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Conserved domains on  [gi|1452189782|ref|WP_116330079|]
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head-tail connector protein [Enterobacter hormaechei]

Protein Classification

head-tail connector protein( domain architecture ID 10169104)

phage gp6-like head-tail connector protein is critical in the assembly of the connector, a specialized phage structure that serves as an interface for head and tail attachment, as well as a point at which DNA exits the head during infection by the bacteriophage

Gene Ontology:  GO:0016032
PubMed:  19895817

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
gp6 cd08054
Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; The bacteriophage ...
 6-103 6.13e-15

Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; The bacteriophage HK97 gp6 protein is critical in the assembly of the connector, a specialized structure that serves as an interface for head and tail attachment, as well as a point at which DNA exits the head during infection by the bacteriophage. It forms a dodecameric ring structure that comprises the middle ring of the connector, located between the portal protein (attached to the head) and the gp7 ring (attached to the tail). It is a component of the mature phage and the absence of HK97 gp6 results in defective head-tail joining and the absence of mature phage particles. Although the crystal structure of HK97 gp6 shows an unexpected 13-mer ring, the biological form present in the mature phage is believed to be a dodecamer.


:

Pssm-ID: 153446  Cd Length: 91  Bit Score: 64.25  E-value: 6.13e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452189782   6 TLEEVKEHCRIDGDYSDNDLAGKIRAASSAIIRFCQGSRDKIVDAnnrplESEEYSLAKEATLRLVTKLYRDPDGTTmrD 85
Cdd:cd08054     1 TLEEAKAHLRIDHDDDDALIELLIDAAEEYIENYTGRDLDEQTAD-----AEEVPALIKLAVLLLVAHLYENREAVT--D 73

                          90
                  ....*....|....*...
gi 1452189782  86 LKQGELPFDVTMLIWDLR 103
Cdd:cd08054    74 VTASELPFGVESLLAPYR 91
 
Name Accession Description Interval E-value
gp6 cd08054
Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; The bacteriophage ...
 6-103 6.13e-15

Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; The bacteriophage HK97 gp6 protein is critical in the assembly of the connector, a specialized structure that serves as an interface for head and tail attachment, as well as a point at which DNA exits the head during infection by the bacteriophage. It forms a dodecameric ring structure that comprises the middle ring of the connector, located between the portal protein (attached to the head) and the gp7 ring (attached to the tail). It is a component of the mature phage and the absence of HK97 gp6 results in defective head-tail joining and the absence of mature phage particles. Although the crystal structure of HK97 gp6 shows an unexpected 13-mer ring, the biological form present in the mature phage is believed to be a dodecamer.


Pssm-ID: 153446  Cd Length: 91  Bit Score: 64.25  E-value: 6.13e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452189782   6 TLEEVKEHCRIDGDYSDNDLAGKIRAASSAIIRFCQGSRDKIVDAnnrplESEEYSLAKEATLRLVTKLYRDPDGTTmrD 85
Cdd:cd08054     1 TLEEAKAHLRIDHDDDDALIELLIDAAEEYIENYTGRDLDEQTAD-----AEEVPALIKLAVLLLVAHLYENREAVT--D 73

                          90
                  ....*....|....*...
gi 1452189782  86 LKQGELPFDVTMLIWDLR 103
Cdd:cd08054    74 VTASELPFGVESLLAPYR 91
put_DNA_pack TIGR01560
uncharacterized phage protein (possible DNA packaging); This model describes a small (~ 100 ...
 6-104 1.90e-05

uncharacterized phage protein (possible DNA packaging); This model describes a small (~ 100 amino acids) protein found in phage and in putative prophage regions of a number of bacterial genomes. Members have been annotated in some cases as a possible DNA packaging protein, but the source of this annotation was not traced during construction of this model. [Mobile and extrachromosomal element functions, Prophage functions]


Pssm-ID: 130623  Cd Length: 91  Bit Score: 40.06  E-value: 1.90e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452189782   6 TLEEVKEHCRIDGDySDNDLAGKIRAASSAIIRFCQGSRDKIVDannrplesEEYSLAKEATLRLVTKLYRDPDGTTMRD 85
Cdd:TIGR01560   1 TLDEVKLSLRIDHD-DDDELIKLMIAAAQDYIQSAIGTGVKDSF--------DSKPLFKLACIKLVAHYYENRGLYADRA 71

                          90
                  ....*....|....*....
gi 1452189782  86 LKQgeLPFDVTMLIWDLRL 104
Cdd:TIGR01560  72 LVN--VPIMVNALIHQLRG 88
Phage_connect_1 pfam05135
Phage gp6-like head-tail connector protein; This family of proteins contain head-tail ...
 5-82 4.97e-05

Phage gp6-like head-tail connector protein; This family of proteins contain head-tail connector proteins related to gp6 from bacteriophage HK97. A structure of this protein shows similarity to gp15 a well characterized connector component of bacteriophage SPP1.


