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Conserved domains on  [gi|1425910443|ref|WP_112925032|]
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multidrug efflux RND transporter permease subunit MdtC [Escherichia coli]

Protein Classification

multidrug transporter subunit MdtC( domain architecture ID 11484823)

multidrug transporter subunit MdtC is a component of the MdtABC tripartite complex that confers resistance against novobiocin and deoxycholate; MdtABC requires TolC for its function

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PRK10614 PRK10614
multidrug efflux system subunit MdtC; Provisional
1-1025 0e+00

multidrug efflux system subunit MdtC; Provisional


:

Pssm-ID: 182589 [Multi-domain]  Cd Length: 1025  Bit Score: 2083.58  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443    1 MKFFALFIYRPVATILLSVAITLCGILGFRMLPVAPLPQVDFPVIMVSASLPGASPETMASSVATPLERSLGRIAGVSEM 80
Cdd:PRK10614     1 MKFFALFIYRPVATILLSLAITLCGILGFRLLPVAPLPQVDFPVIMVSASLPGASPETMASSVATPLERSLGRIAGVNEM 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443   81 TSSSSLGSTRIILQFDFDRDINGAARDVQAAINAAQSLLPSGMPSRPTYRKANPSDAPIMILTLTSDTYSQGELYDFAST 160
Cdd:PRK10614    81 TSSSSLGSTRIILQFDFDRDINGAARDVQAAINAAQSLLPSGMPSRPTYRKANPSDAPIMILTLTSDTYSQGQLYDFAST 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  161 QLAPTISQIDGVADVDVGGSSLPAVRVGLNPQALFNQGVSLDDVRTAVSNANVRKPQGALEDGTHRWQIQTNDELKTAAE 240
Cdd:PRK10614   161 QLAQTISQIDGVGDVDVGGSSLPAVRVGLNPQALFNQGVSLDDVRQAISNANVRRPQGAVEDGTHRWQIQTNDELKTAAE 240
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  241 YQPLIIHYNNGGAVRLGDVATVTDSVQDVRNAGMTNAKPAILLMIRKLPEANIIQTVDSIRAKLPELQETIPAAIDLQIA 320
Cdd:PRK10614   241 YQPLIIHYNNGAAVRLGDVATVTDSVQDVRNAGMTNAKPAILLMIRKLPEANIIQTVDRIRAKLPELRETIPAAIDLQIA 320
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  321 QDRSPTIRASLEEVEQTLIISVALVILVVFLFLRSGRATIIPAVSVPVSLIGTFAAMYLCGFSLNNLSLMALTIATGFVV 400
Cdd:PRK10614   321 QDRSPTIRASLEEVEQTLAISVALVILVVFLFLRSGRATLIPAVAVPVSLIGTFAAMYLCGFSLNNLSLMALTIATGFVV 400
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  401 DDAIVVLENIARHLEAGMKPLQAALQGTREVGFTVLSMSLSLVAVFLPLLLMGGLPGRLLREFAVTLSVAIGISLLVSLT 480
Cdd:PRK10614   401 DDAIVVLENISRHLEAGMKPLQAALQGVREVGFTVLSMSLSLVAVFLPLLLMGGLPGRLFREFAVTLSVAIGISLLVSLT 480
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  481 LTPMMCGWMLKASKPREQKRLRGFGRMLVALQQGYGKSLKWVLNHTRLVGVVLLGTIALNIWLYISIPKTFFPEQDTGVL 560
Cdd:PRK10614   481 LTPMMCAWLLKSSKPREQKRLRGFGRMLVALQQGYGRSLKWVLNHTRWVGVVLLGTIALNVWLYISIPKTFFPEQDTGRL 560
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  561 MGGIQADQSISFQAMRGKLQDFMKIIRDDPAVDNVTGFTGGSRVNSGMMFITLKPRDERSETAQQIIDRLRVKLAKEPGA 640
Cdd:PRK10614   561 MGFIQADQSISFQAMRGKLQDFMKIIRDDPAVDNVTGFTGGSRVNSGMMFITLKPLSERSETAQQVIDRLRVKLAKEPGA 640
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  641 NLFLMAVQDIRVGGRQSNASYQYTLLSDDLAALREWEPKIRKKLATLPELADVNSDQQDNGAEMNLVYDRDTMARLGIDV 720
Cdd:PRK10614   641 NLFLMAVQDIRVGGRQSNASYQYTLLSDDLAALREWEPKIRKALAALPELADVNSDQQDKGAEMALTYDRDTMARLGIDV 720
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  721 QAANSLLNNAFGQRQISTIYQPMNQYKVVMEVDPRYTQDISALEKMFVINNEGKAIPLSYFAKWQPANAPLSVNHQGLSA 800
Cdd:PRK10614   721 QAANSLLNNAFGQRQISTIYQPLNQYKVVMEVDPRYTQDISALEKMFVINNEGKAIPLSYFAKWQPANAPLSVNHQGLSA 800
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  801 ASTISFNLPTGKSLSDASAAIDRAMTQLGVPSTVRGSFAGTAQVFQETMNSQVILIIAAIATVYIVLGILYESYVHPLTI 880
Cdd:PRK10614   801 ASTISFNLPTGKSLSDASAAIERAMTQLGVPSTVRGSFAGTAQVFQETMNSQLILILAAIATVYIVLGILYESYVHPLTI 880
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  881 LSTLPSAGVGALLALELFNAPFSLIALIGIMLLIGIVKKNAIMMVDFALEAQRHGNLTPQEAIFQACLLRFRPIMMTTLA 960
Cdd:PRK10614   881 LSTLPSAGVGALLALELFNAPFSLIALIGIMLLIGIVKKNAIMMVDFALEAQRNGNLTAQEAIFQACLLRFRPIMMTTLA 960
                          970       980       990      1000      1010      1020
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1425910443  961 ALFGALPLVLSGGDGSELRQPLGITIVGGLVMSQLLTLYTTPVVYLFFDRLRLRFSRKPKQTVTE 1025
Cdd:PRK10614   961 ALFGALPLVLSGGDGAELRQPLGITIVGGLVMSQLLTLYTTPVVYLFFDRLRLRFSRKPKQTVTE 1025
 
Name Accession Description Interval E-value
PRK10614 PRK10614
multidrug efflux system subunit MdtC; Provisional
1-1025 0e+00

multidrug efflux system subunit MdtC; Provisional


Pssm-ID: 182589 [Multi-domain]  Cd Length: 1025  Bit Score: 2083.58  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443    1 MKFFALFIYRPVATILLSVAITLCGILGFRMLPVAPLPQVDFPVIMVSASLPGASPETMASSVATPLERSLGRIAGVSEM 80
Cdd:PRK10614     1 MKFFALFIYRPVATILLSLAITLCGILGFRLLPVAPLPQVDFPVIMVSASLPGASPETMASSVATPLERSLGRIAGVNEM 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443   81 TSSSSLGSTRIILQFDFDRDINGAARDVQAAINAAQSLLPSGMPSRPTYRKANPSDAPIMILTLTSDTYSQGELYDFAST 160
Cdd:PRK10614    81 TSSSSLGSTRIILQFDFDRDINGAARDVQAAINAAQSLLPSGMPSRPTYRKANPSDAPIMILTLTSDTYSQGQLYDFAST 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  161 QLAPTISQIDGVADVDVGGSSLPAVRVGLNPQALFNQGVSLDDVRTAVSNANVRKPQGALEDGTHRWQIQTNDELKTAAE 240
Cdd:PRK10614   161 QLAQTISQIDGVGDVDVGGSSLPAVRVGLNPQALFNQGVSLDDVRQAISNANVRRPQGAVEDGTHRWQIQTNDELKTAAE 240
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  241 YQPLIIHYNNGGAVRLGDVATVTDSVQDVRNAGMTNAKPAILLMIRKLPEANIIQTVDSIRAKLPELQETIPAAIDLQIA 320
Cdd:PRK10614   241 YQPLIIHYNNGAAVRLGDVATVTDSVQDVRNAGMTNAKPAILLMIRKLPEANIIQTVDRIRAKLPELRETIPAAIDLQIA 320
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  321 QDRSPTIRASLEEVEQTLIISVALVILVVFLFLRSGRATIIPAVSVPVSLIGTFAAMYLCGFSLNNLSLMALTIATGFVV 400
Cdd:PRK10614   321 QDRSPTIRASLEEVEQTLAISVALVILVVFLFLRSGRATLIPAVAVPVSLIGTFAAMYLCGFSLNNLSLMALTIATGFVV 400
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  401 DDAIVVLENIARHLEAGMKPLQAALQGTREVGFTVLSMSLSLVAVFLPLLLMGGLPGRLLREFAVTLSVAIGISLLVSLT 480
Cdd:PRK10614   401 DDAIVVLENISRHLEAGMKPLQAALQGVREVGFTVLSMSLSLVAVFLPLLLMGGLPGRLFREFAVTLSVAIGISLLVSLT 480
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  481 LTPMMCGWMLKASKPREQKRLRGFGRMLVALQQGYGKSLKWVLNHTRLVGVVLLGTIALNIWLYISIPKTFFPEQDTGVL 560
Cdd:PRK10614   481 LTPMMCAWLLKSSKPREQKRLRGFGRMLVALQQGYGRSLKWVLNHTRWVGVVLLGTIALNVWLYISIPKTFFPEQDTGRL 560
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  561 MGGIQADQSISFQAMRGKLQDFMKIIRDDPAVDNVTGFTGGSRVNSGMMFITLKPRDERSETAQQIIDRLRVKLAKEPGA 640
Cdd:PRK10614   561 MGFIQADQSISFQAMRGKLQDFMKIIRDDPAVDNVTGFTGGSRVNSGMMFITLKPLSERSETAQQVIDRLRVKLAKEPGA 640
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  641 NLFLMAVQDIRVGGRQSNASYQYTLLSDDLAALREWEPKIRKKLATLPELADVNSDQQDNGAEMNLVYDRDTMARLGIDV 720
Cdd:PRK10614   641 NLFLMAVQDIRVGGRQSNASYQYTLLSDDLAALREWEPKIRKALAALPELADVNSDQQDKGAEMALTYDRDTMARLGIDV 720
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  721 QAANSLLNNAFGQRQISTIYQPMNQYKVVMEVDPRYTQDISALEKMFVINNEGKAIPLSYFAKWQPANAPLSVNHQGLSA 800
Cdd:PRK10614   721 QAANSLLNNAFGQRQISTIYQPLNQYKVVMEVDPRYTQDISALEKMFVINNEGKAIPLSYFAKWQPANAPLSVNHQGLSA 800
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  801 ASTISFNLPTGKSLSDASAAIDRAMTQLGVPSTVRGSFAGTAQVFQETMNSQVILIIAAIATVYIVLGILYESYVHPLTI 880
Cdd:PRK10614   801 ASTISFNLPTGKSLSDASAAIERAMTQLGVPSTVRGSFAGTAQVFQETMNSQLILILAAIATVYIVLGILYESYVHPLTI 880
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  881 LSTLPSAGVGALLALELFNAPFSLIALIGIMLLIGIVKKNAIMMVDFALEAQRHGNLTPQEAIFQACLLRFRPIMMTTLA 960
Cdd:PRK10614   881 LSTLPSAGVGALLALELFNAPFSLIALIGIMLLIGIVKKNAIMMVDFALEAQRNGNLTAQEAIFQACLLRFRPIMMTTLA 960
                          970       980       990      1000      1010      1020
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1425910443  961 ALFGALPLVLSGGDGSELRQPLGITIVGGLVMSQLLTLYTTPVVYLFFDRLRLRFSRKPKQTVTE 1025
Cdd:PRK10614   961 ALFGALPLVLSGGDGAELRQPLGITIVGGLVMSQLLTLYTTPVVYLFFDRLRLRFSRKPKQTVTE 1025
RND_permease_2 NF033617
multidrug efflux RND transporter permease subunit;
4-1010 0e+00

multidrug efflux RND transporter permease subunit;


Pssm-ID: 411236 [Multi-domain]  Cd Length: 1009  Bit Score: 1459.46  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443    4 FALFIYRPVATILLSVAITLCGILGFRMLPVAPLPQVDFPVIMVSASLPGASPETMASSVATPLERSLGRIAGVSEMTSS 83
Cdd:NF033617     1 SDVFIKRPVATLLLSLLILLLGLLAFRKLPVREYPEVDFPTITVSTSYPGASPELMQSSITQPLEQQLAQIEGIDEMTSQ 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443   84 SSLGSTRIILQFDFDRDINGAARDVQAAINAAQSLLPSGMPSRPTYRKANPSDAPIMILTLTSDTYSQGELYDFASTQLA 163
Cdd:NF033617    81 SSLGYSTITLQFRLGTDLDVALSEVQAAINAAQSLLPSEAPDPPVYRKANSADTPIMYIGLTSEEMPRGQLTDYAERVLA 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  164 PTISQIDGVADVDVGGSSLPAVRVGLNPQALFNQGVSLDDVRTAVSNANVRKPQGALEDGTHRWQIQTNDELKTAAEYQP 243
Cdd:NF033617   161 PKLSQINGVGSVDVSGGQRPAMRVWLDPEKMAARGLTADDVRSALNSNNVNSPKGAVRGDSVVSTVRANDQLKTAEDYED 240
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  244 LIIHYN-NGGAVRLGDVATVTDSVQDVRNAGMTNAKPAILLMIRKLPEANIIQTVDSIRAKLPELQETIPAAIDLQIAQD 322
Cdd:NF033617   241 LVIKYAdNGAPVRLGDVATVELGAENVRNRAWANGVPAVVLGINRQPGANPIEVADEIRALLPELQETLPKNIKVNVLYD 320
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  323 RSPTIRASLEEVEQTLIISVALVILVVFLFLRSGRATIIPAVSVPVSLIGTFAAMYLCGFSLNNLSLMALTIATGFVVDD 402
Cdd:NF033617   321 RTRFIRASIDEVESTLLEAVALVILVVFLFLRNLRATLIPAVTVPLSLIGTFAVMYLFGFSINLLTLMALVLAIGLVVDD 400
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  403 AIVVLENIARHLEAGMKPLQAALQGTREVGFTVLSMSLSLVAVFLPLLLMGGLPGRLLREFAVTLSVAIGISLLVSLTLT 482
Cdd:NF033617   401 AIVVVENIHRHIEEGESPLEAALKGAREIGFTVIAMTLTLVAVYLPILFMGGLTGRLFREFAVTLAGAVIISGIVALTLT 480
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  483 PMMCGWMLKASkPREQKRLRGFGRMLVALQQGYGKSLKWVLNHTRLVGVVLLGTIALNIWLYISIPKTFFPEQDTGVLMG 562
Cdd:NF033617   481 PMMCSRLLKAN-EKPGRFARAVDRFFDGLTARYGRGLKWVLKHRPLTLVVALATLALLPLLYVFIPKELAPSEDRGVIFG 559
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  563 GIQADQSISFQAMRGKLQDFMKIIRDDPAVDNVTGFTGGSRVNS---GMMFITLKPRDERSETAQQIIDRLRVKLAKEPG 639
Cdd:NF033617   560 MIQAPQSISLDYMSAKMRDVEKILSSDPEVQSLTSFNGVGGNPGdntGFGIINLKPWDERDVSAQEIIDRLRPKLAKVPG 639
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  640 ANLFLMAVQDIRVGGRQSNASYQYTLLSDDLAALREWEPKIRKKLATLPELADVNSDQQDNGAEMNLVYDRDTMARLGID 719
Cdd:NF033617   640 MDLFLFPLQDLPGGAGSSLPQYQVTLTPSDYDSLFTWAEKLKEKLRKSPQFADVDSDLQDKGPELNVDIDRDKAARLGIS 719
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  720 VQAANSLLNNAFGQRQISTIYQPMNQYKVVMEVDPRYTQDISALEKMFVINNEGKAIPLSYFAKWQPANAPLSVNHQGLS 799
Cdd:NF033617   720 MQDIGSTLEVAFGQRQVNTIYTDGNQYKVVLEVDRRYRLNPEALNQIYVRSNDGKLVPLSTLAKIEERAAPLSLNHFNQF 799
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  800 AASTISFNLPTGKSLSDASAAIDRAMTQLgVPSTVRGSFAGTAQVFQETMNSQVILIIAAIATVYIVLGILYESYVHPLT 879
Cdd:NF033617   800 NSATLSFNLAPGVSLGEAIEALDQAAKEL-LPSGISGSFQGAARAFQEEGSSLLFLFLLALAAIYLVLAIQYESFVDPLT 878
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  880 ILSTLPSAGVGALLALELFNAPFSLIALIGIMLLIGIVKKNAIMMVDFALEAQRHGNLTPQEAIFQACLLRFRPIMMTTL 959
Cdd:NF033617   879 ILSTVPLAGCGALLALALGGQSMNIYAQIGLITLIGLVKKNGILMVEFANELQRHQGLSRREAIYQAAALRLRPILMTTL 958
                          970       980       990      1000      1010
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1425910443  960 AALFGALPLVLSGGDGSELRQPLGITIVGGLVMSQLLTLYTTPVVYLFFDR 1010
Cdd:NF033617   959 AMLLGAIPLMLSTGAGAESRFPLGIVIVGGLGVGTLFTLFVLPVVYLLLAR 1009
ACR_tran pfam00873
AcrB/AcrD/AcrF family; Members of this family are integral membrane proteins. Some are ...
3-1009 0e+00

AcrB/AcrD/AcrF family; Members of this family are integral membrane proteins. Some are involved in drug resistance. AcrB cooperates with a membrane fusion protein, AcrA, and an outer membrane channel TolC. The structure shows the AcrB forms a homotrimer.


