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Conserved domains on  [gi|1402578118|ref|WP_110479270|]
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DNA-directed RNA polymerase subunit beta [Avibacterium paragallinarum]

Protein Classification

DNA-directed RNA polymerase subunit beta( domain architecture ID 11478603)

DNA-directed RNA polymerase subunit beta catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates

Graphical summary

 Zoom to residue level

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List of domain hits

Name Accession Description Interval E-value
rpoB PRK00405
DNA-directed RNA polymerase subunit beta; Reviewed
1-1342 0e+00

DNA-directed RNA polymerase subunit beta; Reviewed


:

Pssm-ID: 234749 [Multi-domain]  Cd Length: 1112  Bit Score: 2244.97  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118    1 MGYSYTEKKRIRKDFGKRPQVLNVPYLLTIQLDSFDKFIQRD-PEGQQGLEAAFRSVFPIVSNNGNTELQYVSYRLGEPV 79
Cdd:PRK00405     1 MVYSYTGKKRIRKSFGKIKEVLELPNLLEIQLDSFDWFLQLDvPPEDEGLEEVFRSIFPIEDFNGNLSLEFVSYELGEPK 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118   80 FDVRECQIRGTTYAAPLRVKLRLVSYDkdaapgtIKDIKEQEVYMGEIPLMTDNGTFVINGTERVIVSQLHRSPGVFFDS 159
Cdd:PRK00405    81 YDVEECKERGLTYSAPLRVKLRLINKE-------TGEIKEQEVYMGDIPLMTENGTFIINGTERVIVSQLHRSPGVYFDH 153
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  160 DKGKThSSGKVLYNARIIPYRGSWLDFEFDPKDNLYARIDRRRKLPATIILRALNYTTEEILNLFFDKVIFQIEdnkllm 239
Cdd:PRK00405   154 DKDKT-SSGKLLYSARIIPYRGSWLEFEFDPKDILYVRIDRRRKLPVTVLLRALGYSDEEILDLFYEKEEFGKE------ 226
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  240 dlvperlrgetatfdivangktyvevgrritarhiralekdnvtqVEVPTEYIVGKVAAKDYVDLETGEVICPANGEISL 319
Cdd:PRK00405   227 ---------------------------------------------IEVPVEYLLGKVLAEDIVDEETGEVLAEANDEITE 261
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  320 EIlaklsqagyktietlftndldYGPYISDTLRVDPTTDRLSALVEIYRMMRPGEPPTKEAAEGLFDNLFFSPDRYDLSA 399
Cdd:PRK00405   262 EL---------------------DGPYIRNTLEKDPTSSREEALVEIYRRLRPGEPPTVEAARSLLENLFFDPKRYDLSK 320
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  400 VGRMKFNRSLGIEETTGSGILSKEDIVNVMRKLIDIRNGRGEVDDIDHLGNRRIRSVGEMAENQFRIGLVRVERAVKERL 479
Cdd:PRK00405   321 VGRYKLNKKLGLDEDEDVRVLTKEDIIATIKYLINLRNGKGEVDDIDHLGNRRVRSVGELLQNQFRIGLSRMERAVRERM 400
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  480 SLGDLEAVTPQDLINAKPISAAVKEFFGSSQLSQFMDQNNPLSEVTHKRRISALGPGGLTRERAGFEVRDVHATHYGRVC 559
Cdd:PRK00405   401 SLQDLDTLTPQDLINAKPVVAAIKEFFGSSQLSQFMDQTNPLSELTHKRRLSALGPGGLTRERAGFEVRDVHPTHYGRIC 480
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  560 PIETPEGPNIGLINSLAVYARTNDYGFLETPYRKVVNGQVTEEIEYLSAIEEGKYIIAQANSNLDDELRFTDTFVTCRgE 639
Cdd:PRK00405   481 PIETPEGPNIGLINSLATYARVNEYGFIETPYRKVVDGKVTDEIVYLTADEEDNYVIAQANAPLDEDGRFVDELVTAR-Y 559
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  640 HGESGLYRPEEIHYMDVSTQQIVSVAAALIPFLEHDDANRALMGANMQRQAVPTLRADKPLVGTGMEKPVALDSGVAVVA 719
Cdd:PRK00405   560 KGEFVLVPPEEVDYMDVSPKQVVSVAASLIPFLEHDDANRALMGSNMQRQAVPLLRPEAPLVGTGMERRVARDSGAVVVA 639
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  720 KRGGTIQYVDASRIVVKVneDETVAGEAGIDIYNLVKYTRSNQNTCINQIPCVKLGEPIERGEILADGPSTDLGELALGQ 799
Cdd:PRK00405   640 KRDGVVEYVDASRIVVRV--EELDPGEDGVDIYNLIKFQRSNQNTCINQRPIVKVGDRVEKGDVLADGPSTDNGELALGQ 717
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  800 NMRVAFMPWNGYNFEDSMLVSERVVQEDRFTTIHIQELSCVARDTKLGSEEITADIPNVGEAALSKLDESGIVYIGAEVK 879
Cdd:PRK00405   718 NVLVAFMPWNGYNFEDAILISERLVKEDVFTSIHIEEYEIEARDTKLGPEEITRDIPNVSEEALRNLDESGIVRIGAEVK 797
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  880 GGDILVGKVTPKGETQLTPEEKLLRAIFGEKASDVKDSSLRVPNSVSGTVIDVQVFTRdgvekdkraleieemqlkqakk 959
Cdd:PRK00405   798 PGDILVGKVTPKGETELTPEEKLLRAIFGEKARDVKDTSLRVPHGEEGTVIDVKVFTR---------------------- 855
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  960 dlveeleileaglfarvrnvlisggmdaaqldkldrtkwleqtlsdeekqsqleqlaeqyeelrkdfehklevkrgkIIQ 1039
Cdd:PRK00405   856 -----------------------------------------------------------------------------IEQ 858
                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118 1040 GDDLAPGVLKVVKVYLAVKRQIQPGDKMAGRHGNKGVISKINPVEDMPYDENGQPVDIVLNPLGVPSRMNIGQILETHLG 1119
Cdd:PRK00405   859 GDELPPGVNKLVKVYIAQKRKIQVGDKMAGRHGNKGVVSRILPVEDMPYLEDGTPVDIVLNPLGVPSRMNIGQILETHLG 938
                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118 1120 LAAKGIGDQInamikqkqdveklrgyiqkaydlgggsqkvdlstftdeevmrlaqnlrkglplATPVFDGAHEEEIKGLL 1199
Cdd:PRK00405   939 WAAKGLGIKF-----------------------------------------------------ATPVFDGAKEEEIKELL 965
                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118 1200 ELGGLPTSGQITLYDGRTGEKFERPVTVGYMYMLKLNHLVDDKMHARSTGSYSLVTQQPLGGKAQFGGQRFGEMEVWALE 1279
Cdd:PRK00405   966 EEAGLPEDGKTTLYDGRTGEPFDRPVTVGYMYMLKLHHLVDDKIHARSTGPYSLVTQQPLGGKAQFGGQRFGEMEVWALE 1045
                         1290      1300      1310      1320      1330      1340
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1402578118 1280 AYGAAYTLQEMLTVKSDDVNGRTKMYKNIVSGNQQMDPGTPESFNVIMKEIRSLGINIDLDEE 1342
Cdd:PRK00405  1046 AYGAAYTLQEMLTVKSDDVVGRTKVYEAIVKGENIPEPGIPESFNVLVKELQSLGLDVELLDE 1108
 
Name Accession Description Interval E-value
rpoB PRK00405
DNA-directed RNA polymerase subunit beta; Reviewed
1-1342 0e+00

DNA-directed RNA polymerase subunit beta; Reviewed


Pssm-ID: 234749 [Multi-domain]  Cd Length: 1112  Bit Score: 2244.97  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118    1 MGYSYTEKKRIRKDFGKRPQVLNVPYLLTIQLDSFDKFIQRD-PEGQQGLEAAFRSVFPIVSNNGNTELQYVSYRLGEPV 79
Cdd:PRK00405     1 MVYSYTGKKRIRKSFGKIKEVLELPNLLEIQLDSFDWFLQLDvPPEDEGLEEVFRSIFPIEDFNGNLSLEFVSYELGEPK 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118   80 FDVRECQIRGTTYAAPLRVKLRLVSYDkdaapgtIKDIKEQEVYMGEIPLMTDNGTFVINGTERVIVSQLHRSPGVFFDS 159
Cdd:PRK00405    81 YDVEECKERGLTYSAPLRVKLRLINKE-------TGEIKEQEVYMGDIPLMTENGTFIINGTERVIVSQLHRSPGVYFDH 153
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  160 DKGKThSSGKVLYNARIIPYRGSWLDFEFDPKDNLYARIDRRRKLPATIILRALNYTTEEILNLFFDKVIFQIEdnkllm 239
Cdd:PRK00405   154 DKDKT-SSGKLLYSARIIPYRGSWLEFEFDPKDILYVRIDRRRKLPVTVLLRALGYSDEEILDLFYEKEEFGKE------ 226
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  240 dlvperlrgetatfdivangktyvevgrritarhiralekdnvtqVEVPTEYIVGKVAAKDYVDLETGEVICPANGEISL 319
Cdd:PRK00405   227 ---------------------------------------------IEVPVEYLLGKVLAEDIVDEETGEVLAEANDEITE 261
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  320 EIlaklsqagyktietlftndldYGPYISDTLRVDPTTDRLSALVEIYRMMRPGEPPTKEAAEGLFDNLFFSPDRYDLSA 399
Cdd:PRK00405   262 EL---------------------DGPYIRNTLEKDPTSSREEALVEIYRRLRPGEPPTVEAARSLLENLFFDPKRYDLSK 320
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  400 VGRMKFNRSLGIEETTGSGILSKEDIVNVMRKLIDIRNGRGEVDDIDHLGNRRIRSVGEMAENQFRIGLVRVERAVKERL 479
Cdd:PRK00405   321 VGRYKLNKKLGLDEDEDVRVLTKEDIIATIKYLINLRNGKGEVDDIDHLGNRRVRSVGELLQNQFRIGLSRMERAVRERM 400
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  480 SLGDLEAVTPQDLINAKPISAAVKEFFGSSQLSQFMDQNNPLSEVTHKRRISALGPGGLTRERAGFEVRDVHATHYGRVC 559
Cdd:PRK00405   401 SLQDLDTLTPQDLINAKPVVAAIKEFFGSSQLSQFMDQTNPLSELTHKRRLSALGPGGLTRERAGFEVRDVHPTHYGRIC 480
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  560 PIETPEGPNIGLINSLAVYARTNDYGFLETPYRKVVNGQVTEEIEYLSAIEEGKYIIAQANSNLDDELRFTDTFVTCRgE 639
Cdd:PRK00405   481 PIETPEGPNIGLINSLATYARVNEYGFIETPYRKVVDGKVTDEIVYLTADEEDNYVIAQANAPLDEDGRFVDELVTAR-Y 559
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  640 HGESGLYRPEEIHYMDVSTQQIVSVAAALIPFLEHDDANRALMGANMQRQAVPTLRADKPLVGTGMEKPVALDSGVAVVA 719
Cdd:PRK00405   560 KGEFVLVPPEEVDYMDVSPKQVVSVAASLIPFLEHDDANRALMGSNMQRQAVPLLRPEAPLVGTGMERRVARDSGAVVVA 639
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  720 KRGGTIQYVDASRIVVKVneDETVAGEAGIDIYNLVKYTRSNQNTCINQIPCVKLGEPIERGEILADGPSTDLGELALGQ 799
Cdd:PRK00405   640 KRDGVVEYVDASRIVVRV--EELDPGEDGVDIYNLIKFQRSNQNTCINQRPIVKVGDRVEKGDVLADGPSTDNGELALGQ 717
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  800 NMRVAFMPWNGYNFEDSMLVSERVVQEDRFTTIHIQELSCVARDTKLGSEEITADIPNVGEAALSKLDESGIVYIGAEVK 879
Cdd:PRK00405   718 NVLVAFMPWNGYNFEDAILISERLVKEDVFTSIHIEEYEIEARDTKLGPEEITRDIPNVSEEALRNLDESGIVRIGAEVK 797
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  880 GGDILVGKVTPKGETQLTPEEKLLRAIFGEKASDVKDSSLRVPNSVSGTVIDVQVFTRdgvekdkraleieemqlkqakk 959
Cdd:PRK00405   798 PGDILVGKVTPKGETELTPEEKLLRAIFGEKARDVKDTSLRVPHGEEGTVIDVKVFTR---------------------- 855
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  960 dlveeleileaglfarvrnvlisggmdaaqldkldrtkwleqtlsdeekqsqleqlaeqyeelrkdfehklevkrgkIIQ 1039
Cdd:PRK00405   856 -----------------------------------------------------------------------------IEQ 858
                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118 1040 GDDLAPGVLKVVKVYLAVKRQIQPGDKMAGRHGNKGVISKINPVEDMPYDENGQPVDIVLNPLGVPSRMNIGQILETHLG 1119
Cdd:PRK00405   859 GDELPPGVNKLVKVYIAQKRKIQVGDKMAGRHGNKGVVSRILPVEDMPYLEDGTPVDIVLNPLGVPSRMNIGQILETHLG 938
                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118 1120 LAAKGIGDQInamikqkqdveklrgyiqkaydlgggsqkvdlstftdeevmrlaqnlrkglplATPVFDGAHEEEIKGLL 1199
Cdd:PRK00405   939 WAAKGLGIKF-----------------------------------------------------ATPVFDGAKEEEIKELL 965
                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118 1200 ELGGLPTSGQITLYDGRTGEKFERPVTVGYMYMLKLNHLVDDKMHARSTGSYSLVTQQPLGGKAQFGGQRFGEMEVWALE 1279
Cdd:PRK00405   966 EEAGLPEDGKTTLYDGRTGEPFDRPVTVGYMYMLKLHHLVDDKIHARSTGPYSLVTQQPLGGKAQFGGQRFGEMEVWALE 1045
                         1290      1300      1310      1320      1330      1340
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1402578118 1280 AYGAAYTLQEMLTVKSDDVNGRTKMYKNIVSGNQQMDPGTPESFNVIMKEIRSLGINIDLDEE 1342
Cdd:PRK00405  1046 AYGAAYTLQEMLTVKSDDVVGRTKVYEAIVKGENIPEPGIPESFNVLVKELQSLGLDVELLDE 1108
rpoB TIGR02013
DNA-directed RNA polymerase, beta subunit; This model describes orthologs of the beta subunit ...
8-1339 0e+00

DNA-directed RNA polymerase, beta subunit; This model describes orthologs of the beta subunit of Bacterial RNA polymerase. The core enzyme consists of two alpha chains, one beta chain, and one beta' subunit. [Transcription, DNA-dependent RNA polymerase]


