|
Name |
Accession |
Description |
Interval |
E-value |
| NrdA |
COG0209 |
Ribonucleotide reductase alpha subunit [Nucleotide transport and metabolism]; Ribonucleotide ... |
60-723 |
1.38e-157 |
|
Ribonucleotide reductase alpha subunit [Nucleotide transport and metabolism]; Ribonucleotide reductase alpha subunit is part of the Pathway/BioSystem: Pyrimidine salvage
Pssm-ID: 439979 [Multi-domain] Cd Length: 665 Bit Score: 477.37 E-value: 1.38e-157
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 60 DIFETEISEEVYGQNYQYGTDDRVP-----DTWYRNARAMAQVEDDTDM--WTQRFYQLLSGkglgtgpFPFTPGGRIFA 132
Cdd:COG0209 46 DRFFSYNALKTLYDRYLLKDEDGKPletpqDLFMRVAMGLAAAEKPEDReeWAKEFYDLLSS-------LRFLPATPTLF 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 133 NAGTGLGkaTLINCFVSGfqghDQDSMDEIQAELTRQAKILASEGGYGFCAHIMRPRGARIGGVGSMTPGAVQMLDVWNk 212
Cdd:COG0209 119 NAGTPRG--QLSSCFVLP----VEDSLESIFDALKDAALLSKSGGGVGFNFSRLRPKGSPIKGTGGVSSGPVPFMKVFD- 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 213 qAATIVAGSGMKsdrddvkdkiRKGAQMVTMGIWHPDIIEFIEAKQ----EPGRLHKFNMSVLITDEFMEAVKNDDTWAL 288
Cdd:COG0209 192 -DAAVAVNQGGK----------RRGANMVYLRVWHPDIEEFLDLKKnngdERRRLHNFNISVWIPDLFMEAVEEDEDWTL 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 289 RFP-DYENEKEFYKQHWDGNLKAYQEKGGTVKTwtdpatgepavYEAREIWNRIMDSTYNRNEPGVIFVDTINKENNLGY 367
Cdd:COG0209 261 FSPrEVPDLYGLYGEEFEEAYEEYEADGRVYKT-----------IKARELWRKILESAWETGEPGILFKDTINRRNPLPH 329
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 368 VEHINATNPCGEQVLP----VGGVCLLGNLNVTQLVDReaGTIDYDLVDDLVPLAVRFLDNVNDLSYVPLEEQQRNLQEK 443
Cdd:COG0209 330 LGVIHSSNLCGEIPLLpyesEDASCNLGSINLAKFVKD--GEFDWEKLEETVRTAVRFLDNVIDINDYPVPEIEKANRRH 407
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 444 RRIGLGHYGDGSALMMMKTRYGSEEGARVMREFQEHLANQAYQASARLAEEKGAFPLFDKDEYLSS--PFVQRLSDKT-- 519
Cdd:COG0209 408 RPIGLGVMGLADALAKLGIPYDSEEARELADEIMEFINYYAYKASAELAKERGAFPAFEGSKYAKGilPFDKYLDDLLip 487
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 520 --------KEMIGDLGLRNSHLLSIQPTGNTSTLGNApSSGIEPVFMHSYIRTSeqpalpdginrppMS------PNAYE 585
Cdd:COG0209 488 ttldwdalREDIKKHGLRNSTLTAIAPTGTISLIAGT-TSGIEPIFSLVYVRKV-------------LDggeftvVNPYL 553
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 586 VgqdidadgTAWTAEEQGDETVLRcqeeghthwQIHPTRDICKDQEVKDYAVRHMETdgTWDPDADWavttrdldvddHL 665
Cdd:COG0209 554 V--------RALKELGLWDEELVE---------KIKEDGSVQDIDELPEELKELYVT--AYEIDPEW-----------HI 603
|
650 660 670 680 690
....*....|....*....|....*....|....*....|....*....|....*....
gi 1425874908 666 TQMKALAPFVDSSMSKTVNVPNDYPFEDFKELYKKAHDTGvIKGVTTYRAGTMS-AVLS 723
Cdd:COG0209 604 DMQAARQKHVDQAISKTLNLPNDATVEDLAELYLLAWKLG-LKGIYYYRDGSRTgQVLS 661
|
|
| NrdJ_Z |
TIGR02504 |
ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; This model represents a ... |
85-722 |
6.96e-153 |
|
ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; This model represents a group of adenosylcobalamin(B12)-dependent ribonucleotide reductases (Class II RNRs) related to the characterized species from Pyrococcus, Thermoplasma, Corynebacterium, and Deinococcus. RNR's are responsible for the conversion of the ribose sugar of RNA into the deoxyribose sugar of DNA. This is the rate-limiting step of DNA biosynthesis. This model identifies genes in a wide range of deeply branching bacteria. All are structurally related to the class I (non-heme iron dependent) RNRs. In most species this gene is known as NrdJ, while in mycobacteria it is called NrdZ. [Purines, pyrimidines, nucleosides, and nucleotides, 2'-Deoxyribonucleotide metabolism]
Pssm-ID: 274168 [Multi-domain] Cd Length: 575 Bit Score: 462.18 E-value: 6.96e-153
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 85 DTWYRNARAMAQVED-----DTDMWTQRFYQLLSGKGlgtgpfpFTPGGRIFANAGtGLGKATLINCFVSGFQghdqDSM 159
Cdd:TIGR02504 21 DLFRRVARALAAAEDkynspVWKQWYERFYDLMVNLG-------FIPNSPTLMNAG-GTRLGQLSACFVLPVE----DSM 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 160 DEIQAELTRQAKILASEGGYGFCAHIMRPRGARIGGVGSMTPGAVQMLDVWNKQAATIVAGSGmksdrddvkdkiRKGAQ 239
Cdd:TIGR02504 89 EDIFEALKEAALIFKRGGGVGYNFSTLRPKGDLVSGTGGVASGPVSFMRVFDSAAGVVKQGGT------------RRGAQ 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 240 MVTMGIWHPDIIEFIEAKQEPGRLHKFNMSVLITDEFMEAVKNDDTWALRFPDyenekefykqhwdgnlkayqekggtvk 319
Cdd:TIGR02504 157 MGILDVWHPDIEEFIEAKAKEGKLQNFNISVGVTDEFMEAVENDEEYELRNPR--------------------------- 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 320 twtdpaTGEPAVYEAREIWNRIMDSTYNRNEPGVIFVDTINKENNLGYVEHINATNPCGEQVLPVGGVCLLGNLNVTQLV 399
Cdd:TIGR02504 210 ------TGEYKEVDARELWDKIVESAWKSAEPGVLFIDTINKWHTCPYGGRINATNPCGEQPLLPYESCNLGSINLAKFV 283
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 400 DREAG---TIDYDLVDDLVPLAVRFLDNVNDLSYVPLEEQQRNLQEKRRIGLGHYGDGSALMMMKTRYGSEEGARVMREF 476
Cdd:TIGR02504 284 KNDFGdeaSFDFERLREVVRLATRFLDNVIDINVFPLPEIAENTKKTRRIGLGIMGLADLLIKLGIPYDSEEARELAEEV 363
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 477 QEHLANQAYQASARLAEEKGAFPLFDKDEYLSSP-----FVQRLSDKTKEMIGDLGLRNSHLLSIQPTGNTSTLGNApSS 551
Cdd:TIGR02504 364 MEFIADAAYRASAELAKERGAFPLYDASKYPMGRamgarIPSALPAEIREAIRKYGIRNAQLTTIAPTGTISLIAGT-SS 442
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 552 GIEPVFMHSYIRTseqpaLPDGinrpPMSPNAYEVGQDIdadgtawtAEEQGDEtvlrcqeeghthwqihptrdickDQE 631
Cdd:TIGR02504 443 GIEPVFALVYFRN-----VTVG----GELLEVNPLVELA--------LRELGYY-----------------------SDE 482
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 632 VKDYAVRHMETDGTWDPDA--DWAVTTRDLDVDDHLTQMKALAPFVDSSMSKTVNVPNDYPFEDFKELYKKAHDTGViKG 709
Cdd:TIGR02504 483 IVKYVDEKGTVEGAPGPEElpKVFVTAMDISPEDHVLMQAAIQPWVDSSISKTINMPSDATVEDVKAVYLEAWKLGL-KG 561
|
650
....*....|...
gi 1425874908 710 VTTYRAGTMSAVL 722
Cdd:TIGR02504 562 ITVYRDGSRSSQV 574
|
|
| RNR_II_dimer |
cd02888 |
Class II ribonucleotide reductase, dimeric form; Ribonucleotide reductase (RNR) catalyzes the ... |
107-716 |
3.16e-141 |
|
Class II ribonucleotide reductase, dimeric form; Ribonucleotide reductase (RNR) catalyzes the reductive synthesis of deoxyribonucleotides from their corresponding ribonucleotides. It provides the precursors necessary for DNA synthesis. RNRs are separated into three classes based on their metallocofactor usage. Class I RNRs, found in eukaryotes, bacteria, and bacteriophage, use a diiron-tyrosyl radical. Class II RNRs, found in bacteria, bacteriophage, algae and archaea, use coenzyme B12 (adenosylcobalamin, AdoCbl). Class III RNRs, found in anaerobic bacteria, bacteriophage, and archaea, use an FeS cluster and S-adenosylmethionine to generate a glycyl radical. Many organisms have more than one class of RNR present in their genomes. All three RNRs have a ten-stranded alpha-beta barrel domain that is structurally similar to the domain of PFL (pyruvate formate lyase). Class II RNRs are found in bacteria that can live under both aerobic and anaerobic conditions. Many, but not all members of this class are found to be homodimers. Adenosylcobalamin interacts directly with an active site cysteine to form the reactive cysteine radical.
Pssm-ID: 153089 [Multi-domain] Cd Length: 464 Bit Score: 427.81 E-value: 3.16e-141
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 107 RFYQLLSGKGlgtgpfpFTPGGRIFANAGTGLgKATLINCFVsgfQGHDQDSMDEIQAELTRQAKILASEGGYGFCAHIM 186
Cdd:cd02888 3 EFFYLLLSQG-------FIPNSPTLMNAGTGE-LGQLSACFV---LPVEDDSIEGIFDALKEAALIFKRGGGVGYNFSRL 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 187 RPRGARIGGVGSMTPGAVQMLDVWNKQAATIVAGSGmksdrddvkdkiRKGAQMVTMGIWHPDIIEFIEAKQEPG---RL 263
Cdd:cd02888 72 RPKGDIVKSTGGVASGPVSFMRVFDAATGVIKQGGT------------RRGANMGVLDVDHPDIEEFIDAKMKEEktvVL 139
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 264 HKFNMSVLITDEFMEAVKNDDTWALRFPDYENEKEFYKqhwdgnlkayqekggTVKtwtdpatgepavyeAREIWNRIMD 343
Cdd:cd02888 140 QNFNISVAVTDAFMEAVENDEPWELRNPREPDTGKVYR---------------TVP--------------ARELWDKIVE 190
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 344 STYNRNEPGVIFVDTINKENNLGYVEHINATNPCGEQVLPVGGVCLLGNLNVTQLVDREAG--TIDYDLVDDLVPLAVRF 421
Cdd:cd02888 191 AAWDSADPGVLFIDTINRWNPLPGLGRINATNPCGEQPLLPYESCNLGSINLSKFVKNPFGgaSFDFERLREAVRLAVRF 270
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 422 LDNVNDLSYVPLEEQQRNLQEKRRIGLGHYGDGSALMMMKTRYGSEEGARVMREFQEHLANQAYQASARLAEEKGAFPLF 501
Cdd:cd02888 271 LDNVIDVNRYPLPEIAEETKATRRIGLGVMGLADMLIKLGIPYDSEEARELAERIMSFIRDAAYRASAELAKERGPFPLF 350
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 502 DKDEYLSSPFV---QRLSDKTKEMIGDLGLRNSHLLSIQPTGNTSTLGNApSSGIEPVFmhsyirtseqpalpdginrpp 578
Cdd:cd02888 351 DASRYLMLKVIvnaKELPDDVLEEIEKYGIRNAHLTTIAPTGTISLIAGT-SSGIEPIF--------------------- 408
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 579 mspnayevgqdidadgtawtaeeqgdetvlrcqeeghthwqihptrdickdqevkdyavrhmetdgtwdpdadwavttrd 658
Cdd:cd02888 --------------------------------------------------------------------------------
|
570 580 590 600 610
....*....|....*....|....*....|....*....|....*....|....*...