Pssm-ID: 395701 [Multi-domain]  Cd Length: 1021  Bit Score: 1240.25  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443    3 FFALFIYRPVATILLSVAITLCGILGFRMLPVAPLPQVDFPVIMVSASLPGASPETMASSVATPLERSLGRIAGVSEMTS 82
Cdd:pfam00873    1 MSKFFIRRPIFTLVLAIAILLAGILSFFSLPVDAFPEIAPPTVQVSTSYPGASPEEVEDTVTQPIEQAMNGLDGLKYMSS 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443   83 SSSLGSTRIILQFDFDRDINGAARDVQAAINAAQSLLPSGMpSRPTYRKANPSDAPIMILTLTSD--TYSQGELYDFAST 160
Cdd:pfam00873   81 QSSYGLSSITLTFELGTDIDIARQDVQNRLQLATPLLPEGV-QRPGISVIKTSLGPIMVLAVTSPdgSYTQTDLRDYADT 159
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  161 QLAPTISQIDGVADVDVGGSSLPAVRVGLNPQALFNQGVSLDDVRTAVSNANVRKPQGALEDGTHRWQIQTNDELKTAAE 240
Cdd:pfam00873  160 NIKPQLSRVPGVGDVQLFGGSEYAMRIWLDPQKLARYGLTLTDVVSALKEQNVNIGAGQLEGQGLQALIRAQGQLQSAED 239
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  241 YQPLIIHYNNGGAVRLGDVATVTDSVQDVRNAGMTNAKPAILLMIRKLPEANIIQTVDSIRAKLPELQETIPAAIDLQIA 320
Cdd:pfam00873  240 FEKIIVKNQDGSPVRLRDVATVELGSELYRGFATFNGKPAVGLGVQKLPGANAIETADAVRAKLAELKPTFPQGVEIVVV 319
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  321 QDRSPTIRASLEEVEQTLIISVALVILVVFLFLRSGRATIIPAVSVPVSLIGTFAAMYLCGFSLNNLSLMALTIATGFVV 400
Cdd:pfam00873  320 YDTTPFIRASIEEVVKTLLEAIVLVILVMFLFLQNWRATLIPAIAIPLSLLGTFAVMKAFGFSINTLTLGGLVLAIGLVV 399
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  401 DDAIVVLENIARHLEA-GMKPLQAALQGTREVGFTVLSMSLSLVAVFLPLLLMGGLPGRLLREFAVTLSVAIGISLLVSL 479
Cdd:pfam00873  400 DDAIVVVENIERVLEEnGLKPLEAAYKSMGEIGGALVAIALVLSAVFLPILFLGGLTGRIFRQFAITIVLAILLSVLVAL 479
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  480 TLTPMMCGWMLKASKPREQKRL-RGFGRMLVALQQGYGKSLKWVLNHTRLVGVVLLGTIALNIWLYISIPKTFFPEQDTG 558
Cdd:pfam00873  480 TLTPALCATLLKPRREPKHGGFfRWFNRMFDRLTRGYAKLLAKVLRHTAVVLLVALLLVVGSVWLFVRIPTEFLPEEDEG 559
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  559 VLMGGIQADQSISFQAMRGKLQDFMKIIRDDPAVDNVTGFTGGS------RVNSGMMFITLKPRDER---SETAQQIIDR 629
Cdd:pfam00873  560 VFVTSAQLPPGVSLDQTQRVMKQVEKILKEKPEVESVFAVTGFAfsgdnnGPNSGDAFISLKPWKERpgpEKSVQALIER 639
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  630 LRVKLAKEPGANLFLMAVQDIRV--GGRQSNASYQYTLLSDDLAALREWEPKIRKKLATLPELADVNSDQQDNGAEMNLV 707
Cdd:pfam00873  640 LRKALKQIPGANVFLFQPIQLRGlgTISGFRSDLQVKIFGDDLDALDEARNQILAALAQLPGLSDVRSDGQEDQPQLQVN 719
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  708 YDRDTMARLGIDVQAANSLLNNAFGQRQISTIYQPMNQYKVVMEVDPRYTQDISALEKMFVINNEGKAIPLSYFAKWQPA 787
Cdd:pfam00873  720 IDREKAARLGVSIQDINDTLSTALGGSYVNDFPEGGRVYDVVVQLPEDFRSSPEDIGQLYVRNPYGKMIPLSAFAKIEWG 799
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  788 NAPLSVNHQGLSAASTISFNLPTGKSLSDASAAIDRAMTQLGVPSTVRGSFAGTAQVFQETMNSQVILIIAAIATVYIVL 867
Cdd:pfam00873  800 YGPPSINRYNGFRSIVISGNVAAGDSLGDAMEAMAQIAKQVKLPPGYGYTWTGQFEQEQLAGNSLPILIALALLVVFLVL 879
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  868 GILYESYVHPLTILSTLPSAGVGALLALELFNAPFSLIALIGIMLLIGIVKKNAIMMVDFALEAQRHGNLTPQEAIFQAC 947
Cdd:pfam00873  880 AALYESWSDPLSIMLTVPLALVGALLALWLRGLPNSVYAQVGLILLIGLAVKNAILMVEFANELREQEGKSLEEAILEAC 959
                          970       980       990      1000      1010      1020
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1425910443  948 LLRFRPIMMTTLAALFGALPLVLSGGDGSELRQPLGITIVGGLVMSQLLTLYTTPVVYLFFD 1009
Cdd:pfam00873  960 RLRLRPILMTALAAILGVLPLALSTGAGSELQQPLGIVVFGGLVTSTVLTLLVVPVFYVLFH 1021
AcrB COG0841
Multidrug efflux pump subunit AcrB [Defense mechanisms];
1-1015 0e+00

Multidrug efflux pump subunit AcrB [Defense mechanisms];


Pssm-ID: 440603 [Multi-domain]  Cd Length: 1015  Bit Score: 1187.60  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443    1 MKFFALFIYRPVATILLSVAITLCGILGFRMLPVAPLPQVDFPVIMVSASLPGASPETMASSVATPLERSLGRIAGVSEM 80
Cdd:COG0841      1 MNLSRFFIRRPVAAIVLSLLILLAGLLAYLRLPVEQFPDIDPPTVTVSTTYPGASPEEVESTVTTPIEEALNGVEGIKYI 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443   81 TSSSSLGSTRIILQFDFDRDINGAARDVQAAINAAQSLLPSGMpSRPTYRKANPSDAPIMILTLTSDTYSQGELYDFAST 160
Cdd:COG0841     81 TSTSSEGSSSITVEFELGTDIDEALVDVQNAVDRARSDLPEDV-EPPGVTKVNPSDFPVMVLALSSDDLDELELSDYAER 159
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  161 QLAPTISQIDGVADVDVGGSSLPAVRVGLNPQALFNQGVSLDDVRTAVSNANVRKPQGALEDGTHRWQIQTNDELKTAAE 240
Cdd:COG0841    160 NIKDRLERVPGVGQVQIFGGREREIRIWLDPDKLAAYGLTLADVANAIRAQNVDVPAGRIGGGDREYTVRTNGRLKTPEE 239
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  241 YQPLIIHYNNGGAVRLGDVATVTDSVQDVRNAGMTNAKPAILLMIRKLPEANIIQTVDSIRAKLPELQETIPAAIDLQIA 320
Cdd:COG0841    240 FENIVIRTNDGSVVRLGDVARVEDGAEDYRSIARLNGKPAVGLAIQKQPGANALEVADAVRAKLEELQASLPEGVELTIV 319
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  321 QDRSPTIRASLEEVEQTLIISVALVILVVFLFLRSGRATIIPAVSVPVSLIGTFAAMYLCGFSLNNLSLMALTIATGFVV 400
Cdd:COG0841    320 YDQSEFIRASIEEVVKTLLEAILLVVLVVFLFLRSWRATLIPAVAIPVSLIGTFAVMYLLGFSLNILTLFALVLAIGIVV 399
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  401 DDAIVVLENIARHLEAGMKPLQAALQGTREVGFTVLSMSLSLVAVFLPLLLMGGLPGRLLREFAVTLSVAIGISLLVSLT 480
Cdd:COG0841    400 DDAIVVVENIERHMEEGLSPLEAAIKGAREVAGAVIASTLTLVAVFLPLAFMGGITGQLFRQFALTVAIALLISLFVALT 479
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  481 LTPMMCGWMLKASKPREQKRL-RGFGRMLVALQQGYGKSLKWVLNHTRLVGVVLLGTIALNIWLYISIPKTFFPEQDTGV 559
Cdd:COG0841    480 LTPALCARLLKPHPKGKKGRFfRAFNRGFDRLTRGYGRLLRWALRHRKLTLLVALALLALSVLLFGRLPTEFFPEEDQGQ 559
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  560 LMGGIQADQSISFQAMRGKLQDFMKIIRDDPAVDNVTGFTG----GSRVNSGMMFITLKPRDERSETAQQIIDRLRVKLA 635
Cdd:COG0841    560 IIVSVQLPPGTSLERTEAVVRQVEEILLEVPEVESVFSVVGfsggGSGSNSGTIFVTLKPWDERDRSADEIIARLREKLA 639
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  636 KEPGANLFLMAVQDirvGGRQSNASYQYTLLSDDLAALREWEPKIRKKLATLPELADVNSDQQDNGAEMNLVYDRDTMAR 715
Cdd:COG0841    640 KIPGARVFVFQPPA---GGLGSGAPIEVQLQGDDLEELAAAAEKLLAALRQIPGLVDVRSDLQLGKPELQLDIDREKAAA 716
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  716 LGIDVQAANSLLNNAFGQRQISTIYQPMNQYKVVMEVDPRYTQDISALEKMFVINNEGKAIPLSYFAKWQPANAPLSVNH 795
Cdd:COG0841    717 LGVTVADVASTLRAALGGRYVNDFNRGGREYDVRVQAPEEDRNSPEDLENLYVRTPDGEMVPLSSVATIEEGTGPSSINR 796
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  796 QGLSAASTISFNLPTGKSLSDASAAIDRAMTQLGVPSTVRGSFAGTAQVFQETMNSQVILIIAAIATVYIVLGILYESYV 875
Cdd:COG0841    797 YNGQRSVTVSANLAPGVSLGEALAAIEELAAELKLPPGVSIEFTGQAEEEQESFSSLGLAFLLALLLVYLVLAAQFESFI 876
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  876 HPLTILSTLPSAGVGALLALELFNAPFSLIALIGIMLLIGIVKKNAIMMVDFALEAQRHGnLTPQEAIFQACLLRFRPIM 955
Cdd:COG0841    877 QPLIILLTVPLALIGALLGLLLTGTPLNIYSQIGLIMLIGIVVKNAILLVDFANQLREEG-MSLREAILEAARLRLRPIL 955
                          970       980       990      1000      1010      1020
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  956 MTTLAALFGALPLVLSGGDGSELRQPLGITIVGGLVMSQLLTLYTTPVVYLFFDRLRLRF 1015
Cdd:COG0841    956 MTSLATILGLLPLALGTGAGAEFRQPLGIAVIGGLLFSTLLTLFVVPVLYVLLDRLRRRL 1015
2A0602 TIGR00915
The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Proteins ...
7-1025 1.05e-171

The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Proteins scoring above the trusted cutoff (1000) form a tight clade within the RND (Resistance-Nodulation-Cell Division) superfamily. Proteins scoring greater than the noise cutoff (100) appear to form a larger clade, cleanly separated from more distant homologs that include cadmium/zinc/cobalt resistance transporters. This family is one of several subfamilies within the scope of pfam00873. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Unknown substrate]