Pssm-ID: 273928 [Multi-domain]  Cd Length: 1065  Bit Score: 1864.72  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118    8 KKRIRKDFGKRPQVLNVPYLLTIQLDSFDKFIQRDPE----GQQGLEAAFRSVFPIVSNNGNTELQYVSYRLGEPVFDVR 83
Cdd:TIGR02013    1 KKRIRIDFGKIPEVLEVPNLLEIQLDSYDWFLQQDTPpekrKEEGLEEVFKSIFPIEDYTGNIELEYLSYRLGEPKYSVE 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118   84 ECQIRGTTYAAPLRVKLRLVSYDKDaapgTIKDIKEQEVYMGEIPLMTDNGTFVINGTERVIVSQLHRSPGVFFDSDKGk 163
Cdd:TIGR02013   81 ECKERGLTYSAPLKVKLRLINKEED----GTKEIKEQDVYMGDIPLMTDRGTFIINGAERVVVSQLHRSPGVFFSSEKD- 155
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  164 THSSGKVLYNARIIPYRGSWLDFEFDPKDNLYARIDRRRKLPATIILRALNYTteeilnlffdkvifqiednkllmdlvp 243
Cdd:TIGR02013  156 TTKSGKVLFSARIIPYRGSWLEFETDKKDVLYVRIDRKRKLPATVLLRALGYT--------------------------- 208
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  244 erlrgetatfdivangktyvevgrritarhiralekdnvtqvevpteyivgkvaakdyvdletgevicpangeisleila 323
Cdd:TIGR02013      --------------------------------------------------------------------------------
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  324 klsqagyktIETLFTNDLDYGPYISDTLRVDPTTDRLSALVEIYRMMRPGEPPTKEAAEGLFDNLFFSPDRYDLSAVGRM 403
Cdd:TIGR02013  209 ---------IDTLILNRLGSGEYIRNTLRKDPTNSEEEALVEIYRKLRPGEPPTVEAARSLLENLFFDPKRYDLGRVGRY 279
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  404 KFNRSLGIEETTGSGILSKEDIVNVMRKLIDIRNGRGEVDDIDHLGNRRIRSVGEMAENQFRIGLVRVERAVKERLSLGD 483
Cdd:TIGR02013  280 KLNKKLGLDVPESIGVLTKEDIIATIKYLIKLRNGKGEIDDIDHLGNRRIRSVGELLQNQFRVGLARMERIVRERMSTQD 359
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  484 LEAVTPQDLINAKPISAAVKEFFGSSQLSQFMDQNNPLSEVTHKRRISALGPGGLTRERAGFEVRDVHATHYGRVCPIET 563
Cdd:TIGR02013  360 TDTLTPQDLINAKPISAAIKEFFGSSQLSQFMDQTNPLAELTHKRRLSALGPGGLTRERAGFEVRDVHPTHYGRICPIET 439
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  564 PEGPNIGLINSLAVYARTNDYGFLETPYRKVVNGQV--TEEIEYLSAIEEGKYIIAQANSNLDDELRFTDTFVTCRGEhG 641
Cdd:TIGR02013  440 PEGPNIGLINSLSTYARVNEYGFIETPYRKVKDGKVvvTDEIDYLTADEEDNYVIAQANAPLDENGRFVEDLVVARYR-G 518
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  642 ESGLYRPEEIHYMDVSTQQIVSVAAALIPFLEHDDANRALMGANMQRQAVPTLRADKPLVGTGMEKPVALDSGVAVVAKR 721
Cdd:TIGR02013  519 EITLVSPDQVDYMDVSPKQVVSVAASLIPFLEHDDANRALMGSNMQRQAVPLLRSEAPLVGTGMEAKVARDSGAVIVAKR 598
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  722 GGTIQYVDASRIVVKVNEDETvAGEAGIDIYNLVKYTRSNQNTCINQIPCVKLGEPIERGEILADGPSTDLGELALGQNM 801
Cdd:TIGR02013  599 GGVVEYVDAKRIVIRYDEDEE-EPDGGIDIYRLLKYQRSNQDTCINQRPIVSVGDRVEAGDVLADGPSTDLGELALGRNV 677
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  802 RVAFMPWNGYNFEDSMLVSERVVQEDRFTTIHIQELSCVARDTKLGSEEITADIPNVGEAALSKLDESGIVYIGAEVKGG 881
Cdd:TIGR02013  678 LVAFMPWNGYNYEDAILISERLVKDDVFTSIHIEEYEVEARDTKLGPEEITRDIPNVSEEALRNLDENGIVRIGAEVKAG 757
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  882 DILVGKVTPKGETQLTPEEKLLRAIFGEKASDVKDSSLRVPNSVSGTVIDVQVFTRDgvekdkraleieemqlkqakkdl 961
Cdd:TIGR02013  758 DILVGKVTPKGETELTPEEKLLRAIFGEKARDVRDTSLRVPPGVEGTVIDVKVFSRE----------------------- 814
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  962 veeleileaglfarvrnvlisggmdaaqldkldrtkwleqtlsdeekqsqleqlaeqyeelrkdfehklevkrgkiiQGD 1041
Cdd:TIGR02013  815 -----------------------------------------------------------------------------QGD 817
                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118 1042 DLAPGVLKVVKVYLAVKRQIQPGDKMAGRHGNKGVISKINPVEDMPYDENGQPVDIVLNPLGVPSRMNIGQILETHLGLA 1121
Cdd:TIGR02013  818 ELPPGVNKLVKVYIAQKRKIQVGDKMAGRHGNKGVVSKILPIEDMPFLEDGTPVDIVLNPLGVPSRMNIGQILETHLGWA 897
                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118 1122 AKGIGdqinamikqkqdveklrgyiqkaydlgggsqkvdlstftdeevmrlaqnlRKGLPLATPVFDGAHEEEIKGLLEL 1201
Cdd:TIGR02013  898 GKRLG--------------------------------------------------RKGVPIATPVFDGASEEEIKEYLEK 927
                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118 1202 GGLPTSGQITLYDGRTGEKFERPVTVGYMYMLKLNHLVDDKMHARSTGSYSLVTQQPLGGKAQFGGQRFGEMEVWALEAY 1281
Cdd:TIGR02013  928 AGLPRDGKVRLYDGRTGEQFDRPVTVGYMYMLKLHHLVDDKMHARSTGPYSLVTQQPLGGKAQFGGQRFGEMEVWALEAY 1007
                         1290      1300      1310      1320      1330
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1402578118 1282 GAAYTLQEMLTVKSDDVNGRTKMYKNIVSGNQQMDPGTPESFNVIMKEIRSLGINIDL 1339
Cdd:TIGR02013 1008 GAAYTLQEMLTVKSDDVVGRTKAYEAIVKGENVPEPGIPESFNVLIKELQSLGLDIEL 1065
RpoB COG0085
DNA-directed RNA polymerase, beta subunit/140 kD subunit [Transcription]; DNA-directed RNA ...
12-1342 0e+00

DNA-directed RNA polymerase, beta subunit/140 kD subunit [Transcription]; DNA-directed RNA polymerase, beta subunit/140 kD subunit is part of the Pathway/BioSystem: RNA polymerase


Pssm-ID: 439855 [Multi-domain]  Cd Length: 1001  Bit Score: 1630.20  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118   12 RKDFGKRPQVLNVPYLLTIQLDSFDKFIQrdpegqQGLEAAFRSVFPIVSNNGNTELQYVSYRLGEPVFDVRECQIRGTT 91
Cdd:COG0085      1 RWSFAKIKEPLELPNLLEIQLDSFNWFLE------EGLQEIFDEISPIEDFTGNLSLEFGDYRLGEPKYTPEECKERDLT 74
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118   92 YAAPLRVKLRLVSYDkdaapgtIKDIKEQEVYMGEIPLMTDNGTFVINGTERVIVSQLHRSPGVFFDSDKGKthsSGKVL 171
Cdd:COG0085     75 YAAPLYVKVRLVNKE-------TGEIKEQEVFMGDFPLMTDSGTFIINGTERVIVSQLVRSPGVYFVEEEDK---SGKDL 144
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  172 YNARIIPYRGSWLDFEFDPKDNLYARIDRRRKLPATIILRALNYTT-EEILNLFFDKVIFqiednkllmdlvperlrget 250
Cdd:COG0085    145 YSAKVIPSRGAWLEFETDKDGTIYVRIDRKRKIPVTVLLRALGLETdEEILEAFGDDPIQ-------------------- 204
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  251 atfdivangktyvevgrritarhiralekdnvtqvevpteyivgkvaakdyvdletgevicpangeisleilaklsqagy 330
Cdd:COG0085        --------------------------------------------------------------------------------
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  331 ktietlftndldygPYISDTLRVDPTTDRLSALVEIYRMMRPGEPPTKEAAEGLFDNLFFSPDRYDLSAVGRMKFNRSLG 410
Cdd:COG0085    205 --------------EYILATLEKDNTKTQEEALLEIYRKLRPGEPPTIERAEQLLDNLFFDPKRYDLAHVGRYKINKKLG 270
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  411 IEETTGSGILSKEDIVNVMRKLIDIRNGRGEVDDIDHLGNRRIRSVGEMAENQFRIGLVRVERAVKERLSLGDLEAVTPQ 490
Cdd:COG0085    271 LDVPPEDRVLTAEDIVATIKYLLELHLGEREPDDIDHLGNRRVRLVGELLQNQFRVGLSRMERVVRERMTTQDVEAITPQ 350
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  491 DLINAKPISAAVKEFFGSSQLSQFMDQNNPLSEVTHKRRISALGPGGLTRERAGFEVRDVHATHYGRVCPIETPEGPNIG 570
Cdd:COG0085    351 SLINIRPVVAAIKEFFGSSQLSQFMDQTNPLSELTHKRRLSALGPGGLSRERAGFEVRDVHPSHYGRMCPIETPEGPNIG 430
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  571 LINSLAVYARTNDYGFLETPYRKVVNGQVTEEIEYLSAIEEGKYIIAQANSNLDDELRFTDTFVTCRgEHGESGLYRPEE 650
Cdd:COG0085    431 LIGSLALYARVNEYGFIETPYRKVENGKVTDEIEYLTADEEENYYIAQANAPLDEDGNFLEERVLVR-YRGEEVLVPPEE 509
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  651 IHYMDVSTQQIVSVAAALIPFLEHDDANRALMGANMQRQAVPTLRADKPLvgtgmekpvaldsgvavvakrggtiqyvda 730
Cdd:COG0085    510 VDYMDVSPKQIVSVATSLIPFLEHDDANRALMGANMQRQAVPLLRPEAPL------------------------------ 559
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  731 srivvkvnedetvageagiDIYNLVKYTRSNQNTCINQIPCVKLGEPIERGEILADGPSTDLGELALGQNMRVAFMPWNG 810
Cdd:COG0085    560 -------------------LHYPLQKFQRSNQGTCINQRPIVRVGDRVEKGDVLADGPATDNGELALGQNLLVAFMPWEG 620
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  811 YNFEDSMLVSERVVQEDRFTTIHIQELSCVARDTKLGSEEITADIPNVGEAALSKLDESGIVYIGAEVKGGDILVGKVTP 890
Cdd:COG0085    621 YNYEDAIIISERLVKDDVLTSIHIEEYEIEARDTKLGPEEITRDIPNVSEEALRNLDEDGIIRIGAEVKGGDILVGKVTP 700
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  891 KGETQLTPEEKLLRAIFGEKASDVKDSSLRVPNSVSGTVIDVQVFTRDgvekdkraleieemqlkqakkdlveeleilea 970
Cdd:COG0085    701 KGETELTPEERLLRAIFGEKAREVRDTSLRVPHGEKGKVIDVKVFSRE-------------------------------- 748
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  971 glfarvrnvlisggmdaaqldkldrtkwleqtlsdeekqsqleqlaeqyeelrkdfehklevkrgkiiQGDDLAPGVLKV 1050
Cdd:COG0085    749 --------------------------------------------------------------------EGDELPPGVNKL 760
                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118 1051 VKVYLAVKRQIQPGDKMAGRHGNKGVISKINPVEDMPYDENGQPVDIVLNPLGVPSRMNIGQILETHLGLAAKgigdqin 1130
Cdd:COG0085    761 VRVYVAQKRKIEVGDKLAGRHGNKGVISRILPQEDMPFLEDGTPVDIVLNPLGVPSRMNVGQVLETHLGWAAA------- 833
                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118 1131 amikqkqdveklrgyiqkaydlgggsqkvdlstftdeevmrlaqnlRKGLPLATPVFDGAHEEEIKGLLELGGLPTSGQI 1210
Cdd:COG0085    834 ----------------------------------------------LLGRRVATPVFDGAPEEEIRELLEKAGLPPDGKE 867
                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118 1211 TLYDGRTGEKFERPVTVGYMYMLKLNHLVDDKMHARSTGSYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGAAYTLQEM 1290
Cdd:COG0085    868 VLYDGRTGEPFDNPVTVGYMYYLKLHHMVDDKIHARSTGPYSLITQQPLGGKAQFGGQRFGEMEVWALEAYGAAYTLQER 947
                         1290      1300      1310      1320      1330
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1402578118 1291 LTVKSDDVNGRTKMYKNIVSGNQQMDPGTPESFNVIMKEIRSLGINID-LDEE 1342
Cdd:COG0085    948 LTIKSDDVCGRVKVYEAIVKGENIPEPGIPESFKVLLKELQSLGLDVEvLSED 1000
RNA_pol_B_RPB2 cd00653
RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. ...
27-1340 0e+00

RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase complex contains two related members of this family, in each case they are the two largest subunits.The clamp is a mobile structure that grips DNA during elongation.