gi 1425874908 659 lDVDDHLTQMKALAPFVDSSMSKTVNVPNDYPFEDFKELYKKAHDTGViKGVTTYRAG 716
Cdd:cd02888 409 -SPEDHVRMQAALQPWVDGAISKTINLPNDATVEDVEAVYLLAWKLGL-KGITVYRDG 464
|
|
| Ribonuc_red_lgC |
pfam02867 |
Ribonucleotide reductase, barrel domain; |
148-713 |
3.49e-117 |
|
Ribonucleotide reductase, barrel domain;
Pssm-ID: 460729 [Multi-domain] Cd Length: 487 Bit Score: 366.15 E-value: 3.49e-117
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 148 VSGFQGHDQDSMDEIQAELTRQAKILASEGGYGFCAHIMRPRGARIGGVGSMTPGAVQMLDVWNKQAATIVAGSGmksdr 227
Cdd:pfam02867 1 SSCFLLSVEDSLDSIYDTLKEAALLSKGGGGIGLNLSKLRAKGSPIRGTGGASSGVVPFLKLFDDSARYVNQGGK----- 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 228 ddvkdkiRKGAQMVTMGIWHPDIIEFIEAKQ----EPGRLHKFNMSVLITDEFMEAVKNDDTWALRFPDY-ENEKEFYKQ 302
Cdd:pfam02867 76 -------RRGAAAVYLEVWHPDIEEFLDLKKnngdEEVRARNLNLGVWVPDLFMERVEADEDWTLFSPREaPDLEDLYGE 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 303 HWDGNLKAYQEKGGTVKTWTDpatgepavyeAREIWNRIMDSTYNRNEPGVIFVDTINKENNLGYVEHINATNPCGEQVL 382
Cdd:pfam02867 149 EFEKEYYEREENEGIRKKTVK----------ARELWFKIAKSQIETGYPYILFKDAVNRKNPQKHLGTIKSSNLCTEIVQ 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 383 P----VGGVCLLGNLNVTQLVDREaGTIDYDLVDDLVPLAVRFLDNVNDLSYVPLEEQQRNLQEKRRIGLGHYGDGSALM 458
Cdd:pfam02867 219 PtspsEIAVCNLASINLAKFVEFG-GTFDFEKLREVVKLAVRALDNVIDINDYPVPEARRSNKRHRPIGLGVMGLADALA 297
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 459 MMKTRYGSEEGARVMREFQEHLANQAYQASARLAEEKGAFPLFDK----------DEYLSSPFVQRLS------DKTKEM 522
Cdd:pfam02867 298 KLGIPYDSEEARDLNDKIFETMYYYALKASSELAKEKGPFPGFEGskyskgilqfDKYVKTDFAPKASktredwEELRED 377
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 523 IGDLGLRNSHLLSIQPTGNTSTLGNApSSGIEPVFMHSYIRTSeqpalpdginrppmspnayevgqdidadgtawtaeeq 602
Cdd:pfam02867 378 IKKYGLRNSQLTAIAPTGSISQIAGA-TESIEPIFSNVYSRKV------------------------------------- 419
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 603 gdetvlrcqeeghthwqihptrdicKDQEVKDYavrhmetdgtwdpdadwAVTTRDLDVDDHLTQMKALAPFVDSSMSKT 682
Cdd:pfam02867 420 -------------------------LSEETKEY-----------------YKTAYDIDQKAHIDMAAARQPFVDQSISKT 457
|
570 580 590
....*....|....*....|....*....|.
gi 1425874908 683 VNVPNDYPFEDFKELYKKAHDTGvIKGVTTY 713
Cdd:pfam02867 458 LFLPNDATTSDLKSLYLYAWKLG-LKTIYYY 487
|
|
| PRK08665 |
PRK08665 |
vitamin B12-dependent ribonucleotide reductase; |
89-908 |
9.55e-105 |
|
vitamin B12-dependent ribonucleotide reductase;
Pssm-ID: 236330 [Multi-domain] Cd Length: 752 Bit Score: 341.91 E-value: 9.55e-105
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 89 RNARAMAQVE------DDTDMWTQRFYQLLSGkglgtgpFPFTPGGRIFANAGTGLGKatLINCFVSGFQghdqDSMDEI 162
Cdd:PRK08665 43 RVARTIAAAEliydskADVEALADRFYDLMTS-------LEFLPNSPTLMNAGRELGQ--LSACFVLPVG----DSIEEI 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 163 QAELTRQAKILASEGGYGFCAHIMRPRGARIGGVGSMTPGAVQMLDVWNkqAATivagsgmksdrDDVKDK-IRKGAQMV 241
Cdd:PRK08665 110 FDAVKHAALIHKSGGGTGFSFSRLRPKNDRVGSTGGVASGPVSFMRVFD--AAT-----------EAIKQGgTRRGANMG 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 242 TMGIWHPDIIEFIEAKQEPGRLHKFNMSVLITDEFMEAVKNDDtwalrfpDYEnekefykqhwdgnlkayqekggtvktW 321
Cdd:PRK08665 177 ILRVDHPDIMEFITCKEDNGELTNFNISVAITEAFMEAVEADE-------EYD--------------------------L 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 322 TDPATGEPA-VYEAREIWNRIMDSTYNRNEPGVIFVDTINKENNLGYVEHINATNPCGEQVLPVGGVCLLGNLNVTQLVd 400
Cdd:PRK08665 224 INPRTGEVVgRLNAREVFDLIVEMAWENGEPGIVFIDRINRDNPTPHLGEIESTNPCGEQPLLPYESCNLGSINLSKMV- 302
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 401 rEAGTIDYDLVDDLVPLAVRFLDNVNDLSYVPLEEQQRNLQEKRRIGLGHYGDGSALMMMKTRYGSEE----GARVMREF 476
Cdd:PRK08665 303 -KNGDVDWEKLREVVHLAVRFLDNVIDANKYPLPQIEEMTKGNRKIGLGVMGWADMLIQLGIPYDSEEavelAEKVMKFI 381
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 477 QEhlanQAYQASARLAEEKGAFPLFDKdeylsSPFVQRlsdktkemiGDLGLRNSHLLSIQPTGNTSTLGNApSSGIEPV 556
Cdd:PRK08665 382 QD----EAHAASRELAEERGPFPNYEG-----SIYDKD---------GLGPMRNATVTTIAPTGTISIIAGC-SSGIEPL 442
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 557 FMHSYIRTseqpaLPDGiNRPPmspnayEVGQDIDAdgtawTAEEQG---DETVLRCQEEGHthwqihptrdickdqevk 633
Cdd:PRK08665 443 FALSFTRN-----VMDG-ERLV------EVNPVFEA-----AAKEEGfysEELMEKIAEKGS------------------ 487
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 634 dyaVRHMEtdgtwDPDADWA---VTTRDLDVDDHLTQMKALAPFVDSSMSKTVNVPNDYPFEDFKELYKKAHDTGViKGV 710
Cdd:PRK08665 488 ---IQDID-----EVPEDVRrvfVTAHDISPEWHVRMQAAFQKHTDNAVSKTVNFPNEATIEDVREVYRLAYELGC-KGV 558
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 711 TTYRAGTMSA-VLSGEDDGDDDRTVPRTEAP------DRPETLPCAIHRVRYQGDHWTILVGFLEDHPYEVFAfksegea 783
Cdd:PRK08665 559 TIYRDGSRDEqVLSTGKKEKKEEEPAAAVEPkkleprPRPKVTKGFTEKVQTGCGPLYVTVNEDEGGPFEVFT------- 631
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 784 plfgddservdegyirknesrhysLLGPNGtvviGDITShmpsdDVRVETRLVSTALRHGSKIDFLVEQLEKAEG-SIAS 862
Cdd:PRK08665 632 ------------------------TLGKAG----GCAAA-----QSEAIGRLVSLALRSGVDVREIVKQLKGIRCpSPAG 678
|
810 820 830 840 850 860 870
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1425874908 863 FGQSM--------AKALRAH--------------------ATDHEV-TCDKCGSAnVRHVEGCMECADCGHSRCS 908
Cdd:PRK08665 679 QGGNKvlscpdaiAKVLEKHylgggkdvgagngtgsagieAPAPERgACPECGSI-LEHEEGCVVCHSCGYSKCG 752
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| NrdA |
COG0209 |
Ribonucleotide reductase alpha subunit [Nucleotide transport and metabolism]; Ribonucleotide ... |
60-723 |
1.38e-157 |
|
Ribonucleotide reductase alpha subunit [Nucleotide transport and metabolism]; Ribonucleotide reductase alpha subunit is part of the Pathway/BioSystem: Pyrimidine salvage
Pssm-ID: 439979 [Multi-domain] Cd Length: 665 Bit Score: 477.37 E-value: 1.38e-157
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 60 DIFETEISEEVYGQNYQYGTDDRVP-----DTWYRNARAMAQVEDDTDM--WTQRFYQLLSGkglgtgpFPFTPGGRIFA 132
Cdd:COG0209 46 DRFFSYNALKTLYDRYLLKDEDGKPletpqDLFMRVAMGLAAAEKPEDReeWAKEFYDLLSS-------LRFLPATPTLF 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 133 NAGTGLGkaTLINCFVSGfqghDQDSMDEIQAELTRQAKILASEGGYGFCAHIMRPRGARIGGVGSMTPGAVQMLDVWNk 212
Cdd:COG0209 119 NAGTPRG--QLSSCFVLP----VEDSLESIFDALKDAALLSKSGGGVGFNFSRLRPKGSPIKGTGGVSSGPVPFMKVFD- 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 213 qAATIVAGSGMKsdrddvkdkiRKGAQMVTMGIWHPDIIEFIEAKQ----EPGRLHKFNMSVLITDEFMEAVKNDDTWAL 288
Cdd:COG0209 192 -DAAVAVNQGGK----------RRGANMVYLRVWHPDIEEFLDLKKnngdERRRLHNFNISVWIPDLFMEAVEEDEDWTL 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 289 RFP-DYENEKEFYKQHWDGNLKAYQEKGGTVKTwtdpatgepavYEAREIWNRIMDSTYNRNEPGVIFVDTINKENNLGY 367
Cdd:COG0209 261 FSPrEVPDLYGLYGEEFEEAYEEYEADGRVYKT-----------IKARELWRKILESAWETGEPGILFKDTINRRNPLPH 329
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 368 VEHINATNPCGEQVLP----VGGVCLLGNLNVTQLVDReaGTIDYDLVDDLVPLAVRFLDNVNDLSYVPLEEQQRNLQEK 443
Cdd:COG0209 330 LGVIHSSNLCGEIPLLpyesEDASCNLGSINLAKFVKD--GEFDWEKLEETVRTAVRFLDNVIDINDYPVPEIEKANRRH 407
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 444 RRIGLGHYGDGSALMMMKTRYGSEEGARVMREFQEHLANQAYQASARLAEEKGAFPLFDKDEYLSS--PFVQRLSDKT-- 519
Cdd:COG0209 408 RPIGLGVMGLADALAKLGIPYDSEEARELADEIMEFINYYAYKASAELAKERGAFPAFEGSKYAKGilPFDKYLDDLLip 487
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 520 --------KEMIGDLGLRNSHLLSIQPTGNTSTLGNApSSGIEPVFMHSYIRTSeqpalpdginrppMS------PNAYE 585
Cdd:COG0209 488 ttldwdalREDIKKHGLRNSTLTAIAPTGTISLIAGT-TSGIEPIFSLVYVRKV-------------LDggeftvVNPYL 553
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 586 VgqdidadgTAWTAEEQGDETVLRcqeeghthwQIHPTRDICKDQEVKDYAVRHMETdgTWDPDADWavttrdldvddHL 665
Cdd:COG0209 554 V--------RALKELGLWDEELVE---------KIKEDGSVQDIDELPEELKELYVT--AYEIDPEW-----------HI 603
|
650 660 670 680 690
....*....|....*....|....*....|....*....|....*....|....*....
