BREX system Lon protease-like protein BrxL is part of the phage resistance system BREX (BacteRiophage EXclusion) that employs a defense strategy involving DNA methylation of the host cell and blocking phage DNA replication
Phospholipase D-like domain at C-terminus of MIT; MIT_C is the C-terminal domain of ...
564-702
2.97e-53
Phospholipase D-like domain at C-terminus of MIT; MIT_C is the C-terminal domain of MIT-containing proteins, pfam04212. It contains an unanticipated phospholipase d fold (PLD fold) that binds avidly to phosphoinositide-containing membranes. It is conserved in eukaryotes, though not fungi and plants, and some bacteria.
:
Pssm-ID: 465180 Cd Length: 137 Bit Score: 180.03 E-value: 2.97e-53
TIGR02688 family protein; Members of this family are uncharacterized proteins sporadically ...
36-484
0e+00
TIGR02688 family protein; Members of this family are uncharacterized proteins sporadically distributed in bacteria and archaea, about 470 amino acids in length. Several members of this family appear in public databases with annotation as ATP-dependent protease La, despite the lack of similarity to families TIGR00763 (ATP-dependent protease La) or pfam02190 (ATP-dependent protease La (LON) domain). This protein is repeatedly found downstream of another uncharacterized protein of about 880 amino acids in length, described by model TIGR02687. [Hypothetical proteins, Conserved]
Pssm-ID: 131735 [Multi-domain] Cd Length: 449 Bit Score: 657.17 E-value: 0e+00
Lon-like protease BrxL-like, ATPase domain; This entry represents the ATPase domain found in ...
180-492
1.29e-178
Lon-like protease BrxL-like, ATPase domain; This entry represents the ATPase domain found in BREX system Lon protease-like protein BrxL from Bacillus cereus and similar proteins. BrxL is part of a type 1 BREX system which contains a C-terminal Lon-like protease domain (pfam05362. BREX systems (bacteriophage exclusion) provide immunity against bacteriophage, a system that allows phage adsorption but prevents phage DNA replication, without degradation of the phage DNA. Methylation of bacterial DNA by PglX probably guides self/non-self discrimination. This entry also includes a few uncharacterized viral sequences.
Pssm-ID: 463848 Cd Length: 313 Bit Score: 511.67 E-value: 1.29e-178
Phospholipase D-like domain at C-terminus of MIT; MIT_C is the C-terminal domain of ...
564-702
2.97e-53
Phospholipase D-like domain at C-terminus of MIT; MIT_C is the C-terminal domain of MIT-containing proteins, pfam04212. It contains an unanticipated phospholipase d fold (PLD fold) that binds avidly to phosphoinositide-containing membranes. It is conserved in eukaryotes, though not fungi and plants, and some bacteria.
Pssm-ID: 465180 Cd Length: 137 Bit Score: 180.03 E-value: 2.97e-53
MIT_C; domain found C-terminal to MIT (contained within Microtubule Interacting and ...
561-709
2.82e-43
MIT_C; domain found C-terminal to MIT (contained within Microtubule Interacting and Trafficking molecules) domains, as well as in some bacterial proteins. The function of this domain is unknown.
Pssm-ID: 239148 Cd Length: 148 Bit Score: 152.78 E-value: 2.82e-43
IS21-like element helper ATPase IstB; This protein family model resembles PF01695, but was ...
228-260
3.37e-03
IS21-like element helper ATPase IstB; This protein family model resembles PF01695, but was built to hit full-length AAA+ ATPases of IS21 family IS (insertion sequence) elements.
Pssm-ID: 439516 Cd Length: 232 Bit Score: 39.76 E-value: 3.37e-03
TIGR02688 family protein; Members of this family are uncharacterized proteins sporadically ...
36-484
0e+00
TIGR02688 family protein; Members of this family are uncharacterized proteins sporadically distributed in bacteria and archaea, about 470 amino acids in length. Several members of this family appear in public databases with annotation as ATP-dependent protease La, despite the lack of similarity to families TIGR00763 (ATP-dependent protease La) or pfam02190 (ATP-dependent protease La (LON) domain). This protein is repeatedly found downstream of another uncharacterized protein of about 880 amino acids in length, described by model TIGR02687. [Hypothetical proteins, Conserved]
Pssm-ID: 131735 [Multi-domain] Cd Length: 449 Bit Score: 657.17 E-value: 0e+00
conserved hypothetical protein; This model describes a protein family of unknown function, ...
32-495
0e+00
conserved hypothetical protein; This model describes a protein family of unknown function, about 690 residues in length, in which some members show C-terminal sequence similarity to pfam05362, which is the Lon protease C-terminal proteolytic domain, from MEROPS family S16. However, the annotated catalytic sites of E. coli Lon protease are not conserved in members of this family. Members have a motif GP[RK][GS]TGKS, similar to the ATP-binding P-loop motif GxxGxGK[ST]. [Hypothetical proteins, Conserved]
Pssm-ID: 131701 [Multi-domain] Cd Length: 675 Bit Score: 577.57 E-value: 0e+00
Lon-like protease BrxL-like, ATPase domain; This entry represents the ATPase domain found in ...
