|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
8-388 |
1.99e-56 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 190.13 E-value: 1.99e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452215840 8 RTIILSRVLLQFGIWIRNYAVLLFVSELTNNnPVYVSLISVAEFAPIFLFGLIGGTFADRWRPKRTMVWSDLLSALSVGA 87
Cdd:cd06173 2 RLLWLAQLLSALGDWIFTVALPWLVLQLTGS-ALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452215840 88 VLLALMNGG--WIALLIGTFISASLSQFSQPSAMKLYKRHVQVEQLQGVMAMSQTLVAVFMVLGPVIGTFIFIQFGINAS 165
Cdd:cd06173 81 LALLALLGSlsLWLLLVLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452215840 166 LILTVVLFLGSSLVLATLPRDAEEPKSGDAGGFIKELKAGLRYIGSNQSLRTLCLTFSAVGLASGLTQPLQIFLVIENLG 245
Cdd:cd06173 161 FAINALSFLLSALLLLFIRRPPPAAPGESSSLLLRDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLG 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452215840 246 QDKQFLQWLVMTNGAAMLAGGAVMIGISKKVKPQLLLMLGLLVTAVCTIGIGASTMIWLTIILLVISGFFFPCIQGGIQT 325
Cdd:cd06173 241 GGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNT 320
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1452215840 326 LIVRNTEGAFIGRVSGAIMPVFMGMMVIGMFISGYLKNTVSLVAVYVMSGVLIIIGASFLFPL 388
Cdd:cd06173 321 LLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLLLL 383
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
30-386 |
1.48e-19 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 89.56 E-value: 1.48e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452215840 30 LFVSELtNNNPVYVSLISVAEFAPIFLFGLIGGTFADRWRPKRTMVWSDLLSALSVGAVLLAlmnGGWIALLIGTFISAS 109
Cdd:cd17325 21 LYAESL-GASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFA---TSYWQLLLARFLQGL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452215840 110 LSQFSQPSAMKLYKRHVQVEQLQGVMAMSQTLVAVFMVLGPVIGTFIFIQFGINAS-LILTVVLFLGSSLVLATLPRDAE 188
Cdd:cd17325 97 ASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPfLVCAALALLALVLALLLLPEPRP 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452215840 189 EPKSGDAGGFIKelKAGLRYIGSNQSLRTLCLTFSAVGLASGLTQPLQIFLVIENLGQDKQFLQWLVMTNGAAMLAGGAV 268
Cdd:cd17325 177 PPNKRAVSAARL--RSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPP 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452215840 269 MIGISKKVKPQLLLMLGLLVTAVCTIGIGASTMIWLTIILLVISGFFFPCIQGGIQTLIVRNTEGAFIGRVSGAIMPVFM 348
Cdd:cd17325 255 AGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFS 334
|
330 340 350
....*....|....*....|....*....|....*...
gi 1452215840 349 GMMVIGMFISGYLKNTVSLVAVYVMSGVLIIIGASFLF 386
Cdd:cd17325 335 LGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFL 372
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
7-351 |
2.03e-19 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 88.49 E-value: 2.03e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452215840 7 VRTIILSRVLLQFGIWIRNYAVLLFVSELtNNNPVYVSLISVAEFAPIFLFGLIGGTFADRWRPKRTMVWSDLLSALSVG 86
Cdd:COG2814 12 LLALALGAFLSGLGIGIVLPALPLIAADL-GASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452215840 87 AVLLAlmnGGWIALLIGTFISASLSQFSQPSAMKLYKRHVQVEQLQGVMAMSQTLVAVFMVLGPVIGTFIFIQFGINASL 166
Cdd:COG2814 91 LCALA---PSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVF 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452215840 167 ILTVVLFLGSSLVLATLPRDAEEPKSGDAGGFIKELKaglryigSNQSLRTLCLTFSAVGLASGLTQPLQIFLVIENLGQ 246
Cdd:COG2814 168 LVNAVLALLALLLLLRLLPESRPAARARLRGSLRELL-------RRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452215840 247 DKQFLQWLVMTNGAAMLAGGAVMIGISKKVKPQLLLMLGLLVTAVCTIGIGASTMIWLTIILLVISGFFFPCIQGGIQTL 326
Cdd:COG2814 241 SASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQAL 320
|
330 340
....*....|....*....|....*
gi 1452215840 327 IVRNTEGAFIGRVSGAIMPVFMGMM 351
Cdd:COG2814 321 VAELAPPEARGRASGLYNSAFFLGG 345
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
10-355 |
4.32e-18 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 84.78 E-value: 4.32e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452215840 10 IILSRVLLQFGIWIRNYAVLLFVSELTNNNPVYVSLISVAEFAPIFLFGLIGGTFADRWRPKRTMVWSDLLSALsvgAVL 89
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFAL---GLL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452215840 90 LALMNGGWIALLIGTFISASLSQFSQPSAMKLYKRHVQVEQLQGVMAMSQTLVAVFMVLGPVIGTFIFIQFGINASLILT 169
Cdd:pfam07690 78 LLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLIL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452215840 170 VVLFLGSSLVLATLPRDAEEPKSGDAGGFIKELKAGLRYIGSNQSLRTLCLTFSAVGLASGLTQPLQIFLVIenLGQDKQ 249
Cdd:pfam07690 158 AILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEV--LGLSAL 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452215840 250 FLQWLVMTNGAAMLAGGAVMIGISKKVKPQLLLMLGLLVTAVCTIGI---GASTMIWLTIILLVISGFFFPCIQGGIQTL 326
Cdd:pfam07690 236 LAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLlllSLTLSSLWLLLALLLLGFGFGLVFPALNAL 315
|
330 340
....*....|....*....|....*....
gi 1452215840 327 IVRNTEGAFIGRVSGAIMPVFMGMMVIGM 355
Cdd:pfam07690 316 VSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_3 |
pfam05977 |
Transmembrane secretion effector; This is a family of transport proteins. Members of this ... |
2-404 |
4.77e-15 |
|
Transmembrane secretion effector; This is a family of transport proteins. Members of this family include a protein responsible for the secretion of the ferric chelator, enterobactin, and a protein involved in antibiotic resistance.