Pssm-ID: 273335 [Multi-domain]  Cd Length: 1044  Bit Score: 530.07  E-value: 1.05e-171
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443    7 FIYRPVATILLSVAITLCGILGFRMLPVAPLPQVDFPVIMVSASLPGASPETMASSVATPLERSLGRIAGVSEMTSSS-S 85
Cdd:TIGR00915    5 FIDRPIFAWVIAIIIMLAGTLSILSLPVSQYPSIAPPAITVSASYPGASAQTVQDTVTQVIEQNMNGIDGLRYMSSSSdS 84
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443   86 LGSTRIILQFDFDRDINGAARDVQAAINAAQSLLPSGMpSRPTYRKANPSDAPIMILTLTSD--TYSQGELYDFASTQLA 163
Cdd:TIGR00915   85 DGSMTITLTFEQGTDPDIAQVQVQNKLQLATPLLPQEV-QRQGVRVEKASSNFLMVIGLVSDdgSMTKEDLSDYAASNMV 163
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  164 PTISQIDGVADVDVGGSsLPAVRVGLNPQALFNQGVSLDDVRTAVSNANVRKPQG------ALEDGTHRWQIQTNDELKT 237
Cdd:TIGR00915  164 DPLSRLEGVGDVQLFGS-QYAMRIWLDPAKLNSYQLTPADVISAISAQNAQISAGqlgglpAVPGQQLNATIIAQTRLQT 242
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  238 AAEYQPLIIHYN-NGGAVRLGDVATVTDSVQDVRNAGMTNAKPAILLMIRKLPEANIIQTVDSIRAKLPELQETIPAAID 316
Cdd:TIGR00915  243 PEQFENILLKVNtDGSQVRLKDVARVELGGENYSISARFNGKPASGLAIKLATGANALDTAKAVKAELAVLEPFFPQGMK 322
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  317 LQIAQDRSPTIRASLEEVEQTLIISVALVILVVFLFLRSGRATIIPAVSVPVSLIGTFAAMYLCGFSLNNLSLMALTIAT 396
Cdd:TIGR00915  323 YVYPYDTTPFVEASIEEVVHTLIEAIVLVFLVMYLFLQNFRATLIPTIAVPVVLLGTFAVLAAFGFSINTLTMFAMVLAI 402
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  397 GFVVDDAIVVLENIARHL-EAGMKPLQAALQGTREVGFTVLSMSLSLVAVFLPLLLMGGLPGRLLREFAVTLSVAIGISL 475
Cdd:TIGR00915  403 GLLVDDAIVVVENVERVMaEEGLPPKEATRKSMGQIQGALVGIAMVLSAVFVPMAFFGGSTGAIYRQFSITIVSAMALSV 482
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  476 LVSLTLTPMMCGWMLKASKPREQKRLRG-----FGRMLVALQQGYGKSLKWVLNHTRLVGVVLLGTIALNIWLYISIPKT 550
Cdd:TIGR00915  483 LVALILTPALCATMLKPIEKGEHHEKKGgffgwFNRMFDSSTHGYENGVGKILRRRGRYLLVYVLLVGGMVFLFVRLPTS 562
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  551 FFPEQDTGVLMGGIQADQSISFQAMRGKLQDFMKIIRDDPA-----VDNVTGFT-GGSRVNSGMMFITLKPRDERS---E 621
Cdd:TIGR00915  563 FLPDEDQGVFMTIVQLPAGATAERTQAVLAQVTKYLLAKEKanvesVFTVNGFSfAGRGQNMGMAFIRLKDWEERTgkeN 642
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  622 TAQQIIDRLRVKLAKEPGANLFLMAVQDIRVGGRQSNASYQytlLSD----DLAALREWEPKIRKKLATLPELADVNSDQ 697
Cdd:TIGR00915  643 SVFAIAGRATGHFMQIKDAMVIAFVPPAILELGNATGFDFF---LQDraglGHEALLQARNQLLGLAAQNPALTRVRPNG 719
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  698 QDNGAEMNLVYDRDTMARLGIDVQAANSLLNNAFGQRQISTIYQPMNQYKVVMEVDPRYTQDISALEKMFVINNEGKAIP 777
Cdd:TIGR00915  720 LEDEPQLKIDIDREKAQALGVSIADINTTLSTAWGSSYVNDFIDRGRVKRVYVQAEEDARMSPEDINKWYVRNASGEMVP 799
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  778 LSYFA--KWQpANAPLSVNHQGLSAAStISFNLPTGKSLSDASAAIDRAMTQLgvPSTVrgSFAGTAQVFQETMN-SQVI 854
Cdd:TIGR00915  800 FSAFAtvRWE-YGSPQLERYNGLPSME-ILGSAAPGVSTGQAMAAMEAIAQKL--PPGF--GFSWTGMSYEERLSgSQAP 873
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  855 LIIA-AIATVYIVLGILYESYVHPLTILSTLPSAGVGALLALELFNAPFSLIALIGIMLLIGIVKKNAIMMVDFALEAQR 933
Cdd:TIGR00915  874 ALYAlSLLVVFLCLAALYESWSIPVSVMLVVPLGIIGALLATTLRGLSNDVYFQVGLLTTIGLSAKNAILIVEFAKELMA 953
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  934 HGNlTPQEAIFQACLLRFRPIMMTTLAALFGALPLVLSGGDGSELRQPLGITIVGGLVMSQLLTLYTTPVVYLFFDRLRL 1013
Cdd:TIGR00915  954 QGK-SIVEAALEAARLRLRPILMTSLAFILGVVPLAISTGAGSGSQHAIGTGVFGGMVTATVLAIFFVPLFYVVVRRLFK 1032
                         1050
                   ....*....|..
gi 1425910443 1014 RFSRKPKQTVTE 1025
Cdd:TIGR00915 1033 RKAHEKEMSVEH 1044
 
Name Accession Description Interval E-value
PRK10614 PRK10614
multidrug efflux system subunit MdtC; Provisional
1-1025 0e+00

multidrug efflux system subunit MdtC; Provisional


Pssm-ID: 182589 [Multi-domain]  Cd Length: 1025  Bit Score: 2083.58  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443    1 MKFFALFIYRPVATILLSVAITLCGILGFRMLPVAPLPQVDFPVIMVSASLPGASPETMASSVATPLERSLGRIAGVSEM 80
Cdd:PRK10614     1 MKFFALFIYRPVATILLSLAITLCGILGFRLLPVAPLPQVDFPVIMVSASLPGASPETMASSVATPLERSLGRIAGVNEM 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443   81 TSSSSLGSTRIILQFDFDRDINGAARDVQAAINAAQSLLPSGMPSRPTYRKANPSDAPIMILTLTSDTYSQGELYDFAST 160
Cdd:PRK10614    81 TSSSSLGSTRIILQFDFDRDINGAARDVQAAINAAQSLLPSGMPSRPTYRKANPSDAPIMILTLTSDTYSQGQLYDFAST 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  161 QLAPTISQIDGVADVDVGGSSLPAVRVGLNPQALFNQGVSLDDVRTAVSNANVRKPQGALEDGTHRWQIQTNDELKTAAE 240
Cdd:PRK10614   161 QLAQTISQIDGVGDVDVGGSSLPAVRVGLNPQALFNQGVSLDDVRQAISNANVRRPQGAVEDGTHRWQIQTNDELKTAAE 240
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  241 YQPLIIHYNNGGAVRLGDVATVTDSVQDVRNAGMTNAKPAILLMIRKLPEANIIQTVDSIRAKLPELQETIPAAIDLQIA 320
Cdd:PRK10614   241 YQPLIIHYNNGAAVRLGDVATVTDSVQDVRNAGMTNAKPAILLMIRKLPEANIIQTVDRIRAKLPELRETIPAAIDLQIA 320
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  321 QDRSPTIRASLEEVEQTLIISVALVILVVFLFLRSGRATIIPAVSVPVSLIGTFAAMYLCGFSLNNLSLMALTIATGFVV 400
Cdd:PRK10614   321 QDRSPTIRASLEEVEQTLAISVALVILVVFLFLRSGRATLIPAVAVPVSLIGTFAAMYLCGFSLNNLSLMALTIATGFVV 400
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  401 DDAIVVLENIARHLEAGMKPLQAALQGTREVGFTVLSMSLSLVAVFLPLLLMGGLPGRLLREFAVTLSVAIGISLLVSLT 480
Cdd:PRK10614   401 DDAIVVLENISRHLEAGMKPLQAALQGVREVGFTVLSMSLSLVAVFLPLLLMGGLPGRLFREFAVTLSVAIGISLLVSLT 480
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  481 LTPMMCGWMLKASKPREQKRLRGFGRMLVALQQGYGKSLKWVLNHTRLVGVVLLGTIALNIWLYISIPKTFFPEQDTGVL 560
Cdd:PRK10614   481 LTPMMCAWLLKSSKPREQKRLRGFGRMLVALQQGYGRSLKWVLNHTRWVGVVLLGTIALNVWLYISIPKTFFPEQDTGRL 560
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  561 MGGIQADQSISFQAMRGKLQDFMKIIRDDPAVDNVTGFTGGSRVNSGMMFITLKPRDERSETAQQIIDRLRVKLAKEPGA 640
Cdd:PRK10614   561 MGFIQADQSISFQAMRGKLQDFMKIIRDDPAVDNVTGFTGGSRVNSGMMFITLKPLSERSETAQQVIDRLRVKLAKEPGA 640
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  641 NLFLMAVQDIRVGGRQSNASYQYTLLSDDLAALREWEPKIRKKLATLPELADVNSDQQDNGAEMNLVYDRDTMARLGIDV 720
Cdd:PRK10614   641 NLFLMAVQDIRVGGRQSNASYQYTLLSDDLAALREWEPKIRKALAALPELADVNSDQQDKGAEMALTYDRDTMARLGIDV 720
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  721 QAANSLLNNAFGQRQISTIYQPMNQYKVVMEVDPRYTQDISALEKMFVINNEGKAIPLSYFAKWQPANAPLSVNHQGLSA 800
Cdd:PRK10614   721 QAANSLLNNAFGQRQISTIYQPLNQYKVVMEVDPRYTQDISALEKMFVINNEGKAIPLSYFAKWQPANAPLSVNHQGLSA 800
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  801 ASTISFNLPTGKSLSDASAAIDRAMTQLGVPSTVRGSFAGTAQVFQETMNSQVILIIAAIATVYIVLGILYESYVHPLTI 880
Cdd:PRK10614   801 ASTISFNLPTGKSLSDASAAIERAMTQLGVPSTVRGSFAGTAQVFQETMNSQLILILAAIATVYIVLGILYESYVHPLTI 880
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  881 LSTLPSAGVGALLALELFNAPFSLIALIGIMLLIGIVKKNAIMMVDFALEAQRHGNLTPQEAIFQACLLRFRPIMMTTLA 960
Cdd:PRK10614   881 LSTLPSAGVGALLALELFNAPFSLIALIGIMLLIGIVKKNAIMMVDFALEAQRNGNLTAQEAIFQACLLRFRPIMMTTLA 960
                          970       980       990      1000      1010      1020
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1425910443  961 ALFGALPLVLSGGDGSELRQPLGITIVGGLVMSQLLTLYTTPVVYLFFDRLRLRFSRKPKQTVTE 1025
Cdd:PRK10614   961 ALFGALPLVLSGGDGAELRQPLGITIVGGLVMSQLLTLYTTPVVYLFFDRLRLRFSRKPKQTVTE 1025
RND_permease_2 NF033617
multidrug efflux RND transporter permease subunit;
4-1010 0e+00

multidrug efflux RND transporter permease subunit;


Pssm-ID: 411236 [Multi-domain]  Cd Length: 1009  Bit Score: 1459.46  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443    4 FALFIYRPVATILLSVAITLCGILGFRMLPVAPLPQVDFPVIMVSASLPGASPETMASSVATPLERSLGRIAGVSEMTSS 83
Cdd:NF033617     1 SDVFIKRPVATLLLSLLILLLGLLAFRKLPVREYPEVDFPTITVSTSYPGASPELMQSSITQPLEQQLAQIEGIDEMTSQ 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443   84 SSLGSTRIILQFDFDRDINGAARDVQAAINAAQSLLPSGMPSRPTYRKANPSDAPIMILTLTSDTYSQGELYDFASTQLA 163
Cdd:NF033617    81 SSLGYSTITLQFRLGTDLDVALSEVQAAINAAQSLLPSEAPDPPVYRKANSADTPIMYIGLTSEEMPRGQLTDYAERVLA 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  164 PTISQIDGVADVDVGGSSLPAVRVGLNPQALFNQGVSLDDVRTAVSNANVRKPQGALEDGTHRWQIQTNDELKTAAEYQP 243
Cdd:NF033617   161 PKLSQINGVGSVDVSGGQRPAMRVWLDPEKMAARGLTADDVRSALNSNNVNSPKGAVRGDSVVSTVRANDQLKTAEDYED 240
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  244 LIIHYN-NGGAVRLGDVATVTDSVQDVRNAGMTNAKPAILLMIRKLPEANIIQTVDSIRAKLPELQETIPAAIDLQIAQD 322
Cdd:NF033617   241 LVIKYAdNGAPVRLGDVATVELGAENVRNRAWANGVPAVVLGINRQPGANPIEVADEIRALLPELQETLPKNIKVNVLYD 320
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  323 RSPTIRASLEEVEQTLIISVALVILVVFLFLRSGRATIIPAVSVPVSLIGTFAAMYLCGFSLNNLSLMALTIATGFVVDD 402
Cdd:NF033617   321 RTRFIRASIDEVESTLLEAVALVILVVFLFLRNLRATLIPAVTVPLSLIGTFAVMYLFGFSINLLTLMALVLAIGLVVDD 400
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  403 AIVVLENIARHLEAGMKPLQAALQGTREVGFTVLSMSLSLVAVFLPLLLMGGLPGRLLREFAVTLSVAIGISLLVSLTLT 482
Cdd:NF033617   401 AIVVVENIHRHIEEGESPLEAALKGAREIGFTVIAMTLTLVAVYLPILFMGGLTGRLFREFAVTLAGAVIISGIVALTLT 480
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  483 PMMCGWMLKASkPREQKRLRGFGRMLVALQQGYGKSLKWVLNHTRLVGVVLLGTIALNIWLYISIPKTFFPEQDTGVLMG 562
Cdd:NF033617   481 PMMCSRLLKAN-EKPGRFARAVDRFFDGLTARYGRGLKWVLKHRPLTLVVALATLALLPLLYVFIPKELAPSEDRGVIFG 559
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  563 GIQADQSISFQAMRGKLQDFMKIIRDDPAVDNVTGFTGGSRVNS---GMMFITLKPRDERSETAQQIIDRLRVKLAKEPG 639
Cdd:NF033617   560 MIQAPQSISLDYMSAKMRDVEKILSSDPEVQSLTSFNGVGGNPGdntGFGIINLKPWDERDVSAQEIIDRLRPKLAKVPG 639
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  640 ANLFLMAVQDIRVGGRQSNASYQYTLLSDDLAALREWEPKIRKKLATLPELADVNSDQQDNGAEMNLVYDRDTMARLGID 719
Cdd:NF033617   640 MDLFLFPLQDLPGGAGSSLPQYQVTLTPSDYDSLFTWAEKLKEKLRKSPQFADVDSDLQDKGPELNVDIDRDKAARLGIS 719
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  720 VQAANSLLNNAFGQRQISTIYQPMNQYKVVMEVDPRYTQDISALEKMFVINNEGKAIPLSYFAKWQPANAPLSVNHQGLS 799
Cdd:NF033617   720 MQDIGSTLEVAFGQRQVNTIYTDGNQYKVVLEVDRRYRLNPEALNQIYVRSNDGKLVPLSTLAKIEERAAPLSLNHFNQF 799
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  800 AASTISFNLPTGKSLSDASAAIDRAMTQLgVPSTVRGSFAGTAQVFQETMNSQVILIIAAIATVYIVLGILYESYVHPLT 879
Cdd:NF033617   800 NSATLSFNLAPGVSLGEAIEALDQAAKEL-LPSGISGSFQGAARAFQEEGSSLLFLFLLALAAIYLVLAIQYESFVDPLT 878
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  880 ILSTLPSAGVGALLALELFNAPFSLIALIGIMLLIGIVKKNAIMMVDFALEAQRHGNLTPQEAIFQACLLRFRPIMMTTL 959
Cdd:NF033617   879 ILSTVPLAGCGALLALALGGQSMNIYAQIGLITLIGLVKKNGILMVEFANELQRHQGLSRREAIYQAAALRLRPILMTTL 958
                          970       980       990      1000      1010
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1425910443  960 AALFGALPLVLSGGDGSELRQPLGITIVGGLVMSQLLTLYTTPVVYLFFDR 1010
Cdd:NF033617   959 AMLLGAIPLMLSTGAGAESRFPLGIVIVGGLGVGTLFTLFVLPVVYLLLAR 1009
ACR_tran pfam00873
AcrB/AcrD/AcrF family; Members of this family are integral membrane proteins. Some are ...
3-1009 0e+00

AcrB/AcrD/AcrF family; Members of this family are integral membrane proteins. Some are involved in drug resistance. AcrB cooperates with a membrane fusion protein, AcrA, and an outer membrane channel TolC. The structure shows the AcrB forms a homotrimer.


