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Conserved domains on  [gi|1407166161|ref|WP_111089262|]
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GntR family transcriptional regulator [Curtobacterium sp. MCLR17_055]

Protein Classification

GntR family transcriptional regulator( domain architecture ID 11448455)

GntR-family transcriptional regulator is one of a group of transcriptional regulators with a conserved N-terminal helix-turn-helix DNA-binding domain and a diverse C-terminal effector-binding and oligomerization domain; controls the expression of genes with diverse biological functions

CATH:  1.10.10.10
Gene Ontology:  GO:0003700|GO:0003677
PubMed:  33509775
SCOP:  4000155

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GntR COG1802
DNA-binding transcriptional regulator, GntR family [Transcription];
6-221 1.20e-26

DNA-binding transcriptional regulator, GntR family [Transcription];


:

Pssm-ID: 441407 [Multi-domain]  Cd Length: 222  Bit Score: 101.92  E-value: 1.20e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1407166161   6 STVESSPRKLLRDVVYDKMLAALRDGTLQHGERLNDDELVQWLGVSRTPIREAIAKLVDIGLVEMEANRYTRVATPTFED 85
Cdd:COG1802     2 TSPSPLRRESLAEQVYEALREAILSGELPPGERLSEAELAERLGVSRTPVREALRRLEAEGLVEIRPNRGARVAPLSPEE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1407166161  86 WVTATRATAGFFELSLRWGVPEYSDEDVEALTVLLDKADRMRKVRDY-GFSGALTEIIEFAVEHSGNPLVQNAA---VGA 161
Cdd:COG1802    82 IRELYEVRAALEGLAARLAAERATPADLARLRALLEELEAAAAAGDVaAYLELDREFHRALVEAAGNPRLAELLrrlRAR 161

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1407166161 162 MERVRFTLNPTPAFEQYGSEAFFSILrEALSERDGEGAAEAGRALTRNFEQHIEAVRADR 221
Cdd:COG1802   162 LRRYRRLSLRSPGRLEESLAEHRAIL-DALEAGDAEAAAAALRAHLERARERLLEALAAA 220
 
Name Accession Description Interval E-value
GntR COG1802
DNA-binding transcriptional regulator, GntR family [Transcription];
6-221 1.20e-26

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441407 [Multi-domain]  Cd Length: 222  Bit Score: 101.92  E-value: 1.20e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1407166161   6 STVESSPRKLLRDVVYDKMLAALRDGTLQHGERLNDDELVQWLGVSRTPIREAIAKLVDIGLVEMEANRYTRVATPTFED 85
Cdd:COG1802     2 TSPSPLRRESLAEQVYEALREAILSGELPPGERLSEAELAERLGVSRTPVREALRRLEAEGLVEIRPNRGARVAPLSPEE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1407166161  86 WVTATRATAGFFELSLRWGVPEYSDEDVEALTVLLDKADRMRKVRDY-GFSGALTEIIEFAVEHSGNPLVQNAA---VGA 161
Cdd:COG1802    82 IRELYEVRAALEGLAARLAAERATPADLARLRALLEELEAAAAAGDVaAYLELDREFHRALVEAAGNPRLAELLrrlRAR 161

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1407166161 162 MERVRFTLNPTPAFEQYGSEAFFSILrEALSERDGEGAAEAGRALTRNFEQHIEAVRADR 221
Cdd:COG1802   162 LRRYRRLSLRSPGRLEESLAEHRAIL-DALEAGDAEAAAAALRAHLERARERLLEALAAA 220
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 16-79 3.07e-12

