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Conserved domains on  [gi|1402977453|ref|WP_110823002|]
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MULTISPECIES: MarR family winged helix-turn-helix transcriptional regulator [Paenibacillus]

Protein Classification

MarR family winged helix-turn-helix transcriptional regulator( domain architecture ID 11448790)

MarR family winged helix-turn-helix (wHTH) transcriptional regulator similar to Bacillus thuringiensis DNA-binding transcriptional repressor TubR, a DNA-binding protein that is part of the type III plasmid partition system used to ensure correct segregation of the pBtoxis plasmid

Gene Ontology:  GO:0006355|GO:0003700
PubMed:  10498949|28670937
SCOP:  4000246

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
7-134 2.73e-27

DNA-binding transcriptional regulator, MarR family [Transcription];


:

Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 98.50  E-value: 2.73e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402977453   7 QENLLILLKNISNQLKPKFERC---TGISSSRYVLLYHLYIHEEVTQSHLQKAIHIDSAAITRHLKQLEADGLVSRRRNP 83
Cdd:COG1846     9 EERLGLLLRRLARALRRALDRAlaeLGLTPAQFRVLAALAEAGGLTQSELAERLGLTKSTVSRLLDRLEEKGLVEREPDP 88

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1402977453  84 IDQRETFVRLTEQGLTHIANFKQDRNQFVHQMLLDFSEEEVAMMTDMLARM 134
Cdd:COG1846    89 EDRRAVLVRLTEKGRALLEEARPALEALLAELLAGLSEEELEALLRLLRRL 139
 
Name Accession Description Interval E-value
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
7-134 2.73e-27

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 98.50  E-value: 2.73e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402977453   7 QENLLILLKNISNQLKPKFERC---TGISSSRYVLLYHLYIHEEVTQSHLQKAIHIDSAAITRHLKQLEADGLVSRRRNP 83
Cdd:COG1846     9 EERLGLLLRRLARALRRALDRAlaeLGLTPAQFRVLAALAEAGGLTQSELAERLGLTKSTVSRLLDRLEEKGLVEREPDP 88

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1402977453  84 IDQRETFVRLTEQGLTHIANFKQDRNQFVHQMLLDFSEEEVAMMTDMLARM 134
Cdd:COG1846    89 EDRRAVLVRLTEKGRALLEEARPALEALLAELLAGLSEEELEALLRLLRRL 139
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
24-124 7.64e-22

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 83.41  E-value: 7.64e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402977453   24 KFERCTGISSSRYVLLYHLYIHEEVTQSHLQKAIHIDSAAITRHLKQLEADGLVSRRRNPIDQRETFVRLTEQGLTHIAN 103
Cdd:smart00347   1 EELKPLGLTPTQFLVLRILYEEGPLSVSELAKRLGVSPSTVTRVLDRLEKKGLVRREPSPEDRRSVLVSLTEEGRELIEQ 80

                           90       100
                   ....*....|....*....|.
gi 1402977453  104 FKQDRNQFVHQMLLDFSEEEV 124
Cdd:smart00347  81 LLEARSETLAELLAGLTAEEQ 101
MarR pfam01047
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 31-89 2.92e-12

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 426012 [Multi-domain]  Cd Length: 59  Bit Score: 57.56  E-value: 2.92e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1402977453  31 ISSSRYVLLYHLYIHEEVTQSHLQKAIHIDSAAITRHLKQLEADGLVSRRRNPIDQRET 89
Cdd:pfam01047   1 LTLTQFHILRILYEHGPLTVSELAEKLGVSKSTVTRVLDRLEKKGLIERSRSPEDRREV 59
PRK03573 PRK03573
transcriptional regulator SlyA; Provisional
 17-141 4.16e-09

transcriptional regulator SlyA; Provisional


Pssm-ID: 179596  Cd Length: 144  Bit Score: 51.54  E-value: 4.16e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402977453  17 ISNQLKPkfercTGISSSRYVLLYHLY-IHEEVTQSHLQKAIHIDSAAITRHLKQLEADGLVSRRRNPIDQRETFVRLTE 95
Cdd:PRK03573   20 IDHRLKP-----LELTQTHWVTLHNIHqLPPEQSQIQLAKAIGIEQPSLVRTLDQLEEKGLISRQTCASDRRAKRIKLTE 94

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1402977453  96 QGLTHIANFKQDRNQFVHQMLLDFSEEEVAMMTDMLARMQFNMKDM 141
Cdd:PRK03573   95 KAEPLISEVEAVINKTRAEILHGISAEEIEQLITLIAKLEKNIIEL 140
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 32-95 8.87e-07