gi 1425874908 666 TQMKALAPFVDSSMSKTVNVPNDYPFEDFKELYKKAHDTGvIKGVTTYRAGTMS-AVLS 723
Cdd:COG0209 604 DMQAARQKHVDQAISKTLNLPNDATVEDLAELYLLAWKLG-LKGIYYYRDGSRTgQVLS 661
|
|
| NrdJ_Z |
TIGR02504 |
ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; This model represents a ... |
85-722 |
6.96e-153 |
|
ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; This model represents a group of adenosylcobalamin(B12)-dependent ribonucleotide reductases (Class II RNRs) related to the characterized species from Pyrococcus, Thermoplasma, Corynebacterium, and Deinococcus. RNR's are responsible for the conversion of the ribose sugar of RNA into the deoxyribose sugar of DNA. This is the rate-limiting step of DNA biosynthesis. This model identifies genes in a wide range of deeply branching bacteria. All are structurally related to the class I (non-heme iron dependent) RNRs. In most species this gene is known as NrdJ, while in mycobacteria it is called NrdZ. [Purines, pyrimidines, nucleosides, and nucleotides, 2'-Deoxyribonucleotide metabolism]
Pssm-ID: 274168 [Multi-domain] Cd Length: 575 Bit Score: 462.18 E-value: 6.96e-153
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 85 DTWYRNARAMAQVED-----DTDMWTQRFYQLLSGKGlgtgpfpFTPGGRIFANAGtGLGKATLINCFVSGFQghdqDSM 159
Cdd:TIGR02504 21 DLFRRVARALAAAEDkynspVWKQWYERFYDLMVNLG-------FIPNSPTLMNAG-GTRLGQLSACFVLPVE----DSM 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 160 DEIQAELTRQAKILASEGGYGFCAHIMRPRGARIGGVGSMTPGAVQMLDVWNKQAATIVAGSGmksdrddvkdkiRKGAQ 239
Cdd:TIGR02504 89 EDIFEALKEAALIFKRGGGVGYNFSTLRPKGDLVSGTGGVASGPVSFMRVFDSAAGVVKQGGT------------RRGAQ 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 240 MVTMGIWHPDIIEFIEAKQEPGRLHKFNMSVLITDEFMEAVKNDDTWALRFPDyenekefykqhwdgnlkayqekggtvk 319
Cdd:TIGR02504 157 MGILDVWHPDIEEFIEAKAKEGKLQNFNISVGVTDEFMEAVENDEEYELRNPR--------------------------- 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 320 twtdpaTGEPAVYEAREIWNRIMDSTYNRNEPGVIFVDTINKENNLGYVEHINATNPCGEQVLPVGGVCLLGNLNVTQLV 399
Cdd:TIGR02504 210 ------TGEYKEVDARELWDKIVESAWKSAEPGVLFIDTINKWHTCPYGGRINATNPCGEQPLLPYESCNLGSINLAKFV 283
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 400 DREAG---TIDYDLVDDLVPLAVRFLDNVNDLSYVPLEEQQRNLQEKRRIGLGHYGDGSALMMMKTRYGSEEGARVMREF 476
Cdd:TIGR02504 284 KNDFGdeaSFDFERLREVVRLATRFLDNVIDINVFPLPEIAENTKKTRRIGLGIMGLADLLIKLGIPYDSEEARELAEEV 363
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 477 QEHLANQAYQASARLAEEKGAFPLFDKDEYLSSP-----FVQRLSDKTKEMIGDLGLRNSHLLSIQPTGNTSTLGNApSS 551
Cdd:TIGR02504 364 MEFIADAAYRASAELAKERGAFPLYDASKYPMGRamgarIPSALPAEIREAIRKYGIRNAQLTTIAPTGTISLIAGT-SS 442
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 552 GIEPVFMHSYIRTseqpaLPDGinrpPMSPNAYEVGQDIdadgtawtAEEQGDEtvlrcqeeghthwqihptrdickDQE 631
Cdd:TIGR02504 443 GIEPVFALVYFRN-----VTVG----GELLEVNPLVELA--------LRELGYY-----------------------SDE 482
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 632 VKDYAVRHMETDGTWDPDA--DWAVTTRDLDVDDHLTQMKALAPFVDSSMSKTVNVPNDYPFEDFKELYKKAHDTGViKG 709
Cdd:TIGR02504 483 IVKYVDEKGTVEGAPGPEElpKVFVTAMDISPEDHVLMQAAIQPWVDSSISKTINMPSDATVEDVKAVYLEAWKLGL-KG 561
|
650
....*....|...
gi 1425874908 710 VTTYRAGTMSAVL 722
Cdd:TIGR02504 562 ITVYRDGSRSSQV 574
|
|
| RNR_II_dimer |
cd02888 |
Class II ribonucleotide reductase, dimeric form; Ribonucleotide reductase (RNR) catalyzes the ... |
107-716 |
3.16e-141 |
|
Class II ribonucleotide reductase, dimeric form; Ribonucleotide reductase (RNR) catalyzes the reductive synthesis of deoxyribonucleotides from their corresponding ribonucleotides. It provides the precursors necessary for DNA synthesis. RNRs are separated into three classes based on their metallocofactor usage. Class I RNRs, found in eukaryotes, bacteria, and bacteriophage, use a diiron-tyrosyl radical. Class II RNRs, found in bacteria, bacteriophage, algae and archaea, use coenzyme B12 (adenosylcobalamin, AdoCbl). Class III RNRs, found in anaerobic bacteria, bacteriophage, and archaea, use an FeS cluster and S-adenosylmethionine to generate a glycyl radical. Many organisms have more than one class of RNR present in their genomes. All three RNRs have a ten-stranded alpha-beta barrel domain that is structurally similar to the domain of PFL (pyruvate formate lyase). Class II RNRs are found in bacteria that can live under both aerobic and anaerobic conditions. Many, but not all members of this class are found to be homodimers. Adenosylcobalamin interacts directly with an active site cysteine to form the reactive cysteine radical.
Pssm-ID: 153089 [Multi-domain] Cd Length: 464 Bit Score: 427.81 E-value: 3.16e-141
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 107 RFYQLLSGKGlgtgpfpFTPGGRIFANAGTGLgKATLINCFVsgfQGHDQDSMDEIQAELTRQAKILASEGGYGFCAHIM 186
Cdd:cd02888 3 EFFYLLLSQG-------FIPNSPTLMNAGTGE-LGQLSACFV---LPVEDDSIEGIFDALKEAALIFKRGGGVGYNFSRL 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 187 RPRGARIGGVGSMTPGAVQMLDVWNKQAATIVAGSGmksdrddvkdkiRKGAQMVTMGIWHPDIIEFIEAKQEPG---RL 263
Cdd:cd02888 72 RPKGDIVKSTGGVASGPVSFMRVFDAATGVIKQGGT------------RRGANMGVLDVDHPDIEEFIDAKMKEEktvVL 139
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 264 HKFNMSVLITDEFMEAVKNDDTWALRFPDYENEKEFYKqhwdgnlkayqekggTVKtwtdpatgepavyeAREIWNRIMD 343
Cdd:cd02888 140 QNFNISVAVTDAFMEAVENDEPWELRNPREPDTGKVYR---------------TVP--------------ARELWDKIVE 190
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 344 STYNRNEPGVIFVDTINKENNLGYVEHINATNPCGEQVLPVGGVCLLGNLNVTQLVDREAG--TIDYDLVDDLVPLAVRF 421
Cdd:cd02888 191 AAWDSADPGVLFIDTINRWNPLPGLGRINATNPCGEQPLLPYESCNLGSINLSKFVKNPFGgaSFDFERLREAVRLAVRF 270
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 422 LDNVNDLSYVPLEEQQRNLQEKRRIGLGHYGDGSALMMMKTRYGSEEGARVMREFQEHLANQAYQASARLAEEKGAFPLF 501
Cdd:cd02888 271 LDNVIDVNRYPLPEIAEETKATRRIGLGVMGLADMLIKLGIPYDSEEARELAERIMSFIRDAAYRASAELAKERGPFPLF 350
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 502 DKDEYLSSPFV---QRLSDKTKEMIGDLGLRNSHLLSIQPTGNTSTLGNApSSGIEPVFmhsyirtseqpalpdginrpp 578
Cdd:cd02888 351 DASRYLMLKVIvnaKELPDDVLEEIEKYGIRNAHLTTIAPTGTISLIAGT-SSGIEPIF--------------------- 408
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 579 mspnayevgqdidadgtawtaeeqgdetvlrcqeeghthwqihptrdickdqevkdyavrhmetdgtwdpdadwavttrd 658
Cdd:cd02888 --------------------------------------------------------------------------------
|
570 580 590 600 610
....*....|....*....|....*....|....*....|....*....|....*...
gi 1425874908 659 lDVDDHLTQMKALAPFVDSSMSKTVNVPNDYPFEDFKELYKKAHDTGViKGVTTYRAG 716
Cdd:cd02888 409 -SPEDHVRMQAALQPWVDGAISKTINLPNDATVEDVEAVYLLAWKLGL-KGITVYRDG 464
|
|
| Ribonuc_red_lgC |
pfam02867 |
Ribonucleotide reductase, barrel domain; |
148-713 |
3.49e-117 |
|
Ribonucleotide reductase, barrel domain;
Pssm-ID: 460729 [Multi-domain] Cd Length: 487 Bit Score: 366.15 E-value: 3.49e-117
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 148 VSGFQGHDQDSMDEIQAELTRQAKILASEGGYGFCAHIMRPRGARIGGVGSMTPGAVQMLDVWNKQAATIVAGSGmksdr 227
Cdd:pfam02867 1 SSCFLLSVEDSLDSIYDTLKEAALLSKGGGGIGLNLSKLRAKGSPIRGTGGASSGVVPFLKLFDDSARYVNQGGK----- 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 228 ddvkdkiRKGAQMVTMGIWHPDIIEFIEAKQ----EPGRLHKFNMSVLITDEFMEAVKNDDTWALRFPDY-ENEKEFYKQ 302
Cdd:pfam02867 76 -------RRGAAAVYLEVWHPDIEEFLDLKKnngdEEVRARNLNLGVWVPDLFMERVEADEDWTLFSPREaPDLEDLYGE 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 303 HWDGNLKAYQEKGGTVKTWTDpatgepavyeAREIWNRIMDSTYNRNEPGVIFVDTINKENNLGYVEHINATNPCGEQVL 382
Cdd:pfam02867 149 EFEKEYYEREENEGIRKKTVK----------ARELWFKIAKSQIETGYPYILFKDAVNRKNPQKHLGTIKSSNLCTEIVQ 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 383 P----VGGVCLLGNLNVTQLVDREaGTIDYDLVDDLVPLAVRFLDNVNDLSYVPLEEQQRNLQEKRRIGLGHYGDGSALM 458
Cdd:pfam02867 219 PtspsEIAVCNLASINLAKFVEFG-GTFDFEKLREVVKLAVRALDNVIDINDYPVPEARRSNKRHRPIGLGVMGLADALA 297
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 459 MMKTRYGSEEGARVMREFQEHLANQAYQASARLAEEKGAFPLFDK----------DEYLSSPFVQRLS------DKTKEM 522
Cdd:pfam02867 298 KLGIPYDSEEARDLNDKIFETMYYYALKASSELAKEKGPFPGFEGskyskgilqfDKYVKTDFAPKASktredwEELRED 377
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 523 IGDLGLRNSHLLSIQPTGNTSTLGNApSSGIEPVFMHSYIRTSeqpalpdginrppmspnayevgqdidadgtawtaeeq 602
Cdd:pfam02867 378 IKKYGLRNSQLTAIAPTGSISQIAGA-TESIEPIFSNVYSRKV------------------------------------- 419
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 603 gdetvlrcqeeghthwqihptrdicKDQEVKDYavrhmetdgtwdpdadwAVTTRDLDVDDHLTQMKALAPFVDSSMSKT 682
Cdd:pfam02867 420 -------------------------LSEETKEY-----------------YKTAYDIDQKAHIDMAAARQPFVDQSISKT 457
|
570 580 590
....*....|....*....|....*....|.
