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Conserved domains on  [gi|1444982458|ref|WP_115598370|]
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1-acyl-sn-glycerol-3-phosphate acyltransferase [Corynebacterium amycolatum]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PlsC COG0204
1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; ...
 1-209 4.68e-53

1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; 1-acyl-sn-glycerol-3-phosphate acyltransferase is part of the Pathway/BioSystem: Phospholipid biosynthesis


:

Pssm-ID: 439974 [Multi-domain]  Cd Length: 215  Bit Score: 179.43  E-value: 4.68e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1444982458   1 MFKDPVYLTIIGLARTVFFAQGLKFTVKGWENVPKDSGAVLVTNHTGYMDFTYVGLPFRKHrrfVRFMAKKEVFDHSVAG 80
Cdd:COG0204     7 LLRRFRYRLVRLWARLLLRLLGVRVRVEGLENLPADGPVLIVANHQSWLDILLLLAALPRP---VRFVAKKELFKIPLLG 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1444982458  81 PIMRACKHIPVDRTDGS---KSFEEACAKLENDELVGIFPESTISRSFEVKNLKSGAVRMAQRTGKPIIPVLIVGSQRVW 157
Cdd:COG0204    84 WLLRALGAIPVDRSKRRaalRALRQAVEALKAGESLVIFPEGTRSPDGRLLPFKTGAARLALEAGVPIVPVAIDGTERAL 163

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1444982458 158 TKGHPKHLGRsntpIHITVLPPWTPEG----DPAEATEKLHEIMDQGVRQLWDEYA 209
Cdd:COG0204   164 PKGFLPRPGK----VTVRIGPPIDPSDlegeDRRELAERLRAAIEALLAELRAEAA 215
Tar super family cl43297
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];
247-376 3.30e-04

Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];


The actual alignment was detected with superfamily member COG0840:

Pssm-ID: 440602 [Multi-domain]  Cd Length: 533  Bit Score: 43.47  E-value: 3.30e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1444982458 247 RQRIRHLRGDLAAFKEKLAESAREFGDSAREFGDQTRQQfldASQTmsaesarrrEQTTALLAQFRQSVEQMADDVVAGA 326
Cdd:COG0840   248 IENLRELVGQVRESAEQVASASEELAASAEELAAGAEEQ---AASL---------EETAAAMEELSATVQEVAENAQQAA 315

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1444982458 327 KESKESVRTATDSMRVTfrEAYVQLEKASASGVEQTQQTVYRLISQSMMI 376
Cdd:COG0840   316 ELAEEASELAEEGGEVV--EEAVEGIEEIRESVEETAETIEELGESSQEI 363
Cof super family cl43184
Hydroxymethylpyrimidine pyrophosphatase and other HAD family phosphatases [Coenzyme transport ...
 494-530 7.39e-03

Hydroxymethylpyrimidine pyrophosphatase and other HAD family phosphatases [Coenzyme transport and metabolism, General function prediction only];


The actual alignment was detected with superfamily member COG0561:

Pssm-ID: 440327 [Multi-domain]  Cd Length: 192  Bit Score: 37.81  E-value: 7.39e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1444982458 494 QRVGMPVVMADADWPLLKNADWVIDTVEHGGVAATLQ 530
Cdd:COG0561   154 EAAGLGVAMGNAPPEVKAAADYVTGSNDEDGVAEALE 190
 
Name Accession Description Interval E-value
PlsC COG0204
1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; ...
 1-209 4.68e-53

1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; 1-acyl-sn-glycerol-3-phosphate acyltransferase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 439974 [Multi-domain]  Cd Length: 215  Bit Score: 179.43  E-value: 4.68e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1444982458   1 MFKDPVYLTIIGLARTVFFAQGLKFTVKGWENVPKDSGAVLVTNHTGYMDFTYVGLPFRKHrrfVRFMAKKEVFDHSVAG 80
Cdd:COG0204     7 LLRRFRYRLVRLWARLLLRLLGVRVRVEGLENLPADGPVLIVANHQSWLDILLLLAALPRP---VRFVAKKELFKIPLLG 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1444982458  81 PIMRACKHIPVDRTDGS---KSFEEACAKLENDELVGIFPESTISRSFEVKNLKSGAVRMAQRTGKPIIPVLIVGSQRVW 157
Cdd:COG0204    84 WLLRALGAIPVDRSKRRaalRALRQAVEALKAGESLVIFPEGTRSPDGRLLPFKTGAARLALEAGVPIVPVAIDGTERAL 163

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1444982458 158 TKGHPKHLGRsntpIHITVLPPWTPEG----DPAEATEKLHEIMDQGVRQLWDEYA 209
Cdd:COG0204   164 PKGFLPRPGK----VTVRIGPPIDPSDlegeDRRELAERLRAAIEALLAELRAEAA 215
LPLAT_AGPAT-like cd07989
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; ...
 14-199 9.15e-47

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), Tafazzin (product of Barth syndrome gene), and similar proteins.