Pssm-ID: 399164 [Multi-domain] Cd Length: 523 Bit Score: 76.71 E-value: 4.77e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452215840 2 FSNRYVRTIILSRVLLQFGIWIRNYAVLLFVSELTNNnPVYVSLISVAEFAPIFLFGLIGGTFADRWRPKRTMVWSDLLS 81
Cdd:pfam05977 7 LRQGVFRVIWIASLASNLGTLMQDVAASWLMTSLSAS-PLMVALVQAAATLPIFLLSIPAGALADNFDRRKIMLAGQLLL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452215840 82 AL-SVGAVLLALMNGGWIALLIG-TFISASLSQFSQPSAMKLYKRHVQVEQLQGVMAMSQTLVAVFMVLGPVIGTFIFIQ 159
Cdd:pfam05977 86 ALvSTLLTLLAGLGLLSPWLLLGlTFLGGIGTALMDPAWQASVPELVPRRDLPAAVALNSVGYNIARSVGPALGGVLLAA 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452215840 160 FGINASLILTVVLFLGSSLVLATLPRDAeEPKSGDAGGFIKELKAGLRYIGSNQSLRTLCLTFSAVGLASGLTQPLQIFL 239
Cdd:pfam05977 166 FGPAFTFALNALSYFAVIAALWRWKRAA-PASPLPRERIFGAVRAGLRFTAMSRELRSVLVRAFAFGLSASAVWALLPLV 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452215840 240 VIENLGQDKQFLQWLVMTNGAAMLAGGAVMIGISKKVKPQLLLMLGLLVTAVCTIGIGASTMIWLTIILLVISGFFFPCI 319
Cdd:pfam05977 245 ARDLLDGDAIFYGILLGAVGVGAILGALSLPRLRERLGSDRLVLLASVVTALVLLSLALAPNLWLAIPVLLLGGAAWITA 324
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452215840 320 QGGIQTLIVRNTEGAFIGRVSGAIMPVFMGMMVIGMFISGYLKNTVSLVAVYVMSGVLIIIGA--SFLFPLMVQKRSKMR 397
Cdd:pfam05977 325 LTTLNVAVQLSVPRWVRGRALAVYQTVFFGGMAAGSWLWGAVAEALSVTGALLGAAAALLAGAaaGLRFRLPEGEAADLI 404
|
....*..
gi 1452215840 398 NAQHYDE 404
Cdd:pfam05977 405 PSNHWPE 411
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
26-386 |
1.13e-13 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 72.07 E-value: 1.13e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452215840 26 YAVLLFVSELTNNNPVYVSLISVAEFAPIFLFGLIGGTFADRWRPKRTMVWSDLLsaLSVGAVLLALMNGGWIaLLIGTF 105
Cdd:cd06174 16 SPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLL--FALGALLFAFAPSFWL-LLLGRF 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452215840 106 ISASLSQFSQPSAMKLYKRHVQVEQLQGVMAMSQTLVAVFMVLGPVIGTFIFIQFGIN---ASLILTVVLFLGSSLVLAT 182
Cdd:cd06174 93 LLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGwraVFLIAAALALLAAILLLLV 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452215840 183 LPRDAEEPKSGDAGGFIKELKAGLRYIGSNQSLRTLCLTFSAVGLASGLTQPLQIFLVIENLGQDKQFLQWLVMTNGAAM 262
Cdd:cd06174 173 VPDPPESARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAG 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452215840 263 LAGGAVMIGISKKVKPQ-LLLMLGLLVTAVCTIGIGASTMIWLTIILLVISGFFFPCIQGGIQTLIVRNTEGAFIGRVSG 341
Cdd:cd06174 253 ALGSLLLGLLSDRLIGRkPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFG 332
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 1452215840 342 AIMPVFMGMMVIGMFISGYLKNTV-SLVAVYVMSGVLIIIGASFLF 386
Cdd:cd06174 333 LLNTFGFLGGAIGPLLAGFLLAATfGLTGAFLVLAVLLLLAAILLL 378
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
39-395 |
8.51e-12 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 66.03 E-value: 8.51e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452215840 39 NPVYVSLISVAEFAPIFLFGLIGGTFADRWRPKRTMVWSDLLSAlsVGAVLLALMnGGWIALLIGTFISASLSQFSQpSA 118
Cdd:COG0738 41 SDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMA--LGLLLFALA-PSYPLLLLALFLLGLGLGLLD-VA 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452215840 119 MKLYKRHVQVEQLQGVMAMSQTLVAVFMVLGPVIGTFiFIQFGINASLILTVVLFLGSSLVLATLPRDAEEPKSGDAGGF 198
Cdd:COG0738 117 ANPYVAALGPETAASRLNLLHAFFSLGALLGPLLGGL-LILLGLSLSWHLPYLILAVLLLLLALLFLRSKLPEIEEEEEE 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452215840 199 IKELKAGLRYIGSNQSLRTLCLTFSAVGLASGLTQPLQIFLVIENLGQDKQFLQWLVMTNGAAMLAGGAVMIGISKKVKP 278
Cdd:COG0738 196 AAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGP 275
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452215840 279 QLLLMLGLLVTAVCTIGIGASTMIWLTIILLVISGFFFPCIQGGIQTLIVRNtegafIGRVSGAIMPVFMGMMVIGMFIS 358
Cdd:COG0738 276 VRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLSLMFPTIFSLALDG-----LGKRTAAAVSAVLIMGIVGGAIG 350
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 1452215840 359 ----GYLKNTVSLVAVYVMSGVLIIIGASFLFPLMVQKRSK 395
Cdd:COG0738 351 ppliGFLADAFGLRAAFLVPLVCYLLILLLALALKRKRRKK 391
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