gi 1425874908 683 VNVPNDYPFEDFKELYKKAHDTGvIKGVTTY 713
Cdd:pfam02867 458 LFLPNDATTSDLKSLYLYAWKLG-LKTIYYY 487
|
|
| PRK08665 |
PRK08665 |
vitamin B12-dependent ribonucleotide reductase; |
89-908 |
9.55e-105 |
|
vitamin B12-dependent ribonucleotide reductase;
Pssm-ID: 236330 [Multi-domain] Cd Length: 752 Bit Score: 341.91 E-value: 9.55e-105
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 89 RNARAMAQVE------DDTDMWTQRFYQLLSGkglgtgpFPFTPGGRIFANAGTGLGKatLINCFVSGFQghdqDSMDEI 162
Cdd:PRK08665 43 RVARTIAAAEliydskADVEALADRFYDLMTS-------LEFLPNSPTLMNAGRELGQ--LSACFVLPVG----DSIEEI 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 163 QAELTRQAKILASEGGYGFCAHIMRPRGARIGGVGSMTPGAVQMLDVWNkqAATivagsgmksdrDDVKDK-IRKGAQMV 241
Cdd:PRK08665 110 FDAVKHAALIHKSGGGTGFSFSRLRPKNDRVGSTGGVASGPVSFMRVFD--AAT-----------EAIKQGgTRRGANMG 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 242 TMGIWHPDIIEFIEAKQEPGRLHKFNMSVLITDEFMEAVKNDDtwalrfpDYEnekefykqhwdgnlkayqekggtvktW 321
Cdd:PRK08665 177 ILRVDHPDIMEFITCKEDNGELTNFNISVAITEAFMEAVEADE-------EYD--------------------------L 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 322 TDPATGEPA-VYEAREIWNRIMDSTYNRNEPGVIFVDTINKENNLGYVEHINATNPCGEQVLPVGGVCLLGNLNVTQLVd 400
Cdd:PRK08665 224 INPRTGEVVgRLNAREVFDLIVEMAWENGEPGIVFIDRINRDNPTPHLGEIESTNPCGEQPLLPYESCNLGSINLSKMV- 302
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 401 rEAGTIDYDLVDDLVPLAVRFLDNVNDLSYVPLEEQQRNLQEKRRIGLGHYGDGSALMMMKTRYGSEE----GARVMREF 476
Cdd:PRK08665 303 -KNGDVDWEKLREVVHLAVRFLDNVIDANKYPLPQIEEMTKGNRKIGLGVMGWADMLIQLGIPYDSEEavelAEKVMKFI 381
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 477 QEhlanQAYQASARLAEEKGAFPLFDKdeylsSPFVQRlsdktkemiGDLGLRNSHLLSIQPTGNTSTLGNApSSGIEPV 556
Cdd:PRK08665 382 QD----EAHAASRELAEERGPFPNYEG-----SIYDKD---------GLGPMRNATVTTIAPTGTISIIAGC-SSGIEPL 442
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 557 FMHSYIRTseqpaLPDGiNRPPmspnayEVGQDIDAdgtawTAEEQG---DETVLRCQEEGHthwqihptrdickdqevk 633
Cdd:PRK08665 443 FALSFTRN-----VMDG-ERLV------EVNPVFEA-----AAKEEGfysEELMEKIAEKGS------------------ 487
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 634 dyaVRHMEtdgtwDPDADWA---VTTRDLDVDDHLTQMKALAPFVDSSMSKTVNVPNDYPFEDFKELYKKAHDTGViKGV 710
Cdd:PRK08665 488 ---IQDID-----EVPEDVRrvfVTAHDISPEWHVRMQAAFQKHTDNAVSKTVNFPNEATIEDVREVYRLAYELGC-KGV 558
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 711 TTYRAGTMSA-VLSGEDDGDDDRTVPRTEAP------DRPETLPCAIHRVRYQGDHWTILVGFLEDHPYEVFAfksegea 783
Cdd:PRK08665 559 TIYRDGSRDEqVLSTGKKEKKEEEPAAAVEPkkleprPRPKVTKGFTEKVQTGCGPLYVTVNEDEGGPFEVFT------- 631
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 784 plfgddservdegyirknesrhysLLGPNGtvviGDITShmpsdDVRVETRLVSTALRHGSKIDFLVEQLEKAEG-SIAS 862
Cdd:PRK08665 632 ------------------------TLGKAG----GCAAA-----QSEAIGRLVSLALRSGVDVREIVKQLKGIRCpSPAG 678
|
810 820 830 840 850 860 870
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1425874908 863 FGQSM--------AKALRAH--------------------ATDHEV-TCDKCGSAnVRHVEGCMECADCGHSRCS 908
Cdd:PRK08665 679 QGGNKvlscpdaiAKVLEKHylgggkdvgagngtgsagieAPAPERgACPECGSI-LEHEEGCVVCHSCGYSKCG 752
|
|
| PRK08115 |
PRK08115 |
vitamin B12-dependent ribonucleotide reductase; |
89-745 |
3.94e-96 |
|
vitamin B12-dependent ribonucleotide reductase;
Pssm-ID: 236152 [Multi-domain] Cd Length: 858 Bit Score: 321.41 E-value: 3.94e-96
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 89 RNARAMAQVEDDTDM---WTQRFYQLLSGKGlgtgpfpFTPGGRIFANAGTGlGKATLINCFVSGFQghdQDSMDEIQAE 165
Cdd:PRK08115 137 RNATGLAAVEKTEEKrkeSFEKFYQELVNMN-------FVPAGRVLYGAGSK-TDVTYFNCYVMPFV---KDSREGISEH 205
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 166 LTRQAKILASEGGYGFCAHIMRPRGARIGGVGSMTPGAVQMLDVWNKQAATIVAGSGmksdrddvkdkiRKGAQMVTMGI 245
Cdd:PRK08115 206 RKQVMEIMSRGGGVGTNGSTLRPRNTLARGVNGKSSGSVSWLDDIAKLTHLVEQGGS------------RRGAQMIMLAD 273
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 246 WHPDIIEFIEAKQEPGRLHKF----------------------------------------------------------- 266
Cdd:PRK08115 274 WHPDILEFIISKMQNPRILRYllentedeqikrlvkeklkftplseveeamyqaivnykniegqggfdtkvikeaenklr 353
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 267 ----------------NMSVLITDEFMEAVKNDDTWALRFPDYEN----EKEFYKQHWD--GNLKAYQEKGGTVKTWTdp 324
Cdd:PRK08115 354 tggtytvnnpefltgaNISVCLTKEFMEAVENDEEYELRFPDVENyteeEMEIYNEEWHevGDVREWEKMGYPVRTYR-- 431
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 325 atgepaVYEAREIWNRI-MDSTYNRnEPGVIFVDTINKENNL-GYVEHINATNPCGEQVLPVGGVCLLGNLNVTQLVDRE 402
Cdd:PRK08115 432 ------KIKAKELWNLInICATYSA-EPGIFFIDNANEMTNAkAYGQKVVATNPCGEQPLAPYSVCNLAAINLANMADKE 504
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 403 AGTIDYDLVDDLVPLAVRFLDNVNDLSYVPLEEQQRNLQEKRRIGLGHYGDGSALMMMKTRYGSEEGARVMREFQEHLAN 482
Cdd:PRK08115 505 TKTVDYEKLKRTVEVGVRMQDNVIDATPYFLEENKKQALGERRVGLGVMGLHDLLIYCETVYGSEEGNQLVDQIFETIAT 584
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 483 QAYQASARLAEEKGAFPLFD----------KDEYLSSPFVQRLSDKTKEMIGDLGLRNSHLLSIQPTGNTSTLGNApSSG 552
Cdd:PRK08115 585 TAYRTSIELAKEKGSFPFLVgqteeetaklREAFINTGYMKKMPEDIREDILKYGIRNSHLLTVAPTGSTGTMVGV-STG 663
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 553 IEPVFMHSYIRTSEqpaLPDGInrppmspnayEVGQDIdadgtawtaeeqgdetvlrcqeeghthwqihptrdickdqeV 632
Cdd:PRK08115 664 LEPYFSFSYYRSGR---LGKFI----------EVKADI-----------------------------------------V 689
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 633 KDYAVRHMETDGTWDPdaDWAVTTRDLDVDDHLTQMKALAPFVDSSMSKTVNVPNDYPFEDFKELYKKAHDTGViKGVTT 712
Cdd:PRK08115 690 QEYLDKHPEADENHLP--EWFISAMELKPEAHADVQCIIQRWVDSSLSKTVNAPKGYTVEQVQKVYERLYRGGA-KGGTV 766
|
730 740 750
....*....|....*....|....*....|....*.
gi 1425874908 713 YRAGTMSA---VLSGEDDGDDDRTVPRTEAPDRPET 745
Cdd:PRK08115 767 YVDGSRDAqvlTLKAEENDLDEQLLLLPEELEEEET 802
|
|
| PRK06948 |
PRK06948 |
ribonucleotide reductase-like protein; Provisional |
63-728 |
7.22e-91 |
|
ribonucleotide reductase-like protein; Provisional
Pssm-ID: 180772 [Multi-domain] Cd Length: 595 Bit Score: 300.17 E-value: 7.22e-91
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 63 ETEISEEVYGQNY-QYGTDDRVpDTWYRNARAMAQVE--DDTDMWTQRFYQLLSGKGLGtgpfpftpGGRIFANAGTGLG 139
Cdd:PRK06948 12 EQPICDAVFADRYaLPGETSRA-QVFARVARALALAEppDTRAGAARRFYRNLLNGAIG--------AGRIMANAGAAPD 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 140 kATLINCFV-----SGFQGHDQDSMDEI--QAELTrqakiLASEGGYGFCAHIMRPRGARIGGVGSMTPGAVQMLDVWNK 212
Cdd:PRK06948 83 -QTMVNCFVhpiraPAALTAVHPNLDRAldDARLT-----LLMGGGIGYDFSAIPPADARPDADHPDSPGVCAALDRFDR 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 213 QAATIVAGSGmksdrddvkdkiRKGAQMVTMGIWHPDIIEFIEAKQEPGRLHKFNMSVLITDEFMEAVKNDDTWALRFPd 292
Cdd:PRK06948 157 ICAALPFRDG------------RRGAQMAVLRCDHPDLLAFVAAKRGRARWTTFNLSVAVTDAFMQAVAQDLPWALRHR- 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 293 yenekefyKQHWDGNLKAYQEKGGTvktWTdpatgePAVYEAREIWNRIMDSTYNRNEPGVIFVDTINKENNLGYVEHIN 372
Cdd:PRK06948 224 --------APPRRAAGGALRGADGA---WT------YATVPARHLWREIVSAARDSAEPGLLFVDTIDAANPLREHERID 286
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 373 ATNPCGEQVLPVGGVCLLGNLNVTQLVDREAGT-----IDYDLVDDLVPLAVRFLDNVNDLSYVPLEEQQRNLQEKRRIG 447
Cdd:PRK06948 287 ATNPCGEQPLPPYGSCVLGPIDLSRFVRHPFGVggeprFDFAALATAVRIQVRMLDNALDLTRWPLAAHAREARQKRRIG 366
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 448 LGHYGDGSALMMMKTRYGSEEGARVMREFQEHLANQAYQASARLAEEKGAFPLFDKDEYLSSP-FVQRLSDKTKEMIGDL 526
Cdd:PRK06948 367 VGVTGLADALTMMRLRYDSPAAREMARYIASDLRHHAYAASAALAAERGAYPLCDPAAHLDALrAGPPLPHAVCHAIARH 446
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 527 GLRNSHLLSIQPTGNTS-TLGNAPSSGIEPVFMHSYIRTSEqpaLPDGINRPPMSPN-AYEVGQDIdadgtawtaeeQGD 604
Cdd:PRK06948 447 GLRNSHLLSFAPVGSVSlAFGDNCSPGIEPARAWIEHRPVR---AGAGGARGMRAENhAYRLFRSL-----------RGE 512
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 605 ETVLrcqeeghthwqihptrdickdqevkdyavrhmetdgtwdpdADWAVTTRDLDVDDHLTQMKALAPFVDSSMSKTVN 684
Cdd:PRK06948 513 RAAL-----------------------------------------PDYFVTAADVAPADHLAMRAALQPYVDAGISKTVT 551
|
650 660 670 680
....*....|....*....|....*....|....*....|....
gi 1425874908 685 VPNDYPFEDFKELYKKAHDTGvIKGVTTYRAGTMSAVLSGEDDG 728
Cdd:PRK06948 552 LPNHYSLAEVDALLFQAWRAG-LKGITIFRPDPALDAVPSDDDA 594
|
|
| NrdE_NrdA |
TIGR02506 |
ribonucleoside-diphosphate reductase, alpha subunit; This model represents the alpha (large) ... |
82-713 |
8.14e-71 |
|
ribonucleoside-diphosphate reductase, alpha subunit; This model represents the alpha (large) chain of the class I ribonucleotide reductase (RNR). RNR's are responsible for the conversion of the ribose sugar of RNA into the deoxyribose sugar of DNA. This is the rate-limiting step of DNA biosynthesis. Class I RNR's generate the required radical (on tyrosine) via a "non-heme" iron cofactor which resides in the beta (small) subunit. The alpha subunit contains the catalytic and allosteric regulatory sites. The mechanism of this enzyme requires molecular oxygen. E. Coli contains two versions of this enzyme which are regulated independently (NrdAB and NrdEF, where NrdA and NrdE are the large chains). Most organisms contain only one, but the application of the gene symbols NrdA and NrdE are somewhat arbitrary. This model identifies RNR's in diverse clades of bacteria, eukaryotes as well as numerous DNA viruses and phage. [Purines, pyrimidines, nucleosides, and nucleotides, 2'-Deoxyribonucleotide metabolism]
Pssm-ID: 274170 [Multi-domain] Cd Length: 617 Bit Score: 246.14 E-value: 8.14e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 82 RVPDTWYRNARAMAQVE-DDTDM-WTQRFYQLLSGkglgtgpFPFTPGGRIFANAGTGlgKATLINCFVSGFqghDQDSM 159
Cdd:TIGR02506 24 SPQEAYMRVAMGLASLEpKDTRLaDAIRFYDLLSR-------LKISPATPTLFNAGTP--RGQLSSCFLLDV---TDDTL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 160 DEIQAELTRQAKILASEGGYGFCAHIMRPRGARIGGVGSMTPGAVQMLDVWNKQAATIVAGSgmksdrddvkdkIRKGAQ 239
Cdd:TIGR02506 92 ESIYKAIDDVAQLSKHGGGIGLNLTKLRAIGSPIRGTNNASKGIIPFLKLLDSSVEAVNQGG------------KRPGAA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 240 MVTMGIWHPDIIEFIEAKQEPG----RLHKFNMSVLITDEFMEAVKNDDTWALRFPDY-ENEKEFYKQHWDGNLKAYQEK 314
Cdd:TIGR02506 160 AVYLEVWHPDIEEFLDLKKNNGderrRCDNLFYGLWIPDLFMKRVEEDKDWYLFSPYDvPGLYGLYGEEFEEEYERLEKD 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 315 GGTVKTWTdpatgepaVYEAREIWNRIMDSTYNRNEPGVIFVDTINKEN-NLGYVEHINATNPCGEQVLPVG-------G 386
