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Conserved domains on  [gi|1421682225|ref|WP_111823653|]
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WecB/TagA/CpsF family glycosyltransferase [Schaalia odontolytica]

Protein Classification

WecB/TagA/CpsF family glycosyltransferase( domain architecture ID 10158400)

WecB/TagA/CpsF family glycosyltransferase catalyzes the formation of glycosidic bonds and may be involved in the biosynthesis of repeating polysaccharide units found in membrane glycolipids

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Glyco_transf_WecG_TagA cd06533
The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus ...
 62-226 3.53e-26

The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common antigen (eca) synthesis. B. subtilis TagA plays a key role in the Wall Teichoic Acid (WTA) biosynthetic pathway, catalyzing the transfer of N-acetylmannosamine to the C4 hydroxyl of a membrane-anchored N-acetylglucosaminyl diphospholipid to make ManNAc-beta-(1,4)-GlcNAc-pp-undecaprenyl. This is the first committed step in this pathway. Also included in this group is Xanthomonas campestris pv. campestris GumM, a glycosyltransferase participating in the biosynthesis of the exopolysaccharide xanthan.


:

Pssm-ID: 119439  Cd Length: 171  Bit Score: 100.62  E-value: 3.53e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1421682225  62 LARMHAVGFDGTLLQLRLRAAGHEVAR--TSADLVlPHVFDRLDD-GCRITLIGAVPEAGQAAAERL--DRFDVQVIDGY 136
Cdd:cd06533     1 LNSADLVLPDGIGVVWAARLLGGPLPErvTGSDLM-PALLELAAQkGLRVFLLGAKPEVLEKAAERLraRYPGLKIVGYH 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1421682225 137 DGLRRFKADPSVL---TAFDPRLVIVGLGAGLQEVVASVALDLVPESSVCTAGGWIDQFARAADDYfPDWVHAARLGWAW 213
Cdd:cd06533    80 HGYFGPEEEEEIIeriNASGADILFVGLGAPKQELWIARHKDRLPVPVAIGVGGSFDFLAGTVKRA-PKWMQKLGLEWLY 158

                         170
                  ....*....|...
gi 1421682225 214 RIAHEPKRLTKRY 226
Cdd:cd06533   159 RLLQEPRRLWRRY 171
 
Name Accession Description Interval E-value
Glyco_transf_WecG_TagA cd06533
The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus ...
 62-226 3.53e-26

The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common antigen (eca) synthesis. B. subtilis TagA plays a key role in the Wall Teichoic Acid (WTA) biosynthetic pathway, catalyzing the transfer of N-acetylmannosamine to the C4 hydroxyl of a membrane-anchored N-acetylglucosaminyl diphospholipid to make ManNAc-beta-(1,4)-GlcNAc-pp-undecaprenyl. This is the first committed step in this pathway. Also included in this group is Xanthomonas campestris pv. campestris GumM, a glycosyltransferase participating in the biosynthesis of the exopolysaccharide xanthan.


Pssm-ID: 119439  Cd Length: 171  Bit Score: 100.62  E-value: 3.53e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1421682225  62 LARMHAVGFDGTLLQLRLRAAGHEVAR--TSADLVlPHVFDRLDD-GCRITLIGAVPEAGQAAAERL--DRFDVQVIDGY 136
Cdd:cd06533     1 LNSADLVLPDGIGVVWAARLLGGPLPErvTGSDLM-PALLELAAQkGLRVFLLGAKPEVLEKAAERLraRYPGLKIVGYH 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1421682225 137 DGLRRFKADPSVL---TAFDPRLVIVGLGAGLQEVVASVALDLVPESSVCTAGGWIDQFARAADDYfPDWVHAARLGWAW 213
Cdd:cd06533    80 HGYFGPEEEEEIIeriNASGADILFVGLGAPKQELWIARHKDRLPVPVAIGVGGSFDFLAGTVKRA-PKWMQKLGLEWLY 158

