|
Name |
Accession |
Description |
Interval |
E-value |
| PRK14093 |
PRK14093 |
UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanine ligase; ... |
10-480 |
0e+00 |
|
UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanine ligase; Provisional
Pssm-ID: 184501 [Multi-domain] Cd Length: 479 Bit Score: 554.38 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1442385866 10 LWTSDAMVEVMEGRPFGNLPAGVTGISIDSRALKPGEAFFAIKGEQFDGHDFATAAMAAGAGLLVVAEHRLPAFGnTKVP 89
Cdd:PRK14093 6 LWTSDAMAEAMGATRSGALPRDVTGISIDSRTLAPGDAYFAIKGDVHDGHAFVAAALKAGAALAVVERAQRDKFA-ADAP 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1442385866 90 MIVVEDVLEALIRLGIAARARSKAQIIAVTGSVGKTTTKEALRHVLSDVGKVHASAASFNNHWGVPLTLARMPADVDYGV 169
Cdd:PRK14093 85 LLVVDDVLAALRDLGRAARARLEAKVIAVTGSVGKTSTKEALRGVLGAQGETHASVASFNNHWGVPLSLARCPADARFAV 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1442385866 170 FEIGMNHHGEIRPLVKMVRPHVALITLIAPAHLGHFANLEEIAVAKAEIFEGIVPGGYALLNRDDKRFRQLQELAEKAGV 249
Cdd:PRK14093 165 FEIGMNHAGEIEPLVKMVRPHVAIITTVEPVHLEFFSGIEAIADAKAEIFTGLEPGGAAVLNRDNPQFDRLAASARAAGI 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1442385866 250 EHIATFGENARADYRLRDVKLHPTCSCMTVKIGTHEAAVKVGIPGRHVVQNMLAVLGAAHLVGADIAKVMMAMATLSAQG 329
Cdd:PRK14093 245 ARIVSFGADEKADARLLDVALHADCSAVHADILGHDVTYKLGMPGRHIAMNSLAVLAAAELAGADLALAALALSQVQPAA 324
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1442385866 330 GRGARHVLQHPEGAFTLIDESYNANPTSMRAALSLLhSTVPEGSRGRRIAVLGDMVEFGRQSCKLHADLARPIVDAEVNT 409
Cdd:PRK14093 325 GRGVRHTLEVGGGEATLIDESYNANPASMAAALGVL-GRAPVGPQGRRIAVLGDMLELGPRGPELHRGLAEAIRANAIDL 403
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1442385866 410 LFIGGSEMSVLKNALPVEIQTEYRQSTDELLPLVVKAVRPGDVVMVKSSNRTGFSKIVKALIAQFPPVEAA 480
Cdd:PRK14093 404 VFCCGPLMRNLWDALSSGKRGGYAEDAAALESQVVAAIRAGDVIMVKGSLGSRMKTIVTALEKRFPGNAAL 474
|
|
| MurF |
COG0770 |
UDP-N-acetylmuramyl pentapeptide synthase [Cell wall/membrane/envelope biogenesis]; ... |
10-475 |
9.46e-178 |
|
UDP-N-acetylmuramyl pentapeptide synthase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramyl pentapeptide synthase is part of the Pathway/BioSystem: Mureine biosynthesis
Pssm-ID: 440533 [Multi-domain] Cd Length: 451 Bit Score: 505.79 E-value: 9.46e-178
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1442385866 10 LWTSDAMVEVMEGRPFGNLPAGVTGISIDSRALKPGEAFFAIKGEQFDGHDFATAAMAAGAGLLVVaEHRLPAfgntKVP 89
Cdd:COG0770 2 LLTLAEIAEATGGRLIGDPDLVVTGVSTDSRKIKPGDLFVALKGERFDGHDFVAQALAKGAAAALV-SRPLPA----DLP 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1442385866 90 MIVVEDVLEALIRLGIAARARSKAQIIAVTGSVGKTTTKEALRHVLSDVGKVHASAASFNNHWGVPLTLARMPADVDYGV 169
Cdd:COG0770 77 LIVVDDTLKALQQLAAAHRARFNIPVIAITGSNGKTTTKEMLAAVLSTKGKVLATPGNFNNEIGVPLTLLRLPEDHEFAV 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1442385866 170 FEIGMNHHGEIRPLVKMVRPHVALITLIAPAHLGHFANLEEIAVAKAEIFEGIVPGGYALLNRDDKRFRQLQELAEkagv 249
Cdd:COG0770 157 LEMGMNHPGEIAYLARIARPDIAVITNIGPAHLEGFGSLEGIARAKGEIFEGLPPGGVAVLNADDPLLAALAERAK---- 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1442385866 250 EHIATFGENARADYRLRDVKLHPTCSCMTVKIGTHEAAVKVGIPGRHVVQNMLAVLGAAHLVGADIAKVMMAMATLSAQG 329
Cdd:COG0770 233 ARVLTFGLSEDADVRAEDIELDEDGTRFTLHTPGGELEVTLPLPGRHNVSNALAAAAVALALGLDLEEIAAGLAAFQPVK 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1442385866 330 GRGARHVLQhpeGAFTLIDESYNANPTSMRAALSLLHSTvpeGSRGRRIAVLGDMVEFGRQSCKLHADLARPIVDAEVNT 409
Cdd:COG0770 313 GRLEVIEGA---GGVTLIDDSYNANPDSMKAALDVLAQL---PGGGRRIAVLGDMLELGEESEELHREVGELAAELGIDR 386
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1442385866 410 LFIGGSEMSVLKNALpVEIQTEYRQSTDELLPLVVKAVRPGDVVMVKSSNRTGFSKIVKALIAQFP 475
Cdd:COG0770 387 LFTVGELARAIAEAA-GGERAEHFEDKEELLAALKALLRPGDVVLVKGSRGMGLERVVEALKEGAA 451
|
|
| murF |
TIGR01143 |
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; This family consists of the ... |
37-470 |
1.39e-123 |
|
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; This family consists of the strictly bacterial MurF gene of peptidoglycan biosynthesis. This enzyme is almost always UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanyl ligase, but in a few species, MurE adds lysine rather than diaminopimelate. This enzyme acts on the product from MurE activity, and so is also subfamily rather than equivalog. Staphylococcus aureus is an example of species in this MurF protein would differ. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 273468 [Multi-domain] Cd Length: 417 Bit Score: 366.59 E-value: 1.39e-123
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1442385866 37 IDSRALKPGEAFFAIKGEQFDGHDFATAAMAAGAGLLVVAEHRLPAFGntkVPMIVVEDVLEALIRLGIAARARSKAQII 116
Cdd:TIGR01143 1 TDSRAIKPGDLFIALKGERFDGHDFVEQALAAGAVAVVVDREVGPDNG---LPQILVDDTLEALQALARAKRAKFSGKVI 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1442385866 117 AVTGSVGKTTTKEALRHVLSDVGKVHASAASFNNHWGVPLTLARMPADVDYGVFEIGMNHHGEIRPLVKMVRPHVALITL 196
Cdd:TIGR01143 78 GITGSSGKTTTKEMLAAILSHKYKVFATPGNFNNEIGLPLTLLRAPGDHDYAVLEMGASHPGEIAYLAEIAKPDIAVITN 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1442385866 197 IAPAHLGHFANLEEIAVAKAEIFEGIVPGGYALLNRDDKRFRQL-QELAEKAgvehIATFGENaRADYRLRDVKLHPTcS 275
Cdd:TIGR01143 158 IGPAHLEGFGSLEGIAEAKGEILQGLKENGIAVINADDPAFADLaKRLPNRN----ILSFGFE-GGDFVAKDISYSAL-G 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1442385866 276 CMTVKIGTH--EAAVKVGIPGRHVVQNMLAVLGAAHLVGADIAKVMMAMATLSAQGGRGarhVLQHPEGaFTLIDESYNA 353
Cdd:TIGR01143 232 STSFTLVAPggEFEVSLPLLGRHNVMNALAAAALALELGIPLEEIAEGLAELKLVKGRF---EVQTKNG-LTLIDDTYNA 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1442385866 354 NPTSMRAALSLLHSTvpegsRGRRIAVLGDMVEFGRQSCKLHADLARPIVDAEVNTLFIGGSEMSVLKNALPVEIQteYR 433
Cdd:TIGR01143 308 NPDSMRAALDALARF-----PGKKILVLGDMAELGEYSEELHAEVGRYANSLGIDLVFLVGEEAAVIYDSFGKQGK--HF 380
|
410 420 430
....*....|....*....|....*....|....*..
