|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
12-413 |
7.88e-36 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 135.48 E-value: 7.88e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435803813 12 AWAIAIACVAFYAIPLGVVANqAGLFATPVMEEFGWSRTDATLYMTIQPWVAAICTPFAGKLISRFNPRWVMTAAAAVFG 91
Cdd:cd17355 1 GWVVLAVTFLILILSWGIRYY-FGVFIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435803813 92 LASLACAWFTEPWQWNV-YGVLYGASAAFWMYIATPTFINRWFAKSNGTVIGTIGVCASLIGAFMSPVIQGWISGYGWHT 170
Cdd:cd17355 80 AGLVLLALATSLWQLYLlWGLLGGGGAGTLAAVAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRT 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435803813 171 ARIIISVIALVASVVLTAALLREspekmgvlPWGYGSAEVAAAKsdaksvievSADEGVTAAQARKNPALWLLIImaGFF 250
Cdd:cd17355 160 ALLVLALLALLVLVPVLLLLRRR--------PADLALRAYDDAS---------PASPGSTLKEALRSASFWLLAL--AFF 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435803813 251 VVAA---GMMQQFSSYASTGALGAAVGALGVTVCMIGQLFGKFGLGWLCDHTGARISGVVASIFGALGIAIVLFSVDSAM 327
Cdd:cd17355 221 LCGFavvGLIVHLVPYLADRGISPAAAAVALALIGLFNIVGRLLSGWLGDRYSPRRLLAASYALRALGLALLLLLPFPPL 300
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435803813 328 MFYVGVFLFGIGFAALNIVPPMACRQAFGQKDYANIFSMVATGLNVFSGFSAIIYAQIFDITGSFAGCFWLIIGFYVVTL 407
Cdd:cd17355 301 ALLLFAALFGLGWGATVPLTAALAARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTGSYTAAWALAVALGLIAA 380
|
....*.
gi 1435803813 408 ICSLVI 413
Cdd:cd17355 381 LLVLPI 386
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
35-422 |
3.98e-31 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 122.68 E-value: 3.98e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435803813 35 GLFATPVMEEFGWSRTDATLYMTIQPWVAAICTPFAGKLISRFNPRWVMTAAAAVFGLASLACAWFTEPWQWNVYGVLYG 114
Cdd:COG2223 25 SVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAVSYWLLLLLGLLLG 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435803813 115 ASAAFwMYIATPTFINRWFAKSN-GTVIGTIGVCASLIGAFMSPVIQGWISGYGWHTArIIISVIALVASVVLTAALLRE 193
Cdd:COG2223 105 IGGGG-SFAVGIALVSKWFPPDRrGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNA-FLILGILLLVVAVLAWLFLRD 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435803813 194 SPEKMGvlpwgygsaevaaaksdaksviEVSADEGVTAAQARKNPALWLL-IIMAGFFVVAAGMMQQFSSYASTGA-LGA 271
Cdd:COG2223 183 PPAGAA----------------------AAAKASLRDQLEALRDPRFWLLsLLYFGTFGSFIGFSSWLPPYLVDQFgLSA 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435803813 272 AVGALGVTVCMIGQLFGKFGLGWLCDHTGARISGVVASIFGALGIAIVLFSVDSAMMFYVGVFLFGIGFAALNIVPPMAC 351
Cdd:COG2223 241 ATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALGSLWLFLVLFLLLGLALGGGNGAVFALV 320
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1435803813 352 RQAFGQKDYANIFSMVATGLNVFSGFSAIIYAQIFDITGSFAGCFWLIIGFYVVTLICSLVIVPMGRRSWA 422
Cdd:COG2223 321 PDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYTAAFLVFAVLALVALVLTLLLYRRPRRAAA 391
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
3-413 |
8.67e-28 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 113.43 E-value: 8.67e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435803813 3 TETMKGSNYAWAIAIACVAFYAIPLGVVANQAGLFATPVMEEFGWSRTDATLYMTIQPWVAAICTPFAGKLISRFNPRWV 82
Cdd:COG2807 6 SSARRSRRAGRWLLLLAIVLVALNLRPAITSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERT 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435803813 83 MTAAAAVFGLASLACAWFTEPWQWNVYGVLYGASAAFwMYIATPTFINRWFAKSNGTVIGTIGVCASLIGAFMSPVIQGW 162
Cdd:COG2807 86 LLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGIAV-GNVLLPGLIKRWFPDRVGLMTGLYTAAMGLGAALAAGLTVPL 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435803813 163 ISGYGWHTARIIISVIALVASVVLTAALLRESPEkmgvlpwgygsaevaaaksdaksviEVSADEGVTAAQARKNPALWL 242
Cdd:COG2807 165 AAALGWRGALAVWALLALLALLLWLPLLRRRPAA-------------------------AAAAPAAASLRSLWRSPLAWL 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435803813 243 L-IIMAGFFVVAAGMMQQFSSYASTGALGAAVGALGVTVCMIGQLFGKFGLGWLCDHTGARiSGVVASIFGALGIAIVLF 321
Cdd:COG2807 220 LtLFFGLQSLLYYAVVAWLPPILRDAGLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDR-RPLLLLLGLLGLAGLLGL 298
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435803813 322 SVDSAMMFYVGVFLFGIGFAALNIVPPMACRQAFG-QKDYANIFSMVATGLNVFSGFSAIIYAQIFDITGSFAGCFWLII 400
Cdd:COG2807 299 LLAPGSLPWLWAVLLGLGQGGLFPLALTLIGLRARtPAEAAALSGMAQSVGYLLAALGPLLVGALHDATGSWTAALLLLA 378
|
410
....*....|...
gi 1435803813 401 GFYVVTLICSLVI 413
Cdd:COG2807 379 ALAVLMLVAGLLA 391
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
35-413 |
4.15e-24 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 103.07 E-value: 4.15e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435803813 35 GLFATPVMEEFGWSRTDATLYMTIQPWVAAICTPFAGKLISRFNPRWVMTAAAAVFGLASLACAWFTEPWQWN-VYGVLY 113
Cdd:cd17353 23 SVFNPPLSSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFGLGFILSAFAISLPLLFlGYGVLG 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435803813 114 GASAAFwMYIATPTFINRWFAKSNGTVIGTIGVCASLIGAFMSPVIQGWISGYGWHTARIIISVIALVaSVVLTAALLRE 193
Cdd:cd17353 103 GIGAGI-GYITPVSTAVKWFPDKRGLATGIVIAGFGLGSLIFSPLIAYLINTVGVPTTFLILGIIFLI-IIVIGAFLIRD 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435803813 194 SPEkmgvlpwGYGSAEVAAAKSDAKSVIEVsadegVTAAQARKNPALWLLIIMAgFFVVAAGMMqqFSSYAST-----GA 268
Cdd:cd17353 181 PPK-------GWVPPGVDPLANNAENSPRD-----YTPREMLRTPTFWLLWLMF-FLNATAGLM--LIGQAKPigqefAG 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435803813 269 LGAAVGALGVTVCMIGQLFGKFGLGWLCDHTGARISGVVASIFGALGIAIVLFSVDSAMMFYVGVFLFGIGFAALNIVPP 348
Cdd:cd17353 246 LDAGIAALAVSILSIFNGGGRPFWGWLSDKIGRKNTLSIAFLIQGVAMFLLPFIGSVAVLFVLGVALIGFCYGGGFALFP 325
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1435803813 349 MACRQAFGQKDYANIFSMVATGLNVfSGFSAIIYAQIFDITGSFAGCFWLIIGFYVVTLICSLVI 413
Cdd:cd17353 326 ALTADFFGTKNAGTNYGLLYTAKGV-GGLIGPIIAAYVLYTGGYNAAFIIAAALSLVALALALLL 389
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
5-415 |
2.01e-23 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 100.71 E-value: 2.01e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435803813 5 TMKGSNYAWAIAIACVAFYAIPLGVVANqAGLFATPVMEEFGWSRTDATLYMTIQPWVAAICTPFAGKLISRFNPRWVMT 84
Cdd:COG2271 1 ARAPSRYRWRILALLFLAYFLNYLDRSN-LSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435803813 85 AAAAVFGLASLACAWFTEPWQWNVYGVLYGASAAFwMYIATPTFINRWFAKSN-GTVIGTIGVCASLIGAFMSPVIQGWI 163
Cdd:COG2271 80 IGLLLWGLATLLFGFATSFWQLLLLRFLLGLGEAG-FFPAALKLIAEWFPPKErGRALGIFNAGGPLGGALAPPLLGWLL 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435803813 164 SGYGWHTARIIISVIALVASVVLTaallrespekmgvlpwgygsaevaaaksdaksvievsadegvtaaqarknpaLWLL 243
Cdd:COG2271 159 AAFGWRAAFLILGLPGLLLALLRF----------------------------------------------------WLLA 186
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435803813 244 IIMAGFFVVAAGMMQQFSSY-ASTGALGAAVGALGVTVCMIGQLFGKFGLGWLCDHTGARISGVVASIFGALGIAIVLFS 322
Cdd:COG2271 187 LAYFLVYFALYGFLTWLPTYlVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAALALLLLA 266
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435803813 323 -VDSAMMFYVGVFLFGIGFAALNIVPPMACRQAFGQKDYANIFSMVATGLNVFSGFSAIIYAQIFDITGsFAGCFWLIIG 401
Cdd:COG2271 267 lLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATG-YQAAFLLLAA 345
|
410
....*....|....