Pssm-ID: 395701 [Multi-domain]  Cd Length: 1021  Bit Score: 1240.25  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443    3 FFALFIYRPVATILLSVAITLCGILGFRMLPVAPLPQVDFPVIMVSASLPGASPETMASSVATPLERSLGRIAGVSEMTS 82
Cdd:pfam00873    1 MSKFFIRRPIFTLVLAIAILLAGILSFFSLPVDAFPEIAPPTVQVSTSYPGASPEEVEDTVTQPIEQAMNGLDGLKYMSS 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443   83 SSSLGSTRIILQFDFDRDINGAARDVQAAINAAQSLLPSGMpSRPTYRKANPSDAPIMILTLTSD--TYSQGELYDFAST 160
Cdd:pfam00873   81 QSSYGLSSITLTFELGTDIDIARQDVQNRLQLATPLLPEGV-QRPGISVIKTSLGPIMVLAVTSPdgSYTQTDLRDYADT 159
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  161 QLAPTISQIDGVADVDVGGSSLPAVRVGLNPQALFNQGVSLDDVRTAVSNANVRKPQGALEDGTHRWQIQTNDELKTAAE 240
Cdd:pfam00873  160 NIKPQLSRVPGVGDVQLFGGSEYAMRIWLDPQKLARYGLTLTDVVSALKEQNVNIGAGQLEGQGLQALIRAQGQLQSAED 239
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  241 YQPLIIHYNNGGAVRLGDVATVTDSVQDVRNAGMTNAKPAILLMIRKLPEANIIQTVDSIRAKLPELQETIPAAIDLQIA 320
Cdd:pfam00873  240 FEKIIVKNQDGSPVRLRDVATVELGSELYRGFATFNGKPAVGLGVQKLPGANAIETADAVRAKLAELKPTFPQGVEIVVV 319
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  321 QDRSPTIRASLEEVEQTLIISVALVILVVFLFLRSGRATIIPAVSVPVSLIGTFAAMYLCGFSLNNLSLMALTIATGFVV 400
Cdd:pfam00873  320 YDTTPFIRASIEEVVKTLLEAIVLVILVMFLFLQNWRATLIPAIAIPLSLLGTFAVMKAFGFSINTLTLGGLVLAIGLVV 399
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  401 DDAIVVLENIARHLEA-GMKPLQAALQGTREVGFTVLSMSLSLVAVFLPLLLMGGLPGRLLREFAVTLSVAIGISLLVSL 479
Cdd:pfam00873  400 DDAIVVVENIERVLEEnGLKPLEAAYKSMGEIGGALVAIALVLSAVFLPILFLGGLTGRIFRQFAITIVLAILLSVLVAL 479
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  480 TLTPMMCGWMLKASKPREQKRL-RGFGRMLVALQQGYGKSLKWVLNHTRLVGVVLLGTIALNIWLYISIPKTFFPEQDTG 558
Cdd:pfam00873  480 TLTPALCATLLKPRREPKHGGFfRWFNRMFDRLTRGYAKLLAKVLRHTAVVLLVALLLVVGSVWLFVRIPTEFLPEEDEG 559
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  559 VLMGGIQADQSISFQAMRGKLQDFMKIIRDDPAVDNVTGFTGGS------RVNSGMMFITLKPRDER---SETAQQIIDR 629
Cdd:pfam00873  560 VFVTSAQLPPGVSLDQTQRVMKQVEKILKEKPEVESVFAVTGFAfsgdnnGPNSGDAFISLKPWKERpgpEKSVQALIER 639
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  630 LRVKLAKEPGANLFLMAVQDIRV--GGRQSNASYQYTLLSDDLAALREWEPKIRKKLATLPELADVNSDQQDNGAEMNLV 707
Cdd:pfam00873  640 LRKALKQIPGANVFLFQPIQLRGlgTISGFRSDLQVKIFGDDLDALDEARNQILAALAQLPGLSDVRSDGQEDQPQLQVN 719
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  708 YDRDTMARLGIDVQAANSLLNNAFGQRQISTIYQPMNQYKVVMEVDPRYTQDISALEKMFVINNEGKAIPLSYFAKWQPA 787
Cdd:pfam00873  720 IDREKAARLGVSIQDINDTLSTALGGSYVNDFPEGGRVYDVVVQLPEDFRSSPEDIGQLYVRNPYGKMIPLSAFAKIEWG 799
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  788 NAPLSVNHQGLSAASTISFNLPTGKSLSDASAAIDRAMTQLGVPSTVRGSFAGTAQVFQETMNSQVILIIAAIATVYIVL 867
Cdd:pfam00873  800 YGPPSINRYNGFRSIVISGNVAAGDSLGDAMEAMAQIAKQVKLPPGYGYTWTGQFEQEQLAGNSLPILIALALLVVFLVL 879
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  868 GILYESYVHPLTILSTLPSAGVGALLALELFNAPFSLIALIGIMLLIGIVKKNAIMMVDFALEAQRHGNLTPQEAIFQAC 947
Cdd:pfam00873  880 AALYESWSDPLSIMLTVPLALVGALLALWLRGLPNSVYAQVGLILLIGLAVKNAILMVEFANELREQEGKSLEEAILEAC 959
                          970       980       990      1000      1010      1020
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1425910443  948 LLRFRPIMMTTLAALFGALPLVLSGGDGSELRQPLGITIVGGLVMSQLLTLYTTPVVYLFFD 1009
Cdd:pfam00873  960 RLRLRPILMTALAAILGVLPLALSTGAGSELQQPLGIVVFGGLVTSTVLTLLVVPVFYVLFH 1021
AcrB COG0841
Multidrug efflux pump subunit AcrB [Defense mechanisms];
1-1015 0e+00

Multidrug efflux pump subunit AcrB [Defense mechanisms];


Pssm-ID: 440603 [Multi-domain]  Cd Length: 1015  Bit Score: 1187.60  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443    1 MKFFALFIYRPVATILLSVAITLCGILGFRMLPVAPLPQVDFPVIMVSASLPGASPETMASSVATPLERSLGRIAGVSEM 80
Cdd:COG0841      1 MNLSRFFIRRPVAAIVLSLLILLAGLLAYLRLPVEQFPDIDPPTVTVSTTYPGASPEEVESTVTTPIEEALNGVEGIKYI 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443   81 TSSSSLGSTRIILQFDFDRDINGAARDVQAAINAAQSLLPSGMpSRPTYRKANPSDAPIMILTLTSDTYSQGELYDFAST 160
Cdd:COG0841     81 TSTSSEGSSSITVEFELGTDIDEALVDVQNAVDRARSDLPEDV-EPPGVTKVNPSDFPVMVLALSSDDLDELELSDYAER 159
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  161 QLAPTISQIDGVADVDVGGSSLPAVRVGLNPQALFNQGVSLDDVRTAVSNANVRKPQGALEDGTHRWQIQTNDELKTAAE 240
Cdd:COG0841    160 NIKDRLERVPGVGQVQIFGGREREIRIWLDPDKLAAYGLTLADVANAIRAQNVDVPAGRIGGGDREYTVRTNGRLKTPEE 239
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  241 YQPLIIHYNNGGAVRLGDVATVTDSVQDVRNAGMTNAKPAILLMIRKLPEANIIQTVDSIRAKLPELQETIPAAIDLQIA 320
Cdd:COG0841    240 FENIVIRTNDGSVVRLGDVARVEDGAEDYRSIARLNGKPAVGLAIQKQPGANALEVADAVRAKLEELQASLPEGVELTIV 319
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  321 QDRSPTIRASLEEVEQTLIISVALVILVVFLFLRSGRATIIPAVSVPVSLIGTFAAMYLCGFSLNNLSLMALTIATGFVV 400
Cdd:COG0841    320 YDQSEFIRASIEEVVKTLLEAILLVVLVVFLFLRSWRATLIPAVAIPVSLIGTFAVMYLLGFSLNILTLFALVLAIGIVV 399
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  401 DDAIVVLENIARHLEAGMKPLQAALQGTREVGFTVLSMSLSLVAVFLPLLLMGGLPGRLLREFAVTLSVAIGISLLVSLT 480
Cdd:COG0841    400 DDAIVVVENIERHMEEGLSPLEAAIKGAREVAGAVIASTLTLVAVFLPLAFMGGITGQLFRQFALTVAIALLISLFVALT 479
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  481 LTPMMCGWMLKASKPREQKRL-RGFGRMLVALQQGYGKSLKWVLNHTRLVGVVLLGTIALNIWLYISIPKTFFPEQDTGV 559
Cdd:COG0841    480 LTPALCARLLKPHPKGKKGRFfRAFNRGFDRLTRGYGRLLRWALRHRKLTLLVALALLALSVLLFGRLPTEFFPEEDQGQ 559
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  560 LMGGIQADQSISFQAMRGKLQDFMKIIRDDPAVDNVTGFTG----GSRVNSGMMFITLKPRDERSETAQQIIDRLRVKLA 635
Cdd:COG0841    560 IIVSVQLPPGTSLERTEAVVRQVEEILLEVPEVESVFSVVGfsggGSGSNSGTIFVTLKPWDERDRSADEIIARLREKLA 639
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  636 KEPGANLFLMAVQDirvGGRQSNASYQYTLLSDDLAALREWEPKIRKKLATLPELADVNSDQQDNGAEMNLVYDRDTMAR 715
Cdd:COG0841    640 KIPGARVFVFQPPA---GGLGSGAPIEVQLQGDDLEELAAAAEKLLAALRQIPGLVDVRSDLQLGKPELQLDIDREKAAA 716
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  716 LGIDVQAANSLLNNAFGQRQISTIYQPMNQYKVVMEVDPRYTQDISALEKMFVINNEGKAIPLSYFAKWQPANAPLSVNH 795
Cdd:COG0841    717 LGVTVADVASTLRAALGGRYVNDFNRGGREYDVRVQAPEEDRNSPEDLENLYVRTPDGEMVPLSSVATIEEGTGPSSINR 796
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  796 QGLSAASTISFNLPTGKSLSDASAAIDRAMTQLGVPSTVRGSFAGTAQVFQETMNSQVILIIAAIATVYIVLGILYESYV 875
Cdd:COG0841    797 YNGQRSVTVSANLAPGVSLGEALAAIEELAAELKLPPGVSIEFTGQAEEEQESFSSLGLAFLLALLLVYLVLAAQFESFI 876
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  876 HPLTILSTLPSAGVGALLALELFNAPFSLIALIGIMLLIGIVKKNAIMMVDFALEAQRHGnLTPQEAIFQACLLRFRPIM 955
Cdd:COG0841    877 QPLIILLTVPLALIGALLGLLLTGTPLNIYSQIGLIMLIGIVVKNAILLVDFANQLREEG-MSLREAILEAARLRLRPIL 955
                          970       980       990      1000      1010      1020
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  956 MTTLAALFGALPLVLSGGDGSELRQPLGITIVGGLVMSQLLTLYTTPVVYLFFDRLRLRF 1015
Cdd:COG0841    956 MTSLATILGLLPLALGTGAGAEFRQPLGIAVIGGLLFSTLLTLFVVPVLYVLLDRLRRRL 1015
PRK10503 PRK10503
MdtB/MuxB family multidrug efflux RND transporter permease subunit;
6-1025 0e+00

MdtB/MuxB family multidrug efflux RND transporter permease subunit;


Pssm-ID: 182501 [Multi-domain]  Cd Length: 1040  Bit Score: 1087.07  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443    6 LFIYRPVATILLSVAITLCGILGFRMLPVAPLPQVDFPVIMVSASLPGASPETMASSVATPLERSLGRIAGVSEMTSSSS 85
Cdd:PRK10503    15 LFILRPVATTLLMVAILLAGIIGYRALPVSALPEVDYPTIQVVTLYPGASPDVMTSAVTAPLERQFGQMSGLKQMSSQSS 94
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443   86 LGSTRIILQFDFDRDINGAARDVQAAINAAQSLLPSGMPSRPTYRKANPSDAPIMILTLTSDTYSQGELYDFASTQLAPT 165
Cdd:PRK10503    95 GGASVITLQFQLTLPLDVAEQEVQAAINAATNLLPSDLPNPPVYSKVNPADPPIMTLAVTSTAMPMTQVEDMVETRVAQK 174
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  166 ISQIDGVADVDVGGSSLPAVRVGLNPQALFNQGVSLDDVRTAVSNANVRKPQGALEDGTHRWQIQTNDELKTAAEYQPLI 245
Cdd:PRK10503   175 ISQVSGVGLVTLSGGQRPAVRVKLNAQAIAALGLTSETVRTAITGANVNSAKGSLDGPTRAVTLSANDQMQSAEEYRQLI 254
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  246 IHYNNGGAVRLGDVATVTDSVQDVRNAGMTNAKPAILLMIRKLPEANIIQTVDSIRAKLPELQETIPAAIDLQIAQDRSP 325
Cdd:PRK10503   255 IAYQNGAPIRLGDVATVEQGAENSWLGAWANKQQAIVMNVQRQPGANIIATADSIRQMLPQLTESLPKSVKVTVLSDRTT 334
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  326 TIRASLEEVEQTLIISVALVILVVFLFLRSGRATIIPAVSVPVSLIGTFAAMYLCGFSLNNLSLMALTIATGFVVDDAIV 405
Cdd:PRK10503   335 NIRASVDDTQFELMLAIALVVMIIYLFLRNIPATIIPGVAVPLSLIGTFAVMVFLDFSINNLTLMALTIATGFVVDDAIV 414
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  406 VLENIARHLEAGMKPLQAALQGTREVGFTVLSMSLSLVAVFLPLLLMGGLPGRLLREFAVTLSVAIGISLLVSLTLTPMM 485
Cdd:PRK10503   415 VIENISRYIEKGEKPLAAALKGAGEIGFTIISLTFSLIAVLIPLLFMGDIVGRLFREFAVTLAVAILISAVVSLTLTPMM 494
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  486 CGWMLKASKPREQKRL-RGFGRMLVALQQGYGKSLKWVLNHTRLVGVVLLGTIALNIWLYISIPKTFFPEQDTGVLMGGI 564
Cdd:PRK10503   495 CARMLSQESLRKQNRFsRASERMFDRVIAAYGRGLAKVLNHPWLTLSVALSTLLLTVLLWIFIPKGFFPVQDNGIIQGTL 574
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  565 QADQSISFQAMRGKLQDFMKIIRDDPAVDNVTGFTG----GSRVNSGMMFITLKPRDERSETAQQIIDRLRVKLAKEPGA 640
Cdd:PRK10503   575 QAPQSSSFANMAQRQRQVADVILQDPAVQSLTSFVGvdgtNPSLNSARLQINLKPLDERDDRVQKVIARLQTAVAKVPGV 654
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  641 NLFLMAVQDIRVGGRQSNASYQYTLLSDDLAALREWEPKIRKKLATLPELADVNSDQQDNGAEMNLVYDRDTMARLGIDV 720
Cdd:PRK10503   655 DLYLQPTQDLTIDTQVSRTQYQFTLQATSLDALSTWVPKLMEKLQQLPQLSDVSSDWQDKGLVAYVNVDRDSASRLGISM 734
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  721 QAANSLLNNAFGQRQISTIYQPMNQYKVVMEVDPRYTQDISALEKMFVINNEGKAIPLSYFAKWQPANAPLSVNHQGLSA 800
Cdd:PRK10503   735 ADVDNALYNAFGQRLISTIYTQANQYRVVLEHNTENTPGLAALDTIRLTSSDGGVVPLSSIATIEQRFGPLSINHLDQFP 814
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  801 ASTISFNLPTGKSLSDASAAIDRAMTQLGVPSTVRGSFAGTAQVFQETMNSQVILIIAAIATVYIVLGILYESYVHPLTI 880
Cdd:PRK10503   815 STTISFNVPDGYSLGDAVQAIMDTEKTLNLPADITTQFQGSTLAFQSALGSTVWLIVAAVVAMYIVLGVLYESFIHPITI 894
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  881 LSTLPSAGVGALLALELFNAPFSLIALIGIMLLIGIVKKNAIMMVDFALEAQRHGNLTPQEAIFQACLLRFRPIMMTTLA 960
Cdd:PRK10503   895 LSTLPTAGVGALLALMIAGSELDVIAIIGIILLIGIVKKNAIMMIDFALAAEREQGMSPRDAIYQACLLRFRPILMTTLA 974
                          970       980       990      1000      1010      1020
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1425910443  961 ALFGALPLVLSGGDGSELRQPLGITIVGGLVMSQLLTLYTTPVVYLFFDRLRLRFSRKPKQTVTE 1025
Cdd:PRK10503   975 ALLGALPLMLSTGVGAELRRPLGICMVGGLIVSQVLTLFTTPVIYLLFDRLALYTKSRFPRHEEE 1039
2A0602 TIGR00915
The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Proteins ...
7-1025 1.05e-171

