|
Name |
Accession |
Description |
Interval |
E-value |
| WalK |
COG5002 |
Sensor histidine kinase WalK [Signal transduction mechanisms]; |
58-378 |
3.29e-65 |
|
Sensor histidine kinase WalK [Signal transduction mechanisms];
Pssm-ID: 444026 [Multi-domain] Cd Length: 390 Bit Score: 212.49 E-value: 3.29e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447491076 58 ELSAIIVFATAIAFVMAWFLLKVGLSGWIAMPLTLAVALGITYAFSRGLTSPLRQMRDAAETMADGDYSVRVQIESRKDE 137
Cdd:COG5002 59 LLLLLLLLALLLLLLLLLLLLALALLLLALLLLLLLLLLLLALLILLLLLALLILLAALLLLLSELLLLLLLLGRLSLRL 138
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447491076 138 VGKLTLAFNEMA-----EELEHADNMRRDLIANVSHELRTPVSALQAMVENLADGVVEPTPSN---MEAIVNQTHKLADL 209
Cdd:COG5002 139 SALLLGLLLLAAverdiTELERLEQMRREFVANVSHELRTPLTSIRGYLELLLDGAADDPEERreyLEIILEEAERLSRL 218
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447491076 210 ITFLLDLSRVEAGAESLVITSFDFKDFINNIVETVKIADAGHNHSISLNI-ENNIMLVGDKNRLSQLFTNVVSNAIKHSA 288
Cdd:COG5002 219 VNDLLDLSRLESGELKLEKEPVDLAELLEEVVEELRPLAEEKGIELELDLpEDPLLVLGDPDRLEQVLTNLLDNAIKYTP 298
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447491076 289 DNTKILISAKSnhEKNILVCNVINFGTQIPEENRADIFRRFVKGNQGMGTESGGTGLGLSIARWAALLHHGNIRVVDDK- 367
Cdd:COG5002 299 EGGTITVSLRE--EDDQVRISVRDTGIGIPEEDLPRIFERFYRVDKSRSRETGGTGLGLAIVKHIVEAHGGRIWVESEPg 376
|
330
....*....|.
gi 1447491076 368 RGVNFEITLPL 378
Cdd:COG5002 377 KGTTFTITLPL 387
|
|
| KdpD |
COG2205 |
K+-sensing histidine kinase KdpD [Signal transduction mechanisms]; |
144-379 |
1.12e-62 |
|
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
Pssm-ID: 441807 [Multi-domain] Cd Length: 239 Bit Score: 200.90 E-value: 1.12e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447491076 144 AFNEMAEELEHADNMRRDLIANVSHELRTPVSALQAMVENLADGVVEPTP---SNMEAIVNQTHKLADLITFLLDLSRVE 220
Cdd:COG2205 1 ELEEALEELEELERLKSEFLANVSHELRTPLTSILGAAELLLDEEDLSPEerrELLEIIRESAERLLRLIEDLLDLSRLE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447491076 221 AGAESLVITSFDFKDFINNIVETVKIADAGHNHSISLNI-ENNIMLVGDKNRLSQLFTNVVSNAIKHSADNTKILISAKS 299
Cdd:COG2205 81 SGKLSLELEPVDLAELLEEAVEELRPLAEEKGIRLELDLpPELPLVYADPELLEQVLANLLDNAIKYSPPGGTITISARR 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447491076 300 NHEKniLVCNVINFGTQIPEENRADIFRRFVKGNQgmGTESGGTGLGLSIARWAALLHHGNIRVVDDK-RGVNFEITLPL 378
Cdd:COG2205 161 EGDG--VRISVSDNGPGIPEEELERIFERFYRGDN--SRGEGGTGLGLAIVKRIVEAHGGTIWVESEPgGGTTFTVTLPL 236
|
.
gi 1447491076 379 T 379
Cdd:COG2205 237 A 237
|
|
| BaeS |
COG0642 |
Signal transduction histidine kinase [Signal transduction mechanisms]; |
59-379 |
1.26e-62 |
|
Signal transduction histidine kinase [Signal transduction mechanisms];
Pssm-ID: 440407 [Multi-domain] Cd Length: 328 Bit Score: 203.60 E-value: 1.26e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447491076 59 LSAIIVFATAIAFVMAWFLLKVGLSGWIAMPLTLAVALGITYAFSRGLTSPLRQMRDAAETMADGDYSVRVQIESRKDEV 138
Cdd:COG0642 10 LLLLLLLLLLLALLLLLLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLLLLLLLLLLL 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447491076 139 GKLTLAFNEMAEELEHADNMRRDLIANVSHELRTPVSALQAMVENLADGVVEPTPSNMEAIVNQTHKLADLITFLLDLSR 218
Cdd:COG0642 90 LLLLLLLLALLLLLEEANEAKSRFLANVSHELRTPLTAIRGYLELLLEELDEEQREYLETILRSADRLLRLINDLLDLSR 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447491076 219 VEAGAESLVITSFDFKDFINNIVETVKIADAGHNHSISLNIENNIMLV-GDKNRLSQLFTNVVSNAIKHSADNTKILISA 297
Cdd:COG0642 170 LEAGKLELEPEPVDLAELLEEVVELFRPLAEEKGIELELDLPDDLPTVrGDPDRLRQVLLNLLSNAIKYTPEGGTVTVSV 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447491076 298 KSNHEKNILVcnVINFGTQIPEENRADIFRRFVKGNQgmGTESGGTGLGLSIARWAALLHHGNIRVVDDK-RGVNFEITL 376
Cdd:COG0642 250 RREGDRVRIS--VEDTGPGIPPEDLERIFEPFFRTDP--SRRGGGTGLGLAIVKRIVELHGGTIEVESEPgKGTTFTVTL 325
|
...
gi 1447491076 377 PLT 379
Cdd:COG0642 326 PLA 328
|
|
| BaeS_SmeS |
NF012163 |
sensor histidine kinase efflux regulator BaeS; |
85-377 |
4.34e-49 |
|
sensor histidine kinase efflux regulator BaeS;
Pssm-ID: 411086 [Multi-domain] Cd Length: 457 Bit Score: 171.93 E-value: 4.34e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447491076 85 WIAMPLTLAVALGITYAFSRGLTSPLRQMRDAAETMADGDYSVRVQIeSRKDEVGKLTLAFNEMAEELEHADNMRRDLIA 164
Cdd:NF012163 167 WLIVALALLLAALAAFLLARGLLAPVKRLVEATHRLAAGDYTTRVTP-TSNDELGKLAQDFNQLASTLEKNEQMRRDFMA 245
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447491076 165 NVSHELRTPVSALQAMVENLADGVVEPTPSNMEAIVNQTHKLADLITFLLDLSRVEAGAESLVITSFDFKDFINNIVETV 244
Cdd:NF012163 246 DISHELRTPLAVLRAELEAIQDGIRKFTPESLDSLQAEVGTLTKLVDDLHDLSMSDEGALAYQKASVDLVPLLEVEGGAF 325
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447491076 245 KIADAGHNHSISLNIENNIMLVGDKNRLSQLFTNVVSNAIKHSADNTKILISAKSNHEKNILVCNVINFGtqIPEENRAD 324
Cdd:NF012163 326 RERFASAGLELEVSLPDSSLVFGDRDRLMQLFNNLLENSLRYTDSGGSLHISASQRPKEVTLTVADSAPG--VSDEQLAR 403
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 1447491076 325 IFRRFVKGNQGMGTESGGTGLGLSIARWAALLHHGNIRVVDDK-RGVNFEITLP 377
Cdd:NF012163 404 LFERFYRVEVSRNRASGGSGLGLAISLNIVQAHGGTLHAAHSPlGGLRIVVTLP 457
|
|
| PRK10549 |
PRK10549 |
two-component system sensor histidine kinase BaeS; |
85-378 |
1.27e-47 |
|
two-component system sensor histidine kinase BaeS;
Pssm-ID: 182539 [Multi-domain] Cd Length: 466 Bit Score: 168.27 E-value: 1.27e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447491076 85 WIAMPLTLAVALGITYAFSRGLTSPLRQMRDAAETMADGDYSVRVQIESRkDEVGKLTLAFNEMAEELEHADNMRRDLIA 164
Cdd:PRK10549 167 WLIVALSTLLAALATFLLARGLLAPVKRLVEGTHKLAAGDFTTRVTPTSR-DELGRLAQDFNQLASTLEKNEQMRRDFMA 245
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447491076 165 NVSHELRTPVSALQAMVENLADGVVEPTPSNMEAIVNQTHKLADLITFLLDLSRVEAGAESLVitsfdfKDFInNIVETV 244
Cdd:PRK10549 246 DISHELRTPLAVLRGELEAIQDGVRKFTPESVASLQAEVGTLTKLVDDLHQLSLSDEGALAYR------KTPV-DLVPLL 318
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447491076 245 KIADAGHNH-------SISLNIENNIMLVGDKNRLSQLFTNVVSNAIKHSADNTKILISAKSNHEKNILvcnviNFGTQI 317
Cdd:PRK10549 319 EVAGGAFRErfasrglTLQLSLPDSATVFGDPDRLMQLFNNLLENSLRYTDSGGSLHISAEQRDKTLRL-----TFADSA 393
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1447491076 318 P---EENRADIFRRFVKGNQGMGTESGGTGLGLSIARWAALLHHGNIRVV-DDKRGVNFEITLPL 378
Cdd:PRK10549 394 PgvsDEQLQKLFERFYRTEGSRNRASGGSGLGLAICLNIVEAHNGRIIAAhSPFGGVSITVELPL 458
|
|
| phoR_proteo |
TIGR02966 |
phosphate regulon sensor kinase PhoR; Members of this protein family are the regulatory ... |
151-363 |
4.04e-43 |
|
phosphate regulon sensor kinase PhoR; Members of this protein family are the regulatory histidine kinase PhoR associated with the phosphate ABC transporter in most Proteobacteria. Related proteins from Gram-positive organisms are not included in this model. The phoR gene usually is adjacent to the response regulator phoB gene (TIGR02154). [Signal transduction, Two-component systems]
Pssm-ID: 274368 [Multi-domain] Cd Length: 333 Bit Score: 152.75 E-value: 4.04e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447491076 151 ELEHADNMRRDLIANVSHELRTPVSALQAMVENLADGVVEPTPSN---MEAIVNQTHKLADLITFLLDLSRVEAGAESLV 227
Cdd:TIGR02966 106 RLRRLEQMRRDFVANVSHELRTPLTVLRGYLETLADGPDEDPEEWnraLEIMLEQSQRMQSLVEDLLTLSRLESAASPLE 185
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447491076 228 ITSFDFKDFINNIVETVKIADAGHNHSISLNIENNIMLVGDKNRLSQLFTNVVSNAIKHSADNTKILISAKsnHEKNILV 307
Cdd:TIGR02966 186 DEPVDMPALLDHLRDEAEALSQGKNHQITFEIDGGVDVLGDEDELRSAFSNLVSNAIKYTPEGGTITVRWR--RDGGGAE 263
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 1447491076 308 CNVINFGTQIPEENRADIFRRFVKGNQGMGTESGGTGLGLSIARWAALLHHGNIRV 363
Cdd:TIGR02966 264 FSVTDTGIGIAPEHLPRLTERFYRVDKSRSRDTGGTGLGLAIVKHVLSRHHARLEI 319
|
|
| NtrY |
COG5000 |
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ... |
90-379 |
1.46e-35 |
|
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];
Pssm-ID: 444024 [Multi-domain] Cd Length: 422 Bit Score: 134.70 E-value: 1.46e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447491076 90 LTLAVALGITYAFSRGLTSPLRQMRDAAETMADGDYSVRVQIESRkDEVGKLTLAFNEMAEELEHA-------------- 155
Cdd:COG5000 17 LLLLLALWLALLLARRLTRPLRRLAEATRAVAAGDLSVRLPVTGD-DEIGELARAFNRMTDQLKEQreeleerrryleti 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447491076 --------------------------------------------------------------------------------
Cdd:COG5000 96 lenlpagvivldadgritlanpaaerllgipleeligkpleellpeldlaellrealergwqeeieltrdgrrtllvras 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447491076 156 -----------DNMRR-----------DLIANVSHELRTPVSALQAMVENLADGVVEPTPSNMEA-------IVNQTHKL 206
Cdd:COG5000 176 plrddgyvivfDDITEllraerlaawgELARRIAHEIKNPLTPIQLSAERLRRKLADKLEEDREDleraldtIIRQVDRL 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447491076 207 ADLITFLLDLSRVEAgaesLVITSFDFKDFINNIVETVKIADAGHNHSISLNIENNIMLV-GDKNRLSQLFTNVVSNAIK 285
Cdd:COG5000 256 KRIVDEFLDFARLPE----PQLEPVDLNELLREVLALYEPALKEKDIRLELDLDPDLPEVlADRDQLEQVLINLLKNAIE 331
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447491076 286 HSADNTKILISAKSNHEKNILVcnVINFGTQIPEENRADIFRRFVKgnqgmgTESGGTGLGLSIARWAALLHHGNIRVVD 365
Cdd:COG5000 332 AIEEGGEIEVSTRREDGRVRIE--VSDNGPGIPEEVLERIFEPFFT------TKPKGTGLGLAIVKKIVEEHGGTIELES 403
|
410
....*....|....*
gi 1447491076 366 DK-RGVNFEITLPLT 379
Cdd:COG5000 404 RPgGGTTFTIRLPLA 418
|
|
| AdeS_HK |
NF012226 |
two-component sensor histidine kinase AdeS; Mutations in this component of the two-component ... |
67-378 |
1.16e-32 |
|
two-component sensor histidine kinase AdeS; Mutations in this component of the two-component regulatory system for the AdeABC efflux pump can confer adaptive resistance to certain antibiotics, including tigecycline.