gi 1435803813 402 FYVVTLICSLVIVP 415
Cdd:COG2271 346 LALLAALLALLLLR 359
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
6-375 |
9.08e-17 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 81.17 E-value: 9.08e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435803813 6 MKGSNYAWAIAIACVAFYAIPLGVVANQAGLFATPVMEEFGWSRTDATLYMTIQPWVAAICTPFAGKLISRFNPRWVMTA 85
Cdd:COG2814 1 MPATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435803813 86 AAAVFGLASLACAWFTEPWQWNVYGVLYGASAAFwMYIATPTFINRWFAKSN-GTVIGTIGVCASLIGAFMSPVIQGWIS 164
Cdd:COG2814 81 GLLLFALGSLLCALAPSLWLLLAARFLQGLGAGA-LFPAALALIADLVPPERrGRALGLLGAGLGLGPALGPLLGGLLAD 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435803813 165 GYGWHTARIIISVIALVASVVLTAALLRESPEKmgvlpwgygsaevaaaksdaksvievSADEGVTAAQARKNPALWLLI 244
Cdd:COG2814 160 LFGWRWVFLVNAVLALLALLLLLRLLPESRPAA--------------------------RARLRGSLRELLRRPRLLLLL 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435803813 245 IMAGFFVVAAGMMQQFSSYASTGALGAAVGALGV--TVCMIGQLFGKFGLGWLCDHTGARISGVVASIFGALGIAIVLFs 322
Cdd:COG2814 214 LLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLllALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLAL- 292
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 1435803813 323 VDSAMMFYVGVFLFGIGFAALNIVPPMACRQAFGQKDYANIFSMVATGLNVFS 375
Cdd:COG2814 293 AGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGG 345
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
12-413 |
7.79e-16 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 78.36 E-value: 7.79e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435803813 12 AWAIAIACVAFYAIPLGVVaNQAGLFATPVMEEFGWSRTDATLYMTIQPWVAAICTPFAGKLISRFNPRWVMTAAAAVFG 91
Cdd:cd17352 1 GWVVVFASFLVNFFTDGIL-NSFGVLFVELLEEFGESTSDIAWIGSLLLGVSLFSGPLSSALVNRFGCRPVAIAGGLLAA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435803813 92 LASLACAWFTEPWQWNV-YGVLYGASAAFwMYIATPTFINRWFAKSNGTVIGtIGVCASLIGAFMSPVIQGW-ISGYGWH 169
Cdd:cd17352 80 LGLLLSSFATSLWQLYLtYGVLGGLGLGL-IYSPAIVIVGQYFEKKRGLATG-IAVAGSGVGTFVFPPLLRYlLDNYGWR 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435803813 170 TARIIISVIALVASVVltAALLRESPEKMGVlpwgygsaevaaaksdaksvievsadegvtaaqarkNPALWLLIIMAGF 249
Cdd:cd17352 158 GALLILGGLCLNLCVC--GLLLRLLKDPTFV------------------------------------LLALGVSFAMLGF 199
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435803813 250 FVvaagMMQQFSSYASTGALGAAVGALGVTVCMIGQLFGKFGLGWLCDHTGARISGVVASIFGALGIAIVLFSVDSAMMF 329
Cdd:cd17352 200 FV----PFVYLPSYAKSLGIDESDAAFLLSIIGISDIVGRILLGLLADKPRIGRLYLYIFTLLILGLSLLAFPLATTYVG 275
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435803813 330 YVGVF-LFGIGFAALNIVPPMACRQAFGQKDYANIFSMVATGLNVFSGFSAIIYAQIFDITGSFAGCFWLIIGFYVVTLI 408
Cdd:cd17352 276 LIVFSvLFGFCSGSYSSLTPVILADLVGLEKLSNAYGLVLLFQGLAALVGPPIAGLLRDYTGDYDAAFYFCGACLLLSGV 355
|
....*
gi 1435803813 409 CSLVI 413
Cdd:cd17352 356 LLFLL 360
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
34-379 |
1.42e-15 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 77.46 E-value: 1.42e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435803813 34 AGLFATPVMEEFGWSRTDATLYMTIQPWVAAICTPFAGKLISRFNPRWVMTAAAAVFGLASLACAWFTEPWQWNVYGVLY 113
Cdd:pfam07690 16 GPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLLVLRVLQ 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435803813 114 GASAAFwMYIATPTFINRWFAKSN-GTVIGTIGVCASLIGAFMSPVIQGWISGYGWHTARIIISVIALVASVVLtaALLR 192
Cdd:pfam07690 96 GLGAGA-LFPAALALIADWFPPEErGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVLL--LLPR 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435803813 193 ESPEKMGVLPWGYGSAEVAAAKSdaksvievsadegvtaaQARKNPALWLLIIMAGFFVVAAGMMQQFSSYASTGALGAA 272
Cdd:pfam07690 173 PPPESKRPKPAEEARLSLIVAWK-----------------ALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSAL 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435803813 273 VGALGVTVCMIGQLFGKFGLGWLCDHTGARISGVVASIFGALGIAIVLFSV--DSAMMFYVGVFLFGIGFAALNIVPPMA 350
Cdd:pfam07690 236 LAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSltLSSLWLLLALLLLGFGFGLVFPALNAL 315
|
330 340
....*....|....*....|....*....
gi 1435803813 351 CRQAFGQKDYANIFSMVATGLNVFSGFSA 379
Cdd:pfam07690 316 VSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
37-411 |
5.70e-15 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 75.93 E-value: 5.70e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435803813 37 FATPVMEEFGWSRTDATLYMTIQPWVAAICTPFAGKLISRFNPRWVMTAAAAVFGLASLACAWFTEPWQWNVYGVLYGAS 116
Cdd:cd06174 18 LLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFWLLLLGRFLLGLG 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435803813 117 AAFwMYIATPTFINRWFAKSNGTVIGTIGVCASLIGAFMSPVIQGWISGYGWHTARIIISVIALVASVVLTAALLRESPE 196
Cdd:cd06174 98 SGL-IDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWRAVFLIAAALALLAAILLLLVVPDP 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435803813 197 KmgvlpwgygsaevaaAKSDAKSVIEVSADEGVTAAQARKNPALWLLIIMAGFFVVAAGMMQQFSSY--ASTGALGAAVG 274
Cdd:cd06174 177 P---------------ESARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLflLDLGGLSVAVA 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435803813 275 ALGVTVCMIGQLFGKFGLGWLCDHTGARISGVVASIFGALGIAIVLFSVDSAMMFYVGVFLFGIGFAALNIVPPMACRQA 354
Cdd:cd06174 242 GLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAEL 321
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 1435803813 355 FGQKDYANIFSMVATGLNVFSGFSAIIYAQIFDITGSFAGCFWLIIGFYVVTLICSL 411
Cdd:cd06174 322 FPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAILLL 378
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
6-343 |
9.91e-15 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 75.28 E-value: 9.91e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435803813 6 MKGSNYAWAIAIACVAFYAIplGVVANQAGLFATPVMEEFGWSRTDATLYMTIQPWVAAICTPFAGKLISRFNPRWVMTA 85
Cdd:COG0738 1 MSKKNYRRALIAIYLLFFLW--GFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435803813 86 AAAVFGLASLACAWFTEPWQWNVYGVLYGASAAFWMyIATPTFINRWFAKSNGTVIGTIGVC---ASLIGAFMSPVIQGW 162
Cdd:COG0738 79 GLLLMALGLLLFALAPSYPLLLLALFLLGLGLGLLD-VAANPYVAALGPETAASRLNLLHAFfslGALLGPLLGGLLILL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435803813 163 ISGYGWHTARIIISVIALVASVVLTAALLRESPEKmgvlpwgygsaevaaaksdaksvIEVSADEGVTAAQARKNPALWL 242
Cdd:COG0738 158 GLSLSWHLPYLILAVLLLLLALLFLRSKLPEIEEE-----------------------EEEAAGSAASLKSLLKNPRLLL 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435803813 243 LIIMAGFFVVAAGMMQQFSSYASTGALG--AAVGALGVTVCMIGQLFGKFGLGWLCDHTGARISGVVASIFGALGIAIVL 320
Cdd:COG0738 215 GGLAIFLYVGAEGAIGDWLPLYLKDVLGlsEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLAL 294
|
330 340
....*....|....*....|...
