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Conserved domains on  [gi|1424325668|ref|WP_112593078|]
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universal stress protein [Brucella anthropi]

Protein Classification

universal stress protein( domain architecture ID 10001747)

universal stress protein (USP) enhances the rate of cell survival during prolonged exposure to stress agents

CATH:  3.40.50.620
Gene Ontology:  GO:0042802
PubMed:  23745136|9405142|12732303
SCOP:  8083864

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
UspA COG0589
Nucleotide-binding universal stress protein, UspA family [Signal transduction mechanisms];
162-281 1.71e-17

Nucleotide-binding universal stress protein, UspA family [Signal transduction mechanisms];


:

Pssm-ID: 440354  Cd Length: 136  Bit Score: 76.88  E-value: 1.71e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1424325668 162 PVNKLLIAYDGGTMAMKTVDQVSRspILAGLGCKLV------------MAGEDTPEN-----RKKLDDAAVILKAAGYAP 224
Cdd:COG0589     1 MYKRILVPTDGSEEAERALEYAAE--LAKALGAELHllhvvdpppsaaAGPEELEEElreeaEEALEEAAERLEEAGVEV 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1424325668 225 EVALVQGAADKVITAIIEQEGYDLLAMGAYSHSRLRSLFIGSTTTEMIRSCKVPVVI 281
Cdd:COG0589    79 ETVVREGDPAEAILEAAEELDADLIVMGSRGRSGLRRLLLGSVAERVLRHAPCPVLV 135
UspA COG0589
Nucleotide-binding universal stress protein, UspA family [Signal transduction mechanisms];
1-150 7.46e-17

Nucleotide-binding universal stress protein, UspA family [Signal transduction mechanisms];


:

Pssm-ID: 440354  Cd Length: 136  Bit Score: 75.34  E-value: 7.46e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1424325668   1 MKILGLIDGSTYAESVCDHAAWIAGKIDGTVEILHVIGRRDlstepvnlsgniglgARTALLEELADldaqkakVAQKRA 80
Cdd:COG0589     3 KRILVPTDGSEEAERALEYAAELAKALGAELHLLHVVDPPP---------------SAAAGPEELEE-------ELREEA 60

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1424325668  81 RLLLEGAKERLLAAGVqNVETKLRNGDLVETVLEF--EADTDIIVIGKRGEGAdFAKGHLGSNLERVVRSTH 150
Cdd:COG0589    61 EEALEEAAERLEEAGV-EVETVVREGDPAEAILEAaeELDADLIVMGSRGRSG-LRRLLLGSVAERVLRHAP 130
 
Name Accession Description Interval E-value
UspA COG0589
Nucleotide-binding universal stress protein, UspA family [Signal transduction mechanisms];
162-281 1.71e-17

Nucleotide-binding universal stress protein, UspA family [Signal transduction mechanisms];


Pssm-ID: 440354  Cd Length: 136  Bit Score: 76.88  E-value: 1.71e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1424325668 162 PVNKLLIAYDGGTMAMKTVDQVSRspILAGLGCKLV------------MAGEDTPEN-----RKKLDDAAVILKAAGYAP 224
Cdd:COG0589     1 MYKRILVPTDGSEEAERALEYAAE--LAKALGAELHllhvvdpppsaaAGPEELEEElreeaEEALEEAAERLEEAGVEV 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1424325668 225 EVALVQGAADKVITAIIEQEGYDLLAMGAYSHSRLRSLFIGSTTTEMIRSCKVPVVI 281
Cdd:COG0589    79 ETVVREGDPAEAILEAAEELDADLIVMGSRGRSGLRRLLLGSVAERVLRHAPCPVLV 135
UspA COG0589
Nucleotide-binding universal stress protein, UspA family [Signal transduction mechanisms];
1-150 7.46e-17

Nucleotide-binding universal stress protein, UspA family [Signal transduction mechanisms];