44-393 |
7.59e-10 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 59.88 E-value: 7.59e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452215840 44 SLISVAEFAPIFLFGLIGGTFADRWRPKRTMVWSdlLSALSVGAVLLALMNGGWIALLIGTFISASLSqFSQPSAMKLYK 123
Cdd:COG2271 48 GLLASAFFLGYALGQIPAGLLADRFGRRRVLAIG--LLLWGLATLLFGFATSFWQLLLLRFLLGLGEA-GFFPAALKLIA 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452215840 124 RHVQVEQLQGVMAMSQTLVAVFMVLGPVIGTFIFIQFGINASLILTVVLFLGSSLVlatlprdaeepksgdaggfikelk 203
Cdd:COG2271 125 EWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLILGLPGLLLALL------------------------ 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452215840 204 aglryigsnqSLRTLCLTFSAVGLASGLTQPLQIFLVIENLGQDKQFLQWLVMTNGAAMLAGGAVMIGISKKV--KPQLL 281
Cdd:COG2271 181 ----------RFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLgrRRKLV 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452215840 282 LMLGLLVTAVCTIGIGASTMIWLTIILLVISGFFFPCIQGGIQTLIVRNTEGAFIGRVSGAIMPVFMGMMVIGMFISGYL 361
Cdd:COG2271 251 LAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYL 330
|
330 340 350
....*....|....*....|....*....|..
gi 1452215840 362 KNTVSLVAVYVMSGVLIIIGASFLFPLMVQKR 393
Cdd:COG2271 331 LDATGYQAAFLLLAALALLAALLALLLLRETR 362
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
1-181 |
1.21e-09 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 59.51 E-value: 1.21e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452215840 1 MFSNRYVRTIILSRVLLQFGIWIRNYAVLLFVSELTNNNPVYVSLISVAEFAPIFLFGLIGGTFADRWRPKRTMVWSDLL 80
Cdd:cd17325 195 LLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLL 274
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452215840 81 SALSVgaVLLALMNGGWIALLIGTFISASLSqFSQPSAMKLYKRHVQVEQLQGVMAMSQTLVAVFMVLGPVIGTFIFIQF 160
Cdd:cd17325 275 SAVAL--LLLPLATSFWLLLLLLALLGLGLG-LVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAF 351
|
170 180
....*....|....*....|.
gi 1452215840 161 GINASLILTVVLFLGSSLVLA 181
Cdd:cd17325 352 GFATPFLAAAALLLLAAVLFL 372
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
134-361 |
3.51e-08 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 55.29 E-value: 3.51e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452215840 134 VMAMSQTLVAVFMVLGPVIGTFIFIQFGIN-------ASLILTVVLFLGSSLVLATLPRDAEEPKSGdaggfiKELKAGL 206
Cdd:COG2211 148 LSSWRFAFAGLGGLLASVLPPPLVAAFGGDaalgyrlTALIFAVLGLLAFLLTFFGTKERPVPEEEK------VSLKESL 221
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452215840 207 RYIGSNQSLRTLCLTFSAVGLASGLTQPLQIFLVIENLGQDKQFLQWLVMTNGAAMLAGGAVMIGISKKVKPQLLLMLGL 286
Cdd:COG2211 222 KALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGL 301
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452215840 287 LVTAVCTIGIGASTM--IWLTIILLVISGFFFPCIQGGIQTLI---VRNTEGAFIGRVSGAIMPVFMGMMVIGMFISGYL 361
Cdd:COG2211 302 LLAALGLLLLFFLGPgnLWLLLVLAALAGIGLGAILVLPWAMLadvVDYDEWKTGRRREGLYFGIFTFAIKLGQALAGAL 381
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
56-386 |
9.25e-08 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 53.71 E-value: 9.25e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452215840 56 LFGLIGGTFADRWRPKRTMVWSDLLSALSVgavLLALMNGGWIALLIGTFISASLSQFSQPSAMKLYKRHVQVEQLQGVM 135
Cdd:cd17324 49 LGALLLGPLSDRIERRRLLLVLLLLFILGN---LLAALAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAI 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452215840 136 AMSQTLVAVFMVLGPVIGTFIFIQFGINAS-LILTVVLFLGSSLVLATLPRDAEEPKSGdaggfIKELKAGLRYIGSNQS 214
Cdd:cd17324 126 GLVFSGLTLGLVLGRPLGGLLGQLLGWRAAfLAIAVLALLAALLLWRLLPSLPPKKPGS-----LGLLSSLLLLLRNPRL 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452215840 215 LRTLCLTFSAVGLASGLTQPLQIFLvIENLGQDKQFLQWLVMTNGAAMLAGGAVMIGISKKVKPQLLLMLGLLVTAVCTI 294
Cdd:cd17324 201 RLAYLITFLLFGGFFALYTYLAPFL-TDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLL 279
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452215840 295 GIGASTMIWLTIILLVISGFFFPCIQGGIQTLIVRNTEGAfIGRVSGAIMPVFMGMMVIGMFISGYLKNTVSLVAVYVMS 374
Cdd:cd17324 280 LTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPEA-RGLASSLYLAAYNLGGALGAALGGLVLDHGGWAGVGWVG 358
|
330
....*....|..