gi 1435803813 321 FSvDSAMMFYVGVFLFGIGFAAL 343
Cdd:COG0738 295 LA-PGPWLALIGLALVGLGLSLM 316
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
42-344 |
2.28e-12 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 67.97 E-value: 2.28e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435803813 42 MEEFGWSRTDATLYMTIQPWVAAICTPFAGKLISRFNPRWVMTAAAAVFGLASLACAWFTEPWQWNVYGVLYGASAAFwM 121
Cdd:cd17477 23 LEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVWFLLRFVMGIGLAG-L 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435803813 122 YIATPTFINRWFAKSN-GTVIGTIGVCASLiGAFMSPVIQGWISGYGWHTarIIISVIALVASVVLTAALLRESPEKmgv 200
Cdd:cd17477 102 FVVSESWLNALATNENrGRVLGLYSTVLGL-GFALGPLLLALVGTAGALP--FLIAAVLLLLALVPLLLTRRAAPEI--- 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435803813 201 lpwgygsaeVAAAKSDAKSVIevsadegvtaaqaRKNPALWLLIIMAGFFVVAAGMMqqFSSYASTGALGAAVGALGVTV 280
Cdd:cd17477 176 ---------EEAESISLRRLL-------------RIAPLALLGAFVAGFLEGAFYSL--LPLYGLRLGLSVAQAALLLAA 231
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1435803813 281 CMIGQLFGKFGLGWLCDHTGARISGVVASIFGALGIAIVLFSVDSAMMFYVGVFLFGIGFAALN 344
Cdd:cd17477 232 FVLGGLLLQWPLGWLADRFDRRRVLLGCALLGALAALLLPLVPGLPLALLVLLFLWGGAAGPLY 295
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
38-413 |
3.81e-11 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 64.13 E-value: 3.81e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435803813 38 ATPVMEEFGWSRTDATLYMTIQPWVAAICTPFAGKLISRFNPRWVMTAAAAVFGLASLACAWFTEPWQWNVYGVLYGASA 117
Cdd:cd17319 26 APTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFLLGVAE 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435803813 118 AFwMYIATPTFINRWF-AKSNGTVIGTIGVCASLIGAFMSPVIQGWISGYGWHTARIIISVIALVAsVVLTAALLRespe 196
Cdd:cd17319 106 AG-FFPGAIKALAEWFpARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEGLLGLLL-AVLWWFYLR---- 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435803813 197 KMGVLPWGYGSAevaaaksdaksvievsadegvtaaqarkNPALWLLII-MAGFFVVAAGMmqqfsSYASTGALGAAVGA 275
Cdd:cd17319 180 QVWGLALGYFGI----------------------------NYALYGLLTwLPTYLKQARGF-----SLKQVGLLAAIPFL 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435803813 276 LGVTVCMIGqlfgkfglGWLCDHTGARISGVVASIFGALGIAIVLFS--VDSAMMFYVGVFLFGIGFAALNIVPPMACRQ 353
Cdd:cd17319 227 AGAIGMILG--------GRLSDRLLRGARRLVIIIGLLLAAVGLLLAylTTSPVVAVILLSLAGFGIGAASPVFWSLPAD 298
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435803813 354 AFGQKDYANIFSMVATGLNVFSGFSAIIYAQIFDITGSFAGCFWLIIGFYVVTLICSLVI 413
Cdd:cd17319 299 LLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDATGSYTAAFLFLAAVALLAALLVLLL 358
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
64-408 |
2.27e-10 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 61.82 E-value: 2.27e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435803813 64 AICTPFAGKLISRFNPRWVMTAAAAVFGLASLACAWFTEPWQWNVYGVLYGASAAFWMYIATPTFINRWFAKSNGTVIGT 143
Cdd:cd17325 45 LLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGI 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435803813 144 IGVcASLIGAFMSPVIQGWISGYGWHTARIIISVIALVASVVLTAALLRESPEKmgvlpwgygsaevaaaksdAKSVIEV 223
Cdd:cd17325 125 FSS-AIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLALLLLPEPRPP-------------------PNKRAVS 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435803813 224 SADEGVTAAQARKNPALWLLIIMAGFFVVAAGMMQQFSSYASTGALGAAVGALGV--TVCMIGQLFGKFGLGWLCDHTGA 301
Cdd:cd17325 185 AARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLlfGAQGLASALSQPPAGKLSDRIGR 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435803813 302 RISGVVASIFGALGIAIVLFsVDSAMMFYVGVFLFGIGFAALNIVPPMACRQAFGQKDYANIFSMVATGLNVFSGFSAII 381
Cdd:cd17325 265 KPLILIGLLLSAVALLLLPL-ATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLL 343
|
330 340
....*....|....*....|....*..
gi 1435803813 382 YAQIFDiTGSFAGCFWLIIGFYVVTLI 408
Cdd:cd17325 344 GGFLYD-AFGFATPFLAAAALLLLAAV 369
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
21-349 |
7.47e-10 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 60.69 E-value: 7.47e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435803813 21 AFYAIPLGVVANQAGLFATPVM-EEFGWSRTDATLYMTIQPWVAAICTPFAGKLISRFNPRW-----VMTAAAAVFGLAS 94
Cdd:COG2211 16 GLGDLGLNLAFGLLSAYLLYFYtDVLGLSAALVGLILLVARLWDAITDPLIGALSDRTRTRWgrrrpWILIGAIPLALSF 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435803813 95 LACAWFTEPWQWNVYGVLYGASAAF-------------WMYIATPTFINRwfaKSNGTVIGTIGVCASLIGAFMSPVIQG 161
Cdd:COG2211 96 VLLFTAPDLSPTGKLIYALVTYLLLglaytlvnipysaLGAELTPDYEER---TRLSSWRFAFAGLGGLLASVLPPPLVA 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435803813 162 WISG---YGWHTARIIISVIALVAsVVLTAALLRESPEkmgvlpwgygsaeVAAAKSDAKSVIevsadegvtaAQARKNP 238
Cdd:COG2211 173 AFGGdaaLGYRLTALIFAVLGLLA-FLLTFFGTKERPV-------------PEEEKVSLKESL----------KALLKNR 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435803813 239 ALWLLIIMAGFFVVAAGMMQQFSSYASTGALGAAVGALGV--TVCMIGQLFGKFGLGWLCDHTGARISGVVASIFGALG- 315
Cdd:COG2211 229 PFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLllALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGl 308
|
330 340 350
....*....|....*....|....*....|....
