P LLA K D TS G K L VQ LMN E T V DGD Y QTY 328
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398205110 335 K TE DGA F VRE N FF ARD P RALK LV EH MSDDD V W K L K RGGHD YN KVYAA F KAA S EHKGQPTVILA H TIKGYG L G KHF EG R N A 414
Cdd:PRK09405 329 K AK DGA Y VRE H FF GKY P ETKA LV AD MSDDD I W A L N RGGHD PR KVYAA Y KAA V EHKGQPTVILA K TIKGYG M G EAG EG K N I 408
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398205110 415 T HQ M KK MK LDDLK LM RD FLK IPI T D AV LE EN pymp PYYKP EDND P RLQ Y M HERR RE LGGY V P E RR S K YTEIAL P EKKTYD 494
Cdd:PRK09405 409 A HQ V KK LD LDDLK HF RD RFN IPI S D EQ LE KL ---- PYYKP GEDS P EIK Y L HERR KA LGGY L P A RR P K FEPLEV P ALSAFE 484
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398205110 495 IAA KGSG VQ E VA TTM G FVR L L KD L IR DKE F G P R L VPIIPDEARTFGM DTF F PNAK IYNP N GQ H Y MS VDRD L L LA YKE DPT 574
Cdd:PRK09405 485 ALL KGSG ER E IS TTM A FVR I L NI L LK DKE I G K R I VPIIPDEARTFGM EGL F RQIG IYNP H GQ L Y TP VDRD Q L MY YKE SKD 564
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398205110 575 G T I IHV GINEAGA L A AFT A VGS SYST Q GE IL IP I Y VF YSMFGFQR T GD AL W L AGDQ MV RGF VI G A TAGRTTL T GEGLQH A 654
Cdd:PRK09405 565 G Q I LQE GINEAGA M A SWI A AAT SYST H GE PM IP F Y IY YSMFGFQR I GD LA W A AGDQ RA RGF LL G G TAGRTTL N GEGLQH E 644
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398205110 655 DGHS P ILA A T N P AV V T YDPA YT YE IGH I MR DGL Q RMYG gth PDP NV M YYITV Y NE PIQ QPA E PE NLD v D G V L R G I YKL Q - 733
Cdd:PRK09405 645 DGHS H ILA S T I P NC V S YDPA FA YE VAV I VQ DGL R RMYG --- EQE NV F YYITV M NE NYH QPA M PE GAE - E G I L K G M YKL E t 720
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398205110 734 - E NDMPGV K S Q I L A SG VAVPWA LEA QKL LAED W GV S ADVWSVTS WG EL R RDG IAADHF NM MN P EAPAQ VPYVT EK L S GAE 812
Cdd:PRK09405 721 a E GKKGKP K V Q L L G SG TILREV LEA AEI LAED Y GV A ADVWSVTS FN EL A RDG QDVERW NM LH P TEEPR VPYVT QV L K GAE 800
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398205110 813 GP F VA V TDY NHMVPDL IR PYI PGDY AT LG A DGFG F SDTR A A A RRFF TI D GPS VVV RT L EQ LA KQ G KV D RGL V RQ AI E KY R 892
Cdd:PRK09405 801 GP V VA A TDY MKLFAEQ IR AFV PGDY VV LG T DGFG R SDTR E A L RRFF EV D AEY VVV AA L KA LA DE G EI D ASV V AE AI K KY G 880
890
....*....|.