180-492
1.29e-178
Lon-like protease BrxL-like, ATPase domain; This entry represents the ATPase domain found in BREX system Lon protease-like protein BrxL from Bacillus cereus and similar proteins. BrxL is part of a type 1 BREX system which contains a C-terminal Lon-like protease domain (pfam05362. BREX systems (bacteriophage exclusion) provide immunity against bacteriophage, a system that allows phage adsorption but prevents phage DNA replication, without degradation of the phage DNA. Methylation of bacterial DNA by PglX probably guides self/non-self discrimination. This entry also includes a few uncharacterized viral sequences.
Pssm-ID: 463848 Cd Length: 313 Bit Score: 511.67 E-value: 1.29e-178
BREX system Lon protease-like protein BrxL N-terminal; This entry represents the N-terminal ...
38-169
6.73e-63
BREX system Lon protease-like protein BrxL N-terminal; This entry represents the N-terminal domain of BREX system Lon protease-like protein BrxL from Bacillus cereus and similar proteins. BrxL is part of a type 1 BREX system, which contains a C-terminal Lon-like protease domain (pfam05362). BREX systems (bacteriophage exclusion) provide immunity against bacteriophage, a system that allows phage adsorption but prevents phage DNA replication, without degradation of the phage DNA.
Pssm-ID: 466591 [Multi-domain] Cd Length: 132 Bit Score: 205.47 E-value: 6.73e-63
Phospholipase D-like domain at C-terminus of MIT; MIT_C is the C-terminal domain of ...
564-702
2.97e-53
Phospholipase D-like domain at C-terminus of MIT; MIT_C is the C-terminal domain of MIT-containing proteins, pfam04212. It contains an unanticipated phospholipase d fold (PLD fold) that binds avidly to phosphoinositide-containing membranes. It is conserved in eukaryotes, though not fungi and plants, and some bacteria.
Pssm-ID: 465180 Cd Length: 137 Bit Score: 180.03 E-value: 2.97e-53
MIT_C; domain found C-terminal to MIT (contained within Microtubule Interacting and ...
561-709
2.82e-43
MIT_C; domain found C-terminal to MIT (contained within Microtubule Interacting and Trafficking molecules) domains, as well as in some bacterial proteins. The function of this domain is unknown.
Pssm-ID: 239148 Cd Length: 148 Bit Score: 152.78 E-value: 2.82e-43
IS21-like element helper ATPase IstB; This protein family model resembles PF01695, but was ...
228-260
3.37e-03
IS21-like element helper ATPase IstB; This protein family model resembles PF01695, but was built to hit full-length AAA+ ATPases of IS21 family IS (insertion sequence) elements.
Pssm-ID: 439516 Cd Length: 232 Bit Score: 39.76 E-value: 3.37e-03
Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
References:
Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
of the residues that compose this conserved feature have been mapped to the query sequence.
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The thumbnail image, if present, provides an approximate view of the feature's location in 3 dimensions.
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Functional characterization of the conserved domain architecture found on the query.
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This image shows a graphical summary of conserved domains identified on the query sequence.
The Show Concise/Full Display button at the top of the page can be used to select the desired level of detail: only top scoring hits
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Domains are color coded according to superfamilies
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if a domain or superfamily has been annotated with functional sites (conserved features),
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click on the bars or triangles to view your query sequence embedded in a multiple sequence alignment of the proteins used to develop the corresponding domain model.
The table lists conserved domains identified on the query sequence. Click on the plus sign (+) on the left to display full descriptions, alignments, and scores.
Click on the domain model's accession number to view the multiple sequence alignment of the proteins used to develop the corresponding domain model.
To view your query sequence embedded in that multiple sequence alignment, click on the colored bars in the Graphical Summary portion of the search results page,
or click on the triangles, if present, that represent functional sites (conserved features)
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Concise Display shows only the best scoring domain model, in each hit category listed below except non-specific hits, for each region on the query sequence.
(labeled illustration) Standard Display shows only the best scoring domain model from each source, in each hit category listed below for each region on the query sequence.
(labeled illustration) Full Display shows all domain models, in each hit category below, that meet or exceed the RPS-BLAST threshold for statistical significance.
(labeled illustration) Four types of hits can be shown, as available,
for each region on the query sequence:
specific hits meet or exceed a domain-specific e-value threshold
(illustrated example)
and represent a very high confidence that the query sequence belongs to the same protein family as the sequences use to create the domain model
non-specific hits
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the domain superfamily to which the specific and non-specific hits belong
multi-domain models that were computationally detected and are likely to contain multiple single domains
Retrieve proteins that contain one or more of the domains present in the query sequence, using the Conserved Domain Architecture Retrieval Tool
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