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 43.83  E-value: 8.87e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1402977453  32 SSSRYVLLYHLYiHEEVTQSHLQKAIHIDSAAITRHLKQLEADGLVSRRRnpiDQRETFVRLTE 95
Cdd:cd00090     6 DPTRLRILRLLL-EGPLTVSELAERLGLSQSTVSRHLKKLEEAGLVESRR---EGRRVYYSLTD 65
Staph_reg_Sar TIGR01889
staphylococcal accessory regulator family; This model represents a family of transcriptional ...
 8-111 8.06e-05

staphylococcal accessory regulator family; This model represents a family of transcriptional regulatory proteins in Staphylococcus aureus and Staphylococcus epidermidis. Some members contain two tandem copies of this region. This family is related to the MarR transcriptional regulator family described by pfam01047. [Regulatory functions, DNA interactions]


Pssm-ID: 130944  Cd Length: 109  Bit Score: 39.55  E-value: 8.06e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402977453   8 ENLLILLKNISNQLKPKFerctGISSSRYVLLYHLYIHE----EVTQSHLQKAIHIDSAAITRHLKQLEADGLVSRRRNP 83
Cdd:TIGR01889   4 LSLYLYIKSLKRYLKKEF----NLSLEELLILYYLGKLEnnegKLTLKEIIKEILIKQSALVKIIKKLSKKGYLSKERSE 79

                          90       100
                  ....*....|....*....|....*...
gi 1402977453  84 IDQRETFVRLTEQGLTHIANFKQDRNQF 111
Cdd:TIGR01889  80 DDERKVIISINKEQRSKIESLISEIEQI 107
HTH_metalloreg NF033788
metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense ...
 35-81 8.84e-04

metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense toxic heavy metals such as arsenic or cadmium, and are released from DNA so that resistance factors will be expressed, include ArsR, SmtB, ZiaR, CadC, CadX, KmtR, etc. However, some members of this family, including the sporulation delaying system autorepressor SdpR and its family (see NF033789), may lack metal-binding cites and instead regulate other cellular processes.


Pssm-ID: 411368 [Multi-domain]  Cd Length: 76  Bit Score: 35.90  E-value: 8.84e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1402977453  35 RYVLLYHLyIHEEVTQSHLQKAIHIDSAAITRHLKQLEADGLVSRRR 81
Cdd:NF033788   13 RLRILELL-AEGELCVCELAEALGLSQSAVSQHLKVLRDAGLVTSRR 58
 
Name Accession Description Interval E-value
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
7-134 2.73e-27

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 98.50  E-value: 2.73e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402977453   7 QENLLILLKNISNQLKPKFERC---TGISSSRYVLLYHLYIHEEVTQSHLQKAIHIDSAAITRHLKQLEADGLVSRRRNP 83
Cdd:COG1846     9 EERLGLLLRRLARALRRALDRAlaeLGLTPAQFRVLAALAEAGGLTQSELAERLGLTKSTVSRLLDRLEEKGLVEREPDP 88

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1402977453  84 IDQRETFVRLTEQGLTHIANFKQDRNQFVHQMLLDFSEEEVAMMTDMLARM 134
Cdd:COG1846    89 EDRRAVLVRLTEKGRALLEEARPALEALLAELLAGLSEEELEALLRLLRRL 139
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
24-124 7.64e-22

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 83.41  E-value: 7.64e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402977453   24 KFERCTGISSSRYVLLYHLYIHEEVTQSHLQKAIHIDSAAITRHLKQLEADGLVSRRRNPIDQRETFVRLTEQGLTHIAN 103
Cdd:smart00347   1 EELKPLGLTPTQFLVLRILYEEGPLSVSELAKRLGVSPSTVTRVLDRLEKKGLVRREPSPEDRRSVLVSLTEEGRELIEQ 80

                           90       100
                   ....*....|....*....|.
gi 1402977453  104 FKQDRNQFVHQMLLDFSEEEV 124
Cdd:smart00347  81 LLEARSETLAELLAGLTAEEQ 101
MarR pfam01047
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 31-89 2.92e-12

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 426012 [Multi-domain]  Cd Length: 59  Bit Score: 57.56  E-value: 2.92e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1402977453  31 ISSSRYVLLYHLYIHEEVTQSHLQKAIHIDSAAITRHLKQLEADGLVSRRRNPIDQRET 89
Cdd:pfam01047   1 LTLTQFHILRILYEHGPLTVSELAEKLGVSKSTVTRVLDRLEKKGLIERSRSPEDRREV 59
MarR_2 pfam12802
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 29-88 1.56e-11