gi 1452215840 375 GVLIIIGASFLF 386
Cdd:cd17324 359 AALLLLALLLAL 370
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
55-382 |
3.42e-07 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 51.84 E-value: 3.42e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452215840 55 FLFGLIGGTFADRWRPKRTMVWSDLLSALsvGAVLLALMNGGW--IALLIGTFISASLSQ-FSQPSAMKLYKRhvqvEQL 131
Cdd:cd17329 49 IVASLIGGRLADRFGRKPVMLAGLLLRAL--GFALLGFAHSPWlfAIALVLTGFGGGLFEpASEAMIADVTTP----ENR 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452215840 132 QGVMAMSQTLVAVFMVLGPVIGTFIFIQFGINASLILTVVLFLGSSLVLATLPRDAEEPKSGDAGGFIKELKAGLRyigs 211
Cdd:cd17329 123 TRAFSLLYWAINLGVAIGPLLGGLLLLYSFRLLFLAAAVLFLLAALVLLFLLPETRPKRRAAEKTEILRGYKIVLR---- 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452215840 212 NQSLRTLCLTFSAVGLASGLTQP-LQIFLVIENLGQDKQfLQWLVMTNGAAMLAGGAVMIGISKKVKPQLLLMLGLLVTA 290
Cdd:cd17329 199 DRAFLLFLLASFLISLIYFQLEStLPVYVVEILGLGESL-LGLLLALNALLIVLLQFPVARLVERFRLRKILMIGILLFA 277
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452215840 291 VCTIGIGASTMIWLTIILLVI----SGFFFPciqgGIQTLIVRNTEGAFIGRVSGAIMPVFMGMMVIGMFISGYLKNTVS 366
Cdd:cd17329 278 IGFAVLAFANTLAVLILAMIVltlgEMLVFP----AVQTLVAALAPPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLG 353
|
330
....*....|....*.
gi 1452215840 367 LVAVYVMSGVLIIIGA 382
Cdd:cd17329 354 PGLPWLILAALGLIAA 369
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
10-384 |
5.82e-07 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 51.06 E-value: 5.82e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452215840 10 IILSRVLLQFGIWIRNYAVLLFVSELTNNNPVYVSLISVAEFAPIFLFGLIGGtFADRWRPKRTMVWSDLLSALSVGAVL 89
Cdd:cd17489 1 ILLANFFFFLSFYLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGR-LLDRFGRKRLLLIGLLIFALATLLYL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452215840 90 LAlmnGGWIALLIGTFISASLSQFSQPSAMKLYKRHVQVEQLQGVMAMSQTLVAVFMVLGPVIGTFIFIQFGINASLILT 169
Cdd:cd17489 80 LA---TSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVA 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452215840 170 VVLFLGSSLVLATLPRDAEEPKSGDAGGFIKELKAGLRYIgsnqSLRTLCLTFSAVGLASGLTqplqiFLVI--ENLGQD 247
Cdd:cd17489 157 AVLALLALLLVFLVKDPPPVAAEEAEAGTRAFRRLVEKKV----LPPALILFLASIAYGAIST-----FLPLyaAERGIS 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452215840 248 KqflQWLVMTNGAAMLAGGAVMIG-ISKKVKPQLLLMLGLLVTAVCTIGIGASTMIWLTIILLVISGFFFPCIQGGIQTL 326
Cdd:cd17489 228 N---AGLFFTVYAIALLLSRPFSGkLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQAL 304
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 1452215840 327 IVRNTEGAFIGRVSGAIMPVFMGMMVIGMFISGYLKNTVSLVAVYVMSGVLIIIGASF 384
Cdd:cd17489 305 AVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLALVL 362
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
62-386 |
4.42e-06 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 48.32 E-value: 4.42e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452215840 62 GTFADRWRPKRTMVWSDLLSALsvGAVLLALMNGGWIALLIGTFISASLSQFsQPSAMKLykrhvqVEQLQGV---MAMS 138
Cdd:cd17478 52 GYLADRKPRRYLLPLGPLLTGL--GLSLLGFAPNYWLLLLLVALAGIGSAAF-HPEGARL------ASQAAGGrrgLAMS 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452215840 139 qtlvaVFMV-------LGPVIGTFIFIQFGINASLILTVVLFLGSSLVLATLPRDAEEPKSGDAggfiKELKAGLRYIGS 211
Cdd:cd17478 123 -----IFSVggnlgfaLGPLIAAALVALFGGLGLLILLIIPGLAVALLLLRLRPLKKPEAKKAA----AKSSARSTLKGV 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452215840 212 NQSLRTLCLTFSAVGLA-SGLTQPLQIFLVieNLGQDKQFLQWLVmtngAAMLAGGAV--MIG--ISKKVKPQLLLMLGL 286
Cdd:cd17478 194 WRALLLLLIIVFLRSWVlSSLTTFLPFYLV--QRGYSLVFAGLLL----SLFLFAGAIgtLIGgpLSDRFGRRRVIIASL 267
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452215840 287 LVTAVCTIGIgASTMIWLTIILLVISGFF----FPCIQGGIQTLIVRNtegafIGRVSGAIMPVFMGMMVIGMFISGYLK 362
Cdd:cd17478 268 LLAAPFLLLF-LLTPGIWSYILLVLAGFLlfasFPVTVVLAQELLPGN-----VGLASGLMMGLSFGLGGIGAPVLGALA 341
|
330 340
....*....|....*....|....