Pssm-ID: 411090 [Multi-domain] Cd Length: 353 Bit Score: 125.49 E-value: 1.16e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447491076 67 TAIAFVMAWFLLKVGLSGWIampltLAVALGITYAfsRGLTSPLRQMRDAAETMADGDYSVRV---QIESRkdEVGKLTL 143
Cdd:NF012226 52 TEFHFVDWIWLFTVILCGSV-----ISLIIGMKLA--QRFIVPINFLADAAKKISQGDLSARAedsQIHSA--EISELMH 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447491076 144 AFNEMAEELEHADNMRRDLIANVSHELRTPVSALQAMVENLADGVVEPTPSNMEAIVNQTHKLADLITFLLDLSRVEAGA 223
Cdd:NF012226 123 NFNDMAQKLESSVKNAQVWNAAIAHELRTPITILQGRLQGILDGVFEPDPALFKSLLNQVEGLSHLVEDLRTLSLVENQQ 202
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447491076 224 ESLVITSFDFKDFINNIVETV--KIADAGHNhsISLNIENNIMLVgDKNRLSQLFTNVVSNAIKHsADNTKILISAKSNH 301
Cdd:NF012226 203 LRLNYESVDLKDSIEKVLKMFedRLEQAQLT--IVLNLTATPVFC-DRRRIEQVLIALIDNAIRY-ANAGKLKISSSVIQ 278
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1447491076 302 EKNILvcNVINFGTQIPEENRADIFRRFVKGNQGMGTESGGTGLGLSIARWAALLHHGNIRVVDDKRGVNFEITLPL 378
Cdd:NF012226 279 DDWIL--QIEDEGPGIAEEYQQDLFNPFFRLEQSRNKEFGGTGLGLAVVHAIVIAHKGSIEYSNSQGNSVFTIKLPA 353
|
|
| HK_WalK |
NF033092 |
cell wall metabolism sensor histidine kinase WalK; This model describes WalK as found in ... |
86-378 |
2.29e-31 |
|
cell wall metabolism sensor histidine kinase WalK; This model describes WalK as found in Staphylococcus aureus (sp|Q2G2U4.1|WALK_STAA8). A shorter version, as found in Streptococcus pneumoniae, called WalK(Spn) or VicK, is not included. WalK is part of a two-component system and works with partner protein WalR.
Pssm-ID: 467964 [Multi-domain] Cd Length: 594 Bit Score: 125.25 E-value: 2.29e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447491076 86 IAMPLTLAVALGItyafSRGLTSPLRQMRDAAETMADGDYSVRVQIESrKDEVGKLTLAFNEMAEELEHA---------- 155
Cdd:NF033092 185 IALVITAVLGILL----ARTITRPIKEMRKQALAMAKGDFSRKVKVYG-NDEIGQLAEAFNNLTKRLQEAqatteserrk 259
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447491076 156 -----DNM------------------------------------------------------------------------ 158
Cdd:NF033092 260 ldsvlSHMtdgviatdrrgrvilindpalemlnvsretvlgqsildvlgleeeytlrdlleeqdsllldfsteeeplilr 339
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447491076 159 --------------------------------RRDLIANVSHELRTPVSALQAMVENLADGVVE-PT--PSNMEAIVNQT 203
Cdd:NF033092 340 anfsviqresgfingliavlhdvteqekieqeRREFVANVSHELRTPLTTMRSYLEALADGAWKdPElaPRFLGVTQNET 419
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447491076 204 HKLADLITFLLDLSRVEAGAESLVITSFDFKDFINNIVETVKIADAGHNHSISLNIENNIMLV-GDKNRLSQLFTNVVSN 282
Cdd:NF033092 420 ERMIRLVNDLLQLSRMDSKDYKLNKEWVNFNEFFNYIIDRFEMILKNKNITFKREFPKRDLWVeIDTDKITQVLDNIISN 499
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447491076 283 AIKHSADNTKILISAKSNHekNILVCNVINFGTQIPEENRADIFRRFVKGNQGMGTESGGTGLGLSIARWAALLHHGNIR 362
Cdd:NF033092 500 AIKYSPEGGTITFRLLETH--NRIIISISDQGLGIPKKDLDKIFDRFYRVDKARSRKMGGTGLGLAIAKEVVEAHGGRIW 577
|
410
....*....|....*...
gi 1447491076 363 V--VDDKrGVNFEITLPL 378
Cdd:NF033092 578 AesEEGK-GTTIYFTLPY 594
|
|
| MtrAB_MtrB |
NF040691 |
MtrAB system histidine kinase MtrB; |
90-379 |
1.36e-29 |
|
MtrAB system histidine kinase MtrB;
Pssm-ID: 468655 [Multi-domain] Cd Length: 507 Bit Score: 119.36 E-value: 1.36e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447491076 90 LTLAVALG-ITYAFSRGLTSPLRQMRDAAETMADGDYSVRVQIESrKDEVGKLTLAFNEMAE-------ELEHADNMRRD 161
Cdd:NF040691 195 LALVVLLGlIAWLVTRQVVAPVRSAARTAERFAAGDLSERMPVKG-EDDLARLARSFNQMADslqrqirQLEELSRLQQR 273
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447491076 162 LIANVSHELRTPVSALQAMVENLADGVVEPTPS---NMEAIVNQTHKLADLITFLLDLSRVEAGAESLVITSFDFKDFIN 238
Cdd:NF040691 274 FVSDVSHELRTPLTTIRMAADVIHDSRDDFDPAtarSAELLHTELDRFESLLSDLLEISRFDAGAAELDVEPVDLRPLVR 353
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447491076 239 NIVETVKIADAGHNHSISLNI-ENNIMLVGDKNRLSQLFTNVVSNAIKHsADNTKILISAKSNHEKNILVcnVINFGTQI 317
Cdd:NF040691 354 RVVDALRQLAERAGVELRVDApGTPVVAEVDPRRVERVLRNLVVNAIEH-GEGKPVVVTVAQDDTAVAVT--VRDHGVGL 430
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1447491076 318 PEENRADIFRRFVKGNQGMGTESGGTGLGLSIARWAALLHHGNIRVVDDK-RGVNFEITLPLT 379
Cdd:NF040691 431 KPGEVALVFDRFWRADPARARTTGGTGLGLAIALEDARLHGGWLEAWGRPgQGSQFRLTLPRV 493
|
|
| cztS_silS_copS |
TIGR01386 |
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ... |
56-377 |
4.10e-29 |
|
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.
Pssm-ID: 273593 [Multi-domain] Cd Length: 457 Bit Score: 117.49 E-value: 4.10e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447491076 56 KGELSAIIVFATAIAF---VMAWFLLKVGLSGWIAMPLTLAVALGITyafSRGLtSPLRQMRDAAETMADGDYSVRVQIE 132
Cdd:TIGR01386 139 KGRKPVQITVALDINAhthLLDALRKWLILIAVLLVLLTALLGWWIT---RLGL-EPLRRLSAVAARISPESLDQRLDPS 214
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447491076 133 SRKDEVGKLTLAFNEMAEELEHADNMRRDLIANVSHELRTPVSAL--QAMV----ENLADGVVEPTPSNMEaivnQTHKL 206
Cdd:TIGR01386 215 RAPAELRELAQSFNAMLGRLEDAFQRLSQFSADLAHELRTPLTNLlgQTQValsqPRTGEEYREVLESNLE----ELERL 290
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447491076 207 ADLITFLLDLSRVEAGAESLVITSFDFKDFINNIVETVK-IADaghNHSISLNIENNIMLVGDKNRLSQLFTNVVSNAIK 285
Cdd:TIGR01386 291 SRMVSDMLFLARADNGQLALERVRLDLAAELAKVAEYFEpLAE---ERGVRIRVEGEGLVRGDPQMFRRAISNLLSNALR 367
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447491076 286 HSADNTKILIS-AKSNHEKNILVCNVinfGTQIPEENRADIFRRFVKGNQGMGTESGGTGLGLSIARWAALLHHGNIRVV 364
Cdd:TIGR01386 368 HTPDGGTITVRiERRSDEVRVSVSNP---GPGIPPEHLSRLFDRFYRVDPARSNSGEGTGLGLAIVRSIMEAHGGRASAE 444
|
330
....*....|...
gi 1447491076 365 DDKRGVNFEITLP 377
Cdd:TIGR01386 445 SPDGKTRFILRFP 457
|
|
| COG4251 |
COG4251 |
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ... |
127-377 |
2.52e-28 |
|
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];
Pssm-ID: 443393 [Multi-domain] Cd Length: 503 Bit Score: 115.65 E-value: 2.52e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447491076 127 VRVQIESRKDEVGKLTLAFNEMAEELEHAdNMRRDLIAN-VSHELRTP----VSALQAMVENLADGVVEPTPSNMEAIVN 201
Cdd:COG4251 250 LVLELLELRLELEELEEELEERTAELERS-NEELEQFAYvASHDLREPlrkiSGFSQLLEEDYGDKLDEEGREYLERIRD 328
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447491076 202 QTHKLADLITFLLDLSRVeaGAESLVITSFDFKDFINNIVETVKIADAGHNhsISLNIENNIMLVGDKNRLSQLFTNVVS 281
Cdd:COG4251 329 AAERMQALIDDLLAYSRV--GRQELEFEPVDLNELLEEVLEDLEPRIEERG--AEIEVGPLPTVRGDPTLLRQVFQNLIS 404
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447491076 282 NAIKHSADNT--KILISAKSNHEKNILVC--NvinfGTQIPEENRADIFRRFVKGNQgmGTESGGTGLGLSIARWAALLH 357
Cdd:COG4251 405 NAIKYSRPGEppRIEIGAEREGGEWVFSVrdN----GIGIDPEYAEKIFEIFQRLHS--RDEYEGTGIGLAIVKKIVERH 478
|
250 260
....*....|....*....|.
gi 1447491076 358 HGNIRVVDDK-RGVNFEITLP 377
Cdd:COG4251 479 GGRIWVESEPgEGATFYFTLP 499
|
|
| marine_sort_HK |
TIGR03785 |
proteobacterial dedicated sortase system histidine kinase; This histidine kinase protein is ... |
92-377 |
1.26e-27 |
|
proteobacterial dedicated sortase system histidine kinase; This histidine kinase protein is paired with an adjacent response regulator (TIGR03787) gene. It co-occurs with a variant sortase enzyme (TIGR03784), usually in the same gene neighborhood, in proteobacterial species most of which are marine, and with an LPXTG motif-containing sortase target conserved protein (TIGR03788). Sortases and LPXTG proteins are far more common in Gram-positive bacteria, where sortase systems mediate attachment to the cell wall or cross-linking of pilin structures. We give this predicted sensor histidine kinase the gene symbol psdS, for Proteobacterial Dedicated Sortase system Sensor histidine kinase.
Pssm-ID: 163497 [Multi-domain] Cd Length: 703 Bit Score: 114.46 E-value: 1.26e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447491076 92 LAVALGITYA---FSRGLTSPLRQMRDAAETMAD--GDYSVRVQIESRKDEVGKLTLAFNEMAEELEHADNMRRDLIANV 166
Cdd:TIGR03785 413 LAIMSIGTLAlfgFASWISWRIRRLSDDAEAAIDsqGRISGAIPASRSRDEIGDLSRSFAQMVARLRQYTHYLENMSSRL 492
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447491076 167 SHELRTPVSALQAMVENLADGVVEP-TPSNMEAIVNQTHKLADLITFLLDLSRVEAGAESLVITSFDFKDFINNIVETVK 245
Cdd:TIGR03785 493 SHELRTPVAVVRSSLENLELQALEQeKQKYLERAREGTERLSMILNNMSEATRLEQAIQSAEVEDFDLSEVLSGCMQGYQ 572
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447491076 246 IADAGHNhsISLNI-ENNIMLVGDKNRLSQLFTNVVSNAIKHSADNTKILISAKSNHEKNILVcnVINFGTQIPEENRAD 324
Cdd:TIGR03785 573 MTYPPQR--FELNIpETPLVMRGSPELIAQMLDKLVDNAREFSPEDGLIEVGLSQNKSHALLT--VSNEGPPLPEDMGEQ 648
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*
gi 1447491076 325 IFRRFVKGNQGMGTESGGTGLGLSIARWAALLHHGNIRVVD--DKRGVNFEITLP 377
Cdd:TIGR03785 649 LFDSMVSVRDQGAQDQPHLGLGLYIVRLIADFHQGRIQAENrqQNDGVVFRISLP 703
|
|
| envZ |
PRK09467 |
osmolarity sensor protein; Provisional |
85-379 |
5.63e-26 |
|
osmolarity sensor protein; Provisional
Pssm-ID: 236531 [Multi-domain] Cd Length: 435 Bit Score: 108.07 E-value: 5.63e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447491076 85 WIAMPLT-------------------LAVALGitYAFSRGLTSPLRQMRDAAETMADGDYSVRVqIESRKDEVGKLTLAF 145
Cdd:PRK09467 139 WVRVPLTeihqgdfsplfrytlaiglLSVAGG--WLFIRIQNRPLVALEHAALQVGKGEIPPPL-REYGASEVRSVTRAF 215
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447491076 146 NEMAEELEHADNMRRDLIANVSHELRTPVS----ALQAMVEN---LADGVVEPTpSNMEAIVNQthkladlitfLLDLSR 218
Cdd:PRK09467 216 NQMAAGIKQLEDDRTLLMAGVSHDLRTPLTrirlATEMMSEEdgyLAESINKDI-EECNAIIEQ----------FIDYLR 284
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447491076 219 veAGAESlvitSFDFKDfINNIVETVKIADAGHNHSISLNIeNNIMLVGDKNRLS--QLFTNVVSNAIKHSADNTKILis 296
Cdd:PRK09467 285 --TGQEM----PMEMAD-LNALLGEVIAAESGYEREIETAL-QPGPIEVPMNPIAikRALANLVVNAARYGNGWIKVS-- 354
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447491076 297 akSNHEKNILVCNVINFGTQIPEENRADIFRRFVKGNQGMGTEsgGTGLGLSIARWAALLHHGNIRVVDDKR-GVNFEIT 375
Cdd:PRK09467 355 --SGTEGKRAWFQVEDDGPGIPPEQLKHLFQPFTRGDSARGSS--GTGLGLAIVKRIVDQHNGKVELGNSEEgGLSARAW 430
|
....