gi 1435803813 316 IAIVLFSVDSAMMFYVGVFLFGIGFAALNIVPPM 349
Cdd:COG2211 309 LLLFFLGPGNLWLLLVLAALAGIGLGAILVLPWA 342
|
|
| MFS_MCT_like |
cd17314 |
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ... |
35-392 |
3.90e-09 |
|
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340872 [Multi-domain] Cd Length: 385 Bit Score: 58.19 E-value: 3.90e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435803813 35 GLFATPVMEEFGWSRTDATLYMTIQPWVAAICTPFAGKLISRFNPRWVMTAAAAVF--GLASLACAWFTEPWqWNVYGVL 112
Cdd:cd17314 23 SLFYQPWQDAFGYSSSQIATAASLSNLGMLLTQPILGFIADSFGPRPLMALAGIMVlaGYTYLSYVFNSFPL-SYACFVF 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435803813 113 YGASAAFwMYIATPTFINRWFAKSNGTVIGTIGVCASLIGAFMSPVIQGWISGYGWHTARIIISVIALVASVVLTAALLR 192
Cdd:cd17314 102 IGAGTGI-LYGSAVLVTTQYFPDTKGLALGLPTTGYSLGLVLGSPLLRILWVFYGLALVYTILGILAAIVLSVVSLLGFK 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435803813 193 ESPekmgvlpwgygsaevaaaksDAKSVIEVSADEGVTAAQARKNPALWLL-IIMAGFFVVAAGMMQQFSSYASTGALGA 271
Cdd:cd17314 181 EPP--------------------DNQARLHVQKKKTQTMGEIFRDKVFWILfIAIFLVLIGGFLFIANMASLVRSLQLDA 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435803813 272 A-VGALGVTVCMIGQLFGKFGLGWLCDHTGARISGVVAS-IFGALGIAIVLFSVDSAMMFYVGVF-LFGIGFAALNIVPP 348
Cdd:cd17314 241 PsFVTKLMSIYGLFNAFGRLLWGIVADFFGGRLSTLSILlTILGLGLCAFLFLLKMTPVGLVLTGsLLGFSYGGLFTVYP 320
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 1435803813 349 MACRQAFGQKDYANIFSMVATGLNVFSGFSAIIYAQIFDITGSF 392
Cdd:cd17314 321 ATVSTVFGTESFATLYGILLFAPAIGSILGPMLGAKFYDRTPSY 364
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
37-368 |
1.41e-08 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 56.23 E-value: 1.41e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435803813 37 FATPVM-EEFGWSRTDATLYMTIQPWVAAICTPFAGKLISRFNPRWVMTAAAAVFGLASLACAWFTEPWQWNVYGVLYGA 115
Cdd:TIGR00881 16 LAMPYLvEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLWVMAALWALNGI 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435803813 116 SAAFWMYIATPTfINRWFAKSN-GTVIGTIGVCASLIGAFMSPVIQGWIS-GYGWHTARIIISVIALVASVVLTaALLRE 193
Cdd:TIGR00881 96 FQGMGWPPCGRT-VTKWFSRSErGTWVSFWNCSHNVGGGLLPPLVLFGIAeLYSWHWVFIVPGIIAIIVSLICF-LLLRD 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435803813 194 SPEKmgvlpwgYGSAEVAAAKSDAKSVIEVSADEGVTAAQAR-----KNPALWLLIIMAGF-FVVAAGMMQQFSSYAS-T 266
Cdd:TIGR00881 174 SPQS-------CGLPPAEEMPNEEPDGDAEKKEEELTKKQIFlqyvlLNKVLWYISLGYVFvYVVRTGILDWSPLYLTqE 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435803813 267 GALGAAVGALGVTVCMIGQLFGKFGLGWLCDHTGARISGVVASIFGALGIAIVLFS---------VDSAMMFYVGVFLFG 337
Cdd:TIGR00881 247 KGFSKEKASWAFTLYELGGLVGTLLAGWLSDKLFNGRRGPLAVFFMALIIVSLLVYwlnpaanplMDLICLFALGFLVYG 326
|
330 340 350
....*....|....*....|....*....|....*.
gi 1435803813 338 ----IGFAALNIVPPMACRQAFGQKDY-ANIFSMVA 368
Cdd:TIGR00881 327 pqmlIGVIASELAPKKAAGTAAGFVGFfAYLGGILA 362
|
|
| PRK08633 |
PRK08633 |
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated |
63-414 |
7.70e-08 |
|
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated
Pssm-ID: 236315 [Multi-domain] Cd Length: 1146 Bit Score: 54.93 E-value: 7.70e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435803813 63 AAICTPF------AGKLISRFNPRWVMTAAAAV-FGLASLACAWFTEPWQWNVYGV--LYGASAAFWM---YIATPTFIN 130
Cdd:PRK08633 54 ALFLLPFlllsspAGFLADKFSKNRVIRIVKLFeVGLTLLIVLAYYLGWFWLAFAVtfLLGAQSAIYSpakYGIIPELVG 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435803813 131 RWF-AKSNGtVIGTIGVCASLIGAFMSPVI-QGWISgygwHTARIIISVIALVASVVLTAALLREspekmgVLPWGYGSA 208
Cdd:PRK08633 134 KENlSRANG-LLEAFTIVAILAGTALFSFLfESVNG----NTPSEILGRIAPAGLVLLAVAVLGL------IFAYRLPKV 202
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435803813 209 EVAAAKSDAKSVIEVSADEGVTAAQARKNPALWLLIIMAGFF-VVAAGMMQQFSSYA-------STGALGAAVGALGVTV 280
Cdd:PRK08633 203 PAAAPEVFDKKKYLFPKLLWRNLKLLRSDRVLWLAIIGLSYFwFISQLAQANFPAYAkevlgldNTFQVQYLLAASAIGI 282
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435803813 281 CMIGQLFGKFglgwlcdhTGARIS-GVVAsiFGALGIAIVLF---SVDSAMMFYVGVFLFGIgFAALNIVPPMACRQAFG 356
Cdd:PRK08633 283 GIGSLLAGRL--------SGRHIElGLVP--LGALGLALSLFllpTAPSLASVLVLFFLFGF-SAGLFIVPLNALIQFRA 351
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1435803813 357 QKDY-------ANIFSMVATGLnvFSGFSAII-YAQIfditgSFAGCFWLIIgfyVVTLICSLVIV 414
Cdd:PRK08633 352 PEKElgkvlaaNNFLQNVGMLL--FLALTTLFsGLGL-----SPAGLFYLIA---LVTLIGTLYTL 407
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
4-338 |
1.34e-07 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 53.13 E-value: 1.34e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435803813 4 ETMKGSNYAWAIAIACVAFYAIPlGVVANQAGLFATPVMEEFGWSRTDATLYMTIQPWVAAICTPFAGKLISRFNPRWVM 83
Cdd:TIGR00895 7 RKQPLSRYQWRAIILSFLIMLMD-GYDLAAMGFAAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435803813 84 TAAAAVFGLASLACAWFTEPWQWNVYGVLYGASAAFWMYIATPTFINRWFAKSNGTVIGTIGvCASLIGAFMSPVIQGW- 162
Cdd:TIGR00895 86 LWSILLFSVFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMF-CGYPIGAAVGGFLAGWl 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435803813 163 ISGYGWHTARIIISVIALVASVVLTAAL--------------LRESPEKMGVLPWGYGSAEVAAAKSDAKsVIEVSADEG 228
Cdd:TIGR00895 165 IPVFGWRSLFYVGGIAPLLLLLLLMRFLpesidflvskrpetVRRIVNAIAPQMQAEAQSALPEQKSTQG-TKRSVFKAL 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435803813 229 VTAAQARKNPALWLLIIMAGFFVVAAGMMQQFSSYASTGALGAAVGALGVTVCmiGQLFGKFGLGWLCDHTGARISGVVA 308
Cdd:TIGR00895 244 FQGKTARITVLLWLLYFMLLVGVYFLTNWLPKLMVELGFSLSLAATGGALFNF--GGVIGSIIFGWLADRLGPRVTALLL 321
|
330 340 350
....*....|....*....|....*....|
gi 1435803813 309 sIFGALGIAIVLFSVDSAMMFYVGVFLFGI 338
Cdd:TIGR00895 322 -LLGAVFAVLVGSTLFSPTLLLLLGAIAGF 350
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
43-411 |
2.16e-07 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 52.55 E-value: 2.16e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435803813 43 EEFGWSRTDATLYMTIQPWVAAICTPFAGKLISRFNPRWVMTAAAAVFGLASLACAWFTEPWQWNVYGVLYGASAAFWMY 122
Cdd:cd17324 27 RDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHGGFWA 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435803813 123 IATPTFINRWFAKSNGTVIGTIgVCASLIGAFMSPVIQGWISGY-GWHTARIIISVIALVASVVLTAALLRESPEKMGVL 201
Cdd:cd17324 107 IAAAYAADLVPPEKRGRAIGLV-FSGLTLGLVLGRPLGGLLGQLlGWRAAFLAIAVLALLAALLLWRLLPSLPPKKPGSL 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435803813 202 PWGYGSAEVaaaksdaksvievsadegvtaaqaRKNPALWLLIIMAGFFVVAAGMMQQFSSY---ASTGALGAAVGALgV 278
Cdd:cd17324 186 GLLSSLLLL------------------------LRNPRLRLAYLITFLLFGGFFALYTYLAPfltDVPGFSSSAIIGL-L 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435803813 279 TVCMIGQLFGKFGLGWLCDHTGARISGVVASIFGALGIAIVLFSVDSAMMFyVGVFLFGIGFAALNiVPPMACRQAFGQK 358