gi 1452215840 363 NTVSLVAVYVMSGVLIIIGASFLF 386
Cdd:cd17478 342 DAFGLESVLLILALLPLLGALLAF 365
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
43-396 |
8.54e-06 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 47.57 E-value: 8.54e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452215840 43 VSLISVAEFAPIFLFGLIGGTFADRWRPKRTMVWSdlLSALSVGAVLLALMNGGWIALLIGTFISASLSqFSQPSAMKLY 122
Cdd:COG2223 42 LGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIG--LLLLGIGLLLLALAVSYWLLLLLGLLLGIGGG-GSFAVGIALV 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452215840 123 KRHVQVEQLQGVMAMSQTLVAVFMVLGPVIGTFIFIQFGINASLILTVVLFLGSSLVLATLPRDAEEPKSGDAGGFIKEL 202
Cdd:COG2223 119 SKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILGILLLVVAVLAWLFLRDPPAGAAAAAKASLRDQ 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452215840 203 KAGLRyigsNQSLRTLCLTFSAVGLA-SGLTQPLQIFLViENLGQDKQFLQWLVMTNGAAMLAGGAVMIGISKKVKPQLL 281
Cdd:COG2223 199 LEALR----DPRFWLLSLLYFGTFGSfIGFSSWLPPYLV-DQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRV 273
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452215840 282 LMLGLLVTAVCTIGIGASTM-IWLTIILLVISGFFFPCIQGGIQTLIVRNTEGAFIGRVSGAI-MPVFMGMMVIGMFISG 359
Cdd:COG2223 274 LLIVFALMALGLLLLALALGsLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVgAAGGLGGFLGPLLFGA 353
|
330 340 350
....*....|....*....|....*....|....*..
gi 1452215840 360 YLKNTVSLVAVYVMSGVLIIIGASFLFPLMVQKRSKM 396
Cdd:COG2223 354 LLDATGSYTAAFLVFAVLALVALVLTLLLYRRPRRAA 390
|
|
| MFS_SLC22A18 |
cd17331 |
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ... |
58-386 |
1.49e-05 |
|
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 46.83 E-value: 1.49e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452215840 58 GLIGGTFADRWRPKRTMVWSDLLSALSVGavLLALMNGGWIalligTFIS--ASLSQFSQPSAMKLYKRHVQVEQLQGVM 135
Cdd:cd17331 52 GPLFGRFGDLFGPRAALVLSFLSSALSYL--LLAFASSVPM-----LFLSrlPSVFMHAMQAAQMVVTDLTDPGERAAAL 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452215840 136 AMSQTLVAVFMVLGPVIGTFIFIQFGINASLILTVVL-FLGSSLVLATLP------RDAEEPKSGDAGGFIKelKAGLRY 208
Cdd:cd17331 125 GRLGLSYGIGMVVGSFLGGLLTKKFGEQAAALVAAVGsLLSIVLVILLIPsntkskREKEAKESASPPSVFN--LKEILR 202
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452215840 209 IGSNQSLRTLCLTFSAVGLASGLTQPLQIFLVIENLGQDKQFLQWLVMTNGAA-MLAGGAVMIGISKKVKPQLLLMLGLL 287
Cdd:cd17331 203 LLRLPGVAFLLLVKLLSGLPIGMFQSMFSLVAMDFFGLTPEENGYLMSYAGVLgMVVQGLLVGPLTKRFGERSLLKLSVA 282
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452215840 288 VTAVCTIGIGASTMIWLTIILLVISGFFFPCIQGGIQTLIVRNTEGAFIGRVSGAIMPVFMGMMVIGMFISGYLKNTVSL 367
Cdd:cd17331 283 LLAIGYLLLAFVTTVWQLLVLLLPLVIGGSVLYTVITSLLTKAVPPEDTGTALGLSHALFSLVRTVSPTIGGALLQAYGF 362
|
330
....*....|....*....
gi 1452215840 368 VAVYVMSGVLIIIGASFLF 386
Cdd:cd17331 363 PSFGLLGAAINGLLTVYLL 381
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
214-389 |
2.25e-05 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 46.12 E-value: 2.25e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452215840 214 SLRTLCLTFSAVGLASGLTQPLQIFLViENLGQDKQFLQWLVMTNGAAMLAGGAVMIGISKKVKPQLLLMLGLLVTAVCT 293
Cdd:COG2814 11 ALLALALGAFLSGLGIGIVLPALPLIA-ADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGS 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452215840 294 IGIGASTMIWLTIILLVISGFFFPCIQGGIQTLIVRNTEGAFIGRVSGAIMPVFMGMMVIGMFISGYLKNTVSLVAVYVM 373
Cdd:COG2814 90 LLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLV 169
|
170
....*....|....*.