gi 1442385866 434 QSTDELLPLVVKAVRPGDVVMVKSSNRTGFSKIVKAL 470
Cdd:TIGR01143 381 ADKDELLAFLKTLVRKGDVVLVKGSRSVKLEKVVEAL 417
|
|
| Mur_ligase_M |
pfam08245 |
Mur ligase middle domain; |
118-308 |
9.36e-62 |
|
Mur ligase middle domain;
Pssm-ID: 462409 [Multi-domain] Cd Length: 199 Bit Score: 199.84 E-value: 9.36e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1442385866 118 VTGSVGKTTTKEALRHVLSDVGKVHASAA--------SFNNHWGVPLTLARMP-ADVDYGVFEIGMNHHGEIRpLVKMVR 188
Cdd:pfam08245 1 VTGTNGKTTTTELIAAILSLAGGVIGTIGtyigksgnTTNNAIGLPLTLAEMVeAGAEYAVLEVSSHGLGEGR-LSGLLK 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1442385866 189 PHVALITLIAPAHLGHFANLEEIAVAKAEIFEGIVPGGYALLNRDDKRFRQLQELAEKAGVEHIaTFGENARADYRLRDV 268
Cdd:pfam08245 80 PDIAVFTNISPDHLDFHGTMENYAKAKAELFEGLPEDGIAVINADDPYGAFLIAKLKKAGVRVI-TYGIEGEADLRAANI 158
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 1442385866 269 KLHPTCS---CMTVKIGTHEaaVKVGIPGRHVVQNMLAVLGAA 308
Cdd:pfam08245 159 ELSSDGTsfdLFTVPGGELE--IEIPLLGRHNVYNALAAIAAA 199
|
|
| F430_CfbE |
NF033197 |
coenzyme F430 synthase; Members of this family are coenzyme F430 synthase, involving in ... |
115-361 |
1.27e-06 |
|
coenzyme F430 synthase; Members of this family are coenzyme F430 synthase, involving in synthesizing coenzyme F430, which is used in methanogens by coenzyme M reductase. Members of this family are restricted to archaeal methanogens, and resemble (and may be misannotated as) MurD, an enzyme of bacterial cell wall biosynthesis.
Pssm-ID: 467992 [Multi-domain] Cd Length: 419 Bit Score: 50.40 E-value: 1.27e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1442385866 115 IIAVTGSVGKTTTKEALRHVLSDVGKV-HASAASFNNHWGV--------P---LTLAR-----MPADVDYGVFEIGmnhh 177
Cdd:NF033197 94 FIEITGVKGKTTTAELLAHILSDEYVLlHTSRGTERYPEGElsnkgsitPasiLNALElaeeiGIDDYGFLIFEVS---- 169
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1442385866 178 geirpLVKMVRPHVALITliapahlghfaNLEE---IA-------VAKAEIFEGIVPGGYALLNRDDKRFRQLQELAEKA 247
Cdd:NF033197 170 -----LGGTGAGDVGIIT-----------NILEdypIAggkrsasAAKLQSLKNAKVGSINVADLGIYINGKNKLVITVA 233
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1442385866 248 GVEhIATFgenaradYRLRDVKlhptcscmtvkiGTHEAAVKVGIPGRHVVQNMLAVLGAAHLVGADIAKVMMAMATLSA 327
Cdd:NF033197 234 GVE-ILSK-------YPLRFKY------------GNTEFEFNPLLFGPHYRENSLFAIEAALNLGVDPEDIISALKGFKG 293
|
250 260 270
....*....|....*....|....*....|....*
gi 1442385866 328 QGGRGARHVlqhpEGAFTLIDesyNANP-TSMRAA 361
Cdd:NF033197 294 LPGRMAVKK----EGGVVIVD---NINPgLNVKAI 321
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PRK14093 |
PRK14093 |
UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanine ligase; ... |
10-480 |
0e+00 |
|
UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanine ligase; Provisional
Pssm-ID: 184501 [Multi-domain] Cd Length: 479 Bit Score: 554.38 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1442385866 10 LWTSDAMVEVMEGRPFGNLPAGVTGISIDSRALKPGEAFFAIKGEQFDGHDFATAAMAAGAGLLVVAEHRLPAFGnTKVP 89
Cdd:PRK14093 6 LWTSDAMAEAMGATRSGALPRDVTGISIDSRTLAPGDAYFAIKGDVHDGHAFVAAALKAGAALAVVERAQRDKFA-ADAP 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1442385866 90 MIVVEDVLEALIRLGIAARARSKAQIIAVTGSVGKTTTKEALRHVLSDVGKVHASAASFNNHWGVPLTLARMPADVDYGV 169
Cdd:PRK14093 85 LLVVDDVLAALRDLGRAARARLEAKVIAVTGSVGKTSTKEALRGVLGAQGETHASVASFNNHWGVPLSLARCPADARFAV 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1442385866 170 FEIGMNHHGEIRPLVKMVRPHVALITLIAPAHLGHFANLEEIAVAKAEIFEGIVPGGYALLNRDDKRFRQLQELAEKAGV 249
Cdd:PRK14093 165 FEIGMNHAGEIEPLVKMVRPHVAIITTVEPVHLEFFSGIEAIADAKAEIFTGLEPGGAAVLNRDNPQFDRLAASARAAGI 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1442385866 250 EHIATFGENARADYRLRDVKLHPTCSCMTVKIGTHEAAVKVGIPGRHVVQNMLAVLGAAHLVGADIAKVMMAMATLSAQG 329
Cdd:PRK14093 245 ARIVSFGADEKADARLLDVALHADCSAVHADILGHDVTYKLGMPGRHIAMNSLAVLAAAELAGADLALAALALSQVQPAA 324
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1442385866 330 GRGARHVLQHPEGAFTLIDESYNANPTSMRAALSLLhSTVPEGSRGRRIAVLGDMVEFGRQSCKLHADLARPIVDAEVNT 409
Cdd:PRK14093 325 GRGVRHTLEVGGGEATLIDESYNANPASMAAALGVL-GRAPVGPQGRRIAVLGDMLELGPRGPELHRGLAEAIRANAIDL 403