Pssm-ID: 153251 [Multi-domain]  Cd Length: 184  Bit Score: 161.67  E-value: 9.15e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1444982458  14 ARTVFFAQGLKFTVKGWENVPKDSGAVLVTNHTGYMDFTYVGLPFRKHrrfVRFMAKKEVFDHSVAGPIMRACKHIPVDR 93
Cdd:cd07989     1 LRLLLRLLGVRVRVEGLENLPPKGPVIIVANHQSYLDPLVLGAALPRP---IRFVAKKELFKIPFLGWLLRLLGAIPIDR 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1444982458  94 TDGS---KSFEEACAKLENDELVGIFPESTISRSFEVKNLKSGAVRMAQRTGKPIIPVLIVGSQRVWTKGHPKHLGRsnt 170
Cdd:cd07989    78 GNGRsarEALREAIEALKEGESVVIFPEGTRSRDGELLPFKSGAFRLAKEAGVPIVPVAISGTWGSLPKGKKLPRPG--- 154

                         170       180
                  ....*....|....*....|....*....
gi 1444982458 171 PIHITVLPPWTPEGDpAEATEKLHEIMDQ 199
Cdd:cd07989   155 RVTVRIGEPIPPEGL-ELAEEDRKELREK 182
Acyltransferase pfam01553
Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis ...
 24-151 2.65e-35

Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis and other proteins of unknown function. This family also includes tafazzin, the Barth syndrome gene.


Pssm-ID: 366704 [Multi-domain]  Cd Length: 131  Bit Score: 128.94  E-value: 2.65e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1444982458  24 KFTVKGWENVPKDSGAVLVTNHTGYMDFTYVGLPFRKHRRFVRFMAKKEVFDHSVAGPIMRACKHIPVDRT---DGSKSF 100
Cdd:pfam01553   1 RIEVHGLENLPRGGPAIVVANHQSYLDVLLLSLALYKRGRPLVFVAKKELFDIPLVGWLMRLLGCIFIDRKnrkDAAGTL 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1444982458 101 EEACAKLENDELVGIFPESTISRSFEVKNLKSGAVRMAQRTGKPIIPVLIV 151
Cdd:pfam01553  81 EYLVELLREGKLVVIFPEGTRSREGELLPFKKGAFRLAIEAGVPIVPVAIS 131
PlsC smart00563
Phosphate acyltransferases; Function in phospholipid biosynthesis and have either ...
 39-153 9.04e-29

Phosphate acyltransferases; Function in phospholipid biosynthesis and have either glycerolphosphate, 1-acylglycerolphosphate, or 2-acylglycerolphosphoethanolamine acyltransferase activities. Tafazzin, the product of the gene mutated in patients with Barth syndrome, is a member of this family.


Pssm-ID: 214724 [Multi-domain]  Cd Length: 118  Bit Score: 110.52  E-value: 9.04e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1444982458   39 AVLVTNHTGYMDFTYVGLPFRKHRRFVRFMAKKEVFDHSVAGPIMRACKHIPVDRTDGSK---SFEEACAKLENDELVGI 115
Cdd:smart00563   1 ALVVANHQSFLDPLVLSALLPRKLGRVRFVAKKELFYVPLLGWLLRLLGAIFIDRSNGRKaraALREAVELLKEGEWLLI 80

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 1444982458  116 FPESTISRSFEVKNLKSGAVRMAQRTGKPIIPVLIVGS 153
Cdd:smart00563  81 FPEGTRSRPGKLLPFKKGAARLALEAGVPIVPVAIRGT 118
AGP_acyltrn TIGR00530
1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous ...
 22-151 8.99e-22

1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous region of a collection of related proteins, several of which are known to act as 1-acyl-sn-glycerol-3-phosphate acyltransferases (EC 2.3.1.51). Proteins scoring above the trusted cutoff are likely to have the same general activity. However, there is variation among characterized members as to whether the acyl group can be donated by acyl carrier protein or coenzyme A, and in the length and saturation of the donated acyl group. 1-acyl-sn-glycerol-3-phosphate acyltransferase is also called 1-AGP acyltransferase, lysophosphatidic acid acyltransferase, and LPA acyltransferase. [Fatty acid and phospholipid metabolism, Biosynthesis]


Pssm-ID: 129621 [Multi-domain]  Cd Length: 130  Bit Score: 90.87  E-value: 8.99e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1444982458  22 GLKFTVKGWENVPKDSGAVLVTNHTGYMDFTYVGlpfRKHRRFVRFMAKKEVFDHSVAGPIMRACKHIPVDR--TDGSKS 99
Cdd:TIGR00530   1 GLKVEVVGPENLPAKSPVLVVANHQSNLDPLTLS---AAFPPPIVFIAKKELKWIPFFGIMLWLTGAIFIDRenIRAIAT 77

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1444982458 100 FEEACAK-LENDELVGIFPESTISRSFEVKNLKSGAVRMAQRTGKPIIPVLIV 151
Cdd:TIGR00530  78 ALKAAIEvLKQGRSIGVFPEGTRSRGRDILPFKKGAFHIAIKAGVPILPVVLS 130
PRK08633 PRK08633
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated
 16-222 1.04e-20

2-acyl-glycerophospho-ethanolamine acyltransferase; Validated


Pssm-ID: 236315 [Multi-domain]  Cd Length: 1146  Bit Score: 96.53  E-value: 1.04e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1444982458   16 TVFFAQGLKFTVKGWENVPKDSGAVLVTNHTGYMDFTYVGL--PfrkhrRFVRFMAKKEVFDHSVAGPIMRACKHIPVDr 93
Cdd:PRK08633   420 LLLMHTRYRLRVEGRENIPAKGGALLLGNHVSWIDWALLQAasP-----RPIRFVMERSIYEKWYLKWFFKLFGVIPIS- 493

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1444982458   94 TDGSKSFEEACAK-LENDELVGIFPESTISRSFEVKNLKSGAVRMAQRTGKPIIPVLIVG---SQRVWTKGHPKHLGRSN 169
Cdd:PRK08633   494 SGGSKESLEFIRKaLDDGEVVCIFPEGAITRNGQLNEFKRGFELIVKGTDVPIIPFYIRGlwgSIFSRASGKFLWRWPTR 573