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 432797 [Multi-domain]  Cd Length: 60  Bit Score: 55.67  E-value: 1.56e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402977453  29 TGISSSRYVLLYHLYIHEEVTQSHLQKAIHIDSAAITRHLKQLEADGLVSRRRNPIDQRE 88
Cdd:pfam12802   1 LGLTPAQFRVLLALARNPGLTVAELARRLGISKQTVSRLVKRLEAKGLVEREPSPADRRA 60
PRK03573 PRK03573
transcriptional regulator SlyA; Provisional
 17-141 4.16e-09

transcriptional regulator SlyA; Provisional


Pssm-ID: 179596  Cd Length: 144  Bit Score: 51.54  E-value: 4.16e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402977453  17 ISNQLKPkfercTGISSSRYVLLYHLY-IHEEVTQSHLQKAIHIDSAAITRHLKQLEADGLVSRRRNPIDQRETFVRLTE 95
Cdd:PRK03573   20 IDHRLKP-----LELTQTHWVTLHNIHqLPPEQSQIQLAKAIGIEQPSLVRTLDQLEEKGLISRQTCASDRRAKRIKLTE 94

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1402977453  96 QGLTHIANFKQDRNQFVHQMLLDFSEEEVAMMTDMLARMQFNMKDM 141
Cdd:PRK03573   95 KAEPLISEVEAVINKTRAEILHGISAEEIEQLITLIAKLEKNIIEL 140
PRK11512 PRK11512
multiple antibiotic resistance transcriptional regulator MarR;
31-134 1.72e-08

multiple antibiotic resistance transcriptional regulator MarR;


Pssm-ID: 183170  Cd Length: 144  Bit Score: 49.90  E-value: 1.72e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402977453  31 ISSSRYVLLYHLYIHEEVTQSHLQKAIHIDSAAITRHLKQLEADGLVSRRRNPIDQRETFVRLTEQGLTHIANFKQDRNQ 110
Cdd:PRK11512   38 ITAAQFKVLCSIRCAACITPVELKKVLSVDLGALTRMLDRLVCKGWVERLPNPNDKRGVLVKLTTSGAAICEQCHQLVGQ 117

                          90       100
                  ....*....|....*....|....*
gi 1402977453 111 FVHQMLL-DFSEEEVAMMTDMLARM 134
Cdd:PRK11512  118 DLHQELTkNLTADEVATLEHLLKKV 142
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 32-95 8.87e-07

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 43.83  E-value: 8.87e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1402977453  32 SSSRYVLLYHLYiHEEVTQSHLQKAIHIDSAAITRHLKQLEADGLVSRRRnpiDQRETFVRLTE 95
Cdd:cd00090     6 DPTRLRILRLLL-EGPLTVSELAERLGLSQSTVSRHLKKLEEAGLVESRR---EGRRVYYSLTD 65
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
1-104 2.59e-06

DNA-binding transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 42.95  E-value: 2.59e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402977453   1 MNCSLEQENLLILLKNISNQlkpkferctgissSRYVLLYHLyIHEEVTQSHLQKAIHIDSAAITRHLKQLEADGLVSRR 80
Cdd:COG0640     1 MSETKELEELAELFKALADP-------------TRLRILRLL-AEGELCVGELAEALGLSQSTVSHHLKVLREAGLVTSR 66

                          90       100
                  ....*....|....*....|....
gi 1402977453  81 RnpiDQRETFVRLTEQGLTHIANF 104
Cdd:COG0640    67 R---EGRWVYYRLADEALAELLEW 87
COG3398 COG3398
Predicted transcriptional regulator, contains two HTH domains [Transcription];
33-95 1.72e-05

Predicted transcriptional regulator, contains two HTH domains [Transcription];


Pssm-ID: 442625 [Multi-domain]  Cd Length: 159  Bit Score: 42.17  E-value: 1.72e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1402977453  33 SSRYVLLYhLYIHEEVTQSHLQKAIHIDSAAITRHLKQLEADGLVSRRRnpiDQRETFVRLTE 95
Cdd:COG3398    98 TPRRILLY-LLENPGATNKELAEELGISRSTVSWHLKRLEEDGLVERER---DGRNVRYYLNP 156
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
38-95 2.61e-05

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 39.89  E-value: 2.61e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1402977453   38 LLYHLYiHEEVTQSHLQKAIHIDSAAITRHLKQLEADGLVSRRRnpiDQRETFVRLTE 95
Cdd:smart00418   2 ILKLLA-EGELCVCELAEILGLSQSTVSHHLKKLREAGLVESRR---EGKRVYYSLTD 55
COG2512 COG2512
Predicted transcriptional regulator, contains CW (cell wall-binding) repeats and an HTH domain ...
 47-100 2.69e-05

Predicted transcriptional regulator, contains CW (cell wall-binding) repeats and an HTH domain [General function prediction only];