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 59.77  E-value: 3.07e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1407166161  16 LRDVVYDKMLAALRDGTLQHGERL-NDDELVQWLGVSRTPIREAIAKLVDIGLVEMEANRYTRVA 79
Cdd:cd07377     2 LYEQIADQLREAILSGELKPGDRLpSERELAEELGVSRTTVREALRELEAEGLVERRPGRGTFVA 66
PRK03837 PRK03837
transcriptional regulator NanR; Provisional
 13-219 2.49e-11

transcriptional regulator NanR; Provisional


Pssm-ID: 235166 [Multi-domain]  Cd Length: 241  Bit Score: 61.19  E-value: 2.49e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1407166161  13 RKLLRDVVYDKMLAALRDGTLQHGERL-NDDELVQWLGVSRTPIREAIAKLVDIGLVEMEANRYTRVATPTFEDWVTATR 91
Cdd:PRK03837   11 RKKLSEEVEERLEQMIRSGEFGPGDQLpSERELMAFFGVGRPAVREALQALKRKGLVQISHGERARVSRPSADTIIGQLS 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1407166161  92 ATAG------------------FFELSL-RWGVPEYSDEDVEALTVLL-------DKADRMRKvRDYGFSGALTEIiefa 145
Cdd:PRK03837   91 GMAKdflsqspdglahlkqarlFFESSLaRYAAEHATDEQIALLRKALernsqslGDNAAFIR-SDMEFHRVIAEI---- 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1407166161 146 vehSGNPL---VQNAAVGAMERVRftlnpTPAFEQYGSEAF-----FSILrEALSERDGEGAAeagRALTRnfeqHIEAV 217
Cdd:PRK03837  166 ---PGNPIfmaIHEALLDWLIEAR-----PEVVILHGHENVtlqehIAIV-DAIRAHDPDEAD---RALQS----HLNRV 229


                  ..
gi 1407166161 218 RA 219
Cdd:PRK03837  230 SA 231
GntR pfam00392
Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the ...
 16-78 1.68e-09

Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the N-terminal HTH region of GntR-like bacterial transcription factors. At the C-terminus there is usually an effector-binding/oligomerization domain. The GntR-like proteins include the following sub-families: MocR, YtrR, FadR, AraR, HutC and PlmA, DevA, DasR. Many of these proteins have been shown experimentally to be autoregulatory, enabling the prediction of operator sites and the discovery of cis/trans relationships. The DasR regulator has been shown to be a global regulator of primary metabolism and development in Streptomyces coelicolor.


Pssm-ID: 306822 [Multi-domain]  Cd Length: 64  Bit Score: 52.23  E-value: 1.68e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1407166161  16 LRDVVYDKMLAALRDGTLQHGERLN-DDELVQWLGVSRTPIREAIAKLVDIGLVEMEANRYTRV 78
Cdd:pfam00392   1 LYEQVYARLREDILSGRLRPGDKLPsERELAAEFGVSRTTVREALRRLEAEGLVERRQGRGTFV 64
HTH_GNTR smart00345
helix_turn_helix gluconate operon transcriptional repressor;
20-78 3.40e-08

helix_turn_helix gluconate operon transcriptional repressor;


Pssm-ID: 197669 [Multi-domain]  Cd Length: 60  Bit Score: 48.73  E-value: 3.40e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1407166161   20 VYDKMLAALRDGTLQHGERL-NDDELVQWLGVSRTPIREAIAKLVDIGLVEMEANRYTRV 78
Cdd:smart00345   1 VAERLREDIVSGELRPGDKLpSERELAAQLGVSRTTVREALSRLEAEGLVQRRPGSGTFV 60
 
Name Accession Description Interval E-value
GntR COG1802
DNA-binding transcriptional regulator, GntR family [Transcription];
6-221 1.20e-26

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441407 [Multi-domain]  Cd Length: 222  Bit Score: 101.92  E-value: 1.20e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1407166161   6 STVESSPRKLLRDVVYDKMLAALRDGTLQHGERLNDDELVQWLGVSRTPIREAIAKLVDIGLVEMEANRYTRVATPTFED 85
Cdd:COG1802     2 TSPSPLRRESLAEQVYEALREAILSGELPPGERLSEAELAERLGVSRTPVREALRRLEAEGLVEIRPNRGARVAPLSPEE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1407166161  86 WVTATRATAGFFELSLRWGVPEYSDEDVEALTVLLDKADRMRKVRDY-GFSGALTEIIEFAVEHSGNPLVQNAA---VGA 161
Cdd:COG1802    82 IRELYEVRAALEGLAARLAAERATPADLARLRALLEELEAAAAAGDVaAYLELDREFHRALVEAAGNPRLAELLrrlRAR 161

