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Conserved domains on  [gi|1426492350|ref|WP_113286504|]
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GntR family transcriptional regulator [Neorhizobium sp. 2083]

Protein Classification

GntR family transcriptional regulator( domain architecture ID 11448455)

GntR-family transcriptional regulator is one of a group of transcriptional regulators with a conserved N-terminal helix-turn-helix DNA-binding domain and a diverse C-terminal effector-binding and oligomerization domain; controls the expression of genes with diverse biological functions

CATH:  1.10.10.10
Gene Ontology:  GO:0003700|GO:0003677
PubMed:  33509775
SCOP:  4000155

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GntR COG1802
DNA-binding transcriptional regulator, GntR family [Transcription];
5-215 2.35e-31

DNA-binding transcriptional regulator, GntR family [Transcription];


:

Pssm-ID: 441407 [Multi-domain]  Cd Length: 222  Bit Score: 114.63  E-value: 2.35e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1426492350   5 SDNLVDAIYADLRQKLQRSAVSPSDRLVDTEIANARGISRMPAREALLRLVSEGYLV-GTTRGFAVRELSLEDISGLFEV 83
Cdd:COG1802     9 RESLAEQVYEALREAILSGELPPGERLSEAELAERLGVSRTPVREALRRLEAEGLVEiRPNRGARVAPLSPEEIRELYEV 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1426492350  84 RRQLEPRAAACAARDMTPEIEAEITAAMNRVERALGESDIPALLAANVDFRNAWLKAVSNPHMAATISRFIDYFQSVRLG 163
Cdd:COG1802    89 RAALEGLAARLAAERATPADLARLRALLEELEAAAAAGDVAAYLELDREFHRALVEAAGNPRLAELLRRLRARLRRYRRL 168

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1426492350 164 TFADPGTAELYIDGLSRIHAAFLARDPLMVQDRMTLFMFAAEEAYLSVRRRQ 215
Cdd:COG1802   169 SLRSPGRLEESLAEHRAILDALEAGDAEAAAAALRAHLERARERLLEALAAA 220
 
Name Accession Description Interval E-value
GntR COG1802
DNA-binding transcriptional regulator, GntR family [Transcription];
5-215 2.35e-31

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441407 [Multi-domain]  Cd Length: 222  Bit Score: 114.63  E-value: 2.35e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1426492350   5 SDNLVDAIYADLRQKLQRSAVSPSDRLVDTEIANARGISRMPAREALLRLVSEGYLV-GTTRGFAVRELSLEDISGLFEV 83
Cdd:COG1802     9 RESLAEQVYEALREAILSGELPPGERLSEAELAERLGVSRTPVREALRRLEAEGLVEiRPNRGARVAPLSPEEIRELYEV 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1426492350  84 RRQLEPRAAACAARDMTPEIEAEITAAMNRVERALGESDIPALLAANVDFRNAWLKAVSNPHMAATISRFIDYFQSVRLG 163
Cdd:COG1802    89 RAALEGLAARLAAERATPADLARLRALLEELEAAAAAGDVAAYLELDREFHRALVEAAGNPRLAELLRRLRARLRRYRRL 168

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1426492350 164 TFADPGTAELYIDGLSRIHAAFLARDPLMVQDRMTLFMFAAEEAYLSVRRRQ 215
Cdd:COG1802   169 SLRSPGRLEESLAEHRAILDALEAGDAEAAAAALRAHLERARERLLEALAAA 220
PRK11414 PRK11414
GntR family transcriptional regulator;
15-174 5.71e-16

GntR family transcriptional regulator;