                         170
                  ....*....|...
gi 1421682225 214 RIAHEPKRLTKRY 226
Cdd:cd06533   159 RLLQEPRRLWRRY 171
Glyco_tran_WecG pfam03808
Glycosyl transferase WecG/TagA/CpsF family; The WecG member of this family, believed to be ...
 71-226 2.71e-21

Glycosyl transferase WecG/TagA/CpsF family; The WecG member of this family, believed to be UDP-N-acetyl-D-mannosaminuronic acid transferase, plays a role in enterobacterial common antigen (eca) synthesis in Escherichia coli. Another family member, the Bacillus subtilis TagA protein, is involved in the biosynthesis of the cell wall polymer poly(glycerol phosphate). The third family member, CpsF, CMP-N-acetylneuraminic acid synthetase has a role in the capsular polysaccharide biosynthesis pathway. Also included in this group is Xanthomonas campestris pv. campestris GumM, a glycosyltransferase participating in the biosynthesis of the exopolysaccharide xanthan.


Pssm-ID: 461059  Cd Length: 168  Bit Score: 87.52  E-value: 2.71e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1421682225  71 DGTLLQLRLRAAGHEVAR--TSADLVlPHVFDRLDD-GCRITLIGAVPEAGQAAAERL-DRF-DVQVIDGYDGLRRFKAD 145
Cdd:pfam03808   7 DGIGVVWAARLLGRPLPErvAGSDLF-PALLEAAARrGLRVFLLGGKPGVAEKAAENLrQRYpGLRIAGRHHGYFGKEEE 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1421682225 146 PSVLT---AFDPRLVIVGLGAGLQEVVASVALDLVPESSVCTAGGWIDQFA----RAaddyfPDWVHAARLGWAWRIAHE 218
Cdd:pfam03808  86 EAIIEainASGPDILFVGLGAPKQEKWIARNRDGLPVAVIIGVGGSFDFLAgrvkRA-----PRWMQRLGLEWLYRLLQE 160


                  ....*...
gi 1421682225 219 PKRLTKRY 226
Cdd:pfam03808 161 PKRLWRRY 168
WecG COG1922
UDP-N-acetyl-D-mannosaminuronic acid transferase, WecB/TagA/CpsF family [Cell wall/membrane ...
 71-237 6.99e-20

UDP-N-acetyl-D-mannosaminuronic acid transferase, WecB/TagA/CpsF family [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441525  Cd Length: 244  Bit Score: 85.59  E-value: 6.99e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1421682225  71 DGTLLQLRLRAAGHEVAR--TSADLVlPHVFDRLDD-GCRITLIGAVPEAGQAAAERL-DRF-DVQVIDGYDGLRRFKAD 145
Cdd:COG1922    65 DGIGVVWAARLLGRPLPErvTGSDLM-PALLERAAEkGLRVFLLGGKPGVAEKAAANLrQRYpGLRIAGTHHGYFRFPEE 143

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1421682225 146 PSVL----TAFDPRLVIVGLGAGLQEVVASVALDLVPESSVCTAGGWIDQFA----RAaddyfPDWVHAARLGWAWRIAH 217
Cdd:COG1922   144 EEAIieriNASGPDILFVGLGAPKQEKWIARNRDRLPVAVIIGVGGAFDFLAgtvkRA-----PRWMQRLGLEWLYRLLQ 218

                         170       180
                  ....*....|....*....|
gi 1421682225 218 EPKRLTKRYTVEALDFVAHA 237
Cdd:COG1922   219 EPRRLWRRYLLPNPLFLLLV 238
wecG_tagA_cpsF TIGR00696
bacterial polymer biosynthesis proteins, WecB/TagA/CpsF family; The WecG member of this ...
 107-228 2.86e-05

bacterial polymer biosynthesis proteins, WecB/TagA/CpsF family; The WecG member of this superfamily, believed to be UDP-N-acetyl-D-mannosaminuronic acid transferase, plays a role in enterobacterial common antigen (eca) synthesis in Escherichia coli. Another family member, the Bacillus subtilis TagA protein, is involved in the biosynthesis of the cell wall polymer poly(glycerol phosphate). The third family member, CpsF, CMP-N-acetylneuraminic acid synthetase has a role in the capsular polysaccharide biosynthesis pathway. [Cell envelope, Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides]