The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Proteins scoring above the trusted cutoff (1000) form a tight clade within the RND (Resistance-Nodulation-Cell Division) superfamily. Proteins scoring greater than the noise cutoff (100) appear to form a larger clade, cleanly separated from more distant homologs that include cadmium/zinc/cobalt resistance transporters. This family is one of several subfamilies within the scope of pfam00873. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Unknown substrate]


Pssm-ID: 273335 [Multi-domain]  Cd Length: 1044  Bit Score: 530.07  E-value: 1.05e-171
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443    7 FIYRPVATILLSVAITLCGILGFRMLPVAPLPQVDFPVIMVSASLPGASPETMASSVATPLERSLGRIAGVSEMTSSS-S 85
Cdd:TIGR00915    5 FIDRPIFAWVIAIIIMLAGTLSILSLPVSQYPSIAPPAITVSASYPGASAQTVQDTVTQVIEQNMNGIDGLRYMSSSSdS 84
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443   86 LGSTRIILQFDFDRDINGAARDVQAAINAAQSLLPSGMpSRPTYRKANPSDAPIMILTLTSD--TYSQGELYDFASTQLA 163
Cdd:TIGR00915   85 DGSMTITLTFEQGTDPDIAQVQVQNKLQLATPLLPQEV-QRQGVRVEKASSNFLMVIGLVSDdgSMTKEDLSDYAASNMV 163
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  164 PTISQIDGVADVDVGGSsLPAVRVGLNPQALFNQGVSLDDVRTAVSNANVRKPQG------ALEDGTHRWQIQTNDELKT 237
Cdd:TIGR00915  164 DPLSRLEGVGDVQLFGS-QYAMRIWLDPAKLNSYQLTPADVISAISAQNAQISAGqlgglpAVPGQQLNATIIAQTRLQT 242
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  238 AAEYQPLIIHYN-NGGAVRLGDVATVTDSVQDVRNAGMTNAKPAILLMIRKLPEANIIQTVDSIRAKLPELQETIPAAID 316
Cdd:TIGR00915  243 PEQFENILLKVNtDGSQVRLKDVARVELGGENYSISARFNGKPASGLAIKLATGANALDTAKAVKAELAVLEPFFPQGMK 322
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  317 LQIAQDRSPTIRASLEEVEQTLIISVALVILVVFLFLRSGRATIIPAVSVPVSLIGTFAAMYLCGFSLNNLSLMALTIAT 396
Cdd:TIGR00915  323 YVYPYDTTPFVEASIEEVVHTLIEAIVLVFLVMYLFLQNFRATLIPTIAVPVVLLGTFAVLAAFGFSINTLTMFAMVLAI 402
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  397 GFVVDDAIVVLENIARHL-EAGMKPLQAALQGTREVGFTVLSMSLSLVAVFLPLLLMGGLPGRLLREFAVTLSVAIGISL 475
Cdd:TIGR00915  403 GLLVDDAIVVVENVERVMaEEGLPPKEATRKSMGQIQGALVGIAMVLSAVFVPMAFFGGSTGAIYRQFSITIVSAMALSV 482
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  476 LVSLTLTPMMCGWMLKASKPREQKRLRG-----FGRMLVALQQGYGKSLKWVLNHTRLVGVVLLGTIALNIWLYISIPKT 550
Cdd:TIGR00915  483 LVALILTPALCATMLKPIEKGEHHEKKGgffgwFNRMFDSSTHGYENGVGKILRRRGRYLLVYVLLVGGMVFLFVRLPTS 562
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  551 FFPEQDTGVLMGGIQADQSISFQAMRGKLQDFMKIIRDDPA-----VDNVTGFT-GGSRVNSGMMFITLKPRDERS---E 621
Cdd:TIGR00915  563 FLPDEDQGVFMTIVQLPAGATAERTQAVLAQVTKYLLAKEKanvesVFTVNGFSfAGRGQNMGMAFIRLKDWEERTgkeN 642
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  622 TAQQIIDRLRVKLAKEPGANLFLMAVQDIRVGGRQSNASYQytlLSD----DLAALREWEPKIRKKLATLPELADVNSDQ 697
Cdd:TIGR00915  643 SVFAIAGRATGHFMQIKDAMVIAFVPPAILELGNATGFDFF---LQDraglGHEALLQARNQLLGLAAQNPALTRVRPNG 719
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  698 QDNGAEMNLVYDRDTMARLGIDVQAANSLLNNAFGQRQISTIYQPMNQYKVVMEVDPRYTQDISALEKMFVINNEGKAIP 777
Cdd:TIGR00915  720 LEDEPQLKIDIDREKAQALGVSIADINTTLSTAWGSSYVNDFIDRGRVKRVYVQAEEDARMSPEDINKWYVRNASGEMVP 799
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  778 LSYFA--KWQpANAPLSVNHQGLSAAStISFNLPTGKSLSDASAAIDRAMTQLgvPSTVrgSFAGTAQVFQETMN-SQVI 854
Cdd:TIGR00915  800 FSAFAtvRWE-YGSPQLERYNGLPSME-ILGSAAPGVSTGQAMAAMEAIAQKL--PPGF--GFSWTGMSYEERLSgSQAP 873
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  855 LIIA-AIATVYIVLGILYESYVHPLTILSTLPSAGVGALLALELFNAPFSLIALIGIMLLIGIVKKNAIMMVDFALEAQR 933
Cdd:TIGR00915  874 ALYAlSLLVVFLCLAALYESWSIPVSVMLVVPLGIIGALLATTLRGLSNDVYFQVGLLTTIGLSAKNAILIVEFAKELMA 953
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  934 HGNlTPQEAIFQACLLRFRPIMMTTLAALFGALPLVLSGGDGSELRQPLGITIVGGLVMSQLLTLYTTPVVYLFFDRLRL 1013
Cdd:TIGR00915  954 QGK-SIVEAALEAARLRLRPILMTSLAFILGVVPLAISTGAGSGSQHAIGTGVFGGMVTATVLAIFFVPLFYVVVRRLFK 1032
                         1050
                   ....*....|..
gi 1425910443 1014 RFSRKPKQTVTE 1025
Cdd:TIGR00915 1033 RKAHEKEMSVEH 1044
CusA COG3696
Cu/Ag efflux pump CusA [Inorganic ion transport and metabolism];
10-1014 3.58e-157

Cu/Ag efflux pump CusA [Inorganic ion transport and metabolism];


Pssm-ID: 442911 [Multi-domain]  Cd Length: 1031  Bit Score: 491.47  E-value: 3.58e-157
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443   10 RPVATILLSVAITLCGILGFRMLPVAPLP-----QVdfpVIMVSAslPGASPETMASSVATPLERSLGRIAGVSEMTSSS 84
Cdd:COG3696     12 NRLLVLLLTLLLAAAGIYSLRRLPIDAFPditnvQV---QVITEA--PGLSPEEVEQQVTYPIETALNGLPGVKEVRSIS 86
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443   85 SLGSTRIILQFDFDRDINGAARDVQAAINAAQSLLPSGmpsrptyrkANPSDAP-------IMILTLTSD--TYSQGELY 155
Cdd:COG3696     87 RFGLSVVTVIFEDGTDIYWARQLVLERLQQVREQLPAG---------VTPELGPistglgeIYQYTLESDpgKYSLMELR 157
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  156 DFASTQLAPTISQIDGVADVDVGGSSLPAVRVGLNPQALFNQGVSLDDVRTAVSNANVRKPQGALEDGTHRWQIQTNDEL 235
Cdd:COG3696    158 TLQDWVIRPQLRSVPGVAEVNSFGGFVKQYQVLVDPAKLRAYGLTLDDVIEALERNNANVGGGYIERGGQEYLVRGIGLI 237
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  236 KTAAEYQPLIIHYNNGGAVRLGDVATVTDSvQDVRN--AGMTNAKPAILLMIRKLPEANIIQTVDSIRAKLPELQETIPA 313
Cdd:COG3696    238 RSLEDIENIVVKTRNGTPVLLRDVAEVRIG-PAPRRgaATLNGEGEVVGGIVLMLKGENALEVIEAVKAKLAELKPSLPE 316
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  314 AIDLQIAQDRSPTIRASLEEVEQTLIISVALVILVVFLFLRSGRATIIPAVSVPVSLIGTFAAMYLCGFSLNNLSLMALT 393
Cdd:COG3696    317 GVKIVPFYDRSDLIDRAIHTVTKNLLEGALLVILVLFLFLGNLRAALIVALAIPLSLLFAFIVMRLFGISANLMSLGGLA 396
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  394 IATGFVVDDAIVVLENIARHLE------AGMKPLQAALQGTREVG----FTVLSMSLSLVAVFLplllmgglpgrllreF 463
Cdd:COG3696    397 IDFGIIVDGAVVMVENILRRLEenraagTPRERLEVVLEAAREVRrpifFATLIIILVFLPIFT---------------L 461
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  464 -----------AVTLSVAIGISLLVSLTLTPMMCGWMLKASKPREQKRLrgfgrmLVALQQGYGKSLKWVLNHTRLVGVV 532
Cdd:COG3696    462 egvegklfrpmALTVIFALLGALLLSLTLVPVLASLLLRGKVPEKENPL------VRWLKRLYRPLLRWALRHPKLVLAV 535
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  533 LLGTIALNIWLYISIPKTFFPEQDTGVLMGGIQADQSISFQAMRGKLQDFMKIIRDDPAVDNVTGFTGgsR--------- 603
Cdd:COG3696    536 ALVLLVLALALFPRLGSEFLPELDEGDLLVMATLPPGISLEESVELGQQVERILKSFPEVESVVSRTG--Raedatdpmg 613
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  604 VNSGMMFITLKPRDE--RSETAQQIIDRLRVKLAKEPGANL-FLMAVQDiRV-----GGRQSNAsyqYTLLSDDLAALRE 675
Cdd:COG3696    614 VNMSETFVILKPRSEwrSGRTKEELIAEMREALEQIPGVNFnFSQPIQM-RVdellsGVRADVA---VKIFGDDLDVLRR 689
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  676 WEPKIRKKLATLPELADVNSDQQDNGAEMNLVYDRDTMARLGIDVQAANSLLNNAFGQRQISTIYQPMNQYKVVMEVDPR 755
Cdd:COG3696    690 LAEQIEAVLKTVPGAADVQVERVTGLPQLDIRIDRDAAARYGLNVADVQDVVETAIGGKAVGQVYEGERRFDIVVRLPEE 769
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  756 YTQDISALEKMFVINNEGKAIPLSYFAKWQPANAPLSVNHQGLSAASTISFNLpTGKSLS----DASAAIDRamtQLGVP 831
Cdd:COG3696    770 LRDDPEAIRNLPIPTPSGAQVPLSQVADIEVVEGPNQISRENGRRRIVVQANV-RGRDLGsfvaEAQAKVAE---QVKLP 845
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  832 STVRGSFAGTAQVFQETMNSQVILIIAAIATVYIVLGILYESYVHPLTILSTLPSAGVGALLALELFNAPFSLIALIGIM 911
Cdd:COG3696    846 PGYYIEWGGQFENLQRATARLAIVVPLALLLIFLLLYLAFGSVRDALLILLNVPFALIGGVLALWLRGMPLSVSAGVGFI 925
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  912 LLIGIVKKNAIMMVDFALEAQRHGnLTPQEAIFQACLLRFRPIMMTTLAALFGALPLVLSGGDGSELRQPLGITIVGGLV 991
Cdd:COG3696    926 ALFGVAVLNGVVLVSYINQLRAEG-LDLREAIIEGALERLRPVLMTALVAALGLLPMALSTGPGSEVQRPLATVVIGGLI 1004
                         1050      1060
                   ....*....|....*....|...
gi 1425910443  992 MSQLLTLYTTPVVYLFFDRLRLR 1014
Cdd:COG3696   1005 TSTLLTLLVLPALYLLFGRRRLR 1027
PRK09579 PRK09579
multidrug efflux RND transporter permease subunit;
1-1005 2.17e-140

multidrug efflux RND transporter permease subunit;


Pssm-ID: 169983 [Multi-domain]  Cd Length: 1017  Bit Score: 446.97  E-value: 2.17e-140
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443    1 MKFFALFIYRPVATILLSVAITLCGILGFRMLPVAPLPQVDFPVIMVSASLPGASPETMASSVATPLERSLGRIAGVSEM 80
Cdd:PRK09579     1 MAFTDPFIRRPVLASVVSLLIVLLGFQAWSKLQIRQYPQMENALITVTTAYPGANAETIQGYITQPLQQSLASAEGIDYM 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443   81 TSSSSLGSTRIILQFDFDRDINGAARDVQAAINAAQSLLPSGMPSrPTYRKANPSDAPIMILTLTSDTYSQGELYDFAST 160
Cdd:PRK09579    81 TSVSRQNFSIISIYARIGADSDRLFTELLAKANEVKNQLPQDAED-PVLSKEAADASALMYISFYSEEMSNPQITDYLSR 159
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  161 QLAPTISQIDGVADVDVGGSSLPAVRVGLNPQALFNQGVSLDDVRTAVSNANVRKPQGALEDGTHRWQIQTNDELKTAAE 240
Cdd:PRK09579   160 VIQPKLATLPGMAEAEILGNQVFAMRLWLDPVKLAGFGLSAGDVTQAVRRYNFLSAAGEVKGEYVVTSINASTELKSAEA 239
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  241 YQPLIIHYNNGGAVRLGDVATVTDSVQDVRNAGMTNAKPAILLMIRKLPEANIIQTVDSIRAKLPELQETIPAAIDLQIA 320
Cdd:PRK09579   240 FAAIPVKTSGDSRVLLGDVARVEMGAENYDSISSFDGIPSVYIGIKATPSANPLDVIKEVRAIMPELESQLPPNLKVSIA 319
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  321 QDRSPTIRASLEEVEQTLIISVALVILVVFLFLRSGRATIIPAVSVPVSLIGTFAAMYLCGFSLNNLSLMALTIATGFVV 400
Cdd:PRK09579   320 YDATLFIQASIDEVVKTLGEAVLIVIVVVFLFLGALRSVLIPVVTIPLSMIGVLFFMQMMGYSINLLTLLAMVLAIGLVV 399
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  401 DDAIVVLENIARHLEAGMKPLQAALQGTREVGFTVLSMSLSLVAVFLPLLLMGGLPGRLLREFAVTLSVAIGISLLVSLT 480
Cdd:PRK09579   400 DDAIVVVENIHRHIEEGKSPFDAALEGAREIAMPVVSMTITLAAVYAPIGFLTGLTGALFKEFALTLAGAVIISGIVALT 479
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  481 LTPMMCGWMLkaskpREQKRLRGFG----RMLVALQQGYGKSLKWVLNHTRLVGVVLLGTIALNIWLYISIPKTFFPEQD 556
Cdd:PRK09579   480 LSPMMCALLL-----RHEENPSGLAhrldRLFERLKQRYQRALHGTLNTRPVVLVFAVIVLALIPVLLKFTQSELAPEED 554
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  557 TGVLMGGIQADQSISFQAMRGKLQDFMKIIRDDPAVDNVTGFTGGSRVNSGMMFITLKPRDERSETAQQIIDRLRVKLAK 636
Cdd:PRK09579   555 QGIIFMMSSSPQPANLDYLNAYTDEFTPIFKSFPEYYSSFQINGFNGVQSGIGGFLLKPWNERERTQMELLPLVQAKLEE 634
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  637 EPGANLFLMAVQDIRVGGRqsNASYQYTL-LSDDLAALREWEPKIRKKLATLPELADVNSDQQDNGAEMNLVYDRDTMAR 715
Cdd:PRK09579   635 IPGLQIFGFNLPSLPGTGE--GLPFQFVInTANDYESLLQVAQRVKQRAQESGKFAFLDIDLAFDKPEVVVDIDRAKAAQ 712
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  716 LGIDVQAANSLLNNAFGQRQISTIYQPMNQYKVVMEVDPRYTQDISALEKMFVINNEGKAIPLSYFAKWQPANAPLSVNH 795
Cdd:PRK09579   713 MGVSMQDLGGTLATLLGEGEINRFTIDGRSYKVIAQVERPYRDNPGWLNNYYVKNEQGQLLPLSTLITLSDRARPRQLNQ 792
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  796 -QGLSAAstisfnLPTGKSLSDASAAID--RAMTQLGVPSTVRGSFAGTAQVFQETMNSQVILIIAAIATVYIVLGILYE 872
Cdd:PRK09579   793 fQQLNSA------IISGFPIVSMGEAIEtvQQIAREEAPEGFAFDYAGASRQYVQEGSALWVTFGLALAIIFLVLAAQFE 866
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  873 SYVHPLTILSTLPSAGVGALLALELFNAPFSLIALIGIMLLIGIVKKNAIMMVDFALEAQRHGNLTPQEAIFQACLLRFR 952
Cdd:PRK09579   867 SFRDPLVILVTVPLSICGALIPLFLGVSSMNIYTQVGLVTLIGLISKHGILIVEFANQLRHEQGLSRREAIEEAAAIRLR 946
                          970       980       990      1000      1010
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1425910443  953 PIMMTTLAALFGALPLVLSGGDGSELRQPLGITIVGGLVMSQLLTLYTTPVVY 1005
Cdd:PRK09579   947 PVLMTTAAMVFGMVPLILATGAGAVSRFDIGLVIATGMSIGTLFTLFVLPCIY 999
PRK09577 PRK09577
multidrug efflux RND transporter permease subunit;
7-1019 1.19e-131

multidrug efflux RND transporter permease subunit;