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1442385866 410 LFIGGSEMSVLKNALPVEIQTEYRQSTDELLPLVVKAVRPGDVVMVKSSNRTGFSKIVKALIAQFPPVEAA 480
Cdd:PRK14093 404 VFCCGPLMRNLWDALSSGKRGGYAEDAAALESQVVAAIRAGDVIMVKGSLGSRMKTIVTALEKRFPGNAAL 474
|
|
| MurF |
COG0770 |
UDP-N-acetylmuramyl pentapeptide synthase [Cell wall/membrane/envelope biogenesis]; ... |
10-475 |
9.46e-178 |
|
UDP-N-acetylmuramyl pentapeptide synthase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramyl pentapeptide synthase is part of the Pathway/BioSystem: Mureine biosynthesis
Pssm-ID: 440533 [Multi-domain] Cd Length: 451 Bit Score: 505.79 E-value: 9.46e-178
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1442385866 10 LWTSDAMVEVMEGRPFGNLPAGVTGISIDSRALKPGEAFFAIKGEQFDGHDFATAAMAAGAGLLVVaEHRLPAfgntKVP 89
Cdd:COG0770 2 LLTLAEIAEATGGRLIGDPDLVVTGVSTDSRKIKPGDLFVALKGERFDGHDFVAQALAKGAAAALV-SRPLPA----DLP 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1442385866 90 MIVVEDVLEALIRLGIAARARSKAQIIAVTGSVGKTTTKEALRHVLSDVGKVHASAASFNNHWGVPLTLARMPADVDYGV 169
Cdd:COG0770 77 LIVVDDTLKALQQLAAAHRARFNIPVIAITGSNGKTTTKEMLAAVLSTKGKVLATPGNFNNEIGVPLTLLRLPEDHEFAV 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1442385866 170 FEIGMNHHGEIRPLVKMVRPHVALITLIAPAHLGHFANLEEIAVAKAEIFEGIVPGGYALLNRDDKRFRQLQELAEkagv 249
Cdd:COG0770 157 LEMGMNHPGEIAYLARIARPDIAVITNIGPAHLEGFGSLEGIARAKGEIFEGLPPGGVAVLNADDPLLAALAERAK---- 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1442385866 250 EHIATFGENARADYRLRDVKLHPTCSCMTVKIGTHEAAVKVGIPGRHVVQNMLAVLGAAHLVGADIAKVMMAMATLSAQG 329
Cdd:COG0770 233 ARVLTFGLSEDADVRAEDIELDEDGTRFTLHTPGGELEVTLPLPGRHNVSNALAAAAVALALGLDLEEIAAGLAAFQPVK 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1442385866 330 GRGARHVLQhpeGAFTLIDESYNANPTSMRAALSLLHSTvpeGSRGRRIAVLGDMVEFGRQSCKLHADLARPIVDAEVNT 409
Cdd:COG0770 313 GRLEVIEGA---GGVTLIDDSYNANPDSMKAALDVLAQL---PGGGRRIAVLGDMLELGEESEELHREVGELAAELGIDR 386
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1442385866 410 LFIGGSEMSVLKNALpVEIQTEYRQSTDELLPLVVKAVRPGDVVMVKSSNRTGFSKIVKALIAQFP 475
Cdd:COG0770 387 LFTVGELARAIAEAA-GGERAEHFEDKEELLAALKALLRPGDVVLVKGSRGMGLERVVEALKEGAA 451
|
|
| murF |
TIGR01143 |
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; This family consists of the ... |
37-470 |
1.39e-123 |
|
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; This family consists of the strictly bacterial MurF gene of peptidoglycan biosynthesis. This enzyme is almost always UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanyl ligase, but in a few species, MurE adds lysine rather than diaminopimelate. This enzyme acts on the product from MurE activity, and so is also subfamily rather than equivalog. Staphylococcus aureus is an example of species in this MurF protein would differ. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 273468 [Multi-domain] Cd Length: 417 Bit Score: 366.59 E-value: 1.39e-123
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1442385866 37 IDSRALKPGEAFFAIKGEQFDGHDFATAAMAAGAGLLVVAEHRLPAFGntkVPMIVVEDVLEALIRLGIAARARSKAQII 116
Cdd:TIGR01143 1 TDSRAIKPGDLFIALKGERFDGHDFVEQALAAGAVAVVVDREVGPDNG---LPQILVDDTLEALQALARAKRAKFSGKVI 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1442385866 117 AVTGSVGKTTTKEALRHVLSDVGKVHASAASFNNHWGVPLTLARMPADVDYGVFEIGMNHHGEIRPLVKMVRPHVALITL 196
Cdd:TIGR01143 78 GITGSSGKTTTKEMLAAILSHKYKVFATPGNFNNEIGLPLTLLRAPGDHDYAVLEMGASHPGEIAYLAEIAKPDIAVITN 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1442385866 197 IAPAHLGHFANLEEIAVAKAEIFEGIVPGGYALLNRDDKRFRQL-QELAEKAgvehIATFGENaRADYRLRDVKLHPTcS 275
Cdd:TIGR01143 158 IGPAHLEGFGSLEGIAEAKGEILQGLKENGIAVINADDPAFADLaKRLPNRN----ILSFGFE-GGDFVAKDISYSAL-G 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1442385866 276 CMTVKIGTH--EAAVKVGIPGRHVVQNMLAVLGAAHLVGADIAKVMMAMATLSAQGGRGarhVLQHPEGaFTLIDESYNA 353
Cdd:TIGR01143 232 STSFTLVAPggEFEVSLPLLGRHNVMNALAAAALALELGIPLEEIAEGLAELKLVKGRF---EVQTKNG-LTLIDDTYNA 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1442385866 354 NPTSMRAALSLLHSTvpegsRGRRIAVLGDMVEFGRQSCKLHADLARPIVDAEVNTLFIGGSEMSVLKNALPVEIQteYR 433
Cdd:TIGR01143 308 NPDSMRAALDALARF-----PGKKILVLGDMAELGEYSEELHAEVGRYANSLGIDLVFLVGEEAAVIYDSFGKQGK--HF 380
|
410 420 430
....*....|....*....|....*....|....*..
