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Conserved domains on  [gi|1444742699|ref|WP_115528848|]
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MULTISPECIES: AraC family transcriptional regulator [Xanthomonas]

Protein Classification

helix-turn-helix domain-containing protein( domain architecture ID 11454391)

helix-turn-helix (HTH) domain-containing protein with an AraC family HTH domain, binds DNA and may function as a transcriptional regulator

CATH:  1.10.10.60
Gene Ontology:  GO:0003700|GO:0003677
PubMed:  10473770|15808743|8831795

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AraC COG2207
AraC-type DNA-binding domain and AraC-containing proteins [Transcription];
140-274 4.55e-17

AraC-type DNA-binding domain and AraC-containing proteins [Transcription];


:

Pssm-ID: 441809 [Multi-domain]  Cd Length: 258  Bit Score: 79.05  E-value: 4.55e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1444742699 140 RPLLLHLAAMQRDFVEQEQRCPGRSRSRRRQVFGRMQRARLYLEGNSDRVVRISELAQLTNFSSWYVSKTFQSLYEESPQ 219
Cdd:COG2207   119 LLLLLLLLLLALLRALELLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLTLEELARELGLSPRTLSRLFKEETGTSPK 198

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1444742699 220 ALSARLRLERASDLLRDTSMMIGEVAAASGFDNCCSFARAFRARFGVSASRYREQ 274
Cdd:COG2207   199 QYLRELRLERAKRLLAETDLSISEIAYELGFSSQSHFSRAFKKRFGVTPSEYRKR 253
 
Name Accession Description Interval E-value
AraC COG2207
AraC-type DNA-binding domain and AraC-containing proteins [Transcription];
140-274 4.55e-17

AraC-type DNA-binding domain and AraC-containing proteins [Transcription];


Pssm-ID: 441809 [Multi-domain]  Cd Length: 258  Bit Score: 79.05  E-value: 4.55e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1444742699 140 RPLLLHLAAMQRDFVEQEQRCPGRSRSRRRQVFGRMQRARLYLEGNSDRVVRISELAQLTNFSSWYVSKTFQSLYEESPQ 219
Cdd:COG2207   119 LLLLLLLLLLALLRALELLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLTLEELARELGLSPRTLSRLFKEETGTSPK 198

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1444742699 220 ALSARLRLERASDLLRDTSMMIGEVAAASGFDNCCSFARAFRARFGVSASRYREQ 274
Cdd:COG2207   199 QYLRELRLERAKRLLAETDLSISEIAYELGFSSQSHFSRAFKKRFGVTPSEYRKR 253
HTH_ARAC smart00342
helix_turn_helix, arabinose operon control protein;
190-272 3.02e-16

helix_turn_helix, arabinose operon control protein;


Pssm-ID: 197666 [Multi-domain]  Cd Length: 84  Bit Score: 72.20  E-value: 3.02e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1444742699  190 VRISELAQLTNFSSWYVSKTFQSLYEESPQALSARLRLERASDLLRDTSMMIGEVAAASGFDNCCSFARAFRARFGVSAS 269
Cdd:smart00342   2 LTLEDLAEALGVSPRHLQRLFKKETGTTPKQYLRDRRLERARRLLRDTDLSVTEIALRVGFSSQSYFSRAFKKLFGVTPS 81


                   ...
gi 1444742699  270 RYR 272
Cdd:smart00342  82 EYR 84
HTH_18 pfam12833
Helix-turn-helix domain;
195-274 8.30e-16

Helix-turn-helix domain;


Pssm-ID: 432818 [Multi-domain]  Cd Length: 81  Bit Score: 71.08  E-value: 8.30e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1444742699 195 LAQLTNFSSWYVSKTFQSLYEESPQALSARLRLERA-SDLLRDTSMMIGEVAAASGFDNCCSFARAFRARFGVSASRYRE 273
Cdd:pfam12833   1 LAAALGMSPRTLSRLFKRELGLSPKEYLRRLRLERArRLLLEDTGLSVAEIALALGFSDASHFSRAFRRLFGLTPSEYRR 80