gi 1452215840 374 SGVLIIIGASFLFPLM 389
Cdd:COG2814 170 NAVLALLALLLLLRLL 185
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
62-386 |
2.67e-05 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 46.00 E-value: 2.67e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452215840 62 GTFADRWRPKRTMVWSDLLsALSVGAVLLALMNGGWIALLIG-TFISASLSQFSQPSAM-KLYKRHVQVEQLQGVMAMSQ 139
Cdd:cd17471 53 GRLSDRGGDRKPLILLALL-AGALGYLLFAFLRNYWVLLLVGvVLLSLGAAAFPQLFALaREYADRSSGRDATLFNSVLR 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452215840 140 TLVAVFMVLGPVIGTFIFIQFGINASLILTVVLFLGSSLVLATLPRDAEEPKSgdaggfIKELKAGLRYIGSNQSLRTLC 219
Cdd:cd17471 132 AAFSLAWVIGPPLAFLLLDVLGFTGLFLLAALLYLVVALLVLFLLPSVKPPAQ------KATPASSLVKAPVNRRLLLLF 205
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452215840 220 LTFSAVGLAS---GLTQPLqifLVIENLGQDKQFLQWLVMTNGA----AMLAGGAVmigiSKKVKPQLLLMLGLLVTAVC 292
Cdd:cd17471 206 AAFTLLFAANsmyIIAMPL---YVTNELGGSESWVGLLFGLAAAleipIMLLAGLL----AKRFGKRRLLLAGFLAGVLF 278
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452215840 293 TIGIGASTMIWLTIILLVISGFFFpCIQGGIQTLIVRNTEGAFIGRVSGAIMPVFMGMMVIGMFISGYLKNTVSLVAVYV 372
Cdd:cd17471 279 YLGLALATSLWQLIALQLLNAIFI-GITAGLGISYFQDLMPGQPGLATTLYSNASRIGSLLGGLLAGVIAQYFGYRAVFL 357
|
330
....*....|....
gi 1452215840 373 MSGVLIIIGASFLF 386
Cdd:cd17471 358 VCAVLALLALVLLL 371
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
30-386 |
4.79e-05 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 45.33 E-value: 4.79e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452215840 30 LFVSELTNNNPVYVSLISVAEFAPIFL----FGLIGGTFADRWRPKRTMVWSDLLSALSVGavLLALMNGGW----IALL 101
Cdd:cd17391 21 LYIEQLGVTSGGLVELWSGLAFSSTFLvsaiFSPIWGRLADRYGRKPMLLRASLGMAIVIG--LMAFVTNVWqlliLRLL 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452215840 102 IGTFisaslSQFSqPSAMKLYKRHVQVEQLQGVMAMSQTLVAVFMVLGPVIGTFIFIQFGINASLILTVVLFLGSSLVLA 181
Cdd:cd17391 99 QGVF-----SGYV-PNATALIASQTPKEKSGWALGTLSTGVVAGTLIGPLLGGFLADLFGIRNVFFITGGLLFLAFLLTL 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452215840 182 TLPRDAEEPKSGDAGGFIKELkagLRYIGSNQSLRTLCLTFSAVGLASGLTQPLqIFLVIENLGQDKQ---FLQWLVM-- 256
Cdd:cd17391 173 FFVKEDFKPVEKKKMVSTKEV---WNSVPNPSLLISLFVTTFIIQLANQSIEPI-LTLYIRQLMGDASnlaFISGLVFsa 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452215840 257 TNGAAMLAggAVMIG-ISKKVKPQLLLMLGLLVTAVCTIGIGASTMIWLTIILLVISGFFFPCIQGGIQTLIVRNTEGAF 335
Cdd:cd17391 249 TGVSSLLS--APRLGkLGDRIGHHRILLGALLASALLYIPQAFVQTPWQLGILRFLLGLATGGLLPAINSLLAKITPKEV 326
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 1452215840 336 IGRVSGAIMPVFMGMMVIGMFISGYLKNTVSLVAVYVMSGVLIIIGASFLF 386
Cdd:cd17391 327 AGRIFGYNQSFQYLGNVAGPLLGSAIAAHFGYRAVFVVTALLVLLNAIWSF 377
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
1-184 |
5.43e-05 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 45.28 E-value: 5.43e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452215840 1 MFSNRYVRTIILSRVLLQFGIWIRNYAVLLFVSELTNNNPVYVSLISVAEFAPIFLFGLIGGTFADRWRPKRTMVWSDLL 80
Cdd:COG2211 224 LLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLL 303
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452215840 81 SALSVGAVLLALMNGGWIALLIGTFISASLSqFSQPSAMKLYKRHVQVEQLQ----------GVMAMSQTLVavfMVLGP 150
Cdd:COG2211 304 AALGLLLLFFLGPGNLWLLLVLAALAGIGLG-AILVLPWAMLADVVDYDEWKtgrrreglyfGIFTFAIKLG---QALAG 379
|
170 180 190
....*....|....*....|....*....|....
gi 1452215840 151 VIGTFIFIQFGINASLILTVVLFLGSSLVLATLP 184
Cdd:COG2211 380 ALAGLLLALFGYVAGAAQSPSALTGIRLLFFLLP 413
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
218-386 |
6.36e-05 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 44.72 E-value: 6.36e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452215840 218 LCLTFSAVGLASGLTQPLQIFLVIENLGQDKQFLQWLVMTNGAAMLAGGAVMIGISKKVKPQLLLMLGLLVTAVCTIGIG 297
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452215840 298 ASTMIWLTIILLVISGFFFPCIQGGIQTLIVRNTEGAFIGRVSGAIMPVFMGMMVIGMFISGYLKNTVSLVAVYVMSGVL 377
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160
|
....*....