Pssm-ID: 169981 [Multi-domain]  Cd Length: 1032  Bit Score: 424.26  E-value: 1.19e-131
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443    7 FIYRPVATILLSVAITLCGILGFRMLPVAPLPQVDFPVIMVSASLPGASPETMASSVATPLERSLGRIAGVSEMTSSSSL 86
Cdd:PRK09577     5 FIDRPVFAWVISLFIMLGGIFAIRALPVAQYPDIAPPVVSIYATYPGASAQVVEESVTALIEREMNGAPGLLYTSATSSA 84
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443   87 GSTRIILQFDFDRDINGAARDVQAAINAAQSLLPSGMpSRPTYRKANPSDAPIMILTLTSDT--YSQGELYDFASTQLAP 164
Cdd:PRK09577    85 GQASLSLTFKQGVNADLAAVEVQNRLKTVEARLPEPV-RRDGIQVEKAADNIQLIVSLTSDDgrLTGVELGEYASANVLQ 163
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  165 TISQIDGVADVDVGGSSLpAVRVGLNPQALFNQGVSLDDVRTAVSNANVRKPQGAL------EDGTHRWQIQTNDELKTA 238
Cdd:PRK09577   164 ALRRVEGVGKVQFWGAEY-AMRIWPDPVKLAALGLTASDIASAVRAHNARVTIGDIgrsavpDSAPIAATVFADAPLKTP 242
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  239 AEYQPLIIHYN-NGGAVRLGDVATVTDSVQDVRNAGMTNAKPAILLMIRKLPEANIIQTVDSIRAKLPELQETIPAAIDL 317
Cdd:PRK09577   243 EDFGAIALRARaDGSALYLRDVARIEFGGNDYNYPSYVNGKTATGMGIKLAPGSNAVATEKRVRATMDELSRYFPPGVKY 322
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  318 QIAQDRSPTIRASLEEVEQTLIISVALVILVVFLFLRSGRATIIPAVSVPVSLIGTFAAMYLCGFSLNNLSLMALTIATG 397
Cdd:PRK09577   323 QIPYETSSFVRVSMNKVVTTLIEAGVLVFLVMFLFMQNFRATLIPTLVVPVALLGTFGVMLAAGFSINVLTMFGMVLAIG 402
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  398 FVVDDAIVVLENIARHL-EAGMKPLQAALQGTREVGFTVLSMSLSLVAVFLPLLLMGGLPGRLLREFAVTLSVAIGISLL 476
Cdd:PRK09577   403 ILVDDAIVVVENVERLMvEEGLSPYDATVKAMKQISGAIVGITVVLTSVFVPMAFFGGAVGNIYRQFALSLAVSIGFSAF 482
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  477 VSLTLTPMMCGWMLK-ASKPREQKR--LRGFGRMLVALQQGY--------GKSLKWVLNHTRLVGVVLLgtialniwLYI 545
Cdd:PRK09577   483 LALSLTPALCATLLKpVDGDHHEKRgfFGWFNRFVARSTQRYatrvgailKRPLRWLVVYGALTAAAAL--------LFT 554
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  546 SIPKTFFPEQDTGVLMGGIQADQSISFQAMRGKLQDFMKIIRDDPAVDNVTGFTG----GSRVNSGMMFITLKPRDERSE 621
Cdd:PRK09577   555 RLPTAFLPDEDQGNFMVMVIRPQGTPLAETMQSVREVESYLRRHEPVAYTFALGGfnlyGEGPNGGMIFVTLKDWKERKA 634
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  622 TAQQ---IIDRLRVKLAKEPGANLFLMAVQ-----------DIRVGGRqSNASYQytllsdDLAALREwepKIRKKLATL 687
Cdd:PRK09577   635 ARDHvqaIVARINERFAGTPNTTVFAMNSPalpdlgstsgfDFRLQDR-GGLGYA------AFVAARE---QLLAEGAKD 704
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  688 PELADVNSDQQDNGAEMNLVYDRDTMARLGIDVQAANSLLNNAFGQRQISTIYQPMNQYKVVMEVDPRYTQDISALEKMF 767
Cdd:PRK09577   705 PALTDLMFAGTQDAPQLKLDIDRAKASALGVSMDEINTTLAVMFGSDYIGDFMHGSQVRRVIVQADGRHRLDPDDVKKLR 784
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  768 VINNEGKAIPLSYFAKWQPANAPLSVNHQGLSAASTISFNLPTGKSLSDASAAIDRAMTQLgvPSTVrgSFAGTAQVFQE 847
Cdd:PRK09577   785 VRNAQGEMVPLAAFATLHWTLGPPQLTRYNGYPSFTINGSAAPGHSSGEAMAAIERIAATL--PAGI--GYAWSGQSFEE 860
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  848 TMN-SQVILIIA-AIATVYIVLGILYESYVHPLTILSTLPSAGVGALLALELFNAPFSLIALIGIMLLIGIVKKNAIMMV 925
Cdd:PRK09577   861 RLSgAQAPMLFAlSVLVVFLALAALYESWSIPFAVMLVVPLGVIGAVLGVTLRGMPNDIYFKVGLIATIGLSAKNAILIV 940
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  926 DFA--LEAQRHGNLtpqEAIFQACLLRFRPIMMTTLAALFGALPLVLSGGDGSELRQPLGITIVGGLVMSQLLTLYTTPV 1003
Cdd:PRK09577   941 EVAkdLVAQRMSLA---DAALEAARLRLRPIVMTSLAFGVGVLPLAFASGAASGAQIAIGTGVLGGVITATVLAVFLVPL 1017
                         1050
                   ....*....|....*.
gi 1425910443 1004 VYLFFDRLrLRFSRKP 1019
Cdd:PRK09577  1018 FFVVVGRL-FDVGPRR 1032
PRK10555 PRK10555
multidrug efflux RND transporter permease AcrD;
7-1020 3.19e-125

multidrug efflux RND transporter permease AcrD;


Pssm-ID: 182544 [Multi-domain]  Cd Length: 1037  Bit Score: 407.29  E-value: 3.19e-125
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443    7 FIYRPVATILLSVAITLCGILGFRMLPVAPLPQVDFPVIMVSASLPGASPETMASSVATPLERSLGRIAGVSEMTS-SSS 85
Cdd:PRK10555     5 FIDRPIFAWVLAILLCLTGTLAIFSLPVEQYPDLAPPNVRITANYPGASAQTLENTVTQVIEQNMTGLDNLMYMSSqSSG 84
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443   86 LGSTRIILQFDFDRDINGAARDVQAAINAAQSLLPSGMPSRP-TYRKANPSDAPIMILTLTSDTYSQGELYDFASTQLAP 164
Cdd:PRK10555    85 TGQASVTLSFKAGTDPDEAVQQVQNQLQSAMRKLPQAVQNQGvTVRKTGDTNILTIAFVSTDGSMDKQDIADYVASNIQD 164
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  165 TISQIDGVADVDVGGSSLpAVRVGLNPQALFNQGVSLDDVRTAVSNANVRKPQGAL------EDGTHRWQIQTNDELKTA 238
Cdd:PRK10555   165 PLSRVNGVGDIDAYGSQY-SMRIWLDPAKLNSFQMTTKDVTDAIESQNAQIAVGQLggtpsvDKQALNATINAQSLLQTP 243
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  239 AEYQPLIIHYN-NGGAVRLGDVATVTDSVQDVRNAGMTNAKPAILLMIRKLPEANIIQTVDSIRAKLPELQETIPAAIDL 317
Cdd:PRK10555   244 EQFRDITLRVNqDGSEVTLGDVATVELGAEKYDYLSRFNGKPASGLGVKLASGANEMATAKLVLNRLDELAQYFPHGLEY 323
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  318 QIAQDRSPTIRASLEEVEQTLIISVALVILVVFLFLRSGRATIIPAVSVPVSLIGTFAAMYLCGFSLNNLSLMALTIATG 397
Cdd:PRK10555   324 KVAYETTSFVKASIEDVVKTLLEAIALVFLVMYLFLQNFRATLIPTIAVPVVLMGTFSVLYAFGYSINTLTMFAMVLAIG 403
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  398 FVVDDAIVVLENIARHL-EAGMKPLQAALQGTREVGFTVLSMSLSLVAVFLPLLLMGGLPGRLLREFAVTLSVAIGISLL 476
Cdd:PRK10555   404 LLVDDAIVVVENVERIMsEEGLTPREATRKSMGQIQGALVGIAMVLSAVFVPMAFFGGTTGAIYRQFSITIVSAMVLSVL 483
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  477 VSLTLTPMMCGWMLKASKPREQKRLRG--------FGRMLVALQQGYGK----SLKWVlnhtrLVGVVLLGTIAlniWLY 544
Cdd:PRK10555   484 VAMILTPALCATLLKPLKKGEHHGQKGffgwfnrmFNRNAERYEKGVAKilhrSLRWI-----LIYVLLLGGMV---FLF 555
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  545 ISIPKTFFPEQDTGVLMGGIQADQSISFQAMRGKLQDFMKIIRDDPAVDNVTGFT------GGSRVNSGMMFITLKPRDE 618
Cdd:PRK10555   556 LRLPTSFLPLEDRGMFTTSVQLPSGSTQQQTLKVVEKVEKYYFTHEKDNVMSVFAtvgsgpGGNGQNVARMFIRLKDWDE 635
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  619 R---SETAQQIIDRLRVKLAKEPGANLFlmAVQDIRVGGRQSNASYQYTLLS------DDLAALREwepKIRKKLATLPE 689
Cdd:PRK10555   636 RdskTGTSFAIIERATKAFNKIKEARVI--ASSPPAISGLGSSAGFDMELQDhagaghDALMAARN---QLLALAAKNPE 710
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  690 LADVNSDQQDNGAEMNLVYDRDTMARLGIDVQAANSLLNNAFGQRQISTIYQPMNQYKVVMEVDPRYTQDISALEKMFVI 769
Cdd:PRK10555   711 LTRVRHNGLDDSPQLQIDIDQRKAQALGVSIDDINDTLQTAWGSSYVNDFMDRGRVKKVYVQAAAPYRMLPDDINLWYVR 790
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  770 NNEGKAIPLSYFA--KWQpANAPLSVNHQGLSAASTISFNLPtGKSLSDASAAIDRAMTQLgvPSTVrgSFAGTAQVFQE 847
Cdd:PRK10555   791 NKDGGMVPFSAFAtsRWE-TGSPRLERYNGYSAVEIVGEAAP-GVSTGTAMDIMESLVKQL--PNGF--GLEWTAMSYQE 864
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  848 TMN-SQVILIIA-AIATVYIVLGILYESYVHPLTILSTLPSAGVGALLALELFNAPFSLIALIGIMLLIGIVKKNAIMMV 925
Cdd:PRK10555   865 RLSgAQAPALYAiSLLVVFLCLAALYESWSVPFSVMLVVPLGVIGALLATWMRGLENDVYFQVGLLTVIGLSAKNAILIV 944
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  926 DFALEAQRHGNlTPQEAIFQACLLRFRPIMMTTLAALFGALPLVLSGGDGSELRQPLGITIVGGLVMSQLLTLYTTPvvy 1005
Cdd:PRK10555   945 EFANEMNQKGH-DLFEATLHASRQRLRPILMTSLAFIFGVLPMATSTGAGSGSQHAVGTGVMGGMISATILAIFFVP--- 1020
                         1050
                   ....*....|....*
gi 1425910443 1006 LFFDRLRLRFSRKPK 1020
Cdd:PRK10555  1021 LFFVLVRRRFPLKPR 1035
PRK15127 PRK15127
multidrug efflux RND transporter permease subunit AcrB;
6-1018 8.54e-119

multidrug efflux RND transporter permease subunit AcrB;