gi 1447491076 376 LPLT 379
Cdd:PRK09467 431 LPLT 434
|
|
| cpxA |
PRK09470 |
envelope stress sensor histidine kinase CpxA; |
103-378 |
2.54e-25 |
|
envelope stress sensor histidine kinase CpxA;
Pssm-ID: 236532 [Multi-domain] Cd Length: 461 Bit Score: 106.55 E-value: 2.54e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447491076 103 SRGLTSPLRQMRDAAETMADGDYSVRVQIESRKDEVGKLTLAFNEMAEELEHADNMRRDLIANVSHELRTPVSALQaMVE 182
Cdd:PRK09470 187 AWSLAKPARKLKNAADEVAQGNLRQHPELETGPQEFRQAGASFNQMVTALERMMTSQQRLLSDISHELRTPLTRLQ-LAT 265
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447491076 183 NLA-----DGvveptpSNMEAIVNQTHKLADLITFLLDLSRVEAGAEsLVITSFDFKDFINNIVETVKIaDAGHNHsISL 257
Cdd:PRK09470 266 ALLrrrqgES------KELERIETEAQRLDSMINDLLVLSRNQQKNH-LERETFKANSLWSEVLEDAKF-EAEQMG-KSL 336
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447491076 258 NIE---NNIMLVGDKNRLSQLFTNVVSNAIKHSADNTKILISAKsnheKNILVCNVINFGTQIPEENRADIFRRFVKGNQ 334
Cdd:PRK09470 337 TVSappGPWPINGNPNALASALENIVRNALRYSHTKIEVAFSVD----KDGLTITVDDDGPGVPEEEREQIFRPFYRVDE 412
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 1447491076 335 GMGTESGGTGLGLSIARWAALLHHGNIRVVD-DKRGVNFEITLPL 378
Cdd:PRK09470 413 ARDRESGGTGLGLAIVENAIQQHRGWVKAEDsPLGGLRLTIWLPL 457
|
|
| phoR |
PRK11006 |
phosphate regulon sensor histidine kinase PhoR; |
156-377 |
2.57e-25 |
|
phosphate regulon sensor histidine kinase PhoR;
Pssm-ID: 182895 [Multi-domain] Cd Length: 430 Bit Score: 106.25 E-value: 2.57e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447491076 156 DNMRRDLIANVSHELRTPVSALQAMVENLADGVVEpTPSNMEAI---VNQTHKLADLITFLLDLSRVEAGAESLVITSFD 232
Cdd:PRK11006 201 EGARRNFFANVSHELRTPLTVLQGYLEMMQDQPLE-GALREKALhtmREQTQRMEGLVKQLLTLSKIEAAPTIDLNEKVD 279
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447491076 233 FKDFInNIVETVKIADAGHNHSISLNIENNIMLVGDKNRLSQLFTNVVSNAIKHSADNTKILISAKSNHEKNILvcNVIN 312
Cdd:PRK11006 280 VPMML-RVLEREAQTLSQGKHTITFEVDNSLKVFGNEDQLRSAISNLVYNAVNHTPEGTHITVRWQRVPQGAEF--SVED 356
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1447491076 313 FGTQIPEENRADIFRRFVKGNQGMGTESGGTGLGLSIARwAALLHHGNIRVVDDKRGVN--FEITLP 377
Cdd:PRK11006 357 NGPGIAPEHIPRLTERFYRVDKARSRQTGGSGLGLAIVK-HALSHHDSRLEIESEVGKGtrFSFVLP 422
|
|
| PRK11100 |
PRK11100 |
sensory histidine kinase CreC; Provisional |
79-378 |
6.94e-25 |
|
sensory histidine kinase CreC; Provisional
Pssm-ID: 236846 [Multi-domain] Cd Length: 475 Bit Score: 105.31 E-value: 6.94e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447491076 79 KVGLSGWIAMPLTLAVALGITYAfsrgLTSPLRQMRDAAETMADGDysvRVQI-ESRKDEVGKLTLAFNEMAEELEHadn 157
Cdd:PRK11100 183 RILWAGALLLGIALLIGAGVVWW----LNRSIRRLTRYADAVTEGK---PVPLpKLGSSELRELAQALESMRVKLEG--- 252
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447491076 158 mrRDLIANV----SHELRTPVSALQAMVENLADgvvEPTPSNME----AIVNQTHKLADLITFLLDLSRVEAGAESLVIT 229
Cdd:PRK11100 253 --KAYVEQYvqtlTHELKSPLAAIRGAAELLQE---DPPPEDRArftgNILTQSARLQQLIDRLLELARLEQRQELEVLE 327
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447491076 230 SFDFKDFINNIVETVKIADAGHNHSISLNIENnIMLVGDKNRLSQLFTNVVSNAIKHSADNTKILISAKSNHEKNILVcn 309
Cdd:PRK11100 328 PVALAALLEELVEAREAQAAAKGITLRLRPDD-ARVLGDPFLLRQALGNLLDNAIDFSPEGGTITLSAEVDGEQVALS-- 404
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1447491076 310 VINFGTQIPEENRADIFRRF---VKGNQGmgteSGGTGLGLSIARWAALLHHGNIRVVD-DKRGVNFEITLPL 378
Cdd:PRK11100 405 VEDQGPGIPDYALPRIFERFyslPRPANG----RKSTGLGLAFVREVARLHGGEVTLRNrPEGGVLATLTLPR 473
|
|
| PRK10604 |
PRK10604 |
sensor protein RstB; Provisional |
77-363 |
1.67e-24 |
|
sensor protein RstB; Provisional
Pssm-ID: 236724 [Multi-domain] Cd Length: 433 Bit Score: 103.91 E-value: 1.67e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447491076 77 LLKVGLSGWIAMPLTLAVALGItyafsRGLTSPLRQMRDAAETMADGDYSVRVQIESrKDEVGKLTLAFNEMAEELEHAD 156
Cdd:PRK10604 136 LLDIALLALIGLSLAFPVFLWM-----RPHWQDMLKLEAAAQRLGDGHLAERIHFDE-GSSLERLGVAFNQMADNINALI 209
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447491076 157 NMRRDLIANVSHELRTPVSALQ---AMVENLadgvvepTPSNMEAIVNQTHKLADLITFLLDLSRVEAGAESLVITSFDF 233
Cdd:PRK10604 210 ASKKQLIDGIAHELRTPLVRLRyrlEMSDNL-------SAAESQALNRDIGQLEALIEELLTYARLDRPQNELHLSEPDL 282
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447491076 234 KDFINNIVETVKIADAGHNHSISLNIENNImLVGDKNRLSQLFTNVVSNAIKHSADNTKILISAKSNHeknilVC-NVIN 312
Cdd:PRK10604 283 PAWLSTHLADIQAVTPEKTVRLDTPHQGDY-GALDMRLMERVLDNLLNNALRYAHSRVRVSLLLDGNQ-----AClIVED 356
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 1447491076 313 FGTQIPEENRADIFRRFVKGNQGMGTESGGTGLGLSIARWAALLHHGNIRV 363
Cdd:PRK10604 357 DGPGIPPEERERVFEPFVRLDPSRDRATGGCGLGLAIVHSIALAMGGSVNC 407
|
|
| NtrB |
COG3852 |
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms]; |
147-379 |
7.81e-24 |
|
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
Pssm-ID: 443061 [Multi-domain] Cd Length: 361 Bit Score: 101.08 E-value: 7.81e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447491076 147 EMAEELEHADNMR--RDLIANVSHELRTPVS----ALQAMVENLADgvvEPTPSNMEAIVNQTHKLADLITFLLDLSRVE 220
Cdd:COG3852 121 RLERELRRAEKLAavGELAAGLAHEIRNPLTgirgAAQLLERELPD---DELREYTQLIIEEADRLNNLVDRLLSFSRPR 197
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447491076 221 AGAESLVitsfDFKDFINNIVETVKiADAGHNHSISLNIENNI-MLVGDKNRLSQLFTNVVSNAIKHSADNTKILISAKS 299
Cdd:COG3852 198 PPEREPV----NLHEVLERVLELLR-AEAPKNIRIVRDYDPSLpEVLGDPDQLIQVLLNLVRNAAEAMPEGGTITIRTRV 272
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447491076 300 NHEKNI--------LVCNVINFGTQIPEENRADIFRRFV--KGNqgmgtesgGTGLGLSIARWAALLHHGNIRVV-DDKR 368
Cdd:COG3852 273 ERQVTLgglrprlyVRIEVIDNGPGIPEEILDRIFEPFFttKEK--------GTGLGLAIVQKIVEQHGGTIEVEsEPGK 344
|
250
....*....|.
gi 1447491076 369 GVNFEITLPLT 379
Cdd:COG3852 345 GTTFRIYLPLE 355
|
|
| COG4191 |
COG4191 |
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ... |
57-379 |
8.14e-24 |
|
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];
Pssm-ID: 443345 [Multi-domain] Cd Length: 361 Bit Score: 101.03 E-value: 8.14e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447491076 57 GELSAIIVFATAIAFVMAWFLLKVGLSGWIAMPLTLAVALGITYAFSRGLTSPLRQMRDAAETMADGDYSVRVQIESRKD 136
Cdd:COG4191 35 LLLLLLALLLALLALLLLLLLLLLLLLLELLLLLLALLGGLLRLLLLLGLLLLLLLEALLLLLLAALDAEENAELEELER 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447491076 137 EVGKLTLAFNE---MAEELEHADNMR--RDLIANVSHELRTPVSALQAMVENLADGV-----VEPTPSNMEAIVNQTHKL 206
Cdd:COG4191 115 DITELERAEEElreLQEQLVQSEKLAalGELAAGIAHEINNPLAAILGNAELLRRRLedepdPEELREALERILEGAERA 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447491076 207 ADLITFLLDLSRveagAESLVITSFDFKDFINNIVETVKIADAGHNHSISLNIENNIMLV-GDKNRLSQLFTNVVSNAI- 284
Cdd:COG4191 195 AEIVRSLRAFSR----RDEEEREPVDLNELIDEALELLRPRLKARGIEVELDLPPDLPPVlGDPGQLEQVLLNLLINAId 270
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447491076 285 --KHSADNTkILISAKSnHEKNILVCnVINFGTQIPEENRADIFRRFV--KGnqgmgtESGGTGLGLSIARWAALLHHGN 360
Cdd:COG4191 271 amEEGEGGR-ITISTRR-EGDYVVIS-VRDNGPGIPPEVLERIFEPFFttKP------VGKGTGLGLSISYGIVEKHGGR 341
|
330 340
....*....|....*....|
gi 1447491076 361 IRVVDDK-RGVNFEITLPLT 379
Cdd:COG4191 342 IEVESEPgGGTTFTITLPLA 361
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
267-379 |
1.93e-23 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 93.87 E-value: 1.93e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447491076 267 GDKNRLSQLFTNVVSNAIKHSADNTKILISAKSNHEKNILVcnVINFGTQIPEENRADIFRRFVKGNQGMgTESGGTGLG 346
Cdd:smart00387 1 GDPDRLRQVLSNLLDNAIKYTPEGGRITVTLERDGDHVEIT--VEDNGPGIPPEDLEKIFEPFFRTDKRS-RKIGGTGLG 77
|
90 100 110
....*....|....*....|....*....|....