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1444982458  170 TPIHITVLppwtpEGDPAEATEKLHEiMDQGVRQL----WDEYAAEEGPLPKgaYWV 222
Cdd:PRK08633   574 IPYPVTVA-----FGKPMPAHSTAHE-VKQAVFELsfdsWKSRKEALPPLAE--AWI 622
Tar COG0840
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];
247-376 3.30e-04

Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];


Pssm-ID: 440602 [Multi-domain]  Cd Length: 533  Bit Score: 43.47  E-value: 3.30e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1444982458 247 RQRIRHLRGDLAAFKEKLAESAREFGDSAREFGDQTRQQfldASQTmsaesarrrEQTTALLAQFRQSVEQMADDVVAGA 326
Cdd:COG0840   248 IENLRELVGQVRESAEQVASASEELAASAEELAAGAEEQ---AASL---------EETAAAMEELSATVQEVAENAQQAA 315

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1444982458 327 KESKESVRTATDSMRVTfrEAYVQLEKASASGVEQTQQTVYRLISQSMMI 376
Cdd:COG0840   316 ELAEEASELAEEGGEVV--EEAVEGIEEIRESVEETAETIEELGESSQEI 363
Cof COG0561
Hydroxymethylpyrimidine pyrophosphatase and other HAD family phosphatases [Coenzyme transport ...
 494-530 7.39e-03

Hydroxymethylpyrimidine pyrophosphatase and other HAD family phosphatases [Coenzyme transport and metabolism, General function prediction only];


Pssm-ID: 440327 [Multi-domain]  Cd Length: 192  Bit Score: 37.81  E-value: 7.39e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1444982458 494 QRVGMPVVMADADWPLLKNADWVIDTVEHGGVAATLQ 530
Cdd:COG0561   154 EAAGLGVAMGNAPPEVKAAADYVTGSNDEDGVAEALE 190
growth_prot_Scy NF041483
polarized growth protein Scy;
187-394 8.90e-03

polarized growth protein Scy;


Pssm-ID: 469371 [Multi-domain]  Cd Length: 1293  Bit Score: 39.04  E-value: 8.90e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1444982458  187 AEATEKLHEIMDQG---VRQLWDEYAAEEGPLPKGAYWVPARLGGGAptfeEAQAEDLKVEEERQRIRhLRGDLAAFKEK 263
Cdd:NF041483   618 TEAAERIRTLQAQAeqeAERLRTEAAADASAARAEGENVAVRLRSEA----AAEAERLKSEAQESADR-VRAEAAAAAER 692

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1444982458  264 LA------------ESAR------EFGDSAREFGDQTRQQFLDASQTMSAESARRREQTTALLAQFRQSVEQMADDVVAG 325
Cdd:NF041483   693 VGteaaealaaaqeEAARrrreaeETLGSARAEADQERERAREQSEELLASARKRVEEAQAEAQRLVEEADRRATELVSA 772

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1444982458  326 AKESKESVRTATDSMRVTFREAYVQLEKASASGVEQT----QQTVYRLISQSMMIRDKLPQRLNRLIT-AQPET 394
Cdd:NF041483   773 AEQTAQQVRDSVAGLQEQAEEEIAGLRSAAEHAAERTrteaQEEADRVRSDAYAERERASEDANRLRReAQEET 846
 
Name Accession Description Interval E-value
PlsC COG0204
1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; ...
 1-209 4.68e-53

1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; 1-acyl-sn-glycerol-3-phosphate acyltransferase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 439974 [Multi-domain]  Cd Length: 215  Bit Score: 179.43  E-value: 4.68e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1444982458   1 MFKDPVYLTIIGLARTVFFAQGLKFTVKGWENVPKDSGAVLVTNHTGYMDFTYVGLPFRKHrrfVRFMAKKEVFDHSVAG 80
Cdd:COG0204     7 LLRRFRYRLVRLWARLLLRLLGVRVRVEGLENLPADGPVLIVANHQSWLDILLLLAALPRP---VRFVAKKELFKIPLLG 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1444982458  81 PIMRACKHIPVDRTDGS---KSFEEACAKLENDELVGIFPESTISRSFEVKNLKSGAVRMAQRTGKPIIPVLIVGSQRVW 157
Cdd:COG0204    84 WLLRALGAIPVDRSKRRaalRALRQAVEALKAGESLVIFPEGTRSPDGRLLPFKTGAARLALEAGVPIVPVAIDGTERAL 163

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1444982458 158 TKGHPKHLGRsntpIHITVLPPWTPEG----DPAEATEKLHEIMDQGVRQLWDEYA 209
Cdd:COG0204   164 PKGFLPRPGK----VTVRIGPPIDPSDlegeDRRELAERLRAAIEALLAELRAEAA 215
LPLAT_AGPAT-like cd07989
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; ...
 14-199 9.15e-47

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), Tafazzin (product of Barth syndrome gene), and similar proteins.


Pssm-ID: 153251 [Multi-domain]  Cd Length: 184  Bit Score: 161.67  E-value: 9.15e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1444982458  14 ARTVFFAQGLKFTVKGWENVPKDSGAVLVTNHTGYMDFTYVGLPFRKHrrfVRFMAKKEVFDHSVAGPIMRACKHIPVDR 93
Cdd:cd07989     1 LRLLLRLLGVRVRVEGLENLPPKGPVIIVANHQSYLDPLVLGAALPRP---IRFVAKKELFKIPFLGWLLRLLGAIPIDR 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1444982458  94 TDGS---KSFEEACAKLENDELVGIFPESTISRSFEVKNLKSGAVRMAQRTGKPIIPVLIVGSQRVWTKGHPKHLGRsnt 170
Cdd:cd07989    78 GNGRsarEALREAIEALKEGESVVIFPEGTRSRDGELLPFKSGAFRLAKEAGVPIVPVAISGTWGSLPKGKKLPRPG--- 154

                         170       180
                  ....*....|....*....|....*....
gi 1444982458 171 PIHITVLPPWTPEGDpAEATEKLHEIMDQ 199
Cdd:cd07989   155 RVTVRIGEPIPPEGL-ELAEEDRKELREK 182
Acyltransferase pfam01553
Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis ...
 24-151 2.65e-35

Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis and other proteins of unknown function. This family also includes tafazzin, the Barth syndrome gene.