Pssm-ID: 238353 [Multi-domain]  Cd Length: 866  Bit Score: 880.75  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118   27 LLTIQLDSFDKFIQrdpegqQGLEAAFRSVFPIVS--NNGNTELQYVSYRLGEPV---------FDVRECQIRGTTYAAP 95
Cdd:cd00653      1 LVKQQIDSFNYFLN------VGLQEIVKSIPPITDtdDDGRLKLKFGDIYLGKPKveeggvtrkLTPNECRLRDLTYSAP 74
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118   96 LRVKLRLVSYDKDaapgtikDIKEQEVYMGEIPLMTD------------------------NGTFVINGTERVIVSQLHR 151
Cdd:cd00653     75 LYVDIRLTVNDKG-------KIKEQEVFIGEIPIMLRsklcnlngltpeeliklgecpldpGGYFIINGTEKVIINQEQR 147
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  152 SPGVFFDSDkgkthSSGKVLYNARIIP----YRGSWLDFEFDPKDNlyaridrrrklpatiilralnytteeilnlffdk 227
Cdd:cd00653    148 SPNVIIVED-----SKGKRIYTKTSIPsyspYRGSWLEVKSDKKKD---------------------------------- 188
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  228 vifqiednkllmdlvperlrgetatfdivangktyvevgrRITARHiralekdnvtqvevpteyivgkvaakdyvdletg 307
Cdd:cd00653    189 ----------------------------------------RIYVRI---------------------------------- 194
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  308 evicpangeisleilaklsqagyktietlftndldygPYIsdtlrvdpttDRLSALVEIYRmmrpgepptkeaaeglfdn 387
Cdd:cd00653    195 -------------------------------------DLK----------RQEEALKYIGK------------------- 208
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  388 lffspdrydlsavgrmKFnrslgieettgsgilskEDIVNVMRKLIDIRNGRGEVDDIDHLGNRRIRSVGEMAENQFRIG 467
Cdd:cd00653    209 ----------------RF-----------------EDLIYMIRKLILLVLGKGKLDDIDHLGNKRVRLAGELLQNLFRSG 255
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  468 LVRVERAVKERLS--LGDLEAVTPQDLINAKPISAAVKEFFGSSQ------------LSQFMDQNNPLSEVTHKRRISAl 533
Cdd:cd00653    256 LKRLEREVKEKLQkqLSKKKDLTPQLLINSKPITSGIKEFLATGNwgskrflmqrsgLSQVLDRLNPLSELSHKRRISS- 334
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  534 gpGGLTRERAGFEVRDVHATHYGRVCPIETPEGPNIGLINSLAVYARTNdyGFLETPYRKVVngqvteeieylsaieegk 613
Cdd:cd00653    335 --LGLFRERKGFEVRDLHPSHWGRICPIETPEGENCGLVKNLALMARIS--GRIERPYRIVE------------------ 392
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  614 yiiaqansnlddelrftdtfvtcrgehgesglyrpEEIHYMDVSTQQIVSVAAALIPFLEHDDANRALMGANMQRQAVPT 693
Cdd:cd00653    393 -----------------------------------KEVTHIEISPSQILSVAASLIPFPEHNQSPRNLYQSNMQKQAVGT 437
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  694 ----------------LRADKPLVGTGMEKPVALdsgvavvakrggtiqyvdasrivvkvnedetvageagidiynlvky 757
Cdd:cd00653    438 palnqqyrmdtklyllLYPQKPLVGTGIEEYIAF---------------------------------------------- 471
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  758 trsnqntcinqipcvklgepiergeiladgpstdlGELALGQNMRVAFMPWNGYNFEDSMLVSERVVQEDRFTTIHIQEL 837
Cdd:cd00653    472 -----------------------------------GELPLGQNAIVAVMSYSGYNFEDAIIINKSSVDRGFFRSIHYKKY 516
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  838 SCVARDTKLGSEEIT-ADIPNVGEAALSKLDESGIVYIGAEVKGGDILVGKVTPKGETQLTPeekllraIFGEKASDVKD 916
Cdd:cd00653    517 EIELRKTKNGPEEITrGDIPNVSEEKLKNLDEDGIIRPGARVEPGDILVGKITPKGETESTP-------IFGEKARDVRD 589
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  917 SSLRVPNSVSGTVIDVQVFTRDgvekdkraleieemqlkqakkdlveeleileaglfarvrnvlisggmdaaqldkldrt 996
Cdd:cd00653    590 TSLKYPGGEKGIVDDVKIFSRE---------------------------------------------------------- 611
                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  997 kwleqtlsdeekqsqleqlaeqyeelrkdfehklevkrgkiiqgddLAPGVLKVVKVYLAVKRQIQPGDKMAGRHGNKGV 1076
Cdd:cd00653    612 ----------------------------------------------LNDGGNKLVKVYIRQKRKPQIGDKFASRHGQKGV 645
                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118 1077 ISKINPVEDMPYDENGQPVDIVLNPLGVPSRMNIGQILETHLGLAAKgigdqinamikqkqdveklrgyiqkaydlgggs 1156
Cdd:cd00653    646 ISKILPQEDMPFTEDGIPPDIILNPHGFPSRMTIGQLLESLLGKAGA--------------------------------- 692
                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118 1157 qkvdlstftdeevmrlaqnlRKGLPLATPVFDGAHEEEIKGLLELGGLPTSGQITLYDGRTGEKFERPVTVGYMYMLKLN 1236
Cdd:cd00653    693 --------------------LLGKFGDATPFDGAEEEDISELLGEAGLNYYGKEVLYDGRTGEPLEAPIFVGPVYYQRLK 752
                         1290      1300      1310      1320      1330      1340      1350      1360
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118 1237 HLVDDKMHARSTGSYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGAAYTLQEMLTVKSDDVNGRTKMYKNIV------- 1309
Cdd:cd00653    753 HMVDDKIHARSTGPYSLLTRQPLKGRSRGGGQRFGEMERDALIAHGAAYLLQERLTIKSDDVVARVCVKCGIIlsanlcr 832
                         1370      1380      1390
                   ....*....|....*....|....*....|....
gi 1402578118 1310 ---SGNQQMDPGTPESFNVIMKEIRSLGINIDLD 1340
Cdd:cd00653    833 lckKGTNISKVGIPYAFKLLFQELQSMNIDPRLK 866
RNA_pol_Rpb2_6 pfam00562
RNA polymerase Rpb2, domain 6; RNA polymerases catalyze the DNA dependent polymerization of ...
718-1264 2.49e-164

RNA polymerase Rpb2, domain 6; RNA polymerases catalyze the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). This domain represents the hybrid binding domain and the wall domain. The hybrid binding domain binds the nascent RNA strand / template DNA strand in the Pol II transcription elongation complex. This domain contains the important structural motifs, switch 3 and the flap loop and binds an active site metal ion. This domain is also involved in binding to Rpb1 and Rpb3. Many of the bacterial members contain large insertions within this domain, as region known as dispensable region 2 (DRII).


Pssm-ID: 459854 [Multi-domain]  Cd Length: 371  Bit Score: 495.90  E-value: 2.49e-164
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  718 VAKRGGTIQYVDASRIVVKVNEdetvaGEAGIDIYNLVKYTRSNQNT---CINQIPCVKLGEpIERGeiladgpstDLGE 794
Cdd:pfam00562    1 VASLIPFVDHNQSPRNTYQCAM-----GKQAMGIYTLNKFYRSDQNTyvlCYPQKPLVKTGA-VEAG---------GFGE 65
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  795 LALGQNMRVAFMPWNGYNFEDSMLVSERVVQEDRFTTIHIQElsCVARDTKLG-SEEITADIPNVGEAALSKLDESGIVY 873
Cdd:pfam00562   66 LPLGQNAIVAVMSYTGYNQEDAIIINKSSVDRGFFTSIHIKE--IEARKTKLGpIEEITRDIPNVSEEALKKLDEDGIVR 143
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  874 IGAEVKGGDILVGKVtpkGETQLTpeeKLLRAIFGEKASDVKDSSLRVPNSVSGTVIDVQVFtrdgvekdkraleieemq 953
Cdd:pfam00562  144 VGAEVKPGDILVGKV---GPTELT---KLLRAIFGEKARDVKDTSLKVPPGEEGVVDDVIVF------------------ 199
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  954 lkqakkdlveeleileaglfarvrnvlisggmdaaqldkldrtkwleqtlsdeekqsqleqlaeqyeelrkdfehklevk 1033
Cdd:pfam00562      --------------------------------------------------------------------------------
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118 1034 rgkiiqgdDLAPGVLKVVKVYLAVKRQIQPGDKMAGRHGNKGVISKINPVEDMPYDENGQPVDIVLNPLGVPSRMNIGQI 1113
Cdd:pfam00562  200 --------ELPPGGIKMVKVYIRQKRKPEVGDKFASRHGQKGVVSRILPQEDMPFTEDGIPPDIILNPHGVPSRMTIGQL 271
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118 1114 LETHLGLAAKGigdqinamikqkqdveklrgyiqkaydlgggsqkvdlstftdeevmrlaqnlrKGLPLATPVFDGAHE- 1192
Cdd:pfam00562  272 LETHLGKAAAL-----------------------------------------------------LGVFVDATPFDGASTe 298
                          490       500       510       520       530       540       550
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1402578118 1193 -EEIKGLLELGGLPTSGQITLYDGRTGEKFERPVTVGYMYMLKLNHLVDDKMHARSTGSYSLVTQQPLGGKAQ 1264
Cdd:pfam00562  299 vEDIGELLEKAGYNYYGKEVLYDGRTGEPFEAPIFVGPIYYQKLKHMVDDKIHARSTGPYSLLTRQPLGGRAR 371
 
Name Accession Description Interval E-value
rpoB PRK00405
DNA-directed RNA polymerase subunit beta; Reviewed
1-1342 0e+00

DNA-directed RNA polymerase subunit beta; Reviewed


Pssm-ID: 234749 [Multi-domain]  Cd Length: 1112  Bit Score: 2244.97  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118    1 MGYSYTEKKRIRKDFGKRPQVLNVPYLLTIQLDSFDKFIQRD-PEGQQGLEAAFRSVFPIVSNNGNTELQYVSYRLGEPV 79
Cdd:PRK00405     1 MVYSYTGKKRIRKSFGKIKEVLELPNLLEIQLDSFDWFLQLDvPPEDEGLEEVFRSIFPIEDFNGNLSLEFVSYELGEPK 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118   80 FDVRECQIRGTTYAAPLRVKLRLVSYDkdaapgtIKDIKEQEVYMGEIPLMTDNGTFVINGTERVIVSQLHRSPGVFFDS 159
Cdd:PRK00405    81 YDVEECKERGLTYSAPLRVKLRLINKE-------TGEIKEQEVYMGDIPLMTENGTFIINGTERVIVSQLHRSPGVYFDH 153
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  160 DKGKThSSGKVLYNARIIPYRGSWLDFEFDPKDNLYARIDRRRKLPATIILRALNYTTEEILNLFFDKVIFQIEdnkllm 239
Cdd:PRK00405   154 DKDKT-SSGKLLYSARIIPYRGSWLEFEFDPKDILYVRIDRRRKLPVTVLLRALGYSDEEILDLFYEKEEFGKE------ 226
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  240 dlvperlrgetatfdivangktyvevgrritarhiralekdnvtqVEVPTEYIVGKVAAKDYVDLETGEVICPANGEISL 319
Cdd:PRK00405   227 ---------------------------------------------IEVPVEYLLGKVLAEDIVDEETGEVLAEANDEITE 261
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  320 EIlaklsqagyktietlftndldYGPYISDTLRVDPTTDRLSALVEIYRMMRPGEPPTKEAAEGLFDNLFFSPDRYDLSA 399
Cdd:PRK00405   262 EL---------------------DGPYIRNTLEKDPTSSREEALVEIYRRLRPGEPPTVEAARSLLENLFFDPKRYDLSK 320
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  400 VGRMKFNRSLGIEETTGSGILSKEDIVNVMRKLIDIRNGRGEVDDIDHLGNRRIRSVGEMAENQFRIGLVRVERAVKERL 479
Cdd:PRK00405   321 VGRYKLNKKLGLDEDEDVRVLTKEDIIATIKYLINLRNGKGEVDDIDHLGNRRVRSVGELLQNQFRIGLSRMERAVRERM 400
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  480 SLGDLEAVTPQDLINAKPISAAVKEFFGSSQLSQFMDQNNPLSEVTHKRRISALGPGGLTRERAGFEVRDVHATHYGRVC 559
Cdd:PRK00405   401 SLQDLDTLTPQDLINAKPVVAAIKEFFGSSQLSQFMDQTNPLSELTHKRRLSALGPGGLTRERAGFEVRDVHPTHYGRIC 480
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  560 PIETPEGPNIGLINSLAVYARTNDYGFLETPYRKVVNGQVTEEIEYLSAIEEGKYIIAQANSNLDDELRFTDTFVTCRgE 639
Cdd:PRK00405   481 PIETPEGPNIGLINSLATYARVNEYGFIETPYRKVVDGKVTDEIVYLTADEEDNYVIAQANAPLDEDGRFVDELVTAR-Y 559
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  640 HGESGLYRPEEIHYMDVSTQQIVSVAAALIPFLEHDDANRALMGANMQRQAVPTLRADKPLVGTGMEKPVALDSGVAVVA 719
Cdd:PRK00405   560 KGEFVLVPPEEVDYMDVSPKQVVSVAASLIPFLEHDDANRALMGSNMQRQAVPLLRPEAPLVGTGMERRVARDSGAVVVA 639
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  720 KRGGTIQYVDASRIVVKVneDETVAGEAGIDIYNLVKYTRSNQNTCINQIPCVKLGEPIERGEILADGPSTDLGELALGQ 799
Cdd:PRK00405   640 KRDGVVEYVDASRIVVRV--EELDPGEDGVDIYNLIKFQRSNQNTCINQRPIVKVGDRVEKGDVLADGPSTDNGELALGQ 717
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  800 NMRVAFMPWNGYNFEDSMLVSERVVQEDRFTTIHIQELSCVARDTKLGSEEITADIPNVGEAALSKLDESGIVYIGAEVK 879
Cdd:PRK00405   718 NVLVAFMPWNGYNFEDAILISERLVKEDVFTSIHIEEYEIEARDTKLGPEEITRDIPNVSEEALRNLDESGIVRIGAEVK 797
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  880 GGDILVGKVTPKGETQLTPEEKLLRAIFGEKASDVKDSSLRVPNSVSGTVIDVQVFTRdgvekdkraleieemqlkqakk 959
Cdd:PRK00405   798 PGDILVGKVTPKGETELTPEEKLLRAIFGEKARDVKDTSLRVPHGEEGTVIDVKVFTR---------------------- 855
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  960 dlveeleileaglfarvrnvlisggmdaaqldkldrtkwleqtlsdeekqsqleqlaeqyeelrkdfehklevkrgkIIQ 1039
Cdd:PRK00405   856 -----------------------------------------------------------------------------IEQ 858
                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118 1040 GDDLAPGVLKVVKVYLAVKRQIQPGDKMAGRHGNKGVISKINPVEDMPYDENGQPVDIVLNPLGVPSRMNIGQILETHLG 1119
Cdd:PRK00405   859 GDELPPGVNKLVKVYIAQKRKIQVGDKMAGRHGNKGVVSRILPVEDMPYLEDGTPVDIVLNPLGVPSRMNIGQILETHLG 938
                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118 1120 LAAKGIGDQInamikqkqdveklrgyiqkaydlgggsqkvdlstftdeevmrlaqnlrkglplATPVFDGAHEEEIKGLL 1199
Cdd:PRK00405   939 WAAKGLGIKF-----------------------------------------------------ATPVFDGAKEEEIKELL 965
                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118 1200 ELGGLPTSGQITLYDGRTGEKFERPVTVGYMYMLKLNHLVDDKMHARSTGSYSLVTQQPLGGKAQFGGQRFGEMEVWALE 1279
Cdd:PRK00405   966 EEAGLPEDGKTTLYDGRTGEPFDRPVTVGYMYMLKLHHLVDDKIHARSTGPYSLVTQQPLGGKAQFGGQRFGEMEVWALE 1045
                         1290      1300      1310      1320      1330      1340
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1402578118 1280 AYGAAYTLQEMLTVKSDDVNGRTKMYKNIVSGNQQMDPGTPESFNVIMKEIRSLGINIDLDEE 1342
Cdd:PRK00405  1046 AYGAAYTLQEMLTVKSDDVVGRTKVYEAIVKGENIPEPGIPESFNVLVKELQSLGLDVELLDE 1108
rpoB TIGR02013
DNA-directed RNA polymerase, beta subunit; This model describes orthologs of the beta subunit ...
8-1339 0e+00

DNA-directed RNA polymerase, beta subunit; This model describes orthologs of the beta subunit of Bacterial RNA polymerase. The core enzyme consists of two alpha chains, one beta chain, and one beta' subunit. [Transcription, DNA-dependent RNA polymerase]