Cdd:TIGR02506 240 VEARKKIR--------KVSARDLMKDILRTRVETGRPYILFKDAVNKHNpFKTGGGAIKMSNLCTEITQPTDdshkgetA 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 387 VCLLGNLNVTQLVDREagTIDYDLVDDLVPLAVRFLDNVNDLSYVPLEEQQRNLQEKRRIGLGHYGDGSALMMMKTRYGS 466
Cdd:TIGR02506 312 VCNLASVNLANFVMED--KFDFSELEDAVRIAVRFLDNVIDLQNYPTAPAAKSNQRRRSIGIGVMGLHDVLAKLGLPYDS 389
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 467 EEGARVMREFQEHLANQAYQASARLAEEKGAFPLFDKDEY------------LSSPFVQ---------RLSDKTKEMigd 525
Cdd:TIGR02506 390 EEARDLNDRIFEAIYYYAIKASAELAKEKGPFPGFSGSKYakgwlhpdtwekTIDPKTSmapteedweALRERIKEY--- 466
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 526 lGLRNSHLLSIQPTGNTSTLGNApSSGIEPVFMHSYIRTSeqpalpdgINRPPMSPNAYEVGQDIDADgtAWTAEEQGde 605
Cdd:TIGR02506 467 -GLRNSQLTALMPTASSSQLTGV-TESIEPVFSNIFTKKT--------LSGEFLIPNKYLMKELEELG--LWDADRRG-- 532
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 606 tvlrcqeeghthwqihptrdickDQEVKDYAVRHmetdGTWDPDADWAV--TTRDLDVDDHLTQMKALAPFVDSSMSKTV 683
Cdd:TIGR02506 533 -----------------------DIVENVGSPQP----IAAIPETLKYKykTAYELDQEALIDMAADRQKFVDQSISLNL 585
|
650 660 670
....*....|....*....|....*....|
gi 1425874908 684 NVPNDYPFEDFKELYKKAHDTGViKgvTTY 713
Cdd:TIGR02506 586 FLTEEVTAKDLLKLLLLAWKKGL-K--TMY 612
|
|
| PRK06406 |
PRK06406 |
vitamin B12-dependent ribonucleotide reductase; |
99-717 |
4.23e-67 |
|
vitamin B12-dependent ribonucleotide reductase;
Pssm-ID: 235796 [Multi-domain] Cd Length: 771 Bit Score: 239.37 E-value: 4.23e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 99 DDTDMWTQRFYQLLSGKglgtgpfPFTPGGRIFANAGTGLGKatLINCFVSGFQghdqDSMDEIQAELTRQAKILASEGG 178
Cdd:PRK06406 214 DSIEEYINKFEEVMSNL-------KFVPNSPTLMNAGTKLGQ--LSACFVLPVP----DSIEGIFNALKYTAMIHKSGGG 280
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 179 YGFCAHIMRPRGARIGGVGSMTPGAVQMLDVWNkqAATIVAGSGMKsdrddvkdkiRKGAQMVTMGIWHPDIIEFIEAKQ 258
Cdd:PRK06406 281 TGFSFSRLRPKDDIVASTKGVASGPLSFMRIFD--VTTDVIKQGGK----------RRGANMGILSYHHPDIMEFITSKD 348
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 259 EPGR-LHKFNMSVLITDEFMEAVKNDDTWALRFPdyENEKEFYKqhwdgnlkayqekggtvktwtdpatgepavYEAREI 337
Cdd:PRK06406 349 SENKvLSNFNISVAVTDEFFDKLDNDDYYPLRNP--RNGKEVKR------------------------------IKARQV 396
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 338 WNRIMDSTYNRNEPGVIFVDTINKENNLGYVEHINATNPCGEQVLPVGGVCLLGNLNVTQLVdrEAGTIDYDLVDDLVPL 417
Cdd:PRK06406 397 WDLIITQAWKTGDPGVIFLDEINRKNPVKNLGEIESTNPCGEQPLLPYESCNLGSINLSKFV--ENGKIDWDRLRETVHI 474
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 418 AVRFLDNVNDLSYVPLEEQQRNLQEKRRIGLGHYGDGSALMMMKTRYGSEEGARVMREFQEHLANQAYQASARLAEEKGA 497
Cdd:PRK06406 475 ATRFLDNVIDANKFPVPQIKEMTRMTRKIGLGVMGFADMLIKLGIPYNSEEALEIAEKVMKFINEESHRASQKLAEERGV 554
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 498 FPLFDKDEYlsspfvqrlsdkTKEMIgdlGLRNSHLLSIQPTGNTSTLGNApSSGIEPVFMHSYIRTseqpaLPDGINRP 577
Cdd:PRK06406 555 FPAWYGSEW------------EKKGI---KMRNSTTTTIAPTGTISIIAGC-SSSIEPLFAIAFVRH-----VLNGQELL 613
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 578 PMSPNAYEVgqdidadgtawtAEEQG---DETVLRCQEEGHthwqihpTRDICKDQEVKDYAVRHMETDGTWdpdadwav 654
Cdd:PRK06406 614 EVNPLFEEI------------TRKRGlysEELMRKVAETGN-------LQNIDVPEDIKRIFVTAHEIDPQW-------- 666
|
570 580 590 600 610 620
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1425874908 655 ttrdldvddHLTQMKALAPFVDSSMSKTVNVPNDYPFEDFKELYKKAHDTGViKGVTTYRAGT 717
Cdd:PRK06406 667 ---------HVLMQATFQRYCDSGVSKTINLRYDATPEDIAKAYRLAKDLHC-KGITVYRDKS 719
|
|
| RNR_I |
cd01679 |
Class I ribonucleotide reductase; Ribonucleotide reductase (RNR) catalyzes the reductive ... |
85-597 |
2.99e-56 |
|
Class I ribonucleotide reductase; Ribonucleotide reductase (RNR) catalyzes the reductive synthesis of deoxyribonucleotides from their corresponding ribonucleotides. It provides the precursors necessary for DNA synthesis. RNRs are separated into three classes based on their metallocofactor usage. Class I RNRs, found in eukaryotes, bacteria, and many viruses, use a diiron-tyrosyl radical. Class II RNRs, found in bacteria, bacteriophage, algae and archaea, use coenzyme B12 (adenosylcobalamin, AdoCbl). Class III RNRs, found in anaerobic bacteria, bacteriophages, and archaea, use an FeS cluster and S-adenosylmethionine to generate a glycyl radical. Many organisms have more than one class of RNR present in their genomes. All three RNRs have a ten-stranded alpha-beta barrel domain that is structurally similar to the domain of PFL (pyruvate formate lyase). Class I RNR is oxygen-dependent and can be subdivided into classes Ia (eukaryotes, prokaryotes, viruses and phages) and Ib (which is found in prokaryotes only). It is a tetrameric enzyme of two alpha and two beta subunits; this model covers the major part of the alpha or large subunit, called R1 in class Ia and R1E in class Ib.
Pssm-ID: 153088 [Multi-domain] Cd Length: 460 Bit Score: 201.23 E-value: 2.99e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 85 DTWYRNARAMAQveDDTDmWTQRFYQLLSGkglgtgpFPFTPGGRIFANAGTGLGKatLINCFVSgfqgHDQDSMDEIQA 164
Cdd:cd01679 3 DRLMRVALGLAS--GDLE-WAKEFYDLLSK-------QRFTPATPTLFNAGTPRGQ--LSSCFLL----TVDDSLESIYD 66
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 165 ELTRQAKILASEGGYGFCAHIMRPRGARIGGVGSMTPGAVQMLDVWNkqaATIVAGSGMKSdrddvkdkiRKGAQMVTMG 244
Cdd:cd01679 67 TIKECAQLSKIGGGIGLNLSNIRATGSPIRGTNGASNGVIPFLKLLN---DTARYVDQGGQ---------RKGAGAVYLE 134
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 245 IWHPDIIEFIEAKQEPG----RLHKFNMSVLITDEFMEAVKnddtwalrfpdyenekefykqhwdgnlkayqekggtvkt 320
Cdd:cd01679 135 IWHPDIEEFLDLKKNNGderrRARDLFYGVWIPDLFMERVE--------------------------------------- 175
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 321 wtdpatgepavyeaREIWNRIMDSTYNRNEPGVIFVDTINKENNLGYVEHINATNPCGEQVLPVGG---------VCLLG 391
Cdd:cd01679 176 --------------RDLWRKILESQFETGYPYILFKDTCNRKNPQKHLGTIKSSNLCTEILQPTSPsedepgedaVCNLA 241
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 392 NLNVTQLVDREAgtidydlVDDLVPLAVRFLDNVNDLSYVPLEEQQRNLQEKRRIGLGHYGDGSALMMMKTRYGSEEGAR 471
Cdd:cd01679 242 SINLGNFVTFEK-------LEEVVKLAVRALDNVIDLNYYPVPEAKRSNMRHRAIGLGVMGLHDYLALLRIPYESEEALD 314
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 472 VMREFQEHLANQAYQASARLAEEKGafplfdkdeylsspfvqrlsdktkemigdlGLRNSHLLSIQPTGNTSTLGNApSS 551
Cdd:cd01679 315 LNDRIFETINYYALKASCELAKERG------------------------------GLRNSLLLAIAPTASISQILGA-TP 363
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*..
gi 1425874908 552 GIEPVFMHSYIRTSEQ-------PALPDGINRPPMSPNAYEVGQD--ID--ADGTAW 597
Cdd:cd01679 364 SIEPITSNIYVRRVLSgefpvvnPHLEKDLWEYGLYKTAYEIDQRwlIDlaADRQKH 420
|
|
| PRK09102 |
PRK09102 |
ribonucleoside-diphosphate reductase subunit alpha; |
106-559 |
5.48e-41 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 236378 [Multi-domain] Cd Length: 601 Bit Score: 160.12 E-value: 5.48e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 106 QRFYQLLSgKGLgtgpfpFTPGGRIFANAGTGLGKAtlINCFVSgfqgHDQDSMDEIQaELTRQAKILASEGGyGFCAHI 185
Cdd:PRK09102 60 QRFYDYMS-RGW------FMPATPVLSNGGTDRGLP--ISCFLN----YVEDSLEGIV-NTWNENVWLAKRGG-GIGSYW 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 186 --MRPRGARIGGVGSmTPGAVQMLDVWNKQAATIVAGSgmksdrddvkdkIRKGAQMVTMGIWHPDIIEFIEAKQEPGRL 263
Cdd:PRK09102 125 gnVRSIGEPIRNNGK-SSGIIPFIKVMDSLTLAISQGS------------LRRGSFAVYLDIEHPEIEEFLDIRKPTGDP 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 264 HK--FNM--SVLITDEFMEAVKNDDTWALRFPdyenekefykqhwdgnlkayqeKGGTVKTwtdpatgepaVYEAREIWN 339
Cdd:PRK09102 192 NRkaLNLhhGVCVTDEFMEAVEDGDEWDLISP----------------------KDKSVIR----------TVKARDLWA 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 340 RIMDSTYNRNEPGVIFVDTIN-------KENNLgyveHINATNPCGEQVLPVGG---------VCLLGNLNVtQLVDREA 403
Cdd:PRK09102 240 KILETRIETGEPYLLFIDNVNralpevyKDLGL----KVKASNLCSEITLPTGIdhlgedrtaVCCLSSLNL-EYYDEWK 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 404 GTidydlvDDLVPLAVRFLDNVndlsyvpLEE---QQRNLQEK--------RRIGLGHYGDGSALMMMKTRYGSEEGARV 472
Cdd:PRK09102 315 DT------DAFIEDLMRFLDNV-------LQDfidKAPDEMERakysamreRSVGLGVMGFHSYLQSKMIPFESVMAKQW 381
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 473 MREFQEHLANQAYQASARLAEEKGAFPlfDKDEYlsspfvqrlsdktkemigDLGLRNSHLLSIQPTGNTS-TLGNApSS 551
Cdd:PRK09102 382 NKKIFKHIREQADKASKELAKEKGECP--DAAGY------------------GVMRRFSTKMAIAPTASISiILGNT-SP 440
|
490
....*....|..
gi 1425874908 552 GIEP----VFMH 559
Cdd:PRK09102 441 GIEPiaanYYTH 452
|
|
| PRK12365 |
PRK12365 |
ribonucleoside-diphosphate reductase subunit alpha; |
87-565 |
4.96e-40 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 171440 [Multi-domain] Cd Length: 1046 Bit Score: 160.50 E-value: 4.96e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 87 WYRNARAMAQVE-DDTDMWTQRFYQLLSgkglgtgPFPFTPGGRIFANagTGLGKATLINCFVSGFQghdqDSMDEIQAE 165
Cdd:PRK12365 406 WMRVSMGLALNEgQDKTSWAITFYNLLS-------TFRYTPATPTLFN--SGMRHSQLSSCYLSTVQ----DDLVHIYKV 472
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 166 LTRQAKILASEGGYGFCAHIMRPRGARIGGVGSMTPGAVQMLDVWNKQAatIVAGSGMKsdrddvkdkiRKGAQMVTMGI 245
Cdd:PRK12365 473 ISDNAMLSKWAGGIGNDWTAVRATGALIKGTNGKSQGVIPFIKVANDTA--VAVNQGGK----------RKGAVCVYLEV 540
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 246 WHPDIIEFIEAKQEPG----RLHKFNMSVLITDEFMEAVKNDDTWALRFPD-YENEKEFYKQHWDgnlKAYQEKGGTVKT 320
Cdd:PRK12365 541 WHLDYEDFLELRKNTGderrRTHDINTASWIPDLFFKRLQQKGTWTLFSPDdVPGLHEAYGEEFE---KLYEEYERKVDT 617
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 321 wtdpatGEPAVY---EAREIWNRIMDSTYNRNEPGVIFVDTINKENNLGYVEHINATNPCGEQVLPVG----GVCLLGNL 393
Cdd:PRK12365 618 ------GEIRLYkkvEAEDLWRKMLSMLYETGHPWMTFKDPSNIRSAQDHKGVVRCSNLCTEILLNCSetetAVCNLGSI 691
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 394 NVTQLVdrEAGTIDYDLVDDLVPLAVRFLDNVNDLSYVPLEEQQRNLQEKRRIGLGHYGDGSALMMMKTRYGSEEGARVM 473
Cdd:PRK12365 692 NLVEHI--VNDGLDEEKLSETISIAIRILDNVIDINFYPTKEAKEANLAHRAIGLGVMGFQDALYKLNISYASQEAVEFA 769
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 474 REFQEHLANQAYQASARLAEEKGAFPLFDKDE----YLSSPFVQRLSD------------------KTKEMIGDLGLRNS 531
Cdd:PRK12365 770 DYSSELIAYYAILASSLLAKERGTYSSYKGSKwdrgYLPIDTIELLKEyrgeanllmdtssrkdwePVRSLIKEYGMRNS 849
|
490 500 510
....*....|....*....|....*....|....