                  .
gi 1444742699 274 Q 274
Cdd:pfam12833  81 R 81
ftrA PRK09393
transcriptional activator FtrA; Provisional
 135-274 1.92e-09

transcriptional activator FtrA; Provisional


Pssm-ID: 181818 [Multi-domain]  Cd Length: 322  Bit Score: 57.67  E-value: 1.92e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1444742699 135 GSASARPLLLHLaaMQRDF------------VEQEQR-----------CPGRSRSRRRQVFGRMqRARLYLEGNsdrvvr 191
Cdd:PRK09393  166 GSAAGIDLCLHL--VRRDFgseaanrvarrlVVPPHRdggqaqfvprpVASRESDRLGPLIDWM-RAHLAEPHT------ 236

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1444742699 192 ISELAQLTNFSSwyvsKTFQSLYEE----SPQALSARLRLERASDLLRDTSMMIGEVAAASGFDNCCSFARAFRARFGVS 267
Cdd:PRK09393  237 VASLAARAAMSP----RTFLRRFEAatgmTPAEWLLRERLARARDLLESSALSIDQIAERAGFGSEESLRHHFRRRAATS 312


                  ....*..
gi 1444742699 268 ASRYREQ 274
Cdd:PRK09393  313 PAAYRKR 319
 
Name Accession Description Interval E-value
AraC COG2207
AraC-type DNA-binding domain and AraC-containing proteins [Transcription];
140-274 4.55e-17

AraC-type DNA-binding domain and AraC-containing proteins [Transcription];


Pssm-ID: 441809 [Multi-domain]  Cd Length: 258  Bit Score: 79.05  E-value: 4.55e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1444742699 140 RPLLLHLAAMQRDFVEQEQRCPGRSRSRRRQVFGRMQRARLYLEGNSDRVVRISELAQLTNFSSWYVSKTFQSLYEESPQ 219
Cdd:COG2207   119 LLLLLLLLLLALLRALELLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLTLEELARELGLSPRTLSRLFKEETGTSPK 198

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1444742699 220 ALSARLRLERASDLLRDTSMMIGEVAAASGFDNCCSFARAFRARFGVSASRYREQ 274
Cdd:COG2207   199 QYLRELRLERAKRLLAETDLSISEIAYELGFSSQSHFSRAFKKRFGVTPSEYRKR 253
HTH_ARAC smart00342
helix_turn_helix, arabinose operon control protein;
190-272 3.02e-16

helix_turn_helix, arabinose operon control protein;


Pssm-ID: 197666 [Multi-domain]  Cd Length: 84  Bit Score: 72.20  E-value: 3.02e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1444742699  190 VRISELAQLTNFSSWYVSKTFQSLYEESPQALSARLRLERASDLLRDTSMMIGEVAAASGFDNCCSFARAFRARFGVSAS 269
Cdd:smart00342   2 LTLEDLAEALGVSPRHLQRLFKKETGTTPKQYLRDRRLERARRLLRDTDLSVTEIALRVGFSSQSYFSRAFKKLFGVTPS 81


                   ...
gi 1444742699  270 RYR 272
Cdd:smart00342  82 EYR 84
HTH_18 pfam12833
Helix-turn-helix domain;
195-274 8.30e-16

Helix-turn-helix domain;


Pssm-ID: 432818 [Multi-domain]  Cd Length: 81  Bit Score: 71.08  E-value: 8.30e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1444742699 195 LAQLTNFSSWYVSKTFQSLYEESPQALSARLRLERA-SDLLRDTSMMIGEVAAASGFDNCCSFARAFRARFGVSASRYRE 273
Cdd:pfam12833   1 LAAALGMSPRTLSRLFKRELGLSPKEYLRRLRLERArRLLLEDTGLSVAEIALALGFSDASHFSRAFRRLFGLTPSEYRR 80


                  .
gi 1444742699 274 Q 274
Cdd:pfam12833  81 R 81
GlxA COG4977
Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH ...
 134-274 7.73e-15

Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH domain [Transcription];


Pssm-ID: 444002 [Multi-domain]  Cd Length: 318  Bit Score: 73.27  E-value: 7.73e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1444742699 134 SGSASARPLLLHL--------AAMQ--RDFVEQEQRCPGRS-RSRRRQVFG----RMQRARLYLEGNSDRVVRISELAQL 198
Cdd:COG4977   156 AGGTAGIDLALHLverdhgaeLANAvaRRLVVDPRRPGGQAqFSPLLVPLGhrdpRLARAQAWMEANLEEPLSVDELARR 235