Pssm-ID: 440354  Cd Length: 136  Bit Score: 75.34  E-value: 7.46e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1424325668   1 MKILGLIDGSTYAESVCDHAAWIAGKIDGTVEILHVIGRRDlstepvnlsgniglgARTALLEELADldaqkakVAQKRA 80
Cdd:COG0589     3 KRILVPTDGSEEAERALEYAAELAKALGAELHLLHVVDPPP---------------SAAAGPEELEE-------ELREEA 60

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1424325668  81 RLLLEGAKERLLAAGVqNVETKLRNGDLVETVLEF--EADTDIIVIGKRGEGAdFAKGHLGSNLERVVRSTH 150
Cdd:COG0589    61 EEALEEAAERLEEAGV-EVETVVREGDPAEAILEAaeELDADLIVMGSRGRSG-LRRLLLGSVAERVLRHAP 130
USP-like cd00293
universal stress protein (USP) and similar proteins; The universal stress protein (USP) is a ...
 2-156 1.21e-15

universal stress protein (USP) and similar proteins; The universal stress protein (USP) is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. USP enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae Usp reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, although USP lacks ATP-binding activity.


Pssm-ID: 467483 [Multi-domain]  Cd Length: 135  Bit Score: 71.99  E-value: 1.21e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1424325668   2 KILGLIDGSTYAESVCDHAAWIAGKIDGTVEILHVIGRRDLStepvnlsgniglgartalleELADLDAQKAKVAQKRAR 81
Cdd:cd00293     1 KILVAVDGSEESERALEWALELAKRPGAELTLLHVVDPPPSS--------------------SLSGGLEELADELKEEAE 60

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1424325668  82 LLLEGAKERLLAAGVqNVETKLRNGDLVETVLEF--EADTDIIVIGKRGEGAdFAKGHLGSNLERVVRSTHKAIVIA 156
Cdd:cd00293    61 ELLEEAKKLAEEAGV-EVETIVVEGDPAEAILEEakELGADLIVMGSRGRSG-LKRLLLGSVSEYVLRHAPCPVLVV 135
Usp pfam00582
Universal stress protein family; The universal stress protein UspA is a small cytoplasmic ...
 3-155 2.67e-13

Universal stress protein family; The universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae UspA reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, though UspA lacks ATP-binding activity.


Pssm-ID: 425765 [Multi-domain]  Cd Length: 137  Bit Score: 65.51  E-value: 2.67e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1424325668   3 ILGLIDGSTYAESVCDHAAWIAGKIDGTVEILHVIgrrdlstePVNLSGNIGLGARTALLEELADldaqkakvaqkRARL 82
Cdd:pfam00582   1 ILVAVDGSEESKRALEWAAELAKARGAELILLHVI--------DPPPSGAASLADESAEEEELEL-----------ELAE 61

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1424325668  83 LLEGAKERLLAAGVQNVETKLRNGDLVETVLEF--EADTDIIVIGKRGEGAdFAKGHLGSNLERVVRSTHKAIVI 155
Cdd:pfam00582  62 AEALAAAAAAEAGGVKVEVVVVVGDPAEEILEVaeEEDADLIVMGSRGRSG-LSRLLLGSVAEYVLRHAPCPVLV 135
USP-like cd00293
universal stress protein (USP) and similar proteins; The universal stress protein (USP) is a ...
 165-281 5.85e-12

universal stress protein (USP) and similar proteins; The universal stress protein (USP) is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. USP enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae Usp reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, although USP lacks ATP-binding activity.