Pssm-ID: 273928 [Multi-domain]  Cd Length: 1065  Bit Score: 1864.72  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118    8 KKRIRKDFGKRPQVLNVPYLLTIQLDSFDKFIQRDPE----GQQGLEAAFRSVFPIVSNNGNTELQYVSYRLGEPVFDVR 83
Cdd:TIGR02013    1 KKRIRIDFGKIPEVLEVPNLLEIQLDSYDWFLQQDTPpekrKEEGLEEVFKSIFPIEDYTGNIELEYLSYRLGEPKYSVE 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118   84 ECQIRGTTYAAPLRVKLRLVSYDKDaapgTIKDIKEQEVYMGEIPLMTDNGTFVINGTERVIVSQLHRSPGVFFDSDKGk 163
Cdd:TIGR02013   81 ECKERGLTYSAPLKVKLRLINKEED----GTKEIKEQDVYMGDIPLMTDRGTFIINGAERVVVSQLHRSPGVFFSSEKD- 155
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  164 THSSGKVLYNARIIPYRGSWLDFEFDPKDNLYARIDRRRKLPATIILRALNYTteeilnlffdkvifqiednkllmdlvp 243
Cdd:TIGR02013  156 TTKSGKVLFSARIIPYRGSWLEFETDKKDVLYVRIDRKRKLPATVLLRALGYT--------------------------- 208
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  244 erlrgetatfdivangktyvevgrritarhiralekdnvtqvevpteyivgkvaakdyvdletgevicpangeisleila 323
Cdd:TIGR02013      --------------------------------------------------------------------------------
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  324 klsqagyktIETLFTNDLDYGPYISDTLRVDPTTDRLSALVEIYRMMRPGEPPTKEAAEGLFDNLFFSPDRYDLSAVGRM 403
Cdd:TIGR02013  209 ---------IDTLILNRLGSGEYIRNTLRKDPTNSEEEALVEIYRKLRPGEPPTVEAARSLLENLFFDPKRYDLGRVGRY 279
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  404 KFNRSLGIEETTGSGILSKEDIVNVMRKLIDIRNGRGEVDDIDHLGNRRIRSVGEMAENQFRIGLVRVERAVKERLSLGD 483
Cdd:TIGR02013  280 KLNKKLGLDVPESIGVLTKEDIIATIKYLIKLRNGKGEIDDIDHLGNRRIRSVGELLQNQFRVGLARMERIVRERMSTQD 359
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  484 LEAVTPQDLINAKPISAAVKEFFGSSQLSQFMDQNNPLSEVTHKRRISALGPGGLTRERAGFEVRDVHATHYGRVCPIET 563
Cdd:TIGR02013  360 TDTLTPQDLINAKPISAAIKEFFGSSQLSQFMDQTNPLAELTHKRRLSALGPGGLTRERAGFEVRDVHPTHYGRICPIET 439
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  564 PEGPNIGLINSLAVYARTNDYGFLETPYRKVVNGQV--TEEIEYLSAIEEGKYIIAQANSNLDDELRFTDTFVTCRGEhG 641
Cdd:TIGR02013  440 PEGPNIGLINSLSTYARVNEYGFIETPYRKVKDGKVvvTDEIDYLTADEEDNYVIAQANAPLDENGRFVEDLVVARYR-G 518
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  642 ESGLYRPEEIHYMDVSTQQIVSVAAALIPFLEHDDANRALMGANMQRQAVPTLRADKPLVGTGMEKPVALDSGVAVVAKR 721
Cdd:TIGR02013  519 EITLVSPDQVDYMDVSPKQVVSVAASLIPFLEHDDANRALMGSNMQRQAVPLLRSEAPLVGTGMEAKVARDSGAVIVAKR 598
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  722 GGTIQYVDASRIVVKVNEDETvAGEAGIDIYNLVKYTRSNQNTCINQIPCVKLGEPIERGEILADGPSTDLGELALGQNM 801
Cdd:TIGR02013  599 GGVVEYVDAKRIVIRYDEDEE-EPDGGIDIYRLLKYQRSNQDTCINQRPIVSVGDRVEAGDVLADGPSTDLGELALGRNV 677
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  802 RVAFMPWNGYNFEDSMLVSERVVQEDRFTTIHIQELSCVARDTKLGSEEITADIPNVGEAALSKLDESGIVYIGAEVKGG 881
Cdd:TIGR02013  678 LVAFMPWNGYNYEDAILISERLVKDDVFTSIHIEEYEVEARDTKLGPEEITRDIPNVSEEALRNLDENGIVRIGAEVKAG 757
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  882 DILVGKVTPKGETQLTPEEKLLRAIFGEKASDVKDSSLRVPNSVSGTVIDVQVFTRDgvekdkraleieemqlkqakkdl 961
Cdd:TIGR02013  758 DILVGKVTPKGETELTPEEKLLRAIFGEKARDVRDTSLRVPPGVEGTVIDVKVFSRE----------------------- 814
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  962 veeleileaglfarvrnvlisggmdaaqldkldrtkwleqtlsdeekqsqleqlaeqyeelrkdfehklevkrgkiiQGD 1041
Cdd:TIGR02013  815 -----------------------------------------------------------------------------QGD 817
                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118 1042 DLAPGVLKVVKVYLAVKRQIQPGDKMAGRHGNKGVISKINPVEDMPYDENGQPVDIVLNPLGVPSRMNIGQILETHLGLA 1121
Cdd:TIGR02013  818 ELPPGVNKLVKVYIAQKRKIQVGDKMAGRHGNKGVVSKILPIEDMPFLEDGTPVDIVLNPLGVPSRMNIGQILETHLGWA 897
                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118 1122 AKGIGdqinamikqkqdveklrgyiqkaydlgggsqkvdlstftdeevmrlaqnlRKGLPLATPVFDGAHEEEIKGLLEL 1201
Cdd:TIGR02013  898 GKRLG--------------------------------------------------RKGVPIATPVFDGASEEEIKEYLEK 927
                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118 1202 GGLPTSGQITLYDGRTGEKFERPVTVGYMYMLKLNHLVDDKMHARSTGSYSLVTQQPLGGKAQFGGQRFGEMEVWALEAY 1281
Cdd:TIGR02013  928 AGLPRDGKVRLYDGRTGEQFDRPVTVGYMYMLKLHHLVDDKMHARSTGPYSLVTQQPLGGKAQFGGQRFGEMEVWALEAY 1007
                         1290      1300      1310      1320      1330
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1402578118 1282 GAAYTLQEMLTVKSDDVNGRTKMYKNIVSGNQQMDPGTPESFNVIMKEIRSLGINIDL 1339
Cdd:TIGR02013 1008 GAAYTLQEMLTVKSDDVVGRTKAYEAIVKGENVPEPGIPESFNVLIKELQSLGLDIEL 1065
RpoB COG0085
DNA-directed RNA polymerase, beta subunit/140 kD subunit [Transcription]; DNA-directed RNA ...
12-1342 0e+00

DNA-directed RNA polymerase, beta subunit/140 kD subunit [Transcription]; DNA-directed RNA polymerase, beta subunit/140 kD subunit is part of the Pathway/BioSystem: RNA polymerase


Pssm-ID: 439855 [Multi-domain]  Cd Length: 1001  Bit Score: 1630.20  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118   12 RKDFGKRPQVLNVPYLLTIQLDSFDKFIQrdpegqQGLEAAFRSVFPIVSNNGNTELQYVSYRLGEPVFDVRECQIRGTT 91
Cdd:COG0085      1 RWSFAKIKEPLELPNLLEIQLDSFNWFLE------EGLQEIFDEISPIEDFTGNLSLEFGDYRLGEPKYTPEECKERDLT 74
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118   92 YAAPLRVKLRLVSYDkdaapgtIKDIKEQEVYMGEIPLMTDNGTFVINGTERVIVSQLHRSPGVFFDSDKGKthsSGKVL 171
Cdd:COG0085     75 YAAPLYVKVRLVNKE-------TGEIKEQEVFMGDFPLMTDSGTFIINGTERVIVSQLVRSPGVYFVEEEDK---SGKDL 144
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  172 YNARIIPYRGSWLDFEFDPKDNLYARIDRRRKLPATIILRALNYTT-EEILNLFFDKVIFqiednkllmdlvperlrget 250
Cdd:COG0085    145 YSAKVIPSRGAWLEFETDKDGTIYVRIDRKRKIPVTVLLRALGLETdEEILEAFGDDPIQ-------------------- 204
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  251 atfdivangktyvevgrritarhiralekdnvtqvevpteyivgkvaakdyvdletgevicpangeisleilaklsqagy 330
Cdd:COG0085        --------------------------------------------------------------------------------
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  331 ktietlftndldygPYISDTLRVDPTTDRLSALVEIYRMMRPGEPPTKEAAEGLFDNLFFSPDRYDLSAVGRMKFNRSLG 410
Cdd:COG0085    205 --------------EYILATLEKDNTKTQEEALLEIYRKLRPGEPPTIERAEQLLDNLFFDPKRYDLAHVGRYKINKKLG 270
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  411 IEETTGSGILSKEDIVNVMRKLIDIRNGRGEVDDIDHLGNRRIRSVGEMAENQFRIGLVRVERAVKERLSLGDLEAVTPQ 490
Cdd:COG0085    271 LDVPPEDRVLTAEDIVATIKYLLELHLGEREPDDIDHLGNRRVRLVGELLQNQFRVGLSRMERVVRERMTTQDVEAITPQ 350
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  491 DLINAKPISAAVKEFFGSSQLSQFMDQNNPLSEVTHKRRISALGPGGLTRERAGFEVRDVHATHYGRVCPIETPEGPNIG 570
Cdd:COG0085    351 SLINIRPVVAAIKEFFGSSQLSQFMDQTNPLSELTHKRRLSALGPGGLSRERAGFEVRDVHPSHYGRMCPIETPEGPNIG 430
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  571 LINSLAVYARTNDYGFLETPYRKVVNGQVTEEIEYLSAIEEGKYIIAQANSNLDDELRFTDTFVTCRgEHGESGLYRPEE 650
Cdd:COG0085    431 LIGSLALYARVNEYGFIETPYRKVENGKVTDEIEYLTADEEENYYIAQANAPLDEDGNFLEERVLVR-YRGEEVLVPPEE 509
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  651 IHYMDVSTQQIVSVAAALIPFLEHDDANRALMGANMQRQAVPTLRADKPLvgtgmekpvaldsgvavvakrggtiqyvda 730
Cdd:COG0085    510 VDYMDVSPKQIVSVATSLIPFLEHDDANRALMGANMQRQAVPLLRPEAPL------------------------------ 559
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  731 srivvkvnedetvageagiDIYNLVKYTRSNQNTCINQIPCVKLGEPIERGEILADGPSTDLGELALGQNMRVAFMPWNG 810
Cdd:COG0085    560 -------------------LHYPLQKFQRSNQGTCINQRPIVRVGDRVEKGDVLADGPATDNGELALGQNLLVAFMPWEG 620
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  811 YNFEDSMLVSERVVQEDRFTTIHIQELSCVARDTKLGSEEITADIPNVGEAALSKLDESGIVYIGAEVKGGDILVGKVTP 890
Cdd:COG0085    621 YNYEDAIIISERLVKDDVLTSIHIEEYEIEARDTKLGPEEITRDIPNVSEEALRNLDEDGIIRIGAEVKGGDILVGKVTP 700
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  891 KGETQLTPEEKLLRAIFGEKASDVKDSSLRVPNSVSGTVIDVQVFTRDgvekdkraleieemqlkqakkdlveeleilea 970
Cdd:COG0085    701 KGETELTPEERLLRAIFGEKAREVRDTSLRVPHGEKGKVIDVKVFSRE-------------------------------- 748
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  971 glfarvrnvlisggmdaaqldkldrtkwleqtlsdeekqsqleqlaeqyeelrkdfehklevkrgkiiQGDDLAPGVLKV 1050
Cdd:COG0085    749 --------------------------------------------------------------------EGDELPPGVNKL 760
                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118 1051 VKVYLAVKRQIQPGDKMAGRHGNKGVISKINPVEDMPYDENGQPVDIVLNPLGVPSRMNIGQILETHLGLAAKgigdqin 1130
Cdd:COG0085    761 VRVYVAQKRKIEVGDKLAGRHGNKGVISRILPQEDMPFLEDGTPVDIVLNPLGVPSRMNVGQVLETHLGWAAA------- 833
                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118 1131 amikqkqdveklrgyiqkaydlgggsqkvdlstftdeevmrlaqnlRKGLPLATPVFDGAHEEEIKGLLELGGLPTSGQI 1210
Cdd:COG0085    834 ----------------------------------------------LLGRRVATPVFDGAPEEEIRELLEKAGLPPDGKE 867
                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118 1211 TLYDGRTGEKFERPVTVGYMYMLKLNHLVDDKMHARSTGSYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGAAYTLQEM 1290
Cdd:COG0085    868 VLYDGRTGEPFDNPVTVGYMYYLKLHHMVDDKIHARSTGPYSLITQQPLGGKAQFGGQRFGEMEVWALEAYGAAYTLQER 947
                         1290      1300      1310      1320      1330
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1402578118 1291 LTVKSDDVNGRTKMYKNIVSGNQQMDPGTPESFNVIMKEIRSLGINID-LDEE 1342
Cdd:COG0085    948 LTIKSDDVCGRVKVYEAIVKGENIPEPGIPESFKVLLKELQSLGLDVEvLSED 1000
PRK14844 PRK14844
DNA-directed RNA polymerase subunit beta/beta';
27-1341 0e+00

DNA-directed RNA polymerase subunit beta/beta';