Pssm-ID: 366704 [Multi-domain]  Cd Length: 131  Bit Score: 128.94  E-value: 2.65e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1444982458  24 KFTVKGWENVPKDSGAVLVTNHTGYMDFTYVGLPFRKHRRFVRFMAKKEVFDHSVAGPIMRACKHIPVDRT---DGSKSF 100
Cdd:pfam01553   1 RIEVHGLENLPRGGPAIVVANHQSYLDVLLLSLALYKRGRPLVFVAKKELFDIPLVGWLMRLLGCIFIDRKnrkDAAGTL 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1444982458 101 EEACAKLENDELVGIFPESTISRSFEVKNLKSGAVRMAQRTGKPIIPVLIV 151
Cdd:pfam01553  81 EYLVELLREGKLVVIFPEGTRSREGELLPFKKGAFRLAIEAGVPIVPVAIS 131
PlsC smart00563
Phosphate acyltransferases; Function in phospholipid biosynthesis and have either ...
 39-153 9.04e-29

Phosphate acyltransferases; Function in phospholipid biosynthesis and have either glycerolphosphate, 1-acylglycerolphosphate, or 2-acylglycerolphosphoethanolamine acyltransferase activities. Tafazzin, the product of the gene mutated in patients with Barth syndrome, is a member of this family.


Pssm-ID: 214724 [Multi-domain]  Cd Length: 118  Bit Score: 110.52  E-value: 9.04e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1444982458   39 AVLVTNHTGYMDFTYVGLPFRKHRRFVRFMAKKEVFDHSVAGPIMRACKHIPVDRTDGSK---SFEEACAKLENDELVGI 115
Cdd:smart00563   1 ALVVANHQSFLDPLVLSALLPRKLGRVRFVAKKELFYVPLLGWLLRLLGAIFIDRSNGRKaraALREAVELLKEGEWLLI 80

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 1444982458  116 FPESTISRSFEVKNLKSGAVRMAQRTGKPIIPVLIVGS 153
Cdd:smart00563  81 FPEGTRSRPGKLLPFKKGAARLALEAGVPIVPVAIRGT 118
AGP_acyltrn TIGR00530
1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous ...
 22-151 8.99e-22

1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous region of a collection of related proteins, several of which are known to act as 1-acyl-sn-glycerol-3-phosphate acyltransferases (EC 2.3.1.51). Proteins scoring above the trusted cutoff are likely to have the same general activity. However, there is variation among characterized members as to whether the acyl group can be donated by acyl carrier protein or coenzyme A, and in the length and saturation of the donated acyl group. 1-acyl-sn-glycerol-3-phosphate acyltransferase is also called 1-AGP acyltransferase, lysophosphatidic acid acyltransferase, and LPA acyltransferase. [Fatty acid and phospholipid metabolism, Biosynthesis]


Pssm-ID: 129621 [Multi-domain]  Cd Length: 130  Bit Score: 90.87  E-value: 8.99e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1444982458  22 GLKFTVKGWENVPKDSGAVLVTNHTGYMDFTYVGlpfRKHRRFVRFMAKKEVFDHSVAGPIMRACKHIPVDR--TDGSKS 99
Cdd:TIGR00530   1 GLKVEVVGPENLPAKSPVLVVANHQSNLDPLTLS---AAFPPPIVFIAKKELKWIPFFGIMLWLTGAIFIDRenIRAIAT 77

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1444982458 100 FEEACAK-LENDELVGIFPESTISRSFEVKNLKSGAVRMAQRTGKPIIPVLIV 151
Cdd:TIGR00530  78 ALKAAIEvLKQGRSIGVFPEGTRSRGRDILPFKKGAFHIAIKAGVPILPVVLS 130
PRK08633 PRK08633
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated
 16-222 1.04e-20

2-acyl-glycerophospho-ethanolamine acyltransferase; Validated


Pssm-ID: 236315 [Multi-domain]  Cd Length: 1146  Bit Score: 96.53  E-value: 1.04e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1444982458   16 TVFFAQGLKFTVKGWENVPKDSGAVLVTNHTGYMDFTYVGL--PfrkhrRFVRFMAKKEVFDHSVAGPIMRACKHIPVDr 93
Cdd:PRK08633   420 LLLMHTRYRLRVEGRENIPAKGGALLLGNHVSWIDWALLQAasP-----RPIRFVMERSIYEKWYLKWFFKLFGVIPIS- 493

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1444982458   94 TDGSKSFEEACAK-LENDELVGIFPESTISRSFEVKNLKSGAVRMAQRTGKPIIPVLIVG---SQRVWTKGHPKHLGRSN 169
Cdd:PRK08633   494 SGGSKESLEFIRKaLDDGEVVCIFPEGAITRNGQLNEFKRGFELIVKGTDVPIIPFYIRGlwgSIFSRASGKFLWRWPTR 573