Pssm-ID: 183126 [Multi-domain]  Cd Length: 221  Bit Score: 74.14  E-value: 5.71e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1426492350  15 DLRQKLQRSAVSPSDRLVDTEIANARGISRMPAREALLRLVSEGYL-VGTTRGFAVRELSLEDISGLFEVRRQLEPRAAA 93
Cdd:PRK11414   19 DLKHQLSIGALKPGARLITKNLAEQLGMSITPVREALLRLVSVNALsVAPAQAFTVPEVSKRQLDEINRIRYELELMAVA 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1426492350  94 CAARDMTPEIEAEITAAMNRVERALGESDIPALLAANVDFRNAWLKAVSNPHMAATISRFIdyfqsVRLGtfadPGTAEL 173
Cdd:PRK11414   99 LAVENLTPQDLAELQELLEKLQQAQEKGDMEQIINANRLFRLAIYHRSNMPILCEMIEQLW-----VRMG----PSLHYL 169


                  .
gi 1426492350 174 Y 174
Cdd:PRK11414  170 Y 170
FCD pfam07729
FCD domain; This domain is the C-terminal ligand binding domain of many members of the GntR ...
 80-198 4.01e-12

FCD domain; This domain is the C-terminal ligand binding domain of many members of the GntR family. This domain binds to a range of effector molecules, including Lactate, Zn(II), Ni(II), Ca(II), Mg(II), citrate, sugar acids, sialic acid and N-acetylglucosamine-6-P, that regulate the transcription of genes through the action of the N-terminal DNA-binding domain pfam00392 (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043). This domain is found in Swiss:P45427 and Swiss:P31460 that are regulators of sugar biosynthesis operons. It is also in the known structure of FadR where it binds to acyl-coA, the domain is alpha helical. This family has been named as FCD for (FadR C-terminal Domain).


Pssm-ID: 429623 [Multi-domain]  Cd Length: 121  Bit Score: 61.23  E-value: 4.01e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1426492350  80 LFEVRRQLEPRAAACAARDMTPEIEAEITAAMNRVERALGESDIPALLAANVDFRNAWLKAVSNPHMAATISRFIDYFQS 159
Cdd:pfam07729   2 LYELRAALEPLAARLAAERATDEDLAELEALLEALEAAADAGDLEAFAEADREFHLALAEAAGNPVLARMLESLWDRLRR 81

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1426492350 160 VRLGTFADPGTAELYIDGLSRIHAAFLARDPLMVQDRMT 198
Cdd:pfam07729  82 LRRLLLSSPGRLRASLEEHRAILDAIRARDPEAARAAMR 120
FCD smart00895
This entry represents the C-terminal ligand binding domain of many members of the GntR family; ...
 80-197 5.53e-07

This entry represents the C-terminal ligand binding domain of many members of the GntR family; This domain probably binds to a range of effector molecules that regulate the transcription of genes through the action of the N-terminal DNA-binding domain. This domain is found in and that are regulators of sugar biosynthesis operons. Many bacterial transcription regulation proteins bind DNA through a helix-turn-helix (HTH) motif, which can be classified into subfamilies on the basis of sequence similarities. The HTH GntR family has many members distributed among diverse bacterial groups that regulate various biological processes. It was named GntR after the Bacillus subtilis repressor of the gluconate operon. In general, these proteins contain a DNA-binding HTH domain at the N terminus, and an effector binding or oligomerisation domain at the C terminus. The winged-helix DNA-binding domain is well conserved in structure for the whole of the GntR family, and is similar in structure to other transcriptional regulator families. The C-terminal effector-binding and oligomerisation domains are more variable and are consequently used to define the subfamilies. Based on the sequence and structure of the C-terminal domains, the GtnR family can be divided into four major groups, as represented by FadR, HutC, MocR and YtrA, as well as some minor groups such as those represented by AraR and PlmA.


Pssm-ID: 214892 [Multi-domain]  Cd Length: 123  Bit Score: 46.97  E-value: 5.53e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1426492350   80 LFEVRRQLEPRAAACAARDMTPEIEAEITAAMNRVERALGESD-IPALLAANVDFRNAWLKAVSNPHMAATISRFIDYFQ 158
Cdd:smart00895   2 LYEVRRALEPLAARLAAERATDEDLAALEALLDAMEAAAAAGDdLEEFAELDREFHRALAEAAGNPVLLELLESLRARLR 81