Pssm-ID: 173305 [Multi-domain]  Cd Length: 2836  Bit Score: 1408.60  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118   27 LLTIQLDSFDKFIQRDpEGQQGLEAAFRSVFPIVSNNGNTELQYVSYRLGEPVFDVRECQIRGTTYAAPLRVKLRLV--- 103
Cdd:PRK14844    32 LVKVQKESYDSFTPKN-KGNERLEVIFHTIFPINDPLHRATIEFISCRVDDPKYDESECIKRGITFSAQVIASIRLVimq 110
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  104 -------------SYDKDAAPGTIKDIKEQEVYMGEIPLMTDNGTFVINGTERVIVSQLHRSPGVFFDSDKGKTHSSGKV 170
Cdd:PRK14844   111 dgisldeyksikeSGDHSKLATVIKSIEEQEVHFCELPMMTDKGTFIINGVEKVIVSQMHRSPGVFFDSDKGKTYNSGKL 190
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  171 LYNARIIPYRGSWLDFEFDPKDNLYARIDRRRKLPATIILRALNYTTEEILNLFFDKVIFQIEDNKLLMDLVPERLRGET 250
Cdd:PRK14844   191 IYSARVIPYRGSWLDIEFDVKDHLYFRIDRKRKLPISVLLKALGLSNNDILDRFYEKIKYIKHKDGWKVPFVPDKFKGVR 270
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  251 ATFDIV-ANGKTYVEVGRRITARHIRALEKDNVTQVEVPTEYIVGKVAAKDYVDLETGEVICPANGEISLEILAKLSQAG 329
Cdd:PRK14844   271 LPFDLMdVEGNVLLKANVRITSRLAKKLYDNELKEYLVPFDSICGLFLAEDLIDSASSTKILSAGESIKLEDIKKLELLS 350
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  330 YKTIETLFTNDLDYGPYISDTLRVDPTTDRLSALVEIYRMMRPGEPPTKEAAEGLFDNLFFSPDRYDLSAVGRMKFNRSL 409
Cdd:PRK14844   351 IDEISVLNIDNLSVGPYILNTLFLDENMSYQDALYEIYKVLRPGEVPVLEIVEEFFRNLFFSPEYYDLSNIGRLKLNSYL 430
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  410 GIEETTGSGILSKEDIVNVMRKLIDIRNGRGEVDDIDHLGNRRIRSVGEMAENQFRIGLVRVERAVKERLSLGDLEAVTP 489
Cdd:PRK14844   431 GLNYDEDLTVLTHEDIIEIVRKIVLLRDGQGSVDDIDHLGNRRVRSVGEFIENQFRTGLLKLERAVVDSMSTSSLDKVSP 510
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  490 QDLINAKPISAAVKEFFGSSQLSQFMDQNNPLSEVTHKRRISALGPGGLTRERAGFEVRDVHATHYGRVCPIETPEGPNI 569
Cdd:PRK14844   511 SDFINPKVLTNVLRDFFNSSQLSQFMDQTNPLSEITHKRRLSALGPGGLTRERAGFEVRDVHPTHYGRICPIETPEGQNI 590
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  570 GLINSLAVYARTNDYGFLETPYRKVVNGQVTEEIEYLSAIEEGKYIIAQANSNLDDELRFTDTFVTCRgEHGESGLYRPE 649
Cdd:PRK14844   591 GLINSLAIYARINKYGFIESPYRKVVNRVVTDQIEYLSAIDEGLYYIADTSAKLDENNCFVDDMLYCR-YAGSFVMVSSD 669
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  650 EIHYMDVSTQQIVSVAAALIPFLEHDDANRALMGANMQRQAVPTLRADKPLVGTGMEKPVALDSGVAVVAKRGGTIQYVD 729
Cdd:PRK14844   670 QVSYIDVSPKQVISVAASLIPFLENDDANRALMGSNMQRQAVPLLKPTAPLVATGMESFVASGSGAVVLAKRDGIVDSSD 749
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  730 ASRIVVKVNEDETVaGEAGIDIYNLVKYTRSNQNTCINQIPCVKLGEPIERGEILADGPSTDLGELALGQNMRVAFMPWN 809
Cdd:PRK14844   750 SNSIVIRAFDKERV-NYLDVDIYHLRKFQRSNHNTCINQKPLVCVGDYVKEGDVIADGPAINSGELALGQNLLVAFMSWQ 828
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  810 GYNFEDSMLVSERVVQEDRFTTIHIQELSCVARDTKLGSEEITADIPNVGEAALSKLDESGIVYIGAEVKGGDILVGKVT 889
Cdd:PRK14844   829 GYNFEDSIIISSEVVKKDLFTSIHIEEFECVVHDTPLGSEKITRAIPGVNEENLYHLDDSGIVKIGTRVGPGYILVGKVT 908
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  890 PKGETQLTPEEKLLRAIFGEKASDVKDSSLRVPNSVSGTVIDVQVFTRDGVEKDKRALEIEEMQLKQAKKDLVEELEILE 969
Cdd:PRK14844   909 PKPSLSLPPETKLLMTIFGEKSFDCADSSLYTSPDVEGTVIDVQVFTRRGVEENERALLIKQKEINDFEKERDYIINVTS 988
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  970 AGLFARVRNVLI-SGGMDAAQLDKLDRTKWLEQTLSDeekqsqlEQLAEQYEELRKDFEHKL-------EVKRGKIIQGD 1041
Cdd:PRK14844   989 EYFYDELKKLLInSGSQDREKFDSIEREQWWGIGLKN-------QSISEQVKSLKKDFDEKVshaiaqfKRKVEKLHEGY 1061
                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118 1042 DLAPGVLKVVKVYLAVKRQIQPGDKMAGRHGNKGVISKINPVEDMPYDENGQPVDIVLNPLGVPSRMNIGQILETHLGLA 1121
Cdd:PRK14844  1062 DLPQGVSMSVKVFIAVKHSLQPGDKMAGRHGNKGVISRVVPVEDMPYLEDGTPVDIILNPLGVPSRMNVGQILETHVGWA 1141
                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118 1122 AKGIG----------------------------------------------------------------DQINAMIKQ-- 1135
Cdd:PRK14844  1142 CKKLGekvgnildeinkiksafckgirslnddnftkfaaayldnkkienidddeitasvlntpnknalnDELNELVENyl 1221
                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118 1136 ---KQDVEKLRGYIQKAYDLGGG-SQKVDLSTFTDEEVMRLAQNLRKGLPLATPVFDGAHEEEIKGLLELGGLPTSGQIT 1211
Cdd:PRK14844  1222 nscKSAYSNLRNFLIEVYSCGSNvSICNNIRDISDNNLIEFARKLRDGIPVAAPVFEGPKDEQIAKLFELAGLDNSGQAV 1301
                         1290      1300      1310      1320      1330      1340      1350      1360
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118 1212 LYDGRTGEKFERPVTVGYMYMLKLNHLVDDKMHARSTGSYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGAAYTLQEML 1291
Cdd:PRK14844  1302 LYDGCSGEKFDRKVTVGYMYMLKLHHLVDGKIHARSVGPYSLVTQQPLGGKSHFGGQRFGEMECWALQAYGAAYTLQEML 1381
                         1370      1380      1390      1400      1410
                   ....*....|....*....|....*....|....*....|....*....|
gi 1402578118 1292 TVKSDDVNGRTKMYKNIVSGNQQMDPGTPESFNVIMKEIRSLGINIDLDE 1341
Cdd:PRK14844  1382 TVKSDDINGRVKIYESIIKGDSNFECGIPESFNVMIKELRSLCLNVDLKQ 1431
PRK09603 PRK09603
DNA-directed RNA polymerase subunit beta/beta';
8-1339 0e+00

DNA-directed RNA polymerase subunit beta/beta';


Pssm-ID: 181983 [Multi-domain]  Cd Length: 2890  Bit Score: 1401.97  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118    8 KKRIRKDFGKRPQVLNVPYLLTIQLDSFDKFIQRDPEGQQGLEAAFRSVFPIVSNNGNTELQYVSYRLGEPVFDVRECQI 87
Cdd:PRK09603     8 KNRLRADFTKTPTDLEVPNLLLLQRDSYDSFLYSKDGKESGIEKVFKSIFPIQDEHNRITLEYAGCEFGKSKYTVREAME 87
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118   88 RGTTYAAPLRVKLRLVSYDKDAAPG---TIKDIKEQEVYMGEIPLMTDNGTFVINGTERVIVSQLHRSPGVFFDSDKGKT 164
Cdd:PRK09603    88 RGITYSIPLKIKVRLILWEKDTKSGeknGIKDIKEQSIFIREIPLMTERTSFIINGVERVVVNQLHRSPGVIFKEEESST 167
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  165 hSSGKVLYNARIIPYRGSWLDFEFDPKDNLYARIDRRRKLPATIILRALNYTTEEILNLFFDKVIFQIEDNKLLMDLVPE 244
Cdd:PRK09603   168 -SLNKLIYTGQIIPDRGSWLYFEYDSKDVLYARINKRRKVPVTILFRAMDYQKQDIIKMFYPLVKVRYENDKYLIPFASL 246
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  245 RLRGEtATFDIV-ANGKTYVEVGRRITARHIRALEKDNVTQVEVPTEYIVGKVAAKDYVDLEtgevicpangEISLEILA 323
Cdd:PRK09603   247 DANQR-MEFDLKdPQGKIILLAGKKLTSRKIKELKENHLEWVEYPMDILLNRHLAEPVMVGK----------EVLLDMLT 315
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  324 KLSQAGYKTI------ETLFTNDLDYGPYIS---------DTLRVDPTTDRLS-----ALVEIYRMMRPGEPPTKEAAEG 383
Cdd:PRK09603   316 QLDKNKLEKIhdlgvqEFVIINDLALGHDASiihsfsadsESLKLLKQTEKIDdenalAAIRIHKVMKPGDPVTTEVAKQ 395
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  384 LFDNLFFSPDRYDLSAVGRMKFNRSLGIEETTGSGILSKEDIVNVMRKLIDIRNGRGEVDDIDHLGNRRIRSVGEMAENQ 463
Cdd:PRK09603   396 FVKKLFFDPERYDLTMVGRMKMNHKLGLHVPDYITTLTHEDIITTVKYLMKIKNNQGKIDDRDHLGNRRIRAVGELLANE 475
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  464 FRIGLVRVERAVKERLSL--GDLEAVTPQDLINAKPISAAVKEFFGSSQLSQFMDQNNPLSEVTHKRRISALGPGGLTRE 541
Cdd:PRK09603   476 LHSGLVKMQKTIKDKLTTmsGAFDSLMPHDLVNSKMITSTIMEFFMGGQLSQFMDQTNPLSEVTHKRRLSALGEGGLVKD 555
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  542 RAGFEVRDVHATHYGRVCPIETPEGPNIGLINSLAVYARTNDYGFLETPYRKVVNGQVTEEIEYLSAIEEGKYIIAQANS 621
Cdd:PRK09603   556 RVGFEARDVHPTHYGRICPIETPEGQNIGLINTLSTFTRVNDLGFIEAPYKKVVDGKVVGETIYLTAIQEDSHIIAPAST 635
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  622 NLDDELRFTDTFVTCRGEhGESGLYRPEEIHYMDVSTQQIVSVAAALIPFLEHDDANRALMGANMQRQAVPTLRADKPLV 701
Cdd:PRK09603   636 PIDEEGNILGDLIETRVE-GEIVLNEKSKVTLMDLSSSMLVGVAASLIPFLEHDDANRALMGTNMQRQAVPLLRSDAPIV 714
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  702 GTGMEKPVALDSGVAVVAKRGGTIQYVDASRIVVkVNEDETvagEAGIDIYNLVKYTRSNQNTCINQIPCVKLGEPIERG 781
Cdd:PRK09603   715 GTGIEKIIARDSWGAIKANRAGVVEKIDSKNIYI-LGEGKE---EAYIDAYSLQKNLRTNQNTSFNQVPIVKVGDKVEAG 790
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  782 EILADGPSTDLGELALGQNMRVAFMPWNGYNFEDSMLVSERVVQEDRFTTIHIQELSCVARDTKLGSEEITADIPNVGEA 861
Cdd:PRK09603   791 QIIADGPSMDRGELALGKNVRVAFMPWNGYNFEDAIVVSERITKDDIFTSTHIYEKEVDARELKHGVEEFTADIPDVKEE 870
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  862 ALSKLDESGIVYIGAEVKGGDILVGKVTPKGETQLTPEEKLLRAIFGEKASDVKDSSLRVPNSVSGTVIDVQVFTRDGVE 941
Cdd:PRK09603   871 ALAHLDESGIVKVGTYVSAGMILVGKTSPKGEIKSTPEERLLRAIFGDKAGHVVNKSLYCPPSLEGTVIDVKVFTKKGYE 950
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  942 KDKRALEIEEMQLKQAKKDLVEELEILEAGLFARVRNVL----------ISGGM--DAAQLDKLDRTKWLEQTLS----- 1004
Cdd:PRK09603   951 KDARVLSAYEEEKAKLDMEHFDRLTMLNREELLRVSSLLsqaileepfsHNGKDykEGDQIPKEEIASINRFTLAslvkk 1030
                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118 1005 -DEEKQSQLEQLAEQYEELRKDFEHKLEVKRgKIIQGDDLAP-GVLKVVKVYLAVKRQIQPGDKMAGRHGNKGVISKINP 1082
Cdd:PRK09603  1031 ySKEVQNHYEITKNNFLEQKKVLGEEHEEKL-SILEKDDILPnGVIKKVKLYIATKRKLKVGDKMAGRHGNKGIVSNIVP 1109
                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118 1083 VEDMPYDENGQPVDIVLNPLGVPSRMNIGQILETHLGLAAKGIGDQINAMIKQ--KQDVEKLRGY---IQKAYDLGGGSQ 1157
Cdd:PRK09603  1110 VADMPYTADGEPVDIVLNPLGVPSRMNIGQILEMHLGLVGKEFGKQIASMLEDktKDFAKELRAKmleIANAINEKDPLT 1189
                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118 1158 KVDLSTFTDEEVMRLAQNLRKGLPLATPVFDGAHEEEIKGLLELGGLPTSGQITLYDGRTGEKFERPVTVGYMYMLKLNH 1237
Cdd:PRK09603  1190 IHALENCSDEELLEYAKDWSKGVKMAIPVFEGISQEKFYKLFELAKIAMDGKMDLYDGRTGEKMRERVNVGYMYMIKLHH 1269
                         1290      1300      1310      1320      1330      1340      1350      1360
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118 1238 LVDDKMHARSTGSYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGAAYTLQEMLTVKSDDVNGRTKMYKNIVSGNQQMDP 1317
Cdd:PRK09603  1270 LVDEKVHARSTGPYSLVTHQPVGGKALFGGQRFGEMEVWALEAYGAAHTLKEMLTIKSDDIRGRENAYRAIAKGEQVGES 1349
                         1370      1380
                   ....*....|....*....|..
gi 1402578118 1318 GTPESFNVIMKEIRSLGINIDL 1339
Cdd:PRK09603  1350 EIPETFYVLTKELQSLALDINI 1371
rpoB CHL00001
RNA polymerase beta subunit
25-1338 0e+00