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1444982458  170 TPIHITVLppwtpEGDPAEATEKLHEiMDQGVRQL----WDEYAAEEGPLPKgaYWV 222
Cdd:PRK08633   574 IPYPVTVA-----FGKPMPAHSTAHE-VKQAVFELsfdsWKSRKEALPPLAE--AWI 622
PLN02901 PLN02901
1-acyl-sn-glycerol-3-phosphate acyltransferase
 24-160 2.69e-15

1-acyl-sn-glycerol-3-phosphate acyltransferase


Pssm-ID: 215488 [Multi-domain]  Cd Length: 214  Bit Score: 74.77  E-value: 2.69e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1444982458  24 KFTVKGWENVPK-DSGAVLVTNHTGYMD-FTYVGLpfrkhRRFVRFMAKKEVFDHSVAGPIMRACKHIPVDRTDgSKSFE 101
Cdd:PLN02901   36 KIEVEGLENLPSpDEPAVYVSNHQSFLDiYTLFHL-----GRPFKFISKTSIFLIPIIGWAMYMTGHIPLKRMD-RRSQL 109

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1444982458 102 EaCAK-----LENDELVGIFPESTISRSFEVKNLKSGAVRMAQRTGKPIIPVLIVGSQRVWTKG 160
Cdd:PLN02901  110 E-CLKrcmelLKKGASVFFFPEGTRSKDGKLAAFKKGAFSVAAKTGVPVVPITLVGTGKIMPNG 172
LPLAT cd06551
Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; ...
 19-198 1.93e-14

Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Lysophospholipid acyltransferase (LPLAT) superfamily members are acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis. These proteins catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this superfamily are LPLATs such as glycerol-3-phosphate 1-acyltransferase (GPAT, PlsB), 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), lysophosphatidylcholine acyltransferase 1 (LPCAT-1), lysophosphatidylethanolamine acyltransferase (LPEAT, also known as, MBOAT2, membrane-bound O-acyltransferase domain-containing protein 2), lipid A biosynthesis lauroyl/myristoyl acyltransferase, 2-acylglycerol O-acyltransferase (MGAT), dihydroxyacetone phosphate acyltransferase (DHAPAT, also known as 1 glycerol-3-phosphate O-acyltransferase 1) and Tafazzin (the protein product of the Barth syndrome (TAZ) gene).


Pssm-ID: 153244 [Multi-domain]  Cd Length: 187  Bit Score: 71.68  E-value: 1.93e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1444982458  19 FAQGLKFTVKGWENVPKDSGAVLVTNHTGYMDFTYVG-LPFRKHRRFVRFMAKKEvfdHSVAGPIMRACKHIPVDRTDG- 96
Cdd:cd06551     8 FFGFVRLEVKGPPPPPGGGPVLFVSNHSSWWDGLILFlLLERGLRRDVYGLMDEE---LLERYPFFTRLGAFSVDRDSPr 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1444982458  97 --SKSFEEACAKLEN-DELVGIFPESTISRsFEVKNL--KSGAVRMAQRTGKPIIPVLIVGSQRVWTKGHpkhlgrsntP 171
Cdd:cd06551    85 saAKSLKYVARLLSKpGSVVWIFPEGTRTR-RDKRPLqfKPGVAHLAEKAGVPIVPVALRYTFELFEQFP---------E 154

                         170       180       190
                  ....*....|....*....|....*....|...
gi 1444982458 172 IHITVLPPWTPEGD------PAEATEKLHEIMD 198
Cdd:cd06551   155 IFVRIGPPIPYAETalgeelAAELANRLTRLLD 187
LPLAT_MGAT-like cd07987
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; ...
 25-208 6.44e-14

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this suubgroup are such LPLATs as 2-acylglycerol O-acyltransferase (MGAT), and similar proteins.


Pssm-ID: 153249 [Multi-domain]  Cd Length: 212  Bit Score: 70.78  E-value: 6.44e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1444982458  25 FTVKGWENVPKDSGAVLVTNHTGY-MDFTYVGLPFR-KHR-RFVRFMAKKEVFDHSVAGPIMRACKHIPVDRtdgsKSFE 101
Cdd:cd07987     8 YEVRGLENIPDEGPALLVHPHGGLpIDGALLAAAFLlLFPgRLPRALADHFLFPLPGLRDLLRRLGAVPGSR----ENCV 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1444982458 102 EAcakLENDELVGIFP----ESTIS-RSFEVKNLKS--GAVRMAQRTGKPIIPVLIVG---SQRVWTKGHPKHLGRS--- 168
Cdd:cd07987    84 RL---LREGELVLIFPggarEALKSkREEYYLLWKKrkGFARLALRAGAPIVPVFTFGeeeLFRVLGDPDGPVGKRLfrl 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 1444982458 169 -----NTPIHI-----TVLPPWTPEGDPAEATEKLHEIMDQGVRQLWDEY 208
Cdd:cd07987   161 lplprRLPLYPvfgepIVVPRPPIPDPPDEDVEELHQKYIAALRELIEKH 210
LPLAT_ACT14924-like cd07986
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ...
 23-195 8.91e-14

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ACT14924; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are uncharacterized phospholipid/glycerol acyltransferases such as the Pectobacterium carotovorum subsp. carotovorum PC1 locus ACT14924 putative acyltransferase, and similar proteins.