gi 1398205110 893 LYDVT A GTTGS 903
Cdd:PRK09405 881 IDPDK A NPRTA 891
PRK13012
PRK13012 2-oxoacid dehydrogenase subunit E1; Provisional
1-896
0e+00
2-oxoacid dehydrogenase subunit E1; Provisional
Pssm-ID: 237267 [Multi-domain]
Cd Length: 896
Bit Score: 1484.42
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398205110 1 MTVND Q D P ysvsny D A DPQETAEW N E S LD G VVA SQ G H ER G R DIMLS LL R R SKELHLGV P MVP TT D Y L NTI APENE P AF PG 80
Cdd:PRK13012 11 LAAAA Q L P ------ D I DPQETAEW L E A LD A VVA HA G P ER A R YLLDR LL E R AAARGIAL P GLL TT P Y V NTI PVDQQ P PY PG 84
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398205110 81 D EET E R R YR A W IRWNA AML V H RA Q R PGIGV GGHI S SYAS SSS L Y EVGFNHFFRG Q D HP GGGD QIFV Q G H AS PG V YARAFL 160
Cdd:PRK13012 85 D LAL E E R LA A I IRWNA LAM V V RA N R AYGEL GGHI A SYAS AAD L F EVGFNHFFRG R D DA GGGD LVYF Q P H SA PG I YARAFL 164
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398205110 161 EGRL N E S QLD G FRQE KS ha G G GLSSYPHP R LMPDFWQFPT V SMG L GPINAIYQA QLN RYL TN RG I KD A S DQQ VW A F L GDG 240
Cdd:PRK13012 165 EGRL S E E QLD H FRQE IG -- G P GLSSYPHP W LMPDFWQFPT G SMG I GPINAIYQA RFM RYL QH RG L KD T S GRK VW G F F GDG 242
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398205110 241 EMDE V ES RGQ L QV AA N EGLDNL N FVINCNLQRLDGPVRGNG K IIQELE SF FRGAGWNVIKV I WG RE WD S L L A N D HD GAL R 320
Cdd:PRK13012 243 EMDE P ES IAA L SL AA R EGLDNL V FVINCNLQRLDGPVRGNG R IIQELE AL FRGAGWNVIKV L WG SD WD A L F A R D TT GAL V 322
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398205110 321 TLMNV T P DG D FQT Y K TE DGA FV RE N FF AR DP RALK LV E H M SD D D VWK LKRGGHD YN KVYAA FK AA SE HKGQPTVILA H T I 400
Cdd:PRK13012 323 RRFAE T V DG Q FQT F K AN DGA YN RE H FF GQ DP ELAA LV A H L SD E D IDR LKRGGHD PR KVYAA YA AA VR HKGQPTVILA K T K 402
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398205110 401 KGYG L G KHF EGR NA THQ M KK MKLDD LK LM RD FLKI P IT D AV LE E npym P P Y YKP EDND P RLQ Y M H E RR RE LGGY V P E RR S 480
Cdd:PRK13012 403 KGYG M G EAG EGR MT THQ Q KK LDVEA LK AF RD RFRL P LS D EQ LE Q ---- L P F YKP AEDS P EMR Y L H A RR AA LGGY L P R RR T 478
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398205110 481 KYTEIAL P EKKTYDIA A K G S G VQ E VA TTM G FVR L L KD L IR DK EF GPR L VPI IP DEARTFGM DTF F PNAK IY N P N GQ H Y MS 560
Cdd:PRK13012 479 AAPPLPV P PLSAFAQF A L G A G GK E MS TTM A FVR M L GN L LK DK AL GPR I VPI VA DEARTFGM ANL F RQVG IY S P L GQ L Y EP 558
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398205110 561 V D RDL LL A Y K E DPT G T I IHV GI N EAGA LAAFT A VGS SYS TQ G EILI P I Y VF YSMFGFQR T GD AL W L A G DQ MV RGF VI GAT 640
Cdd:PRK13012 559 E D AGS LL Y Y R E AKD G Q I LEE GI T EAGA ISSWI A AAT SYS VH G LPML P F Y IY YSMFGFQR V GD LI W A A A DQ RA RGF LL GAT 638
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398205110 641 AGRTTL T GEGLQH A DGHS PI LA A T N P AVVT YDPA YT YE IGH I MR DG LQ RM YGG thp DPN V M YY I TV Y NE PIQ QPA E PE N l 720
Cdd:PRK13012 639 AGRTTL G GEGLQH Q DGHS HL LA S T I P NCRA YDPA FA YE LAV I VD DG MR RM LEE --- QED V F YY L TV M NE NYA QPA L PE G - 714
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398205110 721 DVD G V L R G I Y K L QENDMPG v KS Q I L A SG VAVPWA L E A QK LLA E DWGV S ADVWSVTS WG ELRRDG I AA DHF N MMN P EAP A Q 800
Cdd:PRK13012 715 AEE G I L K G M Y R L AAAAEAP - RV Q L L G SG AILREV L A A AR LLA D DWGV D ADVWSVTS FT ELRRDG L AA ERA N LLG P AEE A R 793
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398205110 801 VPYVT EK L S G AE GP F VA V TDY NHM VP DL IR PYI P GD Y A TLG A DGFG F SDTRAA A RRFF TI D GP S V V VRT L EQ LA KQ G K V D 880
Cdd:PRK13012 794 VPYVT QC L A G TR GP V VA A TDY VRA VP EQ IR AFV P AR Y V TLG T DGFG R SDTRAA L RRFF EV D RH S I V LAA L KA LA DD G E V E 873
890
....*....|....*.
gi 1398205110 881 R GL V RQ AIE K Y RLY D V 896
Cdd:PRK13012 874 R TV V AE AIE R Y GID D D 889
aceE
TIGR00759 pyruvate dehydrogenase E1 component, homodimeric type; Most members of this family are ...
