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Conserved domains on  [gi|1423688667|ref|WP_112095995|]
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phage repressor protein CI [Haemophilus influenzae]

Protein Classification

phage repressor protein CI( domain architecture ID 10537110)

phage repressor protein CI is a repressor of lysogeny; it contains an XRE family helix-turn-helix (HTH) DNA binding domain and a C-terminal domain belonging to the S24/S26 LexA/signal peptidase superfamily

CATH:  1.10.260.40|2.10.109.10|1.10.10.10
Gene Ontology:  GO:0045892|GO:0003677
PubMed:  2370665|10473770|15808743
SCOP:  4000321|4000362

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Phage_CI_repr pfam07022
Bacteriophage CI repressor helix-turn-helix domain; This family consists of several phage CI ...
 9-73 1.03e-29

Bacteriophage CI repressor helix-turn-helix domain; This family consists of several phage CI repressor proteins and related bacterial sequences. The CI repressor is known to function as a transcriptional switch, determining whether transcription is lytic or lysogenic.


:

Pssm-ID: 311152  Cd Length: 65  Bit Score: 104.33  E-value: 1.03e-29
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1423688667   9 DVISRIMEAYGFANRKLLAEHLGMPHSTFGTWAKRGFFPAELVIRCVKETGARLDYVAYGNEPIF 73
Cdd:pfam07022   1 AVIERLMKAYGFKSRQELADHLGVSKSTLSTWYTRDSFPAELVVRCALETGVSLEWLATGDGELY 65
Peptidase_S24_S26 super family cl10465
The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal ...
 120-185 1.11e-13

The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the repressor of genes in the cellular SOS response to DNA damage; MucA and the related UmuD proteins, which are lesion-bypass DNA polymerases, induced in response to mitogenic DNA damage; RulA, a component of the rulAB locus that confers resistance to UV, and RuvA, which is a component of the RuvABC resolvasome that catalyzes the resolution of Holliday junctions that arise during genetic recombination and DNA repair. The S26 type I signal peptidase (SPase) family also includes mitochondrial inner membrane protease (IMP)-like members. SPases are essential membrane-bound proteases which function to cleave away the amino-terminal signal peptide from the translocated pre-protein, thus playing a crucial role in the transport of proteins across membranes in all living organisms. All members in this superfamily are unique serine proteases that carry out catalysis using a serine/lysine dyad instead of the prototypical serine/histidine/aspartic acid triad found in most serine proteases.


The actual alignment was detected with superfamily member pfam16452:

Pssm-ID: 447902  Cd Length: 101  Bit Score: 63.88  E-value: 1.11e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1423688667 120 IDEDNHTYFATSDYGNLVDGEYFVIVENSHLIRYITVLPAGKIRVDGGKFSFECELSDIDVVGKVI 185
Cdd:pfam16452  36 ILAGNKSFIIDTQFADVSDGRWLVDIEGRLSIRDLTRIPGNRLRVSGGEVPFECGVDDIKALGRVM 101
 
Name Accession Description Interval E-value
Phage_CI_repr pfam07022
Bacteriophage CI repressor helix-turn-helix domain; This family consists of several phage CI ...
 9-73 1.03e-29

Bacteriophage CI repressor helix-turn-helix domain; This family consists of several phage CI repressor proteins and related bacterial sequences. The CI repressor is known to function as a transcriptional switch, determining whether transcription is lytic or lysogenic.


Pssm-ID: 311152  Cd Length: 65  Bit Score: 104.33  E-value: 1.03e-29
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1423688667   9 DVISRIMEAYGFANRKLLAEHLGMPHSTFGTWAKRGFFPAELVIRCVKETGARLDYVAYGNEPIF 73
Cdd:pfam07022   1 AVIERLMKAYGFKSRQELADHLGVSKSTLSTWYTRDSFPAELVVRCALETGVSLEWLATGDGELY 65
Phage_CI_C pfam16452
Bacteriophage CI repressor C-terminal domain; The C-terminal domain of the CI repressor ...
 120-185 1.11e-13

Bacteriophage CI repressor C-terminal domain; The C-terminal domain of the CI repressor functions in oligomer formation.


Pssm-ID: 435345  Cd Length: 101  Bit Score: 63.88  E-value: 1.11e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1423688667 120 IDEDNHTYFATSDYGNLVDGEYFVIVENSHLIRYITVLPAGKIRVDGGKFSFECELSDIDVVGKVI 185
Cdd:pfam16452  36 ILAGNKSFIIDTQFADVSDGRWLVDIEGRLSIRDLTRIPGNRLRVSGGEVPFECGVDDIKALGRVM 101
 
Name Accession Description Interval E-value
Phage_CI_repr pfam07022
Bacteriophage CI repressor helix-turn-helix domain; This family consists of several phage CI ...
 9-73 1.03e-29

Bacteriophage CI repressor helix-turn-helix domain; This family consists of several phage CI repressor proteins and related bacterial sequences. The CI repressor is known to function as a transcriptional switch, determining whether transcription is lytic or lysogenic.


Pssm-ID: 311152  Cd Length: 65  Bit Score: 104.33  E-value: 1.03e-29
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1423688667   9 DVISRIMEAYGFANRKLLAEHLGMPHSTFGTWAKRGFFPAELVIRCVKETGARLDYVAYGNEPIF 73
Cdd:pfam07022   1 AVIERLMKAYGFKSRQELADHLGVSKSTLSTWYTRDSFPAELVVRCALETGVSLEWLATGDGELY 65
Phage_CI_C pfam16452
Bacteriophage CI repressor C-terminal domain; The C-terminal domain of the CI repressor ...
 120-185 1.11e-13

Bacteriophage CI repressor C-terminal domain; The C-terminal domain of the CI repressor functions in oligomer formation.


Pssm-ID: 435345  Cd Length: 101  Bit Score: 63.88  E-value: 1.11e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1423688667 120 IDEDNHTYFATSDYGNLVDGEYFVIVENSHLIRYITVLPAGKIRVDGGKFSFECELSDIDVVGKVI 185
Cdd:pfam16452  36 ILAGNKSFIIDTQFADVSDGRWLVDIEGRLSIRDLTRIPGNRLRVSGGEVPFECGVDDIKALGRVM 101
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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