Pssm-ID: 129779  Cd Length: 177  Bit Score: 43.63  E-value: 2.86e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1421682225 107 RITLIGAVPEAGQAAAERL-DRFDVQVIDGYDGL---RRFKADPSVLTAFDPRLVIVGLGAGLQEVVASVALDLVPESSV 182
Cdd:TIGR00696  50 PIFLYGGKPDVLQQLKVKLiKEYPKLKIVGAFGPlepEERKAALAKIARSGAGIVFVGLGCPKQEIWMRNHRHLKPDAVM 129

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1421682225 183 CTAGGWIDQFA----RAaddyfPDWVHAARLGWAWRIAHEPKRLTKRYTV 228
Cdd:TIGR00696 130 IGVGGSFDVFSglvkRA-----PRWLMRLGLEWLYRLRMEPWRWKRMLLI 174
 
Name Accession Description Interval E-value
Glyco_transf_WecG_TagA cd06533
The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus ...
 62-226 3.53e-26

The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common antigen (eca) synthesis. B. subtilis TagA plays a key role in the Wall Teichoic Acid (WTA) biosynthetic pathway, catalyzing the transfer of N-acetylmannosamine to the C4 hydroxyl of a membrane-anchored N-acetylglucosaminyl diphospholipid to make ManNAc-beta-(1,4)-GlcNAc-pp-undecaprenyl. This is the first committed step in this pathway. Also included in this group is Xanthomonas campestris pv. campestris GumM, a glycosyltransferase participating in the biosynthesis of the exopolysaccharide xanthan.


Pssm-ID: 119439  Cd Length: 171  Bit Score: 100.62  E-value: 3.53e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1421682225  62 LARMHAVGFDGTLLQLRLRAAGHEVAR--TSADLVlPHVFDRLDD-GCRITLIGAVPEAGQAAAERL--DRFDVQVIDGY 136
Cdd:cd06533     1 LNSADLVLPDGIGVVWAARLLGGPLPErvTGSDLM-PALLELAAQkGLRVFLLGAKPEVLEKAAERLraRYPGLKIVGYH 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1421682225 137 DGLRRFKADPSVL---TAFDPRLVIVGLGAGLQEVVASVALDLVPESSVCTAGGWIDQFARAADDYfPDWVHAARLGWAW 213
Cdd:cd06533    80 HGYFGPEEEEEIIeriNASGADILFVGLGAPKQELWIARHKDRLPVPVAIGVGGSFDFLAGTVKRA-PKWMQKLGLEWLY 158

                         170
                  ....*....|...
gi 1421682225 214 RIAHEPKRLTKRY 226
Cdd:cd06533   159 RLLQEPRRLWRRY 171
Glyco_tran_WecG pfam03808
Glycosyl transferase WecG/TagA/CpsF family; The WecG member of this family, believed to be ...
 71-226 2.71e-21

Glycosyl transferase WecG/TagA/CpsF family; The WecG member of this family, believed to be UDP-N-acetyl-D-mannosaminuronic acid transferase, plays a role in enterobacterial common antigen (eca) synthesis in Escherichia coli. Another family member, the Bacillus subtilis TagA protein, is involved in the biosynthesis of the cell wall polymer poly(glycerol phosphate). The third family member, CpsF, CMP-N-acetylneuraminic acid synthetase has a role in the capsular polysaccharide biosynthesis pathway. Also included in this group is Xanthomonas campestris pv. campestris GumM, a glycosyltransferase participating in the biosynthesis of the exopolysaccharide xanthan.