15-899
0e+00
pyruvate dehydrogenase E1 component, homodimeric type; Most members of this family are pyruvate dehydrogenase complex, E1 component. Note: this family was classified as subfamily rather than equivalog because it includes a counterexample from Pseudomonas putida, MdeB, that is active as an E1 component of an alpha-ketoglutarate dehydrogenase complex rather than a pyruvate dehydrogase complex. The second pyruvate dehydrogenase complex E1 protein from Alcaligenes eutrophus, PdhE, complements an aceE mutant of E. coli but is not part of a pyruvate dehydrogenase complex operon, is more similar to the Pseudomonas putida MdeB than to E. coli AceE, and may have also have a different primary specificity.
Pssm-ID: 273255 [Multi-domain]
Cd Length: 885
Bit Score: 1315.91
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398205110 15 D A DP Q ET A EW N ESLD G V V A SQ G HE R G R DIMLS LL RRSK E LHLGV P MVP TTDY L NTI AP E NE PA F PGD E E T ERR Y R AW IRW 94
Cdd:TIGR00759 5 D V DP I ET Q EW L ESLD S V L A EE G PA R A R YLLEQ LL EYAR E HGVPI P AGT TTDY I NTI PV E EQ PA Y PGD L E L ERR I R SI IRW 84
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398205110 95 NA AML V H RA QRPGI G V GGHIS S YAS SSS LYEVGFNHFFRG QDHP GGGD QI F V QGHA S PG V YARAFLEGRL N E S QLD G FRQ 174
Cdd:TIGR00759 85 NA IAM V L RA NKKDL G L GGHIS T YAS AAT LYEVGFNHFFRG HSEG GGGD LV F F QGHA A PG I YARAFLEGRL T E E QLD N FRQ 164
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398205110 175 E ks HA G G GLSSYPHP R LMPDFWQFPTVSMGLGPINAIYQA QLNR YL T NRG I KD AS DQ Q VWAFLGDGEMDE V ES R G QLQV A 254
Cdd:TIGR00759 165 E -- VQ G D GLSSYPHP W LMPDFWQFPTVSMGLGPINAIYQA RFMK YL E NRG L KD TG DQ K VWAFLGDGEMDE P ES K G AITF A 242
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398205110 255 A N E G LDNL N FVINCNLQRLDGPVRGNGKIIQELES F FRGAGWNVIKV I WG R EWD S LLA N D HD G A L RT LMN V T P DGD F QTY 334
Cdd:TIGR00759 243 A R E K LDNL T FVINCNLQRLDGPVRGNGKIIQELES L FRGAGWNVIKV L WG S EWD A LLA R D TS G V L VK LMN E T V DGD Y QTY 322
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398205110 335 K TE DGA F VRE N FF A R D P RALK LV EH MSD D D V W K L K RGGHD YN KVYAA FK AA S EHKGQPTVILA H TIKGYG L G KHF E G RN A 414
Cdd:TIGR00759 323 K AK DGA Y VRE H FF N R T P ELKA LV AD MSD A D I W A L N RGGHD PR KVYAA YA AA Q EHKGQPTVILA K TIKGYG M G DAA E S RN T 402
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398205110 415 T HQ M KK MKL D D LK LM RD FLKI P IT DA VL EE npym P PYY K P EDND P RLQ Y MHE RR RE LGGY V P E RR SKYTEIAL P EKKTYD 494
Cdd:TIGR00759 403 A HQ V KK LEV D A LK NF RD RFEL P LS DA QV EE ---- L PYY H P GEGS P EVR Y LLA RR QA LGGY L P A RR TFAEHLTV P ALEFFG 478
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398205110 495 IAA KGSG VQ EV A TTM G FVR L L KD L IR DKE F G P R L VPI I PDEARTFGM DTF F PNAK IY N P N GQ H Y MS VD R D L LLAYKE DPT 574
Cdd:TIGR00759 479 ALL KGSG ER EV S TTM A FVR I L NK L LK DKE I G K R I VPI V PDEARTFGM EGL F RQIG IY S P H GQ T Y TP VD A D S LLAYKE SKD 558
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398205110 575 G T I IHV GINEAGA L A AFT A VGS SY S T Q GE IL IP I Y VF YSMFGFQR T GD AL W L A G DQ MV RGF VI GATAGRTTL T GEGLQH A 654
Cdd:TIGR00759 559 G Q I LQE GINEAGA M A SWI A AAT SY A T H GE PM IP F Y IY YSMFGFQR I GD LC W A A A DQ RA RGF LL GATAGRTTL N GEGLQH E 638
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398205110 655 DGHS PIL AAT N P AVVT YDPA YT YE IGH IM R DGL Q RMYG gth PDPN V M YY I TV Y NE PIQ QP AE PE N l DVD G V L R G I Y KLQE 734
Cdd:TIGR00759 639 DGHS LLQ AAT I P NCIA YDPA FA YE VAV IM E DGL R RMYG --- EQED V F YY V TV M NE NYV QP PM PE G - AEE G I L K G L Y RFET 714
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398205110 735 NDMPGV K S -- Q I L A SG VAVPWAL EA QK LLA E DWGV SA DVWSVTS WG EL R RDG IAADHF N MMN P EAPAQ V P YV TEK L SG A E 812
Cdd:TIGR00759 715 STEEKA K G hv Q L L G SG AIMRAVI EA AQ LLA A DWGV AS DVWSVTS FT EL A RDG HDVERW N LLH P TETPR V S YV AQV L NE A D 794
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398205110 813 G P FV A V TDY NHMVPDL IRPY I P GD Y A TLG A DGFG F SDTR AAA R R FF TI D GP SVV VRT L EQ LA KQ G KV D RGL V RQ AI E KY R 892
Cdd:TIGR00759 795 A P VI A S TDY VRAFAEQ IRPY V P RK Y V TLG T DGFG R SDTR ENL R H FF EV D AK SVV LAA L YA LA DD G EI D GDV V AD AI A KY G 874
....*..