Cdd:cd17324 241 LLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLGPSPLLLL-VGLVLWGLGFFAAH-SALQTRVLRLAPE 318
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 1435803813 359 DYANIFSMVATGLNVFSGFSAIIYAQIFDITGsFAGCFWLIIGFYVVTLICSL 411
Cdd:cd17324 319 ARGLASSLYLAAYNLGGALGAALGGLVLDHGG-WAGVGWVGAALLLLALLLAL 370
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
45-340 |
6.13e-07 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 51.03 E-value: 6.13e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435803813 45 FGWSRTDATLYMTIQPWVAAICTPFAGKLISRFNPRWVMTAAAAVFGLASLACAWFTEPWQWNVYGVLYGASAAFWMYIA 124
Cdd:cd17473 30 VPNSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLGIGVAGIMTLA 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435803813 125 TpTFINRWF-AKSNGTVIGTIGVCASLIGAFmSPVIQGWISGYGWHTARIIISVIALVAsvVLTAALLRESPEKmgvlpw 203
Cdd:cd17473 110 T-ALIGDYFeGEERAKMLGLQSAAMSLGGVV-FLLLGGALAEIGWRAPFLVYLLALPVL--ILVLLFLPEPARK------ 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435803813 204 gygsaevaaaksdaksviEVSADEGVTAAQARKNPALWLLIIMAGFFVVAA--GMMQQFSSY-ASTGALGAAVGALGVTV 280
Cdd:cd17473 180 ------------------SKSAASPGAATAAALPWKRVLPIYFLAFLAMLLfyVIPIQLPFLlQERGGGSAALIGLALAI 241
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435803813 281 CMIGQLFGKFGLGWLCDHTGARISGVVASIFGALGIAIVLFSvDSAMMFYVGVFLFGIGF 340
Cdd:cd17473 242 ASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLLALA-SGLWVVLLGAILAGLGF 300
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
48-346 |
1.24e-06 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 50.31 E-value: 1.24e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435803813 48 SRTDATLYMTIQPWVAAICTPFAGKLISRFNPRWVMTA-----AAAVFGLASLACAWFTEPWQWNVYGVLYGASAAFWM- 121
Cdd:cd06173 32 SALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILadllrALLAAVLALLALLGSLSLWLLLVLAFLLGIASAFFGp 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435803813 122 --YIATPTFINRWFAKSNGTVIGTIGVCASLIGafmsPVIQGWISGYGWHTARIIISVIALVASVVLTAALLRESPEKMG 199
Cdd:cd06173 112 arQALLPELVPKEQLVRANALNSLATQLARIIG----PALGGLLVALLGPGGAFAINALSFLLSALLLLFIRRPPPAAPG 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435803813 200 vlpwgygsaevaaaksdAKSVIEVSADEGVTAAQARKNPALWLLIIMAGFFVVAAGMMQQFSSYAS-TGALGAAVGALGV 278
Cdd:cd06173 188 -----------------ESSSLLLRDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKeVLGGGAAGYGLLL 250
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1435803813 279 TVCMIGQLFGKFGLGWLCDHTGARISGVVASIFGALGIAIVLFSVdSAMMFYVGVFLFGIGFAALNIV 346
Cdd:cd06173 251 AAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSP-SLWLLLAALFLLGLAGGLFNVP 317
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
41-344 |
1.33e-06 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 50.26 E-value: 1.33e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435803813 41 VMEEFGWSRTDATLYMTIQPWVAAICTPFAGKLISRFNPRWVMTAAAAVFGLASLACAwFTEPWQWNVYG-VLYGASAAF 119
Cdd:cd17474 25 IAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCG-LSDSFALLLAGrALQGIGAAG 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435803813 120 WMYIATPTFINRWFAKSNGTVIGTIGVcASLIGAFMSPVIQGWISGYGWHTARIIISVIALVAsVVLTAALLRESPEKMG 199
Cdd:cd17474 104 LGPLALTLIGDLFEGGERAKAMGLYEA-ALGLGIAVGPLLGGLLAAISWRYPFFLLAALIPVA-FLAILFLLPEPKEKAK 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435803813 200 VLPWGYGSAEVAAAKSDAKSVIEVSAdegvtaaqarknpalwlLIIMAGFFVVAAGM--MQQFSSYASTGALGAAVGALG 277
Cdd:cd17474 182 SSSATKLRDLKKALRGRGLLTFLVSA-----------------FLYFFLYFAFLTYLpfLLELLYGISPIIIGLLFAGWS 244
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1435803813 278 VTVCmigqlFGKFGLGWLCDHTGARISGVVASIFGALGIAIVLFSVDSAMMFYVGVFLFGIGFAALN 344
Cdd:cd17474 245 VLLA-----LGSLFVGRLLKKRFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNL 306
|
|
| MFS_MosC_like |
cd17393 |
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of ... |
63-347 |
2.72e-06 |
|
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters; The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340951 [Multi-domain] Cd Length: 373 Bit Score: 49.18 E-value: 2.72e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435803813 63 AAICTPFAGKLISRFNPRWVMTAAAAVFGLASLACAWFTEPWQWNVYGVLYGASAAfWMYIATPTFINRWFAKSNGTVIG 142
Cdd:cd17393 47 ALVAMPLAGRLVARFGSRRVTRLGALLLLLALLLLGLAPSVPALALALFLFGAANG-ALDVAMNAQGVAVERAYGRPIMS 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435803813 143 TIGVCASL---IGAFMSPVIQGWISGYGWHTarIIISVIALVASVVLTAALLRESPEKMgvlpwgygsaevaaaksdaks 219
Cdd:cd17393 126 SLHAMWSLgglAGALLGAAAIGAGVSPGVHL--LAAAVLLLLAALVAIRALLPGTGEAA--------------------- 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435803813 220 viEVSADEGVTAAQARKNPALWLLIIMAGFFVVAAGMMQQFSSYASTGALG--AAVGALGVTVCMIGQLFGKFGLGWLCD 297
Cdd:cd17393 183 --EDRPDGAGKPGFLLPNRLLLLLGLLALAAALAEGAAADWSALYLRDVLGasAALAALGYAVFSLAMTVGRLFGDRLVD 260
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 1435803813 298 HTGARISGVVASIFGALGIAIVLFSvDSAMMFYVGVFLFGIGFAalNIVP 347
Cdd:cd17393 261 RFGDVAVLRAGALLAALGLLLALLA-PSVWVALAGFALMGLGLS--VVVP 307
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
42-192 |
4.93e-06 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 48.34 E-value: 4.93e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435803813 42 MEEFGWSRTDATLYMTIQPWVAAICTPFAGKLISRFNPRWVMTAAAAVFGLASLACAWFTEPWQWNVYGVLYGASAAFWM 121
Cdd:cd17503 23 MGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIFRILQGFGGGVLI 102
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1435803813 122 YIATPTFINRWFAKSNGTVIGTIGVCAsLIGAFMSPVIQGWIS-GYGWHTARIIISVIALVAsvVLTAALLR 192
Cdd:cd17503 103 PLAQTILLRIYPPEKRGAAMGLVGLVI-LLAPAIGPTLGGWLTdNLSWRWIFYINLPIGILA--LLLAPLLD 171
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
43-343 |
7.40e-06 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 47.62 E-value: 7.40e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435803813 43 EEFGWSRTDATLYMTIQPWVAAICTPFAGKLISRFNPRWVMTAAAAVFGLASLACAWFTEPWQWNVYGVLYGASAAFwMY 122
Cdd:cd17475 24 EDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLFLVGAGYGS-VQ 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435803813 123 IATPTFINRWFAKSN-GTVIGTIGVCASLIGAFMSPVIQGWISGYGWHTArIIISVIALVASVVLTAALLRESPEkmgvl 201
Cdd:cd17475 103 PGGGRAIMRWFPPRErGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAA-FVVAGLVSILAAVLFWLFYREPPA----- 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435803813 202 pwgygsaevaaaksdAKSVIEVSADEGVTAAQARKNPALWLLIIMAGFFVVAAGMMQQFSSYASTGALGAAVGALGV--T 279
Cdd:cd17475 177 ---------------ASAATESASTLLRSLKEVLRNRDVWLIAIAGALLVAPQFALLTFLLLFLHDHLGLSVVAAGAllA 241