RNA polymerase beta subunit


Pssm-ID: 214330 [Multi-domain]  Cd Length: 1070  Bit Score: 1057.97  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118   25 PYLLTIQLDSFDKFIQrdpegqQGLEAAFRSVFPIVSNNGNTELQYVS--YRLGEPVFDVRECQIRGTTYAAPLRVKLRL 102
Cdd:CHL00001    13 PGFNQIQFEGFCRFID------QGLTEELSKFPKIEDTDQEIEFQLFVetYQLVEPLIKERDAVYESLTYSSELYVPAGL 86
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  103 VSYDKdaapgtiKDIKEQEVYMGEIPLMTDNGTFVINGTERVIVSQLHRSPGVFFDSDKGKthsSGKVLYNARIIPYRGS 182
Cdd:CHL00001    87 IWKKS-------RDMQEQTVFIGNIPLMNSLGTFIINGIYRVVINQILRSPGIYYRSELDH---NGISVYTGTIISDWGG 156
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  183 WLDFEFDPKDNLYARIDRRRKLPATIILRALNYTTEEIL-NLFFDKVIFQIEDNKllmdlvperlrgetatfdivangkt 261
Cdd:CHL00001   157 RLELEIDRKARIWARVSRKQKISILVLLSAMGLNLREILdNVCYPEIFLSFLNDK------------------------- 211
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  262 yvevgrritarhiralEKDNVTQVEvpteyivgkvaakdyvdletgevicpangeisleilaklsqagyktietlftndl 341
Cdd:CHL00001   212 ----------------EKKKIGSKE------------------------------------------------------- 220
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  342 dygpyisdtlrvdpttdrlSALVEIYRMM--RPGEPPTKEAAEGLFDNLFFSPdRYDLSAVGRMKFNRSLGIEETTGSGI 419
Cdd:CHL00001   221 -------------------NAILEFYQQFacVGGDPVFSESLCKELQKKFFQQ-RCELGRIGRRNMNRKLNLDIPENNTF 280
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  420 LSKEDIVNVMRKLIDIRNGRGEVDDIDHLGNRRIRSVGEMAENQFRIGLVRVERAVKERLS--LGDLEAVTPQDLINAKP 497
Cdd:CHL00001   281 LLPQDVLAAADYLIGMKFGMGTLDDIDHLKNKRIRSVADLLQDQFGLALNRLENAVRGTICgaIRRKLIPTPQNLVTSTP 360
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  498 ISAAVKEFFGSSQLSQFMDQNNPLSEVTHKRRISALGPGGLTRERAGFEVRDVHATHYGRVCPIETPEGPNIGLINSLAV 577
Cdd:CHL00001   361 LTTTYESFFGSHPLSQFLDQTNPLTEIVHGRKLSSLGPGGLTGRTASFRVRDIHPSHYGRICPIDTSEGINAGLIGSLAI 440
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  578 YARTNDYGFLETPYRKVVNGQVTEEIEYLSAIEEGKYIIAQANSNLDDE---------LRFTDTFVTcrgehgesglYRP 648
Cdd:CHL00001   441 HARIGHWGSLESPFYEISERSKEERMVYLSPSEDEYYMIAAGNSLALNQgiqeeqvvpARYRQEFLT----------IAW 510
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  649 EEIHYMDVSTQQIVSVAAALIPFLEHDDANRALMGANMQRQAVPTLRADKPLVGTGMEKPVALDSGVAVVAKRGGTIQYV 728
Cdd:CHL00001   511 EQIHLRSIFPFQYFSIGASLIPFLEHNDANRALMGSNMQRQAVPLSRSEKCIVGTGLERQVALDSGVVAIAEHEGKIIYT 590
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  729 DASRIVVKVNEDETvageagidIYNLVKYTRSNQNTCINQIPCVKLGEPIERGEILADGPSTDLGELALGQNMRVAFMPW 808
Cdd:CHL00001   591 DTDKIILSGNGDTL--------SIPLVMYQRSNKNTCMHQKPQVRRGKCVKKGQILADGAATVGGELALGKNVLVAYMPW 662
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  809 NGYNFEDSMLVSERVVQEDRFTTIHIQELSCVARDTKLGSEEITADIPNVGEAALSKLDESGIVYIGAEVKGGDILVGKV 888
Cdd:CHL00001   663 EGYNFEDAVLISERLVYEDIYTSFHIRKYEIQTHVTSQGPERITKEIPHLEAHLLRNLDKNGIVMLGSWVETGDILVGKL 742
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  889 TPK--GETQLTPEEKLLRAIFGEKASDVKDSSLRVPNSVSGTVIDVqvftrdgvekdkraleieemqlkqakkdlveele 966
Cdd:CHL00001   743 TPQeaEESSYAPEGRLLRAIFGIQVSTSKETCLKLPIGGRGRVIDV---------------------------------- 788
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  967 ileaglfarvrnvlisggmdaaqldkldrtKWleqtlsdeekqsqleqlaeqyeelrkdfehklevkrgkiIQGDDLAPG 1046
Cdd:CHL00001   789 ------------------------------RW---------------------------------------IQKKGGSSY 799
                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118 1047 VLKVVKVYLAVKRQIQPGDKMAGRHGNKGVISKINPVEDMPYDENGQPVDIVLNPLGVPSRMNIGQILETHLGLAAkgig 1126
Cdd:CHL00001   800 NPETIHVYILQKREIQVGDKVAGRHGNKGIISKILPRQDMPYLQDGTPVDMVLNPLGVPSRMNVGQIFECLLGLAG---- 875
                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118 1127 dqinamikqkqdveklrGYIQKAYDLgggsqkvdlstftdeevmrlaqnlrkglplaTPvFDGAHEEEIKGLLELGGLPT 1206
Cdd:CHL00001   876 -----------------DLLNRHYRI-------------------------------AP-FDERYEQEASRKLVFSELYE 906
                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118 1207 SGQIT---------------LYDGRTGEKFERPVTVGYMYMLKLNHLVDDKMHARSTGSYSLVTQQPLGGKAQFGGQRFG 1271
Cdd:CHL00001   907 ASKQTanpwvfepeypgksrLFDGRTGDPFEQPVTIGKAYILKLIHQVDDKIHARSSGPYALVTQQPLRGRSKQGGQRVG 986
                         1290      1300      1310      1320      1330      1340
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1402578118 1272 EMEVWALEAYGAAYTLQEMLTVKSDDVNGRTKMYKNIVSGNQQMDP-GTPESFNVIMKEIRSLGINID 1338
Cdd:CHL00001   987 EMEVWALEGFGVAYILQEMLTYKSDHIRARQEVLGAIITGGTIPKPeDAPESFRLLVRELRSLALELN 1054
rpoB CHL00207
RNA polymerase beta subunit; Provisional
23-1337 0e+00

RNA polymerase beta subunit; Provisional


Pssm-ID: 214397 [Multi-domain]  Cd Length: 1077  Bit Score: 1057.39  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118   23 NVPYLLTIQLDSFDKFIQrdpegqQGLEAAFRSVFPIVSNNGNTELQYVS--YRLGEPVFDVRECQIRGTTYAAPLRVKL 100
Cdd:CHL00207     6 ALPDFLEIQRTSFCWFLN------EGLNEELNIFSKIFDYTGNLELLLFGknYKLKYPKYNLLSAKSYDSNYSIQIYLPL 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  101 RLVSYDkdaapgtIKDIKEQEVYMGEIPLMTDNGTFVINGTERVIVSQLHRSPGVFFDSDKGKTHssgKVLYNARIIPYR 180
Cdd:CHL00207    80 KFINLK-------TNKIKFINYLIGNLPKMTQRGTFIINGLERVIVSQIIRSPGIYFKKEIKKNS---NKIYSATLIPNR 149
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  181 GSWLDFEFDPKDNLYARIDRRRKLPATIILRALNYTTEEILNlffdkvifqiednkllmdlvperlrgetatfdivanGK 260
Cdd:CHL00207   150 GSWIKFELDKNKEIWIRIDKNRKKPLIIFLKALGLTDQDIYS------------------------------------RL 193
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  261 TYvevgrritarhiralekdnvtqvevpteyivgkvaakdyvdletgevicpangeisleilaklsqagYKTIETLFTND 340
Cdd:CHL00207   194 TK-------------------------------------------------------------------SEFLKKLKPIL 206
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  341 LDYGPYIsdtlrvdpttdRLSALVEIYRMMRPGEPPTKEAAEGLFDNLFFSPDRYDLSAVGRMKFNRSLGIEETTGSGIL 420
Cdd:CHL00207   207 LNSNSYT-----------NEEILLEIYKNLSPIEPATVNDANQNLFSRFFDPKNYDLGKVGRYKINNKLNLNIPERVRNL 275
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  421 SKEDIVNVMRKLIDIRNGRGEVDDIDHLGNRRIRSVGEMAENQFRIGLVRVERAVKERLSLGDLEAVTPQDLINAKPISA 500
Cdd:CHL00207   276 TYEDILSIIDKLINLKINKGNFDDIDHLKNRRVRSVGELLQNQFRIGLKRLERILRNRMTICDIDSLSKFNLINPKPLIA 355
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  501 AVKEFFGSSQLSQFMDQNNPLSEVTHKRRISALGPGGLTRERAGFEVRDVHATHYGRVCPIETPEGPNIGLINSLAVYAR 580
Cdd:CHL00207   356 LIREFFGSSQLSQYMDQTNPLSELTHKRRISILGPGGLDKDRISFAVRDIHPSHYGRICPIETPEGPNCGLIGSLATNAR 435
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  581 TNDYGFLETPYRKVVNGQV--TEEIEYLSAIEEGKYIIAQANSNLDDELRFTDTFVTCRgEHGESGLYRPEEIHYMDVST 658
Cdd:CHL00207   436 INKFGFIETPFYKVINGKVkkFGNPIYLTADSEDLYRIAPNDINLNKNNYFKKNIIPVR-YKQEFKTVNPSKVDFIAISP 514
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  659 QQIVSVAAALIPFLEHDDANRALMGANMQRQAVPTLRADKPLVGTGMEKPVALDSGVAVVAKRGGTIQYVDASRIVVKVN 738
Cdd:CHL00207   515 IQVFSIAESLIPFLEHNDANRALMGSNMQRQAVPLLYPEKPIVGTGYEKQIALDSGMTIISLTEGIVVSVSAYKIIIQDD 594
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  739 EDETVageagidIYNLVKYTRSNQNTCINQIPCVKLGEPIERGEILADGPSTDLGELALGQNMRVAFMPWNGYNFEDSML 818
Cdd:CHL00207   595 NNRYI-------HYYLQKYQRSNQNTCINYRPIVWVGEKINIGQILADGSDIDNSELALGQNVLVAYMPWEGYNFEDAIL 667
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  819 VSERVVQEDRFTTIHIQELSCVARDTKLGSEEITADIPNVGEAALSKLDESGIVYIGAEVKGGDILVGKVTPKGETQLTP 898
Cdd:CHL00207   668 INKRLVYEDLFTSIHIEKYEIELRQTKLGSEEITRNIPNVSEYSLKNLDENGIISIGSKVLAGDILVGKITPKGESDQLP 747
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  899 EEKLLRAIFGEKASDVKDSSLRVPNSVSGTVIDVQVFTRDgvekdkraleieemqlkqakkdlveeleileaglfarvrn 978
Cdd:CHL00207   748 EGKLLRAIFGEKAKDVKDTSLRMPNGGYGRVIKVEIFSRS---------------------------------------- 787
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  979 vlisggmdaaqldkldrtkwleqtlsdeekqsqleqlaeqyeelrkdfehklevkrgkiiQGDDLAPGVLKVVKVYLAVK 1058
Cdd:CHL00207   788 ------------------------------------------------------------KGDELKFGYYLKIRVFIAQI 807
                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118 1059 RQIQPGDKMAGRHGNKGVISKINPVEDMPYDENGQPVDIVLNPLGVPSRMNIGQILETHLGLAakgiGDQINAMIKQkqd 1138
Cdd:CHL00207   808 RKIQVGDKLAGRHGNKGIISRILPRQDMPYLPDGTPPDIILNPLGVPSRMNVGQLFECLLGLA----GDNLNKRFKI--- 880
                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118 1139 veklrgyiqkaydlgggsqkVDLSTFTDEEVMRLAQNlrKGLPLATpvfdgaheeEIKGLLELGGLPTSGQITLYDGRTG 1218
Cdd:CHL00207   881 --------------------LPFDEMYGSEYSRILIN--NKLNQAS---------IKNNEYWLFNSYHPGKMVLRDGRTG 929
                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118 1219 EKFERPVTVGYMYMLKLNHLVDDKMHARSTGSYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGAAYTLQEMLTVKSDDV 1298
Cdd:CHL00207   930 YKFKNPVTVGIAYMLKLIHLVDDKIHARTTGPYSLVTQQPLGGKAQHGGQRFGEMEVWALEAFGAAYTLKELLTIKSDDM 1009
                         1290      1300      1310
                   ....*....|....*....|....*....|....*....
gi 1402578118 1299 NGRTKMYKNIVSGNQQMDPGTPESFNVIMKEIRSLGINI 1337
Cdd:CHL00207  1010 QGRNETLNAIVKGQPIPKPGTPESFKVLMRELQSLGLDI 1048
RNA_pol_B_RPB2 cd00653
RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. ...
27-1340 0e+00

RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase complex contains two related members of this family, in each case they are the two largest subunits.The clamp is a mobile structure that grips DNA during elongation.


Pssm-ID: 238353 [Multi-domain]  Cd Length: 866  Bit Score: 880.75  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118   27 LLTIQLDSFDKFIQrdpegqQGLEAAFRSVFPIVS--NNGNTELQYVSYRLGEPV---------FDVRECQIRGTTYAAP 95
Cdd:cd00653      1 LVKQQIDSFNYFLN------VGLQEIVKSIPPITDtdDDGRLKLKFGDIYLGKPKveeggvtrkLTPNECRLRDLTYSAP 74
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118   96 LRVKLRLVSYDKDaapgtikDIKEQEVYMGEIPLMTD------------------------NGTFVINGTERVIVSQLHR 151
Cdd:cd00653     75 LYVDIRLTVNDKG-------KIKEQEVFIGEIPIMLRsklcnlngltpeeliklgecpldpGGYFIINGTEKVIINQEQR 147
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  152 SPGVFFDSDkgkthSSGKVLYNARIIP----YRGSWLDFEFDPKDNlyaridrrrklpatiilralnytteeilnlffdk 227
Cdd:cd00653    148 SPNVIIVED-----SKGKRIYTKTSIPsyspYRGSWLEVKSDKKKD---------------------------------- 188
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  228 vifqiednkllmdlvperlrgetatfdivangktyvevgrRITARHiralekdnvtqvevpteyivgkvaakdyvdletg 307
Cdd:cd00653    189 ----------------------------------------RIYVRI---------------------------------- 194
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  308 evicpangeisleilaklsqagyktietlftndldygPYIsdtlrvdpttDRLSALVEIYRmmrpgepptkeaaeglfdn 387
Cdd:cd00653    195 -------------------------------------DLK----------RQEEALKYIGK------------------- 208
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  388 lffspdrydlsavgrmKFnrslgieettgsgilskEDIVNVMRKLIDIRNGRGEVDDIDHLGNRRIRSVGEMAENQFRIG 467
Cdd:cd00653    209 ----------------RF-----------------EDLIYMIRKLILLVLGKGKLDDIDHLGNKRVRLAGELLQNLFRSG 255
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  468 LVRVERAVKERLS--LGDLEAVTPQDLINAKPISAAVKEFFGSSQ------------LSQFMDQNNPLSEVTHKRRISAl 533
Cdd:cd00653    256 LKRLEREVKEKLQkqLSKKKDLTPQLLINSKPITSGIKEFLATGNwgskrflmqrsgLSQVLDRLNPLSELSHKRRISS- 334
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  534 gpGGLTRERAGFEVRDVHATHYGRVCPIETPEGPNIGLINSLAVYARTNdyGFLETPYRKVVngqvteeieylsaieegk 613
Cdd:cd00653    335 --LGLFRERKGFEVRDLHPSHWGRICPIETPEGENCGLVKNLALMARIS--GRIERPYRIVE------------------ 392
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  614 yiiaqansnlddelrftdtfvtcrgehgesglyrpEEIHYMDVSTQQIVSVAAALIPFLEHDDANRALMGANMQRQAVPT 693
Cdd:cd00653    393 -----------------------------------KEVTHIEISPSQILSVAASLIPFPEHNQSPRNLYQSNMQKQAVGT 437
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  694 ----------------LRADKPLVGTGMEKPVALdsgvavvakrggtiqyvdasrivvkvnedetvageagidiynlvky 757
Cdd:cd00653    438 palnqqyrmdtklyllLYPQKPLVGTGIEEYIAF---------------------------------------------- 471
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  758 trsnqntcinqipcvklgepiergeiladgpstdlGELALGQNMRVAFMPWNGYNFEDSMLVSERVVQEDRFTTIHIQEL 837
Cdd:cd00653    472 -----------------------------------GELPLGQNAIVAVMSYSGYNFEDAIIINKSSVDRGFFRSIHYKKY 516
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  838 SCVARDTKLGSEEIT-ADIPNVGEAALSKLDESGIVYIGAEVKGGDILVGKVTPKGETQLTPeekllraIFGEKASDVKD 916
Cdd:cd00653    517 EIELRKTKNGPEEITrGDIPNVSEEKLKNLDEDGIIRPGARVEPGDILVGKITPKGETESTP-------IFGEKARDVRD 589
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  917 SSLRVPNSVSGTVIDVQVFTRDgvekdkraleieemqlkqakkdlveeleileaglfarvrnvlisggmdaaqldkldrt 996
Cdd:cd00653    590 TSLKYPGGEKGIVDDVKIFSRE---------------------------------------------------------- 611
                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  997 kwleqtlsdeekqsqleqlaeqyeelrkdfehklevkrgkiiqgddLAPGVLKVVKVYLAVKRQIQPGDKMAGRHGNKGV 1076
Cdd:cd00653    612 ----------------------------------------------LNDGGNKLVKVYIRQKRKPQIGDKFASRHGQKGV 645
                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118 1077 ISKINPVEDMPYDENGQPVDIVLNPLGVPSRMNIGQILETHLGLAAKgigdqinamikqkqdveklrgyiqkaydlgggs 1156
Cdd:cd00653    646 ISKILPQEDMPFTEDGIPPDIILNPHGFPSRMTIGQLLESLLGKAGA--------------------------------- 692
                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118 1157 qkvdlstftdeevmrlaqnlRKGLPLATPVFDGAHEEEIKGLLELGGLPTSGQITLYDGRTGEKFERPVTVGYMYMLKLN 1236
Cdd:cd00653    693 --------------------LLGKFGDATPFDGAEEEDISELLGEAGLNYYGKEVLYDGRTGEPLEAPIFVGPVYYQRLK 752
                         1290      1300      1310      1320      1330      1340      1350      1360
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118 1237 HLVDDKMHARSTGSYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGAAYTLQEMLTVKSDDVNGRTKMYKNIV------- 1309
Cdd:cd00653    753 HMVDDKIHARSTGPYSLLTRQPLKGRSRGGGQRFGEMERDALIAHGAAYLLQERLTIKSDDVVARVCVKCGIIlsanlcr 832
                         1370      1380      1390
                   ....*....|....*....|....*....|....
gi 1402578118 1310 ---SGNQQMDPGTPESFNVIMKEIRSLGINIDLD 1340
Cdd:cd00653    833 lckKGTNISKVGIPYAFKLLFQELQSMNIDPRLK 866
RNA_pol_Rpb2_6 pfam00562
RNA polymerase Rpb2, domain 6; RNA polymerases catalyze the DNA dependent polymerization of ...
718-1264 2.49e-164

RNA polymerase Rpb2, domain 6; RNA polymerases catalyze the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). This domain represents the hybrid binding domain and the wall domain. The hybrid binding domain binds the nascent RNA strand / template DNA strand in the Pol II transcription elongation complex. This domain contains the important structural motifs, switch 3 and the flap loop and binds an active site metal ion. This domain is also involved in binding to Rpb1 and Rpb3. Many of the bacterial members contain large insertions within this domain, as region known as dispensable region 2 (DRII).