gi 1452215840 378 IIIGASFLF 386
Cdd:pfam07690 161 SLLAAVLLL 169
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
37-386 |
2.71e-04 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 42.57 E-value: 2.71e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452215840 37 NNNPVYVSLISVAEFAPIFLFGLIGGTFADRWRPKRTMVWSdlLSALSVGAVLLALMNGGWiALLIGTFISASLSQFSQP 116
Cdd:cd17330 30 GASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLS--LAGSAVSYVLLGLSRNLW-LLFLARFLDGLTGGNVSV 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452215840 117 SAMKLYKRHVQVEQLQGvMAMSQTLVAVFMVLGPVIGTFIFIQFGINASLILTVVLFLGSSLVLATLPRdaeepksgdag 196
Cdd:cd17330 107 AQAYIADITDEEERAKA-FGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAAALALLNLVLVLFFLP----------- 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452215840 197 gfikelkaglryigsnqSLRTLCLTFSAVGLASGLTQPLQIFLVIENLGQDKQFLQWLVMTNG-AAMLAGGAVMIGISKK 275
Cdd:cd17330 175 -----------------PLRRLLLVYFLIALAFAGLESVFSLFLKDRFGFSPSQIGLLLALVGiAGILAQLLLIPRLAKR 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452215840 276 VKPQLLLMLGLLVTAVCTIGIGASTMIWLTIILLVISGFFFPCIQGGIQTLIVRNTEGAFIGRVSGAIMPVFMGMMVIGM 355
Cdd:cd17330 238 LGERKLLRLGLLLAIIGLLLLPFASSVPLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQGIIQSLQSLARIIGP 317
|
330 340 350
....*....|....*....|....*....|.
gi 1452215840 356 FISGYLKNTVSLVAVYVMSGVLIIIGASFLF 386
Cdd:cd17330 318 LLAGPLYSFLGPGVPFLLAAGLLLIALFLLS 348
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
39-388 |
2.84e-04 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 42.56 E-value: 2.84e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452215840 39 NPVYVSLISVAEFAPIFLFGLIGGTFADRWRPKRTMVWSDLLSALsvgAVLLALMNGGWIALLIGTFI----SASLSQFS 114
Cdd:cd17474 32 SPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGI---GGLLCGLSDSFALLLAGRALqgigAAGLGPLA 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452215840 115 QPSAMKLYKRHVQVEqlqgVMAMSQTLVAVFMVLGPVIGTFIfIQFGINASLILTVVLFLGSSLVLATLPRDAEEPKSGD 194
Cdd:cd17474 109 LTLIGDLFEGGERAK----AMGLYEAALGLGIAVGPLLGGLL-AAISWRYPFFLLAALIPVAFLAILFLLPEPKEKAKSS 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452215840 195 AGGFIKELKAGLRYIGSNQSLRTLCLTFSAVGlasgltqPLQIFL--VIENLGQDKQFLQWLVMTNGAAMLAGGAVMIG- 271
Cdd:cd17474 184 SATKLRDLKKALRGRGLLTFLVSAFLYFFLYF-------AFLTYLpfLLELLYGISPIIIGLLFAGWSVLLALGSLFVGr 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452215840 272 -ISKKVKPQLLLMLGLLVTAVCTIGIGASTMIWLTIILLVISGFFFPCIQGGIQTLIVRNTEGAFIGRVSGAIMPVFMGM 350
Cdd:cd17474 257 lLKKRFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLG 336
|
330 340 350
....*....|....*....|....*....|....*...
gi 1452215840 351 MVIGMFISGYLKNTVSLVAVYVMSGVLIIIGASFLFPL 388
Cdd:cd17474 337 QAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVLLALL 374
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
59-385 |
7.27e-04 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 41.41 E-value: 7.27e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452215840 59 LIGGTFADRWRPKRTMVWSdlLSALSVGAVLLALMNGGWIaLLIGTFISA----SLSQFSQPSAMKLYkrhvQVEQLQGV 134
Cdd:cd17320 52 LLYGPLSDRFGRRPVLLAG--LLLFILASLLCALASSIEQ-LLIARFLQGlgaaAGSVVARAIVRDLY----SGAELAKI 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452215840 135 MAMSQTLVAVFMVLGPVIGTFIFIQFGINAS----LILTVVLFLGSSLVLA-TLPRDAEEPKSGDAGGFIKELKAGLRYI 209
Cdd:cd17320 125 FSLLMMILAIAPALAPLLGGLLLLFFGWRAIfvflALLGLLLLLLVLLFLPeTLPEEKRKPLLSSLLRAYKRVLKNRRFL 204
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452215840 210 GsnqslRTLCLTFSAVGLASGLTQ-PlqiFLVIENLGQDKQFLQWLVMTNGAAMLAGGAVMIGISKKVKPQLLLMLGLLV 288
Cdd:cd17320 205 G-----YALALGLSFAGLFAYLAAaP---FIYIEQLGLSPAQFGLLFALNAIALILGSLLNGRLVRRFGPRRLLRLGLLL 276
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452215840 289 TAVCTIGIGASTMIWLTIILLVISGFFFPCIQGGIQTLIVRNTEGAFIGRVSGAIMPVF----MGMMVIGMFISGYLKNT 364
Cdd:cd17320 277 LLAAALVLLLAALLGGLSLWPLVAPLFLIFFGFGLIFPNATSLALEPFPHVAGTASALLgflqFLIGALAGALVGLLPNG 356
|
330 340
....*....|....*....|...