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1435803813 280 VCMIGQLFGKFGLGWLCDHTGA---RISGVVASIFGALGIAIVLFSVDSAMMFYVGVFLFGIGFAAL 343
Cdd:cd17475 242 VAQLGGALGRIGLGRVSDRVFGgrrRPVLVITAAIAAAALLVLSLLSPGTPLWLLVLLLILLGLFAI 308
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
3-186 |
1.10e-05 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 47.19 E-value: 1.10e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435803813 3 TETMKGSNYAWAIAIACVAFYAIPLGVVANQAgLFATPVMEEFGWSRTDATLYMTIQPWVAAICTPFAGKLISRFNPRWV 82
Cdd:cd17325 189 RSGLRLLLRDRRLLALFLAIFVLAFAFGALEP-FLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPL 267
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435803813 83 MTAAAAVFGLASLACAWFTEPWQWNVYGVLYGASAAFWMYIATPTFINRWFAKSNGTVIGTIGVCASlIGAFMSPVIQGW 162
Cdd:cd17325 268 ILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFS-LGMVLGPLLGGF 346
|
170 180
....*....|....*....|....*
gi 1435803813 163 ISG-YGWHTARIIISVIALVASVVL 186
Cdd:cd17325 347 LYDaFGFATPFLAAAALLLLAAVLF 371
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
43-408 |
1.93e-05 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 46.48 E-value: 1.93e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435803813 43 EEFGWSRTDATLYMTIQPWVAAICTPFAGKLISRFNPRWVMTAAAAVFGLASLACAWFTEP-WQWNVYGVLYGASAAfwM 121
Cdd:cd17341 27 DDLGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRRVFIASLLLLLIPLLALALAVSSyWGLLVLGFLLGFAGA--N 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435803813 122 YIATPTFINRWFAKS-NGTVIGTI---GVCASLIGAFMSPVIQGWIS----GYGWHTArIIISVIALVASVVLTAALLRE 193
Cdd:cd17341 105 FASGQPWASFWFPKEkIGGAAGGIagaGNMGVAVSQLLAPLIAGAIVfdggFVGWRNA-FFVPGILLAIAAVLVLLFGDD 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435803813 194 SPEkmgvlpwgyGSAEVAAAKSDAKSVIevsadegvtaaqarKNPALWLL-IIMAGFFVVAAGMMQQFSSYASTG----- 267
Cdd:cd17341 184 LPT---------GKASALEFLKVQLAVL--------------KNYRTWILsLLYGVTFGSFVGFSNVLPTYFKTRfglpl 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435803813 268 ALGAAVGALGVTVCMIGQLFGkfglGWLCDHTGAR----ISGVVASIFGALGIAIVLFSVDSAMMFYVGVFLF----GIG 339
Cdd:cd17341 241 VTAGILAALFPLAGALARPAG----GWLSDRFGGRrrlwWLFIVMTIGAALLSLSLPTSGTNLVLFLALFVALglgaGAG 316
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1435803813 340 FAALNIVPPMACRQAFGQkdyanIFSMVATGLNVFSGFSAIIYAQIFDITGSFAGCFWLIIGFYVVTLI 408
Cdd:cd17341 317 NGSVFRMVPFIFRRELGA-----VTGLVGAIGGLGGFFLPLLFGSSALMTGSGVGAFSLFGVLAVACTL 380
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
44-343 |
2.65e-05 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 46.05 E-value: 2.65e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435803813 44 EFGWSRTDATLYMTIQPWVAAICTPFAGKLISRFNPRWVMTAAAAVFGLASLACAWFTEPWQWNVYGVLYGASAAFWMYI 123
Cdd:cd17489 25 DLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIGWGAFTTA 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435803813 124 ATPTFINRWFAKSNGTVIGTIGVCASlIGAFMSPVIQGWISGYGWHTARIIISVIALVASVVLtaallrespekmgvlpw 203
Cdd:cd17489 105 AATLVADIIPPSRRGEGIGYYGLATT-LAMALGPALGLFLYQHLGFAVLFIVAAVLALLALLL----------------- 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435803813 204 gygsaevAAAKSDAKSVIEVSADEGVTAAQARKNPALWLLIIMAGFFVVAAGMMQQF-SSYAStgALGAAVGALGVTVCM 282
Cdd:cd17489 167 -------VFLVKDPPPVAAEEAEAGTRAFRRLVEKKVLPPALILFLASIAYGAISTFlPLYAA--ERGISNAGLFFTVYA 237
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1435803813 283 IGQLFGKFGLGWLCDHTGARISGVVASIFGALGIAIVLFSvDSAMMFYVGVFLFGIGFAAL 343
Cdd:cd17489 238 IALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFA-GSPWMLLLAAVLYGLGFGLL 297
|
|
| BtlA |
COG2270 |
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ... |
56-422 |
2.91e-05 |
|
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];
Pssm-ID: 441871 [Multi-domain] Cd Length: 424 Bit Score: 45.91 E-value: 2.91e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435803813 56 MTIQPWVAAICTPFAGKLISRFNPRWVMTAAAAVFGLASLACAWFTEPWQWNVYGVLYGASAAFWMY-----------IA 124
Cdd:COG2270 58 LAIAGLLVALLAPVLGAIADRSGRKKPFLAFFTLLGVLATAALFFVAPGGLWLGLLLFVLANIGFEGslvfynaflpdIA 137
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435803813 125 TPTFINRWFAKsnGTVIGTIGVCASLI---GAFMSPVIQGWISGYgwHTARIIISVIAL--VASVVLTAALLRESPekmg 199
Cdd:COG2270 138 TPEEIGRVSGL--GWALGYLGGVLLLLinlALFLKPEAFGLPDAG--EAVRISFLLTALwwLLFALPLFLFLPERP---- 209
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435803813 200 vlpwgygsaeVAAAKSDAKSVIEVSADEGVTAAQARKNPALWLLIImaGFFVVAAGM--MQQFSSYASTGALGAAVGALG 277
Cdd:COG2270 210 ----------RPGPAPPRGAVRAGFRELRRTLRELRRYRDLLRFLL--AYFFYRDGVqtVIAFAGIYAAGVLGFSTTELI 277
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435803813 278 VTVcMIGQL---FGKFGLGWLCDHTGARISgVVASIFGALGIAIVLFSVDSAMMFYVGVFLFGIGFAALN---------I 345
Cdd:COG2270 278 VFG-LLVQIvaaLGALLFGRLDDRIGPKRV-ILVSLVIWIVVCLAAYFLTTALAFWILGLLIGLVMGGIQalsrsllarL 355
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1435803813 346 VPPmacrqafgqKDYANIFSMVATGLNVFSGFSAIIYAQIFDITGSFAGCFWLIIGFYVVTLI-CSLVIVPMGRRSWA 422
Cdd:COG2270 356 IPP---------GREAEFFGLYALSGKAASFLGPLLFGLVTQLTGSQRLGILSLIVFFVIGLVlLLRVKVPRGRAAAG 424
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
3-295 |
3.04e-05 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 45.57 E-value: 3.04e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435803813 3 TETMKGSNYAWAIAIACVAFYAIPLGVVAnqAGLFATPVMEEFGWSRTDATLYMTIQPWVAAICTPFAGKLISRFNPRWV 82
Cdd:COG0477 4 TDAAPTRRRRRALLALALGTFLEGLDFTI--VNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435803813 83 MTAAAAVFGLASLACAWFTEPWQWNVYGVLYGASAAFwMYIATPTFINRWFAKSNGTVIGTIGVCASLIGAFMSPVIQGW 162
Cdd:COG0477 82 LLIGLLLFGLASLLCGLAPSPELLIAARALQGIGAGG-LMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435803813 163 ISGY-GWHTARIIISVIALVAsvVLTAALLRESPEKMGVLPWGYGSAEVAAAKSDAKSVIEVSADEGVTAAQARKNPALW 241
Cdd:COG0477 161 LVAAlGWRWIFLINAPLGLLA--LVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAA 238
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 1435803813 242 LLIIMAGFFVVAAGMMQQFSSYASTGALGAAVGALGVTVCMIGQLFGKFGLGWL 295
Cdd:COG0477 239 LLLLLALLLLALLLLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLA 292
|
|
| MFS_SLC37A4 |
cd17343 |
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute ... |
37-243 |
4.71e-05 |
|