gi 1447491076 347 LSIARWAALLHHGNIRVVDD-KRGVNFEITLPLT 379
Cdd:smart00387 78 LSIVKKLVELHGGEISVESEpGGGTTFTITLPLE 111
|
|
| TMAO_torS |
TIGR02956 |
TMAO reductase sytem sensor TorS; This protein, TorS, is part of a regulatory system for the ... |
130-382 |
4.05e-23 |
|
TMAO reductase sytem sensor TorS; This protein, TorS, is part of a regulatory system for the torCAD operon that encodes the pterin molybdenum cofactor-containing enzyme trimethylamine-N-oxide (TMAO) reductase (TorA), a cognate chaperone (TorD), and a penta-haem cytochrome (TorC). TorS works together with the inducer-binding protein TorT and the response regulator TorR. TorS contains histidine kinase ATPase (pfam02518), HAMP (pfam00672), phosphoacceptor (pfam00512), and phosphotransfer (pfam01627) domains and a response regulator receiver domain (pfam00072). [Signal transduction, Two-component systems]
Pssm-ID: 274362 [Multi-domain] Cd Length: 968 Bit Score: 101.39 E-value: 4.05e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447491076 130 QIESRKDEVGKLTLAFNEMA-------EELEHADNMRRDLIANVSHELRTPVSALQAMVENLADGVVEPTPSNMEAIVNQ 202
Cdd:TIGR02956 428 LVAQRTQELAETNERLNAEVknhakarAEAEEANRAKSAFLATMSHEIRTPLNGILGTLELLGDTGLTSQQQQYLQVINR 507
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447491076 203 T-HKLADLITFLLDLSRVEAGAESLVITSFDFKDFINNIVETVKiADAGHNH-SISLNIENNI--MLVGDKNRLSQLFTN 278
Cdd:TIGR02956 508 SgESLLDILNDILDYSKIEAGHLSISPRPFDLNALLDDVHHLMV-SRAQLKGiQLRLNIPEQLpnWWQGDGPRIRQVLIN 586
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447491076 279 VVSNAIKHSaDNTKILISAKSNHEKNILVcNVINFGTQIPEENRADIFRRFVKGnQGMGTeSGGTGLGLSIARWAALLHH 358
Cdd:TIGR02956 587 LVGNAIKFT-DRGSVVLRVSLNDDSSLLF-EVEDTGCGIAEEEQATLFDAFTQA-DGRRR-SGGTGLGLAISQRLVEAMD 662
|
250 260
....*....|....*....|....*
gi 1447491076 359 GNIRVVDDK-RGVNFEITLPLTYSE 382
Cdd:TIGR02956 663 GELGVESELgVGSCFWFTLPLTRGK 687
|
|
| KinE |
COG5809 |
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ... |
147-382 |
1.01e-22 |
|
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444511 [Multi-domain] Cd Length: 489 Bit Score: 99.28 E-value: 1.01e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447491076 147 EMAEELEHAD--NMRRDLIANVSHELRTPVSALQAMVENLADGVVEPTPSNMEAIVNQTHKLADLITFLLDLSRVEAGAe 224
Cdd:COG5809 256 KLEELLRKSEklSVVGELAAGIAHEIRNPLTSLKGFIQLLKDTIDEEQKTYLDIMLSELDRIESIISEFLVLAKPQAIK- 334
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447491076 225 slvITSFDFKDFINNIVETVKiADAGHNH-SISLNIENNI-MLVGDKNRLSQLFTNVVSNAIKHSADNTKILISAKSnHE 302
Cdd:COG5809 335 ---YEPKDLNTLIEEVIPLLQ-PQALLKNvQIELELEDDIpDILGDENQLKQVFINLLKNAIEAMPEGGNITIETKA-ED 409
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447491076 303 KNILVCNVINFGTQIPEENRADIFRRFVKgnqgmgTESGGTGLGLSIARWAALLHHGNIRVVDDK-RGVNFEITLPLTYS 381
Cdd:COG5809 410 DDKVVISVTDEGCGIPEERLKKLGEPFYT------TKEKGTGLGLMVSYKIIEEHGGKITVESEVgKGTTFSITLPIKLS 483
|
.
gi 1447491076 382 E 382
Cdd:COG5809 484 E 484
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
267-379 |
9.07e-21 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 86.27 E-value: 9.07e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447491076 267 GDKNRLSQLFTNVVSNAIKHSADNTKILISAksnHEKNILVCNVINFGTQIPEENRADIFRRFVkgnQGMGTESGGTGLG 346
Cdd:pfam02518 1 GDELRLRQVLSNLLDNALKHAAKAGEITVTL---SEGGELTLTVEDNGIGIPPEDLPRIFEPFS---TADKRGGGGTGLG 74
|
90 100 110
....*....|....*....|....*....|....
gi 1447491076 347 LSIARWAALLHHGNIRVVD-DKRGVNFEITLPLT 379
Cdd:pfam02518 75 LSIVRKLVELLGGTITVESePGGGTTVTLTLPLA 108
|
|
| PRK10490 |
PRK10490 |
sensor protein KdpD; Provisional |
140-378 |
1.46e-19 |
|
sensor protein KdpD; Provisional
Pssm-ID: 236701 [Multi-domain] Cd Length: 895 Bit Score: 90.48 E-value: 1.46e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447491076 140 KLTLAFNEMAEELE-HADNMRRDLIANVSHELRTPVSALQAMVENLA-DGVVEPTPSNMEA--IVNQTHKLADLITFLLD 215
Cdd:PRK10490 644 RLTLTASEEQARLAsEREQLRNALLAALSHDLRTPLTVLFGQAEILTlDLASEGSPHARQAseIRQQVLNTTRLVNNLLD 723
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447491076 216 LSRVEAGAESLVITSFDFKDFINNIVETVKIADAGHNhsISLNIENNIMLV-GDKNRLSQLFTNVVSNAIKHSADNTKIL 294
Cdd:PRK10490 724 MARIQSGGFNLRKEWLTLEEVVGSALQMLEPGLSGHP--INLSLPEPLTLIhVDGPLFERVLINLLENAVKYAGAQAEIG 801
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447491076 295 ISAKSnhEKNILVCNVINFGTQIPEENRADIFRRFVKGNQgmgtESG--GTGLGLSIARWAALLHHGNIRVVD-DKRGVN 371
Cdd:PRK10490 802 IDAHV--EGERLQLDVWDNGPGIPPGQEQLIFDKFARGNK----ESAipGVGLGLAICRAIVEVHGGTIWAENrPEGGAC 875
|
....*..
gi 1447491076 372 FEITLPL 378
Cdd:PRK10490 876 FRVTLPL 882
|
|
| PRK10755 |
PRK10755 |
two-component system sensor histidine kinase PmrB; |
94-379 |
1.52e-19 |
|
two-component system sensor histidine kinase PmrB;
Pssm-ID: 236751 [Multi-domain] Cd Length: 356 Bit Score: 88.87 E-value: 1.52e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447491076 94 VALGITYAFS----RGLTSPLRQMRDAAETMAdGDYSVRVQIESRKDEVGKLTLAFNEMAEELEHADNMRRDLIANVSHE 169
Cdd:PRK10755 69 VMVSLTLLICfqavRWITRPLAELQKELEART-ADNLTPIAIHSSTLEIEAVTSALNQLVSRLTSTLDQERLFTADVAHE 147
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447491076 170 LRTPVSALQAMVENLAD-GVVEPTPsnmeaIVNQTHKLADLITFLLDLSRVEagaESLVITSFDFKDFINNIV-----ET 243
Cdd:PRK10755 148 LRTPLAGIRLHLELLEKqHHIDVAP-----LIARLDQMMHTVEQLLQLARAG---QSFSSGHYQTVKLLEDVIlpsqdEL 219
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447491076 244 VKIADAGHNHSISLNIENNIMLVGDKNRLSQLFTNVVSNAIKHSADNTKILISAKSNHEKNILVcnVINFGTQIPEENRA 323
Cdd:PRK10755 220 SEMLEQRQQTLLLPESAADITVQGDATLLRLLLRNLVENAHRYSPEGSTITIKLSQEDGGAVLA--VEDEGPGIDESKCG 297
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 1447491076 324 DIFRRFVKgnqgMGTESGGTGLGLSIARWAALLHHGNIRVVD--DKRGVNFEITLPLT 379
Cdd:PRK10755 298 ELSKAFVR----MDSRYGGIGLGLSIVSRITQLHHGQFFLQNrqERSGTRAWVWLPKA 351
|
|
| PRK09835 |
PRK09835 |
Cu(+)/Ag(+) sensor histidine kinase; |
109-377 |
2.01e-18 |
|
Cu(+)/Ag(+) sensor histidine kinase;
Pssm-ID: 182101 [Multi-domain] Cd Length: 482 Bit Score: 86.36 E-value: 2.01e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447491076 109 PLRQMRDAAETMADGDYSVRVQIESRKDEVGKLTLAFNEMAEELEHADNMRRDLIANVSHELRTPVSAL---------QA 179
Cdd:PRK09835 212 PIRSVSRQIQNITSKDLDVRLDPQTVPIELEQLVLSFNHMIERIEDVFTRQSNFSADIAHEIRTPITNLitqteialsQS 291
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447491076 180 MVENLADGVVEptpSNMEAIVNQTHKLADLItFL-------LDLSRVEAGAESLVITSFDFKDfinnivetvkiADAGHN 252
Cdd:PRK09835 292 RSQKELEDVLY---SNLEELTRMAKMVSDML-FLaqadnnqLIPEKKMLDLADEVGKVFDFFE-----------AWAEER 356
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447491076 253 HsISLNIENNIMLV-GDKNRLSQLFTNVVSNAIKHSADNTKILISAkSNHEKNILVCnVINFGTQIPEENRADIFRRFVK 331
Cdd:PRK09835 357 G-VELRFVGDPCQVaGDPLMLRRAISNLLSNALRYTPAGEAITVRC-QEVDHQVQLV-VENPGTPIAPEHLPRLFDRFYR 433
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 1447491076 332 GNQGMGTESGGTGLGLSIARWAALLHHGNIRVVDDKRGVNFEITLP 377
Cdd:PRK09835 434 VDPSRQRKGEGSGIGLAIVKSIVVAHKGTVAVTSDARGTRFVISLP 479
|
|
| PRK15347 |
PRK15347 |
two component system sensor kinase; |
127-379 |
9.30e-18 |
|
two component system sensor kinase;
Pssm-ID: 237951 [Multi-domain] Cd Length: 921 Bit Score: 85.08 E-value: 9.30e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447491076 127 VRVQIESRKDEVGKLTLAFNEMAEELEHAdNMRRDL-IANVSHELRTPVSALQAMVENLadgvvEPTPSNmeaivNQTHK 205
Cdd:PRK15347 366 LNEQYDTLENKVAERTQALAEAKQRAEQA-NKRKSEhLTTISHEIRTPLNGVLGALELL-----QNTPLT-----AEQMD 434
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447491076 206 LAD-----------LITFLLDLSRVEAGAESLVITSFDFKDFINNIVETvkIADAGHNHSISL----NIENNIMLVGDKN 270
Cdd:PRK15347 435 LADtarqctlsllaIINNLLDFSRIESGQMTLSLEETALLPLLDQAMLT--IQGPAQSKSLTLrtfvGAHVPLYLHLDSL 512
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447491076 271 RLSQLFTNVVSNAIKHSADNtKILISAKsnHEKNILVCNVINFGTQIPEENRADIFRRFVKgnqgMGTESGGTGLGLSIA 350
Cdd:PRK15347 513 RLRQILVNLLGNAVKFTETG-GIRLRVK--RHEQQLCFTVEDTGCGIDIQQQQQIFTPFYQ----ADTHSQGTGLGLTIA 585
|
250 260 270
....*....|....*....|....*....|
gi 1447491076 351 RWAALLHHGNIRVVDD-KRGVNFEITLPLT 379
Cdd:PRK15347 586 SSLAKMMGGELTLFSTpGVGSCFSLVLPLN 615
|
|
| PRK11466 |
PRK11466 |
hybrid sensory histidine kinase TorS; Provisional |
77-378 |
4.26e-17 |
|
hybrid sensory histidine kinase TorS; Provisional
Pssm-ID: 236914 [Multi-domain] Cd Length: 914 Bit Score: 83.03 E-value: 4.26e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447491076 77 LLKVGLSGWIAMPLTLavaLGITYafsRGLTSPLRQMRDAAETMADGDY-------------------------SVRV-- 129
Cdd:PRK11466 333 LLLLGMVSLCALILIL---WRVVY---RSVTRPLAEQTQALQRLLDGDIdspfpetagvreldtigrlmdafrsNVHAln 406
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447491076 130 --------QIESRKDEVGKLTLAFNEMAEELEHADNMRRDLIANVSHELRTPVSALQAMVENLADGVVEPTPSN-MEAIV 200
Cdd:PRK11466 407 rhreqlaaQVKARTAELQELVIEHRQARAEAEKASQAKSAFLAAMSHEIRTPLYGILGTAQLLADNPALNAQRDdLRAIT 486
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447491076 201 NQTHKLADLITFLLDLSRVEAGAESLVITS--FDFKDFINNIVETVKIADAGHNHSISLNIENNI--MLVGDKNRLSQLF 276
Cdd:PRK11466 487 DSGESLLTILNDILDYSAIEAGGKNVSVSDepFEPRPLLESTLQLMSGRVKGRPIRLATDIADDLptALMGDPRRIRQVI 566
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447491076 277 TNVVSNAIKHSaDNTKILISAKSNHEKNILvcNVINFGTQIPEENRADIFRRFVKgnqgMGTESGGTGLGLSIARWAALL 356
Cdd:PRK11466 567 TNLLSNALRFT-DEGSIVLRSRTDGEQWLV--EVEDSGCGIDPAKLAEIFQPFVQ----VSGKRGGTGLGLTISSRLAQA 639
|
330 340
....*....|....*....|...
gi 1447491076 357 HHGNIRVVDD-KRGVNFEITLPL 378
Cdd:PRK11466 640 MGGELSATSTpEVGSCFCLRLPL 662
|
|
| HATPase_CpxA-like |
cd16949 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
272-378 |
5.18e-16 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.
Pssm-ID: 340425 [Multi-domain] Cd Length: 104 Bit Score: 73.13 E-value: 5.18e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447491076 272 LSQLFTNVVSNAIKHSadNTKILISAKSNHEKNILVcnVINFGTQIPEENRADIFRRFVKGNQGMGTESGGTGLGLSIAR 351
Cdd:cd16949 1 LARALENVLRNALRYS--PSKILLDISQDGDQWTIT--ITDDGPGVPEDQLEQIFLPFYRVDSARDRESGGTGLGLAIAE 76
|
90 100
....*....|....*....|....*...
gi 1447491076 352 WAALLHHGNIRVVDDKR-GVNFEITLPL 378
Cdd:cd16949 77 RAIEQHGGKIKASNRKPgGLRVRIWLPA 104
|
|
| HATPase_VanS-like |
cd16923 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
272-377 |
8.99e-16 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.