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1444742699 199 TNFSSwyvsKTFQSLYEE----SPQALSARLRLERASDLLRDTSMMIGEVAAASGFDNCCSFARAFRARFGVSASRYREQ 274
Cdd:COG4977   236 AGMSP----RTLERRFRAatgtTPARYLQRLRLERARRLLETTDLSIEEIAAACGFGSASHFRRAFRRRFGVSPSAYRRR 311
AdaA COG2169
Methylphosphotriester-DNA--protein-cysteine methyltransferase (N-terminal fragment of Ada), ...
 176-274 1.39e-09

Methylphosphotriester-DNA--protein-cysteine methyltransferase (N-terminal fragment of Ada), contains Zn-binding and two AraC-type DNA-binding domains [Replication, recombination and repair];


Pssm-ID: 441772 [Multi-domain]  Cd Length: 358  Bit Score: 58.14  E-value: 1.39e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1444742699 176 QRARLYLEGNSDRVVRISELAQLTNFSSWYVSKTFQSLYEESPQALSARLRLERASDLLrDTSMMIGEVAAASGFDNCCS 255
Cdd:COG2169    87 ARACRLIEAGAEDRPSLEDLAARLGLSPRHLRRLFKAHTGVTPKAYARARRLLRARQLL-QTGLSVTDAAYAAGFGSLSR 165

                          90
                  ....*....|....*....
gi 1444742699 256 FARAFRARFGVSASRYREQ 274
Cdd:COG2169   166 FYEAFKKLLGMTPSAYRRG 184
ftrA PRK09393
transcriptional activator FtrA; Provisional
 135-274 1.92e-09

transcriptional activator FtrA; Provisional


Pssm-ID: 181818 [Multi-domain]  Cd Length: 322  Bit Score: 57.67  E-value: 1.92e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1444742699 135 GSASARPLLLHLaaMQRDF------------VEQEQR-----------CPGRSRSRRRQVFGRMqRARLYLEGNsdrvvr 191
Cdd:PRK09393  166 GSAAGIDLCLHL--VRRDFgseaanrvarrlVVPPHRdggqaqfvprpVASRESDRLGPLIDWM-RAHLAEPHT------ 236

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1444742699 192 ISELAQLTNFSSwyvsKTFQSLYEE----SPQALSARLRLERASDLLRDTSMMIGEVAAASGFDNCCSFARAFRARFGVS 267
Cdd:PRK09393  237 VASLAARAAMSP----RTFLRRFEAatgmTPAEWLLRERLARARDLLESSALSIDQIAERAGFGSEESLRHHFRRRAATS 312


                  ....*..
gi 1444742699 268 ASRYREQ 274
Cdd:PRK09393  313 PAAYRKR 319
PRK10219 PRK10219
superoxide response transcriptional regulator SoxS;
181-274 3.98e-08

superoxide response transcriptional regulator SoxS;


Pssm-ID: 182314 [Multi-domain]  Cd Length: 107  Bit Score: 50.69  E-value: 3.98e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1444742699 181 YLEGNSDRVVRISELAQLTNFSSWYVSKTFQSLYEESPQALSARLRLERASDLLRDTSMMIGEVAAASGFDNCCSFARAF 260
Cdd:PRK10219   13 WIDEHIDQPLNIDVVAKKSGYSKWYLQRMFRTVTHQTLGDYIRQRRLLLAAVELRTTERPIFDIAMDLGYVSQQTFSRVF 92

                          90
                  ....*....|....
gi 1444742699 261 RARFGVSASRYREQ 274
Cdd:PRK10219   93 RRQFDRTPSDYRHR 106
PRK10572 PRK10572
arabinose operon transcriptional regulator AraC;
226-274 4.36e-04

arabinose operon transcriptional regulator AraC;