Pssm-ID: 185081 [Multi-domain]  Cd Length: 1049  Bit Score: 390.03  E-value: 8.54e-119
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443    6 LFIYRPVATILLSVAITLCGILGFRMLPVAPLPQVDFPVIMVSASLPGASPETMASSVATPLERSLGRIAGVSEMTSSS- 84
Cdd:PRK15127     4 FFIDRPIFAWVIAIIIMLAGGLAILKLPVAQYPTIAPPAVTISASYPGADAKTVQDTVTQVIEQNMNGIDNLMYMSSNSd 83
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443   85 SLGSTRIILQFDFDRDINGAARDVQAAINAAQSLLPSGMPSRP-TYRKANPSDAPIMILTLTSDTYSQGELYDFASTQLA 163
Cdd:PRK15127    84 STGTVQITLTFESGTDADIAQVQVQNKLQLAMPLLPQEVQQQGvSVEKSSSSFLMVVGVINTDGTMTQEDISDYVAANMK 163
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  164 PTISQIDGVADVDVGGSSLpAVRVGLNPQALFNQGVSLDDVRTAVSNANVRKPQGALeDGTH-------RWQIQTNDELK 236
Cdd:PRK15127   164 DPISRTSGVGDVQLFGSQY-AMRIWMNPNELNKFQLTPVDVINAIKAQNAQVAAGQL-GGTPpvkgqqlNASIIAQTRLT 241
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  237 TAAEYQPLIIHYN-NGGAVRLGDVATVTDSVQDVRNAGMTNAKPAILLMIRKLPEANIIQTVDSIRAKLPELQETIPAAI 315
Cdd:PRK15127   242 STEEFGKILLKVNqDGSRVRLRDVAKIELGGENYDIIAEFNGQPASGLGIKLATGANALDTAAAIRAELAKMEPFFPSGL 321
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  316 DLQIAQDRSPTIRASLEEVEQTLIISVALVILVVFLFLRSGRATIIPAVSVPVSLIGTFAAMYLCGFSLNNLSLMALTIA 395
Cdd:PRK15127   322 KIVYPYDTTPFVKISIHEVVKTLVEAIILVFLVMYLFLQNFRATLIPTIAVPVVLLGTFAVLAAFGFSINTLTMFGMVLA 401
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  396 TGFVVDDAIVVLENIARHL-EAGMKPLQAALQGTREVGFTVLSMSLSLVAVFLPLLLMGGLPGRLLREFAVTLSVAIGIS 474
Cdd:PRK15127   402 IGLLVDDAIVVVENVERVMaEEGLPPKEATRKSMGQIQGALVGIAMVLSAVFVPMAFFGGSTGAIYRQFSITIVSAMALS 481
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  475 LLVSLTLTPMMCGWMLKASKPREQKRLRG-----FGRMLVALQQGYGKSLKWVLNHTRLVGVVLLGTIALNIWLYISIPK 549
Cdd:PRK15127   482 VLVALILTPALCATMLKPIAKGDHGEGKKgffgwFNRMFEKSTHHYTDSVGNILRSTGRYLVLYLIIVVGMAYLFVRLPS 561
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  550 TFFPEQDTGVLMGGIQ----ADQSISFQAMRGKLQDFMKIIRDD-PAVDNVTGFT-GGSRVNSGMMFITLKPRDERSETA 623
Cdd:PRK15127   562 SFLPDEDQGVFLTMVQlpagATQERTQKVLNEVTDYYLTKEKNNvESVFAVNGFGfAGRGQNTGIAFVSLKDWADRPGEE 641
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  624 QQ---IIDRLRVKLAKEPGANLFLMAVQDIRVGGRQSNASYQYT----LLSDDLAALREwepKIRKKLATLPE-LADVNS 695
Cdd:PRK15127   642 NKveaITMRATRAFSQIKDAMVFAFNLPAIVELGTATGFDFELIdqagLGHEKLTQARN---QLLGEAAKHPDmLVGVRP 718
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  696 DQQDNGAEMNLVYDRDTMARLGIDVQAANSLLNNAFGQRQISTIYQPMNQYKVVMEVDPRYTQDISALEKMFVINNEGKA 775
Cdd:PRK15127   719 NGLEDTPQFKIDIDQEKAQALGVSISDINTTLGAAWGGSYVNDFIDRGRVKKVYVMSEAKYRMLPDDIGDWYVRAADGQM 798
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  776 IPLSYF--AKWQpANAPLSVNHQGLSAASTISFNLPtGKSLSDASAAIDRAMTQLgvPSTVrgSFAGTAQVFQETM--NS 851
Cdd:PRK15127   799 VPFSAFssSRWE-YGSPRLERYNGLPSMEILGQAAP-GKSTGEAMELMEELASKL--PTGV--GYDWTGMSYQERLsgNQ 872
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  852 QVILIIAAIATVYIVLGILYESYVHPLTILSTLPSAGVGALLALELFNAPFSLIALIGIMLLIGIVKKNAIMMVDFALEA 931
Cdd:PRK15127   873 APALYAISLIVVFLCLAALYESWSIPFSVMLVVPLGVIGALLAATFRGLTNDVYFQVGLLTTIGLSAKNAILIVEFAKDL 952
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  932 QRHGNLTPQEAIFQACLLRFRPIMMTTLAALFGALPLVLSGGDGSELRQPLGITIVGGLVMSQLLTLYTTPVvylFFDRL 1011
Cdd:PRK15127   953 MDKEGKGLIEATLEAVRMRLRPILMTSLAFILGVMPLVISSGAGSGAQNAVGTGVMGGMVTATVLAIFFVPV---FFVVV 1029

                   ....*..
gi 1425910443 1012 RLRFSRK 1018
Cdd:PRK15127  1030 RRRFSRK 1036
2A0601 TIGR00914
heavy metal efflux pump, CzcA family; This model represents a family of H+/heavy metal cation ...
15-1012 2.67e-86

heavy metal efflux pump, CzcA family; This model represents a family of H+/heavy metal cation antiporters. This family is one of several subfamilies within the scope of pfam00873. [Cellular processes, Detoxification, Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 129992 [Multi-domain]  Cd Length: 1051  Bit Score: 300.52  E-value: 2.67e-86
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443   15 ILLSVAITLCGILGFRMLPVAPLPQVDFPVIMVSASLPGASPETMASSVATPLERSLGRIAGVSEMTSSSSLGSTRIILQ 94
Cdd:TIGR00914   17 LLATLVMAILGIWSYNRLPIDAVPDITNVQVQINTSAPGYSPLEVEQRVTYPIETAMAGLPGLETTRSLSRYGLSQVTVI 96
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443   95 FDFDRDINGAARDVQAAINAAQSLLPSGMpsRPTYRKANPSDAPIMILTLTSD---TYSQGELYDFA---STQ---LAPT 165
Cdd:TIGR00914   97 FKDGTDLYFARQLVNERLQQARDNLPEGV--SPEMGPISTGLGEIFLYTVEAEegaRKKDGGAYTLTdlrTIQdwiIRPQ 174
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  166 ISQIDGVADVDVGGSSLPAVRVGLNPQALFNQGVSLDDVRTAVSNANVRKPQGALEDGTHRWQIQTNDELKTAAEYQPLI 245
Cdd:TIGR00914  175 LRTVPGVAEVNSIGGYVKQFLVAPDPEKLAAYGLSLADVVNALERNNQNVGAGYIERRGEQYLVRAPGQVQSMDDIRNIV 254
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  246 IHYNNGGAVRLGDVATVTDSVQDVRNAGMTNAKPAILLMIRKLPEANIIQTVDSIRAKLPELQETIPAAIDLQIAQDRSP 325
Cdd:TIGR00914  255 IATGEGVPIRIRDVARVQIGKELRTGAATENGKEVVLGTVFMLIGENSRTVAQAVGDKLETINKTLPEGVEIVTTYDRSQ 334
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  326 TIRASLEEVEQTLIISVALVILVVFLFLRSGRATIIPAVSVPVSLIGTFAAMYLCGFSLNNLSLMALtiATGFVVDDAIV 405
Cdd:TIGR00914  335 LVDAAIATVKKNLLEGALLVIVILFLFLGNIRAALIAATVIPLSLLITFIGMVFQGISANLMSLGAL--DFGLIVDGAVV 412
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  406 VLENIARHLEAGM----------KPLQAALQGTREVGFTVLSMSLSLVAVFLPLLLMGGLPGRLLREFAVTLSVAIGISL 475
Cdd:TIGR00914  413 IVENAHRRLAEAQhhhgrqltlkERLHEVFAASREVRRPLIFGQLIITLVFLPIFTLTGVEGKMFHPMAFTVVLALAGAM 492
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  476 LVSLTLTPMMCGWMLKASKPREQKRLrgfgrmLVALQQGYGKSLKWVLNHTRLVGVVLLGTIALNIWLYISIPKTFFPEQ 555
Cdd:TIGR00914  493 ILSLTFVPAAVALFIRGKVAEKENRL------MRVLKRRYEPLLERVLAWPAVVLGAAAVSIVLVVWIASRVGGEFIPSL 566
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  556 DTGVL------MGGIQADQSISFQamrgklQDFMKIIRDDPAVDNVTGFTGGSRVNSGMM-------FITLKPRDERSE- 621
Cdd:TIGR00914  567 NEGDLayqalrIPGTSLAQSVAMQ------QTLEKLIKSFPEVARVFAKTGTAEIATDPMppnasdtYIILKPESQWPEg 640
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  622 --TAQQIIDRLRVKLAKEPG-ANLFLMAVQ---DIRVGGRQSNASYQytLLSDDLAALREWEPKIRKKLATLPELADVNS 695
Cdd:TIGR00914  641 kkTKEDLIEEIQEATVRIPGnNYEFTQPIQmrfNELISGVRSDVAVK--VFGDDLDDLDATAEKISAVLKGVPGAADVKV 718
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  696 DQQDNGAEMNLVYDRDTMARLGIDVQAANSLLNNAFGQRQISTIYQPMNQYKVVMEVDPRYTQDISALEKMFVINNEGKA 775
Cdd:TIGR00914  719 EQTTGLPYLTVEIDREKAARYGLTVGDVQDTVATAVGGRMSGETFEGDRRFDIVIRLPESLRESPQALRQLPIPLPLSED 798
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  776 -----IPLSYFAKWQPANAPLSVNHQGLSAASTISFNL---PTGKSLSDASAAIDRamtQLGVPSTVRGSFAGTAQVFQE 847
Cdd:TIGR00914  799 arkqfIPLSDVADLRVSPGPNQISRENGKRRVVVSANVrgrDLGSFVDDAKKAIAE---QVKLPPGYWITWGGQFEQLQS 875
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  848 TMNSQVILIIAAIATVYIVLGILYESYVHPLTILSTLPSAGVGALLALELFNAPFSLIALIGIMLLIGIVKKNAIMMVDF 927
Cdd:TIGR00914  876 ATKRLQIVVPVTLLLIFVLLYAAFGNVKDALLVFTGIPFALTGGVFALWLRGIPLSISAAVGFIALSGVAVLNGLVMISF 955
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  928 ---ALEAQRhgnlTPQEAIFQACLLRFRPIMMTTLAALFGALPLVLSGGDGSELRQPLGITIVGGLVMSQLLTLYTTPVV 1004
Cdd:TIGR00914  956 irkLLEEGP----SLDEAVYEGALTRVRPVLMTALVASLGFVPMAIATGTGAEVQRPLATVVIGGIITATLLTLFVLPAL 1031

                   ....*...
gi 1425910443 1005 YLFFDRLR 1012
Cdd:TIGR00914 1032 YRLVHRRR 1039
MMPL COG1033
Predicted exporter protein, RND superfamily [General function prediction only];
327-1014 1.29e-23

Predicted exporter protein, RND superfamily [General function prediction only];


Pssm-ID: 440656 [Multi-domain]  Cd Length: 767  Bit Score: 107.64  E-value: 1.29e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  327 IRASLEEVEQTLIISVALVILVVFLFLRSGRATIIPAVSVPVSLIGTFAAMYLCGFSLNNLSLMALTIATGFVVDDAIVV 406
Cdd:COG1033    213 AEAIQSDLAIFFPLALLLILLLLFLFFRSLRGVLLPLLVVLLAVIWTLGLMGLLGIPLSPLTILVPPLLLAIGIDYGIHL 292
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  407 LENIARHLEAGMKPLQAALQGTREVGFTVLSMSLSLVAVFlplLLMGGLPGRLLREFAVTLSVAIGISLLVSLTLTPMMC 486
Cdd:COG1033    293 LNRYREERRKGLDKREALREALRKLGPPVLLTSLTTAIGF---LSLLFSDIPPIRDFGIVAAIGVLLAFLTSLTLLPALL 369
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  487 GWM-LKASKPREQKRLRGFGRMLVALqqgygksLKWVLNHTRLVGVVLLGTIALNIWLYISIPKTFFPEQDtgvlmggiq 565
Cdd:COG1033    370 SLLpRPKPKTRRLKKPPELGRLLAKL-------ARFVLRRPKVILVVALVLAVVSLYGISRLKVEYDFEDY--------- 433
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  566 adqsisfqamrgkLQDFMKIIRDDPAVDNVTGftggsrvnsGMMFITLkprdersetaqqIIDrlrvklAKEPGANLflm 645
Cdd:COG1033    434 -------------LPEDSPIRQDLDFIEENFG---------GSDPLEV------------VVD------TGEPDGLK--- 470
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  646 avqdirvggrqsnasyqytllsdDLAALREWEpKIRKKLATLPELADVNSdqqdngaemnLVydrDTMARLgidvqaaNS 725
Cdd:COG1033    471 -----------------------DPEVLKEID-RLQDYLESLPEVGKVLS----------LA---DLVKEL-------NQ 506
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  726 LLNNafGQRQISTIyqPMNQYKVVMEVDPRYTQDISALEKMfvINNEGKAIPLSYFAKWQPANAplsvnhqglsaastis 805
Cdd:COG1033    507 ALNE--GDPKYYAL--PESRELLAQLLLLLSSPPGDDLSRF--VDEDYSAARVTVRLKDLDSEE---------------- 564
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  806 fnlptgksLSDASAAIDRAMTQLGVPSTVRGSFAGTAQVFQETMN----SQVILIIAAIATVYIVLGILYESYVHPLTIL 881
Cdd:COG1033    565 --------IKALVEEVRAFLAENFPPDGVEVTLTGSAVLFAAINEsvieSQIRSLLLALLLIFLLLLLAFRSLRLGLISL 636
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  882 --STLPSAGVGALLAleLFNAPFSLIALIGIMLLIGIVKKNAIMMVDFALEAQRHGnLTPQEAIFQACLLRFRPIMMTTL 959
Cdd:COG1033    637 ipNLLPILLTFGLMG--LLGIPLNIATAVVASIALGIGVDYTIHFLSRYREERRKG-GDLEEAIRRALRTTGKAILFTSL 713
                          650       660       670       680       690
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1425910443  960 AALFGALPLVLSGGDGseLRQpLGITIVGGLVMSQLLTLYTTPVVYLFFDRLRLR 1014
Cdd:COG1033    714 TLAAGFGVLLFSSFPP--LAD-FGLLLALGLLVALLAALLLLPALLLLLDPRIAK 765
MMPL COG1033
Predicted exporter protein, RND superfamily [General function prediction only];
281-500 9.01e-16

Predicted exporter protein, RND superfamily [General function prediction only];


Pssm-ID: 440656 [Multi-domain]  Cd Length: 767  Bit Score: 82.22  E-value: 9.01e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  281 ILLMIRKLPEANIIQTVDSIRAKLPELQEtiPAAIDLQIAqDRSPTIRASLEEVEQTLIISVALVILVVFLFL----RSG 356
Cdd:COG1033    553 VTVRLKDLDSEEIKALVEEVRAFLAENFP--PDGVEVTLT-GSAVLFAAINESVIESQIRSLLLALLLIFLLLllafRSL 629
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  357 RATIIPAVSVPVSLIGTFAAMYLCGFSLNNLSLMALTIATGFVVDDAIVVLENIARHLEAGMKPLQAALQGTREVGFTVL 436
Cdd:COG1033    630 RLGLISLIPNLLPILLTFGLMGLLGIPLNIATAVVASIALGIGVDYTIHFLSRYREERRKGGDLEEAIRRALRTTGKAIL 709
                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1425910443  437 SMSLSLVAVFlplLLMGGLPGRLLREFAVTLSVAIGISLLVSLTLTPMMCGWMlkasKPREQKR 500
Cdd:COG1033    710 FTSLTLAAGF---GVLLFSSFPPLADFGLLLALGLLVALLAALLLLPALLLLL----DPRIAKK 766
MMPL COG1033
Predicted exporter protein, RND superfamily [General function prediction only];
793-1020 4.12e-09

Predicted exporter protein, RND superfamily [General function prediction only];