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 1426492350  159 SVRLGTFADPGTAelyIDGLSRIHAAFLARDPLMVQDRM 197
Cdd:smart00895  82 RLRRLSLEAARRA---LDEHRAILDAIRARDAEAARAAM 117
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 8-61 2.31e-06

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 43.98  E-value: 2.31e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1426492350   8 LVDAIYADLRQKLQRSAVSPSDRLVDT-EIANARGISRMPAREALLRLVSEGYLV 61
Cdd:cd07377     2 LYEQIADQLREAILSGELKPGDRLPSErELAEELGVSRTTVREALRELEAEGLVE 56
 
Name Accession Description Interval E-value
GntR COG1802
DNA-binding transcriptional regulator, GntR family [Transcription];
5-215 2.35e-31

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441407 [Multi-domain]  Cd Length: 222  Bit Score: 114.63  E-value: 2.35e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1426492350   5 SDNLVDAIYADLRQKLQRSAVSPSDRLVDTEIANARGISRMPAREALLRLVSEGYLV-GTTRGFAVRELSLEDISGLFEV 83
Cdd:COG1802     9 RESLAEQVYEALREAILSGELPPGERLSEAELAERLGVSRTPVREALRRLEAEGLVEiRPNRGARVAPLSPEEIRELYEV 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1426492350  84 RRQLEPRAAACAARDMTPEIEAEITAAMNRVERALGESDIPALLAANVDFRNAWLKAVSNPHMAATISRFIDYFQSVRLG 163
Cdd:COG1802    89 RAALEGLAARLAAERATPADLARLRALLEELEAAAAAGDVAAYLELDREFHRALVEAAGNPRLAELLRRLRARLRRYRRL 168

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1426492350 164 TFADPGTAELYIDGLSRIHAAFLARDPLMVQDRMTLFMFAAEEAYLSVRRRQ 215
Cdd:COG1802   169 SLRSPGRLEESLAEHRAILDALEAGDAEAAAAALRAHLERARERLLEALAAA 220
PRK11414 PRK11414
GntR family transcriptional regulator;
15-174 5.71e-16

GntR family transcriptional regulator;


Pssm-ID: 183126 [Multi-domain]  Cd Length: 221  Bit Score: 74.14  E-value: 5.71e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1426492350  15 DLRQKLQRSAVSPSDRLVDTEIANARGISRMPAREALLRLVSEGYL-VGTTRGFAVRELSLEDISGLFEVRRQLEPRAAA 93
Cdd:PRK11414   19 DLKHQLSIGALKPGARLITKNLAEQLGMSITPVREALLRLVSVNALsVAPAQAFTVPEVSKRQLDEINRIRYELELMAVA 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1426492350  94 CAARDMTPEIEAEITAAMNRVERALGESDIPALLAANVDFRNAWLKAVSNPHMAATISRFIdyfqsVRLGtfadPGTAEL 173
Cdd:PRK11414   99 LAVENLTPQDLAELQELLEKLQQAQEKGDMEQIINANRLFRLAIYHRSNMPILCEMIEQLW-----VRMG----PSLHYL 169


                  .
gi 1426492350 174 Y 174
Cdd:PRK11414  170 Y 170
FadR COG2186
DNA-binding transcriptional regulator, FadR family [Transcription];
7-215 1.90e-14

DNA-binding transcriptional regulator, FadR family [Transcription];


Pssm-ID: 441789 [Multi-domain]  Cd Length: 232  Bit Score: 69.96  E-value: 1.90e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1426492350   7 NLVDAIYADLRQKLQRSAVSPSDRL-VDTEIANARGISRMPAREALLRLVSEGYL-----VGTT-----------RGFAV 69
Cdd:COG2186     7 SLAEQVAEQLRELILSGELKPGDRLpSERELAEQLGVSRTTVREALRALEALGLVevrqgGGTFvrepspwalldPLALL 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1426492350  70 RELSLEDISGLFEVRRQLEPRAAACAARDMTPEIEAEITAAMNRVERALGesDIPALLAANVDFRNAWLKAVSNPHMAAT 149
Cdd:COG2186    87 LALDDASLRDLLEARLALEPEAARLAAERATDEDLARLEAALAEMEAAAD--DGEAFAEADLAFHRAIAEASGNPLLALL 164