gi 1398205110 893 LYDVT A G 899
Cdd:TIGR00759 875 IDPDK A N 881
AKGDH_not_PDH
TIGR03186 alpha-ketoglutarate dehydrogenase; Several bacterial species have a paralog to homodimeric ...
15-891
0e+00
alpha-ketoglutarate dehydrogenase; Several bacterial species have a paralog to homodimeric form of the pyruvate dehydrogenase E1 component (see model TIGR00759), often encoded next to L-methionine gamma-lyase gene (mdeA). The member from a strain of Pseudomonas putida was shown to act on alpha-ketobutyrate, which is produced by MdeA.This model serves as an exception model to TIGR00759, as other proteins hitting TIGR00759 should be identified as the pyruvate dehydrogenase E1 component.
Pssm-ID: 132230 [Multi-domain]
Cd Length: 889
Bit Score: 965.11
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398205110 15 D A DPQETAEW NES LDGVVA SQ G H ER GRDIMLS L LRRSKE L H L GV P MVPT T D Y L NTIA PEN EP AF PGD EET E R R YR A WI RW 94
Cdd:TIGR03186 5 D T DPQETAEW LDA LDGVVA HA G A ER AQYLLAQ L AAHAAR L G L AP P AAGA T P Y V NTIA VDQ EP PY PGD LQL E E R LA A IL RW 84
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398205110 95 NA AML V H RA Q R PGIGV GGHI S SYAS SSS L Y EVGFNHFFR GQDHPG GGD QIFV Q G H AS PGVYARAFLEG R L NES QL DGF RQ 174
Cdd:TIGR03186 85 NA LAM V V RA N R AYGEL GGHI A SYAS AAD L F EVGFNHFFR AAGDAS GGD LVYF Q P H SA PGVYARAFLEG F L SDA QL AHY RQ 164
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398205110 175 E K sh AG G GL S SYPHP R LMPDFWQFPT V SMG L GPINAIYQA QLN RYL T NRG IKDASDQQ VW A F L GDGEMDE V ES R G Q L QV A 254
Cdd:TIGR03186 165 E I -- AG P GL C SYPHP W LMPDFWQFPT G SMG I GPINAIYQA RFM RYL Q NRG LARTEGRK VW G F F GDGEMDE P ES I G A L SL A 242
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398205110 255 A N E G LDNL N FVINCNLQRLDGPVRGNG K II Q ELES F F R GAGWNVIKV I WG RE WD S L L A N D HD GAL RTLMNV T P DG D FQT Y 334
Cdd:TIGR03186 243 A R E R LDNL V FVINCNLQRLDGPVRGNG R II D ELES Q F A GAGWNVIKV L WG SD WD A L F A R D AT GAL ARAFAH T V DG Q FQT F 322
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398205110 335 KTE DGA FV R EN FF AR DP RALK LV E H M SD D D VWK L K RGGHD YN K V YAA FKA A SE H K G Q PTVILA H T I KG Y G L G KHFE GR NA 414
Cdd:TIGR03186 323 SAN DGA YN R AR FF GQ DP ALAA LV A H L SD E D IDR L R RGGHD AR K L YAA YDR A VR H E G R PTVILA K T M KG F G M G AIGQ GR MT 402
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398205110 415 THQ M KK MKLDD L KLM RD FLKI P IT DA VL E E npym PPY YKP EDNDPRLQ Y M H E RR RE LGGY V P E RR SKY T E - I A L P EKKTY 493
Cdd:TIGR03186 403 THQ Q KK LDVEA L LAF RD RFRL P LS DA DV E Q ---- LKF YKP DEDSAEMR Y L H A RR AA LGGY L P R RR TAA T H a L A V P ALPSW 478
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398205110 494 DIA A KGSGVQ E VA TTM GF VR L L KD L IR D K E F GPR L VPI IP DEARTFGM DTF F PNAK IY N P N GQ H Y MSV D RDLL L A Y K ED P 573
Cdd:TIGR03186 479 GRF A LDAEGK E MS TTM AI VR M L GA L LK D A E L GPR I VPI VA DEARTFGM ANL F RQVG IY S P L GQ R Y EPE D LGSM L Y Y R ED T 558
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398205110 574 T G T I IHV GI N EAGA LAAFT A VGS SYS TQGEILI P I Y VF YSMFGFQR T GD AL W L A G DQ MV RGF V IGAT A G R TTL T GEGLQH 653