Pssm-ID: 153248 [Multi-domain]  Cd Length: 210  Bit Score: 70.35  E-value: 8.91e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1444982458  23 LKFTVKGWENVPKDSGAVLVTNH-TGYMDftyvGLPF----RKHRRFVRFMAKkevFDHSVAGPIMRACkhIPVDRTDG- 96
Cdd:cd07986     8 LEVDVSGLENIPKDGPVVIVANHpFGILD----GLILadllGSVRPDVRILAN---QLLSKIPELRDLF--IPVDPLEGr 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1444982458  97 ------SKSFEEACAKLENDELVGIFPESTISRSFEVKN------LKSGAVRMAQRTGKPIIPVLIVGSQRVW----TKG 160
Cdd:cd07986    79 aalaknRESLREALRHLKNGGALIIFPAGRVSTASPPFGrvsdrpWNPFVARLARKAKAPVVPVYFSGRNSRLfylaGLI 158

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 1444982458 161 HPK---------HLGRSNTPIHITVLPPWTPE-----GDPAEATEKLHE 195
Cdd:cd07986   159 HPTlrtlllpreLLNKRGKTIRIRVGRPIPPEelarfEDAEELADFLRL 207
LPLAT_ABO13168-like cd07988
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ...
 25-185 5.63e-13

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ABO13168; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are uncharacterized phospholipid/glycerol acyltransferases such as the Acinetobacter baumannii ATCC 17978 locus ABO13168 putative acyltransferase, and similar proteins.


Pssm-ID: 153250 [Multi-domain]  Cd Length: 163  Bit Score: 66.86  E-value: 5.63e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1444982458  25 FTVKGW------ENVPKdsGAVLVTNHTGYMDFTY-VGLPFRKHRRfVRFMAKKEVFDHSVaGPIMRACKHIPVDRTDGS 97
Cdd:cd07988     5 LRLSGWriegepPNKPK--FVVIGAPHTSNWDFVLgLLAAFALGLK-ISFLGKHSLFKPPL-GPFMRWLGGIPVDRSRAG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1444982458  98 KSFEEACAKLENDE--LVGIFPESTisRSFeVKNLKSGAVRMAQRTGKPIIPVLIVGSQRvwtkghpkhlgrsntpiHIT 175
Cdd:cd07988    81 GLVEQVVEEFRRREefVLAIAPEGT--RSK-VDKWKTGFYHIARGAGVPILLVYLDYKRK-----------------TVG 140

                         170
                  ....*....|
gi 1444982458 176 VLPPWTPEGD 185
Cdd:cd07988   141 IGPLFEPSGD 150
LPLAT_AAK14816-like cd07992
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ...
 26-195 7.10e-13

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown AAK14816-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are uncharacterized glycerol-3-phosphate acyltransferases such as the Plasmodium falciparum locus AAK14816 putative acyltransferase, and similar proteins.


Pssm-ID: 153254 [Multi-domain]  Cd Length: 203  Bit Score: 67.67  E-value: 7.10e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1444982458  26 TVKGWENVPKDSGAVLVTNHTGymDFTYVGLPFRKHRRFVRFMAKKEVFDHSVAGPIMRACKHIPVDR-----------T 94
Cdd:cd07992    17 TVVGRENVPKDGPVIFLGNHPN--ALIDPLLLAATLRRPVRFLAKADLFKNPLIGWLLESFGAIPVYRpkdlarggigkI 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1444982458  95 DGSKSFEEACAKLENDELVGIFPESTISRSFEVKNLKSGAVRMA-QRTGKPIIPVLIVGSQRVWTKghpKHLGRSN---- 169
Cdd:cd07992    95 SNAAVFDAVGEALKAGGAIGIFPEGGSHDRPRLLPLKAGAARMAlEALEAGQKDVKIVPVGLNYED---KSRFRSRvlve 171

                         170       180
                  ....*....|....*....|....*...
gi 1444982458 170 --TPIHITvlpPWTPEGDPAEATEKLHE 195
Cdd:cd07992   172 fgKPISVS---AFEEAEASRDVEKKLIN 196
LPLAT_LPCAT1-like cd07991
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like; ...
 14-191 1.10e-12

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as lysophosphatidylcholine acyltransferase 1 (LPCAT-1), glycerol-3-phosphate acyltransferase 3 (GPAT3), and similar sequences.


Pssm-ID: 153253 [Multi-domain]  Cd Length: 211  Bit Score: 67.25  E-value: 1.10e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1444982458  14 ARTVFFAQGL-KFTVKGWENVPKDSGaVLVTNHTGYMDFTYVGLpfrkhRRFVRFMAKKEVFDHSVAGPIMRACKHIPVD 92
Cdd:cd07991     1 ARVLLFAFGFyVIKVHGKPDPPEAPR-IIVANHTSFIDPLILFS-----DLFPSIVAKKELGKLPFIGTILRALGCIFVD 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1444982458  93 RTDGSKSF---EEACAKLENDEL--VGIFPESTIS-RSFEVKnLKSGAVrmaqRTGKPIIPVLIVGSQRV-------WTK 159
Cdd:cd07991    75 RSEPKDRKkvvEEIKERATDPNWppILIFPEGTTTnGKALIM-FKKGAF----EPGVPVQPVAIRYPNKFvdafwnsSGY 149

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 1444982458 160 GHPKHLGR----SNTPIHITVLPPWTPEGDPAEATE 191
Cdd:cd07991   150 SSLMYLFRlltqPANVLEVEFLPVYTPSEEGEDPKE 185
PRK06814 PRK06814
acyl-[ACP]--phospholipid O-acyltransferase;
27-197 1.21e-09

acyl-[ACP]--phospholipid O-acyltransferase;


Pssm-ID: 235865 [Multi-domain]  Cd Length: 1140  Bit Score: 61.13  E-value: 1.21e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1444982458   27 VKGWENVPK-DSGAVLVTNHTGYMDFTYVGLPFRKHRRFVrfmakkevFDHSVAG-----PIMRACKHIPVDRTD--GSK 98
Cdd:PRK06814   443 VKGLENLQKaGKKAVIAANHVSFLDGPLLAAYLPEEPTFA--------IDTDIAKawwvkPFLKLAKALPVDPTNpmATR 514