gi 1425874908 532 HLLSIQPTGNTSTLGNAPSSgIEPVFMHSYIRTS 565
Cdd:PRK12365 850 QLMAIAPTATISNIIGVTQS-IEPTYKHLFVKSN 882
|
|
| PRK09209 |
PRK09209 |
ribonucleoside-diphosphate reductase subunit alpha; |
131-561 |
2.48e-38 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 181700 [Multi-domain] Cd Length: 761 Bit Score: 153.73 E-value: 2.48e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 131 FANAGTGLGKatLINCFVSGFQghdqDSMDEIQAELTRQAKILASEGGYGFCAHIMRPRGARIGGVGSMTPGAVQmldvW 210
Cdd:PRK09209 224 LANAGKVGGQ--LSSCFIDTVD----DSLQGIYDSNTDVARVSKHGGGVGAYLGKVRSRGSDIRGFKGVSSGVIP----W 293
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 211 NKQ---AATIVAGSGMksdrddvkdkiRKGAQMVTMGIWHPDIIEFIEAKQEPG----RLHKFNMSVLITDEFMEAVKND 283
Cdd:PRK09209 294 IKQlnnTAVSVDQLGQ-----------RKGAIAVYLDVWHKDIESFLDLRLNNGderlRAHDVFTGVCIPDLFMEAVERR 362
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 284 DTWALrFPDYENEK-------EFYKQhwdgnlkayQEKGGTVKTWTDPATGEPAV----YEAREIWNRIMDSTYNRNEPG 352
Cdd:PRK09209 363 GDWYL-FDPHEVKKvmgwyleDFYDE---------KKGDGSFREKYEECVADERLsrktVKAIDIMKRIMVSQLETGNPF 432
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 353 VIFVDTINKENNLGYVEHINATNPCGE-----------QVLPVGG------------VCLLGNLNVTQLVDReagtidyD 409
Cdd:PRK09209 433 MFYRDEVNRMNPNKHEGMIYSSNLCTEimqnmsptvmiQEIISGGqivitkqpgdfvVCNLSSINLGRAVTA-------D 505
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 410 LVDDLVPLAVRFLDNVNDLSYVPLEEQQRNLQEKRRIGLGHYGDGSALMMMKTRYGSEEGARVMREFQEHLANQAYQASA 489
Cdd:PRK09209 506 VLERLIPIQVRMLDNVIDLNQLPVPQATITNQKYRAIGLGTFGWHHLLALKGIAWESEEAVQYADELYERINYLTIQASM 585
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1425874908 490 RLAEEKGAFPLFDKDEYLSSPFVQRLS------DKTKEMIGDLGLRNSHLLSIQPTGNTSTLGNAPSSgIEPVFMHSY 561
Cdd:PRK09209 586 ELAKEKGAYPVFKGSDWQTGEYFERRGynspqwDELAAQVAENGVRNAYLMAVAPNMSTAQIAGSTAS-IDPIYSAFY 662
|
|
| PRK07088 |
PRK07088 |
ribonucleoside-diphosphate reductase subunit alpha; |
93-562 |
8.67e-36 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 180831 [Multi-domain] Cd Length: 764 Bit Score: 145.72 E-value: 8.67e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 93 AMAQVEDDTDMWTQRFYQLLSGKGLGTGpfpfTPggrIFANAGTGLGKatLINCFVSGFQghdqDSMDEIQAELTRQAKI 172
Cdd:PRK07088 195 AIPEGKEKRVYYAKKFYDLLSELKATVA----TP---TLSNAGTPFYQ--LSSCFISVVD----DNLWSIYDVNQKFAQV 261
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 173 LASEGGYGFCAHIMRPRGARIGGVGSMTPGAVQMLDVWNKQAATIvagsgmksdrddvkDKI--RKGAQMVTMGIWHPDI 250
Cdd:PRK07088 262 SKHGGALGIYTGKIRALNSEIRGFKNASGGVIPWIKLYNDTAIAV--------------DQLgkRKGGAAITLDIWHKDI 327
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 251 IEFIEAKQEPG----RLHKFNMSVLITDEFMEAVKNDDTWALRFP------------DY---ENEKEFYKQHW----DGN 307
Cdd:PRK07088 328 PEFLDLKTNNGddrrKAHDIFPGVSYPDLFMKRLEKRENWSLFDPheikkvkgysleDYydeEDRKEFTKKYLeceeDTN 407
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 308 LkayqekggtvktwtdpatgEPAVYEAREIWNRIMDSTYNRNEPGVIFVDTINKENNLGYVEHINATNPC---------- 377
Cdd:PRK07088 408 I-------------------PRRTVPVLDIMKKIMKSAVETGTPFIFFRDTVNKANPNKHKGMIYSSNLCheiaqnmses 468
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 378 ---GEQVLPVGGVCLL------GNLNVTQLVDREAGTIDYDLVDDLVPLAVRFLDNVNDLSYVPLEEQQRNLQEKRRIGL 448
Cdd:PRK07088 469 ellEEEIIDENGYYEVvqkikaGDMVTCNLNSIVLGNVDDEELEEVIPTQIRMLDNVISLNYYPVPEAEITSDKYRAIGL 548
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 449 GHYGDGSALMMMKTRYGSEEGARVMREFQEHLANQAYQASARLAEEKGAFPLFDKDEYLSSPFVQRL---SDKTKEMIGD 525
Cdd:PRK07088 549 GTSGYHHMLANNKIRWESDEHIKFADKIYEEIAYYAIKASMELAKEKGSYPAFKGSEWETGKYFERRgynSERWKKLKEE 628
|
490 500 510 520
....*....|....*....|....*....|....*....|
gi 1425874908 526 L---GLRNSHLLSIQPTGNTSTLGNApSSGIEPVFMHSYI 562
Cdd:PRK07088 629 IkkyGMRNGYITAVAPTGSTSNIANT-TAGIDPVFKRFFM 667
|
|
| PRK06539 |
PRK06539 |
ribonucleoside-diphosphate reductase subunit alpha; |
71-565 |
1.83e-33 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 180610 [Multi-domain] Cd Length: 822 Bit Score: 138.90 E-value: 1.83e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 71 YGQNYQYGTDDRVPDT-WYRNARAMAQVEDDTDMWTQRFYQLLSGkglgtgpFPFTPGGRIFANAGTGlgKATLINCFVS 149
Cdd:PRK06539 160 YGIRARNGDALEVPQYfWMRIAMGLSLNEDDPTSSALAFYEKMSK-------LEYLAAGSTLVNAGTP--YPQLSNCFVM 230
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 150 gfqgHDQDSMDEIqAELTRQAKILAS-EGGYGFCAHIMRPRGARIGGVGSMTPGAVQMLDVWNKQAATIVAGsGMKSdrd 228
Cdd:PRK06539 231 ----EMQDDIEHI-AKTTRDVMWLTKgTGGIGLSVSKLRAQGSPIRSNNTTSTGPIPFMHTIDSVLRAVSRG-GKKF--- 301
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 229 dvkdkirkGAQMVTMGIWHPDIIEFIEAKQEPG----RLHKFNMSVLITDEFMEAVKNDDTWALRFP-DYENEKEFYKQH 303
Cdd:PRK06539 302 --------GALCFYMENWHMDFPEFLDLRQNSGdpyrRTRTANTAVWISDEFMKRVQNDEDWYLFDPlETPDLNELYGKA 373
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 304 WDGNLKAY--QEKGGTVKTWTDpatgepavYEAREIWNRIMDSTYNRNEPGVIFVDTINKE---NNLGYvehINATNPCG 378
Cdd:PRK06539 374 FSKRYAQYveQAEAGRIRMFKR--------ITAREQFRAILMSLQTTSHPWLTWKDTINNRalnNNTGT---IHLSNLCT 442
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 379 EQVLPVG----GVCLLGNLNVTQ-LVDreaGTIDYDLVDDLVPLAVRFLDNVNDLSYVPLEEQQRNLQEKRRIGLGHYGD 453
Cdd:PRK06539 443 EICLPQDrdnvSVCNLASINLSRhLAD---GELDWAQLEESTRLAVRQLDNLIDITASSVKEADFSNQQNRAIGLGVMGF 519
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 454 GSALMMMKTRYGSEEGARVMREFQEHLANQAYQASARLAEEKGAFPLFDKDEYlSSPFVQRLS--------------DKT 519
Cdd:PRK06539 520 TDMVERLGYSYESEEAYDLIDRIMEHISYAAIDESADLAAERGAYPNFEGSRW-SRGMVPVDSialleadrgvpvdvNRT 598
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....
gi 1425874908 520 KEMIGDL-------GLRNSHLLSIQPTGNTSTL-GNAPssGIEPVFMHSYIRTS 565
Cdd:PRK06539 599 TRLDWDAlrakvrgGMRNATLMAIAPTASIGLVaGTTP--GLDPQFSQIFSRST 650
|
|
| PLN02437 |
PLN02437 |
ribonucleoside--diphosphate reductase large subunit |
133-563 |
8.78e-33 |
|
ribonucleoside--diphosphate reductase large subunit
Pssm-ID: 178056 [Multi-domain] Cd Length: 813 Bit Score: 136.41 E-value: 8.78e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 133 NAGTGlgKATLINCFVSGFQghdQDSMDEIQAELTRQAKILASEGGYGFCAHIMRPRGARIGGVGSMTPGAVQMLDVWNK 212
Cdd:PLN02437 207 NAGTP--RPQLSSCFLICMK---DDSIEGIYDTLKECAVISKSAGGIGLSVHNIRATGSYIRGTNGTSNGIVPMLRVFND 281
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 213 QAATIVAGSGMksdrddvkdkiRKGAQMVTMGIWHPDIIEFIEAKQEPG----RLHKFNMSVLITDEFMEAVKNDDTWAL 288
Cdd:PLN02437 282 TARYVDQGGGK-----------RKGAFAIYLEPWHADIFEFLDLRKNHGkeehRARDLFYALWIPDLFMERVQSNGDWSL 350
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 289 RFPdyeNE---------KEFYKqhwdgnLKAYQEKGGTVKTwtdpatgepaVYEAREIWNRIMDSTYNRNEPGVIFVDTI 359
Cdd:PLN02437 351 FCP---NEapgladcwgEEFER------LYTKYEREGKAKK----------VVQAQQLWFAILESQIETGTPYMLFKDSC 411
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 360 NKENNLGYVEHINATNPCGEQVLPVG----GVCLLGNLNVTQLVdREAG-------------------TIDYDLVDDLVP 416
Cdd:PLN02437 412 NRKSNQQNLGTIKSSNLCTEIIEYTSptetAVCNLASIALPRFV-REKGvpleshpsklvgslgsknrYFDFEKLAEVTA 490
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 417 LAVRFLDNVNDLSYVPLEEQQRNLQEKRRIGLGHYGDGSALMMMKTRYGSEEGARVMREFQEHLANQAYQASARLAEEKG 496
Cdd:PLN02437 491 VVTRNLNKIIDVNYYPVETARRSNMRHRPIGIGVQGLADAFILLGMPFDSPEAQQLNKDIFETIYYHALKASSELAAREG 570
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 497 AFplfdkDEYLSSPFVQRL----------SDK-----TKEMIGDLGLRNSHLLSIQPTGNTST-LGNAPSsgIEPVFMHS 560
Cdd:PLN02437 571 PY-----ETYAGSPVSKGIlqpdmwgvtpSGRwdwaaLREMISKNGVRNSLLVAPMPTASTSQiLGNNEC--FEPYTSNI 643
|
...