Cdd:TIGR03186 559 D G Q I LEE GI S EAGA ISSWI A AAT SYS VHDLPML P F Y IY YSMFGFQR I GD LI W A A A DQ RA RGF L IGAT S G K TTL G GEGLQH 638
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398205110 654 A DG H S PIL A A T N P AVVTY DPA YT YE IGH I MRD G LQR M ygg THPDPNVM YY I TV Y NE PIQ QP AE PE N l DV D ---- G V L R G I 729
Cdd:TIGR03186 639 Q DG T S HLA A S T V P NCRAW DPA FA YE VAV I VDE G MRE M --- LERQRDEF YY L TV T NE NYA QP SL PE D - RL D avrr G I L K G M 714
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398205110 730 Y K L QENDMPGVKS Q I L A SG VAVPWALE A QK LL AE DWG VS A D VWSVTS WG EL R RDG I AA DHFNMMNPEAPAQV P Y V TEK L S 809
Cdd:TIGR03186 715 Y P L DPAALAAARV Q L L G SG AILGEVQA A AR LL RD DWG ID A A VWSVTS FT EL A RDG R AA ERAQRLGDAERPPS P H V AQA L G 794
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398205110 810 GAE GP FV A V TDY NHM VP D LIR P Y I P GD Y A TLG A DGFG F SDTRAA A R R FF TI D GP S V V VRT L EQ LA KQ G K V D R GL VRQAI E 889
Cdd:TIGR03186 795 ATQ GP VI A A TDY VRA VP E LIR A Y V P RR Y V TLG T DGFG R SDTRAA L R A FF EV D RA S I V IAA L QA LA DD G L V A R DV VRQAI A 874
..
gi 1398205110 890 K Y 891
Cdd:TIGR03186 875 R Y 876
TPP_E1_EcPDC_like
cd02017 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; ...
82-473
0e+00
Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative decarboxylation of pyruvate and the subsequent acetylation of coenzyme A to acetyl-CoA. The E1 component of PDC catalyzes the first step of the multistep process, using TPP and a divalent cation as cofactors. E. coli PDC is a homodimeric enzyme.
Pssm-ID: 238975 [Multi-domain]
Cd Length: 386
Bit Score: 670.17
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398205110 82 E E T ERR Y R AW IRWNA AML VHRA QRPGI G V GGHI SSY AS SSS LYEVGFNHFFR GQDHP GGGD QIFV QGHASPG V YARAFLE 161
Cdd:cd02017 1 L E I ERR I R SL IRWNA MAM VHRA NKKDL G I GGHI ATF AS AAT LYEVGFNHFFR ARGEG GGGD LVYF QGHASPG I YARAFLE 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398205110 162 GRL N E S QLD G FRQE ks HA GGGLSSYPHP R LMPDFW Q FPTVSMGLGPI N AIYQA QL NRYL TN RG I KD A SDQ Q VWAFLGDGE 241
Cdd:cd02017 81 GRL T E E QLD N FRQE -- VG GGGLSSYPHP W LMPDFW E FPTVSMGLGPI Q AIYQA RF NRYL ED RG L KD T SDQ K VWAFLGDGE 158
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398205110 242 MDE V ES R G QLQV AA N E G LDNL N FV I NCNLQRLDGPVRGNGKIIQELE SF FRGAGWNVIKVIWG RE WD S LLA N D HD GALR T 321
Cdd:cd02017 159 MDE P ES L G AIGL AA R E K LDNL I FV V NCNLQRLDGPVRGNGKIIQELE GI FRGAGWNVIKVIWG SK WD E LLA K D GG GALR Q 238
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398205110 322 L M NV T P DGD F QT Y K TE DGA F VRE N FF ARD P RALK LV EHM SD D D V W K L K RGGHD YN KVYAA F K A A S EHKG Q PTVILA H TIK 401
Cdd:cd02017 239 R M EE T V DGD Y QT L K AK DGA Y VRE H FF GKY P ELKA LV TDL SD E D L W A L N RGGHD PR KVYAA Y K K A V EHKG K PTVILA K TIK 318
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1398205110 402 GYGLG KHF EGRN AT HQ M KKM KL D D LK LM RD FLK IP IT D AV LEE N pymp PYYKP EDNDPRLQ Y M HERR RE LGG 473
Cdd:cd02017 319 GYGLG AAG EGRN HA HQ V KKM TE D E LK AL RD RFG IP VS D EQ LEE G ---- PYYKP PEGSEEIK Y L HERR HA LGG 386
PDH_E1_M
pfam17831 Pyruvate dehydrogenase E1 component middle domain; This entry represents one of the thiamin ...