Pssm-ID: 440656 [Multi-domain]  Cd Length: 767  Bit Score: 60.64  E-value: 4.12e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  793 VNHQGLSAASTISFNLPTGKSLSDASAAIDRAMTQL------GVPSTVRGSFAGTAQVFQETMNSQVILIIAAIATVYIV 866
Cdd:COG1033    155 VSPDGKATLIVVTLDPDPLSSDLDRKEVVAEIRAIIakyedpGVEVYLTGFPVLRGDIAEAIQSDLAIFFPLALLLILLL 234
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  867 LGILYESyvhPLTILSTLPSAGVGALLAL---ELFNAPFSLIALIGIMLLIGIVKKNAIMMVDFALEAQRHGnLTPQEAI 943
Cdd:COG1033    235 LFLFFRS---LRGVLLPLLVVLLAVIWTLglmGLLGIPLSPLTILVPPLLLAIGIDYGIHLLNRYREERRKG-LDKREAL 310
                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1425910443  944 FQACLLRFRPIMMTTLAALFGALPLVLSGgdgSELRQPLGITIVGGLVMSQLLTLYTTPVVYLFFDRLRLRFSRKPK 1020
Cdd:COG1033    311 REALRKLGPPVLLTSLTTAIGFLSLLFSD---IPPIRDFGIVAAIGVLLAFLTSLTLLPALLSLLPRPKPKTRRLKK 384
2A0601 TIGR00914
heavy metal efflux pump, CzcA family; This model represents a family of H+/heavy metal cation ...
154-499 8.99e-09

heavy metal efflux pump, CzcA family; This model represents a family of H+/heavy metal cation antiporters. This family is one of several subfamilies within the scope of pfam00873. [Cellular processes, Detoxification, Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 129992 [Multi-domain]  Cd Length: 1051  Bit Score: 59.77  E-value: 8.99e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  154 LYDFAST--QLAPTISQIDGVADVDVGGSS-LPAVRVGLNPQALFNQGVSLDDVRTAVSNANVRKPQGALEDGTHRWQI- 229
Cdd:TIGR00914  693 LDDLDATaeKISAVLKGVPGAADVKVEQTTgLPYLTVEIDREKAARYGLTVGDVQDTVATAVGGRMSGETFEGDRRFDIv 772
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  230 ----QTNDELKTAAEYQPLIIHYNNGGA---VRLGDVATVtDSVQDVRNAGMTNAKPAILLmirklpEAN-----IIQTV 297
Cdd:TIGR00914  773 irlpESLRESPQALRQLPIPLPLSEDARkqfIPLSDVADL-RVSPGPNQISRENGKRRVVV------SANvrgrdLGSFV 845
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  298 DSIRAKLPElQETIPAAIDL----QIAQDRSPTIRASLeeveqtlIISVALVILVVFLFLRSGRA--TIIPAVSVPVSLI 371
Cdd:TIGR00914  846 DDAKKAIAE-QVKLPPGYWItwggQFEQLQSATKRLQI-------VVPVTLLLIFVLLYAAFGNVkdALLVFTGIPFALT 917
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  372 GTFAAMYLCGFSlnnlslMALTIATGFV------VDDAIVVLENIARHLEAGMKPLQAALQGT----REVGFTVLSMSLS 441
Cdd:TIGR00914  918 GGVFALWLRGIP------LSISAAVGFIalsgvaVLNGLVMISFIRKLLEEGPSLDEAVYEGAltrvRPVLMTALVASLG 991
                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1425910443  442 LVAVflplLLMGGLPGRLLREFAVTLSVAIGISLLVSLTLTPMMCGWMLKASKPREQK 499
Cdd:TIGR00914  992 FVPM----AIATGTGAEVQRPLATVVIGGIITATLLTLFVLPALYRLVHRRRHKGRKE 1045
YdfJ COG2409
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function ...
295-631 9.43e-09

Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function prediction only];


Pssm-ID: 441964 [Multi-domain]  Cd Length: 697  Bit Score: 59.39  E-value: 9.43e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  295 QTVDSIRAKLPELQE-------TIPAAIDLQIAQdrsptirASLEEVEQTLIISVALVILVVFLFLRSGRATIIPAVSVP 367
Cdd:COG2409    132 EAVDALRDAVAAAPApgltvyvTGPAALAADLNE-------AFEEDLGRAELITLPVALVVLLLVFRSLVAALLPLLTAG 204
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  368 VSLIGTFAAMYLCGFSLNnLSLMALTIATGFV----VDDAIVVlenIARH---LEAGMKPLQA---ALQGTREV----GF 433
Cdd:COG2409    205 LAVGVALGLLALLAAFTD-VSSFAPNLLTMLGlgvgIDYALFL---VSRYreeLRAGEDREEAvarAVATAGRAvlfsGL 280
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  434 TV----LSMSLSLVAVFlplllmgglpgrllREFAVTLSVAIGISLLVSLTLTPMMCG----WMLKASKPREQKRLRGFG 505
Cdd:COG2409    281 TVaialLGLLLAGLPFL--------------RSMGPAAAIGVAVAVLAALTLLPALLAllgrRVFWPRRPRRRRAAAPES 346
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  506 RMlvalqqgYGKSLKWVLNHTRLVGVV------LLGTIALNIWLYISIPKTF----------------FPEQDTGVLMGG 563
Cdd:COG2409    347 GF-------WRRLARAVVRRPVPVLVAavavllALALPALGLRLGLPDADSLpadspsrqgydalaehFPPGSNGPLTVV 419
                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1425910443  564 IQADQSISfQAMRGKLQDFMKIIRDDPAVDNVTGFTGGSRVNSGMMFITLKPRDE-RSETAQQIIDRLR 631
Cdd:COG2409    420 VESDDDLD-PADLAALDALAAALAAVPGVASVQPPTRPEGTDGDAARLQVVPDGDpDSPEAIDLVDRLR 487
2A067 TIGR00921
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ...
816-1012 3.22e-08

The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273340 [Multi-domain]  Cd Length: 719  Bit Score: 57.54  E-value: 3.22e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  816 DASAAIDRAMTQLGVPSTVRGSFAGTAQVFQETMNSQVILIIAAIATVYIVLGILYESYVHPLTILSTLPSAGVGALLAL 895
Cdd:TIGR00921  159 DVERSLERTNPPSGKFLDVTGSPAINYDIEREFGKDMGTTMAISGILVVLVLLLDFKRWWRPLLPLVIILFGVAWVLGIM 238
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  896 ELFNAPFSLIALIGIMLLIGIVKKNAIMMVDfALEAQRHGNLTPQEAIFQACLLRFRPIMMTTLAALFGALPLVLSggdG 975
Cdd:TIGR00921  239 GWLGIPLYATTLLAVPMLIGVGIDYGIQTLN-RYEEERDIGRAKGEAIVTAVRRTGRAVLIALLTTSAGFAALALS---E 314
                          170       180       190
                   ....*....|....*....|....*....|....*..
gi 1425910443  976 SELRQPLGITIVGGLVMSQLLTLYTTPVVYLFFDRLR 1012
Cdd:TIGR00921  315 FPMVSEFGLGLVAGLITAYLLTLLVLPALLQSIDIGR 351
2A067 TIGR00921
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ...
324-483 3.86e-07

The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273340 [Multi-domain]  Cd Length: 719  Bit Score: 54.07  E-value: 3.86e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  324 SPTIRASLEEVEQ-----TLIISVALVILVVFLFLRSGRATIIPAVSVPVSLIGTFAAMYLCGFSLNNLSLMALTIATGF 398
Cdd:TIGR00921  180 SPAINYDIEREFGkdmgtTMAISGILVVLVLLLDFKRWWRPLLPLVIILFGVAWVLGIMGWLGIPLYATTLLAVPMLIGV 259
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  399 VVDDAIVVLENIARHLEAGMKPLQAALQGTREVGFTVLSMSLSLVAVFlplLLMGGLPGRLLREFAVTLSVAIGISLLVS 478
Cdd:TIGR00921  260 GIDYGIQTLNRYEEERDIGRAKGEAIVTAVRRTGRAVLIALLTTSAGF---AALALSEFPMVSEFGLGLVAGLITAYLLT 336

                   ....*
gi 1425910443  479 LTLTP 483
Cdd:TIGR00921  337 LLVLP 341
PRK13023 PRK13023
protein translocase subunit SecDF;
292-502 3.95e-06

protein translocase subunit SecDF;


Pssm-ID: 171842 [Multi-domain]  Cd Length: 758  Bit Score: 50.77  E-value: 3.95e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  292 NIIQTVDSIRAKLPELQETIPAAIDLQIAQDRSPTIRASL------------------EEVEQTLIISVALVILVV--FL 351
Cdd:PRK13023   216 NQVVSAPTVSGPLDTSELQIEGAFDLQAANNMAVVLRSGAlpqavtvleertiasalgEDYASAAVLAALLAALVVglFM 295
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  352 FLRSGRATIIPAVSVPVSLIGTFAAMYLCGFSLNNLSLMALTIATGFVVDDAIVVLENIARHLEAGMKPLQAALQGTREV 431
Cdd:PRK13023   296 VLSYGILGVIALVALVVNIIILTAVLSLIGASISLASIAGLVLTIGLAVDAHILIYERVREDRRKGYSVVQAMESGFYRA 375
                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1425910443  432 GFTVLSMSLSlvaVFLPLLLMGGLPGRLLREFAVTLSVAIGISLLVSLTLTPMMCGWMLKASKPREQKRLR 502
Cdd:PRK13023   376 LSTIVDANLT---TLIAALVLFLLGSGTVHGFALTVAIGIGTTLFTTLTFTRLLIAQWVRTAKPKEVPKRR 443
SecD COG0342
Preprotein translocase subunit SecD [Intracellular trafficking, secretion, and vesicular ...
314-497 2.20e-04

Preprotein translocase subunit SecD [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 440111 [Multi-domain]  Cd Length: 434  Bit Score: 44.72  E-value: 2.20e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  314 AIDLQIAQDR--SPT-----IRASLeeveQTLIISVALVILVVFLFLRsgRATIIPAVSVPVSLIGTFAAMYLCGFslnN 386
Cdd:COG0342    250 PAPLEIVEERtvGPTlgadsIEKGL----IAGLIGLLLVALFMLLYYR--LPGLVANIALALNVVLLLGVLSLLGA---T 320
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  387 LSL-----MALTIATGfvVDDAIVVLENIARHLEAGmKPLQAALqgtrEVGF-------------TVLSMS----LSLVA 444
Cdd:COG0342    321 LTLpgiagIILTIGMA--VDANVLIFERIREELRAG-RSLRAAI----EAGFkrafstildanvtTLIAAVvlfvLGTGP 393
                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1425910443  445 VflplllmgglpgrllREFAVTLSVAIGISLLVSLTLTPMMCGWMLKASKPRE 497
Cdd:COG0342    394 V---------------KGFAVTLILGILISMFTAVPVTRPLLNLLLGRRRLKK 431
MMPL pfam03176
MMPL family; Members of this family are putative integral membrane proteins from bacteria. ...
312-501 4.29e-04

MMPL family; Members of this family are putative integral membrane proteins from bacteria. Several of the members are mycobacterial proteins. Many of the proteins contain two copies of this aligned region. The function of these proteins is not known, although it has been suggested that they may be involved in lipid transport.


Pssm-ID: 308676 [Multi-domain]  Cd Length: 332  Bit Score: 43.82  E-value: 4.29e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  312 PAAI--DLQIAQDRSPTIrasleeveqTLIISVALVILVVFLFLRSGRATIIPAVSVPVSLIGTFAAM----YLCGFSLN 385
Cdd:pfam03176  129 PAATvaDLRDAGDRDLGL---------IEAVTLVVIFIILLIVYRSVVAALLPLLTVGLSLGAAQGLVailaHILGIGLS 199
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  386 NLS---LMALTIATGfvVDDAIVVLENIARHLEAGMKPLQAALQGTREVG-----------FTVLSMSLSLVAVFlplll 451
Cdd:pfam03176  200 TFAlnlLVVLLIAVG--TDYALFLVSRYREELRAGEDREEAVIRAVRGTGkvvtaagltvaIAMLALSFARLPVF----- 272
                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1425910443  452 mgglpgrllREFAVTLSVAIGISLLVSLTLTPMMCG----WMLKASKPREQKRL 501
Cdd:pfam03176  273 ---------AQVGPTIAIGVLVDVLAALTLLPALLAllgrWGLWPPKRDRTARW 317
MMPL pfam03176
MMPL family; Members of this family are putative integral membrane proteins from bacteria. ...
786-1019 1.80e-03

MMPL family; Members of this family are putative integral membrane proteins from bacteria. Several of the members are mycobacterial proteins. Many of the proteins contain two copies of this aligned region. The function of these proteins is not known, although it has been suggested that they may be involved in lipid transport.


Pssm-ID: 308676 [Multi-domain]  Cd Length: 332  Bit Score: 41.89  E-value: 1.80e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  786 PANAPLSVNHQGLSAASTISFNLPTGKSLSDAS-AAIDRAMTQLGVPSTVRGSFAGTAQVFQETMNSQ----VILIIAAI 860
Cdd:pfam03176   73 PDTAALFVSPDGKAAYVVVTLEGDPGTTEADESvAAVRDAVEQAPPPEGLKAYLTGPAATVADLRDAGdrdlGLIEAVTL 152
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  861 ATVYIVLGILYESYVHPLTILSTLpSAGVGALLALELFNAPFSLIAL------IGIMLLIGIVKKNAIMMVDFALEAQRH 934
Cdd:pfam03176  153 VVIFIILLIVYRSVVAALLPLLTV-GLSLGAAQGLVAILAHILGIGLstfalnLLVVLLIAVGTDYALFLVSRYREELRA 231
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  935 GnLTPQEAIFQAcllrfrpiMMTTLAALFGA--------LPLVLsggdgSELR--QPLGITIVGGLVMSQLLTLYTTPVV 1004
Cdd:pfam03176  232 G-EDREEAVIRA--------VRGTGKVVTAAgltvaiamLALSF-----ARLPvfAQVGPTIAIGVLVDVLAALTLLPAL 297
                          250
                   ....*....|....*
gi 1425910443 1005 YLFFDRLRLRFSRKP 1019
Cdd:pfam03176  298 LALLGRWGLWPPKRD 312
PRK13024 PRK13024
bifunctional preprotein translocase subunit SecD/SecF; Reviewed
329-641 2.51e-03

bifunctional preprotein translocase subunit SecD/SecF; Reviewed


Pssm-ID: 237276 [Multi-domain]  Cd Length: 755  Bit Score: 41.76  E-value: 2.51e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  329 ASLEEVEQTL-------------IIS--VALVILVVFLFLRSGRATIIPAVSVPVSLIGTFAAMYLCGFSLNNLSLMALT 393
Cdd:PRK13024   246 APLKIIESRSvgptlgqdaidagIIAgiIGFALIFLFMLVYYGLPGLIANIALLLYIFLTLGALSSLGAVLTLPGIAGLV 325
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  394 IATGFVVDDAIVVLENIARHLEAGMKPLQAALQGTREVGFTVLSMSL-SLVA-----VFLPLLLmgglpgrllREFAVTL 467
Cdd:PRK13024   326 LGIGMAVDANVLIFERIKEELRKGKSLKKAFKKGFKNAFSTILDSNItTLIAaailfFFGTGPV---------KGFATTL 396
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  468 SVAIGISLLVSLTLTPMMCGWMLKaskpREQKRLRGFGR---MLVALQQGYGKSLKWVLNHTRLVGVVLLGTIALniwly 544
Cdd:PRK13024   397 IIGILASLFTAVFLTRLLLELLVK----RGDKKPFLFGVkkkKIHNINEGVTIFDRIDFVKKRKWFLIFSIVLVI----- 467
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1425910443  545 ISIPKTFFPEQDTGV-LMGG----IQADQSISFQAMRGKLqdfmkiirDDPAVDNVTGFTGGSRVNSGMmfITLKPRDER 619
Cdd:PRK13024   468 AGIIIFFIFGLNLGIdFTGGtryeIRTDQPVDLEQVRADL--------KELGLGEVNIVTFGSDNNQVL--VRTYGILSD 537
                          330       340
                   ....*....|....*....|...
gi 1425910443  620 SETAQQ-IIDRLRVKLAKEPGAN 641
Cdd:PRK13024   538 DEEADTeIVAKLKNALKNDKGGT 560
COG4258 COG4258
Predicted exporter [General function prediction only];
338-404 6.65e-03

Predicted exporter [General function prediction only];


Pssm-ID: 443400 [Multi-domain]  Cd Length: 783  Bit Score: 40.61  E-value: 6.65e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1425910443  338 LIISVALVILVVFLFLRSGRATIIpaVSVPV--SLIGTFAAMYLCGFSLNNLSLMALTIATGFVVDDAI 404
Cdd:COG4258    645 LLLALLLILLLLLLRLRSLRRALR--VLLPPllAVLLTLAILGLLGIPLNLFHLIALLLVLGIGIDYAL 711
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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