gi 1442385866 434 QSTDELLPLVVKAVRPGDVVMVKSSNRTGFSKIVKAL 470
Cdd:TIGR01143 381 ADKDELLAFLKTLVRKGDVVLVKGSRSVKLEKVVEAL 417
|
|
| PRK11929 |
PRK11929 |
bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE ... |
21-471 |
4.46e-91 |
|
bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE/UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase MurF;
Pssm-ID: 237025 [Multi-domain] Cd Length: 958 Bit Score: 297.39 E-value: 4.46e-91
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1442385866 21 EGRPFGNLPAGVTGISIDSRALKPGEAFFAIKGEQFDGHDFATAAMAAGAGLLVVAEHRLPAfgntKVPMIVVEDVLEAL 100
Cdd:PRK11929 515 SNSLQINSLPHAGAVSTDSRSVGRGELFVALRGENFDGHDYLPQAFAAGACAAVVERQVADV----DLPQIVVDDTRAAL 590
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1442385866 101 IRLGIAARARSKAQIIAVTGSVGKTTTKEALRHVLSD---VGKVHASAASFNNHWGVPLTLARMPADVDYGVFEIGMNHH 177
Cdd:PRK11929 591 GRLATAWRARFSLPVVAITGSNGKTTTKEMIAAILAAwqgEDRVLATEGNFNNEIGVPLTLLRLRAQHRAAVFELGMNHP 670
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1442385866 178 GEIRPLVKMVRPHVALITLIAPAHLGHFANLEEIAVAKAEIFEGIVPGGYALLNRDDkrfRQLQELAEKAGVEHIATF-- 255
Cdd:PRK11929 671 GEIAYLAAIAAPTVALVTNAQREHQEFMHSVEAVARAKGEIIAALPEDGVAVVNGDD---PYTAIWAKLAGARRVLRFgl 747
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1442385866 256 --GENARADYRLRDVKLHPTCSCMT-VKIGTHEAAVKVGIPGRHVVQNMLAVLGAAHLVGADIAKVMMAMATLSAQGGRG 332
Cdd:PRK11929 748 qpGADVYAEKIAKDISVGEAGGTRCqVVTPAGSAEVYLPLIGEHNLRNALAAIACALAAGASLKQIRAGLERFQPVAGRM 827
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1442385866 333 ARHVLqhpEGAFTLIDESYNANPTSMRAALSLLhSTVPegsRGRRIAVLGDMVEFGRQSCKLHADLARPIVDAEVNTLFI 412
Cdd:PRK11929 828 QRRRL---SCGTRIIDDTYNANPDSMRAAIDVL-AELP---NGPRALVLGDMLELGDNGPAMHREVGKYARQLGIDALIT 900
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*....
gi 1442385866 413 GGSEMSVLKNALPvEIQTEYRQSTDELLPLVVKAVRPGDVVMVKSSNRTGFSKIVKALI 471
Cdd:PRK11929 901 LGEAARDAAAAFG-AGARGVCASVDEIIAALRGALPEGDSVLIKGSRFMRLERVVDALS 958
|
|
| murF |
PRK10773 |
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed |
32-395 |
6.87e-68 |
|
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed
Pssm-ID: 182718 [Multi-domain] Cd Length: 453 Bit Score: 224.14 E-value: 6.87e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1442385866 32 VTGISIDSRALKPGEAFFAIKGEQFDGHDFATAAMAAGAGLLVVAEhRLPafgnTKVPMIVVEDVLEALIRLGIAARARS 111
Cdd:PRK10773 24 IDAVTTDTRKVTPGCLFVALKGERFDAHDFADDAKAAGAGALLVSR-PLD----IDLPQLVVKDTRLAFGQLAAWVRQQV 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1442385866 112 KAQIIAVTGSVGKTTTKEALRHVLSDVGKVHASAASFNNHWGVPLTLARMPADVDYGVFEIGMNHHGEIRPLVKMVRPHV 191
Cdd:PRK10773 99 PARVVALTGSSGKTSVKEMTAAILRQCGNTLYTAGNLNNDIGVPLTLLRLTPEHDYAVIELGANHQGEIAYTVSLTRPEA 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1442385866 192 ALITLIAPAHLGHFANLEEIAVAKAEIFEGIVPGGYALLNRDDKRFRQLQE-LAEKAgvehIATFGENAR--ADYRLRDV 268
Cdd:PRK10773 179 ALVNNLAAAHLEGFGSLAGVAKAKGEIFSGLPENGIAIMNADSNDWLNWQSvIGSKT----VWRFSPNAAnsVDFTATNI 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1442385866 269 KLHPTCSCMTVKIGTHEAAVKVGIPGRHVVQNMLAVLGAAHLVGADIAKVMMAMATLSAQGGRgaRHVLQHPEGAfTLID 348
Cdd:PRK10773 255 HVTSHGTEFTLHTPTGSVDVLLPLPGRHNIANALAAAALAMSVGATLDAVKAGLANLKAVPGR--LFPIQLAEGQ-LLLD 331
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 1442385866 349 ESYNANPTSMRAALSLLhSTVPegsrGRRIAVLGDMVEFGRQSCKLH 395
Cdd:PRK10773 332 DSYNANVGSMTAAAQVL-AEMP----GYRVMVVGDMAELGAESEACH 373
|
|
| Mur_ligase_M |
pfam08245 |
Mur ligase middle domain; |
118-308 |
9.36e-62 |
|
Mur ligase middle domain;
Pssm-ID: 462409 [Multi-domain] Cd Length: 199 Bit Score: 199.84 E-value: 9.36e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1442385866 118 VTGSVGKTTTKEALRHVLSDVGKVHASAA--------SFNNHWGVPLTLARMP-ADVDYGVFEIGMNHHGEIRpLVKMVR 188
Cdd:pfam08245 1 VTGTNGKTTTTELIAAILSLAGGVIGTIGtyigksgnTTNNAIGLPLTLAEMVeAGAEYAVLEVSSHGLGEGR-LSGLLK 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1442385866 189 PHVALITLIAPAHLGHFANLEEIAVAKAEIFEGIVPGGYALLNRDDKRFRQLQELAEKAGVEHIaTFGENARADYRLRDV 268
Cdd:pfam08245 80 PDIAVFTNISPDHLDFHGTMENYAKAKAELFEGLPEDGIAVINADDPYGAFLIAKLKKAGVRVI-TYGIEGEADLRAANI 158
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 1442385866 269 KLHPTCS---CMTVKIGTHEaaVKVGIPGRHVVQNMLAVLGAA 308
Cdd:pfam08245 159 ELSSDGTsfdLFTVPGGELE--IEIPLLGRHNVYNALAAIAAA 199
|
|
| PRK11930 |
PRK11930 |
putative bifunctional UDP-N-acetylmuramoyl-tripeptide:D-alanyl-D-alanine ligase/alanine ... |
18-470 |
9.34e-48 |
|
putative bifunctional UDP-N-acetylmuramoyl-tripeptide:D-alanyl-D-alanine ligase/alanine racemase; Provisional
Pssm-ID: 237026 [Multi-domain] Cd Length: 822 Bit Score: 176.30 E-value: 9.34e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1442385866 18 EVMEGRPFGNLPAGVTGISIDSRALK-PGEA-FFAIKGEQFDGHDFATAAMAAGAGLLVVAEHRLPAFGNTKVPMIVVED 95
Cdd:PRK11930 10 GILGAEGLGDKDAIIDQILTDSRSLSfPENTlFFALKGERNDGHRYIQELYEKGVRNFVVSEEKHPEESYPDANFLKVKD 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1442385866 96 VLEALIRLgiAARARSKAQI--IAVTGSVGKTTTKEALRHVLSDVGKVHASAASFNNHWGVPLTLARMPADVDYGVFEIG 173
Cdd:PRK11930 90 PLKALQEL--AAYHRSQFDIpvIGITGSNGKTIVKEWLYQLLSPDYNIVRSPRSYNSQIGVPLSVWQLNEEHELGIFEAG 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1442385866 174 MNHHGEIRPLVKMVRPHVALITLIAPAHLGHFANLEEIAVAKAEIFEGIVPGGYALLNRDdkrfrQLQELAEKAgvEHIA 253