484-714
4.76e-76
Pyruvate dehydrogenase E1 component middle domain; This entry represents one of the thiamin diphosphate-binding domains found in pyruvate dehydrogenase E1 component.
Pssm-ID: 465525 [Multi-domain]
Cd Length: 229
Bit Score: 247.72
E-value: 4.76e-76
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398205110 484 EI ALPEK K TYDIAAK GS GVQ E VA TTM G FVR L L KD L IR DK EF G PRL VPIIPDEARTFGM DTF F PNAK IY NPN GQ H Y MS VD R 563
Cdd:pfam17831 2 EI PDLDD K IFASQTG GS KGR E IS TTM A FVR I L NG L VK DK KI G KQV VPIIPDEARTFGM EGM F RQLG IY TSE GQ K Y EP VD K 81
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398205110 564 DLLLA Y K ED PT G T I IHV GI N EAGA LA A FT A VGS SYS TQGEI L I P I YV F YSMFGFQR T GD AL W L AGD QMV RGF VI G A TAGR 643
Cdd:pfam17831 82 GQIMF Y R ED KQ G Q I LEE GI S EAGA MS A WI A AAT SYS NHNTT L L P F YV Y YSMFGFQR I GD LA W A AGD MQA RGF LV G G TAGR 161
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1398205110 644 TTL T GEGLQH A DGHS P I L A A T N P AVVT YDP A Y TY E IGH I MR DGL Q RM YGGTH pdp N VM YY I TV Y NE PIQQ P 714
Cdd:pfam17831 162 TTL N GEGLQH Q DGHS H I Q A S T I P NCRS YDP T Y AH E VAV I VQ DGL K RM FADKE --- N CF YY L TV M NE NYEH P 229
TPP_TK
cd02012 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK ...
91-416
1.15e-22
Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the pentose phosphate pathway and provides precursors for nucleotide, aromatic amino acid and vitamin biosynthesis. In addition, the enzyme plays a central role in the Calvin cycle in plants. Typically, TKs are homodimers. They require TPP and divalent cations, such as magnesium ions, for activity.
Pssm-ID: 238970 [Multi-domain]
Cd Length: 255
Bit Score: 98.35
E-value: 1.15e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398205110 91 W IR WNAAML V HR A Q rpgigv G GH ISSYA S SSSLYE V GFNHFFR - GQDH P GGGDQ - I FV Q -- GHASP GV YA RAF L E G R L N E 166
Cdd:cd02012 2 R IR RLSIDM V QK A G ------ S GH PGGSL S AADILA V LYFKVLK y DPAD P KWPNR d R FV L sk GHASP AL YA VLA L A G Y L P E 75
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398205110 167 SQ L DG FRQ EK S HAG G glssyp HP - RLMPDFWQFP T V S M G L G PIN A IYQ A QLNRY L tnrgikd AS D QQ V WAF LGDGE MD E v 245
Cdd:cd02012 76 ED L KT FRQ LG S RLP G ------ HP e YGLTPGVEVT T G S L G Q G LSV A VGM A LAEKL L ------- GF D YR V YVL LGDGE LQ E - 141
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398205110 246 esr G Q ---- LQV A ANEG LDNL NFVINC N LQRL DGP VRG --- NGKIIQEL E S F frga GWNVI K V I wgrewdsllandhdga 318
Cdd:cd02012 142 --- G S vwea ASF A GHYK LDNL IAIVDS N RIQI DGP TDD ilf TEDLAKKF E A F ---- GWNVI E V D ---------------- 198
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398205110 319 lrtlmnvtpdgdfqtyktedgafvrenffardpralklvehmsdddvwklkrg GHD YNKVY AA FKA A SEH KG Q PT V I L A H 398
Cdd:cd02012 199 ----------------------------------------------------- GHD VEEIL AA LEE A KKS KG K PT L I I A K 225
330
....*....|....*...