Pssm-ID: 340400 [Multi-domain] Cd Length: 102 Bit Score: 72.42 E-value: 8.99e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447491076 272 LSQLFTNVVSNAIKHSADNTKILISAKSNHEKNILvcNVINFGTQIPEENRADIFRRFVKGNQGMGTEsgGTGLGLSIAR 351
Cdd:cd16923 1 LQRVFSNLLSNAIKYSPENTRIYITSFLTDDVVNI--MFKNPSSHPLDFKLEKLFERFYRGDNSRNTE--GAGLGLSIAK 76
|
90 100
....*....|....*....|....*.
gi 1447491076 352 WAALLHHGNIRVVDDKRGVNFEITLP 377
Cdd:cd16923 77 AIIELHGGSASAEYDDNHDLFKVRLP 102
|
|
| HAMP |
cd06225 |
Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; ... |
107-152 |
3.90e-15 |
|
Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The structure of the Af1503 HAMP dimer from Archaeoglobus fulgidus has been solved using nuclear magnetic resonance, revealing a parallel four-helix bundle; this structure has been confirmed by cross-linking analysis of HAMP domains from the Escherichia coli aerotaxis receptor Aer. It has been suggested that the four-helix arrangement can rotate between the unusually packed conformation observed in the NMR structure and a canonical coiled-coil arrangement. Such rotation may coincide with signal transduction, but a common mechanism by which HAMP domains relay a variety of input signals has yet to be established.
Pssm-ID: 381743 [Multi-domain] Cd Length: 45 Bit Score: 68.63 E-value: 3.90e-15
10 20 30 40
....*....|....*....|....*....|....*....|....*.
gi 1447491076 107 TSPLRQMRDAAETMADGDYSVRVQIeSRKDEVGKLTLAFNEMAEEL 152
Cdd:cd06225 1 TRPLRRLTEAARRIAEGDLDVRVPV-RSKDEIGELARAFNQMAERL 45
|
|
| HATPase_BasS-like |
cd16940 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
259-376 |
1.15e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.
Pssm-ID: 340417 [Multi-domain] Cd Length: 113 Bit Score: 69.74 E-value: 1.15e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447491076 259 IENNIMLVGDKNRLSQLFTNVVSNAIKHSADNTKILISAKSNHEKNILVCNVinfGTQIPEENRADIFRRFVKGNqgmGT 338
Cdd:cd16940 1 SAADIQVQGDALLLFLLLRNLVDNAVRYSPQGSRVEIKLSADDGAVIRVEDN---GPGIDEEELEALFERFYRSD---GQ 74
|
90 100 110
....*....|....*....|....*....|....*...
gi 1447491076 339 ESGGTGLGLSIARWAALLHHGNIRvVDDKRGVNFEITL 376
Cdd:cd16940 75 NYGGSGLGLSIVKRIVELHGGQIF-LGNAQGGGLEAWV 111
|
|
| PRK11107 |
PRK11107 |
hybrid sensory histidine kinase BarA; Provisional |
164-349 |
2.24e-14 |
|
hybrid sensory histidine kinase BarA; Provisional
Pssm-ID: 236848 [Multi-domain] Cd Length: 919 Bit Score: 74.89 E-value: 2.24e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447491076 164 ANVSHELRTPVsalqamvenlaDGVV---------EPTPSNMEAIvnQT-----HKLADLITFLLDLSRVEAGAesLVIT 229
Cdd:PRK11107 298 ANMSHELRTPL-----------NGVIgftrqtlktPLTPTQRDYL--QTiersaNNLLAIINDILDFSKLEAGK--LVLE 362
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447491076 230 S--FDFKDFINnivETVK-IADAGH--NHSISLNIENNI--MLVGDKNRLSQLFTNVVSNAIKHSAD-NTKILISAKS-N 300
Cdd:PRK11107 363 NipFSLRETLD---EVVTlLAHSAHekGLELTLNIDPDVpdNVIGDPLRLQQIITNLVGNAIKFTESgNIDILVELRAlS 439
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 1447491076 301 HEKNILVCNVINFGTQIPEENRADIFRRFVKGNQGMGTESGGTGLGLSI 349
Cdd:PRK11107 440 NTKVQLEVQIRDTGIGISERQQSQLFQAFRQADASISRRHGGTGLGLVI 488
|
|
| PRK09303 |
PRK09303 |
histidine kinase; |
106-377 |
5.69e-14 |
|
histidine kinase;
Pssm-ID: 236462 [Multi-domain] Cd Length: 380 Bit Score: 72.68 E-value: 5.69e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447491076 106 LTSPLRQMRDAAETMadgdysvrvQIEsrkDEVGKLTLAFNEMAEELEHADNmrrdLIANVSHELRTPVSALQAMVENLA 185
Cdd:PRK09303 114 QPSEIDSGRYSQELL---------QLS---DELFVLRQENETLLEQLKFKDR----VLAMLAHDLRTPLTAASLALETLE 177
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447491076 186 ----DGVVEPTPSNME----AIVNQTHKLADLITFLLDLSRVEAGAESLVITSFDFKDFINNIVETVKIADAGHNHSISL 257
Cdd:PRK09303 178 lgqiDEDTELKPALIEqlqdQARRQLEEIERLITDLLEVGRTRWEALRFNPQKLDLGSLCQEVILELEKRWLAKSLEIQT 257
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447491076 258 NIENNIMLV-GDKNRLSQLFTNVVSNAIKHSADNTKILISA--KSNHEKNILVCNVinfGTQIPEENRADIFRRFVKGNQ 334
Cdd:PRK09303 258 DIPSDLPSVyADQERIRQVLLNLLDNAIKYTPEGGTITLSMlhRTTQKVQVSICDT---GPGIPEEEQERIFEDRVRLPR 334
|
250 260 270 280
....*....|....*....|....*....|....*....|....
gi 1447491076 335 GMGTEsgGTGLGLSIARWAALLHHGNIRVVDD-KRGVNFEITLP 377
Cdd:PRK09303 335 DEGTE--GYGIGLSVCRRIVRVHYGQIWVDSEpGQGSCFHFTLP 376
|
|
| HAMP |
smart00304 |
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; |
104-155 |
1.03e-12 |
|
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain;
Pssm-ID: 197640 [Multi-domain] Cd Length: 53 Bit Score: 62.27 E-value: 1.03e-12
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|..
gi 1447491076 104 RGLTSPLRQMRDAAETMADGDYSVRVQIESRkDEVGKLTLAFNEMAEELEHA 155
Cdd:smart00304 1 RRLLRPLRRLAEAAQRIADGDLTVRLPVDGR-DEIGELARAFNEMADRLEET 51
|
|
| NarQ |
COG3850 |
Signal transduction histidine kinase NarQ, nitrate/nitrite-specific [Signal transduction ... |
85-376 |
1.81e-12 |
|
Signal transduction histidine kinase NarQ, nitrate/nitrite-specific [Signal transduction mechanisms];
Pssm-ID: 443059 [Multi-domain] Cd Length: 448 Bit Score: 68.37 E-value: 1.81e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447491076 85 WIAMPLTLAVALGITYAFSRGLTSPLRQMRDAAETMADGDYSVRVQIESRkDEVGKLTLAFNEMAEEL--------EHAD 156
Cdd:COG3850 121 LLRLLLALLLALLLAYLLRRRIVRPLRRLTQAAERIARGDFDARVPVSGR-DELGTLARAFNRMADELqelyaeleEEEE 199
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447491076 157 NMRRDLIANVSHELRTPVSALQAMVENLADGVVEPTPSNMEAIVNQTHKLADLITFLLDLSRVEAGAESLVITSFDFKDF 236
Cdd:COG3850 200 LEAELELLALLDELLLLAALLLLLALLLALLLAALLAALLLLLLLQDALAESELLALNILAGLLELLLALLLLLLASALL 279
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447491076 237 INNIVETVKIADAGHNHSISLNIENNIMLVGDKNRLSQLFTNVVSNAIKHSADNTKILISAKSNHEKNILVCNVINFGTQ 316
Cdd:COG3850 280 LLELELLALLLELVELLALAAAEEALLLLVELAALLLLLLLQAIANASLLLIALASVVAALLELASILALQAALEAAAAG 359
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447491076 317 IPEENRADIFRRFVKGNQGMGTESGGTGLGLSIARWAALLHHGNIRVVDDKRGVNFEITL 376
Cdd:COG3850 360 AALAAAAAAAGLARALAQAGADAAEALGLLAEASEGAAGQGAGLVDVEGGVAGEGGLVVL 419
|
|
| PRK11360 |
PRK11360 |
two-component system sensor histidine kinase AtoS; |
162-378 |
2.60e-12 |
|
two-component system sensor histidine kinase AtoS;
Pssm-ID: 236901 [Multi-domain] Cd Length: 607 Bit Score: 68.07 E-value: 2.60e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447491076 162 LIANVSHELRTPVSALQAMVENLADGV-VEPTPSNMEAIVNQTHKLADLITFLLDLSRveaGAESlVITSFDFKDFINNI 240
Cdd:PRK11360 393 LVAGVAHEIRNPLTAIRGYVQIWRQQTsDPPSQEYLSVVLREVDRLNKVIDQLLEFSR---PRES-QWQPVSLNALVEEV 468
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447491076 241 VETVKIADAGHNHSISLNIENNIMLV-GDKNRLSQLFTNVVSNAIKHSADNTKILISAKSNHEKNILVcNVINFGTQIPE 319
Cdd:PRK11360 469 LQLFQTAGVQARVDFETELDNELPPIwADPELLKQVLLNILINAVQAISARGKIRIRTWQYSDGQVAV-SIEDNGCGIDP 547
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447491076 320 ENRADIFRRFvkgnqgMGTESGGTGLGLSIARWAALLHHGNIRVVDD-KRGVNFEITLPL 378
Cdd:PRK11360 548 ELLKKIFDPF------FTTKAKGTGLGLALSQRIINAHGGDIEVESEpGVGTTFTLYLPI 601
|
|
| HATPase_TutC-TodS-like |
cd16925 |
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ... |
268-377 |
3.94e-12 |
|
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.
Pssm-ID: 340402 [Multi-domain] Cd Length: 110 Bit Score: 62.51 E-value: 3.94e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447491076 268 DKNRLSQLFTNVVSNAIKHSADNTKILISAKSNHEKNILVcNVINFGTQIPEENRADIFRRFVKGNQGMGTESGGTGLGL 347
Cdd:cd16925 1 DAEKYERVVLNLLSNAFKFTPDGGRIRCILEKFRLNRFLL-TVSDSGPGIPPNLREEIFERFRQGDGSSTRAHGGTGLGL 79
|
90 100 110
....*....|....*....|....*....|.
gi 1447491076 348 SIARWAALLHHGNIRVVD-DKRGVNFEITLP 377
Cdd:cd16925 80 SIVKEFVELHGGTVTVSDaPGGGALFQVELP 110
|
|
| HATPase_EvgS-ArcB-TorS-like |
cd16922 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ... |
272-378 |
4.48e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340399 [Multi-domain] Cd Length: 110 Bit Score: 62.13 E-value: 4.48e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447491076 272 LSQLFTNVVSNAIKHSADNTkILISAK---SNHEKNILVCNVINFGTQIPEENRADIFRRFVKGNQGMGTESGGTGLGLS 348
Cdd:cd16922 1 LRQILLNLLGNAIKFTEEGE-VTLRVSleeEEEDGVQLRFSVEDTGIGIPEEQQARLFEPFSQADSSTTRKYGGTGLGLA 79
|
90 100 110
....*....|....*....|....*....|.
gi 1447491076 349 IARWAALLHHGNIRVV-DDKRGVNFEITLPL 378
Cdd:cd16922 80 ISKKLVELMGGDISVEsEPGQGSTFTFTLPL 110
|
|
| HisKA |
pfam00512 |
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ... |
158-222 |
4.81e-12 |
|
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.