Cdd:PRK11930 168 ISQPGEMEALQKIIKPTIGILTNIGGAHQENFRSIKQKIMEKLKLFKDCDVIIYNGDNEL-----ISSCITKSN--LTLK 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1442385866 254 TFG---ENARADYRLRDVKLHPTCSCMTVKIGTHEAAVKVGIPGRHVVQNMLAVLGAAHLVGADIAKVMMAMATLSAQGG 330
Cdd:PRK11930 241 LISwsrKDPEAPLYIPFVEKKEDHTVISYTYKGEDFHFEIPFIDDASIENLIHCIAVLLYLGYSADQIQERMARLEPVAM 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1442385866 331 RgaRHVLQHPEGAfTLIDESYNANPTSMRAALSLLHSTVPegsRGRRIAVLGDMVEFGRQSCKLHADLARPIVDAEVNTL 410
Cdd:PRK11930 321 R--LEVKEGINNC-TLINDSYNSDLQSLDIALDFLNRRSQ---SKKKTLILSDILQSGQSPEELYRKVAQLISKRGIDRL 394
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1442385866 411 FIGGSEMSVLKNALPVeIQTEYRQSTDELLPLVVKAVRPGDVVMVKSSNRTGFSKIVKAL 470
Cdd:PRK11930 395 IGIGEEISSEASKFEG-TEKEFFKTTEAFLKSFAFLKFRNELILVKGARKFEFEQITELL 453
|
|
| MurE |
COG0769 |
UDP-N-acetylmuramyl tripeptide synthase [Cell wall/membrane/envelope biogenesis]; ... |
34-382 |
1.14e-39 |
|
UDP-N-acetylmuramyl tripeptide synthase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramyl tripeptide synthase is part of the Pathway/BioSystem: Mureine biosynthesis
Pssm-ID: 440532 [Multi-domain] Cd Length: 459 Bit Score: 148.69 E-value: 1.14e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1442385866 34 GISIDSRALKPGEAFFAIKGEQFDGHDFataamaagagL---------LVVAEHRLpAFGNTKVPMIVVEDVLEALIRlg 104
Cdd:COG0769 1 GITYDSRKVKPGDLFVALPGARVDGHDF----------IaqaiargavAVVTEAPG-ALLAAGVPVIVVPDPRAALAL-- 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1442385866 105 IAAR----ARSKAQIIAVTGSVGKTTTKEALRHVLSDVGKvhaSAASF---NNHWGV-----------PLTLARMPAD-- 164
Cdd:COG0769 68 LAAAfyghPSQKLKLIGVTGTNGKTTTTYLLAQILRALGK---KTGLIgtvGNGIGGelipsslttpeALDLQRLLAEmv 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1442385866 165 ---VDYGVFE---IGMNHHgeiRplVKMVRPHVALITLIAPAHLGHFANLEEIAVAKAEIFEGIVPGGYALLNRDDKRFR 238
Cdd:COG0769 145 dagVTHVVMEvssHALDQG---R--VDGVRFDVAVFTNLTRDHLDYHGTMEAYFAAKARLFDQLGPGGAAVINADDPYGR 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1442385866 239 QLQELAEKagveHIATFGENARADYRLRDVKLHPTCSCMTVKIGTHEAAVKVGIPGRHVVQNMLAVLGAAHLVGADIAKV 318
Cdd:COG0769 220 RLAAAAPA----RVITYGLKADADLRATDIELSADGTRFTLVTPGGEVEVRLPLIGRFNVYNALAAIAAALALGIDLEEI 295
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1442385866 319 MMAMATLSAQGGRgaRHVLQHPEGAFTLIDesYNANPTSMRAALsllhSTVPEGSRGRRIAVLG 382
Cdd:COG0769 296 LAALEKLKGVPGR--MERVDGGQGPTVIVD--YAHTPDALENVL----EALRPHTKGRLIVVFG 351
|
|
| murE |
PRK00139 |
UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase; Provisional |
32-382 |
1.00e-30 |
|
UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase; Provisional
Pssm-ID: 234660 [Multi-domain] Cd Length: 460 Bit Score: 123.70 E-value: 1.00e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1442385866 32 VTGISIDSRALKPGEAFFAIKGEQFDGHDFATAAMAAGAGlLVVAEHrlPAFGNTKVPMIVVEDVLEALIRlgIAARA-- 109
Cdd:PRK00139 15 ITGLTYDSRKVKPGDLFVALPGHKVDGRDFIAQAIANGAA-AVVAEA--DGEAGTGVPVIIVPDLRKALAL--LAAAFyg 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1442385866 110 --RSKAQIIAVTGSVGKTTTKEALRHVLSDVGKvhaSAASF---NNHWG-----------VPLTLARMPAD-----VDYG 168
Cdd:PRK00139 90 hpSDKLKLIGVTGTNGKTTTAYLLAQILRLLGE---KTALIgtlGNGIGgelipsglttpDALDLQRLLAElvdagVTYA 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1442385866 169 VFEIgmNHHGeirpL----VKMVRPHVALITLIAPAHLGHFANLEEIAVAKAEIFEGivPGGYALLNRDDKRFRQLQELA 244
Cdd:PRK00139 167 AMEV--SSHA----LdqgrVDGLKFDVAVFTNLSRDHLDYHGTMEDYLAAKARLFSE--LGLAAVINADDEVGRRLLALP 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1442385866 245 EKAGVEHiatfgenARADYRLRDVKLHPTCSCMTVkigthEAAVKVGIPGRHVVQNMLAVLGAAHLVGADIAKVMMAMAT 324
Cdd:PRK00139 239 DAYAVSM-------AGADLRATDVEYTDSGQTFTL-----VTEVESPLIGRFNVSNLLAALAALLALGVPLEDALAALAK 306
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 1442385866 325 LsaQGGRGARHVLQHPEGAFTLIDesYNANPTSMRAALSLLHSTVpegsRGRRIAVLG 382
Cdd:PRK00139 307 L--QGVPGRMERVDAGQGPLVIVD--YAHTPDALEKVLEALRPHA----KGRLICVFG 356
|
|
| PRK11929 |
PRK11929 |
bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE ... |
30-382 |
1.49e-28 |
|
bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE/UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase MurF;
Pssm-ID: 237025 [Multi-domain] Cd Length: 958 Bit Score: 119.81 E-value: 1.49e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1442385866 30 AGVTGISIDSRALKPGEAFFAIKGEQFDGHDFATAAMAAGAGLLVVAEHRLPAFGNTKVPMIVVEDVLEALIRL--GIAA 107
Cdd:PRK11929 27 AATADLRLDSREVQPGDLFVACRGAASDGRAFIDQALARGAAAVLVEAEGEDQVAAADALVLPVADLRKALGELaaRWYG 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1442385866 108 RARSKAQIIAVTGSVGKTTTKEALRHVLSDVGKVHASAASFNNHW-----GVPLT----------LARMPAD-VDYGVFE 171
Cdd:PRK11929 107 RPSEQLSLVAVTGTNGKTSCAQLLAQLLTRLGKPCGSIGTLGARLdgrliPGSLTtpdaiilhriLARMRAAgADAVAME 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1442385866 172 IgmNHHGEIRPLVKMVRPHVALITLIAPAHLGHFANLEEIAVAKAEIFEGIVPGGYALLNRDDKRFRQLqeLAEKAGVEH 251
Cdd:PRK11929 187 A--SSHGLEQGRLDGLRIAVAGFTNLTRDHLDYHGTMQDYEEAKAALFSKLPGLGAAVINADDPAAARL--LAALPRGLK 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1442385866 252 IATFGENARADYRLRDVKLHPTCSCMTVKIGTHEAAVKVGIPGRHVVQNMLAVLGAAHLVGADIAKVMMAMATLSAQGGR 331