Pssm-ID: 467483 [Multi-domain]  Cd Length: 135  Bit Score: 61.98  E-value: 5.85e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1424325668 165 KLLIAYDGGTMAMKTVDQ-----------------VSRSPILAGLGCKLVMAGEDTPENRKKLDDAAVILKAAGYAPEVA 227
Cdd:cd00293     1 KILVAVDGSEESERALEWalelakrpgaeltllhvVDPPPSSSLSGGLEELADELKEEAEELLEEAKKLAEEAGVEVETI 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1424325668 228 LVQGAADKVITAIIEQEGYDLLAMGAYSHSRLRSLFIGSTTTEMIRSCKVPVVI 281
Cdd:cd00293    81 VVEGDPAEAILEEAKELGADLIVMGSRGRSGLKRLLLGSVSEYVLRHAPCPVLV 134
Usp pfam00582
Universal stress protein family; The universal stress protein UspA is a small cytoplasmic ...
 205-283 1.79e-08

Universal stress protein family; The universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae UspA reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, though UspA lacks ATP-binding activity.


Pssm-ID: 425765 [Multi-domain]  Cd Length: 137  Bit Score: 52.02  E-value: 1.79e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1424325668 205 ENRKKLDDAAVILKAAGYAPEVALVQGAADKVITAIIEQEGYDLLAMGAYSHSRLRSLFIGSTTTEMIRSCKVPVVIFR 283
Cdd:pfam00582  59 LAEAEALAAAAAAEAGGVKVEVVVVVGDPAEEILEVAEEEDADLIVMGSRGRSGLSRLLLGSVAEYVLRHAPCPVLVVR 137
 
Name Accession Description Interval E-value
UspA COG0589
Nucleotide-binding universal stress protein, UspA family [Signal transduction mechanisms];
162-281 1.71e-17

Nucleotide-binding universal stress protein, UspA family [Signal transduction mechanisms];


Pssm-ID: 440354  Cd Length: 136  Bit Score: 76.88  E-value: 1.71e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1424325668 162 PVNKLLIAYDGGTMAMKTVDQVSRspILAGLGCKLV------------MAGEDTPEN-----RKKLDDAAVILKAAGYAP 224
Cdd:COG0589     1 MYKRILVPTDGSEEAERALEYAAE--LAKALGAELHllhvvdpppsaaAGPEELEEElreeaEEALEEAAERLEEAGVEV 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1424325668 225 EVALVQGAADKVITAIIEQEGYDLLAMGAYSHSRLRSLFIGSTTTEMIRSCKVPVVI 281
Cdd:COG0589    79 ETVVREGDPAEAILEAAEELDADLIVMGSRGRSGLRRLLLGSVAERVLRHAPCPVLV 135
UspA COG0589
Nucleotide-binding universal stress protein, UspA family [Signal transduction mechanisms];
1-150 7.46e-17

Nucleotide-binding universal stress protein, UspA family [Signal transduction mechanisms];


Pssm-ID: 440354  Cd Length: 136  Bit Score: 75.34  E-value: 7.46e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1424325668   1 MKILGLIDGSTYAESVCDHAAWIAGKIDGTVEILHVIGRRDlstepvnlsgniglgARTALLEELADldaqkakVAQKRA 80
Cdd:COG0589     3 KRILVPTDGSEEAERALEYAAELAKALGAELHLLHVVDPPP---------------SAAAGPEELEE-------ELREEA 60

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1424325668  81 RLLLEGAKERLLAAGVqNVETKLRNGDLVETVLEF--EADTDIIVIGKRGEGAdFAKGHLGSNLERVVRSTH 150
Cdd:COG0589    61 EEALEEAAERLEEAGV-EVETVVREGDPAEAILEAaeELDADLIVMGSRGRSG-LRRLLLGSVAERVLRHAP 130
USP-like cd00293
universal stress protein (USP) and similar proteins; The universal stress protein (USP) is a ...
 2-156 1.21e-15

universal stress protein (USP) and similar proteins; The universal stress protein (USP) is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. USP enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae Usp reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, although USP lacks ATP-binding activity.