Pssm-ID: 236717 [Multi-domain]  Cd Length: 290  Bit Score: 41.11  E-value: 4.36e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1444742699 226 RLERASDLLRDTSMMIGEVAAASGFDNCCSFARAFRARFGVSASRYREQ 274
Cdd:PRK10572  236 RISRAKLLLQTTRMPIATIGRNVGYDDQLYFSRVFKKCTGASPSEFRAR 284
PRK13501 PRK13501
HTH-type transcriptional activator RhaR;
224-284 1.02e-03

HTH-type transcriptional activator RhaR;


Pssm-ID: 184092 [Multi-domain]  Cd Length: 290  Bit Score: 39.89  E-value: 1.02e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1444742699 224 RLRLERASDLLRDTSMMIGEVAAASGFDNCCSFARAFRARFGVSASRYR---EQTTNPPDSAKP 284
Cdd:PRK13501  227 QIRLCHAKCLLRGSEHRISDIAARCGFEDSNYFSAVFTREAGMTPRDYRqrfIRSPVLPAKNEP 290
PRK15121 PRK15121
MDR efflux pump AcrAB transcriptional activator RobA;
181-272 2.65e-03

MDR efflux pump AcrAB transcriptional activator RobA;


Pssm-ID: 185076 [Multi-domain]  Cd Length: 289  Bit Score: 38.84  E-value: 2.65e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1444742699 181 YLEGNSDRVVRISELAQLTNFSSWYVSKTFQslyEESPQALSARLR---LERASDLLRDTSMMIGEVAAASGFDNCCSFA 257
Cdd:PRK15121   13 WLEGHLDQPLSLDNVAAKAGYSKWHLQRMFK---DVTGHAIGAYIRarrLSKAAVALRLTSRPILDIALQYRFDSQQTFT 89

                          90
                  ....*....|....*
gi 1444742699 258 RAFRARFGVSASRYR 272
Cdd:PRK15121   90 RAFKKQFAQTPALYR 104
PRK09685 PRK09685
DNA-binding transcriptional activator FeaR; Provisional
 224-274 3.08e-03

DNA-binding transcriptional activator FeaR; Provisional


Pssm-ID: 236612 [Multi-domain]  Cd Length: 302  Bit Score: 38.47  E-value: 3.08e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1444742699 224 RLRLERASDLLRDTSM--MIGEVAAASGFDNCCSFARAFRARFGVSASRYREQ 274
Cdd:PRK09685  248 NRRLDRCADDLRPAADdeKITSIAYKWGFSDSSHFSTAFKQRFGVSPGEYRRK 300
PRK11511 PRK11511
MDR efflux pump AcrAB transcriptional activator MarA;
181-283 3.58e-03

MDR efflux pump AcrAB transcriptional activator MarA;


Pssm-ID: 236920 [Multi-domain]  Cd Length: 127  Bit Score: 37.00  E-value: 3.58e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1444742699 181 YLEGNSDRVVRISELAQLTNFSSWYVSKTFQslyEESPQALSARLRLERASDL---LRDTSMMIGEVAAASGFDNCCSFA 257
Cdd:PRK11511   17 WIEDNLESPLSLEKVSERSGYSKWHLQRMFK---KETGHSLGQYIRSRKMTEIaqkLKESNEPILYLAERYGFESQQTLT 93

                          90       100
                  ....*....|....*....|....*.
gi 1444742699 258 RAFRARFGVSASRYReqTTNPPDSAK 283
Cdd:PRK11511   94 RTFKNYFDVPPHKYR--MTNMQGESR 117
PRK10371 PRK10371
transcriptional regulator MelR;
162-272 4.80e-03

transcriptional regulator MelR;


Pssm-ID: 182416 [Multi-domain]  Cd Length: 302  Bit Score: 37.88  E-value: 4.80e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1444742699 162 GRSRSRRRQVFgrMQRARLYLEGNSDRVVRISELAQLTNFSSWYVSKTFQSLYEESPQALSARLRLERASDLLRDTSMMI 241
Cdd:PRK10371  182 KNSVSRHAQFY--VSQMLGFIAENYDQALTINDVAEHVKLNANYAMGIFQRVMQLTMKQYITAMRINHVRALLSDTDKSI 259

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1444742699 242 GEVAAASGFDNCCSFARAFRARFGVSASRYR 272
Cdd:PRK10371  260 LDIALTAGFRSSSRFYSTFGKYVGMSPQQYR 290
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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