Cdd:PRK11929 263 VGYSPQNAGADVQARDLRATAHGQVFTLATPDGSYQLVTRLLGRFNVSNLLLVAAALKKLGLPLAQIARALAAVSPVPGR 342
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 1442385866 332 GARhVLQHPEGAFTLIDESYNANPTSMRAALSLLHStVPEGSRGRRIAVLG 382
Cdd:PRK11929 343 MER-VGPTAGAQGPLVVVDYAHTPDALAKALTALRP-VAQARNGRLVCVFG 391
|
|
| MurC |
COG0773 |
UDP-N-acetylmuramate-alanine ligase MurC and related ligases, MurC/Mpl family [Cell wall ... |
116-455 |
2.15e-22 |
|
UDP-N-acetylmuramate-alanine ligase MurC and related ligases, MurC/Mpl family [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramate-alanine ligase MurC and related ligases, MurC/Mpl family is part of the Pathway/BioSystem: Mureine biosynthesis
Pssm-ID: 440536 [Multi-domain] Cd Length: 451 Bit Score: 99.37 E-value: 2.15e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1442385866 116 IAVTGSVGKTTTKEALRHVLSDVGKvhasaasfnnhwgvpltlarmpaDVDY---GVFEI--GMNHHGEIRPLVkmV--- 187
Cdd:COG0773 107 IAVAGTHGKTTTTSMLAHILEEAGL-----------------------DPTFligGILNNfgTNARLGDGDYFV--Aead 161
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1442385866 188 ---------RPHVALITLIAPAHLGHFANLEEIAVAKAEIFEGIVPGGYALLNRDDKRfrqLQELAEKAGVEHIaTFGEN 258
Cdd:COG0773 162 esdgsflhySPDIAVVTNIEADHLDIYGDLEAIKEAFHEFARNVPFYGLLVLCADDPG---LRELLPRCGRPVI-TYGFS 237
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1442385866 259 ARADYRLRDVKLHPTCSCMTVKI-GTHEAAVKVGIPGRHVVQNMLAVLGAAHLVGADIAKVMMAMATLsaqggRGAR--- 334
Cdd:COG0773 238 EDADYRAENIRIDGGGSTFDVLRrGEELGEVELNLPGRHNVLNALAAIAVALELGVDPEAIAEALASF-----KGVKrrf 312
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1442385866 335 HVLQHPEGaFTLIDEsYNANPTSMRAALSLLHSTVPEgsrGRRIAVL--------GDMV-EFGrQSCKLhADL------- 398
Cdd:COG0773 313 ELKGEVGG-VTVIDD-YAHHPTEIAATLAAAREKYPD---RRLVAVFqphrysrtRDFLdEFA-EALSL-ADEvilldiy 385
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1442385866 399 -AR--PIVDAEVNTLFiggsemsvlkNALPVE-IQTEYRQSTDELLPLVVKAVRPGDVVMV 455
Cdd:COG0773 386 aARekPIPGVSSEDLA----------EAIRKRgKDVVYVPDLDELVEALAEIARPGDVVLT 436
|
|
| murE |
TIGR01085 |
UDP-N-acetylmuramyl-tripeptide synthetase; Most members of this family are EC 6.3.2.13, ... |
32-382 |
5.49e-22 |
|
UDP-N-acetylmuramyl-tripeptide synthetase; Most members of this family are EC 6.3.2.13, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase. An exception is Staphylococcus aureus, in which diaminopimelate is replaced by lysine in the peptidoglycan and MurE is EC 6.3.2.7. The Mycobacteria, part of the closest neighboring branch outside of the low-GC Gram-positive bacteria, use diaminopimelate. A close homolog, scoring just below the trusted cutoff, is found (with introns) in Arabidopsis thaliana. Its role is unknown. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 273435 [Multi-domain] Cd Length: 464 Bit Score: 98.16 E-value: 5.49e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1442385866 32 VTGISIDSRALKPGEAFFAIKGEQFDGHDFATAAMAAGAGLLVVAEHRLPAFGNtkVPMIVVEDVLEALirLGIAAR--- 108
Cdd:TIGR01085 4 VTGLTLDSREVKPGDLFVAIKGTHVDGHDFIHDAIANGAVAVVVERDVDFYVAP--VPVIIVPDLRHAL--SSLAAAfyg 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1442385866 109 -ARSKAQIIAVTGSVGKTTTKEALRHVLSDVGKVHASAASFNNHWG------------------VPLTLARMPAD-VDYG 168
Cdd:TIGR01085 80 hPSKKLKVIGVTGTNGKTTTTSLIAQLLRLLGKKTGLIGTIGYRLGgndliknpaalttpealtLQSTLAEMVEAgAQYA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1442385866 169 VFEIgmNHHGEIRPLVKMVRPHVALITLIAPAHLGHFANLEEIAVAKAEIFEGIVPGGYALLNRDDKRFRQLQELAEKA- 247
Cdd:TIGR01085 160 VMEV--SSHALAQGRVRGVRFDAAVFTNLSRDHLDFHGTMENYFAAKASLFTELGLKRFAVINLDDEYGAQFVKRLPKDi 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1442385866 248 GVEHIATFGENARADYRLRDVKLHPTCSCMTVKIGTHEAAVKVGIPGRHVVQNMLA-VLGAAHLVGADIAKVMMAMATLS 326
Cdd:TIGR01085 238 TVSAITQPADGRAQDIKITDSGYSFEGQQFTFETPAGEGHLHTPLIGRFNVYNLLAaLATLLHLGGIDLEDIVAALEKFR 317
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 1442385866 327 AQGGRgaRHVLQHPEGAFTLIDesYNANPTSMRAALsllhSTVPEGSRGRRIAVLG 382
Cdd:TIGR01085 318 GVPGR--MELVDGGQKFLVIVD--YAHTPDALEKAL----RTLRKHKDGRLIVVFG 365
|
|
| MurD |
COG0771 |
UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell wall/membrane/envelope biogenesis]; ... |
96-318 |
3.80e-21 |
|
UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramoylalanine-D-glutamate ligase is part of the Pathway/BioSystem: Mureine biosynthesis
Pssm-ID: 440534 [Multi-domain] Cd Length: 445 Bit Score: 95.53 E-value: 3.80e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1442385866 96 VLEALIRLGI--------AARArSKAQIIAVTGSVGKTTTKEALRHVLSDVGKvhasaasfnNHW-----GVP-LTLARM 161
Cdd:COG0771 81 LLKAARAAGIpvigeielAYRL-SPAPIIAITGTNGKTTTTTLIGHILKAAGL---------RVAvggniGTPlLDLLLE 150
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1442385866 162 PADVDYGVFEI------GMNHhgeirplvkmVRPHVALITLIAPAHLGHFANLEEIAVAKAEIFEGIVPGGYALLNRDDK 235
Cdd:COG0771 151 PEPPDVYVLELssfqleTTPS----------LRPDVAVILNITPDHLDRHGSMEAYAAAKARIFANQTPDDYAVLNADDP 220
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1442385866 236 RfrqLQELAEKAGVEHIaTFG--ENARADYRLRDVKLHptcscmtVKIGTHE--AAVKVGIPGRHVVQNMLAVLGAAHLV 311
Cdd:COG0771 221 L---TRALAEEAKARVV-PFSlkEPLEGGAGLEDGKLV-------DRASGEEllPVDDLRLPGRHNLENALAALAAARAL 289
|
....*..