Pssm-ID: 459839 [Multi-domain] Cd Length: 66 Bit Score: 60.69 E-value: 4.81e-12
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1447491076 158 MRRDLIANVSHELRTPVSALQAMVENLADGVVEPTPSNM-EAIVNQTHKLADLITFLLDLSRVEAG 222
Cdd:pfam00512 1 AKSEFLANLSHELRTPLTAIRGYLELLRDEKLDEEQREYlETILRSAERLLRLINDLLDLSRIEAG 66
|
|
| Tar |
COG0840 |
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms]; |
92-190 |
5.98e-12 |
|
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];
Pssm-ID: 440602 [Multi-domain] Cd Length: 533 Bit Score: 66.97 E-value: 5.98e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447491076 92 LAVALGITYAFSRGLTSPLRQMRDAAETMADGDYSVRVQIESRkDEVGKLTLAFNEMAEELehadnmrRDLIANV---SH 168
Cdd:COG0840 192 VALAIILALLLSRSITRPLRELLEVLERIAEGDLTVRIDVDSK-DEIGQLADAFNRMIENL-------RELVGQVresAE 263
|
90 100
....*....|....*....|..
gi 1447491076 169 ELRTPVSALQAMVENLADGVVE 190
Cdd:COG0840 264 QVASASEELAASAEELAAGAEE 285
|
|
| HAMP |
COG2770 |
HAMP domain [Signal transduction mechanisms]; |
48-363 |
6.74e-12 |
|
HAMP domain [Signal transduction mechanisms];
Pssm-ID: 442051 [Multi-domain] Cd Length: 631 Bit Score: 67.06 E-value: 6.74e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447491076 48 AIGFFTSLKGELSAIIVFATAIAFVMAWFLLKVGLsgwiampLTLAVALGITYAFSRGLTSPLRQMRDAAETMADGDYSV 127
Cdd:COG2770 185 ALLAALLLLLLGGLLLVVLLEAALAALLLLLLLAL-------LALLLALLLALLLARRITRPLRRLAEAARRIAAGDLDV 257
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447491076 128 RVQIEsRKDEVGKLTLAFNEMAEELEHADNMRRDLIANVSHELRTPVSALQAMVENLADGVVEPTPSNMEAIVNQTHKLA 207
Cdd:COG2770 258 RIPVS-RKDEIGELARAFNRMADSLRESIEEAEEEEELAEAELARLLEALLELLLALLLLLLALLLLAAAALLLELLLLL 336
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447491076 208 DLITFLLDLSRVEAGAESLVITSFDFKDFINNIVETVKIADAGHNHSISLNIENNIMLVGDKNRLSQLFTNVVSNAIKHS 287
Cdd:COG2770 337 LLALLLLLLLAADLLLALALAALLLLLALELLLEAELLVLLALEALALEAELAAVLALLAALAAALLLLELALEELVLAL 416
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1447491076 288 ADNTKILISAKSNHEKNILVCNVINFGTQIPEENRADIFRRFVKGNQGMGTESGGTGLGLSIARWAALLHHGNIRV 363
Cdd:COG2770 417 LALALLALAAAAAAAEAAAAALELAAAAIAAAAAAEAEGGLAELEAEELVAAAEALLLLAALLLLAALGALELLLL 492
|
|
| CitA |
COG3290 |
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ... |
146-378 |
7.11e-12 |
|
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];
Pssm-ID: 442519 [Multi-domain] Cd Length: 389 Bit Score: 66.41 E-value: 7.11e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447491076 146 NEMAEELEHADNMRRDLIANvSHELRTPVSALQAMVENladgvveptpsnmeaivNQTHKLADLITFLLDLSRVEAGAES 225
Cdd:COG3290 177 ERLEEELEGVKELAEALRAQ-RHDFRNHLHTISGLLQL-----------------GEYDEALEYIDEISEELQELIDSLL 238
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447491076 226 LVITSFDFKDFINNivetvKIADAgHNHSISLNIENNIMLVGDK---NRLSQLFTNVVSNAIKHSADNTKI--LISAKSN 300
Cdd:COG3290 239 SRIGNPVLAALLLG-----KAARA-RERGIDLTIDIDSDLPDLPlsdTDLVTILGNLLDNAIEAVEKLPEEerRVELSIR 312
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447491076 301 HEKNILVCNVINFGTQIPEENRADIFRRfvkgnqGMGT-ESGGTGLGLSIARWAALLHHGNIRV-VDDKRGVNFEITLPL 378
Cdd:COG3290 313 DDGDELVIEVEDSGPGIPEELLEKIFER------GFSTkLGEGRGLGLALVKQIVEKYGGTIEVeSEEGEGTVFTVRLPK 386
|
|
| HAMP |
pfam00672 |
HAMP domain; |
102-154 |
1.22e-11 |
|
HAMP domain;
Pssm-ID: 459898 [Multi-domain] Cd Length: 53 Bit Score: 59.18 E-value: 1.22e-11
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 1447491076 102 FSRGLTSPLRQMRDAAETMADGDYSVRVQIeSRKDEVGKLTLAFNEMAEELEH 154
Cdd:pfam00672 2 LARRILRPLRRLAEAARRIASGDLDVRLPV-SGRDEIGELARAFNQMAERLRE 53
|
|
| HisKA |
smart00388 |
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ... |
158-222 |
1.55e-11 |
|
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.
Pssm-ID: 214644 [Multi-domain] Cd Length: 66 Bit Score: 59.12 E-value: 1.55e-11
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1447491076 158 MRRDLIANVSHELRTPVSALQAMVENLADGVVEPTPSNM-EAIVNQTHKLADLITFLLDLSRVEAG 222
Cdd:smart00388 1 AKREFLANLSHELRTPLTAIRGYLELLLDTELSEEQREYlETILREAERLLRLINDLLDLSRIEAG 66
|
|
| PRK09959 |
PRK09959 |
acid-sensing system histidine kinase EvgS; |
159-378 |
3.54e-11 |
|
acid-sensing system histidine kinase EvgS;
Pssm-ID: 182169 [Multi-domain] Cd Length: 1197 Bit Score: 65.14 E-value: 3.54e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447491076 159 RRDLIANVSHELRTPVSALQAMVEnLADGVVEPTPSNMEAI---VNQTHKLADLITFLLDLSRVEAGAESLVITSFDFKD 235
Cdd:PRK09959 712 KSQFLATMSHEIRTPISSIMGFLE-LLSGSGLSKEQRVEAIslaYATGQSLLGLIGEILDVDKIESGNYQLQPQWVDIPT 790
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447491076 236 FINNIVETVKIADAGHNHSISLN--IENNIMLVGDKNRLSQLFTNVVSNAIKHSADN----TKILISAKSNHEknILVCN 309
Cdd:PRK09959 791 LVQNTCHSFGAIAASKSIALSCSstFPDHYLVKIDPQAFKQVLSNLLSNALKFTTEGavkiTTSLGHIDDNHA--VIKMT 868
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447491076 310 VINFGTQIPEENRADIFRRFVKGNQgmGTESGGTGLGLSIARWAALLHHGNIRVVDDKR-GVNFEITLPL 378
Cdd:PRK09959 869 IMDSGSGLSQEEQQQLFKRYSQTSA--GRQQTGSGLGLMICKELIKNMQGDLSLESHPGiGTTFTITIPV 936
|
|
| HATPase_BaeS-like |
cd16946 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
268-361 |
3.68e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.
Pssm-ID: 340422 [Multi-domain] Cd Length: 109 Bit Score: 59.78 E-value: 3.68e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447491076 268 DKNRLSQLFTNVVSNAIKHSADNTKILISAKSnhEKNILVCNVINFGTQIPEENRADIFRRFVKGNQGMGTESGGTGLGL 347
Cdd:cd16946 1 DRDRLQQLFVNLLENSLRYTDTGGKLRIRAAQ--TPQEVRLDVEDSAPGVSDDQLARLFERFYRVESSRNRASGGSGLGL 78
|
90
....*....|....
gi 1447491076 348 SIARWAALLHHGNI 361
Cdd:cd16946 79 AICHNIALAHGGTI 92
|
|
| COG4192 |
COG4192 |
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ... |
86-363 |
6.24e-11 |
|
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];
Pssm-ID: 443346 [Multi-domain] Cd Length: 640 Bit Score: 63.94 E-value: 6.24e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447491076 86 IAMPLTLAVALGITYAF-SRGLTSPLRQMRDAAETMADGDYSVRVQIEsRKDEVG---KLTLAF----NEMAEELE---- 153
Cdd:COG4192 330 AIALLSLLLAVLINYFYvRRRLVKRLNALSDAMAAIAAGDLDVPIPVD-GNDEIGriaRLLRVFrdqaIEKTQELEteie 408
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447491076 154 -------HADNMRRDLI------------ANVSHELRTPVSALQAMVEN----LADGVVEPTPSNMEAIVNQTHKLADLI 210
Cdd:COG4192 409 erkriekNLRQTQDELIqaakmavvgqtmTSLAHELNQPLNAMSMYLFSakkaLEQENYAQLPTSLDKIEGLIERMDKII 488
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447491076 211 TFLLDLSRveAGAESLviTSFDFKDFINNIVETVkiADAGHNHSISLNIENNIMLVGDKNRLSQLFTNVVSNAIKHSADN 290
Cdd:COG4192 489 KSLRQFSR--KSDTPL--QPVDLRQVIEQAWELV--ESRAKPQQITLHIPDDLMVQGDQVLLEQVLVNLLVNALDAVATQ 562
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1447491076 291 TKILISAKSNHEKniLVCNVINFGTQIPEENRadIFRRFVKgnqgmgTESGGTGLGLSIARWAALLHHGNIRV 363
Cdd:COG4192 563 PQISVDLLSNAEN--LRVAISDNGNGWPLVDK--LFTPFTT------TKEVGLGLGLSICRSIMQQFGGDLYL 625
|
|
| PRK10337 |
PRK10337 |
sensor protein QseC; Provisional |
73-376 |
6.72e-11 |
|
sensor protein QseC; Provisional
Pssm-ID: 182388 [Multi-domain] Cd Length: 449 Bit Score: 63.51 E-value: 6.72e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447491076 73 MAWFLLKVGLSGW-IAMPLTLAValgITYAFSRGLtSPLRQMRdAAETMADGDYSVRVQIESRKDEVGKLTLAFNEMAEE 151
Cdd:PRK10337 155 MALAIVAGQLIPWlVALPIMLII---LMVLLGREL-APLKKLA-LALRMRDPDSETPLNATGVPSEVRPLVEALNQLFAR 229
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447491076 152 LeHADNMR-RDLIANVSHELRTPVSAL--QAMVENLADGvvepTPSNMEAIVNQTHKLAD----LITFLLDLSRVEAGAE 224
Cdd:PRK10337 230 T-HAMMVReRRFTSDAAHELRSPLAALkvQTEVAQLSDD----DPQARKKALLQLHAGIDratrLVDQLLTLSRLDSLDN 304
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447491076 225 SLVITSFDFKDFINNIVetVKIADAGHNHSISLNIENNIMLV---GDKNRLSQLFTNVVSNAIKHSADNTKILISAKSNH 301
Cdd:PRK10337 305 LQDVAEIPLEDLLQSAV--MDIYHTAQQAGIDVRLTLNAHPVirtGQPLLLSLLVRNLLDNAIRYSPQGSVVDVTLNARN 382
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1447491076 302 EKnilvcnVINFGTQIPEENRADIFRRFVKGNqgmGTESGGTGLGLSIARWAALLHHGNIRvVDDKRGVNFEITL 376
Cdd:PRK10337 383 FT------VRDNGPGVTPEALARIGERFYRPP---GQEATGSGLGLSIVRRIAKLHGMNVS-FGNAPEGGFEAKV 447
|
|
| KinA |
COG5805 |
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ... |
148-379 |
7.06e-11 |
|
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444507 [Multi-domain] Cd Length: 496 Bit Score: 63.60 E-value: 7.06e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447491076 148 MAEELehadnMRR--------DLIANVSHELRTPVSALQamvenladGVVEPTPSNMEaivnQTHKLADLItfLLDLSRV 219
Cdd:COG5805 273 EAEEL-----MARseklsiagQLAAGIAHEIRNPLTSIK--------GFLQLLQPGIE----DKEEYFDIM--LSELDRI 333
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447491076 220 E---------AGAESLVITSFDFKDFINNIVeTVKIADAG-HNHSISLN-IENNIMLVGDKNRLSQLFTNVVSNAIKHSA 288
Cdd:COG5805 334 EsiiseflalAKPQAVNKEKENINELIQDVV-TLLETEAIlHNIQIRLElLDEDPFIYCDENQIKQVFINLIKNAIEAMP 412
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447491076 289 DNTKILISAKSNHEKnILVCnVINFGTQIPEENRADIFRRFvkgnqgMGTESGGTGLGLSIARWAALLHHGNIRVVDDK- 367
Cdd:COG5805 413 NGGTITIHTEEEDNS-VIIR-VIDEGIGIPEERLKKLGEPF------FTTKEKGTGLGLMVSYKIIENHNGTIDIDSKVg 484
|
250
....*....|..
gi 1447491076 368 RGVNFEITLPLT 379
Cdd:COG5805 485 KGTTFTITLPLS 496
|
|
| glnL |
PRK11073 |
nitrogen regulation protein NR(II); |
150-378 |
8.53e-11 |
|
nitrogen regulation protein NR(II);
Pssm-ID: 182947 [Multi-domain] Cd Length: 348 Bit Score: 62.79 E-value: 8.53e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447491076 150 EELEHADNMR-RDLIANVSHELRTPVSALQAMVENLADGVvePTPSNME---AIVNQTHKLADLITFLLDLSRveAGAES 225
Cdd:PRK11073 120 EQLQHAQQVAaRDLVRGLAHEIKNPLGGLRGAAQLLSKAL--PDPALTEytkVIIEQADRLRNLVDRLLGPQR--PGTHV 195
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447491076 226 lvitsfdfKDFINNIVETVKiadaghnHSISLNIENNIMLVGD-----------KNRLSQLFTNVVSNAIKH-SADNTKI 293
Cdd:PRK11073 196 --------TESIHKVAERVV-------QLVSLELPDNVRLIRDydpslpelahdPDQIEQVLLNIVRNALQAlGPEGGTI 260
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447491076 294 LISAKSNHEKNI------LVC--NVINFGTQIPEENRADIFRRFVKGNQGmgtesgGTGLGLSIARWAALLHHGNIRVVD 365
Cdd:PRK11073 261 TLRTRTAFQLTLhgeryrLAAriDIEDNGPGIPPHLQDTLFYPMVSGREG------GTGLGLSIARNLIDQHSGKIEFTS 334
|
250
....*....|...
gi 1447491076 366 DKRGVNFEITLPL 378
Cdd:PRK11073 335 WPGHTEFSVYLPI 347
|
|
| HATPase_RstB-like |
cd16939 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
272-378 |
1.27e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.