Pssm-ID: 467483 [Multi-domain]  Cd Length: 135  Bit Score: 71.99  E-value: 1.21e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1424325668   2 KILGLIDGSTYAESVCDHAAWIAGKIDGTVEILHVIGRRDLStepvnlsgniglgartalleELADLDAQKAKVAQKRAR 81
Cdd:cd00293     1 KILVAVDGSEESERALEWALELAKRPGAELTLLHVVDPPPSS--------------------SLSGGLEELADELKEEAE 60

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1424325668  82 LLLEGAKERLLAAGVqNVETKLRNGDLVETVLEF--EADTDIIVIGKRGEGAdFAKGHLGSNLERVVRSTHKAIVIA 156
Cdd:cd00293    61 ELLEEAKKLAEEAGV-EVETIVVEGDPAEAILEEakELGADLIVMGSRGRSG-LKRLLLGSVSEYVLRHAPCPVLVV 135
Usp pfam00582
Universal stress protein family; The universal stress protein UspA is a small cytoplasmic ...
 3-155 2.67e-13

Universal stress protein family; The universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae UspA reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, though UspA lacks ATP-binding activity.


Pssm-ID: 425765 [Multi-domain]  Cd Length: 137  Bit Score: 65.51  E-value: 2.67e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1424325668   3 ILGLIDGSTYAESVCDHAAWIAGKIDGTVEILHVIgrrdlstePVNLSGNIGLGARTALLEELADldaqkakvaqkRARL 82
Cdd:pfam00582   1 ILVAVDGSEESKRALEWAAELAKARGAELILLHVI--------DPPPSGAASLADESAEEEELEL-----------ELAE 61

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1424325668  83 LLEGAKERLLAAGVQNVETKLRNGDLVETVLEF--EADTDIIVIGKRGEGAdFAKGHLGSNLERVVRSTHKAIVI 155
Cdd:pfam00582  62 AEALAAAAAAEAGGVKVEVVVVVGDPAEEILEVaeEEDADLIVMGSRGRSG-LSRLLLGSVAEYVLRHAPCPVLV 135
USP-like cd00293
universal stress protein (USP) and similar proteins; The universal stress protein (USP) is a ...
 165-281 5.85e-12

universal stress protein (USP) and similar proteins; The universal stress protein (USP) is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. USP enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae Usp reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, although USP lacks ATP-binding activity.


Pssm-ID: 467483 [Multi-domain]  Cd Length: 135  Bit Score: 61.98  E-value: 5.85e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1424325668 165 KLLIAYDGGTMAMKTVDQ-----------------VSRSPILAGLGCKLVMAGEDTPENRKKLDDAAVILKAAGYAPEVA 227
Cdd:cd00293     1 KILVAVDGSEESERALEWalelakrpgaeltllhvVDPPPSSSLSGGLEELADELKEEAEELLEEAKKLAEEAGVEVETI 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1424325668 228 LVQGAADKVITAIIEQEGYDLLAMGAYSHSRLRSLFIGSTTTEMIRSCKVPVVI 281
Cdd:cd00293    81 VVEGDPAEAILEEAKELGADLIVMGSRGRSGLKRLLLGSVSEYVLRHAPCPVLV 134
Usp pfam00582
Universal stress protein family; The universal stress protein UspA is a small cytoplasmic ...
 205-283 1.79e-08

Universal stress protein family; The universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae UspA reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, though UspA lacks ATP-binding activity.


Pssm-ID: 425765 [Multi-domain]  Cd Length: 137  Bit Score: 52.02  E-value: 1.79e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1424325668 205 ENRKKLDDAAVILKAAGYAPEVALVQGAADKVITAIIEQEGYDLLAMGAYSHSRLRSLFIGSTTTEMIRSCKVPVVIFR 283
Cdd:pfam00582  59 LAEAEALAAAAAAEAGGVKVEVVVVVGDPAEEILEVAEEEDADLIVMGSRGRSGLSRLLLGSVAEYVLRHAPCPVLVVR 137
USP_At3g01520-like cd23659
universal stress protein At3g01520 and similar proteins; This subfamily includes plant and ...
 225-283 2.65e-04