gi 1425874908 561 YIR 563
Cdd:PLN02437 644 YSR 646
|
|
| PRK06556 |
PRK06556 |
vitamin B12-dependent ribonucleotide reductase; Validated |
157-716 |
4.81e-32 |
|
vitamin B12-dependent ribonucleotide reductase; Validated
Pssm-ID: 235828 [Multi-domain] Cd Length: 953 Bit Score: 134.71 E-value: 4.81e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 157 DSMDEIQAELTRQAKILasEGGYGFCAHIMRPRGAR----IGGVGSmtpGAVQMLDVWNKQAATIVAGSgmksdrddvkd 232
Cdd:PRK06556 159 DSMESILNWYKEEGMLF--KGGSGTGTNLSRIRSSKellsGGGTAS---GPVSFMRGADASAGTIKSGG----------- 222
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 233 KIRKGAQMVTMGIWHPDIIEFIE--AKQEpgrlHK--------FNM-----------------SVLITDEFMEAVKNDDT 285
Cdd:PRK06556 223 ATRRAAKMVILDVDHPDIEEFIEtkAKEE----DKiralrdagYDMdlggeayssvqyqnannSVRVSDEFMRAVENDGE 298
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 286 WALRfpdyenekefykqhwdgnlkayqekggtvkTWTDPATGEpaVYEAREIWNRIMDSTYNRNEPGVIFVDTIN----- 360
Cdd:PRK06556 299 FGLR------------------------------ARTDGEVIE--TVDAKELFRKIAEAAWECADPGIQYDDTINdwhtc 346
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 361 KENNlgyveHINATNPCGEQVLPVGGVCLLGNLNVTQLVdREAGTIDYDL---VDDLVPLAvrfLDNVNDLSYVPLEEQQ 437
Cdd:PRK06556 347 PESG-----RINASNPCSEYMFLDNSSCNLASLNLMKFL-RDDGTFDVESfrhAVELVITA---MEISICFADFPTEKIA 417
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 438 RNLQEKRRIGLGHYGDGSALMMMKTRYGSEEGARVMREFQEHLANQAYQASARLAEEKGAFPLFDKDEylsSPF--VQRL 515
Cdd:PRK06556 418 RNTRAFRQLGLGYANLGALLMATGLPYDSDGGRALAAAITSLMTGEAYRRSAELAGVVGPFEGYARNA---EPHlrVMRK 494
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 516 S-------DKTKEMIGDL------------------GLRNSHLLSIQPTGNTSTLGNAPSSGIEPVFMHSYIR------- 563
Cdd:PRK06556 495 HaaandaiRPLGEVDAALleaakeawddalelgeknGYRNAQASVLAPTGTIGFMMDCDTTGIEPDFALVKYKklvgggs 574
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 564 -TSEQPALPDGINRPPMSPNAYE-VGQDIDADGTAWTAEEQGDEtvlrcqeeghtHWqihptrdickdqEVKDYAVRHme 641
Cdd:PRK06556 575 mKIVNQTVPRALKKLGYSEEQIEaIVEYIAEHGHIEGAPGLKPE-----------HY------------AVFDCAMKP-- 629
|
570 580 590 600 610 620 630
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1425874908 642 tdgtwdpdadwAVTTRDLDVDDHLTQMKALAPFVDSSMSKTVNVPNDYPFEDFKELYKKAHDTGViKGVTTYRAG 716
Cdd:PRK06556 630 -----------ASGERSISPMGHVRMMAAVQPFLSGAISKTVNMPEDATVEDIEEVYLEGWKLGL-KALAIYRDN 692
|
|
| PRK08332 |
PRK08332 |
vitamin B12-dependent ribonucleotide reductase; |
366-719 |
3.17e-31 |
|
vitamin B12-dependent ribonucleotide reductase;
Pssm-ID: 181392 [Multi-domain] Cd Length: 1740 Bit Score: 132.58 E-value: 3.17e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 366 GYVEHinatnPCGEQVLPVGGVCLLGNLNVTQLVD-REAGT--IDYDLVDDLVPLAVRFLDNVNDLSYVPLEEQQRNLQE 442
Cdd:PRK08332 1291 GFMSH-----NCGEEPLYEYESCNLASINLAKFVKyDENGKpyFDWDEYAYVIQKVAKYLDNAIDVNKFPLPEIDYNTKL 1365
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 443 KRRIGLGHYGDGSALMMMKTRYGSEEGARVMREFQEHLANQAYQASARLAEEKGAFPLFDKDEY---------LSSPFVQ 513
Cdd:PRK08332 1366 TRRIGVGMMGLADALFKLGIPYNSEEGFKFMRKVTEYLTFYAYKYSVEAAKKRGTFPLYEKTEYpkgelpvegFYHPEIW 1445
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 514 RLS-DKTKEMIGDLGLRNSHLLSIQPTGNTSTLGNApSSGIEPVFMHSYIRTseqpalpdginrppmspnaYEVGQDIDA 592
Cdd:PRK08332 1446 NLPwDKLVEEIKKYGVRNAMVTTCPPTGSVSMIADT-SSGIEPIFALVYKKS-------------------VTVGEFYYV 1505
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 593 DgTAWTAEEQgdetvlrcqeeghthwqihpTRDICKDQEVKDYAVRHMETDGTWDPDADWA---VTTRDLDVDDHLTQMK 669
Cdd:PRK08332 1506 D-PVFEAELK--------------------KRGLYSEELLKKISDNYGSVQGLEEIPEDMQrvfVTALDIHWLDHILAQA 1564
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 1425874908 670 ALAPFVDSSMSKTVNVPNDYPFEDFKELYKKAHDTGViKGVTTYRAGTMS 719
Cdd:PRK08332 1565 NIQMWLTDSASKTINMINEATVEDVKAAYLIAHFLGC-KGVTVYRDGSLS 1613
|
|
| PRK08447 |
PRK08447 |
ribonucleoside-diphosphate reductase subunit alpha; |
91-590 |
1.24e-30 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 236266 [Multi-domain] Cd Length: 789 Bit Score: 129.85 E-value: 1.24e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 91 ARAM--AQVEDDTDMWTQRFYQLLSgkglgtgPFPFTPGGRIFANAGTGlgKATLINCFVsgfqGHDQDSMDEIQAELTR 168
Cdd:PRK08447 168 AIAMflAQNELDPQKWAKKFYDVIS-------KFEVMLATPTLSNARTT--RHQLSSCYI----GSTPDNIEGIFDSYKE 234
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 169 QAKILASEGGYGFCAHIMRPRGARIGGVGSMTPGAVQMLDVWNKQAATIvagsgmksdrddvkDKI--RKGAQMVTMGIW 246
Cdd:PRK08447 235 MALLSKYGGGIGWDWSKVRAMGSYIDGHKNAAGGIIPFLKITNDIAIAV--------------DQLgtRKGAIAVYLEPW 300
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 247 HPDIIEFIEAKQEPG----RLHKFNMSVLITDEFMEAVKNDDTWALrFPDYENEK--EFYKQHWDGNLKAYQEKGGTVKT 320
Cdd:PRK08447 301 HMDISDFIDLRKNSGeerrRAHDLFPALWINDLFMKRVEEDAMWTL-FDPYECKDltELYGEEFEKRYLEYEKDEKIIKE 379
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 321 wtdpatgepaVYEAREIWNRIMDSTYNRNEPGVIFVDTINKENNLGYVEHINATNPC----------------------- 377
Cdd:PRK08447 380 ----------YINAKELWKKILTNYFETGLPFLCFKDNANRANPNAHAGIIRSSNLCteifqntapnhykikiefedgsi 449
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 378 -----------------------------GEQVL-----PVGG---VCLLGNLNVTQLVDREAgtidydlVDDLVPLAVR 420
Cdd:PRK08447 450 effeeeelvtvdsgitkkakkitsldslkGKKIYivekeKKDGktaVCNLASINLSKINTKED-------IERVVPIAIR 522
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 421 FLDNVNDLSYVPLEEQQRNLQEKRRIGLGHYGDGSALMMMKTRYGSEEGARVMREFQEHLANQAYQASARLAEEKGAFPL 500
Cdd:PRK08447 523 MLDNVIDLNFYPNRKVKATNLKSRAIGLGVMGEAQMLAEHKIAWGSKEHLEKIDEIMEQISYNAIDASSNLALEKGVYPD 602
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 501 FDKDEY--------LSSPFVQRLSD------------KTKEMIGDLGLRNSHLLSIQPTGNTSTLgNAPSSGIEPVFMHS 560
Cdd:PRK08447 603 FEGSNWskgifpidKANEEAKKLVErgglfdsacdweGLREKVKKDGMRNGYLMAIAPTSSISIL-VGTTQTIEPVYKRK 681
|
570 580 590
....*....|....*....|....*....|....*..
gi 1425874908 561 YIRTSEQPALPdgINRPPMSPN-------AYEVGQDI 590
Cdd:PRK08447 682 WFEENLSGLIP--VVVPNLSPEtwqyytpAYDLDQKD 716
|
|
| PRK12364 |
PRK12364 |
ribonucleoside-diphosphate reductase subunit alpha; |
93-595 |
1.36e-25 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 237077 [Multi-domain] Cd Length: 842 Bit Score: 113.69 E-value: 1.36e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 93 AMAQvEDDTDMWTQRFYQLLSGKGLGTGpfpfTPggrIFANAGTGLGKatLINCFVSGFQghdqDSMDEIQAELTRQAKI 172
Cdd:PRK12364 273 AMPE-KQDRMGWVKRFYDMLSKLKVTMA----TP---TLSNARKPFHQ--LSSCFIDTVP----DSLDGIYRSIDNFAQV 338
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 173 LASEGGYGFCAHIMRPRGARIGGVGSMTPGAVQmldvWNKQA---ATIVAGSGMksdrddvkdkiRKGAQMVTMGIWHPD 249
Cdd:PRK12364 339 SKFGGGMGLYFGKVRAVGSNIRGFQGVAGGVIR----WIKLAndtAVAVDQLGM-----------RQGAVAVYLDVWHKD 403
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 250 IIEFIEAKQEPG----RLHKFNMSVLITDEFMEAVKND--DTWALRFP------------DYENEkEFYKQHWDGNLKAY 311
Cdd:PRK12364 404 IPEFLQLRTNNGddrmKAHDVFPAVCYPDLFWKMVRDDinQSWYLFCPheiltvkgyaleDYYGE-EWEKRYLDCVNDAR 482
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 312 QEKGG---------TVKTWTDpaTGEPAVYeareiwNRimdSTYNRNEP----GVIFVDTINKE--NNLGYVEHINA--T 374
Cdd:PRK12364 483 ISKRSipikdlvrlILKSAVE--TGTPFTF------NR---DTVNRANPnkhkGMIYCSNLCTEiaQNMSAIETVSTeiE 551
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 375 NPCGEQVlpVGGVCLLGNLNVTQLVDREAGTIDYD---LVDDLVPLAVRFLDNVNDLSYVPLEEQQRNLQEKRRIGLGHY 451
Cdd:PRK12364 552 TEDGDTV--VVTTTRPGDFVVCNLASLSLGNIDLEdeeELEEVVRTVVRALDNVIDLNFYPVPYAQITNKRYRSIGLGVS 629
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 452 GDGSALMMMKTRYGSEEGARVMREFQEHLANQAYQASARLAEEKGAFPLFD----------KDEYLSSPFVQRLSDKTKE 521
Cdd:PRK12364 630 GYHHALAKNGIRWESEEHLEFADRVFERINYAAIKASMEIAKEKGAYGYFEgsdwqtgayfRKRGYTSEEWQRLAREVAE 709
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 522 MigdlGLRNSHLLSIQPTGNTSTLGNApSSGIEPVfMHSYIRTSEQ--------PALPDgiNRPPMSPNAYEVGQD--ID 591
Cdd:PRK12364 710 N----GMRNAYLLAVAPTSSTSIIAGT-TAGVDPV-MKRYFLEEKKgalmprvaPELSD--KTFWLYKNAHLIDQKwsIR 781
|
....
gi 1425874908 592 ADGT 595
Cdd:PRK12364 782 AAGV 785
|
|
| PRK07207 |
PRK07207 |
ribonucleoside-diphosphate reductase subunit alpha; |
89-563 |
2.33e-25 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 235966 [Multi-domain] Cd Length: 965 Bit Score: 113.13 E-value: 2.33e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 89 RNARAmaqVEddtdmwtqrFYQLLSGkglgtgpFPF---TPggRIFaNAGTGlgKATLINCF---VSgfqghdqDSMDEI 162
Cdd:PRK07207 338 REARA---IE---------FYNLLSS-------FDFmssTP--TLF-NSGTL--RPQLSSCYlttVP-------DDLDGI 386
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 163 QAELTRQAKILASEGGYGFCAHIMRPRGARIGGVGSMTPGAVQMLDVWNkqaATIVA-GSGMKsdrddvkdkiRKGAQMV 241
Cdd:PRK07207 387 YEAIKDNALLSKFAGGLGNDWTPVRALGSHIKGTNGKSQGVVPFLKVVN---DTAVAvNQGGK----------RKGAVCA 453
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 242 TMGIWHPDIIEFIEAKQEPG----RLHKFNMSVLITDEFMEAVKNDDTWALrF-----PDYENE--KEFYKQHwdgnlKA 310
Cdd:PRK07207 454 YLETWHLDIEEFLELRKNTGddrrRTHDMNTANWIPDLFMKRVMEDGEWTL-FspsevPDLHDLfgKAFEEAY-----TA 527
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 311 YQEKGgtvktwtdpATGEPAVYE---AREIWNRIMDSTYNRNEPGVIFVDTIN---KENNLGYVeHinATNPCGEQVLPV 384
Cdd:PRK07207 528 YEAKA---------ARGEIKLFKkipAVDLWRKMLSMLFETGHPWITFKDPCNlrsPQQHVGVV-H--SSNLCTEITLNT 595
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 385 GG----VCLLGNLNVTQLVDrEAGTIDYDLVDDLVPLAVRFLDNVNDLSY--VPleeQQRNLQEKRR-IGLGHYGDGSAL 457
Cdd:PRK07207 596 SDdeiaVCNLGSVNLVAHIK-DGAKLDHEKLKRTVSTAMRMLDNVIDINYyaVP---KARNSNLRHRpVGLGIMGFQDAL 671
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 458 MMMKTRYGSEEGARVMREFQEHLANQAYQASARLAEEKGAFPLFD--------------------KDEYLSSPFVQRLS- 516
Cdd:PRK07207 672 YLLRIPYASDEAVEFADRSMEAVSYYAIWASTELAEERGRYSSYEgslwsrgilpidslkllaeaRGGYLEVDRSSTLDw 751
|
490 500 510 520
....*....|....*....|....*....|....*....|....*....