Pssm-ID: 459854 [Multi-domain]  Cd Length: 371  Bit Score: 495.90  E-value: 2.49e-164
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  718 VAKRGGTIQYVDASRIVVKVNEdetvaGEAGIDIYNLVKYTRSNQNT---CINQIPCVKLGEpIERGeiladgpstDLGE 794
Cdd:pfam00562    1 VASLIPFVDHNQSPRNTYQCAM-----GKQAMGIYTLNKFYRSDQNTyvlCYPQKPLVKTGA-VEAG---------GFGE 65
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  795 LALGQNMRVAFMPWNGYNFEDSMLVSERVVQEDRFTTIHIQElsCVARDTKLG-SEEITADIPNVGEAALSKLDESGIVY 873
Cdd:pfam00562   66 LPLGQNAIVAVMSYTGYNQEDAIIINKSSVDRGFFTSIHIKE--IEARKTKLGpIEEITRDIPNVSEEALKKLDEDGIVR 143
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  874 IGAEVKGGDILVGKVtpkGETQLTpeeKLLRAIFGEKASDVKDSSLRVPNSVSGTVIDVQVFtrdgvekdkraleieemq 953
Cdd:pfam00562  144 VGAEVKPGDILVGKV---GPTELT---KLLRAIFGEKARDVKDTSLKVPPGEEGVVDDVIVF------------------ 199
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  954 lkqakkdlveeleileaglfarvrnvlisggmdaaqldkldrtkwleqtlsdeekqsqleqlaeqyeelrkdfehklevk 1033
Cdd:pfam00562      --------------------------------------------------------------------------------
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118 1034 rgkiiqgdDLAPGVLKVVKVYLAVKRQIQPGDKMAGRHGNKGVISKINPVEDMPYDENGQPVDIVLNPLGVPSRMNIGQI 1113
Cdd:pfam00562  200 --------ELPPGGIKMVKVYIRQKRKPEVGDKFASRHGQKGVVSRILPQEDMPFTEDGIPPDIILNPHGVPSRMTIGQL 271
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118 1114 LETHLGLAAKGigdqinamikqkqdveklrgyiqkaydlgggsqkvdlstftdeevmrlaqnlrKGLPLATPVFDGAHE- 1192
Cdd:pfam00562  272 LETHLGKAAAL-----------------------------------------------------LGVFVDATPFDGASTe 298
                          490       500       510       520       530       540       550
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1402578118 1193 -EEIKGLLELGGLPTSGQITLYDGRTGEKFERPVTVGYMYMLKLNHLVDDKMHARSTGSYSLVTQQPLGGKAQ 1264
Cdd:pfam00562  299 vEDIGELLEKAGYNYYGKEVLYDGRTGEPFEAPIFVGPIYYQKLKHMVDDKIHARSTGPYSLLTRQPLGGRAR 371
RNA_pol_Rpb2_1 pfam04563
RNA polymerase beta subunit; RNA polymerases catalyze the DNA dependent polymerization of RNA. ...
26-500 3.40e-97

RNA polymerase beta subunit; RNA polymerases catalyze the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). This domain forms one of the two distinctive lobes of the Rpb2 structure. This domain is also known as the protrusion domain. The other lobe (pfam04561) is nested within this domain.


Pssm-ID: 367994 [Multi-domain]  Cd Length: 396  Bit Score: 317.40  E-value: 3.40e-97
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118   26 YLLTIQLDSFDKFIQRDPEGQQGLEAAFRSVFPIVSNNGNT---ELQYVSYRLGEPVFDVR----------ECQIRGTTY 92
Cdd:pfam04563    1 GLVRQQLDSFNEFVDNDLQKIIDENALIESEFEIQHPGENGdklSLKFGQIRLGKPMFDETdgstreiypqECRLRNLTY 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118   93 AAPLRVKLRLVSYDKdaapgtiKDIKEQEVYMGEIPLMTDN------------------------GTFVINGTERVIVSQ 148
Cdd:pfam04563   81 SAPLYVDLELSVYNG-------EDIKPIEVFIGRLPIMLRSnacilsgateselvklgecpldpgGYFIINGSEKVIVAQ 153
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  149 LHRS---PGVFFDSDKGKTHSSGKVLYNARI--IPYRGSWLDF-EFDPKDNLYARIDRRRK-LPATIILRALNYTTEEIL 221
Cdd:pfam04563  154 EHRSrnhPIVFKKADPKKRGSVASVRSSAEIsvRPDSTSWVNVlEYLSNGTIYFKFPYIKKeIPIVIILRALGFTSDREI 233
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  222 nlfFDKVIFQIEDNKLLMDLVPErlrgetatfdivangktyVEVGRRItarhiralekdNVTQVEVPTEYIVGKVAAkdy 301
Cdd:pfam04563  234 ---FELICYDVNDQQLQEELLPS------------------LEEGFKI-----------RIQTQEQALDYIGGRGRA--- 278
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  302 vdletgevicpangeisleilaklsqagyktietlftndldygpyisdtlrvdpttdrlsalveIYRMMRPGEPPTKEAA 381
Cdd:pfam04563  279 ----------------------------------------------------------------IFRMGRPREPRIKYAE 294
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  382 EGLFDNLFFSPDRYDLSAVGRMKFnrslgieettgsgilskedIVNVMRKLIDIRNGRGEVDDIDHLGNRRIRSVGEMAE 461
Cdd:pfam04563  295 EILQKEVLPHLGTYELDETKKAYF-------------------IGYMIRRLLLLALGRREVDDRDHLGNKRLRLAGPLLA 355
                          490       500       510       520
                   ....*....|....*....|....*....|....*....|.
gi 1402578118  462 NQFRIGLVRVERAVKERL--SLGDLEAVTPQDLINAKPISA 500
Cdd:pfam04563  356 SLFRVLFKKLVRDVRERLqkVLGSPDDLMLQLLVNAKPITS 396
PRK08565 PRK08565
DNA-directed RNA polymerase subunit B; Provisional
31-1305 2.76e-89

DNA-directed RNA polymerase subunit B; Provisional


Pssm-ID: 236291 [Multi-domain]  Cd Length: 1103  Bit Score: 314.59  E-value: 2.76e-89
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118   31 QLDSFDKFIQRdpeGQQGLEAAFRSVFPIVsnnGNTELQYVSYRLGEPVFDV----------RECQIRGTTYAAPLRVKL 100
Cdd:PRK08565    18 HLDSYNDFIER---GLQEIVDEFGEIKTEI---PGLKIVLGKIRVGEPEIKEadgserpitpMEARLRNLTYAAPLYLTM 91
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  101 RLVsydkdaAPGTIKdiKEQEVYMGEIPLMT----DN--------------------GTFVINGTERVIVSQLHRSPG-V 155
Cdd:PRK08565    92 IPV------ENGIEY--EPEEVKIGDLPIMVkskiCPlsglspdelieigedpkdpgGYFIINGSERVIVSQEDLAPNrV 163
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  156 FFDSDKgkthSSGKVLYNARIIPYRG---SWLDFEFDPKDNLYARIDR-RRKLPATIILRALnytteeilnlffdkvifq 231
Cdd:PRK08565   164 LVDKGE----AGSSITHTAKVISSRAgyrAQVTVERRKDGTIYVSFPAvPGKIPFVILMRAL------------------ 221
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  232 iednkllmdlvperlrgetatfdivangktyvevgrritarhirALEKDnvtqvevptEYIVGKVAAKDyvdletgevic 311
Cdd:PRK08565   222 --------------------------------------------GLETD---------RDIVYAVSLDP----------- 237
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  312 pangEISLEILAKLSQAGyktietlftndldygpyisdtlRVDPTTDrlSALVEIYRMMRPGEPPTK--EAAEGLFDNLF 389
Cdd:PRK08565   238 ----EIQQELLPSLEQAS----------------------SIAATVE--DALDYIGKRVAIGQPREYriERAEQILDKYL 289
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  390 fspdrydLSAVGRMKFNRslgieettgsgiLSKEDIVNVM-RKLIDIRNGRGEVDDIDHLGNRRIRSVGEMAENQFRIGL 468
Cdd:PRK08565   290 -------LPHLGTSPEDR------------IKKAYFLGQMaSKLLELYLGRREPDDKDHYANKRLRLAGDLLAELFRVAF 350
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  469 VRVERAVKERL----SLG---DLEAVTPQDLINAKPISA-AVKEFFGS-SQLSQFMDQNNPLSEVTHKRRIsaLGPggLT 539
Cdd:PRK08565   351 KQLVKDLKYQLeksyARGrklDLRAIVRPDIITERIRHAlATGNWVGGrTGVSQLLDRTNYLSTLSHLRRV--VSP--LS 426
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  540 RERAGFEVRDVHATHYGRVCPIETPEGPNIGLINSLAVYAR----TNDYGFLETPYRK-VVNGQVTEEIEYLSA------ 608
Cdd:PRK08565   427 RGQPHFEARDLHGTQWGRICPFETPEGPNCGLVKNLALMAQisvgVDEEEVEEILYELgVVPVEEAREEEYISWsrvyln 506
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  609 ------IEEGKYIIA-------------QANSNLDDELRFTDTFVTCRG----------EHGESGLYR------------ 647
Cdd:PRK08565   507 grligyHPDGEELAEkirelrrsgkisdEVNVAYIETGEINEVYVNCDSgrvrrplivvENGKPKLTRehveklkkgelt 586
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  648 --------------------------PEEI---H-YMDVSTQQIVSVAAALIPFLEHDDANRALMGANMQRQA--VPT-- 693
Cdd:PRK08565   587 fddlvkmgvieyldaeeeenayvaldPEDLtpeHtHLEIWPPAILGITASIIPYPEHNQSPRNTYQAAMAKQSlgLYAan 666
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  694 --LRAD----------KPLVGT-GMEkpvaldsgvavvakrggtiqyvdasrivvkvnedetvageagidiynLVKYTrs 760
Cdd:PRK08565   667 frIRTDtrghllhypqRPLVQTrALE-----------------------------------------------IIGYN-- 697
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  761 nqntcinqipcvklgepiergeilaDGPStdlgelalGQNMRVAFMPWNGYNFEDSMLVSERVVQEDRFTTIHIQELSCV 840
Cdd:PRK08565   698 -------------------------DRPA--------GQNAVVAVLSYTGYNIEDAIIMNKASIERGLARSTFFRTYETE 744
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  841 ARDTKLGSE-EITADIPNV----GEAALSKLDESGIVYIGAEVKGGDILVGKVTPKgetQLTPEEKLLRAIFGEKasdvK 915
Cdd:PRK08565   745 ERKYPGGQEdKIEIPEPNVrgyrGEEYYRKLDEDGIVSPEVEVKGGDVLIGKTSPP---RFLEELEELSLGLQER----R 817
                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  916 DSSlrvpnsvsgtvidvqVFTRDGvekdkraleieemqlkqakkdlveeleilEAGLfarVRNVLISggmdaaqlDKLDR 995
Cdd:PRK08565   818 DTS---------------VTVRHG-----------------------------EKGI---VDTVLIT--------ESPEG 842
                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  996 TKwleqtlsdeekqsqleqlaeqyeelrkdfehklevkrgkiiqgddlapgvlkVVKVYLAVKRQIQPGDKMAGRHGNKG 1075
Cdd:PRK08565   843 NK----------------------------------------------------LVKVRVRDLRIPELGDKFASRHGQKG 870
                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118 1076 VISKINPVEDMPYDENGQPVDIVLNPLGVPSRMNIGQILEThlgLAAKgigdqinamikqkqdVEKLRGyiqkaydlggg 1155
Cdd:PRK08565   871 VIGMLVPQEDMPFTEDGIVPDLIINPHAIPSRMTVGQLLES---IAGK---------------VAALEG----------- 921
                         1290      1300      1310      1320      1330      1340      1350      1360
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118 1156 sQKVDlstftdeevmrlaqnlrkglplATPvFDGAHEEEIKGLLELGGLPTSGQITLYDGRTGEKFERPVTVGYMYMLKL 1235
Cdd:PRK08565   922 -RFVD----------------------ATP-FYGEPEEELRKELLKLGYKPDGTEVMYDGRTGEKIKAPIFIGVVYYQKL 977
                         1370      1380      1390      1400      1410      1420      1430
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118 1236 NHLVDDKMHARSTGSYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGAAYTLQEMLTVKSDdvngRTKMY 1305
Cdd:PRK08565   978 HHMVADKIHARARGPVQILTRQPTEGRAREGGLRFGEMERDCLIGHGAAMLLKERLLDSSD----KTTIY 1043
rpoB_arch TIGR03670
DNA-directed RNA polymerase subunit B; This model represents the archaeal version of ...
603-1305 1.06e-58

DNA-directed RNA polymerase subunit B; This model represents the archaeal version of DNA-directed RNA polymerase subunit B (rpoB) and is observed in all archaeal genomes.