universal stress protein At3g01520 and similar proteins; This subfamily includes plant and fungal proteins of unknown function, including Arabidopsis thaliana At3g01520. A. thaliana contains 44 USP domain-containing proteins; the USP domain is found either in a small protein with unknown physiological function or as an N-terminal portion of a multi-domain protein, usually a protein kinase. The gene At3g01520 of Arabidopsis thaliana encodes a 175-residue universal stress protein (USP)-like protein which is widely found in the genomes of bacteria, as well as fungi, protozoa, and plants. The bound AMP and conservation of residues in the ATP-binding loop suggest that the protein At3g01520 belongs to the ATP-binding USP subfamily. Universal stress proteins (USPs) are small cytoplasmic bacterial proteins whose expression is enhanced when the cell is exposed to stress agents. USP enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity.


Pssm-ID: 467505  Cd Length: 143  Bit Score: 40.30  E-value: 2.65e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1424325668 225 EVALVQGAADKVITAIIEQEGYDLLAMGAYSHSRLRSLFIGSTTTEMIRSCKVPVVIFR 283
Cdd:cd23659    85 KVEVVAGDPGEVICKAAEELKADLIVMGSRGLGALKRTLLGSVSDYVVHHSPCPVLVVR 143
USP_At3g01520-like cd23659
universal stress protein At3g01520 and similar proteins; This subfamily includes plant and ...
 1-140 4.19e-04

universal stress protein At3g01520 and similar proteins; This subfamily includes plant and fungal proteins of unknown function, including Arabidopsis thaliana At3g01520. A. thaliana contains 44 USP domain-containing proteins; the USP domain is found either in a small protein with unknown physiological function or as an N-terminal portion of a multi-domain protein, usually a protein kinase. The gene At3g01520 of Arabidopsis thaliana encodes a 175-residue universal stress protein (USP)-like protein which is widely found in the genomes of bacteria, as well as fungi, protozoa, and plants. The bound AMP and conservation of residues in the ATP-binding loop suggest that the protein At3g01520 belongs to the ATP-binding USP subfamily. Universal stress proteins (USPs) are small cytoplasmic bacterial proteins whose expression is enhanced when the cell is exposed to stress agents. USP enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity.


Pssm-ID: 467505  Cd Length: 143  Bit Score: 39.53  E-value: 4.19e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1424325668   1 MKILGLIDGSTYAESVCDHAA-WIAGKIDgTVEILHVIgrrdlstEPVNLSgniglgarTALLEELADLDAQKAKVAQKR 79
Cdd:cd23659     1 RKVLIAVDGSEESEYALEWALeNLHRPGD-EVVLLHVI-------EPPSLP--------AASLGSGSEEWEALEEEAREK 64

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1424325668  80 ARLLLEGAKERLLAAGVQNVETKLRNGD----LVETVLEFEADtdIIVIGKRGEGAdFAKGHLGS 140
Cdd:cd23659    65 AEKLLEKYEKKLKEEKGIKVKVEVVAGDpgevICKAAEELKAD--LIVMGSRGLGA-LKRTLLGS 126
USP-E_repeat2 cd23660
Universal stress protein E, repeat 2; UspE is a tandem-type USP that consists of two USP ...
 228-272 1.08e-03

Universal stress protein E, repeat 2; UspE is a tandem-type USP that consists of two USP domains. The UspE expression levels of Escherichia coli become elevated in response to oxidative stress and DNA damaging agents, including exposure to mitomycin C, cadmium, and hydrogen peroxide. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity.


Pssm-ID: 467506  Cd Length: 148  Bit Score: 38.79  E-value: 1.08e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1424325668 228 LVQGAADKVITAIIEQEGYDLLAMGAYSHSRLRSLFIGSTTTEMI 272
Cdd:cd23660    92 VLEGLPEEVIPDFAEELDADIVVLGTVARTGLSGALIGNTAEHVL 136
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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