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1444982458   99 SFEEAcakLENDELVGIFPESTISRSFEVKNLKSGAVRMAQRTGKPIIPVLIVGSQRV---WTKGHPKhlgRSNTP-IHI 174
Cdd:PRK06814   515 TLIKE---VQKGEKLVIFPEGRITVTGSLMKIYDGPGMIADKAGAMVVPVRIDGLQFThfsRLKNQVR---RKWFPkVTV 588

                          170       180       190
                   ....*....|....*....|....*....|.
gi 1444982458  175 TVLPPWTPEGDPA--------EATEKLHEIM 197
Cdd:PRK06814   589 TILPPVKLAVDPElkgrerrsAAGAALYDIM 619
COG3176 COG3176
Putative hemolysin [General function prediction only];
31-193 8.46e-07

Putative hemolysin [General function prediction only];


Pssm-ID: 442409  Cd Length: 270  Bit Score: 50.81  E-value: 8.46e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1444982458  31 ENVPKDSGAVLVTNH-----TGYMDFTYVGlpfrKHRRFVRFMAKkevFDHSVAGPIMRACKHIPVDRtDGSKSFEEACA 105
Cdd:COG3176    65 DRIDADGHLLVVANHplgilDGLALLKLVG----TVRPDYRILAN---DLALRIPGGFYSELEFPVDP-FNLETLKAARR 136

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1444982458 106 KLENDELVGIFPESTISRSFEVKNL--KSGAVRMAQRTGKPIIPVLIVGsqrvWTKG--------HPK---------HLG 166
Cdd:COG3176   137 HLLEGGRSCVFPAGRVSGARRVIDLlwSGLAAKLARKAGAPVVPVYFDG----RNSGlfylfgsiHPTlrtaalpreLLR 212

                         170       180       190
                  ....*....|....*....|....*....|..
gi 1444982458 167 RSNTPIHITVLPPWTPE-----GDPAEATEKL 193
Cdd:COG3176   213 KRGHLIELRVGRPIPPLeldldLDPAELPPLL 244
LPLAT_LABLAT-like cd07984
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; ...
 24-205 3.13e-06

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as lipid A biosynthesis lauroyl/myristoyl (LABLAT, HtrB) acyltransferases and similar proteins.


Pssm-ID: 153246 [Multi-domain]  Cd Length: 192  Bit Score: 47.98  E-value: 3.13e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1444982458  24 KFTVKGWENVP----KDSGAVLVTNHTGYMDFtyVGLPFRKHRRFVRFMAKK---EVFDHSVAGpIMRACKHIPVDRTDG 96
Cdd:cd07984     3 RVEREGLEHLEaalaKGKGVILLTAHFGNWEL--AGLALALLGYPVTVVYRPlknPLLDRLITR-GRERFGARLIPRGGG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1444982458  97 SKSFEEAcakLENDELVGIFP--ESTISRSFEVK--NLK----SGAVRMAQRTGKPIIPVLIVgsqRVWTKGHpkhlgrs 168
Cdd:cd07984    80 LRELIRA---LKKGEIVGILPdqDPGRKGGVFVPffGRPaatpTGPARLALKTGAPVVPAFAY---RLPGGGY------- 146

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1444982458 169 ntpiHITVLPPW--TPEGDPAEATEKLHEIMDQGVRQ-----LW 205
Cdd:cd07984   147 ----RIEFEPPLenPPSEDVEEDTQRLNDALEAAIREhpeqwLW 186
LpxP COG1560
Palmitoleoyl-ACP: Kdo2-lipid-IV acyltransferase (lipid A biosynthesis) [Lipid transport and ...
 25-205 2.50e-04

Palmitoleoyl-ACP: Kdo2-lipid-IV acyltransferase (lipid A biosynthesis) [Lipid transport and metabolism]; Palmitoleoyl-ACP: Kdo2-lipid-IV acyltransferase (lipid A biosynthesis) is part of the Pathway/BioSystem: Lipid A biosynthesis


Pssm-ID: 441168 [Multi-domain]  Cd Length: 271  Bit Score: 42.87  E-value: 2.50e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1444982458  25 FTVKGWENV----PKDSGAVLVTNHTGYMD-----FTYVGLPF----RKHRRfvrfmakKEVFDHSVAGpIMRACKHIpV 91
Cdd:COG1560    84 VEVEGLEHLeaalAEGRGVILLTPHFGNWElagaaLALRGYPVtavyRPLKN-------PLLDRLIRRG-RERFGGEL-I 154

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1444982458  92 DRTDGSKSFEEAcakLENDELVGIFP--ESTISRSFEV------KNLKSGAVRMAQRTGKPIIPVlivgsqrvwtkgHPK 163
Cdd:COG1560   155 PRKDGVRALLRA---LRKGGIVGLLPdqDPGRKSGVFVpffgvpAATPTGPARLARRTGAPVVPV------------FAR 219

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 1444982458 164 HLGRsNTPIHITVLPPWT-PEGDPAEATEKLHEIMDQGVRQ-----LW 205
Cdd:COG1560   220 RLPD-GRGYRLEIEPPLEdFSEDVEADTQRLNRALEAWIREhpeqwLW 266
Tar COG0840
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];
247-376 3.30e-04

Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];