gi 1442385866 312 GADIAKV 318
Cdd:COG0771 290 GVPPEAI 296
|
|
| murD |
TIGR01087 |
UDP-N-acetylmuramoylalanine--D-glutamate ligase; [Cell envelope, Biosynthesis and degradation ... |
111-363 |
7.49e-17 |
|
UDP-N-acetylmuramoylalanine--D-glutamate ligase; [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 273436 [Multi-domain] Cd Length: 433 Bit Score: 82.39 E-value: 7.49e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1442385866 111 SKAQIIAVTGSVGKTTTKEALRHVLSDVGKVHASAASFnnhwGVPLTLARMPADVDYGVFEI----GMNHHGeirplvkm 186
Cdd:TIGR01087 100 VPLPVVAITGTNGKTTTTSLLYHLLKAAGLKAFLGGNI----GTPALEVLDQEGAELYVLELssfqLETTES-------- 167
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1442385866 187 VRPHVALITLIAPAHLGHFANLEEIAVAKAEIFEGIVPGGYALLNRDDKRFRQLQelaEKAGVEHIATFGENArADYRLR 266
Cdd:TIGR01087 168 LRPEIALILNISEDHLDWHGSFEDYVAAKLKIFARQTEGDVAVLNADDPRFARLA---QKSKAQVIWFSVEKD-AERGLC 243
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1442385866 267 DVklhptcscmTVKIGTHEAAVKVGIPGRHVVQNMLAVLGAAHLVGADIAKVMMAMATLsaqggRGARHVLQ--HPEGAF 344
Cdd:TIGR01087 244 IR---------DGGLYLKPNDLEGSLLGLHNAENILAAIALAKSLGLNLEAILEALRSF-----KGLPHRLEyvGQKNGV 309
|
250
....*....|....*....
gi 1442385866 345 TLIDESYNANPTSMRAALS 363
Cdd:TIGR01087 310 HFYNDSKATNVHATLAALS 328
|
|
| murD |
PRK14106 |
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional |
111-319 |
9.21e-14 |
|
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional
Pssm-ID: 184511 [Multi-domain] Cd Length: 450 Bit Score: 73.08 E-value: 9.21e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1442385866 111 SKAQIIAVTGSVGKTTTKEALRHVLSDVGKVHASAASFnnhwGVPLTLARMPADVDyGVFEIgmnhhgEIRP----LVKM 186
Cdd:PRK14106 106 SKAPIVAITGTNGKTTTTTLLGEIFKNAGRKTLVAGNI----GYPLIDAVEEYGED-DIIVA------EVSSfqleTIKE 174
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1442385866 187 VRPHVALITLIAPAHLGHFANLEEIAVAKAEIFEGIVPGGYALLNRDDKRFRQL--------------QELAEKAGVEH- 251
Cdd:PRK14106 175 FKPKVGCILNITPDHLDRHKTMENYIKAKARIFENQRPSDYTVLNYDDPRTRSLakkakarviffsrkSLLEEGVFVKNg 254
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1442385866 252 --IATFGENARADYRLRDVKlhptcscmtvkigtheaavkvgIPGRHVVQNMLAVLGAAHLVGAD---IAKVM 319
Cdd:PRK14106 255 kiVISLGGKEEEVIDIDEIF----------------------IPGEHNLENALAATAAAYLLGISpdvIANTL 305
|
|
| PRK14016 |
PRK14016 |
cyanophycin synthetase; Provisional |
115-324 |
1.07e-08 |
|
cyanophycin synthetase; Provisional
Pssm-ID: 237586 [Multi-domain] Cd Length: 727 Bit Score: 57.47 E-value: 1.07e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1442385866 115 IIAVTGSVGKTTTKEALRHVLSDVGKVHASAAS----FNNHwgvpLTL---------ARM----PaDVDYGVFEIGmnHH 177
Cdd:PRK14016 482 IVAVTGTNGKTTTTRLIAHILKLSGKRVGMTTTdgvyIDGR----LIDkgdctgpksARRvlmnP-DVEAAVLETA--RG 554
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1442385866 178 GEIRPLVKMVRPHVALITLIAPAHLGHFA--NLEEIAVAKAEIFEGIVPGGYALLNRDDKRFRQLQELAeKAGV------ 249
Cdd:PRK14016 555 GILREGLAYDRCDVGVVTNIGEDHLGLGGinTLEDLAKVKRVVVEAVKPDGYAVLNADDPMVAAMAERC-KGKViffsmd 633
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1442385866 250 -------EHIAtfgENARADYRLRDVklhptcscMTVKIGTHE------AAVKVGIPGR--HVVQNMLAVLGAAHLVGAD 314
Cdd:PRK14016 634 pdnpviaEHRA---QGGRAVYVEGDY--------IVLAEGGWEiriislADIPLTLGGKagFNIENALAAIAAAWALGID 702
|
250
....*....|
gi 1442385866 315 IAKVMMAMAT 324
Cdd:PRK14016 703 IELIRAGLRT 712
|
|
| Mur_ligase |
pfam01225 |
Mur ligase family, catalytic domain; This family contains a number of related ligase enzymes ... |
32-103 |
4.27e-07 |
|
Mur ligase family, catalytic domain; This family contains a number of related ligase enzymes which have EC numbers 6.3.2.*. This family includes: MurC, MurD, MurE, MurF, Mpl and FolC. MurC, MurD, Mure and MurF catalyze consecutive steps in the synthesis of peptidoglycan. Peptidoglycan consists of a sheet of two sugar derivatives, with one of these N-acetylmuramic acid attaching to a small pentapeptide. The pentapeptide is is made of L-alanine, D-glutamic acid, Meso-diaminopimelic acid and D-alanyl alanine. The peptide moiety is synthesized by successively adding these amino acids to UDP-N-acetylmuramic acid. MurC transfers the L-alanine, MurD transfers the D-glutamate, MurE transfers the diaminopimelic acid, and MurF transfers the D-alanyl alanine. This family also includes Folylpolyglutamate synthase that transfers glutamate to folylpolyglutamate.