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1426492350 150 ISRFIDYFQSVRLGTFADPGTAELYIDGLSRIHAAFLARDPLMVQDRMTLFMFAAEEAYLSVRRRQ 215
Cdd:COG2186   165 LESLRELLRRSVRLTLRSPEARERSLAEHRAILDAIRAGDPEAARAAMRAHLEAVRERLREALAER 230
FCD pfam07729
FCD domain; This domain is the C-terminal ligand binding domain of many members of the GntR ...
 80-198 4.01e-12

FCD domain; This domain is the C-terminal ligand binding domain of many members of the GntR family. This domain binds to a range of effector molecules, including Lactate, Zn(II), Ni(II), Ca(II), Mg(II), citrate, sugar acids, sialic acid and N-acetylglucosamine-6-P, that regulate the transcription of genes through the action of the N-terminal DNA-binding domain pfam00392 (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043). This domain is found in Swiss:P45427 and Swiss:P31460 that are regulators of sugar biosynthesis operons. It is also in the known structure of FadR where it binds to acyl-coA, the domain is alpha helical. This family has been named as FCD for (FadR C-terminal Domain).


Pssm-ID: 429623 [Multi-domain]  Cd Length: 121  Bit Score: 61.23  E-value: 4.01e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1426492350  80 LFEVRRQLEPRAAACAARDMTPEIEAEITAAMNRVERALGESDIPALLAANVDFRNAWLKAVSNPHMAATISRFIDYFQS 159
Cdd:pfam07729   2 LYELRAALEPLAARLAAERATDEDLAELEALLEALEAAADAGDLEAFAEADREFHLALAEAAGNPVLARMLESLWDRLRR 81

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1426492350 160 VRLGTFADPGTAELYIDGLSRIHAAFLARDPLMVQDRMT 198
Cdd:pfam07729  82 LRRLLLSSPGRLRASLEEHRAILDAIRARDPEAARAAMR 120
FCD smart00895
This entry represents the C-terminal ligand binding domain of many members of the GntR family; ...
 80-197 5.53e-07

This entry represents the C-terminal ligand binding domain of many members of the GntR family; This domain probably binds to a range of effector molecules that regulate the transcription of genes through the action of the N-terminal DNA-binding domain. This domain is found in and that are regulators of sugar biosynthesis operons. Many bacterial transcription regulation proteins bind DNA through a helix-turn-helix (HTH) motif, which can be classified into subfamilies on the basis of sequence similarities. The HTH GntR family has many members distributed among diverse bacterial groups that regulate various biological processes. It was named GntR after the Bacillus subtilis repressor of the gluconate operon. In general, these proteins contain a DNA-binding HTH domain at the N terminus, and an effector binding or oligomerisation domain at the C terminus. The winged-helix DNA-binding domain is well conserved in structure for the whole of the GntR family, and is similar in structure to other transcriptional regulator families. The C-terminal effector-binding and oligomerisation domains are more variable and are consequently used to define the subfamilies. Based on the sequence and structure of the C-terminal domains, the GtnR family can be divided into four major groups, as represented by FadR, HutC, MocR and YtrA, as well as some minor groups such as those represented by AraR and PlmA.


Pssm-ID: 214892 [Multi-domain]  Cd Length: 123  Bit Score: 46.97  E-value: 5.53e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1426492350   80 LFEVRRQLEPRAAACAARDMTPEIEAEITAAMNRVERALGESD-IPALLAANVDFRNAWLKAVSNPHMAATISRFIDYFQ 158
Cdd:smart00895   2 LYEVRRALEPLAARLAAERATDEDLAALEALLDAMEAAAAAGDdLEEFAELDREFHRALAEAAGNPVLLELLESLRARLR 81