gi 1398205110 399 TIKG Y G L g KHF E GRNAT H 416
Cdd:cd02012 226 TIKG K G V - PFM E NTAKW H 242
PRK05899
PRK05899 transketolase; Reviewed
148-436
2.51e-12
transketolase; Reviewed
Pssm-ID: 235639 [Multi-domain]
Cd Length: 586
Bit Score: 70.55
E-value: 2.51e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398205110 148 GH A S PGV Y ARAF L E G - R L NESQ L DG FRQ eksh A G ggl S SY P - HP rlmp DFWQF P T V SMGL GP I ----- NA IYQ A QLNR YL 220
Cdd:PRK05899 69 GH G S MLL Y SLLH L A G y D L SIDD L KN FRQ ---- L G --- S KT P g HP ---- EYGHT P G V ETTT GP L gqgla NA VGM A LAEK YL 137
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398205110 221 --- T NR GIK D AS D QQVWAFL GDG EMD E vesr G Q ---- LQV A ANEG L D NL NFVINC N - LQ r L DGP VR G ngkiiqele S F -- 290
Cdd:PRK05899 138 aal F NR PGL D IV D HYTYVLC GDG DLM E ---- G I shea CSL A GHLK L G NL IVIYDD N r IS - I DGP TE G --------- W F te 203
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398205110 291 ----- F RGA GW N VI K V I wgrewdsllandhdgalrtlmnvtpdgdfqtyktedgafvrenffardpralklvehmsdddv 365
Cdd:PRK05899 204 dvkkr F EAY GW H VI E V D --------------------------------------------------------------- 220
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1398205110 366 wklkrg GHD YNKVY AA FKA A SEHK g Q PT V I L A H TI K G Y G LG k HF EG RNAT H Q m KKMKLDDLKLMRDF L KIP 436
Cdd:PRK05899 221 ------ GHD VEAID AA IEE A KAST - K PT L I I A K TI I G K G AP - NK EG THKV H G - APLGAEEIAAAKKE L GWD 282
Transketolase_N
pfam00456 Transketolase, thiamine diphosphate binding domain; This family includes transketolase enzymes ...
148-456
1.91e-05
Transketolase, thiamine diphosphate binding domain; This family includes transketolase enzymes EC:2.2.1.1. and also partially matches to 2-oxoisovalerate dehydrogenase beta subunit EC:1.2.4.4. Both these enzymes utilize thiamine pyrophosphate as a cofactor, suggesting there may be common aspects in their mechanism of catalysis.
Pssm-ID: 395366 [Multi-domain]
Cd Length: 334
Bit Score: 47.77
E-value: 1.91e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398205110 148 GH A S PGV Y ARAF L E G - R L NESQ L DG FRQ EK S HAG G glssyp HP rlmp D F WQFPT V SMGL GP IN --------- AI YQAQ L N 217
Cdd:pfam00456 63 GH G S MLL Y SLLH L T G y D L SMED L KS FRQ LG S KTP G ------ HP ---- E F GHTAG V EVTT GP LG qgianavgm AI AERN L A 132
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398205110 218 - R Y lt NR GIK D AS D QQVWA FLGDG EMD E VE S RGQLQV A ANE GL D NL NFVINC N LQRL DG PVRGN gk IIQELESF F RGA GW 296
Cdd:pfam00456 133 a T Y -- NR PGF D IV D HYTYV FLGDG CLM E GV S SEASSL A GHL GL G NL IVFYDD N QISI DG ETKIS -- FTEDTAAR F EAY GW 208
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398205110 297 N VI K V I wgrewdsllandhdgalrtlmnvtpdgdfqtyktedgafvrenffardpralklvehmsdddvwklkr G GHD YN 376
Cdd:pfam00456 209 H VI E V E -------------------------------------------------------------------- D GHD VE 220
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398205110 377 KVY AA FKA A SEH K GQ PT V I LAH T IK GYG l GKHFE G RNAT H Q m KKMKL D DLKLMRDF L KI pitdavlee N PY m P P YYK P ED 456
Cdd:pfam00456 221 AIA AA IEE A KAE K DK PT L I KCR T VI GYG - SPNKQ G THDV H G - APLGA D EVAALKQK L GW --------- D PY - K P FEI P AE 288
TPP_enzymes
cd00568 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic ...
178-317
2.32e-05
Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and the branched chain alpha-keto acid dehydrogenase complexes.