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1407166161 162 MERVRFTLNPTPAFEQYGSEAFFSILrEALSERDGEGAAEAGRALTRNFEQHIEAVRADR 221
Cdd:COG1802   162 LRRYRRLSLRSPGRLEESLAEHRAIL-DALEAGDAEAAAAALRAHLERARERLLEALAAA 220
FadR COG2186
DNA-binding transcriptional regulator, FadR family [Transcription];
9-222 1.73e-12

DNA-binding transcriptional regulator, FadR family [Transcription];


Pssm-ID: 441789 [Multi-domain]  Cd Length: 232  Bit Score: 64.18  E-value: 1.73e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1407166161   9 ESSPRKLLRDVVYDKMLAALRDGTLQHGERL-NDDELVQWLGVSRTPIREAIAKLVDIGLVEMEANRYTRVATPTFEDWV 87
Cdd:COG2186     1 KPIRRRSLAEQVAEQLRELILSGELKPGDRLpSERELAEQLGVSRTTVREALRALEALGLVEVRQGGGTFVREPSPWALL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1407166161  88 TATRATAGFFELSL------RWGV-PEY--------SDEDVEALTVLLdkaDRMRKVRDygfSGALTEIIEFA-----VE 147
Cdd:COG2186    81 DPLALLLALDDASLrdlleaRLALePEAarlaaeraTDEDLARLEAAL---AEMEAAAD---DGEAFAEADLAfhraiAE 154

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1407166161 148 HSGNPL---VQNAAVGAMERVRFTLNPTPAFEQYGSEAFFSILrEALSERDGEGAAEAGRALTRNFEQHIEAVRADRG 222
Cdd:COG2186   155 ASGNPLlalLLESLRELLRRSVRLTLRSPEARERSLAEHRAIL-DAIRAGDPEAARAAMRAHLEAVRERLREALAERA 231
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 16-79 3.07e-12

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 59.77  E-value: 3.07e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1407166161  16 LRDVVYDKMLAALRDGTLQHGERL-NDDELVQWLGVSRTPIREAIAKLVDIGLVEMEANRYTRVA 79
Cdd:cd07377     2 LYEQIADQLREAILSGELKPGDRLpSERELAEELGVSRTTVREALRELEAEGLVERRPGRGTFVA 66
PRK03837 PRK03837
transcriptional regulator NanR; Provisional
 13-219 2.49e-11

transcriptional regulator NanR; Provisional


Pssm-ID: 235166 [Multi-domain]  Cd Length: 241  Bit Score: 61.19  E-value: 2.49e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1407166161  13 RKLLRDVVYDKMLAALRDGTLQHGERL-NDDELVQWLGVSRTPIREAIAKLVDIGLVEMEANRYTRVATPTFEDWVTATR 91
Cdd:PRK03837   11 RKKLSEEVEERLEQMIRSGEFGPGDQLpSERELMAFFGVGRPAVREALQALKRKGLVQISHGERARVSRPSADTIIGQLS 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1407166161  92 ATAG------------------FFELSL-RWGVPEYSDEDVEALTVLL-------DKADRMRKvRDYGFSGALTEIiefa 145
Cdd:PRK03837   91 GMAKdflsqspdglahlkqarlFFESSLaRYAAEHATDEQIALLRKALernsqslGDNAAFIR-SDMEFHRVIAEI---- 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1407166161 146 vehSGNPL---VQNAAVGAMERVRftlnpTPAFEQYGSEAF-----FSILrEALSERDGEGAAeagRALTRnfeqHIEAV 217
Cdd:PRK03837  166 ---PGNPIfmaIHEALLDWLIEAR-----PEVVILHGHENVtlqehIAIV-DAIRAHDPDEAD---RALQS----HLNRV 229