Pssm-ID: 340416 [Multi-domain] Cd Length: 104 Bit Score: 57.83 E-value: 1.27e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447491076 272 LSQLFTNVVSNAIKHSAdnTKILISAKSNHEKniLVCNVINFGTQIPEENRADIFRRFVKGNQGMGTESGGTGLGLSIAR 351
Cdd:cd16939 1 MARALDNLLRNALRYAH--RTVRIALLVSGGR--LTLIVEDDGPGIPAAARERVFEPFVRLDPSRDRATGGFGLGLAIVH 76
|
90 100
....*....|....*....|....*...
gi 1447491076 352 WAALLHHGNIRVVDDKR-GVNFEITLPL 378
Cdd:cd16939 77 RVALWHGGHVECDDSELgGACFRLTWPR 104
|
|
| PRK10841 |
PRK10841 |
two-component system sensor histidine kinase RcsC; |
124-378 |
2.85e-10 |
|
two-component system sensor histidine kinase RcsC;
Pssm-ID: 182772 [Multi-domain] Cd Length: 924 Bit Score: 61.91 E-value: 2.85e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447491076 124 DYSVRVQIESrkdevgkltlAFNEMAEELEHADNMRRDLIANVSHELRTPvsaLQAMVENLADGVVEPTPSNMEAIV--- 200
Cdd:PRK10841 422 DVSARVKMEE----------SLQEMAQAAEQASQSKSMFLATVSHELRTP---LYGIIGNLDLLQTKELPKGVDRLVtam 488
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447491076 201 -NQTHKLADLITFLLDLSRVEAgaESLVITSFDF--KDFINNIVET-----VKiadaghnHSISLN--IENNI--MLVGD 268
Cdd:PRK10841 489 nNSSSLLLKIISDILDFSKIES--EQLKIEPREFspREVINHITANylplvVK-------KRLGLYcfIEPDVpvALNGD 559
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447491076 269 KNRLSQLFTNVVSNAIKHSaDNTKILISAKSNHekNILVCNVINFGTQIPEENRADIFRRFVKGNQGMGTESGGTGLGLS 348
Cdd:PRK10841 560 PMRLQQVISNLLSNAIKFT-DTGCIVLHVRVDG--DYLSFRVRDTGVGIPAKEVVRLFDPFFQVGTGVQRNFQGTGLGLA 636
|
250 260 270
....*....|....*....|....*....|.
gi 1447491076 349 IARWAALLHHGNIRVVDDKR-GVNFEITLPL 378
Cdd:PRK10841 637 ICEKLINMMDGDISVDSEPGmGSQFTIRIPL 667
|
|
| HisKA |
cd00082 |
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ... |
156-218 |
2.86e-10 |
|
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.
Pssm-ID: 119399 [Multi-domain] Cd Length: 65 Bit Score: 55.68 E-value: 2.86e-10
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1447491076 156 DNMRRDLIANVSHELRTPVSALQAMVENLADGVVEPTPS--NMEAIVNQTHKLADLITFLLDLSR 218
Cdd:cd00082 1 LQAKGEFLANVSHELRTPLTAIRGALELLEEELLDDEEQreYLERIREEAERLLRLINDLLDLSR 65
|
|
| PRK13837 |
PRK13837 |
two-component system VirA-like sensor kinase; |
101-379 |
3.65e-10 |
|
two-component system VirA-like sensor kinase;
Pssm-ID: 237526 [Multi-domain] Cd Length: 828 Bit Score: 61.62 E-value: 3.65e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447491076 101 AFSRGLTSP---LRQMRDAAETMADgdYSVRVQIESRKDEVGKltlafnemaeELEHADNMRR--DLIANVSHELRTPVS 175
Cdd:PRK13837 399 RQRYGLRPPageLQLLELALDCLAH--AIERRRLETERDALER----------RLEHARRLEAvgTLASGIAHNFNNILG 466
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447491076 176 ALQAMVEnLADGVVEPTPS---NMEAIVNQTHKLADLITFLLDLSRVEAGaeslVITSFDFKDFINNIVETVKIADAGHN 252
Cdd:PRK13837 467 AILGYAE-MALNKLARHSRaarYIDEIISAGARARLIIDQILAFGRKGER----NTKPFDLSELVTEIAPLLRVSLPPGV 541
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447491076 253 hSISLNIENNIMLV-GDKNRLSQLFTNVVSNAIKHSADNTKILISAK----------SNHE---KNILVCNVINFGTQIP 318
Cdd:PRK13837 542 -ELDFDQDQEPAVVeGNPAELQQVLMNLCSNAAQAMDGAGRVDISLSraklrapkvlSHGVlppGRYVLLRVSDTGAGID 620
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1447491076 319 EENRADIFRRFVKgnqgmgTESGGTGLGLSIARWAALLHHGNIRVVDD-KRGVNFEITLPLT 379
Cdd:PRK13837 621 EAVLPHIFEPFFT------TRAGGTGLGLATVHGIVSAHAGYIDVQSTvGRGTRFDVYLPPS 676
|
|
| YesM |
COG2972 |
Sensor histidine kinase YesM [Signal transduction mechanisms]; |
85-348 |
3.17e-09 |
|
Sensor histidine kinase YesM [Signal transduction mechanisms];
Pssm-ID: 442211 [Multi-domain] Cd Length: 445 Bit Score: 58.11 E-value: 3.17e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447491076 85 WIAMPLTLAVALGITYAFSRGLTSPLRQMRDAAETMADGDYsVRVQIEsRKDEVGKLTLAFNEMAEEL-EHADNMRRDLI 163
Cdd:COG2972 160 LLIILLLLLLALLLSYLLSRSITRPIKRLKKAMKKVEKGDL-VRLEVS-GNDEIGILARSFNEMVERIkELIEEVYELEL 237
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447491076 164 ANVSHELRtpvsALQAMVE-----NLADGVveptpsNMEAIVNQTHKLADLITFLLDLSRVEAGAESLVITSFDFKDFIN 238
Cdd:COG2972 238 EKKEAELK----ALQAQINphflfNTLNSI------RWLAELEDPEEAEEMLEALSKLLRYSLSKGDELVTLEEELELIK 307
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447491076 239 NIVEtVKIADAGHNHSISLNIENNIMLVGDKNRLSQLFtnvVSNAIKH----SADNTKILISAKsnHEKNILVCNVINFG 314
Cdd:COG2972 308 SYLE-IQKLRFGDRLEVEIEIDEELLDLLIPKLILQPL---VENAIEHgiepKEGGGTIRISIR--KEGDRLVITVEDNG 381
|
250 260 270
....*....|....*....|....*....|....
gi 1447491076 315 TQIPEENRADIFRRFvkgnqgmGTESGGTGLGLS 348
Cdd:COG2972 382 VGMPEEKLEKLLEEL-------SSKGEGRGIGLR 408
|
|
| HATPase_EnvZ-like |
cd16950 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
272-369 |
8.69e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.
Pssm-ID: 340426 [Multi-domain] Cd Length: 101 Bit Score: 52.45 E-value: 8.69e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447491076 272 LSQLFTNVVSNAIKHSadntKILISAKSNHEKNILVCNVINFGTQIPEENRADIFRRFVKGNQGMGTesGGTGLGLSIAR 351
Cdd:cd16950 1 LKRVLSNLVDNALRYG----GGWVEVSSDGEGNRTRIQVLDNGPGIAPEEVDELFQPFYRGDNARGT--SGTGLGLAIVQ 74
|
90
....*....|....*...
gi 1447491076 352 WAALLHHGNIRVVDDKRG 369
Cdd:cd16950 75 RISDAHGGSLTLANRAGG 92
|
|
| PRK11091 |
PRK11091 |
aerobic respiration control sensor protein ArcB; Provisional |
149-378 |
2.27e-08 |
|
aerobic respiration control sensor protein ArcB; Provisional
Pssm-ID: 236842 [Multi-domain] Cd Length: 779 Bit Score: 56.10 E-value: 2.27e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447491076 149 AEELEHADNMRRDLIANVSHELRTPVSALQAMVENLADgvvepTPSNME--AIVNQTHKLAdlITF------LLDLSRVE 220
Cdd:PRK11091 273 QDALEKASRDKTTFISTISHELRTPLNGIVGLSRILLD-----TELTAEqrKYLKTIHVSA--ITLgnifndIIDMDKME 345
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447491076 221 AGAESLVITSFDFKDFINNIVETVKI--ADAGhnhsISLNIENNIML----VGDKNRLSQLFTNVVSNAIKHSADNtKIL 294
Cdd:PRK11091 346 RRKLQLDNQPIDFTDFLADLENLSGLqaEQKG----LRFDLEPLLPLphkvITDGTRLRQILWNLISNAVKFTQQG-GVT 420
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447491076 295 ISAkSNHEKNILVCNVINFGTQIPEENRADIFRRF--VKGNQGmGTESGGTGLGLSIARWAALLHHGNIRVVDDK-RGVN 371
Cdd:PRK11091 421 VRV-RYEEGDMLTFEVEDSGIGIPEDELDKIFAMYyqVKDSHG-GKPATGTGIGLAVSKRLAQAMGGDITVTSEEgKGSC 498
|
....*..
gi 1447491076 372 FEITLPL 378
Cdd:PRK11091 499 FTLTIHA 505
|
|
| HATPase_BvrS-ChvG-like |
cd16953 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
272-377 |
2.48e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.
Pssm-ID: 340429 [Multi-domain] Cd Length: 110 Bit Score: 51.42 E-value: 2.48e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447491076 272 LSQLFTNVVSNAIKHSADNTkILISAKSNHEKNILVCNVINFGTQIPEENRADIFRRFVK---GNQGMGTESggtGLGLS 348
Cdd:cd16953 1 LGQVLRNLIGNAISFSPPDT-GRITVSAMPTGKMVTISVEDEGPGIPQEKLESIFDRFYTerpANEAFGQHS---GLGLS 76
|
90 100 110
....*....|....*....|....*....|....
gi 1447491076 349 IARWAALLHHG-----NIRVVDDKRGVNFEITLP 377
Cdd:cd16953 77 ISRQIIEAHGGisvaeNHNQPGQVIGARFTVQLP 110
|
|
| HATPase_Glnl-NtrB-like |
cd16918 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
272-377 |
3.07e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).
Pssm-ID: 340395 [Multi-domain] Cd Length: 109 Bit Score: 51.25 E-value: 3.07e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447491076 272 LSQLFTNVVSNAIKHSADNT-KILISAKSNHEKNI------LVC--NVINFGTQIPEENRADIFRRFVKGNQGmgtesgG 342
Cdd:cd16918 1 LIQVFLNLVRNAAQALAGSGgEIILRTRTQRQVTLghprhrLALrvSVIDNGPGIPPDLQDTIFYPMVSGREN------G 74
|
90 100 110
....*....|....*....|....*....|....*
gi 1447491076 343 TGLGLSIARWAALLHHGNIRVVDDKRGVNFEITLP 377
Cdd:cd16918 75 TGLGLAIAQNIVSQHGGVIECDSQPGHTVFSVSLP 109
|
|
| HATPase_FilI-like |
cd16921 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
272-377 |
8.44e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340398 [Multi-domain] Cd Length: 105 Bit Score: 50.02 E-value: 8.44e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447491076 272 LSQLFTNVVSNAIK--HSADNTKILISAKSNHEKNILvcNVINFGTQIPEENRADIFRRFvkgnQGMGT--ESGGTGLGL 347
Cdd:cd16921 1 LGQVLTNLLGNAIKfrRPRRPPRIEVGAEDVGEEWTF--YVRDNGIGIDPEYAEKVFGIF----QRLHSreEYEGTGVGL 74
|
90 100 110
....*....|....*....|....*....|.
gi 1447491076 348 SIARWAALLHHGNIRVVDDK-RGVNFEITLP 377
Cdd:cd16921 75 AIVRKIIERHGGRIWLESEPgEGTTFYFTLP 105
|
|
| HATPase_AtoS-like |
cd16943 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
272-378 |
1.32e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.
Pssm-ID: 340419 [Multi-domain] Cd Length: 105 Bit Score: 49.34 E-value: 1.32e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447491076 272 LSQLFTNVVSNAIKHSADNTKILISAKSNHEKNILVcnVINFGTQIPEENRADIFRRFVKgNQGMGTesgGTGLGLSIAR 351
Cdd:cd16943 4 LNQVLLNLLVNAAQAMEGRGRITIRTWAHVDQVLIE--VEDTGSGIDPEILGRIFDPFFT-TKPVGE---GTGLGLSLSY 77
|
90 100
....*....|....*....|....*...
gi 1447491076 352 WAALLHHGNIRVVDDK-RGVNFEITLPL 378
Cdd:cd16943 78 RIIQKHGGTIRVASVPgGGTRFTIILPI 105
|
|
| HATPase_TmoS-FixL-DctS-like |
cd16920 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
272-377 |
2.10e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340397 [Multi-domain] Cd Length: 104 Bit Score: 48.93 E-value: 2.10e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447491076 272 LSQLFTNVVSNAIK---HSADNTKILISAKSNHEKNILVCNVINFGTQIPEENRADIFRRFVKgnqgmgTESGGTGLGLS 348
Cdd:cd16920 1 IQQVLINLVRNGIEamsEGGCERRELTIRTSPADDRAVTISVKDTGPGIAEEVAGQLFDPFYT------TKSEGLGMGLS 74
|
90 100 110
....*....|....*....|....*....|
gi 1447491076 349 IARWAALLHHGNIRVV-DDKRGVNFEITLP 377
Cdd:cd16920 75 ICRSIIEAHGGRLSVEsPAGGGATFQFTLP 104
|
|
| HATPase_PhoQ-like |
cd16954 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
254-376 |
2.52e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.