gi 1452215840 365 --VSLVAVYVMSGVLIIIGASFL 385
Cdd:cd17320 357 taLPMGLLILVLGLLALLLLILL 379
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
218-386 |
7.70e-04 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 41.39 E-value: 7.70e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452215840 218 LCLTFSAVGLASGLTQPLqIFLVIENLGQDKQFLQWLVMTNGAAMLAGGAVMIGISKKVKPQLLLMLGLLVTAVCTIGIG 297
Cdd:cd17477 1 LLLSVALLGLGSGLLLPL-LSLRLEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452215840 298 ASTMIWLTIILLVISGFFFPCIQGGIQTLIVRNTEGAFIGRVSGAIMPVFMGMMVIGMFISGYLknTVSLVAVYVMSGVL 377
Cdd:cd17477 80 LTDSPWVWFLLRFVMGIGLAGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFALGPLLLALV--GTAGALPFLIAAVL 157
|
....*....
gi 1452215840 378 IIIGASFLF 386
Cdd:cd17477 158 LLLALVPLL 166
|
|
| PRK08633 |
PRK08633 |
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated |
39-228 |
9.30e-04 |
|
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated
Pssm-ID: 236315 [Multi-domain] Cd Length: 1146 Bit Score: 41.45 E-value: 9.30e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452215840 39 NPVYVSLISVAEFAPIFLFGLIGGTFADRWRPKRTMVWSDLLSALSVGAVLLALMNGGWIALLIGTFISASLSQFSQPSA 118
Cdd:PRK08633 45 QVILTAIVNALFLLPFLLLSSPAGFLADKFSKNRVIRIVKLFEVGLTLLIVLAYYLGWFWLAFAVTFLLGAQSAIYSPAK 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452215840 119 MKLYKRHVQVEQL---QGVMAMSqTLVAVfmVLGPVIGTFIF-IQFGINASLILTVVLFLGSSLVLA---------TLPR 185
Cdd:PRK08633 125 YGIIPELVGKENLsraNGLLEAF-TIVAI--LAGTALFSFLFeSVNGNTPSEILGRIAPAGLVLLAVavlglifayRLPK 201
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 1452215840 186 -DAEEPKSGDAGGFIK--ELKAGLRYIGSNQSLRtlcltFSAVGLA 228
Cdd:PRK08633 202 vPAAAPEVFDKKKYLFpkLLWRNLKLLRSDRVLW-----LAIIGLS 242
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
1-148 |
3.57e-03 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 39.19 E-value: 3.57e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452215840 1 MFSNRYVRTIILSRVLLQFGIWIRNYAVLLFVSELTNNNPVYVSLISVAEFAPIFLFGLIGGTFADRWRPKRTMVWSDLL 80
Cdd:COG2814 203 LLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLL 282
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1452215840 81 SALSVGAVLLAlmnGGWIALLIGTFISASLSQFSQPSAMKLYKRHVQVEQLQGVMAMSQTLVAVFMVL 148
Cdd:COG2814 283 LALGLLLLALA---GSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPL 347
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
5-174 |
4.99e-03 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 38.71 E-value: 4.99e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452215840 5 RYVRTIILSRVLLQFGIWIRNYAVLLFVSELTNNNPVYVS-LISVAEFAPIFLFGLIGGTFADRWRPKRTMVWSDLLSAL 83
Cdd:cd17330 174 PPLRRLLLVYFLIALAFAGLESVFSLFLKDRFGFSPSQIGlLLALVGIAGILAQLLLIPRLAKRLGERKLLRLGLLLAII 253
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452215840 84 svGAVLLALMNGGWIaLLIGTFISASLSQFSQPSAMKLYKRHVQVEQLQGVMAMSQTLVAVFMVLGPVIGTFIFIQFGIN 163
Cdd:cd17330 254 --GLLLLPFASSVPL-LVLAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYSFLGPG 330
|
170
....*....|.
gi 1452215840 164 ASLILTVVLFL 174
Cdd:cd17330 331 VPFLLAAGLLL 341
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
39-273 |
5.04e-03 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 38.64 E-value: 5.04e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452215840 39 NPVYVSLISVAEFAPIFLFGLIGGTFADRWRPKRTMVWSDLLSALsvgAVLLALMNGGWIALLIGTFISASLSQFSQPSA 118
Cdd:COG0477 47 SSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGL---ASLLCGLAPSPELLIAARALQGIGAGGLMPGA 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452215840 119 MKLYKRHVQVEQLQGVMAMSQTLVAVFMVLGPVIGTFIFIQFGINASLILTVVLFLGSSLVLATLPRDAEEPKSGDAGGF 198
Cdd:COG0477 124 LALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLINAPLGLLALVLRLRLPESRGLLLALLALAL 203
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1452215840 199 IKELKAGLRYIGSNQSLRTLCLTFSAVGLASGLTQPLQIFLVIENLGQDKQFLQWLVMTNGAAMLAGGAVMIGIS 273
Cdd:COG0477 204 AALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALLLLLALLLLAALLLLLLLLLLLALLLAL 278
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
7-189 |
6.50e-03 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 38.31 E-value: 6.50e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452215840 7 VRTIILSRVLLQFGIWIRNYAVLLFVSELTNNNPVYVSLISVAEFAPIFLFGLIGGTFADRWRPKRTMVWSdLLSALSVG 86
Cdd:COG2271 182 FWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLA-IGLLLAAL 260
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452215840 87 AVLLALMNGGWIALLIGTFISASLSQFSQPSAMKLYKRHVQVEQLQGVMAMSQTLVAVFMVLGPVIGTFIFIQFGINASL 166
Cdd:COG2271 261 ALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAF 340
|
170 180
....*....|....*....|...
gi 1452215840 167 ILTVVLFLGSSLVLATLPRDAEE 189
Cdd:COG2271 341 LLLAALALLAALLALLLLRETRK 363
|
|
| |