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 4 (SLC37A4), one of four SLC37 family proteins in vertebrates, is better known as glucose-6-phosphate transporter (G6PT). It is also called sugar phosphate exchanger 4 (SPX4), G6P translocase, or transformation-related gene 19 protein (TRG-19). G6PT is a phosphate (Pi)-linked G6P antiporter, catalyzing G6P:Pi and Pi:Pi exchanges. Deficiencies in human G6PT lead to glycogen storage disease type Ib (GSD-Ib), which is a metabolic and immune disorder. G6PT is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340901 [Multi-domain] Cd Length: 409 Bit Score: 45.40 E-value: 4.71e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435803813 37 FATP-VMEEFGWSRTDATLYMTIQPWVAAICTPFAGKLISRFNPRWVMTAAAAVFGLASLACAWFTEPWQ----WNVYGV 111
Cdd:cd17343 24 FVLPsLMNELGLDKSDLGLITSSQSLAYAISKFIGGVLSDQISARWLFSSGLVLSGLTTVAFSGSSSVWVfsilWFLNGL 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435803813 112 LYGASaafWMYIAtpTFINRWFAKSN-GTVIGTIGVCASLIGAfMSPVIQGWIS-GYGWHTARIIISVIALVASVVLtAA 189
Cdd:cd17343 104 AQGLG---WPPCA--KILRKWFSPSQfGTWWSVLSTSMNLAGS-LGPILATLLAlSYGWRSTLSISGTVAVVMSVVC-LL 176
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 1435803813 190 LLRESPEKMGVlpwgyGSAEVAAAKSDAKSvieVSADEGvTAAQARKNPALWLL 243
Cdd:cd17343 177 FIKNEPSDVGL-----NNIEEEESKGKKKK---SPRGES-TLKELLLSPFLWLL 221
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
40-195 |
1.62e-04 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 43.42 E-value: 1.62e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435803813 40 PVMEEFGWSRTDATLYMTIQPWVAAICTPFAGKLISRFNPRWVMTAAAAVFGLASLACAWFTEPWQwnvYGVLYGASAAF 119
Cdd:cd17312 28 PIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANIFMGFSTSLWF---FAVLWGLNGLF 104
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1435803813 120 WMYIATP--TFINRWFA-KSNGTVIGTIGVCASLIGAFMSPVIQGWISGYGWHTARIIISVIALVASVVLTaALLRESP 195
Cdd:cd17312 105 QSMGWPPcvKLLGNWFSkKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRAAFLVPGIVGLVVAIILF-FFLRDSP 182
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
38-389 |
2.57e-04 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 42.99 E-value: 2.57e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435803813 38 ATPVMEEFGWSRTDATLYMTIQPWVAAICTPFAGKLISRFNPRWVMTAAAAVFGLASLACAWFTEPWQWNVYGVLYGASA 117
Cdd:cd17328 22 LPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQLLLFRALVGIGE 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435803813 118 AFWMYIAtPTFINRWFAKSNGTVIGTIGVCASLIGAFMSPVIQGWI--SGYGWHTArIIISVIALVASVVLTAALLRESP 195
Cdd:cd17328 102 ASYSPIA-PTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVaqATGGWRWA-FRVTGVLGVLLAILLLLFVREPP 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435803813 196 EKmgvlpwgyGSAEVAAAKSDAKSVIEVsadegvtAAQARKNPALWllIIMAGFFVVAagmmqqfssyASTGALGAAVGA 275
Cdd:cd17328 180 RG--------AAEGGVMAKSTATSFLAD-------LKALAKNPSFI--LSTLGFTAVS----------FVTGALAFWAPT 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435803813 276 LgvtvcmigqLFGKFGLGWLCDHTGARISGVVASIFGALGIAIVLFSVDSAMMFYVGVFLFGIGFAALNIVPPMACRQAF 355
Cdd:cd17328 233 F---------FLRAFGVGDLSSADVGLIFGAITCIAGVLGVLLGGILADRLRRKTPRADPLVCAVGLLAAAPFLFLALVL 303
|
330 340 350
....*....|....*....|....*....|....
gi 1435803813 356 GQKDYANIFSMVATGlnvfSGFSAIIYAQIFDIT 389
Cdd:cd17328 304 ALSNLLLAWVLLFLG----EFLLSLNWAPVFAIL 333
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
230-415 |
3.94e-04 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 42.27 E-value: 3.94e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435803813 230 TAAQARKNPALWLLIIMAGFFVVAAGMMQQF-SSYASTGALGAAVGALGVTVCMIGQLFGKFGLGWLCDHTGARISGVVA 308
Cdd:COG2814 2 PATPRRRWLALLALALGAFLSGLGIGIVLPAlPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435803813 309 SIFGALGIAIVLFSvDSAMMFYVGVFLFGIGFAALNIVPPMACRQAFGQKDYANIFSMVATGLNVFSGFSAIIYAQIFDI 388
Cdd:COG2814 82 LLLFALGSLLCALA-PSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADL 160
|
170 180
....*....|....*....|....*..
gi 1435803813 389 TGsFAGCFWLIIGFYVVTLICSLVIVP 415
Cdd:COG2814 161 FG-WRWVFLVNAVLALLALLLLLRLLP 186
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
129-350 |
8.81e-04 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 41.46 E-value: 8.81e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435803813 129 INRWFAKSNGTVIGTIGVCASLIGAFMSPVIQGWISGYG----WHTARIIISVIALVASVvLTAALLRESPEKMGVLPWG 204
Cdd:cd17345 120 MVHWFSKKERGTWTSIWNISHNVGGGLVGPLAGLGLAIFgdgwWRGAFIFPAIIAIIVAV-IVLFLGKDTPESEGLPPIE 198
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435803813 205 YGSAEVAAAKSDAKSVIEVSADEgVTAAQARKNPALWLLIIMAGF-FVVAAGMMQQFSSYASTGA-LGAAVGALGVTVCM 282
Cdd:cd17345 199 EYKGDYPEEADGEEEEQELSAWE-IFVKYVLKNKLLWYIAIANVFvYLVRYGILDWAPTYLSEVKgFSKAQAMWAFSLFE 277
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1435803813 283 IGQLFGKFGLGWLCDHTGARISGVVASIFGALGIAIVLF-------SVDSAMMFYVGVFLFG----IGFAALNIVPPMA 350
Cdd:cd17345 278 WAAIPGTLLAGWLSDKLFKGRRAPTGIIFMILVIVALIVywlapnvLVDLIALIALGFLIYGpvmlIGLQALELVPKKA 356
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
242-415 |
1.17e-03 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 40.87 E-value: 1.17e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435803813 242 LLIIMAGFFVVAAGMMQQFSSYASTGALGAAVGALGVTVCMIGQLFGKFGLGWLCDHTGARISGVVASIFGALGIAIVLF 321
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435803813 322 SVDSAMMFyVGVFLFGIGFAALNIVPPMACRQAFGQKDYANIFSMVATGLNVFSGFSAIIYAQIFD-ITGSFAGCFWLII 400
Cdd:cd06174 81 APSFWLLL-LGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASsLGFGWRAVFLIAA 159
|
170
....*....|....*
gi 1435803813 401 GFYVVTLICSLVIVP 415
Cdd:cd06174 160 ALALLAAILLLLVVP 174
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
41-191 |
1.30e-03 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 40.62 E-value: 1.30e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435803813 41 VMEEFGWSRTDATLYMTIQPWVAAICTPFAGKLISRFNPRWVMTAAAAVFGLASLACAWFTEPWQWNVYGVLYGASAAFW 120
Cdd:cd17321 22 IARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFLIAARALQGIGAAAI 101
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1435803813 121 MyIATPTFINRWFAKSN-GTVIGTIGVcASLIGAFMSPVIQGWISGY-GWHTA---RIIISVIALVASVVLTAALL 191
Cdd:cd17321 102 M-PASLALIAATFPGERrGRALGLWGA-VVGIGAALGPLLGGLLLELfGWRWIfliNVPIGLVALLLARTFSGAVL 175
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
14-190 |
2.31e-03 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 39.87 E-value: 2.31e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435803813 14 AIAIACVAFYAIPLGVVAnqagLFATPVMEEFGWSRTDATLYMTIQPWVAAICTPFAGKLISRFNPRWVMTAAAAVFGLA 93
Cdd:cd17504 185 TALLAGFGMFMVFQLLPQ----LLQLPTPTGFGLGITEAGLLLLPGALVMLIAGPLAGRLIARVGPRRVLLIGLVISAVG 260
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435803813 94 SLACAWF-TEPWQWNVYGVLYGASAAFwMYIATPTFI-------NRWFAKSNGTVIGTIG------VCASLIGAFMSPVI 159
Cdd:cd17504 261 LLLLALLhSSLWALVVALLLIGIGLGL-AFASLPNIVvesvppdRTGIATGMNTVLRTIGsaigpaIAGAILTTYTVSIT 339
|
170 180 190
....*....|....*....|....*....|.