Pssm-ID: 460121 [Multi-domain] Cd Length: 84 Bit Score: 47.61 E-value: 4.27e-07
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1442385866 32 VTGISIDSRALKPGEAFFAIKGEQFDGHDFATAAMAAGAGLLVV--AEHRL----PAFGNTKVPMIVVEDVLEALIRL 103
Cdd:pfam01225 2 IHFVGIDGRGMSPGALFLALKGYRVDGSDFIESLIALGAAAVVGhdAANNIspdnPELEAAKVPGIPVIDRREALAEL 79
|
|
| F430_CfbE |
NF033197 |
coenzyme F430 synthase; Members of this family are coenzyme F430 synthase, involving in ... |
115-361 |
1.27e-06 |
|
coenzyme F430 synthase; Members of this family are coenzyme F430 synthase, involving in synthesizing coenzyme F430, which is used in methanogens by coenzyme M reductase. Members of this family are restricted to archaeal methanogens, and resemble (and may be misannotated as) MurD, an enzyme of bacterial cell wall biosynthesis.
Pssm-ID: 467992 [Multi-domain] Cd Length: 419 Bit Score: 50.40 E-value: 1.27e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1442385866 115 IIAVTGSVGKTTTKEALRHVLSDVGKV-HASAASFNNHWGV--------P---LTLAR-----MPADVDYGVFEIGmnhh 177
Cdd:NF033197 94 FIEITGVKGKTTTAELLAHILSDEYVLlHTSRGTERYPEGElsnkgsitPasiLNALElaeeiGIDDYGFLIFEVS---- 169
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1442385866 178 geirpLVKMVRPHVALITliapahlghfaNLEE---IA-------VAKAEIFEGIVPGGYALLNRDDKRFRQLQELAEKA 247
Cdd:NF033197 170 -----LGGTGAGDVGIIT-----------NILEdypIAggkrsasAAKLQSLKNAKVGSINVADLGIYINGKNKLVITVA 233
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1442385866 248 GVEhIATFgenaradYRLRDVKlhptcscmtvkiGTHEAAVKVGIPGRHVVQNMLAVLGAAHLVGADIAKVMMAMATLSA 327
Cdd:NF033197 234 GVE-ILSK-------YPLRFKY------------GNTEFEFNPLLFGPHYRENSLFAIEAALNLGVDPEDIISALKGFKG 293
|
250 260 270
....*....|....*....|....*....|....*
gi 1442385866 328 QGGRGARHVlqhpEGAFTLIDesyNANP-TSMRAA 361
Cdd:NF033197 294 LPGRMAVKK----EGGVVIVD---NINPgLNVKAI 321
|
|
| PRK14022 |
PRK14022 |
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L-lysine ligase; |
32-399 |
2.41e-06 |
|
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L-lysine ligase;
Pssm-ID: 237588 [Multi-domain] Cd Length: 481 Bit Score: 50.04 E-value: 2.41e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1442385866 32 VTGISIDSRALKPGEAFFAiKGEQFDgHDFATAAMAAGAGlLVVAEHRLPAfgntKVPMIVVEDVLEA--LIRLGIAARA 109
Cdd:PRK14022 34 FDDISYDSRTADEGTLFFA-KGAYFK-HKFLQNAITQGLK-LYVSEKDYEV----GIPQVIVPDIKKAmsLIAMEFYDNP 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1442385866 110 RSKAQIIAVTGSVGKTTTKEALRHVLSDVGKvhASAAS-----------FNNHWGVP--LTLARMPAD-VDYGVFEIGM- 174
Cdd:PRK14022 107 QHKLKLLAFTGTKGKTTAAYFAYHILKQLHK--PAMLStmnttldgetfFKSALTTPesLDLFKMMAEaVDNGMTHLIMe 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1442385866 175 -NHHGEIRPLVKMVRPHVALITLIAPAHLG---HfANLEEIAVAKAEIFEGivpGGYALLNRDDKRFrqlQELAEKAGVE 250
Cdd:PRK14022 185 vSSQAYLVGRVYGLTFDVGVFLNITPDHIGpieH-PTFEDYFYHKRLLMEN---SKAVVVNSDMDHF---SELLEQVTPQ 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1442385866 251 HIATFGENARADYRLRdvklHPTCSCMTVKIGTHeaaVKVGIPGRHVVQNMLAVLGAAHLVGADIAKVMMAMATLSAQGg 330
Cdd:PRK14022 258 EHDFYGIDSENQIMAS----NAFSFEATGKLAGT---YDIQLIGKFNQENAMAAGLACLRLGASLEDIQKGIAQTPVPG- 329
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1442385866 331 rgaR-HVLQHPEGAFTLIDesYNANPTSMRAALSLlhstVPEGSRGRRIAVLG--------DMVEFGRQSCKlHADLA 399
Cdd:PRK14022 330 ---RmEVLTQSNGAKVFID--YAHNGDSLNKLIDV----VEEHQKGKLILLLGaagnkgesRRPDFGRVANR-HPYLQ 397
|
|
| Mur_ligase_C |
pfam02875 |
Mur ligase family, glutamate ligase domain; This family contains a number of related ligase ... |
342-400 |
6.15e-04 |
|
Mur ligase family, glutamate ligase domain; This family contains a number of related ligase enzymes which have EC numbers 6.3.2.*. This family includes: MurC, MurD, MurE, MurF, Mpl and FolC. MurC, MurD, Mure and MurF catalyze consecutive steps in the synthesis of peptidoglycan. Peptidoglycan consists of a sheet of two sugar derivatives, with one of these N-acetylmuramic acid attaching to a small pentapeptide. The pentapeptide is is made of L-alanine, D-glutamic acid, Meso-diaminopimelic acid and D-alanyl alanine. The peptide moiety is synthesized by successively adding these amino acids to UDP-N-acetylmuramic acid. MurC transfers the L-alanine, MurD transfers the D-glutamate, MurE transfers the diaminopimelic acid, and MurF transfers the D-alanyl alanine. This family also includes Folylpolyglutamate synthase that transfers glutamate to folylpolyglutamate.
Pssm-ID: 460731 [Multi-domain] Cd Length: 87 Bit Score: 38.86 E-value: 6.15e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*....
gi 1442385866 342 GAFTLIDEsYNANPTSMRAALSLLHSTVPegsrGRRIAVLGDMVEFGRQsckLHADLAR 400
Cdd:pfam02875 12 NGVLVIDD-YAHNPDAMEAALRALRNLFP----GRLILVFGGMGDRDAE---FHALLGR 62
|
|
| |