Pssm-ID: 461059  Cd Length: 168  Bit Score: 87.52  E-value: 2.71e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1421682225  71 DGTLLQLRLRAAGHEVAR--TSADLVlPHVFDRLDD-GCRITLIGAVPEAGQAAAERL-DRF-DVQVIDGYDGLRRFKAD 145
Cdd:pfam03808   7 DGIGVVWAARLLGRPLPErvAGSDLF-PALLEAAARrGLRVFLLGGKPGVAEKAAENLrQRYpGLRIAGRHHGYFGKEEE 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1421682225 146 PSVLT---AFDPRLVIVGLGAGLQEVVASVALDLVPESSVCTAGGWIDQFA----RAaddyfPDWVHAARLGWAWRIAHE 218
Cdd:pfam03808  86 EAIIEainASGPDILFVGLGAPKQEKWIARNRDGLPVAVIIGVGGSFDFLAgrvkRA-----PRWMQRLGLEWLYRLLQE 160


                  ....*...
gi 1421682225 219 PKRLTKRY 226
Cdd:pfam03808 161 PKRLWRRY 168
WecG COG1922
UDP-N-acetyl-D-mannosaminuronic acid transferase, WecB/TagA/CpsF family [Cell wall/membrane ...
 71-237 6.99e-20

UDP-N-acetyl-D-mannosaminuronic acid transferase, WecB/TagA/CpsF family [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441525  Cd Length: 244  Bit Score: 85.59  E-value: 6.99e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1421682225  71 DGTLLQLRLRAAGHEVAR--TSADLVlPHVFDRLDD-GCRITLIGAVPEAGQAAAERL-DRF-DVQVIDGYDGLRRFKAD 145
Cdd:COG1922    65 DGIGVVWAARLLGRPLPErvTGSDLM-PALLERAAEkGLRVFLLGGKPGVAEKAAANLrQRYpGLRIAGTHHGYFRFPEE 143

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1421682225 146 PSVL----TAFDPRLVIVGLGAGLQEVVASVALDLVPESSVCTAGGWIDQFA----RAaddyfPDWVHAARLGWAWRIAH 217
Cdd:COG1922   144 EEAIieriNASGPDILFVGLGAPKQEKWIARNRDRLPVAVIIGVGGAFDFLAgtvkRA-----PRWMQRLGLEWLYRLLQ 218

                         170       180
                  ....*....|....*....|
gi 1421682225 218 EPKRLTKRYTVEALDFVAHA 237
Cdd:COG1922   219 EPRRLWRRYLLPNPLFLLLV 238
wecG_tagA_cpsF TIGR00696
bacterial polymer biosynthesis proteins, WecB/TagA/CpsF family; The WecG member of this ...
 107-228 2.86e-05

bacterial polymer biosynthesis proteins, WecB/TagA/CpsF family; The WecG member of this superfamily, believed to be UDP-N-acetyl-D-mannosaminuronic acid transferase, plays a role in enterobacterial common antigen (eca) synthesis in Escherichia coli. Another family member, the Bacillus subtilis TagA protein, is involved in the biosynthesis of the cell wall polymer poly(glycerol phosphate). The third family member, CpsF, CMP-N-acetylneuraminic acid synthetase has a role in the capsular polysaccharide biosynthesis pathway. [Cell envelope, Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides]


Pssm-ID: 129779  Cd Length: 177  Bit Score: 43.63  E-value: 2.86e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1421682225 107 RITLIGAVPEAGQAAAERL-DRFDVQVIDGYDGL---RRFKADPSVLTAFDPRLVIVGLGAGLQEVVASVALDLVPESSV 182
Cdd:TIGR00696  50 PIFLYGGKPDVLQQLKVKLiKEYPKLKIVGAFGPlepEERKAALAKIARSGAGIVFVGLGCPKQEIWMRNHRHLKPDAVM 129

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1421682225 183 CTAGGWIDQFA----RAaddyfPDWVHAARLGWAWRIAHEPKRLTKRYTV 228
Cdd:TIGR00696 130 IGVGGSFDVFSglvkRA-----PRWLMRLGLEWLYRLRMEPWRWKRMLLI 174
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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