Pssm-ID: 442002 [Multi-domain]  Cd Length: 80  Bit Score: 39.90  E-value: 2.69e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1402977453  47 EVTQSHLQKAIHIDSAAITRHLKQLEADGLVSRRRnpiDQRETFVRLTEQGLTH 100
Cdd:COG2512    30 RMTQSEIVKETGWSKSKVSRLLSRLEERGLIEKER---VGRENVVELPEDEPEA 80
Staph_reg_Sar TIGR01889
staphylococcal accessory regulator family; This model represents a family of transcriptional ...
 8-111 8.06e-05

staphylococcal accessory regulator family; This model represents a family of transcriptional regulatory proteins in Staphylococcus aureus and Staphylococcus epidermidis. Some members contain two tandem copies of this region. This family is related to the MarR transcriptional regulator family described by pfam01047. [Regulatory functions, DNA interactions]


Pssm-ID: 130944  Cd Length: 109  Bit Score: 39.55  E-value: 8.06e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402977453   8 ENLLILLKNISNQLKPKFerctGISSSRYVLLYHLYIHE----EVTQSHLQKAIHIDSAAITRHLKQLEADGLVSRRRNP 83
Cdd:TIGR01889   4 LSLYLYIKSLKRYLKKEF----NLSLEELLILYYLGKLEnnegKLTLKEIIKEILIKQSALVKIIKKLSKKGYLSKERSE 79

                          90       100
                  ....*....|....*....|....*...
gi 1402977453  84 IDQRETFVRLTEQGLTHIANFKQDRNQF 111
Cdd:TIGR01889  80 DDERKVIISINKEQRSKIESLISEIEQI 107
HTH_27 pfam13463
Winged helix DNA-binding domain;
37-97 1.48e-04

Winged helix DNA-binding domain;


Pssm-ID: 433228 [Multi-domain]  Cd Length: 68  Bit Score: 37.65  E-value: 1.48e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1402977453  37 VLLYHLYI-HEEVTQSHLQKAIHIDSAAITRHLKQLEADGLVSRRRNPIDQRETFVRLTEQG 97
Cdd:pfam13463   7 LILHNIGHrGDPKTLADICFRLNVEDSHVSYSLKKLTEAGLVEREGSEEDGRETRVRLTAKG 68
HTH_20 pfam12840
Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in ...
 32-81 2.06e-04

Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in transcriptional regulatory proteins.


Pssm-ID: 432824 [Multi-domain]  Cd Length: 61  Bit Score: 37.13  E-value: 2.06e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1402977453  32 SSSRYVLLYHLYIHEEVTQSHLQKAIHIDSAAITRHLKQLEADGLVSRRR 81
Cdd:pfam12840   9 DPTRLRILRALVGDEPLTASELARRLDISRNTLSYHLRKLEEAGLVEVVR 58
COG2345 COG2345
Predicted transcriptional regulator, ArsR family [Transcription];
32-81 2.73e-04

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 441914 [Multi-domain]  Cd Length: 217  Bit Score: 39.14  E-value: 2.73e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1402977453  32 SSSRYVLLYHLYIHEEVTQSHLQKAIHIDSAAITRHLKQLEADGLVSRRR 81
Cdd:COG2345    12 DPTRRRILELLKRAGPVTAAELAEALGLTPNAVRRHLDALEEEGLVERET 61
HTH_metalloreg NF033788
metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense ...
 35-81 8.84e-04

metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense toxic heavy metals such as arsenic or cadmium, and are released from DNA so that resistance factors will be expressed, include ArsR, SmtB, ZiaR, CadC, CadX, KmtR, etc. However, some members of this family, including the sporulation delaying system autorepressor SdpR and its family (see NF033789), may lack metal-binding cites and instead regulate other cellular processes.


Pssm-ID: 411368 [Multi-domain]  Cd Length: 76  Bit Score: 35.90  E-value: 8.84e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1402977453  35 RYVLLYHLyIHEEVTQSHLQKAIHIDSAAITRHLKQLEADGLVSRRR 81
Cdd:NF033788   13 RLRILELL-AEGELCVCELAEALGLSQSAVSQHLKVLRDAGLVTSRR 58
HTH_34 pfam13601
Winged helix DNA-binding domain;
35-98 2.94e-03

Winged helix DNA-binding domain;


Pssm-ID: 463932 [Multi-domain]  Cd Length: 80  Bit Score: 34.54  E-value: 2.94e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1402977453  35 RYVLLYHLYIHEEVTQSHLQKAIHIDSAAITRHLKQLEADGLVSRRRNPIDQRE-TFVRLTEQGL 98
Cdd:pfam13601   2 RLAIMSYLASVDEADFVELKEALEATDGNLSVHLRKLEKAGYIECDKSFVGRKPrTLYRITPEGR 66
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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