gi 1435803813 160 QGWISGYGWHTARIIISVIALVASVVLTAAL 190
Cdd:cd17504 340 SGGVPTEGAYVLAFLIGAALALAALLLSLLI 370
|
|
| PRK11663 |
PRK11663 |
glucose-6-phosphate receptor/MFS transporter UhpC; |
37-342 |
2.48e-03 |
|
glucose-6-phosphate receptor/MFS transporter UhpC;
Pssm-ID: 183266 [Multi-domain] Cd Length: 434 Bit Score: 40.08 E-value: 2.48e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435803813 37 FATPVM-EEFGWSRTDATLYMTIQPWVAAICTPFAGKLISRFNPRWVMTAAAAVFGLASLACAWFTEPWqwnVYGVLYGA 115
Cdd:PRK11663 44 AAMPEMlADLGLSRSDIGLLATLFYITYGVSKFVSGIVSDRSNARYFMGIGLIATGIINILFGFSSSLW---AFALLWVL 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435803813 116 SAAF--WMYIATPTFINRWFAKSNGTVIGTIGVCASLIGAFMSPVIQGWIS-GYGWHTARIIISVIALVASVVLTAALlR 192
Cdd:PRK11663 121 NAFFqgWGWPVCAKLLTAWYSRTERGGWWAIWNTAHNVGGALIPLVVGAIAlHYGWRYGMMIAGIIAIVVGLFLCWRL-R 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435803813 193 ESPEKMGvLPwgygsaEVAAAKSDAKSVIEVSADEGVTAAQARK-----NPALWLLII-MAGFFVVAAGMMQQFSSYAST 266
Cdd:PRK11663 200 DKPQAMG-LP------SVGEWRHDALELAQQQEGAGLSRKEILTkyvllNPYIWLLSFsYVLVYVVRAAINDWGNLYMSE 272
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435803813 267 GALGAAVGA-LGVTVCMIGQLFGKFGLGWLCDHTGARISGVVASIFgALGIAIVL----------FSVDSAMMFYVGVFL 335
Cdd:PRK11663 273 TLGVDLVTAnSAVSMFELGGFIGALVAGWGSDKLFNGNRGPMNLIF-AAGILLSVgslwlmpfasYVMQAACFFTIGFFV 351
|
330
....*....|.
gi 1435803813 336 FG----IGFAA 342
Cdd:PRK11663 352 FGpqmlIGMAA 362
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
41-413 |
4.55e-03 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 39.10 E-value: 4.55e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435803813 41 VMEEFGWSRTDATLYMTIQPWVAAICTPFAGKLISRFNPRWVMTAAAAVFGLASLACAWFTEPWQWNVYGVLYGASAAFW 120
Cdd:cd17504 22 IQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVLIAGRALQGIGGAVF 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435803813 121 ---MYIATPTFINRWFAKSNGTVIGTIGVcASLIGAFMSPVIqgwISGYGWHTARIIISVIALVASVVLTAALLRespek 197
Cdd:cd17504 102 plaFALVREEFPPERVPVAQGILSATFGI-GAGIGLPLGGWI---VQHLGWRWIFWTAAPVAVLLAALVPLIDLR----- 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435803813 198 mgvlpwgygsaevaaaksdaksvievsadegvtaaqARKNPALWLLIIMAGFFVVAAGMMQQFSSY------ASTGALGA 271
Cdd:cd17504 173 ------------------------------------LLRRRNVLLANITALLAGFGMFMVFQLLPQllqlptPTGFGLGI 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435803813 272 AVGALGVTVCMIGQLFGKFGLGWLCDHTGARISGVVASIFGALGIAIVLFSVDSAMMFYVGVFLFGIGFAALNIVPPMAC 351
Cdd:cd17504 217 TEAGLLLLPGALVMLIAGPLAGRLIARVGPRRVLLIGLVISAVGLLLLALLHSSLWALVVALLLIGIGLGLAFASLPNIV 296
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1435803813 352 RQAFGQKDYANIFSMVATGLNVFSGFSAIIYAQIFDI------------TGSFAGCFWLIIGFYVVTLICSLVI 413
Cdd:cd17504 297 VESVPPDRTGIATGMNTVLRTIGSAIGPAIAGAILTTytvsitsggvptEGAYVLAFLIGAALALAALLLSLLI 370
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
27-113 |
4.96e-03 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 38.71 E-value: 4.96e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435803813 27 LGVVANQAGLFATPVM------EEFGWSRTDATLYMTIQPWVAAICTPFAGKLISRFNPRWVMTAAAAVFGLASLACAWF 100
Cdd:cd17503 185 LLSFLLGLGLFGAMFLlplylqNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAGLLLLALGTLLLAFL 264
|
90
....*....|...
gi 1435803813 101 TEPWQWNVYGVLY 113
Cdd:cd17503 265 TPDTSLWLIILPL 277
|
|
| MFS_MCT7 |
cd17422 |
Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters; ... |
13-192 |
5.47e-03 |
|
Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 7 (MCT7) is also called Solute carrier family 16 member 6 (SLC16A6). Zebrafish MCT7 is required for hepatocyte secretion of ketone bodies during fasting; it has been shown to be a selective transporter of the major ketone body beta-hydroxybutyrate, whose abundance is increased during fasting. MCT7 is expressed in the brain, pancreas, muscle, and prostate. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340980 [Multi-domain] Cd Length: 363 Bit Score: 38.58 E-value: 5.47e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435803813 13 WAIAIACVAFYAIPLGVVANqAGLFATPVMEEFGWSRTDATLYMTIQPWVAAICTPFAGKLISRFNPRWVMTAAAAVFGL 92
Cdd:cd17422 2 WAVAVAFFFVEVFTYGVIKS-FGVFFNDLMSYFNETNSRVSWIISICVFVMTFTAPLSTVLSNRFGHRPVVMVGGLLISL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435803813 93 ASLACAWFTE-PWQWNVYGVLYGASAAFwMYIATPTFINRWFAKSNGTVIGTIGVCASLIGAFMSPVIQGWISGYGWHTA 171
Cdd:cd17422 81 GMITASFASSiVEMYLTIGIISGLGYCF-TFLPTVTILSQYFKKRRSLVTAIASTGECFAVFAFAPAFTALKESIGWRYC 159
|
170 180
....*....|....*....|.
gi 1435803813 172 RIIISVIALvaSVVLTAALLR 192
Cdd:cd17422 160 LLVVGALQL--NIVVCGALLR 178
|
|
| MFS_MFSD6 |
cd17335 |
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ... |
69-192 |
6.53e-03 |
|
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 38.33 E-value: 6.53e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435803813 69 FAGKLISRFNPRWVMTAAAAVFGLASLACAWFTEPWQWNVYGVLYGAS-AAFWmyIATPTFINRWFAKSNGTVIGTI--G 145
Cdd:cd17335 252 FSSRLIQRFGHVGLLYLGLLAYVVRWLLYSFLENPWLVLPIELLHGLTfALVW--AAAVSYASAAAPPGLRATAQGLlqG 329
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 1435803813 146 VCASLIGAFMSpviqgWISGYGWHT--ARIIISVIALVASVVLTAALLR 192
Cdd:cd17335 330 LYFGLGGGLGS-----LIGGYLYEAfgARTTFRFFAIAALAGLLAFFLI 373
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
21-129 |
7.57e-03 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 38.38 E-value: 7.57e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435803813 21 AFYAIPLGVVANQAGLFATPVMEEFGWSRTDATLYMTIQPWVAAICTPFAGKLISRFNPRWVMTAAAAVFGLASLACAWF 100
Cdd:cd17327 239 FLFFFCSQITNNGISNFLPLILKSLGFYSLQTNLLSVPIGALGAVSLLIAALLSDRFKKRGLFAIFACVLALVGSIILLA 318
|
90 100
....*....|....*....|....*....
gi 1435803813 101 tepWQWNVYGVLYGASAAFWMYIATPTFI 129
Cdd:cd17327 319 ---APNPPGAYFAAYILGGGSYAGFPILL 344
|
|
| MFS_YjiJ |
cd06180 |
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ... |
69-342 |
7.99e-03 |
|
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 38.05 E-value: 7.99e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435803813 69 FAGKLISRFNPRWVMTAAAAVFGLASLACAWFTEPWQWNVYGVLYGASAAFwMYIATPTFINRWFAKSNGTVIGTIGVCA 148
Cdd:cd06180 53 LASFLRRRGRARRLIRGGLLLTVLLLAAMALTSGFAALLALRFLAGAASAF-VFVFGSNLVLHHATAAGRGHLIGLLFAG 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435803813 149 SLIGAFMSPVIQGWISGYGWHTARIIIsvIALVASVVLTAALLRESPEKMGVLPwgygsaevaaaksdaksviEVSADEg 228
Cdd:cd06180 132 VGLGIALSGLLVPAGLGGGLSWRAGWL--ALALLSAVLLLLSFLLLRRGPSAPT-------------------EASAAE- 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435803813 229 vtaAQARKNPALWLLIIMAGFFVVAAGMMQQF-SSYASTGALGAAVGALGVTVCMIGQLFGKFGLGWLCDHTGARISGVV 307
Cdd:cd06180 190 ---SAPGLNRPLWRLALAYGLFGFGYIITATFlPLIARETGAGSLLAGLLWSLFGLAAVPSCFLWGALSDRWGTRRALAA 266
|
250 260 270
....*....|....*....|....*....|....*
gi 1435803813 308 ASIFGALGIAIVLFSvDSAMMFYVGVFLFGIGFAA 342
Cdd:cd06180 267 NLLVQAVGVLLPLLS-PGPAGLVLSAVLFGGTFMA 300
|
|
| |