Pssm-ID: 428326  Cd Length: 93  Bit Score: 38.93  E-value: 4.97e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452189782   5 VTLEEVKEHCRIDGDYSDNDLAGKIRAASSAIIRFCqgsRDKIVDANNRPLESEeyslAKEATLRLVTKLY--RDPDGTT 82
Cdd:pfam05135   2 ITLEDIKTLLGIDDDSDDALLNSYIDAAEEYIENYL---GRSLGDPDAISLPAD----LKYAVLELAVARYnnRGNEGMS 74
 
Name Accession Description Interval E-value
gp6 cd08054
Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; The bacteriophage ...
 6-103 6.13e-15

Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; The bacteriophage HK97 gp6 protein is critical in the assembly of the connector, a specialized structure that serves as an interface for head and tail attachment, as well as a point at which DNA exits the head during infection by the bacteriophage. It forms a dodecameric ring structure that comprises the middle ring of the connector, located between the portal protein (attached to the head) and the gp7 ring (attached to the tail). It is a component of the mature phage and the absence of HK97 gp6 results in defective head-tail joining and the absence of mature phage particles. Although the crystal structure of HK97 gp6 shows an unexpected 13-mer ring, the biological form present in the mature phage is believed to be a dodecamer.


Pssm-ID: 153446  Cd Length: 91  Bit Score: 64.25  E-value: 6.13e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452189782   6 TLEEVKEHCRIDGDYSDNDLAGKIRAASSAIIRFCQGSRDKIVDAnnrplESEEYSLAKEATLRLVTKLYRDPDGTTmrD 85
Cdd:cd08054     1 TLEEAKAHLRIDHDDDDALIELLIDAAEEYIENYTGRDLDEQTAD-----AEEVPALIKLAVLLLVAHLYENREAVT--D 73

                          90
                  ....*....|....*...
gi 1452189782  86 LKQGELPFDVTMLIWDLR 103
Cdd:cd08054    74 VTASELPFGVESLLAPYR 91
put_DNA_pack TIGR01560
uncharacterized phage protein (possible DNA packaging); This model describes a small (~ 100 ...
 6-104 1.90e-05

uncharacterized phage protein (possible DNA packaging); This model describes a small (~ 100 amino acids) protein found in phage and in putative prophage regions of a number of bacterial genomes. Members have been annotated in some cases as a possible DNA packaging protein, but the source of this annotation was not traced during construction of this model. [Mobile and extrachromosomal element functions, Prophage functions]


Pssm-ID: 130623  Cd Length: 91  Bit Score: 40.06  E-value: 1.90e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452189782   6 TLEEVKEHCRIDGDySDNDLAGKIRAASSAIIRFCQGSRDKIVDannrplesEEYSLAKEATLRLVTKLYRDPDGTTMRD 85
Cdd:TIGR01560   1 TLDEVKLSLRIDHD-DDDELIKLMIAAAQDYIQSAIGTGVKDSF--------DSKPLFKLACIKLVAHYYENRGLYADRA 71

                          90
                  ....*....|....*....
gi 1452189782  86 LKQgeLPFDVTMLIWDLRL 104
Cdd:TIGR01560  72 LVN--VPIMVNALIHQLRG 88
Phage_connect_1 pfam05135
Phage gp6-like head-tail connector protein; This family of proteins contain head-tail ...
 5-82 4.97e-05

Phage gp6-like head-tail connector protein; This family of proteins contain head-tail connector proteins related to gp6 from bacteriophage HK97. A structure of this protein shows similarity to gp15 a well characterized connector component of bacteriophage SPP1.


Pssm-ID: 428326  Cd Length: 93  Bit Score: 38.93  E-value: 4.97e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452189782   5 VTLEEVKEHCRIDGDYSDNDLAGKIRAASSAIIRFCqgsRDKIVDANNRPLESEeyslAKEATLRLVTKLY--RDPDGTT 82
Cdd:pfam05135   2 ITLEDIKTLLGIDDDSDDALLNSYIDAAEEYIENYL---GRSLGDPDAISLPAD----LKYAVLELAVARYnnRGNEGMS 74
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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