Pssm-ID: 238318 [Multi-domain]
Cd Length: 168
Bit Score: 45.71
E-value: 2.32e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398205110 178 H A GGGLSSY P HP R LMPDFWQFPTVS MG L G PIN AI YQ A QLNR yltnrgikdas D QQ V WAFL GDG EMD ev ESRGQ L QV A ANE 257
Cdd:cd00568 23 S A YWAYRYL P LR R GRRFLTSTGFGA MG Y G LPA AI GA A LAAP ----------- D RP V VCIA GDG GFM -- MTGQE L AT A VRY 89
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1398205110 258 GL d NLNF V INC N -------- L Q RLDGPV R GN G KIIQE -- LESFFRGA G WNVIK V IWGREWDSL L -- A NDHD G 317
Cdd:cd00568 90 GL - PVIV V VFN N ggygtirm H Q EAFYGG R VS G TDLSN pd FAALAEAY G AKGVR V EDPEDLEAA L ae A LAAG G 160
Transket_pyr
smart00861 Transketolase, pyrimidine binding domain; Transketolase (TK) catalyzes the reversible transfer ...
578-703
7.08e-05
Transketolase, pyrimidine binding domain; Transketolase (TK) catalyzes the reversible transfer of a two-carbon ketol unit from xylulose 5-phosphate to an aldose receptor, such as ribose 5-phosphate, to form sedoheptulose 7-phosphate and glyceraldehyde 3- phosphate. This enzyme, together with transaldolase, provides a link between the glycolytic and pentose-phosphate pathways. TK requires thiamine pyrophosphate as a cofactor. In most sources where TK has been purified, it is a homodimer of approximately 70 Kd subunits. TK sequences from a variety of eukaryotic and prokaryotic sources show that the enzyme has been evolutionarily conserved. In the peroxisomes of methylotrophic yeast Hansenula polymorpha, there is a highly related enzyme, dihydroxy-acetone synthase (DHAS) (also known as formaldehyde transketolase), which exhibits a very unusual specificity by including formaldehyde amongst its substrates.
Pssm-ID: 214865 [Multi-domain]
Cd Length: 136
Bit Score: 43.63
E-value: 7.08e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398205110 578 I HV GI N E AGALAA ft A V G ss YSTQ G ei L I P IYVFYSM F g F Q R TG D ALWL AG DQMVRGF V I gatagrt TLT G E G LQHA DG - 656
Cdd:smart00861 18 I DT GI A E QAMVGF -- A A G -- LALH G -- L R P VVEIFFT F - F D R AK D QIRS AG ASGNVPV V F ------- RHD G G G GVGE DG p 83
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 1398205110 657 - H SP I ----- L A A T n P AVVTYD P AYTY E IGHIM R DGLQ rmyggt HPD P N V MYY 703
Cdd:smart00861 84 t H HS I edeal L R A I - P GLKVVA P SDPA E AKGLL R AAIR ------ DDG P V V IRL 129
PTZ00089
PTZ00089 transketolase; Provisional
145-301
7.94e-04
transketolase; Provisional
Pssm-ID: 173383 [Multi-domain]
Cd Length: 661
Bit Score: 43.12
E-value: 7.94e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398205110 145 FV -- Q GHAS PGV Y ARAF L E G R - L NESQ L DG FRQ EK S HAG G glssyp HP rlmp DFWQF P T V SMGL GP I ----- NA IYQ A QL 216
Cdd:PTZ00089 62 FV ls N GHAS ALL Y SMLH L T G Y d L SMED L KN FRQ LG S RTP G ------ HP ---- ERHIT P G V EVTT GP L gqgia NA VGL A IA 131
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398205110 217 NRY L T --- NR GIKDAS D QQ V WAFL GDG EMD E VE S RGQ L QV A ANE GL DN L NFVINC N LQRL DG P -- VRGNGKIIQEL E SF f 291
Cdd:PTZ00089 132 EKH L A akf NR PGHPIF D NY V YVIC GDG CLQ E GV S QEA L SL A GHL GL EK L IVLYDD N KITI DG N td LSFTEDVEKKY E AY - 210
170
....*....|
gi 1398205110 292 rga GW N VI K V 301
Cdd:PTZ00089 211 --- GW H VI E V 217
TktA
COG0021 Transketolase [Carbohydrate transport and metabolism]; Transketolase is part of the Pathway ...
372-443
2.07e-03
Transketolase [Carbohydrate transport and metabolism]; Transketolase is part of the Pathway/BioSystem: Pentose phosphate pathway
Pssm-ID: 439792 [Multi-domain]
Cd Length: 661
Bit Score: 41.92
E-value: 2.07e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1398205110 372 GHD YNKVY AA FK AA SEHKGQ PT V I LAH TI K GYG L g KHFE G RNAT H qmk KMK L -- DDLKLMRDF L KI P ----- IT D A V LE 443
Cdd:COG0021 218 GHD LEAID AA IE AA KAETDK PT L I ICK TI I GYG S - PNKQ G TAKA H --- GAP L ga EEIAATKEA L GW P pepfe VP D E V YA 292
Blast search parameters
Data Source:
Precalculated data, version = cdd.v.3.21
Preset Options: Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