Pssm-ID: 340430 [Multi-domain] Cd Length: 135 Bit Score: 49.17 E-value: 2.52e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447491076 254 SISLNIENNIMLVGDKNRLSQLFTNVVSNAIKHSadNTKILISAKSNHEKNILVcnVINFGTQIPEENRADIFRRFVKGN 333
Cdd:cd16954 20 SISLDISPELRFPGERNDLMELLGNLLDNACKWC--LEFVEVTARQTDGGLHLI--VDDDGPGVPESQRSKIFQRGQRLD 95
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 1447491076 334 qgmgTESGGTGLGLSIARWAALLHHGNIRVVDDKRG-VNFEITL 376
Cdd:cd16954 96 ----EQRPGQGLGLAIAKEIVEQYGGELSLSDSPLGgARFEVVF 135
|
|
| PRK10364 |
PRK10364 |
two-component system sensor histidine kinase ZraS; |
156-378 |
3.10e-07 |
|
two-component system sensor histidine kinase ZraS;
Pssm-ID: 236674 [Multi-domain] Cd Length: 457 Bit Score: 52.10 E-value: 3.10e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447491076 156 DNMRR--------DLIANVSHELRTPVSALQAmvenLADGVVEPTPSNMEA------IVNQTHKLADLITFLLDLSRvea 221
Cdd:PRK10364 226 DEMKRkeklvalgHLAAGVAHEIRNPLSSIKG----LAKYFAERAPAGGEAhqlaqvMAKEADRLNRVVSELLELVK--- 298
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447491076 222 gAESLVITSFDFKDFINNIVETVKiADAgHNHSISLNIENN-----IMLvgDKNRLSQLFTNVVSNAIKHSADNTKILIS 296
Cdd:PRK10364 299 -PTHLALQAVDLNDLINHSLQLVS-QDA-NSREIQLRFTANdtlpeIQA--DPDRLTQVLLNLYLNAIQAIGQHGVISVT 373
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447491076 297 AKSNHEKNILVcnVINFGTQIPEENRADIFRRFVKgnqgmgTESGGTGLGLSIARWAALLHHGNIRVVDDK-RGVNFEIT 375
Cdd:PRK10364 374 ASESGAGVKIS--VTDSGKGIAADQLEAIFTPYFT------TKAEGTGLGLAVVHNIVEQHGGTIQVASQEgKGATFTLW 445
|
...
gi 1447491076 376 LPL 378
Cdd:PRK10364 446 LPV 448
|
|
| PRK10815 |
PRK10815 |
two-component system sensor histidine kinase PhoQ; |
254-369 |
6.35e-07 |
|
two-component system sensor histidine kinase PhoQ;
Pssm-ID: 182754 [Multi-domain] Cd Length: 485 Bit Score: 51.17 E-value: 6.35e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447491076 254 SISLNIENNIMLVGDKNRLSQLFTNVVSNAIKHSADNTKilISAKSNHEKNILVcnVINFGTQIPEENRADIFRRfvkgN 333
Cdd:PRK10815 361 NITLDISPEITFVGEKNDFMEVMGNVLDNACKYCLEFVE--ISARQTDEHLHIV--VEDDGPGIPESKRELIFDR----G 432
|
90 100 110
....*....|....*....|....*....|....*.
gi 1447491076 334 QGMGTESGGTGLGLSIARWAALLHHGNIRVVDDKRG 369
Cdd:PRK10815 433 QRADTLRPGQGLGLSVAREITEQYEGKISAGDSPLG 468
|
|
| HATPase_BceS-YxdK-YvcQ-like |
cd16948 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
268-377 |
9.16e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.
Pssm-ID: 340424 [Multi-domain] Cd Length: 109 Bit Score: 46.90 E-value: 9.16e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447491076 268 DKNRLSQLFTNVVSNAIKHSADNTKILISAKSNHEKNILVcnVINFGTQIPEENRADIFRRFVKGNQGMgTESGGTGLGL 347
Cdd:cd16948 2 DAKWLSFIIGQIVSNALKYSKQGGKIEIYSETNEQGVVLS--IKDFGIGIPEEDLPRVFDKGFTGENGR-NFQESTGMGL 78
|
90 100 110
....*....|....*....|....*....|..
gi 1447491076 348 SIAR-WAALLHHgNIRV-VDDKRGVNFEITLP 377
Cdd:cd16948 79 YLVKkLCDKLGH-KIDVeSEVGEGTTFTITFP 109
|
|
| HATPase_YcbM-like |
cd16947 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
255-363 |
1.90e-06 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).
Pssm-ID: 340423 [Multi-domain] Cd Length: 125 Bit Score: 46.74 E-value: 1.90e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447491076 255 ISLNIEN-NIMLVGDKNRLSQLFTNVVSNAIKHSADNtKILISAKSNHEKNILVcNVINFGTQIPEENRADIFRRFVKGN 333
Cdd:cd16947 3 VEINIPDrPIYANANTEALQRILKNLISNAIKYGSDG-KFLGMTLREDEKHVYI-DIWDKGKGISETEKDHVFERLYTLE 80
|
90 100 110
....*....|....*....|....*....|
gi 1447491076 334 QGMGTESGGTGLGLSIARWAALLHHGNIRV 363
Cdd:cd16947 81 DSRNSAKQGNGLGLTITKRLAESMGGSIYV 110
|
|
| HATPase_SpaK_NisK-like |
cd16975 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
268-374 |
6.16e-06 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.
Pssm-ID: 340434 [Multi-domain] Cd Length: 107 Bit Score: 44.76 E-value: 6.16e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447491076 268 DKNRLSQLFTNVVSNAIKHSADNTKILISAKSnhEKNILVCNVINFGTQIPEENRADIFRRFVKGNQGMgTESGGTGLGL 347
Cdd:cd16975 1 DTLLLSRALINIISNACQYAPEGGTVSISIYD--EEEYLYFEIWDNGHGFSEQDLKKALELFYRDDTSR-RSGGHYGMGL 77
|
90 100 110
....*....|....*....|....*....|
gi 1447491076 348 SIARWAALLHHGNIRVVDDKRG---VNFEI 374
Cdd:cd16975 78 YIAKNLVEKHGGSLIIENSQKGgaeVTVKI 107
|
|
| HATPase_EcPhoR-like |
cd16952 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
272-358 |
6.42e-06 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.
Pssm-ID: 340428 [Multi-domain] Cd Length: 108 Bit Score: 44.50 E-value: 6.42e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447491076 272 LSQLFTNVVSNAIKHSADNTKILISAKSNHEKNILvcNVINFGTQIPEENRADIFRRFVKGNQGMGTESGGTGLGLSIAR 351
Cdd:cd16952 1 LRSAFSNLVSNAVKYTPPSDTITVRWSQEESGARL--SVEDTGPGIPPEHIPRLTERFYRVDIERCRNTGGTGLGLAIVK 78
|
....*..
gi 1447491076 352 wAALLHH 358
Cdd:cd16952 79 -HVMSRH 84
|
|
| PRK10618 |
PRK10618 |
phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional |
140-325 |
2.67e-05 |
|
phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional
Pssm-ID: 236726 [Multi-domain] Cd Length: 894 Bit Score: 46.46 E-value: 2.67e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447491076 140 KLTLAfnemAEELEHADNMRRDLIANVSHELRTPVSALQAMVENLADGVVEPTPSNM-EAIVNQTHKLADLITFLLDLSR 218
Cdd:PRK10618 435 KLQQA----QREYEKNQQARKAFLQNIGDELKQPLQSLAQLAAQLRQTSDEEQQQPElDQLAEQSDVLVRLVDNIQLLNM 510
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447491076 219 VEAGAESLVITSFDFKDFINNIVETV--KIADAGHNHSISLNIENNIMLVGDKNRLSQlftnVVSNAIKHSADNT---KI 293
Cdd:PRK10618 511 LETQDWKPEQELFSLQDLIDEVLPEVlpAIKRKGLQLLIHNHLKAEQLRIGDRDALRK----ILLLLLNYAITTTaygKI 586
|
170 180 190
....*....|....*....|....*....|...
gi 1447491076 294 -LISAKSNHEKNILVCNVINFGTQIPEENRADI 325
Cdd:PRK10618 587 tLEVDQDESSPDRLTIRILDTGAGVSIKELDNL 619
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|
| HATPase_CreC-like |
cd16945 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
272-370 |
2.94e-05 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.
Pssm-ID: 340421 [Multi-domain] Cd Length: 106 Bit Score: 42.83 E-value: 2.94e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447491076 272 LSQLFTNVVSNAIKHSADNTKILISAKSNHEKNILVcnVINFGTQIPEENRADIFRRFV---KGNQGMGTesggTGLGLS 348
Cdd:cd16945 5 LRQAINNLLDNAIDFSPEGGLIALQLEADTEGIELL--VFDEGSGIPDYALNRVFERFYslpRPHSGQKS----TGLGLA 78
|
90 100
....*....|....*....|..
gi 1447491076 349 IARWAALLHHGNIRVVDDKRGV 370
Cdd:cd16945 79 FVQEVAQLHGGRITLRNRPDGV 100
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| HATPase_NtrY-like |
cd16944 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
268-377 |
1.19e-04 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.
Pssm-ID: 340420 [Multi-domain] Cd Length: 108 Bit Score: 40.98 E-value: 1.19e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447491076 268 DKNRLSQLFTNVVSNAIK----HSADNTKILISAKSNHEKNILVcNVINFGTQIPEENRADIFRRFVKgnqgmgTESGGT 343
Cdd:cd16944 1 DTTQISQVLTNILKNAAEaiegRPSDVGEVRIRVEADQDGRIVL-IVCDNGKGFPREMRHRATEPYVT------TRPKGT 73
|
90 100 110
....*....|....*....|....*....|....*
gi 1447491076 344 GLGLSIARWAALLHHGNIRVVD-DKRGVNFEITLP 377
Cdd:cd16944 74 GLGLAIVKKIMEEHGGRISLSNrEAGGACIRIILP 108
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|
| COG3920 |
COG3920 |
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ... |
224-379 |
9.49e-04 |
|
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];
Pssm-ID: 443125 [Multi-domain] Cd Length: 495 Bit Score: 41.04 E-value: 9.49e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447491076 224 ESLVITSFDFKDFINNIVETVKIADAGHNHSISLNIEnNIMLVGDK-NRLSQLFTNVVSNAIKH---SADNTKILISAKs 299
Cdd:COG3920 352 QSEDWEGVDLRDYLRELLEPLRDSYGGRGIRIELDGP-DVELPADAaVPLGLILNELVTNALKHaflSGEGGRIRVSWR- 429
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447491076 300 nHEKNILVCNVINFGTQIPEENRADifrrfvkgnqgmgtesGGTGLGLSIARwaALLH--HGNIRvVDDKRGVNFEITLP 377
Cdd:COG3920 430 -REDGRLRLTVSDNGVGLPEDVDPP----------------ARKGLGLRLIR--ALVRqlGGTLE-LDRPEGTRVRITFP 489
|
..
gi 1447491076 378 LT 379
Cdd:COG3920 490 LA 491
|
|
| TM_PBP1_LivH_like |
cd06582 |
Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two ... |
65-111 |
2.59e-03 |
|
Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of branched-chain amino acids (AAs). These types of transporters generally bind type 1 PBPs. PBP-dependent ABC transporters consist of a PBP, two TMs, and two cytoplasmic ABCs, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP, which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. E. coli LivH forms a heterodimer with another TM, LivM, to generate the transmembrane pore. LivM is not included in this subgroup. The LIV-1/LS transporter is comprised of two TMs (LivM and LivH), two ABCs (LivG and LivF), and one of two alternative PBPs, LivJ (LIV-BP) or LivK (LS-BP). In addition to transporting branched-chain AAs including leucine, isoleucine and valine, the E. coli LIV-1/LS transporter is involved in the uptake of the aromatic AA, phenylalanine.
Pssm-ID: 119324 [Multi-domain] Cd Length: 272 Bit Score: 39.34 E-value: 2.59e-03
10 20 30 40
....*....|....*....|....*....|....*....|....*..
gi 1447491076 65 FATAIAFVMAWFLLKVGLSGWIAMPLTLAVALGITYAFSRGLTSPLR 111
Cdd:cd06582 32 FYMLGAYVAYTLLVALGLPFWLALLLALLVAALLGVLLERLVLRPLR 78
|
|
| HATPase_HupT_MifS-like |
cd16976 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
272-363 |
4.31e-03 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.
Pssm-ID: 340435 [Multi-domain] Cd Length: 102 Bit Score: 36.28 E-value: 4.31e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447491076 272 LSQLFTNVVSNAIK--HSADNTKILISAKSNHEKNILVcnVINFGTQIPEENRADIFRRFVKgNQGMGTesgGTGLGLSI 349
Cdd:cd16976 1 IQQVLMNLLQNALDamGKVENPRIRIAARRLGGRLVLV--VRDNGPGIAEEHLSRVFDPFFT-TKPVGK---GTGLGLSI 74
|
90
....*....|....
gi 1447491076 350 ARWAALLHHGNIRV 363
Cdd:cd16976 75 SYGIVEEHGGRLSV 88
|
|
| LivH |
COG0559 |
Branched-chain amino acid ABC-type transport system, permease component [Amino acid transport ... |
65-111 |
6.40e-03 |
|
Branched-chain amino acid ABC-type transport system, permease component [Amino acid transport and metabolism];
Pssm-ID: 440325 [Multi-domain] Cd Length: 290 Bit Score: 38.12 E-value: 6.40e-03
10 20 30 40
....*....|....*....|....*....|....*....|....*..
gi 1447491076 65 FATAIAFVMAWFLLKVGLSGWIAMPLTLAVALGITYAFSRGLTSPLR 111
Cdd:COG0559 42 FVMLGAYVAYTLATLLGLPLWLALLLAVLVAALLGVLLERLVIRPLR 88
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