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 1426492350  159 SVRLGTFADPGTAelyIDGLSRIHAAFLARDPLMVQDRM 197
Cdd:smart00895  82 RLRRLSLEAARRA---LDEHRAILDAIRARDAEAARAAM 117
GntR pfam00392
Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the ...
 8-61 1.71e-06

Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the N-terminal HTH region of GntR-like bacterial transcription factors. At the C-terminus there is usually an effector-binding/oligomerization domain. The GntR-like proteins include the following sub-families: MocR, YtrR, FadR, AraR, HutC and PlmA, DevA, DasR. Many of these proteins have been shown experimentally to be autoregulatory, enabling the prediction of operator sites and the discovery of cis/trans relationships. The DasR regulator has been shown to be a global regulator of primary metabolism and development in Streptomyces coelicolor.


Pssm-ID: 306822 [Multi-domain]  Cd Length: 64  Bit Score: 44.14  E-value: 1.71e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1426492350   8 LVDAIYADLRQKLQRSAVSPSDRL-VDTEIANARGISRMPAREALLRLVSEGYLV 61
Cdd:pfam00392   1 LYEQVYARLREDILSGRLRPGDKLpSERELAAEFGVSRTTVREALRRLEAEGLVE 55
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 8-61 2.31e-06

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 43.98  E-value: 2.31e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1426492350   8 LVDAIYADLRQKLQRSAVSPSDRLVDT-EIANARGISRMPAREALLRLVSEGYLV 61
Cdd:cd07377     2 LYEQIADQLREAILSGELKPGDRLPSErELAEELGVSRTTVREALRELEAEGLVE 56
HTH_GNTR smart00345
helix_turn_helix gluconate operon transcriptional repressor;
12-61 1.81e-05

helix_turn_helix gluconate operon transcriptional repressor;


Pssm-ID: 197669 [Multi-domain]  Cd Length: 60  Bit Score: 41.41  E-value: 1.81e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1426492350   12 IYADLRQKLQRSAVSPSDRLVDT-EIANARGISRMPAREALLRLVSEGYLV 61
Cdd:smart00345   1 VAERLREDIVSGELRPGDKLPSErELAAQLGVSRTTVREALSRLEAEGLVQ 51
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
12-61 2.67e-03

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 37.92  E-value: 2.67e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1426492350  12 IYADLRQKLQRSAVSPSDRL-VDTEIANARGISRMPAREALLRLVSEGYLV 61
Cdd:COG2188    10 IADALRERIESGELPPGDRLpSERELAEEFGVSRMTVRKALDELVEEGLLE 60
PRK11402 PRK11402
transcriptional regulator PhoB;
12-61 3.25e-03

transcriptional regulator PhoB;


Pssm-ID: 183118 [Multi-domain]  Cd Length: 241  Bit Score: 37.89  E-value: 3.25e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1426492350  12 IYADLRQKL----QRSAVSPSDRL-VDTEIANARGISRMPAREALLRLVSEGYLV 61
Cdd:PRK11402   10 LYATVRQRLlddiAQGVYQAGQQIpTENELCTQYNVSRITIRKAISDLVADGVLI 64
PRK11534 PRK11534
DNA-binding transcriptional regulator CsiR; Provisional
 1-115 5.21e-03

DNA-binding transcriptional regulator CsiR; Provisional


Pssm-ID: 183181 [Multi-domain]  Cd Length: 224  Bit Score: 37.18  E-value: 5.21e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1426492350   1 MLKLSDNLVDAIYADLRQKLQRSAVSPSDRLVDTEIANARGISRMPAREALLRLVSEGYL-VGTTRGFAVRELSLEDISG 79
Cdd:PRK11534    1 MTAPMQITALDGYRWLKNDIIRGNFQPDEKLRMSLLTSRYALGVGPLREALSQLVAERLVtVVNQKGYRVASMSEQELLD 80

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1426492350  80 LFEVRRQLEPRAAACAARDMTPEIEAEITA---AMNRVE 115
Cdd:PRK11534   81 IFDARANMEAMLVSLAIARGGDEWEADVLAkahLLSKLE 119
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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