Pssm-ID: 274713 [Multi-domain]  Cd Length: 599  Bit Score: 214.12  E-value: 1.06e-58
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  603 IEYLSAIEEGKYIIAQANSNLddelrftdtfvtcrgehgesglyRPEEIHyMDVSTQQIVSVAAALIPFLEHDDANRALM 682
Cdd:TIGR03670   92 IEYLDAEEEENAYIALDPEEL-----------------------TPEHTH-LEIDPSAILGIIASTIPYPEHNQSPRNTM 147
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  683 GANMQRQAVPTLRADKPLvgtgmekpvALDSgvavvakRGGTIQYVdasrivvkvnedetvageagidiynlvkytrsnq 762
Cdd:TIGR03670  148 GAAMAKQSLGLYAANYRI---------RLDT-------RGHLLHYP---------------------------------- 177
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  763 ntcinQIPCVKlgepiERGEILadgpsTDLGELALGQNMRVAFMPWNGYNFEDSMLVSERVVQEDRFTTIHIQELSCVAR 842
Cdd:TIGR03670  178 -----QKPLVK-----TRVLEL-----IGYDDRPAGQNFVVAVMSYEGYNIEDALIMNKASIERGLARSTFFRTYEAEER 242
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  843 DTKLGSE-EITADIPNV----GEAALSKLDESGIVYIGAEVKGGDILVGKVTPkgetqltP---EEkllRAIFGEKASDV 914
Cdd:TIGR03670  243 RYPGGQEdRFEIPEPDVrgyrGEEAYKHLDEDGIVYPEVEVKGGDVLIGKTSP-------PrflEE---LREFGLVTERR 312
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  915 KDSSLRVPNSVSGtVIDvqvftrdgvekdkraleieemqlkqakkdlveeleileaglfarvrNVLISGGMDAAqldkld 994
Cdd:TIGR03670  313 RDTSVTVRHGEKG-IVD----------------------------------------------KVIITETEEGN------ 339
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  995 rtkwleqtlsdeekqsqleqlaeqyeelrkdfehklevkrgkiiqgddlapgvlKVVKVYLAVKRQIQPGDKMAGRHGNK 1074
Cdd:TIGR03670  340 ------------------------------------------------------KLVKVRVRDLRIPELGDKFASRHGQK 365
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118 1075 GVISKINPVEDMPYDENGQPVDIVLNPLGVPSRMNIGQILEThlgLAAKgigdqinamikqkqdVEKLRGyiqkaydlgg 1154
Cdd:TIGR03670  366 GVIGMIVPQEDMPFTEDGIVPDLIINPHAIPSRMTVGQLLEM---IAGK---------------VAALEG---------- 417
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118 1155 gsQKVDlstftdeevmrlaqnlrkglplATPvFDGAHEEEIKGLLELGGLPTSGQITLYDGRTGEKFERPVTVGYMYMLK 1234
Cdd:TIGR03670  418 --RRVD----------------------GTP-FEGEPEEELRKELLKLGFKPDGKEVMYDGITGEKLEAEIFIGVIYYQK 472
                          650       660       670       680       690       700       710
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1402578118 1235 LNHLVDDKMHARSTGSYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGAAYTLQEMLTVKSDdvngRTKMY 1305
Cdd:TIGR03670  473 LHHMVADKIHARSRGPVQVLTRQPTEGRAREGGLRFGEMERDVLIGHGAAMLLKERLLDESD----KYVVY 539
PRK07225 PRK07225
DNA-directed RNA polymerase subunit B'; Validated
593-1298 3.77e-50

DNA-directed RNA polymerase subunit B'; Validated


Pssm-ID: 235972 [Multi-domain]  Cd Length: 605  Bit Score: 188.63  E-value: 3.77e-50
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  593 KVVNGQVTEE-------IEYLSAIEEGKYIIAQANSNLddelrftdtfvtcrgehgesglyRPEEIHyMDVSTQQIVSVA 665
Cdd:PRK07225    81 KLKNGELTFDdlvkqgvIEYLDAEEEENAYIAVYEEDL-----------------------TEEHTH-LEIDPSLILGIG 136
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  666 AALIPFLEHDDANRALMGANMQRQAVPTLRADKPLvgtgmeKPvalDSgvavvakRGGTIQYVdasrivvkvnedetvag 745
Cdd:PRK07225   137 AGMIPYPEHNASPRITMGAGMIKQSLGLPAANYKL------RP---DT-------RGHLLHYP----------------- 183
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  746 eagidiynlvkytrsnqntcinQIPCVKLgEPIErgeiladgpSTDLGELALGQNMRVAFMPWNGYNFEDSMLVSERVV- 824
Cdd:PRK07225   184 ----------------------QVPLVKT-QTQE---------IIGFDERPAGQNFVVAVMSYEGYNIEDALIMNKASIe 231
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  825 ----------------------QEDRFTtihiqelscvardtkLGSEEITAdipNVGEAALSKLDESGIVYIGAEVKGGD 882
Cdd:PRK07225   232 rglgrshffrtyegeerrypggQEDRFE---------------IPDKDVRG---YRGEEAYRHLDEDGLVNPETEVKEGD 293
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  883 ILVGKVTPkgetqltP---EEKllrAIFGEKASDVKDSSLRVPNSVSGTVidvqvftrdgvekdkraleieemqlkqakk 959
Cdd:PRK07225   294 VLIGKTSP-------PrflEEP---DDFGISPEKRRETSVTMRSGEEGIV------------------------------ 333
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  960 DLVeeleileaglfarvrnvlisggmdaaqldkldrtkwleqTLSDEEKQSQLeqlaeqyeelrkdfehklevkrgkiiq 1039
Cdd:PRK07225   334 DTV---------------------------------------ILTETEEGSRL--------------------------- 347
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118 1040 gddlapgvlkvVKVYLAVKRQIQPGDKMAGRHGNKGVISKINPVEDMPYDENGQPVDIVLNPLGVPSRMNIGQILEthlg 1119
Cdd:PRK07225   348 -----------VKVRVRDLRIPELGDKFASRHGQKGVIGLIVPQEDMPFTESGVVPDLIINPHAIPSRMTVGHVLE---- 412
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118 1120 laakgigdqinaMIKQKqdVEKLRGyiqkaydlgggsQKVDlstftdeevmrlaqnlrkglplATPvFDGAHEEEIKGLL 1199
Cdd:PRK07225   413 ------------MIGGK--VGSLEG------------RRVD----------------------GTA-FSGEDEEDLREAL 443
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118 1200 ELGGLPTSGQITLYDGRTGEKFERPVTVGYMYMLKLNHLVDDKMHARSTGSYSLVTQQPLGGKAQFGGQRFGEMEVWALE 1279
Cdd:PRK07225   444 EKLGFEHTGKEVMYDGITGEKIEAEIFVGVIYYQKLHHMVANKLHARSRGPVQVLTRQPTEGRAREGGLRFGEMERDVLI 523
                          730
                   ....*....|....*....
gi 1402578118 1280 AYGAAYTLQEMLTVKSDDV 1298
Cdd:PRK07225   524 GHGAAMLLKERLLDESDKV 542
RNA_pol_Rpb2_3 pfam04565
RNA polymerase Rpb2, domain 3; RNA polymerases catalyze the DNA dependent polymerization of ...
513-580 2.63e-35

RNA polymerase Rpb2, domain 3; RNA polymerases catalyze the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Domain 3, s also known as the fork domain and is proximal to catalytic site.


Pssm-ID: 428011 [Multi-domain]  Cd Length: 67  Bit Score: 128.41  E-value: 2.63e-35
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1402578118  513 QFMDQNNPLSEVTHKRRISAlGPGGLTRERAGFEVRDVHATHYGRVCPIETPEGPNIGLINSLAVYAR 580
Cdd:pfam04565    1 QVLDRTNYLSTLSHLRRVNS-PRGGLFREMKTTEVRDLHPSHWGRICPVETPEGPNCGLVKHLALYAR 67
RNA_pol_Rpb2_7 pfam04560
RNA polymerase Rpb2, domain 7; RNA polymerases catalyze the DNA dependent polymerization of ...
1266-1342 1.07e-30

RNA polymerase Rpb2, domain 7; RNA polymerases catalyze the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Rpb2 is the second largest subunit of the RNA polymerase. This domain comprised of the structural domains anchor and clamp. The clamp region (C-terminal) contains a zinc-binding motif. The clamp region is named due to its interaction with the clamp domain found in Rpb1. The domain also contains a region termed "switch 4". The switches within the polymerase are thought to signal different stages of transcription.


Pssm-ID: 461355 [Multi-domain]  Cd Length: 87  Bit Score: 116.15  E-value: 1.07e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118 1266 GGQRFGEMEVWALEAYGAAYTLQEMLTVKSD----DVNGRTKMYKN-----IVSGNQQMDPGT-PESFNVIMKEIRSLGI 1335
Cdd:pfam04560    1 GGLRFGEMERWALIAYGAAHTLQERLTIKSDayevDVCGRCGLYAAynkcpICKGETDISPGYiPESFKLLFQELQSLGI 80

                   ....*..
gi 1402578118 1336 NIDLDEE 1342
Cdd:pfam04560   81 DPRLLLE 87
RNA_pol_Rpb2_45 pfam10385
RNA polymerase beta subunit external 1 domain; RNA polymerases catalyze the DNA-dependent ...
591-657 1.11e-28

RNA polymerase beta subunit external 1 domain; RNA polymerases catalyze the DNA-dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared with three in eukaryotes (not including mitochondrial or chloroplast polymerases). This domain in prokaryotes spans the gap between domains 4 and 5 of the yeast protein. It is also known as the external 1 region of the polymerase and is bound in association with the external 2 region.


Pssm-ID: 463067 [Multi-domain]  Cd Length: 66  Bit Score: 109.76  E-value: 1.11e-28
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1402578118  591 YRKVVNGQVTEEIEYLSAIEEGKYIIAQANSNLDDELRFTDTFVTCRgEHGESGLYRPEEIHYMDVS 657
Cdd:pfam10385    1 YRKVEDGKVTDEIVYLTADEEDGYVIAQANAPLDEDGRFVDERVSAR-YRGEFPLVPPEEVDYMDVS 66
PRK09606 PRK09606
DNA-directed RNA polymerase subunit B''; Validated
31-579 1.02e-26

DNA-directed RNA polymerase subunit B''; Validated


Pssm-ID: 236587 [Multi-domain]  Cd Length: 494  Bit Score: 115.82  E-value: 1.02e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118   31 QLDSFDKFIQRdpegqqGLEAAFRSVFPIVSNNGNTE-LQYVSYRLGEPVfdVRECQ------------IRGTTYAAPLR 97
Cdd:PRK09606    22 HIDSYNDFVDN------GLQKIIDEQGPIETEIEDGVyVELGKIRVGKPV--VKEADgsereiypmearLRNLTYSAPLY 93
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118   98 VKLRLVSYDKDAAPgtikdikeQEVYMGEIPLM-----------TDN-------------GTFVINGTERVIVSQLHRSP 153
Cdd:PRK09606    94 LEMSPVEGGEEEEP--------EEVYIGELPVMvgskicnlyglSEEelievgedpldpgGYFIVNGSERVLMTLEDLAP 165
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  154 GVF---FDSDKGKTHSSGKVL-----YNARIIpyrgswldFEFDPKDNLYARIDR-RRKLPATIILRALNYTTEEilnlf 224
Cdd:PRK09606   166 NKIlveKDERYGDRIEVAKVFsqrrgYRALVT--------VERNRDGLLEVSFPSvPGSIPFVILMRALGLETDE----- 232
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  225 fdKVIFQIEDNKllmdlvperlrgETATFdIVANgktyvevgrritarhiraLEKDNVTQVEVPTEYIVGKVAAKdyvdl 304
Cdd:PRK09606   233 --EIVEAVSDDP------------EIVKF-MLEN------------------LEEAEVDTQEEALEYIGKRVAPG----- 274
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  305 ETGEvicpangeisleilaklsqagyktietlftndldygpyisdtlrvdpttdrlsalveiYRMMRpgepptkeaAEGL 384
Cdd:PRK09606   275 QTKE----------------------------------------------------------YRIKR---------AEYV 287
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  385 FDNLFFSpdrydlsavgrmkfnrSLGIEEttgSGILSKEDIVNVM-RKLIDIRNGRGEVDDIDHLGNRRIRSVGEMAENQ 463
Cdd:PRK09606   288 IDRYLLP----------------HLGVEP---EVRRAKAHYLGRMaEACFELALGRREEDDKDHYANKRLKLAGDLMEDL 348
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  464 FRIGLVRVERAVK---ER-------LSLGdlEAVTPqDLINAKPISA-AVKEFFGS-SQLSQFMDQNNPLSEVTHKRRIS 531
Cdd:PRK09606   349 FRVAFNRLARDVKyqlERanmrnreLSIK--TAVRS-DVLTERLEHAmATGNWVGGrTGVSQLLDRTDYMATLSHLRRVV 425
                          570       580       590       600
                   ....*....|....*....|....*....|....*....|....*...
gi 1402578118  532 AlgpgGLTRERAGFEVRDVHATHYGRVCPIETPEGPNIGLINSLAVYA 579
Cdd:PRK09606   426 S----PLSRSQPHFEARDLHPTQWGRICPSETPEGPNCGLVKNFAQMV 469
RNA_pol_Rpb2_2 pfam04561
RNA polymerase Rpb2, domain 2; RNA polymerases catalyze the DNA dependent polymerization of ...
151-454 2.85e-12

RNA polymerase Rpb2, domain 2; RNA polymerases catalyze the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Rpb2 is the second largest subunit of the RNA polymerase. This domain forms one of the two distinctive lobes of the Rpb2 structure. This domain is also known as the lobe domain. DNA has been demonstrated to bind to the concave surface of the lobe domain, and plays a role in maintaining the transcription bubble. Many of the bacterial members contain large insertions within this domain, as region known as dispensable region 1 (DRI).


Pssm-ID: 398318 [Multi-domain]  Cd Length: 185  Bit Score: 66.60  E-value: 2.85e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  151 RSPGVFFDSDKGKTHSSGKvlYNARIIPYRGSWLDFEFDPKDNLYARIDRRRKLPATIILRALNYTT-EEILNLffdkVI 229
Cdd:pfam04561    1 RSNGIYVEKELDKNGIIAT--YTSSLISNRGSWLKLEIDGKTLIWSRPSKKRKIPIVIFLKALGLVSdREILDR----LC 74
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  230 FQIEDNKLLMDLVPErlrgetatfdivangktyvevgrritarhiralekdnvtqvevpteyivgkvaakdyvdLETGEV 309
Cdd:pfam04561   75 YDFNDPQMLELLKPE-----------------------------------------------------------LEEAEN 95
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402578118  310 ICpangeisleilaklsqagykTIETlftndldygpyisdtlrvdpttdrlsALVEIYRM--MRPGEPPTKEAAEGLFDN 387
Cdd:pfam04561   96 IY--------------------TQEE--------------------------ALDYIGKGfaLRRGEEPRLQRAREILYS 129
                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1402578118  388 LFfspdrydlsavGRMKFNRSLGIEETTGSGILSKEDIVNVMRKLIDIRNGRGEVDDIDHLGNRRIR 454
Cdd:pfam04561  130 RD-----------PKYNLNKHLGLNEPFENERLKAQDILYMIDRLLNLKLGRRKPDDIDHLGNKRVR 185
PRK00566 PRK00566
DNA-directed RNA polymerase subunit beta'; Provisional
290-334 4.22e-05

DNA-directed RNA polymerase subunit beta'; Provisional


Pssm-ID: 234794 [Multi-domain]  Cd Length: 1156  Bit Score: 48.14  E-value: 4.22e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 1402578118  290 EYIVGKVAAKDYVDLETGEVICPANGEISLEILAKLSQAGYKTIE 334
Cdd:PRK00566   804 ERILGRVLAEDVVDPETGEVIVPAGTLIDEEIADKIEEAGIEEVK 848
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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