gi 1425874908 517 DKTKEMIGDLGLRNSHLLSIQPtgnTSTLGN--APSSGIEPVFMHSYIR 563
Cdd:PRK07207 752 DALRARIKKHGMRNSNCMAIAP---TATISNiiGVSQSIEPTYQNLYVK 797
|
|
| nrdA |
PHA02572 |
ribonucleoside-diphosphate reductase subunit alpha; Provisional |
157-555 |
4.38e-20 |
|
ribonucleoside-diphosphate reductase subunit alpha; Provisional
Pssm-ID: 222883 [Multi-domain] Cd Length: 753 Bit Score: 95.94 E-value: 4.38e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 157 DSMDEIQAELTRQAKILASEGGYGFCAHIMRPRGARIGGvgsmtpGAVQMLDV---WNKQAATIVAGSgmksdrddvKDK 233
Cdd:PHA02572 230 DSLDSINKTAMAIVKYISKRAGIGINAGMIRAEGSKIRG------GEVRHTGVipfWKHFQTAVKSCS---------QGG 294
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 234 IRKGAQMVTMGIWHPDIIEFIEAKQEPG----RLHKFNMSVLITDEFMEAVKNDDTWALRFPDYENEKEFYKQHWDGN-- 307
Cdd:PHA02572 295 IRGGAATAYYPIWHLEVEDLLVLKNNKGveenRIRHLDYGVQINDLMYERFIKNDYITLFSPHDVGGELYDAYFADQDrf 374
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 308 --LKAYQEKGGTVKTwtdpatgepAVYEAREIWNRIMDStynRNEPGVIFVDTINKENNLG-YVEHINATNPCGEQVLPV 384
Cdd:PHA02572 375 reLYEALEKDPSVRK---------KRIKAQELFLLLLKE---RSETGRIYIMFIDHCNNHSpFKDPIRQSNLCCEIALPT 442
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 385 G-----------GVCLLGNLNVTQLVDReagtidyDLVDDLVPLAVRFLDNVNDLSYVPLEEQQRNLQeKRRIGLGHYGD 453
Cdd:PHA02572 443 KplnhidgegeiALCTLSAIVLGNFEDQ-------DEIEELAEVAVRALDNLLDYQDYPVPAALKAKK-RRSLGVGVTNY 514
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 454 GSALMMMKTRYGSEEGARVmREFQEHLANQAYQASARLAEEKGAFPLFDKDEY----------------LSSPFVQRLSD 517
Cdd:PHA02572 515 AHYLAKNFASYEDANADLV-HELFERLQYYLIKASNKLAKEKGACEYFSDTKYsrgelpidwykkkvdeLVAPKYNCDWE 593
|
410 420 430
....*....|....*....|....*....|....*...
gi 1425874908 518 KTKEMIGDLGLRNSHLLSIQPTGNTSTLGNApSSGIEP 555
Cdd:PHA02572 594 SLREDLKKYGIRNSTLSALMPCESSSQVSNS-TNGIEP 630
|
|
| PRK07562 |
PRK07562 |
vitamin B12-dependent ribonucleotide reductase; |
267-731 |
3.06e-18 |
|
vitamin B12-dependent ribonucleotide reductase;
Pssm-ID: 236049 [Multi-domain] Cd Length: 1220 Bit Score: 90.41 E-value: 3.06e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 267 NMSVLITDEFMEAVKNDDTWALRFpdyenekefykqhwdgnlkayQEKGGTVKTwtdpatgepavYEAREIWNRIMDSTY 346
Cdd:PRK07562 398 NNSVRVTDEFLRAVENDGDWNLTA---------------------RTDGKVAKT-----------LKARDLWEKIGYAAW 445
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 347 NRNEPGVIFVDTINKENNLGYVEHINATNPCGEQVLPVGGVCLLGNLNVTQLVDREAGTIDydlVDDLVPlAVRFLDNVN 426
Cdd:PRK07562 446 ASADPGLQFNTTINDWHTCPASGPIRASNPCSEYMFLDDTACNLASLNLLTFRDEDTKRFD---VEAYEH-ACRLWTVVL 521
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 427 DLSYV----PLEEQQRNLQEKRRIGLGHYGDGSALMMMKTRYGSEEGARVMREFQEHLANQAYQASARLAEEKGAFPLFD 502
Cdd:PRK07562 522 EISVLmaqfPSKEIAELSYEFRTLGLGYANIGGLLMTMGIPYDSDEGRAICGALSAIMTGVAYATSAEMAKELGPFPGYE 601
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 503 KD----------------------EYLSSPFV----------------QRLSDKTKEMIGDLGLRNSHLLSIQPTGntsT 544
Cdd:PRK07562 602 KNadhmlrvirnhrraahgesegyEGLSVNPVpldhancpdqdlvahaKAAWDKALELGEKHGYRNAQVTVIAPTG---T 678
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 545 LG---NAPSSGIEPVF--------------------MHSYIRT-----SEQPALPD------------GINRPPMS---- 580
Cdd:PRK07562 679 IGlvmDCDTTGIEPDFalvkfkklagggyfkiinraVPEALRTlgyseSQIAEIEAyavghgtlnqapGINHSTLKakgf 758
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 581 ------------PNAYEV---------GQDIDADGTAWTAEEQGDETVLRCQEEGHTHWQIHPTRD-IC----------- 627
Cdd:PRK07562 759 tdekiekveaalKSAFDIkfafnkwtlGEDFCKDTLGIPAEQLNDPSFDLLEHLGFSKKDIEAANDhVCgamtlegapfl 838
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 628 KDqevKDYAVrhmetdgtwdpdADWA-----VTTRDLDVDDHLTQMKALAPFVDSSMSKTVNVPNDYPFEDFKELYKKAH 702
Cdd:PRK07562 839 KA---EHLPV------------FDCAnpcgkIGKRYLSVESHIRMMAAAQPFISGAISKTINMPNEATVEDCKNAYMLSW 903
|
570 580 590
....*....|....*....|....*....|...
gi 1425874908 703 DTGvIKGVTTYRAGT-MSAVLSG---EDDGDDD 731
Cdd:PRK07562 904 KLA-LKANALYRDGSkLSQPLNSsliEDDDDDD 935
|
|
| PRK08332 |
PRK08332 |
vitamin B12-dependent ribonucleotide reductase; |
168-377 |
3.44e-13 |
|
vitamin B12-dependent ribonucleotide reductase;
Pssm-ID: 181392 [Multi-domain] Cd Length: 1740 Bit Score: 74.03 E-value: 3.44e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 168 RQAKILASEGGYGFCAHI------MRPRGARIGGVGSMTPGAVQMLDVWNKQAATIVAGSgmksdrddvkdkIRKGAQMV 241
Cdd:PRK08332 739 RYQNYLAGENGMIFVHNTglnfskLRPEGDIVGTTTGAASGPVSFMHLIDAVSDVIKQGG------------VRRGANMG 806
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 242 TMGIWHPDIIEFIEAKQE---PGRLHKFNMSVLITDEFMEAVKNDDTWALRFPdyenekefykqhwdgnlkayqeKGGTV 318
Cdd:PRK08332 807 ILEIWHPDIEKFIHAKEKnigTNVLSNFNISVGIWEDFWEALKEGKKYPLINP----------------------RTGEV 864
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1425874908 319 KTWTDPATgepavyeareIWNRIMDSTYNRNEPGVIFVDTINKENNLGYV--EHINATNPC 377
Cdd:PRK08332 865 VKEIDPKS----------LFEELAYMAWAKADPGVIFFDVINRRNVLKEAkgGPIRATNPC 915
|
|
| PRK09103 |
PRK09103 |
ribonucleoside-diphosphate reductase subunit alpha; |
369-576 |
1.97e-08 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 181649 [Multi-domain] Cd Length: 758 Bit Score: 58.07 E-value: 1.97e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 369 EHINATNpcGEQVLpvggvCLLGNLNVtqlvdreaGTID-YDLVDDLVPLAVRFLDNVNDLSYVPLEEQQRNLQEKRRIG 447
Cdd:PRK09103 447 NDVNDEN--GEIAL-----CTLSAFNL--------GAINsLDELEELADLAVRALDALLDYQDYPIPAAKRGAMGRRTLG 511
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 448 LG-------------HYGDGSALMMmktrygseegarVMREFQehlANQAY--QASARLAEEKGAFPLFDKDEY------ 506
Cdd:PRK09103 512 IGvinfayylakngvRYSDGSANNL------------THKTFE---AIQYYllKASNELAKEQGACPWFNETTYaqgilp 576
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 507 -------LSSPFVQRLS---DKTKEMIGDLGLRNSHLLSIQPTGNTSTLGNApSSGIEPVFMHSYIRTSEqpalpDGINR 576
Cdd:PRK09103 577 idtykkdLDAICNEPLHydwETLREEIKTHGLRNSTLSALMPSETSSQISNA-TNGIEPPRGYVSIKASK-----DGILK 650
|
|
| Ribonuc_red_lgN |
pfam00317 |
Ribonucleotide reductase, all-alpha domain; |
82-137 |
2.16e-06 |
|
Ribonucleotide reductase, all-alpha domain;
Pssm-ID: 459758 [Multi-domain] Cd Length: 75 Bit Score: 46.08 E-value: 2.16e-06
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*...
gi 1425874908 82 RVPDTWYRNARAMAQVE--DDTDMWTQRFYQLLSGKGlgtgpfpFTPGGRIFANAGTG 137
Cdd:pfam00317 25 TPQDMFMRVALALAGAEleEDRLELAEEFYDLLSSLK-------FLPATPTLMNAGTP 75
|
|
| RTPR |
TIGR02505 |
ribonucleoside-triphosphate reductase, adenosylcobalamin-dependent; This model represents a ... |
186-563 |
9.38e-06 |
|
ribonucleoside-triphosphate reductase, adenosylcobalamin-dependent; This model represents a group of adenosylcobalamin(B12)-dependent ribonucleotide reductases (RNR) related to the characterized species from Lactococcus leichmannii. RNR's are responsible for the conversion of the ribose sugar of RNA into the deoxyribose sugar of DNA. This is the rate-limiting step of DNA biosynthesis. Thus model identifies NrdJ enzymes only in cyanobacteria, lactococcus and certain bacteriophage. A separate model (TIGR02504) identifies a larger group of divergent B12-dependent RNR's. [Purines, pyrimidines, nucleosides, and nucleotides, 2'-Deoxyribonucleotide metabolism]
Pssm-ID: 274169 [Multi-domain] Cd Length: 713 Bit Score: 49.53 E-value: 9.38e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 186 MRPRGARIGGVGSMTPGAVQMLDVWNKQAATIVAGSGMKSDRDDVKD------------KIRKGAQMVTMGIWHPDIIEF 253
Cdd:TIGR02505 217 IRPAGAELKGFGGTASGPVPLAKMLTDVAEILSNKAGGRLTAVDAADicnligkavvagNVRRSAEMALFSNDDPEFESF 296
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 254 IEAKQEPGRlHKF--NMSVLITDEFmeavknddtWALrfpdyenekefykqhwdgnlkayqekggtvktwtdpATGEPAV 331
Cdd:TIGR02505 297 KQAKEKLMH-HRWasNNSVAVDSAF---------SGL------------------------------------ARSAADI 330
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 332 YEAREIWNRIMDSTynRNEPGVIfvdtiNKENNLGYVEHINATNPCGEQVLPVGGVCLLGNLNVTQLVDREAGTIdydlv 411
Cdd:TIGR02505 331 LENGEPGQVNLDLS--KSEGRIV-----NGRYQAGEDGDVEGTNPCGEILLANGEPCNLFEVNLLAFEEDGWGLQ----- 398
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 412 dDLVPLAVRFLDNVNdLSYVPLEEQQRNLQEKRRIGLGHYGDGSALMMMktrygseeGARVMREFQEHLANQAYQAsarl 491
Cdd:TIGR02505 399 -RAFALAARYAKRVT-FSPYDDEISREIIQKNRRIGVSMSGIQDFLLLR--------GGTGFKDDFDPETHEAIKV---- 464
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1425874908 492 aeekgafPLFDKdeyLSSPFVQRLSDKT----KEMIGDLGL-RNSHLLSIQPTGNTSTLGNAPsSGIEPVFMHSYIR 563
Cdd:TIGR02505 465 -------RVYDK---RAAKFLDRMYKIVvkaaQDYSKELGCpEPIKHTTVKPSGTISKLAGAS-EGIHPPYGAYLIR 530
|
|
| PRK07219 |
PRK07219 |
DNA topoisomerase I; Validated |
612-698 |
1.43e-03 |
|
DNA topoisomerase I; Validated
Pssm-ID: 235971 [Multi-domain] Cd Length: 822 Bit Score: 42.30 E-value: 1.43e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425874908 612 EEGHTHWQIHPTRDICKDQ------EVKDYAVRHmeTDGTWDPDADWAVTTRDLDVDDHltqmkalaPFvDSSMSKTVN- 684
Cdd:PRK07219 366 KETTDHPPIHPVDVPKREElsddewKVYELIVRR--FLATLADPAEWEYLKVELDVNGE--------IF-KASGSRLVEe 434
|
90
....*....|....*...
gi 1425874908 685 ----VpndYPFEDFKELY 698
Cdd:PRK07219 435 gwheV---YPYEKFDEKE 449
|
|
| |