Pssm-ID: 440602 [Multi-domain]  Cd Length: 533  Bit Score: 43.47  E-value: 3.30e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1444982458 247 RQRIRHLRGDLAAFKEKLAESAREFGDSAREFGDQTRQQfldASQTmsaesarrrEQTTALLAQFRQSVEQMADDVVAGA 326
Cdd:COG0840   248 IENLRELVGQVRESAEQVASASEELAASAEELAAGAEEQ---AASL---------EETAAAMEELSATVQEVAENAQQAA 315

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1444982458 327 KESKESVRTATDSMRVTfrEAYVQLEKASASGVEQTQQTVYRLISQSMMI 376
Cdd:COG0840   316 ELAEEASELAEEGGEVV--EEAVEGIEEIRESVEETAETIEELGESSQEI 363
PRK08043 PRK08043
bifunctional acyl-ACP--phospholipid O-acyltransferase/long-chain-fatty-acid--ACP ligase;
113-197 3.82e-04

bifunctional acyl-ACP--phospholipid O-acyltransferase/long-chain-fatty-acid--ACP ligase;


Pssm-ID: 181207 [Multi-domain]  Cd Length: 718  Bit Score: 43.16  E-value: 3.82e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1444982458 113 VGIFPESTISRSFEVKNLKSGAVRMAQRTGKPIIPVLIVGSQRVwtkghpkHLGRSN--------TPIHITVLPPWT--- 181
Cdd:PRK08043  100 VVIFPEGRITVTGSLMKIYDGAGFVAAKSGATVIPVRIEGAELT-------HFSRLKglvkrrlfPQITLHILPPTQlpm 172

                          90       100
                  ....*....|....*....|.
gi 1444982458 182 PEGDPAE-----ATEKLHEIM 197
Cdd:PRK08043  173 PDAPRARdrrklAGEMLHQIM 193
LPLAT_LCLAT1-like cd07990
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; ...
 22-129 7.64e-04

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as Lysocardiolipin acyltransferase 1 (LCLAT1) or 1-acyl-sn-glycerol-3-phosphate acyltransferase and similar proteins.


Pssm-ID: 153252 [Multi-domain]  Cd Length: 193  Bit Score: 40.68  E-value: 7.64e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1444982458  22 GLKFTVKGWENVPKDSGAVLVTNHTGYMDFTYVGLPFRKHRRF--VRFMAKKEVFDHSVAGPIMRACKHIPVDRT--DGS 97
Cdd:cd07990     9 GVKVVVYGDEPKLPKERALIISNHRSEVDWLVLWMLADRFGRLgrLKIVLKDSLKYPPLGGWGWQLGEFIFLKRKweKDE 88

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1444982458  98 KSFEEACAKLENDE----LVgIFPEST--------ISRSFEVKN 129
Cdd:cd07990    89 KTIKRQLKRLKDSPepfwLL-IFPEGTrfteekkeRSQEFAEKN 131
Cof COG0561
Hydroxymethylpyrimidine pyrophosphatase and other HAD family phosphatases [Coenzyme transport ...
 494-530 7.39e-03

Hydroxymethylpyrimidine pyrophosphatase and other HAD family phosphatases [Coenzyme transport and metabolism, General function prediction only];


Pssm-ID: 440327 [Multi-domain]  Cd Length: 192  Bit Score: 37.81  E-value: 7.39e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1444982458 494 QRVGMPVVMADADWPLLKNADWVIDTVEHGGVAATLQ 530
Cdd:COG0561   154 EAAGLGVAMGNAPPEVKAAADYVTGSNDEDGVAEALE 190
growth_prot_Scy NF041483
polarized growth protein Scy;
187-394 8.90e-03

polarized growth protein Scy;


Pssm-ID: 469371 [Multi-domain]  Cd Length: 1293  Bit Score: 39.04  E-value: 8.90e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1444982458  187 AEATEKLHEIMDQG---VRQLWDEYAAEEGPLPKGAYWVPARLGGGAptfeEAQAEDLKVEEERQRIRhLRGDLAAFKEK 263
Cdd:NF041483   618 TEAAERIRTLQAQAeqeAERLRTEAAADASAARAEGENVAVRLRSEA----AAEAERLKSEAQESADR-VRAEAAAAAER 692

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1444982458  264 LA------------ESAR------EFGDSAREFGDQTRQQFLDASQTMSAESARRREQTTALLAQFRQSVEQMADDVVAG 325
Cdd:NF041483   693 VGteaaealaaaqeEAARrrreaeETLGSARAEADQERERAREQSEELLASARKRVEEAQAEAQRLVEEADRRATELVSA 772

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1444982458  326 AKESKESVRTATDSMRVTFREAYVQLEKASASGVEQT----QQTVYRLISQSMMIRDKLPQRLNRLIT-AQPET 394
Cdd:NF041483   773 AEQTAQQVRDSVAGLQEQAEEEIAGLRSAAEHAAERTrteaQEEADRVRSDAYAERERASEDANRLRReAQEET 846
LPLAT_DUF374-like cd07983
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: DUF374; ...
 131-199 9.88e-03

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: DUF374; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are the uncharacterized DUF374 phospholipid/glycerol acyltransferases and similar proteins.


Pssm-ID: 153245 [Multi-domain]  Cd Length: 189  Bit Score: 37.58  E-value: 9.88e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1444982458 131 KSGAVRMAQRTGKPIIPVLIVGSqRVWTKGH------PKHLGRSN----TPIHItvlPPWTPEGDPAEATEKLHEIMDQ 199
Cdd:cd07983   115 KPGVILLARKSGAPIVPVAIAAS-RAWRLKSwdrfiiPKPFSRVVivfgEPIHV---PPDADEEELEEYRLELEAALNA 189
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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