                  ..
gi 1407166161 218 RA 219
Cdd:PRK03837  230 SA 231
GntR pfam00392
Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the ...
 16-78 1.68e-09

Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the N-terminal HTH region of GntR-like bacterial transcription factors. At the C-terminus there is usually an effector-binding/oligomerization domain. The GntR-like proteins include the following sub-families: MocR, YtrR, FadR, AraR, HutC and PlmA, DevA, DasR. Many of these proteins have been shown experimentally to be autoregulatory, enabling the prediction of operator sites and the discovery of cis/trans relationships. The DasR regulator has been shown to be a global regulator of primary metabolism and development in Streptomyces coelicolor.


Pssm-ID: 306822 [Multi-domain]  Cd Length: 64  Bit Score: 52.23  E-value: 1.68e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1407166161  16 LRDVVYDKMLAALRDGTLQHGERLN-DDELVQWLGVSRTPIREAIAKLVDIGLVEMEANRYTRV 78
Cdd:pfam00392   1 LYEQVYARLREDILSGRLRPGDKLPsERELAAEFGVSRTTVREALRRLEAEGLVERRQGRGTFV 64
HTH_GNTR smart00345
helix_turn_helix gluconate operon transcriptional repressor;
20-78 3.40e-08

helix_turn_helix gluconate operon transcriptional repressor;


Pssm-ID: 197669 [Multi-domain]  Cd Length: 60  Bit Score: 48.73  E-value: 3.40e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1407166161   20 VYDKMLAALRDGTLQHGERL-NDDELVQWLGVSRTPIREAIAKLVDIGLVEMEANRYTRV 78
Cdd:smart00345   1 VAERLREDIVSGELRPGDKLpSERELAAQLGVSRTTVREALSRLEAEGLVQRRPGSGTFV 60
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
20-91 8.93e-07

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 47.93  E-value: 8.93e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1407166161  20 VYDKMLAALRDGTLQHGERL-NDDELVQWLGVSRTPIREAIAKLVDIGLVEMEANRYTRVATPTFEDWVTATR 91
Cdd:COG2188    10 IADALRERIESGELPPGDRLpSERELAEEFGVSRMTVRKALDELVEEGLLERRQGRGTFVAEPKIEYPLSRLT 82
PRK10421 PRK10421
DNA-binding transcriptional repressor LldR; Provisional
 16-86 2.27e-05

DNA-binding transcriptional repressor LldR; Provisional


Pssm-ID: 236690 [Multi-domain]  Cd Length: 253  Bit Score: 43.99  E-value: 2.27e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1407166161  16 LRDVVYDKMLAALRDGTLQHGERL-NDDELVQWLGVSRTPIREAIAKLVDIGLVEmeanryTRVATPTF-----EDW 86
Cdd:PRK10421    3 LSDEVADRVRALIEEKNLEAGMKLpAERQLAMQLGVSRNSLREALAKLVSEGVLL------SRRGGGTFirwrhETW 73
ARO8 COG1167
DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain ...
 20-81 5.72e-04

DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain [Transcription, Amino acid transport and metabolism]; DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain is part of the Pathway/BioSystem: Lysine biosynthesis


Pssm-ID: 440781 [Multi-domain]  Cd Length: 471  Bit Score: 40.20  E-value: 5.72e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1407166161  20 VYDKMLAALRDGTLQHGERLnd-dELVQWLGVSRTPIREAIAKLVDIGLVEMEANRYTRVATP 81
Cdd:COG1167    17 LADALREAILSGRLPPGDRLpssrELAAQLGVSRSTVVRAYEELEAEGLIESRPGSGTFVAAR 79
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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